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Introduction: The digitalized PREVED (PREgnancy, PreVention, Endocrine Disruptor) questionnaire was used in the clinical practices of health professionals (HP) who adhered to the MEDPREVED strategy. The objectives were to assess the strategy and to determine if it could improve access to endocrine disruptor (ED) exposure prevention. Methods: After having filled in the digital questionnaire in HP waiting rooms, patients were invited to talk about ED exposure during the consultation. HPs were previously trained in ED and had received a prevention kit for their patients. After the seven-month implementation phase, the evaluation phase consisted of five mixed assessments: interviews with: (i) patients who were young children’s parents; (ii) patients in the general population; (iii) paediatricians; (iv) midwives; and a quantitative study on GPs. Assessment concerned feasibility, accessibility, and usefulness of the strategy; we then used the Levesque model to evaluate how it could improve access to ED exposure prevention. Results: The study included 69 participants. The strategy appeared feasible for the filling-out step due to digital and environment access. However, it depended on patient and HP profiles. The strategy seemed useful insofar as it facilitated reflexive investment, an intention to healthy behaviour and, rather rarely, talk about ED exposure. The beginning of this discussion depended on time, prioritizing of the topic and HP profile. The strategy has confirmed the Levesque model’s limiting factors and levers to access ED prevention. Conclusions: The MEDPREVED strategy is feasible, accessible, and useful in clinical prevention practice. Further study is needed to measure the impact on knowledge, risk perception and behavior of beneficiaries of the MEDPREVED strategy in the medium and long term.

It was more than 45 years ago that Gunnar Johansson invented the point-light display technique. This showed for the first time that kinematics is crucial for action recognition, and that humans are very sensitive to their conspecifics' movements. As a result, many of today's researchers use point-light displays to better understand the mechanisms behind this recognition ability. In this paper, we propose PLAViMoP, a new database of 3D point-light displays representing everyday human actions (global and fine-motor control movements), sports movements, facial expressions, interactions, and robotic movements. Access to the database is free, at https://plavimop.prd.fr/en/motions . Moreover, it incorporates a search engine to facilitate action retrieval. In this paper, we describe the construction, functioning, and assessment of the PLAViMoP database. Each sequence was analyzed according to four parameters: type of movement, movement label, sex of the actor, and age of the actor. We provide both the mean scores for each assessment of each point-light display, and the comparisons between the different categories of sequences. Our results are discussed in the light of the literature and the suitability of our stimuli for research and applications.

Episodic memory decline with aging may be due to an age-related deficit in encoding processing, older adults having increasing difficulty to self-initiate encoding strategies that support later retrieval. Using event-related potentials (ERPs), the present study explored for the first time the neural correlates of successful encoding in a resource-dependent episodic memory task, in which participants had to self-initiate processes at both encoding and retrieval. At the behavioral level, results confirm the better memory performance of young than older adults. Comparing the neural activity elicited by studied items that were and were not subsequently recalled (Subsequent Memory Effect, SME), electrophysiological data revealed that younger adults showed a significant and sustained SME, shifting from parietal to frontal areas, suggesting that they self-initiated deep encoding strategies. In older adults, the duration of brain activity was shorter and located more in the parietal than frontal areas, suggesting that they used shallow rather than deep processes. Consistent with the hypothesis of a deficit in self-initiated strategies in aging, our findings suggest that when older adults are faced with a difficult memory task (no encoding support and no cue at retrieval), they engage fewer elaborative strategies than young adults, resulting in impaired episodic memory performance.

The objective of this study was to examine age-related effects on behavioral performance and metabolic activity of the prefrontal cortex (PFC) in a dual-task paradigm involving fine-motor control and executive-function control. Thirty-one adults (20 ± 1.1 years) and 33 older adults (70.7 ± 5.1 years) performed, separately and then concurrently, a modified Fitts task on targets of different sizes (Index of Difficulty: ID = 3; 4; 5 bits) and the random number generation task (RNG). Movement time (MT) and count score (CS) were the dependent variables for the modified Fitts task and the RNG task, respectively. Relative changes in concentrations of oxyhemoglobin [HbO2] and deoxyhemoglobin [HHb] were recorded continuously on the left and right PFCs, with near-infrared spectroscopy (Oxymon MkIII-Artinis) with an acquisition rate of 10 Hz. Our results showed large motor dual-task cost in seniors compared to young adults. Regarding hemodynamic activity, we have observed a prominent activation of the PFC in the young adults compared to the seniors during the dual-task condition.

The serial analysis of gene expression (SAGE) is a powerful method to compare gene expression of mRNA populations. To provide quantitative expression levels on a genome-wide scale, the Cancer Genome Anatomy Project (CGAP) uses SAGE. Over 7 million SAGE tags, from 171 human cell types have been assembled. The growing number of laboratories involved in SAGE research necessitates the use of software that provides statistical analysis of raw data, allowing the rapid visualization and interpretation of results. We have created the first simple tool that performs statistical analysis on SAGE data, identifies the tags differentially expressed and shows the results in a scatter plot. It is freely available and accessible at http://bioserv.rpbs.jussieu.fr/websage/index.php.