1,739 results on '"Jassem A"'
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2. X-ray diffraction analysis for main peaks and the noises of single and multi-walled carbon nanotubes
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null Eman J. Theyab, null Muhammed N. Muhammed, null Firas H. Abdulrazzak, null Aseel M. Ajobree, null Zena M. Jassem, null Israa M. Radhi, null Samira Mammadova, null Kalid T. Abdullah, null Kalida Ali, null Ahmed A. Ismail, null Tariq H. Al Mgheer, null Ahmed M. Abass, null Ayad F. Alkaim, null Takialdin A. Himdan, and null Falah H. Hussein
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The XRD for carbon nanotubes shows the main two peaks at 2Ө ≈ 25∘ and 43∘ with many noises for all the line from 5∘ to 80∘ which depend on nature of structure. The noises produce from instrumental sources and the physical properties of tubular structure and that represent by inter and intra Van Der Waals forces. Most of the noises were removed by using computerized programs while it is referred to nature of tubular structure with one or many sheets of graphene. The most of this noises represent the nature of structure which reduces with increase graphene sheets, thus removing it delete the specific proprieties of CNTs. The graphite behave the same properties of tubular structure which variant with number of sheets.
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- 2023
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3. The Hidden Side of Learning English as a Socially Motivated Behavior in Iran Educational System
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Jassem Fathabadi
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Arts and Humanities (miscellaneous) ,General Social Sciences ,Law ,Social Sciences (miscellaneous) ,Education - Published
- 2023
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4. Increasing digital capabilities of agricultural projects to reduce costs
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Nasser Jassem Nasser Al-Ssadi, Heyder G Wannes Alkarawy, and Jassim Mohammad Hussein
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Human Factors and Ergonomics ,Development - Abstract
This paper provides an overview of the extent of digital transformation in the Republic of Iraq. It contains a discussion of the opportunities and challenges that the economy faces due to digitization and its potential to promote a sustainable economic transformation to achieve the 2030 Agenda for Sustainable Development. By analyzing the experience of implementing these projects, it is possible to identify the economic and accounting actions that can be taken to reduce the costs of digitizing crop production enterprises, as well as identify problems in industrial relations that impede effective digitization and the establishment of a geographic information system for regional agriculture in the Middle Euphrates, Iraq. Based on an assessment of the state of digitization in the Middle Euphrates region of Iraq, key areas for digitization efforts in the agricultural sector were identified. The study revealed the fundamental trends of modern and innovative digital technologies presented by the “Digital Agriculture” management project with special data processing methods and the use of geographic information systems that make it possible to obtain a significant economic impact to reduce and rationalize costs. According to the results obtained, the use of elements of digital technologies in crop production in the Middle Euphrates, Iraq, has a significant economic effect, the replication of which can greatly accelerate the development of the industry. These efforts to unlock Iraq's digital potential will accelerate the achievement of the Sustainable Development Goals.
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- 2023
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5. Efficacy and safety of first-line lorlatinib versus crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer: updated analysis of data from the phase 3, randomised, open-label CROWN study
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Benjamin J, Solomon, Todd M, Bauer, Tony S K, Mok, Geoffrey, Liu, Julien, Mazieres, Filippo, de Marinis, Yasushi, Goto, Dong-Wan, Kim, Yi-Long, Wu, Jacek, Jassem, Froylán López, López, Ross A, Soo, Alice T, Shaw, Anna, Polli, Rossella, Messina, Laura, Iadeluca, Francesca, Toffalorio, and Enriqueta, Felip
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Pulmonary and Respiratory Medicine - Abstract
After a median follow-up of 18·3 months, the third-generation anaplastic lymphoma kinase (ALK) tyrosine-kinase inhibitor, lorlatinib, improved progression-free survival in patients with treatment-naive, ALK-positive non-small-cell lung cancer in the phase 3 CROWN study. Here we report updated efficacy data, including intracranial activity, from an unplanned analysis after 3 years of follow-up.CROWN is an ongoing, international, randomised, open-label phase 3 trial done in 104 centres in 23 countries worldwide. Eligible participants were aged 18 years and older or aged 20 years and older (depending on local regulations) with advanced, ALK-positive non-small-cell lung cancer, had received no previous systemic treatment for metastatic disease, had at least one extracranial measurable target lesion (according to the Response Evaluation Criteria in Solid Tumours [RECIST], version 1.1), and had an Eastern Cooperative Oncology Group performance status score of 0-2. Patients were randomly assigned (1:1) to oral lorlatinib 100 mg daily or oral crizotinib 250 mg twice daily in 28-day cycles. Randomisation was stratified by the presence or absence of brain metastasis, and by ethnicity. Since the primary endpoint of the study had been met at the planned interim analysis, no further formal analysis of progression-free survival was planned, per protocol. The current unplanned analysis was done to further characterise tumour-related endpoints with a longer follow-up and is presented descriptively. For the planned study, the primary endpoint was progression-free survival assessed by blinded independent central review. Secondary endpoints included progression-free survival (investigator), objective response rate, intracranial objective response rate, time to intracranial progression, duration of response, intracranial duration of response, and safety. Efficacy endpoints were also assessed by the presence or absence of baseline brain metastases. This study is registered with ClinicalTrials.gov, NCT03052608.Between May 11, 2017, and Feb 28, 2019, 425 patients were screened for eligibility, of whom 296 were enrolled and randomly assigned to the lorlatinib (n=149) or crizotinib (n=147) group. At data cutoff for this unplanned analysis (Sept 20, 2021), median duration of follow-up for progression-free survival was 36·7 months (IQR 31·3-41·9) for lorlatinib and 29·3 months (10·8-35·0) for crizotinib. Median progression-free survival by blinded independent central review was not reached (95% CI not reached-not reached) for lorlatinib and was 9·3 months (7·6-11·1) for crizotinib (hazard ratio [HR] 0·27 [95% CI 0·18-0·39]). 3-year progression-free survival was 64% (95% CI 55-71) in the lorlatinib group and 19% (12-27) in the crizotinib group. Progression-free survival (investigator), objective response rate, intracranial objective response rate, time to intracranial progression, and duration of response were improved with lorlatinib versus crizotinib. In patients with baseline brain metastases (n=37 lorlatinib; n=39 crizotinib), the HR for time to intracranial progression for lorlatinib versus crizotinib was 0·10 (95% CI 0·04-0·27); in patients without baseline brain metastases (n=112 lorlatinib; n=108 crizotinib), the HR was 0·02 (95% CI 0·002-0·14). In patients without brain metastases, one (1%) in the lorlatinib group and 25 (23%) in the crizotinib group had intracranial progression. Grade 3-4 adverse events occurred in 113 (76%) of 149 patients (most commonly due to altered lipid levels) with lorlatinib and in 81 (57%) of 142 patients with crizotinib. Adverse events led to treatment discontinuation in 11 (7%) patients in the lorlatinib group and 14 (10%) patients in the crizotinib group. There were no new safety signals.These updated, long-term data from CROWN show the durable benefit of lorlatinib over crizotinib in patients with treatment-naive, ALK-positive non-small-cell lung cancer and support the use of first-line lorlatinib in patients with and without baseline brain metastases.Pfizer.
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- 2023
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6. Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study
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Bernardo Sousa-Pinto, Cristina Jácome, Ana Margarida Pereira, Frederico S Regateiro, Rute Almeida, Wienczyslawa Czarlewski, Marek Kulus, Mohamed H Shamji, Louis-Philippe Boulet, Matteo Bonini, Luisa Brussino, G Walter Canonica, Alvaro A Cruz, Bilun Gemicioglu, Tari Haahtela, Maciej Kupczyk, Violeta Kvedariene, Desirée Larenas-Linnemann, Renaud Louis, Marek Niedoszytko, Nhân Pham-Thi, Francesca Puggioni, Jan Romantowski, Joaquin Sastre, Nicola Scichilone, Luis Taborda-Barata, Maria Teresa Ventura, Rafael José Vieira, Ioana Agache, Anna Bedbrook, Karl C Bergmann, Rita Amaral, Luís Filipe Azevedo, Sinthia Bosnic-Anticevich, Guy Brusselle, Roland Buhl, Lorenzo Cecchi, Denis Charpin, Claudia Chaves Loureiro, Frédéric de Blay, Stefano Del Giacco, Philippe Devillier, Ewa Jassem, Guy Joos, Marek Jutel, Ludger Klimek, Piotr Kuna, Daniel Laune, Jorge Luna Pech, Mika Makela, Mario Morais-Almeida, Rachel Nadif, Hugo E Neffen, Ken Ohta, Nikolaos G Papadopoulos, Alberto Papi, Benoit Pétré, Oliver Pfaar, Daniela Rivero Yeverino, Carlos Robalo Cordeiro, Nicolas Roche, Ana Sá-Sousa, Boleslaw Samolinski, Aziz Sheikh, Charlotte Suppli Ulrik, Omar S Usmani, Arunas Valiulis, Olivier Vandenplas, Pedro Vieira-Marques, Arzu Yorgancioglu, Torsten Zuberbier, Josep M Anto, João A Fonseca, Jean Bousquet, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (MGD) Service de pneumologie
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Dyspnea ,electronic daily control score ,e-DASTHMA ,patient ,Health Information Management ,Surveys and Questionnaires ,Humans ,Reproducibility of Results ,Medicine (miscellaneous) ,Decision Sciences (miscellaneous) ,Health Informatics ,Asthma/diagnosis ,Rhinitis, Allergic/diagnosis - Abstract
BACKGROUND: Validated questionnaires are used to assess asthma control over the past 1-4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA).METHODS: We used MASK-air data (freely available to users in 27 countries) to develop and assess different daily control scores for asthma. Data-driven control scores were developed based on asthma symptoms reported by a visual analogue scale (VAS) and self-reported asthma medication use. We included the daily monitoring data from all MASK-air users aged 16-90 years (or older than 13 years to 90 years in countries with a lower age of digital consent) who had used the app in at least 3 different calendar months and had reported at least 1 day of asthma medication use. For each score, we assessed construct validity, test-retest reliability, responsiveness, and accuracy. We used VASs on dyspnoea and work disturbance, EQ-5D-VAS, Control of Allergic Rhinitis and Asthma Test (CARAT), CARAT asthma, and Work Productivity and Activity Impairment: Allergy Specific (WPAI:AS) questionnaires as comparators. We performed an internal validation using MASK-air data from Jan 1 to Oct 12, 2022, and an external validation using a cohort of patients with physician-diagnosed asthma (the INSPIRERS cohort) who had had their diagnosis and control (Global Initiative for Asthma [GINA] classification) of asthma ascertained by a physician.FINDINGS: We studied 135 635 days of MASK-air data from 1662 users from May 21, 2015, to Dec 31, 2021. The scores were strongly correlated with VAS dyspnoea (Spearman correlation coefficient range 0·68-0·82) and moderately correlated with work comparators and quality-of-life-related comparators (for WPAI:AS work, we observed Spearman correlation coefficients of 0·59-0·68). They also displayed high test-retest reliability (intraclass correlation coefficients range 0·79-0·95) and moderate-to-high responsiveness (correlation coefficient range 0·69-0·79; effect size measures range 0·57-0·99 in the comparison with VAS dyspnoea). The best-performing score displayed a strong correlation with the effect of asthma on work and school activities in the INSPIRERS cohort (Spearman correlation coefficients 0·70; 95% CI 0·61-0·78) and good accuracy for the identification of patients with uncontrolled or partly controlled asthma according to GINA (area under the receiver operating curve 0·73; 95% CI 0·68-0·78).INTERPRETATION: e-DASTHMA is a good tool for the daily assessment of asthma control. This tool can be used as an endpoint in clinical trials as well as in clinical practice to assess fluctuations in asthma control and guide treatment optimisation.FUNDING: None.
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- 2023
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7. Synthesis of nanomaterials: Controlling of experimental Conditions
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null Aseel M. Ajobree, null Zena M. Jassem, null Israa M. Radhi, null Samira A. Mammadova, null Kalid T. Abdullah, null Ahmed H. Al-Shami, null Ahmed A. Ismail, null Tariq H Al Mgheer, null Ahmed M. Abass, null Firas H. Abdulrazzak, null Ayad F. Alkaim, null Takialdin A. Himdan, and null Falah H. Hussein
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Numerous studies reported ‘’ how nanomaterials (NMs) can be prepared’.’ However, in this work, we are trying to explain some ideas about ‘’the best route and mechanism for synthesizing ideal size and shape for maximum benefit of applications’’. The strategy of synthesizing of nanomaterials with different dimensions by highlighting on the supposed mechanism that could be helps to select the best conditions for the preparations of nanomaterials will be explained. The content also deals with perfect conditions for maximum ideal structure to the great physio-chemical properties and minimum disadvantage which may reduce the activity. Keeping in mind the experimental behavior that could be enhance the activity of synthesis different types of nanomaterials.
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- 2023
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8. Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer
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Imran Khan, Brunilde Gril, Anurag N. Paranjape, Christina M. Robinson, Simone Difilippantonio, Wojciech Biernat, Michał Bieńkowski, Rafał Pęksa, Renata Duchnowska, Jacek Jassem, Priscilla K. Brastianos, Philippe Metellus, Emilie Bialecki, Carolyn C. Woodroofe, Haitao Wu, Rolf E. Swenson, and Patricia S. Steeg
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Cancer Research ,Oncology - Abstract
Advances in drug treatments for brain metastases of breast cancer have improved progression-free survival but new, more efficacious strategies are needed. Most chemotherapeutic drugs infiltrate brain metastases by moving between brain capillary endothelial cells, paracellular distribution, resulting in heterogeneous distribution, lower than that of systemic metastases. Herein, we tested three well-known transcytotic pathways through brain capillary endothelial cells as potential avenues for drug access: transferrin receptor (TfR) peptide, low-density lipoprotein receptor 1 (LRP1) peptide, albumin. Each was far-red labeled, injected into two hematogenous models of brain metastases, circulated for two different times, and their uptake quantified in metastases and uninvolved (nonmetastatic) brain. Surprisingly, all three pathways demonstrated distinct distribution patterns in vivo. Two were suboptimal: TfR distributed to uninvolved brain but poorly in metastases, while LRP1 was poorly distributed. Albumin distributed to virtually all metastases in both model systems, significantly greater than in uninvolved brain (P < 0.0001). Further experiments revealed that albumin entered both macrometastases and micrometastases, the targets of treatment and prevention translational strategies. Albumin uptake into brain metastases was not correlated with the uptake of a paracellular probe (biocytin). We identified a novel mechanism of albumin endocytosis through the endothelia of brain metastases consistent with clathrin-independent endocytosis (CIE), involving the neonatal Fc receptor, galectin-3, and glycosphingolipids. Components of the CIE process were found on metastatic endothelial cells in human craniotomies. The data suggest a reconsideration of albumin as a translational mechanism for improved drug delivery to brain metastases and possibly other central nervous system (CNS) cancers. In conclusion, drug therapy for brain metastasis needs improvement. We surveyed three transcytotic pathways as potential delivery systems in brain-tropic models and found that albumin has optimal properties. Albumin used a novel endocytic mechanism.
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- 2023
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9. Current and future applications of liquid biopsy in non-small-cell lung cancer—a narrative review
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Bartłomiej Tomasik, Marcin Skrzypski, Michał Bieńkowski, Rafał Dziadziuszko, and Jacek Jassem
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Oncology - Published
- 2023
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10. Outcomes after liver transplantation using deceased after circulatory death donors: A comparison of outcomes in the UK and the US
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Tommy Ivanics, Marco P. A. W. Claasen, Madhukar S. Patel, Emmanouil Giorgakis, Shirin E. Khorsandi, Parthi Srinivasan, Andreas Prachalias, Krishna Menon, Wayel Jassem, Miriam Cortes, Blayne A. Sayed, Amit K. Mathur, Kate Walker, Rhiannon Taylor, Nigel Heaton, Neil Mehta, Dorry L. Segev, Allan B. Massie, Jan H. P. van der Meulen, Gonzalo Sapisochin, and David Wallace
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SDG 3 - Good Health and Well-being ,Hepatology - Abstract
Background and Aims: Identifying international differences in utilization and outcomes of liver transplantation (LT) after donation after circulatory death (DCD) donation provides a unique opportunity for benchmarking and population-level insight. Methods: Adult (≥18 years) LT data between 2008 and 2018 from the UK and US were used to assess mortality and graft failure after DCD LT. We used time-dependent Cox-regression methods to estimate hazard ratios (HR) for risk-adjusted short-term (0–90 days) and longer-term (90 days–5 years) outcomes. Results: One-thousand five-hundred-and-sixty LT receipts from the UK and 3426 from the US were included. Over the study period, the use of DCD livers increased from 15.7% to 23.9% in the UK compared to 5.1% to 7.6% in the US. In the UK, DCD donors were older (UK:51 vs. US:33 years) with longer cold ischaemia time (UK: 437 vs. US: 333 min). Recipients in the US had higher Model for End-stage Liver Disease (MELD) scores, higher body mass index, higher proportions of ascites, encephalopathy, diabetes and previous abdominal surgeries. No difference in the risk-adjusted short-term mortality or graft failure was observed between the countries. In the longer-term (90 days–5 years), the UK had lower mortality and graft failure (adj.mortality HR:UK: 0.63 (95% CI: 0.49–0.80); graft failure HR: UK: 0.72, 95% CI: 0.58–0.91). The cumulative incidence of retransplantation was higher in the UK (5 years: UK: 11.9% vs. 4.6%; p
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- 2023
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11. First-Line Nivolumab Plus Ipilimumab With Chemotherapy Versus Chemotherapy Alone for Metastatic NSCLC in CheckMate 9LA: 3-Year Clinical Update and Outcomes in Patients With Brain Metastases or Select Somatic Mutations
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Luis G. Paz-Ares, Tudor-Eliade Ciuleanu, Manuel Cobo, Jaafar Bennouna, Michael Schenker, Ying Cheng, Oscar Juan-Vidal, Hideaki Mizutani, Alejo Lingua, Felipe Reyes-Cosmelli, Niels Reinmuth, Juliana Menezes, Jacek Jassem, Svetlana Protsenko, Eduardo Richardet, Enriqueta Felip, Kynan Feeney, Bogdan Zurawski, Aurelia Alexandru, Emmanuel de la Mora Jimenez, Shaker Dakhil, Shun Lu, Martin Reck, Thomas John, Nan Hu, Xiaoqing Zhang, Judi Sylvester, Laura J. Eccles, Diederik J. Grootendorst, David Balli, Jaclyn Neely, David P. Carbone, Institut Català de la Salut, [Paz-Ares LG] Medical Oncology Department, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain. [Ciuleanu TE] Department of Medical Oncology, Institutul Oncologic Prof Dr Ion Chiricuta and University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania. [Cobo M] Department of Medical Oncology, Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, IBIMA, Málaga, Spain. [Bennouna J] Department of Pneumology, Thoracic Oncology, University Hospital of Nantes and INSERM, CRCINA, Nantes, France. [Schenker M] Department of Medical Oncology, SF Nectarie Oncology Center, Craiova, Romania. [Cheng Y] Department of Oncology, Jilin Cancer Hospital, Changchun, Jilin, People’s Republic of China. [Felip E] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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Pulmonary and Respiratory Medicine ,Otros calificadores::/uso terapéutico [Otros calificadores] ,terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] ,diagnóstico::pronóstico::resultado del tratamiento [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms::Bronchial Neoplasms::Carcinoma, Bronchogenic::Carcinoma, Non-Small-Cell Lung [DISEASES] ,neoplasias::neoplasias por localización::neoplasias torácicas::neoplasias del tracto respiratorio::neoplasias pulmonares::neoplasias de los bronquios::carcinoma broncogénico::carcinoma de pulmón de células no pequeñas [ENFERMEDADES] ,Other subheadings::Other subheadings::/drug therapy [Other subheadings] ,Diagnosis::Prognosis::Treatment Outcome [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Quimioteràpia combinada ,Oncology ,Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Avaluació de resultats (Assistència sanitària) ,Other subheadings::/therapeutic use [Other subheadings] ,Pulmons - Càncer - Tractament - Abstract
Non–small cell lung cancer; Brain metastases; Somatic mutations Càncer de pulmó de cèl·lules no petites; Metàstasis cerebrals; Mutacions somàtiques Cáncer de pulmón de células no pequeñas; Metástasis cerebrales; Mutaciones somáticas Introduction In the phase 3 CheckMate 9LA study, nivolumab plus ipilimumab with chemotherapy prolonged overall survival (OS) versus chemotherapy alone. We report updated efficacy and safety (≥3 y of follow-up), clinical outcomes in patients with baseline brain metastases, and exploratory somatic mutation analyses. Methods Adults with stage IV or recurrent NSCLC, no known sensitizing EGFR or ALK alterations, and Eastern Cooperative Oncology Group performance status less than or equal to 1 were randomized 1:1 to nivolumab 360 mg every 3 weeks plus ipilimumab 1 mg/kg every 6 weeks with chemotherapy (two cycles) or chemotherapy alone (four cycles). Assessments included OS, progression-free survival (PFS), and objective response rate. Exploratory analyses included systemic and intracranial efficacy in patients with or without baseline brain metastases, in addition to OS and PFS by KRAS, TP53, STK11, and KEAP1 somatic mutation status in patients with nonsquamous NSCLC. Results With a minimum follow-up of 36.1 months, nivolumab plus ipilimumab with chemotherapy continued to prolong OS versus chemotherapy alone in the intent-to-treat population (median [hazard ratio; 95% confidence interval] OS: 15.8 versus 11.0 mo [0.74; 0.62–0.87]; 3-y OS: 27% versus 19%). Efficacy outcomes were improved in patients with pretreated baseline brain metastases (median [hazard ratio; 95% confidence interval] OS: 19.3 versus 6.8 mo [0.45; 0.29–0.70]; systemic PFS: 9.7 versus 4.1 mo [0.44; 0.28–0.69]; intracranial PFS: 11.4 versus 4.6 mo [0.42; 0.26–0.68]). A trend of OS benefit was observed in patients treated with nivolumab plus ipilimumab with chemotherapy versus chemotherapy alone, despite KRAS, TP53, and STK11 tumor mutations. Extended follow-up revealed no new safety signals. Conclusions With a 3-year minimum follow-up, nivolumab plus ipilimumab with two cycles of chemotherapy continued to have long-term, durable efficacy versus chemotherapy alone; a manageable safety profile; and survival benefit in patients with or without baseline brain metastases or select somatic mutations, further supporting the regimen as first-line treatment for patients with metastatic NSCLC. This study was supported by Bristol Myers Squibb (Princeton, NJ).
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- 2023
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12. الابعاد السياسية والاقتصادية الفاعلة على تفاقم مشكلات مطاحن الحبوب في محافظة كركوك
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Nassif Jassem Aswad Al- Ahbab and Yasser Hamad Khalaf Abdul- Jubouri
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تعد مشكلات الصناعة في العراق بشكل عام من المشاكل التي ترمي بضلالها على الواقع الاقتصادي و السياسي . حيث ان لكل مشكلة صناعية هناك ابعاد ودوافع ادت الى بروز تلك المشكلة ,قد تكون مفتعلة أو نتيجة لمجريات احداث اخرى تؤثر على واقع الصناعة بشكل عام, لاسيما ان المشاكل الصناعية في محافظة كركوك هي امتداد للمشاكل الصناعية المؤثرة في جميع أنحاء العراق , وتعد الابعاد السياسية والاقتصادية من أولى الابعاد تأثيرا على منشآت طحن الحبوب في محافظة كركوك, والتي تؤثر على سير عمل تلك المطاحن وعلى عملية تزويد البطاقة التموينية بالمنتوج , والذي بدوره يصل الى المواطنين ,حيث تحافظ على توازن أسعار السوق , ونقصها يؤدي الى ارتفاع الاسعار والذي من شأنه أن يؤثر على قوت المواطنين , حيث يدفع بالأمور الى منحنيات أخرى , وتفتح الباب للتجاذبات السياسية في هذا الشأن , لاسيما ان العديد من الاحزاب تنتفع من أي خلل يحصل للتدخل لتوسيع القاعدة الجماهيرية والتدخل في الامور الاقتصادية وذلك للترابط الوثيق بينهما, واستقرار هذين البعدين الاقتصادي والسياسي يعني استقرار الصناعة بشكل عام.
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- 2023
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13. Mechanical Small Bowel Obstruction Incidence, Causes, Signs, and Symptoms in Al – Yarmouk Teaching Hospital
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Maktoum Kawan Jassem and Hadeel Waleed Abdulrahman
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Objectives: To assess causes, signs & symptoms of mechanical obstruction of the small bowel. Background: Mechanical obstruction of the small bowel is a common clinical and surgical condition, often presenting with signs and symptoms like those seen in other acute abdominal disorders controversy remains as to which patients with small bowel obstruction need immediate surgical intervention and which may be managed conservatively. Patients and Methods: A prospective study to assess incidence, causes, signs, and symptoms among ninety-two patients undergoing surgeries due to mechanical small bowel obstruction in Al-Yarmouk Teaching Hospital. In a period between October 2016 and October 2017 patients have divided into two groups 1 patients had surgery during the first 24hr from the start of signs & symptoms and a group of 2 patients had surgery after 24hr since the beginning of signs & symptoms. Results: Among ninety-two patients included in this study the result was 54 male (58.7%) and 38 female (41.3%). Patients with the previous scar were 62 cases (67.4%). The most common causes of MOSB were adhesions (63%), obstructed hernia (29.3%) most common type was inguinal hernia (16.3%), tumors (4.34%) and other causes were Crohn’s, bezoar, and intussuscept. Conclusion: Mechanical obstruction. The small bowel is a severe condition and moderately common in cases of acute abdomen adhesions were the commonest cause of MOSB also a high incidence of strangulation was seen in obstructed hernia, and patients generally present with abdominal pain, nausea and emesis, abdominal distension, and progressive obstipation, the clinical finding of high fever. Localized or generalized severe abdominal tenderness, rebound tenderness, severe leukocytosis, or metabolic changes suggest possible complications of bowel necrosis, perforation, or generalized peritonitis. MSBO is usually suggested by plain abdominal radiographs and confirmed by a CT scan.
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- 2023
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14. European Groundshot—addressing Europe's cancer research challenges: a Lancet Oncology Commission
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Mark Lawler, Lynne Davies, Simon Oberst, Kathy Oliver, Alexander Eggermont, Anna Schmutz, Carlo La Vecchia, Claudia Allemani, Yolande Lievens, Peter Naredi, Tanja Cufer, Ajay Aggarwal, Matti Aapro, Kathi Apostolidis, Anne-Marie Baird, Fatima Cardoso, Andreas Charalambous, Michel P Coleman, Alberto Costa, Mirjam Crul, Csaba L Dégi, Federica Di Nicolantonio, Sema Erdem, Marius Geanta, Jan Geissler, Jacek Jassem, Beata Jagielska, Bengt Jonsson, Daniel Kelly, Olaf Kelm, Teodora Kolarova, Tezer Kutluk, Grant Lewison, Françoise Meunier, Jana Pelouchova, Thierry Philip, Richard Price, Beate Rau, Isabel T Rubio, Peter Selby, Maja Južnič Sotlar, Gilliosa Spurrier-Bernard, Jolanda C van Hoeve, Eduard Vrdoljak, Willien Westerhuis, Urszula Wojciechowska, and Richard Sullivan
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Settore MED/06 - Oncologia Medica ,Settore MED/42 - Igiene Generale e Applicata ,COVID-19 ,cancer ,oncology ,Europe ,European oncology commission ,Settore MED/01 - Statistica Medica ,Oncology ,The Lancet Oncology Commission ,Review and Opinion ,Neoplasms ,MEDICAL AND HEALTH SCIENCES ,Humans ,Health Services Research ,Europe, Eastern ,Pandemics - Abstract
Cancer research is a crucial pillar for countries to deliver more affordable, higher quality, and more equitable cancer care. Patients treated in research-active hospitals have better outcomes than patients who are not treated in these settings. However, cancer in Europe is at a crossroads. Cancer was already a leading cause of premature death before the COVID-19 pandemic, and the disastrous effects of the pandemic on early diagnosis and treatment will probably set back cancer outcomes in Europe by almost a decade. Recognising the pivotal importance of research not just to mitigate the pandemic today, but to build better European cancer services and systems for patients tomorrow, the Lancet Oncology European Groundshot Commission on cancer research brings together a wide range of experts, together with detailed new data on cancer research activity across Europe during the past 12 years. We have deployed this knowledge to help inform Europe's Beating Cancer Plan and the EU Cancer Mission, and to set out an evidence-driven, patient-centred cancer research roadmap for Europe. The high-resolution cancer research data we have generated show current activities, captured through different metrics, including by region, disease burden, research domain, and effect on outcomes. We have also included granular data on research collaboration, gender of researchers, and research funding. The inclusion of granular data has facilitated the identification of areas that are perhaps overemphasised in current cancer research in Europe, while also highlighting domains that are underserved. Our detailed data emphasise the need for more information-driven and data-driven cancer research strategies and planning going forward. A particular focus must be on central and eastern Europe, because our findings emphasise the widening gap in cancer research activity, and capacity and outcomes, compared with the rest of Europe. Citizens and patients, no matter where they are, must benefit from advances in cancer research. This Commission also highlights that the narrow focus on discovery science and biopharmaceutical research in Europe needs to be widened to include such areas as prevention and early diagnosis; treatment modalities such as radiotherapy and surgery; and a larger concentration on developing a research and innovation strategy for the 20 million Europeans living beyond a cancer diagnosis. Our data highlight the important role of comprehensive cancer centres in driving the European cancer research agenda. Crucial to a functioning cancer research strategy and its translation into patient benefit is the need for a greater emphasis on health policy and systems research, including implementation science, so that the innovative technological outputs from cancer research have a clear pathway to delivery. This European cancer research Commission has identified 12 key recommendations within a call to action to reimagine cancer research and its implementation in Europe. We hope this call to action will help to achieve our ambitious 70:35 target: 70% average 10-year survival for all European cancer patients by 2035.
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- 2023
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15. Using Remote Sensing Coupled with Analytic Hierarchy Process Approach for Evaluating Water Harvesting in Baglia Site
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Zahraa R. Fakher, Sahar T. Al-Mulla, and Riaed S. Jassem
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General Computer Science ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology - Abstract
This research involves the application of spectral indices and GIS techniques coupled with the Analytic Hierarchy Process, to assess Baglia site, eastern Missan, as a water harvesting potential site. The AHP and pairwise comparison have been used through select four criteria including TWI, TRI, MNDWI, and NDSI, which were deemed as impact factors for this study. All these criteria have been weighted according to their significance in the water harvesting system. The findings of the AHP analysis method explained that the WH potential zones in Baglia site were divided into three zones, namely, high, medium, and low suitability. The findings demonstrate that Bglia site, where the highly appropriate zone is located in the deep valley area, is the ideal location for setting up water harvesting operations. The low suitability zone, in contrast, is located in a higher terrain when there is a steep slope area.
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- 2022
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16. الأشرطة التجارية في المدن , دراسة لشارع الزهور (الدركزلية ) في مدينة الموصل
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Nashwan Mahmoud Jassem Al-Zaidi and Faris Ahmed Mansour Al-Jubouri
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تتباين مؤسسات الاستعمال التجاري في مدينة الموصل من حيث سعتها او المواد التي تتاجر بها او عدد الزبائن الذين يتعاملون معها او التي تختص ببيع الجملة او بيع المفرد .اما ما يهتم به الدارسون في جغرافية المدن هو التوزيع المكاني للاستعمال التجاري وانماطه وان الدراسات التي تختص بالبنية التجارية للمدن تنقسم الى عدة اصناف منها مايتعلق بمؤسسات لبيع المفرد وكيفية توزيعها وموقعها في المدينة وكذلك مؤسسات البيع بالجملة وبعض الدراسات التي تختص بالمنطقة التجارية وتعد الاشرطة التجارية احد مكونات التركيب التجاري للمدن الحديثة , فقد تنوعت وتعددت اشكالها وانواعها داخل المدن ,ولا توجد مدينة مهما صغر حجمها إلاّ وتحتل الوظيفة التجارية حيزاً مكانياً , اذ نلاحظ بعض الحوانيت والمخازن تنتشر في القرى الكبرى وهنالك قرى او أماكن مركزية تعقد فيها أسواق اسبوعية (في يوم من أيام الاسبوع) وتختار أماكن تخلو من أي نشاط خلال أيام الاسبوع إلاّ في يوم واحد منه ذلك هو يوم السوق، وهكذا تقتصر جاذبيتها على الوظيفة التجارية، ومن أهم مايتميز به الاستعمال التجاري صغر المساحة التي يحتلها ولكنه لايقوم بخدمة سكان المدينة وحدهم بل يتعداه الى سكان المناطق الريفية المحيطة بالمدينة (اقليمها او ظهيرتها)، ويزداد حجم هذا الاستعمال ويتسع كلّما إزدادت علاقات المدينة التجارية وكبر حجمها حتى إن قلت العلاقات تصبح عالمية كما في الحال الموانئ التجارية وقد ظهرت في التركيب التجاري لمدينة الموصل منذ المدة التي شهدت تطورا اقتصاديا مابين الحربين بسبب نشاط التصدير اذ لم تستطع الفسح التجارية في السوق القديم ( الخانات ) على استيعاب المحلات الجديدة .وقد تم في هذا البحث دراسة الشريط التجاري لشارع الزهور (الدركزلية ) والبالغ عدد محلاته 117 محلاً تجارياً تضم استعمالات تجارية متنوعة الا ان الاستعمال الطاغي على الشريط هو تجارة وصيانة الاجهزة الكهربائية اذ بلغ عدد محلات تجارة وصيانة الاجهزة الكهربائية 88 محلاً من مجموع 117 محلاً في الشريط التجاري.
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- 2022
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17. Post-treatment follow-up in common solid malignancies: expert panel recommendations
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Jacek Jassem, Anna Kowalczyk, Aleksander Biesiada, Renata Duchnowska, Rafał Dziadziuszko, Agnieszka Mastalerz-Migas, Andrzej Kawecki, Maciej Krzakowski, Piotr Potemski, Piotr Rutkowski, and Piotr Wysocki
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Cancer Research ,Oncology - Published
- 2022
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18. Comparative Anatomical, Histological, and Histochemical Study of the Duodenum between Common Moorhen (Gallinula chloropus) and Domestic Fowl (Gallus domesticus)
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Eman Jassem, Adel Hussein, and Alaa Sawad
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General Medicine - Published
- 2022
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19. Evaluation of the efficiency of the spatial distribution of some services provided by the municipality of Ramadi city
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Abdulnaser Sabri Al Shaher and Ayat H. Jassem
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- 2022
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20. Post Hoc Analysis of Lorlatinib Intracranial Efficacy and Safety in Patients With ALK-Positive Advanced Non–Small-Cell Lung Cancer From the Phase III CROWN Study
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Benjamin J. Solomon, Todd M. Bauer, Sai-Hong Ignatius Ou, Geoffrey Liu, Hidetoshi Hayashi, Alessandra Bearz, Konstantin Penkov, Yi-Long Wu, Oscar Arrieta, Jacek Jassem, Anna M. Calella, Gerson Peltz, Anna Polli, Holger Thurm, and Tony Mok
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Cancer Research ,Oncology - Abstract
PURPOSE Lorlatinib significantly improved progression-free survival (PFS) versus crizotinib and showed robust intracranial activity in patients with previously untreated advanced ALK-positive non–small-cell lung cancer (NSCLC) in the phase III CROWN trial. Here, we report post hoc efficacy outcomes in patients with and without brain metastases at baseline, and present data on the incidence and management of CNS adverse events (AEs) in CROWN. METHODS Eligible patients were randomly assigned 1:1 to first-line lorlatinib (100 mg once daily) or crizotinib (250 mg twice a day); no crossover between treatment arms was permitted. Tumor assessments, including CNS magnetic resonance imaging, were performed at screening and then at 8-week intervals. Regular assessments of patient-reported outcomes were conducted. RESULTS PFS by blinded independent central review was improved with lorlatinib versus crizotinib in patients with and without brain metastases at baseline (12-month PFS rates: 78% v 22% and 78% v 45%, respectively). Lorlatinib was associated with lower 12-month cumulative incidence of CNS progression versus crizotinib in patients with (7% v 72%) and without (1% v 18%) brain metastases at baseline. In total, 35% of patients had CNS AEs with lorlatinib, most of grade 1 severity. Occurrence of CNS AEs did not result in a clinically meaningful difference in patient-reported quality of life. At analysis, 56% of CNS AEs had resolved (33% without intervention; 17% with lorlatinib dose modification), and 38% were unresolved; most required no intervention. Lorlatinib dose modification did not notably influence PFS. CONCLUSION First-line lorlatinib improved PFS outcomes and reduced CNS progression versus crizotinib in patients with advanced ALK-positive non–small-cell lung cancer with or without brain metastases at baseline. Half of all CNS AEs resolved without intervention or with lorlatinib dose modification.
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- 2022
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21. Preparation and Evaluation of Mebendazole 5% Antiparasitic Suspension for Veterinary Use
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Ferial Majed, Hashim Wahib, Orooba M. Saeed, Ahmed Al-Joubary, Noor Laith, and Mohammed Jassem
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The purpose of this study is to prepare a new formulation of Mebendazole suspension for veterinary therapeutic and antiparasitic use at a concentration of 5% of the poorly water soluble drug mebendazole using suspending agents, dispersing agents such as tween 80, polypropylene glycol, preservatives, and other salts to titrate the PH of the resulting mixtures. Information about all the materials used in the preparation of the formula was collected from pharmacopeia, while materials were provided by Samarra Company. and prepared about three formulae, from which the final one prepared. A study was conducted on the stability of the new formula in different temperature conditions (40, 50, and 60) °C by comparing any change in physicochemical properties concerning form, viscosity, and pH in different storage rooms and other temperatures for 18 months. showed that The results of the new drug proved its stability, both quantitative and qualitative results for suspension 5% formula as well as its physicochemical properties and viscosity tested and also conducted clinically therapy in the central veterinary hospital the findings demonstrate that Mebendazol is a promising new formulation of it for treatment of hydatid diseases without showing significantly liver toxicity.
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- 2022
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22. Estimation Hazard of Lung Cancer Due to Radiate Radon Gas in Diyala Governorate Schools
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Mothana Jassem Kadhim and Sameera Ahmed Ebrahiem
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General Engineering - Abstract
In this research, the concentration of radon gas has been calculated in the classrooms of schools in Diyala Governorate by using the nuclear track detector (CR-39), which was one of the organic solid-state nuclear detectors (SSNTDs). After calculating the radon gas concentration, the lung cancer cases were calculated. The results showed that the lowest value was found in (Alshumue) school (4.753) people. In contrast, the highest value was found in (Habhib) school (20.421). The average values of lung cancer cases in Diyala governorate were equal to (9.319) per person. The results showed that the number of lung cancer cases per year per million persons in Diyala Governorate schools was below the allowed limit from (ICRP) agency (170-230) people.
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- 2022
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23. Applied remote sensing technique, and GIS to choose suitable Geopark in south east Iraq
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null Masar Mahmood Khalf AL-Saedi, null Sahar T. Almulla, and null Riaed S. Jassem
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Pharmacology ,Drug Discovery ,Pharmaceutical Science - Abstract
Sentinel satellite images are enhanced using Erdas-2014 and analyzed by GIS techniques to distinguish the main geological features in the study area. The enhancement process and correct satellite image with Topography, Geomorphology, and Lithology characterize for landscape classify. GIS method environmental, geological, hydrological, and topographic analysis .to identified and assess the suitable location of Geopark in the eastern masian area. This study shows the east misan area has many suitable sites that can be developed as Geopark. By GIS method can choose the suitable Geopark that achieves the basic requirements set by UNESCO for the establishment of Geopark. It includes The existence of wildlife or watery Presence of geological, geophysical, or hydrological factors Hydrogeology is of importance in the region, and high Geodiversity, the area is of importance to ecotourism, The presence of archaeological sites in the region.
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- 2022
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24. The response of barley varieties and its companion weed to spraying with chemical herbicides
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Nesoor Adil Jassem and Suhad Mathkoor A. Safi
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A field experiment was carried out to evaluate the efficiency of selected weed herbicides in controlling the growing weed with barley.The experiment was carried out using randomized complete block design, by split plots arrangement with three replicates. The results showed the superiority of the mixture of herbicides (U 46 1 L.ha-1) + (Axial 1.5 L.ha-1) (H1 ) by giving the best weed control, where this treatment reduced the number of weeds in the experiment to give 0.00 plant.m-2. It also gave the best control percentages by 100% that was reflected in giving the best grain yield of 1.57 ton.ha-1, whose results were close to the treatment of hand weeding. Besides, the variety Iba 265 achieved the best results compared to the other varieties used in the study, as it gave the highest grain yield of 1.82 ton.ha-1 compared to the control treatment which gave the lowest grain yield amounted to 0.98 ton.ha-1.
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- 2022
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25. Guidelines of the Polish Respiratory Society on the Diagnosis and Treatment of Progressive Fibrosing Interstitial Lung Diseases Other than Idiopathic Pulmonary Fibrosis
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Wojciech Piotrowski, Magdalena Martusewicz-Boros, Adam Białas, Adam Barczyk, Bogdan Batko, Katarzyna Błasińska, Piotr Boros, Katarzyna Górska, Piotr Grzanka, Ewa Jassem, Dariusz Jastrzębski, Janina Kaczyńska, Otylia Kowal-Bielecka, Eugeniusz Kucharz, Jan Kuś, Barbara Kuźnar-Kamińska, Brygida Kwiatkowska, Renata Langfort, Katarzyna Lewandowska, Barbara Mackiewicz, Sebastian Majewski, Joanna Makowska, Joanna Miłkowska-Dymanowska, Elżbieta Puścińska, Alicja Siemińska, Małgorzata Sobiecka, Renata Soroka-Dąda, Małgorzata Szołkowska, Elżbieta Wiatr, Dariusz Ziora, and Paweł Śliwiński
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Pulmonary and Respiratory Medicine - Abstract
The recommendations were developed as answers to previously formulated questions concerning everyday diagnostic and therapeutic challenges. They were developed based on a review of the current literature using the GRADE methodology. The experts suggest that PF-ILD be diagnosed based on a combination of different criteria, such as the aggravation of symptoms, progression of radiological lesions, and worsening of lung function test parameters. The experts recommend a precise diagnosis of an underlying disease, with serological testing for an autoimmune disease always being included. The final diagnosis should be worked out by a multidisciplinary team (MDT). Patients with an interstitial lung disease other than IPF who do not meet the criteria for the progressive fibrosis phenotype should be monitored for progression, and those with systemic autoimmune diseases should be regularly monitored for signs of interstitial lung disease. In managing patients with interstitial lung disease associated with autoimmune diseases, an opinion of an MDT should be considered. Nintedanib rather than pirfenidon should be introduced in the event of the ineffectiveness of the therapy recommended for the treatment of the underlying disease, but in some instances, it is possible to start antifibrotic treatment without earlier immunomodulatory therapy. It is also admissible to use immunomodulatory and antifibrotic drugs simultaneously. No recommendations were made for or against termination of anti-fibrotic therapy in the case of noted progression during treatment of a PF-ILD other than IPF. The experts recommend that the same principles of non-pharmacological and palliative treatment and eligibility for lung transplantation should be applied to patients with an interstitial lung disease other than IPF with progressive fibrosis as in patients with IPF.
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- 2022
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26. Patient-reported outcomes with olaparib plus abiraterone versus placebo plus abiraterone for metastatic castration-resistant prostate cancer: a randomised, double-blind, phase 2 trial
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Fred Saad, Antoine Thiery-Vuillemin, Pawel Wiechno, Boris Alekseev, Nuria Sala, Robert Jones, Ivo Kocak, Vincenzo Emanuele Chiuri, Jacek Jassem, Aude Fléchon, Charles Redfern, Jinyu Kang, Joseph Burgents, Christopher Gresty, Arnold Degboe, and Noel W Clarke
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Male ,Prednisolone ,Pain ,Androgen Antagonists ,Docetaxel ,Prostate-Specific Antigen ,Piperazines ,Prostatic Neoplasms, Castration-Resistant ,Double-Blind Method ,Oncology ,Antineoplastic Combined Chemotherapy Protocols ,Androgens ,Quality of Life ,Humans ,Phthalazines ,Prednisone ,Androstenes ,Testosterone ,Patient Reported Outcome Measures - Abstract
Results of this double-blind, phase 2 trial showed patients with metastatic castration-resistant prostate cancer given olaparib plus abiraterone versus placebo plus abiraterone had significantly improved progression-free survival. Here, we present an exploratory analysis of pain and health-related quality of life (HRQOL).This double-blind, randomised, placebo-controlled, phase 2 trial was conducted across 41 urological oncology sites in 11 countries in Europe and North America. Eligible patients were aged 18 years or older, had metastatic castration-resistant prostate cancer, and had previously received docetaxel and up to one additional line of previous chemotherapy. Metastatic castration-resistant prostate cancer was defined as increasing prostate-specific antigen (PSA) concentration or other signs of disease progression despite androgen-deprivation therapy and serum testosterone concentrations at castrate levels (≤50 ng/dL), and with at least one metastatic lesion on bone scan, CT, or MRI. Eligible patients were randomly assigned (1:1) to receive oral olaparib (300 mg twice per day) plus oral abiraterone (1000 mg once a day) and oral prednisone or prednisolone (5 mg twice a day) or placebo plus abiraterone (1000 mg once a day) and prednisone or prednisolone (5 mg twice a day). Randomisation was done without stratification and by use of an interactive voice or web response system. A randomised treatment kit ID number was assigned sequentially to each patient as they became eligible. The primary endpoint (radiographic progression-free survival) has previously been reported. HRQOL was a prespecified exploratory patient-reported outcome. Patients were asked to complete the Brief Pain Inventory-Short Form (BPI-SF), single-item worst bone pain, Functional Assessment of Cancer Therapy-Prostate (FACT-P) questionnaire, and EuroQol-5 five-dimension five level (EQ-5D-5L) assessment at baseline, at weeks 4, 8, and 12, then every 12 weeks until treatment discontinuation. Prespecified outcomes were change from baseline in BPI-SF worst pain, single-item worst bone pain and FACT-P Total Outcome Index (TOI) scale scores, time to deterioration in BPI-SF worst pain and worst bone pain, and assessment of the EQ-5D-5L pain and discomfort domain. All analyses were exploratory and done in the full analysis set (all randomly assigned patients, including patients who were randomly assigned but did not subsequently go on to receive study treatment), with the exception of mean baseline and total change from baseline analyses, for which we used the population who had a valid baseline and at least one post-baseline assessment. This trial is registered with Clinicaltrials.gov, NCT01972217, and is no longer recruiting patients.Between Nov 25, 2014, and July 14, 2015, 171 patients were assessed for eligibility. 29 patients were excluded, and 142 were enrolled and randomly assigned to receive olaparib and abiraterone (n=71) or placebo and abiraterone (n=71). Data cutoff was Sept 22, 2017. Median follow-up was 15·9 months (IQR 8·1-25·5) in the olaparib plus abiraterone group and 24·5 months (8·1-27·6) in the placebo plus abiraterone group. Questionnaire compliance was generally high (43-100%). Least-squares mean changes from baseline in BPI-SF worst pain, single-item worst bone pain, and FACT-P TOI remained stable across all visits for patients in both treatment groups. Adjusted mean change in FACT-P TOI from baseline across all visits was -0·10 (95% CI -2·50 to 2·71) in the olaparib plus abiraterone group and -1·20 (-4·15 to 1·74) in the placebo plus abiraterone group (difference 1·30, 95% CI -2·70 to 5·30; p=0·52). Time to deterioration in pain was similar in both groups (BPI-SF worst pain HR 0·90 [95% CI 0·62-1·32], p=0·30; worst bone pain HR 0·85 [0·59-1·22], p=0·18). Improvement rates in the pain and discomfort domain of the EQ-5D-5L were similar in both groups from baseline to week 48, beyond which a higher proportion of patients in the olaparib plus abiraterone arm reported an improvement compared to the placebo plus abiraterone group.In these prespecified exploratory analyses, there was no significant difference in pain or HRQOL when olaparib was added to abiraterone. In this phase 2 trial, a statistically significant radiographic progression-free survival benefit was observed with the olaparib plus abiraterone combination. These results suggest that the improved survival benefits observed when combining olaparib with abiraterone does not result in different HRQOL compared with placebo plus abiraterone. Phase 3 studies are required to validate these results.AstraZeneca and Merck Sharpamp; Dohme, a subsidiary of Merckamp; Co, Rahway, NJ, USA.
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- 2022
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27. Modelling of Novel Architecture of PV Generator Based on a-Si: H/c-Si Materials and Using Solar Tracker for Partial Shading
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Mourad Talbi, Nawel Mensia, Jassem Arfaoui, and Abdelmajid Zairi
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General Medicine - Abstract
The purpose of this study is to investigate the shading effect on a novel architecture of photovoltaic generator (PVG) proposed in this paper. This architecture consists of three photovoltaic (PV) modules in series connected. Two of them consist of amorphous silicon cells in series connected. The third module consists of monocrystalline silicon cells in series connected. This architecture is conceived as a PV concentrator, where the two amorphous PV modules are located in the lower position, and the third one is located in the upper position precisely in the focus. The role of the upper module is to absorb the solar rays, which are reflected by the two other modules to gain the maximum of solar energy. This novel architecture is aimed at solving the problems existing with the architecture of tandem solar cells proposed in literature. Those problems are the mismatch between cells and the tunnel junction costs and fabrication. In this work, we use MATLAB/Simulink for modelling this architecture and studying its characteristics (I–V and P–V) in case of partial shading. Through this study, it was found that the maximum PV power is affected by the partial shading. To solve this problem, we have implemented in this work a solar tracker.
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- 2022
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28. Data from Three-Gene Expression Signature Predicts Survival in Early-Stage Squamous Cell Carcinoma of the Lung
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Rafael Rosell, Jacek Jassem, Laia Perez-Roca, Imane Chaib, Bartomeu Massuti, Mariano Provencio, David Jablons, Dan Raz, Grazyna Gulida, Witold Rzyman, Pedro Mendez, Jose Javier Sanchez, Miquel Taron, Ewa Jassem, and Marcin Skrzypski
- Abstract
Purpose: Adjuvant treatment may improve survival in early-stage squamous cell carcinoma (SCC) of the lung; however, the absolute gain is modest and mainly limited to stage II-IIIA. Current staging methods are imprecise indications of prognosis, but high-risk patients can be identified by gene expression profiling and considered for adjuvant therapy.Experimental Design: The expression of 29 genes was assessed by reverse transcriptase quantitative PCR in frozen primary tumor specimens obtained from 66 SCC patients who had undergone surgical resection. Expression values were dichotomized using the median as a cutoff value. We used a risk score to develop a gene expression model for the prediction of survival.Results: The univariate analysis of gene expression in the training cohort identified 10 genes with significant prognostic value: CSF1, EGFR, CA IX, PH4, KIAA0974, ANLN, VEGFC, NTRK1, FN1, and INR1. In the multivariate Cox model, CSF1 (hazard ratio, 3.5; P = 0.005), EGFR (hazard ratio, 2.7; P = 0.02), CA IX (hazard ratio, 0.2; P < 0.0001), and tumor size >4 cm (hazard ratio, 2.7; P = 0.02) emerged as significant markers for survival. The high prognostic value of a risk score based on the expression of the three genes (CSF1, EGFR, and CA IX) was positively validated in a separate cohort of 26 patients in an independent laboratory (P = 0.05).Conclusions: The three-gene signature is strongly associated with prognosis in early-stage SCC. Positive independent validation suggests its suitability for selecting SCC patients with an increased risk of death who might benefit from adjuvant treatment.
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- 2023
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29. Supplementary Data from Three-Gene Expression Signature Predicts Survival in Early-Stage Squamous Cell Carcinoma of the Lung
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Rafael Rosell, Jacek Jassem, Laia Perez-Roca, Imane Chaib, Bartomeu Massuti, Mariano Provencio, David Jablons, Dan Raz, Grazyna Gulida, Witold Rzyman, Pedro Mendez, Jose Javier Sanchez, Miquel Taron, Ewa Jassem, and Marcin Skrzypski
- Abstract
Supplementary Data from Three-Gene Expression Signature Predicts Survival in Early-Stage Squamous Cell Carcinoma of the Lung
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- 2023
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30. Using remote sensing techniques and analytical hierarchy process to select rainwater harvesting optimum sites: a case study in Ali Al-Garbi city, Iraq
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Zahraa R. Fakher, Sahar T. Al-Mulla, and Riaed S. Jassem
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General Computer Science ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology - Abstract
The assignment of suitable sites for water harvesting techniques is a promoted strategy to be introduced to the community, for handling the water scarcity and risk due to floods. In the eastern part of Missan, water is always hampered due to the limited availability during the drought, while floods frequently and intensely occur in the wet season. This study aimed to choose the potential and suitable sites for applied water harvesting system using remote sensing techniques and analytic hierarchy process (AHP). Ali Al-Garbi city is divided into three watersheds (site1, site2, and site3), which have been characterized by flash floods that produce high quantities of runoff. The six parameters: slope, lineament density, drainage density, soil texture, rainfall, and runoff. These factors are selected based on previous studies to detect the potential zones of water harvesting system in the study area.Pairwise comparison method consistency index, consistency ratio, and parametersweight is evaluated. The result discovers that the highly probable zone is situated in the north and north-eastern portions in watershed no.1 and watershed no.2, while watershed no.3 located in the south portions. In contrast, the low to medium WH is situated in the center and south portion in watershed no.1 and watershed no.2, whereas in watershed no.3 located in the north.
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- 2022
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31. Numerical and Experimental Study of Multi-layer Armors for Personal Protection
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Ahmed Ehsan Jassem, Akram Jassim Jawad, Ahmed Oleiwi Samarmad, and Ahmed Fadhil Hamzah
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General Materials Science ,Physical and Theoretical Chemistry ,Condensed Matter Physics - Abstract
Currently, personal armor is considered the basic requirement in combat, especially in the Middle East. The current research attempts to design and manufacture a novel body armor from cheap and available materials. When compared to traditional materials’ body armor, composite ballistic body armor has become a superior alternative for personal protection. In this study, alternative materials were proposed to develop an armor consisting of modified rubber and ebonite, as well as pieces of ceramic from alumina as hexagons shape, Kevlar and Carbon woven, and modern technologies shear thickening fluids. The armor was numerically evaluated using (ANSYS) commercial software using different bullet velocities ranging from (740 to 940) m/s and different numbers of carbon and Kevlar woven soaking shear thickening fluids to reach the best arrangement of layers with the best performance and compare them in the experimental data. The numerical results show the best performance for plate armor consisting of 23-layers, which were then experimentally tested using a weapon type (AK-47) rifle with bullet 7.62*39 mm. The experimental test showed no complete penetration, with a back deformation of 7.5 mm. When the shock of the double bullet into the plate at the same location showed no complete penetration with a back deformation of 11.3 mm, the body armor exhibited superior protective performance and was compatible with standard NIJ Standard-0101.03.
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- 2022
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32. Assessment of vessels endothelial dysfunction by protease-activated receptors (PARs) signaling in COVID-19 patients
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Muntadher Ali Jassem, Rana M. Hameed, and Hassan Fasil
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General Nursing ,Education - Abstract
PAR-1-mediated the endothelial disruption that occurs in the context of thromboinflammation. In addition, PAR1 promotes a profibrotic phenotype in fibroblasts, alveolar inflammation, and apoptosis. This is an active area of research; more data are needed to clarify similarities and differences of the PARs and their modulators in Post and Critical cases of COVID-19. Such issues are especially relevant given the potential use PAR-1 as a marker of promote thrombosis and tissue injury through a proposed mechanism between inflammation and thrombosis that was reported previously. This paper would track the theoretical role of PAR-1 as a marker of promote thrombosis in COVID-19 cases by looking for the following questions: What is the Cross Talk Between Thromboinflammation and Protease-activated receptors during Post and Critical cases of COVID-19?
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- 2022
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33. GRAPHIC DESIGN CONCEPT OF SOCIAL DISTANCE
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Nsiyf Jassem
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General Medicine - Abstract
It is admirable for design and designers to deal with events and to reveal a lot of what they see as interesting, and this is not new, because all the events that humanity has experienced have been the best resource for design, especially those that take a global public character, and our world today is witnessing one of several events that had an impact The spread of (Coronavirus) is an important event, and the design and related companies had a presence in expressing some of the requirements to prevent it and limit its spread, and this was accompanied by many health names, from That social distancing, which is described as one of the ways that can enhance the preventive role, that is why some international companies considered a position that is important in making minor changes to the structures of their brands as a formal, semantic portable that directs people to preserve their lives, as well as expressing a kind of solidarity with people Especially those who are injured. The current research talks about the graphic design and the concept of social distance that was commonly heard in the Corona crisis, or what is called social distancing, based on the question that: Has the graphic design played a role in promoting the values of social distance in light of the health pandemic, and the importance of the research lies in the following: - Theoretical dimension: It can be useful in strengthening the theoretical framework of the graphic design process and the healthy value promotion it witnessed in light of the Corona crisis. - Applied dimension: it can benefit those interested and working in the matter of graphic design, and the research aims to: Know the graphic design and the concept of social distance in light of the health crisis, and for the importance of the research puts the following keywords: Graphic design, social distance, corona pandemic The theoretical framework includes the following topics: -The concept of social distance -Design and concept -Designers during a pandemic.
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- 2022
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34. Spatial variation of the unemployed population in Anbar Governorate for the year 2019
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Ziyad Badran Jassem and Bilal Bardan Ali
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- 2022
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35. Thermal and mechanical study of polymeric composites prepared from epoxy with iron filings
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Maysam K. Jassem Al-Atrash and Ebtahag Z. Sulyman Al Halim
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General Nursing ,Education - Abstract
Through this research, polymeric composites were prepared from Addition of epoxy resin with iron filings in certain weight ratios (0.5%,1%,1.5%,2%,2.5%,3%,4%,4.5%,5%) as a reinforcement material. The comparison was made between polymeric composites Before and after the cementing process , After a series of experiments, it was found that the best weight percentage was (1%),This addition was done at different temperatures (8,25,55) °C, The results when compared before and after the reinforcement process for the composites showed that the thermal conductivity the thermal conductivity increased after the strengthening process, for the mechanical properties, Impact test, Hardness and compressive strength, they increased at 25°C and increased at processing temperatures(8.55)°C.
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- 2022
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36. relationship between visceral adiposity tissue and functional exercise capacity among type 2 diabetes
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Mohammed Salih Jassem and Hamady Jabbar Mahmood
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General Nursing ,Education - Abstract
Aim: To compare the visceral adiposity index and functional exercise capacity between type 2 diabetes mellitus and healthy controls, as well as find out the relationship between visceral adiposity index and functional exercise capacity among type 2 diabetes patients. Methods: Using a purposive sampling strategy, this case-control study included 62 subjects: 31 with T2DM and 31 with healthy controls. All the participants were nonsmokers with no pulmonary problems that could have influenced the 6MWT. Age, sex, and BMI were matched to each of the T2DM and healthy controls. We assessed demographic, anthropometric, and biochemical variables. Based on 6MWD, the maximum oxygen consumption (VO2 max) was estimated. The waist circumference (WC), BMI, serum triglyceride, and high-density lipoprotein (HDL) cholesterol levels were used to calculate the VAI. Descriptive and inferential statistics were used to analyze the data. P was chosen as the alpha level < 0.05. Results: The mean and standard deviations of 6MWD estimated VO2 max and VAI were (445.6 +78.7) for T2DM vs (529.7+70.1) for healthy controls, (17.1+7.6) vs (23.2 +5.7), and (3.2+1.4) vs (1.9 +0.8), respectively, while VAI and 6MWD had a negative correlation (r =-0.728 at P-value =0.000).
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- 2022
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37. Complex EGFR mutations in non-small cell lung cancer: a distinct entity?
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Michał Bieńkowski, Rafał Dziadziuszko, and Jacek Jassem
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Pulmonary and Respiratory Medicine - Published
- 2022
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38. Novel Benchmark Values for Redo Liver Transplantation
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Fariba Abbassi, Daniel Gero, Xavier Muller, Alba Bueno, Wojciech Figiel, Fabien Robin, Sophie Laroche, Benjamin Picard, Sadhana Shankar, Tommy Ivanics, Marjolein van Reeven, Otto B. van Leeuwen, Hillary J. Braun, Diethard Monbaliu, Antoine Breton, Neeta Vachharajani, Eliano Bonaccorsi Riani, Greg Nowak, Robert R. McMillan, Samir Abu-Gazala, Amit Nair, Rocio Bruballa, Flavio Paterno, Deborah Weppler Sears, Antonio D. Pinna, James V. Guarrera, Eduardo de Santibañes, Martin de Santibañes, Roberto Hernandez-Alejandro, Kim Olthoff, R Mark Ghobrial, Bo-Göran Ericzon, Olga Ciccarelli, William C. Chapman, Jean-Yves Mabrut, Jacques Pirenne, Beat Müllhaupt, Nancy L. Ascher, Robert J. Porte, Vincent E. de Meijer, Wojciech G. Polak, Gonzalo Sapisochin, Magdy Attia, Olivier Soubrane, Emmanuel Weiss, René A. Adam, Daniel Cherqui, Karim Boudjema, Krzysztof Zieniewicz, Wayel Jassem, Philipp Dutkowski, Pierre-Alain Clavien, Surgery, Faculteit Medische Wetenschappen/UMCG, Groningen Institute for Organ Transplantation (GIOT), UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, and UCL - (SLuc) Service de chirurgie et transplantation abdominale
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End Stage Liver Disease ,retransplantation ,Benchmarking ,Tissue and Organ Procurement ,Treatment Outcome ,benchmark ,Graft Survival ,Humans ,Surgery ,redo liver transplantation ,Liver Transplantation ,Retrospective Studies - Abstract
Objective In the era of organ shortage, redo liver transplantation (reLT) is frequently discussed in terms of expected poor outcome, high cost and therefore wasteful resources. However, there is a lack of benchmark data to reliably assess outcomes after reLT. The aim of this study was to define the ideal reLT case, and to establish clinically relevant benchmark values for best achievable outcome in reLT. Methods We collected data on reLT between January 2010 and December 2018 from 22 high volume transplant centers on three continents. Benchmark cases were defined as recipients with model of end-stage liver disease score Results Out of 1110 reLT 413 (37.2%) qualified as benchmark cases. Benchmark values included: Length of intensive care unit and hospital stay: =3a complications and the CCI at 1 year: Conclusion ReLT remains associated with high morbidity and mortality. The availability of benchmark values for outcome parameters of reLT may serve for comparison in any future analyses of individuals, patient groups, or centers, but also in the evaluation of new therapeutic strategies and principles.
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- 2022
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39. Prospective study of Na[18F]F PET/CT for cancer staging in morbidly obese patients compared with [99mTc]Tc-MDP whole-body planar, SPECT and SPECT/CT
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Usmani, Sharjeel, Ahmed, Najeeb, Gnanasegaran, Gopinath, Al kandari, Fareeda, Marafi, Fahad, Bani-Mustafa, Ahmed, Musbah, Ahmed, Almashmoum, Maryam Jassem, and Van den Wyngaert, Tim
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Oncology ,Radiology, Nuclear Medicine and imaging ,Hematology ,General Medicine - Abstract
This prospective study aims to assess the diagnostic test characteristics of Na[18F]F PET/CT for the skeletal staging of cancer in morbidly obese patients compared with 99mTc-methylene diphosphonate (MDP), whole-body planar (WBS), SPECT, and SPECT/CT acquisitions. One hundred seventeen obese patients (BMI 46.5 ± 6.1 kg/m2 and mean age, 59.0 years; range 32–89 years) with BMI > 40 kg/m2 were prospectively enrolled and underwent [99mTc]Tc-MDP WBS, SPECT, SPECT/CT, and Na[18F]F PET/CT within two weeks for the osseous staging of a malignancy. Images were assessed qualitatively using a 3-point scale. Patient and lesion-based diagnostic test characteristics were estimated using an optimistic and pessimistic dichotomization method. Bone metastases were confirmed in 44 patients. Patient-based optimistic diagnostic test characteristics were (sensitivity, specificity, overall accuracy): Na[18F]F PET/CT (95.5%, 95.9%, 95.7%), [99mTc]Tc-MDP WBS (52.3%, 71.2%, 64.1%), SPECT (61.4%, 80.8%, 73.5%) and SPECT/CT (65.9%, 91.8%, 82.1%). Lesion-based optimistic diagnostic test characteristics were: Na[18F]F PET/CT (97.7%, 97.9%, 97.7%), [99mTc]Tc-MDP WBS (39%, 67%, 48.9%), SPECT (52.9%, 93.6%, 67.3%) and SPECT/CT (65.9%, 91.8%, 82.1%). There was no significant difference in the specificity of Na[18F]F and SPECT/CT. All other pairwise comparisons were significant (p18F]F with significantly higher AUCs for Na[18F]F PET/CT compared to [99mTc]Tc-MDP WBS, SPECT, and SPECT/CT on both patient and lesion-based analysis (p18F]F PET/CT changed patient management in 38% of patients. Na[18F]F PET/CT may be the preferred imaging modality for skeletal staging in morbidly obese patients. The technique provides excellent diagnostic test characteristics superior to [99mTc]Tc-MDP bone scan (including SPECT/CT), impacts patient management, has an acceptable radiation exposure profile, and is well-tolerated. Further cost-effectiveness evaluations are warranted.
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- 2022
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40. Measuring the Concentration of Radon Gas in Book Stores in Primary Schools in Diyala Governorate
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Mothana Jassem Kadhim and Sameera Ahmed Ebrahiem
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General Engineering - Abstract
In this research, the concentration of radon gas was calculated in the book store rooms of schools in Diyala Governorate, it was calculated by Solid State Nuclear Track Detectors (SSNTDS) when the detector (CR-39) was used, the detector was placed and suspended at a distance of 160 cm from the surface of the earth, and the detector was exposed for 30 days to record alpha tracks. The results of radon concentration showed that the highest concentration percentage was found in (Eishtar) school, which was equal to (84.896) Bq/m3, while the lowest value was recorded in (Habhib) school, which was equal to (11.242) Bq/m3, where the concentration rate was equal to (28.158) Bq/m3. When we compared our results with the global results, we found that the calculated radon concentrations are much less than the internationally permissible limits recorded by (ICRP), which were in the range of (200-300) Bq/m3.
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- 2022
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41. Predicting the Outcome of Obstructive Sleep Apnea Syndrome in Iraqi Patients Over 30 Years of Age
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Dr. Bakr Mohammed Mahdi and Dr. Saad Messer Jassem Aljanabi
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Sleep apnea syndrome (OSAHS) ,ESS degree ,STOP-Bang degree ,and AHI - Abstract
Background: An adult sleep disease called obstructive sleep apnea-hypopnea syndrome (OSAHS) can be defined by the partial or total collapse of the upper airway while the patient is asleep. OSAHS is now more common in older individuals than middle-aged men and women globally, with prevalence rates of 2% and 4%, respectively. Aim: This paper was predicting the outcome of obstructive sleep apnea syndrome in Iraqi patients over 30 years of age. Patients and methods: A cross-sectional study was conducted to predict the outcome of obstructive sleep apnea syndrome in Iraqi patients over the age of thirty. This study was submitted for a period between the 15th of July in the year 2021 to the 24th of April in the year 2022 in different hospitals in Iraq. This study contributed to study accuracy. To comparison of the predicted model and the group to ESS and stop-bang as well as in different types of blood pressure. Our data was designed and built using the SPS program. Results and discussion: This paper was focused on prediction the outcome of obstructive sleep apnea syndrome in Iraqi patients over 30 years of age. Our results found that almost targeted patients above 40 years where our results got that almost of the patients’ cases were male (67.5%) and more that female (32.5%). Furthermore, this paper was examined the symptoms were found that episodes in which you stop breathing during sleep with (23) and Dry mouth upon awakening (5) patients cases. The study examined the data of blood pressure was found diastolic blood pressure was low with 8 (20%) and high (6) at 15%, which has 17 cases, while systolic blood pressure for apnea patients has 23 cases. Moreover, this study measured the accuracy of prediction model performance at 83.58%, ESS at 55.58% and 46.63%. Conclusion: Our study found that apnea had a big impact on males more than females where. Most studies have employed the AHI to assess the severity of obstructive sleep apnea (OSA) as well as the effectiveness of therapy. However, it doesn't appear to be a reliable indicator of illness severity or a tool for selecting a course of therapy in both clinical research and clinical practice. This study was found that sever level got more cases with (26) patients with mild level with 14 cases
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- 2023
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42. Neutral-point-clamped inverter based synchronous reluctance motor drive for solar pump application
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Rajini V., Jassem M., Nagarajan V.S., Sreeya Galla N.V. Sai, and Jeyapradha Rb
- Subjects
Electrical and Electronic Engineering ,Industrial and Manufacturing Engineering - Abstract
Purpose Industrial drives require appropriate control systems for reliable and efficient performance. With synchronous reluctance machines (SynRMs) slowly replacing the most commonly used induction, switched reluctance and permanent magnet machines, it is essential that the drive and its control be properly selected for enhanced performance. But the major drawback of synchronous reluctance motor is the presence of high torque ripple as its design is characterized by large number of variables. The solutions to reduce torque ripple include design modifications, choice of proper power electronic inverter and PWM strategy. But little has been explored about the power electronic inverters suited for synchronous reluctance motor drive to minimize torque ripple inherently by obtaining a more sinusoidal voltage. The purpose of this paper is to elaborate on the potential multilevel inverter topologies applicable to SynRM drives used in solar pumping applications. Design/methodology/approach The most significant field-oriented control using maximum torque per ampere algorithm for maximizing the torque production is used for the control of SynRM. Simulation results carried out using Matlab/Simulink are presented to justify the choice of inverter and its control technique for SynRM. Findings The five-level inverter drive gives lesser core or iron losses in the SynRMin comparison to the three- and two-level inverters due to lower Id current ripple. The five-level inverter reduces the torque ripple of the SynRM significantly in comparison to the three- and two-level inverter fed SynRM drives. The phase disposition-PWM control method used for the inverter shows the least total harmonic distortion (THD) levels in output voltage compared with the other level shifted PWM techniques. Originality/value Among the available topologies, a fitting topology is proposed for use for the SynRM drive to have minimal THD, minimal current and torque ripple. Additionally, this paper presents various modulation techniques available for the selected drive system and reports on a suitable technique based on minimal THD of output voltage and hence minimal torque ripple.
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- 2023
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43. Supplementary Table 1 from Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer
- Author
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Patricia S. Steeg, Rolf E. Swenson, Haitao Wu, Carolyn C. Woodroofe, Emilie Bialecki, Philippe Metellus, Priscilla K. Brastianos, Jacek Jassem, Renata Duchnowska, Rafał Pęksa, Michał Bieńkowski, Wojciech Biernat, Simone Difilippantonio, Christina M. Robinson, Anurag N. Paranjape, Brunilde Gril, and Imran Khan
- Abstract
Supplementary Table 1
- Published
- 2023
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44. Data from Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer
- Author
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Patricia S. Steeg, Rolf E. Swenson, Haitao Wu, Carolyn C. Woodroofe, Emilie Bialecki, Philippe Metellus, Priscilla K. Brastianos, Jacek Jassem, Renata Duchnowska, Rafał Pęksa, Michał Bieńkowski, Wojciech Biernat, Simone Difilippantonio, Christina M. Robinson, Anurag N. Paranjape, Brunilde Gril, and Imran Khan
- Abstract
Advances in drug treatments for brain metastases of breast cancer have improved progression-free survival but new, more efficacious strategies are needed. Most chemotherapeutic drugs infiltrate brain metastases by moving between brain capillary endothelial cells, paracellular distribution, resulting in heterogeneous distribution, lower than that of systemic metastases. Herein, we tested three well-known transcytotic pathways through brain capillary endothelial cells as potential avenues for drug access: transferrin receptor (TfR) peptide, low-density lipoprotein receptor 1 (LRP1) peptide, albumin. Each was far-red labeled, injected into two hematogenous models of brain metastases, circulated for two different times, and their uptake quantified in metastases and uninvolved (nonmetastatic) brain. Surprisingly, all three pathways demonstrated distinct distribution patterns in vivo. Two were suboptimal: TfR distributed to uninvolved brain but poorly in metastases, while LRP1 was poorly distributed. Albumin distributed to virtually all metastases in both model systems, significantly greater than in uninvolved brain (P < 0.0001). Further experiments revealed that albumin entered both macrometastases and micrometastases, the targets of treatment and prevention translational strategies. Albumin uptake into brain metastases was not correlated with the uptake of a paracellular probe (biocytin). We identified a novel mechanism of albumin endocytosis through the endothelia of brain metastases consistent with clathrin-independent endocytosis (CIE), involving the neonatal Fc receptor, galectin-3, and glycosphingolipids. Components of the CIE process were found on metastatic endothelial cells in human craniotomies. The data suggest a reconsideration of albumin as a translational mechanism for improved drug delivery to brain metastases and possibly other central nervous system (CNS) cancers.In conclusion, drug therapy for brain metastasis needs improvement. We surveyed three transcytotic pathways as potential delivery systems in brain-tropic models and found that albumin has optimal properties. Albumin used a novel endocytic mechanism.
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- 2023
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45. Supplementary Figure S1-S10 from Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer
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Patricia S. Steeg, Rolf E. Swenson, Haitao Wu, Carolyn C. Woodroofe, Emilie Bialecki, Philippe Metellus, Priscilla K. Brastianos, Jacek Jassem, Renata Duchnowska, Rafał Pęksa, Michał Bieńkowski, Wojciech Biernat, Simone Difilippantonio, Christina M. Robinson, Anurag N. Paranjape, Brunilde Gril, and Imran Khan
- Abstract
Supplementary Figures S1-S10
- Published
- 2023
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46. Supplementary Material and Methods from Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer
- Author
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Patricia S. Steeg, Rolf E. Swenson, Haitao Wu, Carolyn C. Woodroofe, Emilie Bialecki, Philippe Metellus, Priscilla K. Brastianos, Jacek Jassem, Renata Duchnowska, Rafał Pęksa, Michał Bieńkowski, Wojciech Biernat, Simone Difilippantonio, Christina M. Robinson, Anurag N. Paranjape, Brunilde Gril, and Imran Khan
- Abstract
Supplementary Material and Methods
- Published
- 2023
- Full Text
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47. Tonsillectomy and the Study of General Complications in Addition to the Assessment of Bleeding and Quality of Life for Patients in Iraq
- Author
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Dr. Ahmed Sh Muhialdin, Dr. Bakr Mohammed Mahdi, and Dr. Saad Messer Jassem Aljanabi
- Subjects
Tonsillitis ,BMI ,type of Hemorrhage ,Comorbidities ,and Adenotonsillectomy surgery - Abstract
Background: Removal of the palatine tonsils is a frequently performed operation in patients with chronic tonsillitis. The proportion of tonsillectomy in otorhinolaryngological practice is up to 10% or more of all surgical interventions. Objective: This study aims to analyze Tonsillectomy and the study of general complications in addition to the assessment of bleeding and quality of life for patients in Iraq. Patients and method: This study was conducted by making a cross-sectional study of patients with tonsillectomy, where this study focused on the analysis of Tonsillectomy and the study of general complications in addition to the assessment of bleeding and quality of life for patients in Iraq. This study was applied to patients between the ages of younger than 20 to older than 35 years of age, for both sexes, male and female, in different hospitals in Iraq for a study that ranged from the 7th of July 2021 to the 14th of April 2022. This study examined and analyzed all the data collected through the use of the program SPSS. The study data were divided into two groups, where the first group represented Bleeder patients, which included 72 patients, and the second group included non-bleeder patients, which included 64 patients. Discussion: Although tonsillectomy is a very common surgical procedure in otolaryngology practice, many efforts have been made to reduce its associated morbidity and mortality, especially in relation to post-tonsillectomy hemorrhage; because this analysis was retrospective in nature, we did not include potential intraoperative risk factors for post-tonsillectomy hemorrhages, such as the presence of fibrosis and the volume of intraoperative bleeding, because these data were inconsistently accessible in the operating reports. The risk of post-tonsillectomy bleeding was considerably higher among individuals having a history of chronic tonsillitis, older patients, major intraoperative blood loss, and postoperative hypertension. Conclusion: Post-tonsillectomy bleeding is a significant consequence that frequently necessitates intraoperative hemorrhage management and may necessitate blood transfusions, especially in individuals with a history of chronic tonsillitis. Age, Hematocrit, Diabetes, and Hypertension were shown in our study to be risk factors for post-tonsillectomy bleeding in the group of patients who bled, which led to a decline in the patient's assessments of their quality of life. The risk of post-tonsillectomy bleeding was considerably higher among individuals having a history of chronic tonsillitis, older patients, major intraoperative blood loss, and postoperative hypertension.
- Published
- 2023
- Full Text
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48. Simple approximation of sample size for precise estimates of SARS-CoV-2 infection from point-seroprevalence studies
- Author
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A M, Nikiforuk, I, Sekirov, and A N, Jassem
- Subjects
Seroepidemiologic Studies ,SARS-CoV-2 ,Sample Size ,Prevalence ,Public Health, Environmental and Occupational Health ,Humans ,COVID-19 ,General Medicine - Abstract
This study aimed to model the precision of SARS-CoV-2 seroprevalence estimates.Sample size and precision estimates were calculated using the normal approximation to the binomial distribution. The relationship between sample size and precision was visualized across a range of assumed SARS-CoV-2 seroprevalence from 2% to 75%.The calculation found that 2% precision was attainable by taking moderately sized sample sets when the expected seroprevalence of SARS-CoV-2 infection exceeds 2%. In populations with a low incidence of SARS-CoV-2 infection and an expected seroprevalence of less than 2%, larger samples are required for precise estimates.Taking a sample of 177-1000 participants can provide precise prevalence estimates of SARS-CoV-2 infection in vaccinated and unvaccinated populations. Larger sample sizes are only necessary in low prevalence settings.
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- 2022
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49. Study the Correlation between Pathogenic Parasitic Infections and Infertility among Women in Kerbala province, Iraq
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Kawther A. M. Al-Mussawi, Sawsan K. Abbas, Muna I. Jassem, and Inam J. Radhi
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Pharmaceutical Science - Abstract
This study indicated that infections with pathogenic–parasitic (PP) causes in healthy controls who do not suffer infertility will be higher than those of infertile women. Correspondingly, in parasitic infections in (protozoa) were prevalent among numerous parts of the world. Developed countries and infertile women were the major burden and infections, for example, the women’s reproductive system through damage to infertile women. There were approximately parasitic infections such as Trichomonas vaginalis could reason cervical tumors, non-anomalous pelvic infections in women and tubal and genital tract abnormalities. Toxoplasma gondii reasons dysplasia of reproductive tract, synthetic disorders and endometriosis for example, intrauterine adhesions.
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- 2022
- Full Text
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50. حفيظ الله أمين ودوره السياسي في أفغانستان 16أيلول 1979 – 27 كانون الاول 1979
- Author
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null Dr. Alaa Kazem Jassem and null Dr. Muhannad Kazem Rasheed
- Abstract
تتناول هذه الدراسة شخصية حفيظ الله أمين ودوره السياسي في أفغانستان كأحد الشخصيات الجدلية التي أثيرت حولها الشكوك والادعاءات في سياستها الداخلية والخارجية التي اتاحت الفرصة لواشنطن لإيجاد قوة وتهديد للمصالح السوفيتية في أفغانستان والحدود الجنوبية للاتحاد السوفيتي في عهده ، واستطاع في مدة قليلة نسبيا من تصدر المشهد السياسي على حساب أقرانه من السياسيين، بيد أن الامر لم يدم طويلا ، فسرعان ما اصطدمت أحلام حفيظ الله أمين بالواقع السياسي والعسكري المتأزم داخل البلاد فضلا عن والشكوك السوفيتية بولاء حفيظ حفيظ الله أمين لهم ، تزامن ذلك كله مع المنافسة الداخلية له من خصومه في الحزب هذه العوامل وغيرها عجلت برحيله من السلطة.
- Published
- 2022
- Full Text
- View/download PDF
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