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1. Disentangling the genetics of lean mass

Author

Karasik, David, Zillikens, M Carola, Hsu, Yi-Hsiang, Aghdassi, Ali, Akesson, Kristina, Amin, Najaf, Barroso, Inês, Bennett, David A, Bertram, Lars, Bochud, Murielle, Borecki, Ingrid B, Broer, Linda, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos-Obando, Natalia, Cauley, Jane A, Cawthon, Peggy M, Chambers, John C, Chen, Zhao, Cho, Nam H, Choi, Hyung Jin, Chou, Wen-Chi, Cummings, Steven R, de Groot, Lisette CPGM, De Jager, Phillip L, Demuth, Ilja, Diatchenko, Luda, Econs, Michael J, Eiriksdottir, Gudny, Enneman, Anke W, Eriksson, Joel, Eriksson, Johan G, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Gieger, Christian, Grallert, Harald, Gudnason, Vilmundur, Lenore, Launer J, Hayward, Caroline, Hofman, Albert, Homuth, Georg, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Johnson, Toby, Biffar, Reiner, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koller, Daniel L, Kooner, Jaspal S, Kraus, William E, Kritchevsky, Stephen, Kutalik, Zoltán, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Lerch, Markus M, Lewis, Joshua R, Lill, Christina, Lind, Lars, Lindgren, Cecilia, Liu, Yongmei, Livshits, Gregory, Ljunggren, Östen, Loos, Ruth JF, Lorentzon, Mattias, Luan, Jian'an, Luben, Robert N, Malkin, Ida, McGuigan, Fiona E, Medina-Gomez, Carolina, Meitinger, Thomas, Melhus, Håkan, Mellström, Dan, Michaëlsson, Karl, Mitchell, Braxton D, Morris, Andrew P, Mosekilde, Leif, Nethander, Maria, Newman, Anne B, O'Connell, Jeffery R, Oostra, Ben A, Orwoll, Eric S, Palotie, Aarno, Peacock, Munro, and Perola, Markus

Subjects
Adult, Male, meta-analysis of genome-wide association studies, Adolescent, European Continental Ancestry Group, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Medical and Health Sciences, White People, Young Adult, Versicans, ADAMTS Proteins, Engineering, Electric Impedance, 80 and over, Genetics, Humans, 2.1 Biological and endogenous factors, Absorptiometry, Polymorphism, Aetiology, skeletal muscle, Aged, Extracellular Matrix Proteins, body composition, Nutrition & Dietetics, Prevention, Human Genome, RNA-Binding Proteins, Skeletal, Body Fluid Compartments, Single Nucleotide, Middle Aged, Photon, metabolic profile, body fat, Phenotype, Adipose Tissue, Melanocortin, Muscle, Female, Type 4, Receptor, Genome-Wide Association Study
Abstract

BackgroundLean body mass (LM) plays an important role in mobility and metabolic function. We previously identified five loci associated with LM adjusted for fat mass in kilograms. Such an adjustment may reduce the power to identify genetic signals having an association with both lean mass and fat mass.ObjectivesTo determine the impact of different fat mass adjustments on genetic architecture of LM and identify additional LM loci.MethodsWe performed genome-wide association analyses for whole-body LM (20 cohorts of European ancestry with n=38,292) measured using dual-energy X-ray absorptiometry) or bioelectrical impedance analysis, adjusted for sex, age, age2, and height with or without fat mass adjustments (Model 1 no fat adjustment; Model 2 adjustment for fat mass as a percentage of body mass; Model 3 adjustment for fat mass in kilograms).ResultsSeven single-nucleotide polymorphisms (SNPs) in separate loci, including one novel LM locus (TNRC6B), were successfully replicated in an additional 47,227 individuals from 29 cohorts. Based on the strengths of the associations in Model 1 vs Model 3, we divided the LM loci into those with an effect on both lean mass and fat mass in the same direction and refer to those as "sumo wrestler" loci (FTO and MC4R). In contrast, loci with an impact specifically on LM were termed "body builder" loci (VCAN and ADAMTSL3). Using existing available genome-wide association study databases, LM increasing alleles of SNPs in sumo wrestler loci were associated with an adverse metabolic profile, whereas LM increasing alleles of SNPs in "body builder" loci were associated with metabolic protection.ConclusionsIn conclusion, we identified one novel LM locus (TNRC6B). Our results suggest that a genetically determined increase in lean mass might exert either harmful or protective effects on metabolic traits, depending on its relation to fat mass.

Published
2019

2. Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits

Author

Teumer, Alexander, Qi, Qibin, Nethander, Maria, Aschard, Hugues, Bandinelli, Stefania, Beekman, Marian, Berndt, Sonja, Bidlingmaier, Martin, Broer, Linda, Cappola, Anne, Ceda, Gian Paolo, Chanock, Stephen, Chen, Ming-Huei, Chen, Tai, Chen, Yii-Der Ida, Chung, Jonathan, Del Greco Miglianico, Fabiola, Eriksson, Joel, Ferrucci, Luigi, Friedrich, Nele, Gnewuch, Carsten, Goodarzi, Mark, Grarup, Niels, Guo, Tingwei, Hammer, Elke, Hayes, Richard, Hicks, Andrew, Hofman, Albert, Houwing-Duistermaat, Jeanine, Hu, Frank, Hunter, David, Husemoen, Lise, Isaacs, Aaron, Jacobs, Kevin, Janssen, Joop, Jansson, John-Olov, Jehmlich, Nico, Johnson, Simon, Juul, Anders, Karlsson, Magnus, Kilpelainen, Tuomas, Kovacs, Peter, Kraft, Peter, Li, Chao, Linneberg, Allan, Liu, Yongmei, Loos, Ruth, Lorentzon, Mattias, Lu, Yingchang, Maggio, Marcello, Magi, Reedik, Meigs, James, Mellström, Dan, Nauck, Matthias, Newman, Anne, Pollak, Michael, Pramstaller, Peter, Prokopenko, Inga, Psaty, Bruce, Reincke, Martin, Rimm, Eric, Rotter, Jerome, Saint Pierre, Aude, Schurmann, Claudia, Seshadri, Sudha, Sjögren, Klara, Slagboom, P Eline, Strickler, Howard, Stumvoll, Michael, Suh, Yousin, Sun, Qi, Zhang, Cuilin, Svensson, Johan, Tanaka, Toshiko, Tare, Archana, Tönjes, Anke, Uh, Hae-Won, Van Duijn, Cornelia, van Heemst, Diana, Vandenput, Liesbeth, Vasan, Ramachandran, Völker, Uwe, Willems, Sara, Ohlsson, Claes, Wallaschofski, Henri, Kaplan, Robert, Chen, Ming‐Huei, Chen, Yii‐Der Ida, Houwing‐Duistermaat, Jeanine, Jansson, John‐Olov, Slagboom, P. Eline, Uh, Hae‐Won, Heemst, Diana, King‘s College London, Harvard School of Public Health, Azienda Sanitaria Firenze, Laboratoire Interuniversitaire des Systèmes Atmosphériques (LISA (UMR_7583)), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS), National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Endocrine Research Unit, Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany, RS: CARIM - R1.06 - Genetic Epidemiology and Genomics of cardiovascular diseases, RS: FHML MaCSBio, Biochemie, Internal Medicine, and Epidemiology

Subjects
0301 basic medicine, Male, Aging, MESH: Insulin-Like Growth Factor I, IGFBP3, Genome-wide association study, Regulatory Sequences, Nucleic Acid, Cardiovascular, Medical and Health Sciences, MESH: Quantitative Trait, Heritable, 2.1 Biological and endogenous factors, MESH: Aging, Insulin-Like Growth Factor I, Aetiology, Genetics, [STAT.AP]Statistics [stat]/Applications [stat.AP], MESH: Insulin-Like Growth Factor Binding Protein 3, 11 Medical And Health Sciences, Biological Sciences, growth hormone axis, MESH: Gene Expression Regulation, IGF-I, Metabolome, Female, Erratum, [STAT.ME]Statistics [stat]/Methodology [stat.ME], MESH: Metabolome, CHARGE Longevity Working Group, Adult, Quantitative Trait Loci, Single-nucleotide polymorphism, Locus (genetics), Body Composition Genetics Consortium, Quantitative trait locus, Biology, 03 medical and health sciences, Quantitative Trait, Quantitative Trait, Heritable, longevity, Clinical Research, SNP, MESH: Regulatory Sequences, Nucleic Acid, Humans, Allele, Heritable, Metabolic and endocrine, genomewide association study, MESH: Humans, Nucleic Acid, aging, MESH: Adult, IGFBP-3, Cell Biology, 06 Biological Sciences, MESH: Quantitative Trait Loci, MESH: Male, 030104 developmental biology, Insulin-Like Growth Factor Binding Protein 3, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Gene Expression Regulation, Expression quantitative trait loci, MESH: Genome-Wide Association Study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], MESH: Female, Regulatory Sequences, Genome-Wide Association Study, Developmental Biology
Abstract

The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30?884 adults of European ancestry from 21 studies, we confirmed and extended the list of previously identified loci associated with circulating IGF-I and IGFBP-3 concentrations (IGF1, IGFBP3, GCKR, TNS3, GHSR, FOXO3, ASXL2, NUBP2/IGFALS, SORCS2, and CELSR2). Significant sex interactions, which were characterized by different genotype-phenotype associations between men and women, were found only for associations of IGFBP-3 concentrations with SNPs at the loci IGFBP3 and SORCS2. Analyses of SNPs, gene expression, and protein levels suggested that interplay between IGFBP3 and genes within the NUBP2 locus (IGFALS and HAGH) may affect circulating IGF-I and IGFBP-3 concentrations. The IGF-I-decreasing allele of SNP rs934073, which is an eQTL of ASXL2, was associated with lower adiposity and higher likelihood of survival beyond 90?years. The known longevity-associated variant rs2153960 (FOXO3) was observed to be a genomewide significant SNP for IGF-I concentrations. Bioinformatics analysis suggested enrichment of putative regulatory elements among these IGF-I- and IGFBP-3-associated loci, particularly of rs646776 at CELSR2. In conclusion, this study identified several loci associated with circulating IGF-I and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known (FOXO3) and novel (ASXL2) longevity-associated loci. ? 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Published
2016
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3. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Author

Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie AM, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, and Liu, Yongmei

Subjects
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

A correction to this article has been published and is linked from the HTML version of this article.

Published
2017

4. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Author

Zillikens, M Carola, Demissie, Serkalem, Hsu, Yi-Hsiang, Yerges-Armstrong, Laura M, Chou, Wen-Chi, Stolk, Lisette, Livshits, Gregory, Broer, Linda, Johnson, Toby, Koller, Daniel L, Kutalik, Zoltán, Luan, Jian'an, Malkin, Ida, Ried, Janina S, Smith, Albert V, Thorleifsson, Gudmar, Vandenput, Liesbeth, Hua Zhao, Jing, Zhang, Weihua, Aghdassi, Ali, Åkesson, Kristina, Amin, Najaf, Baier, Leslie J, Barroso, Inês, Bennett, David A, Bertram, Lars, Biffar, Rainer, Bochud, Murielle, Boehnke, Michael, Borecki, Ingrid B, Buchman, Aron S, Byberg, Liisa, Campbell, Harry, Campos Obanda, Natalia, Cauley, Jane A, Cawthon, Peggy M, Cederberg, Henna, Chen, Zhao, Cho, Nam H, Jin Choi, Hyung, Claussnitzer, Melina, Collins, Francis, Cummings, Steven R, De Jager, Philip L, Demuth, Ilja, Dhonukshe-Rutten, Rosalie AM, Diatchenko, Luda, Eiriksdottir, Gudny, Enneman, Anke W, Erdos, Mike, Eriksson, Johan G, Eriksson, Joel, Estrada, Karol, Evans, Daniel S, Feitosa, Mary F, Fu, Mao, Garcia, Melissa, Gieger, Christian, Girke, Thomas, Glazer, Nicole L, Grallert, Harald, Grewal, Jagvir, Han, Bok-Ghee, Hanson, Robert L, Hayward, Caroline, Hofman, Albert, Hoffman, Eric P, Homuth, Georg, Hsueh, Wen-Chi, Hubal, Monica J, Hubbard, Alan, Huffman, Kim M, Husted, Lise B, Illig, Thomas, Ingelsson, Erik, Ittermann, Till, Jansson, John-Olov, Jordan, Joanne M, Jula, Antti, Karlsson, Magnus, Khaw, Kay-Tee, Kilpeläinen, Tuomas O, Klopp, Norman, Kloth, Jacqueline SL, Koistinen, Heikki A, Kraus, William E, Kritchevsky, Stephen, Kuulasmaa, Teemu, Kuusisto, Johanna, Laakso, Markku, Lahti, Jari, Lang, Thomas, Langdahl, Bente L, Launer, Lenore J, Lee, Jong-Young, Lerch, Markus M, Lewis, Joshua R, Lind, Lars, Lindgren, Cecilia, and Liu, Yongmei

Subjects
Extracellular Matrix Proteins, 17-Hydroxysteroid Dehydrogenases, 1.1 Normal biological development and functioning, Quantitative Trait Loci, Human Genome, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Single Nucleotide, Aldehyde Oxidoreductases, Regulatory Elements, Phenotype, Versicans, ADAMTS Proteins, Thinness, Underpinning research, Body Composition, Insulin Receptor Substrate Proteins, Genetics, Humans, Transcriptional, Polymorphism, Genome-Wide Association Study
Abstract

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p

Published
2017

5. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Author

Kilpeläinen, Tuomas O, Carli, Jayne F Martin, Skowronski, Alicja A, Sun, Qi, Kriebel, Jennifer, Feitosa, Mary F, Hedman, Åsa K, Drong, Alexander W, Hayes, James E, Zhao, Jinghua, Pers, Tune H, Schick, Ursula, Grarup, Niels, Kutalik, Zoltán, Trompet, Stella, Mangino, Massimo, Kristiansson, Kati, Beekman, Marian, Lyytikäinen, Leo-Pekka, Eriksson, Joel, Henneman, Peter, Lahti, Jari, Tanaka, Toshiko, Luan, Jian'an, Del Greco M, Fabiola, Pasko, Dorota, Renström, Frida, Willems, Sara M, Mahajan, Anubha, Rose, Lynda M, Guo, Xiuqing, Liu, Yongmei, Kleber, Marcus E, Pérusse, Louis, Gaunt, Tom, Ahluwalia, Tarunveer S, Ju Sung, Yun, Ramos, Yolande F, Amin, Najaf, Amuzu, Antoinette, Barroso, Inês, Bellis, Claire, Blangero, John, Buckley, Brendan M, Böhringer, Stefan, I Chen, Yii-Der, de Craen, Anton JN, Crosslin, David R, Dale, Caroline E, Dastani, Zari, Day, Felix R, Deelen, Joris, Delgado, Graciela E, Demirkan, Ayse, Finucane, Francis M, Ford, Ian, Garcia, Melissa E, Gieger, Christian, Gustafsson, Stefan, Hallmans, Göran, Hankinson, Susan E, Havulinna, Aki S, Herder, Christian, Hernandez, Dena, Hicks, Andrew A, Hunter, David J, Illig, Thomas, Ingelsson, Erik, Ioan-Facsinay, Andreea, Jansson, John-Olov, Jenny, Nancy S, Jørgensen, Marit E, Jørgensen, Torben, Karlsson, Magnus, Koenig, Wolfgang, Kraft, Peter, Kwekkeboom, Joanneke, Laatikainen, Tiina, Ladwig, Karl-Heinz, LeDuc, Charles A, Lowe, Gordon, Lu, Yingchang, Marques-Vidal, Pedro, Meisinger, Christa, Menni, Cristina, Morris, Andrew P, Myers, Richard H, Männistö, Satu, Nalls, Mike A, Paternoster, Lavinia, Peters, Annette, Pradhan, Aruna D, Rankinen, Tuomo, Rasmussen-Torvik, Laura J, Rathmann, Wolfgang, Rice, Treva K, Brent Richards, J, Ridker, Paul M, Sattar, Naveed, and Savage, David B

Subjects
Leptin, Male, digestive, oral, and skin physiology, Messenger, Human Genome, Cardiovascular, Oral and gastrointestinal, Tissue Culture Techniques, Stroke, Mice, Adipose Tissue, Gene Expression Regulation, Clinical Research, Gene Knockdown Techniques, Genetics, Animals, RNA, 2.1 Biological and endogenous factors, Obesity, Aetiology, hormones, hormone substitutes, and hormone antagonists, Metabolic and endocrine, Genome-Wide Association Study, Nutrition, Cancer
Abstract

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P

Published
2016

6. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

Author

Kilpelainen, Tuomas O., Martin-Carli, Jayne Frances, Skowronski, Alicja Anna, Sun, Qi, Kriebel, Jennifer, Feitosa, Mary F., Hedman, Asa K., Drong, Alexander W., Hayes, James E., Zhao, Jinghua, Pers, Tune H., Schick, Ursula, Grarup, Niels, Kutalik, Zolt��n, Trompet, Stella, Mangino, Massimo, Kristiansson, Kati, Beekman, Marian, Lyytik��inen, Leo-Pekka, Eriksson, Joel, Henneman, Peter, Lahti, Jari, Tanaka, Toshiko, Luan, Jian���an, Del Greco M, Fabiola, Pasko, Dorota, Renstr��m, Frida, Willems, Sara M., Mahajan, Anubha, Rose, Lynda M., Guo, Xiuqing, Liu, Yongmei, Kleber, Marcus E., P��russe, Louis, Gaunt, Tom, Ahluwalia, Tarunveer S., Sung, Yun Ju, Ramos, Yolande F., Amin, Najaf, Amuzu, Antoinette, Barroso, In��s, Bellis, Claire, Blangero, John, Buckley, Brendan M., B��hringer, Stefan, Chen, Yii-Der I., de Craen, Anton J. N., Crosslin, David R., Dale, Caroline E., Dastani, Zari, Day, Felix R., Deelen, Joris, Delgado, Graciela E., Demirkan, Ayse, Finucane, Francis M., Ford, Ian, Garcia, Melissa E., Gieger, Christian, Gustafsson, Stefan, Hallmans, G��ran, Hankinson, Susan E., Havulinna, Aki S., Herder, Christian, Hernandez, Dena, Hicks, Andrew A., Hunter, David J., Illig, Thomas, Ingelsson, Erik, Ioan-Facsinay, Andreea, Jansson, John-Olov, Jenny, Nancy S., J��rgensen, Marit E., J��rgensen, Torben, Karlsson, Magnus, Koenig, Wolfgang, Kraft, Peter, Kwekkeboom, Joanneke, Laatikainen, Tiina, Ladwig, Karl-Heinz, LeDuc, Charles A., Lowe, Gordon, Lu, Yingchang, Marques-Vidal, Pedro, Meisinger, Christa, Menni, Cristina, Morris, Andrew P., Myers, Richard H., M��nnist��, Satu, Nalls, Mike A., Paternoster, Lavinia, Peters, Annette, Pradhan, Aruna D., Rankinen, Tuomo, Rasmussen-Torvik, Laura J., Rathmann, Wolfgang, Rice, Treva K., Richards, J. Brent, Ridker, Paul M., Sattar, Naveed, Savage, David B., S��derberg, Stefan, Timpson, Nicholas J., Vandenput, Liesbeth, van Heemst, Diana, Uh, Hae-Won, Vohl, Marie-Claude, Walker, Mark, Wichmann, Heinz-Erich, Wid��n, Elisabeth, Wood, Andrew R., Yao, Jie, Zeller, Tanja, Zhang, Yiying, Meulenbelt, Ingrid, Kloppenburg, Margreet, Astrup, Arne, S��rensen, Thorkild I. A., Sarzynski, Mark A., Rao, D. C., Jousilahti, Pekka, Vartiainen, Erkki, Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, Andr�� G., Kajantie, Eero, Osmond, Clive, Palotie, Aarno, Eriksson, Johan G., Heli��vaara, Markku, Knekt, Paul B., Koskinen, Seppo, Jula, Antti, Perola, Markus, Huupponen, Risto K., Viikari, Jorma S., K��h��nen, Mika, Lehtim��ki, Terho, Raitakari, Olli T., Mellstr��m, Dan, Lorentzon, Mattias, Casas, Juan P., Bandinelli, Stefanie, M��rz, Winfried, Isaacs, Aaron, van Dijk, Ko W., van Duijn, Cornelia M., Harris, Tamara B., Bouchard, Claude, Allison, Matthew A., Chasman, Daniel I., Ohlsson, Claes, Lind, Lars, Scott, Robert A., Langenberg, Claudia, Wareham, Nicholas J., Ferrucci, Luigi, Frayling, Timothy M., Pramstaller, Peter P., Borecki, Ingrid B., Waterworth, Dawn M., Bergmann, Sven, Waeber, G��rard, and Vollenweider, Peter

Subjects
Leptin, Meta-analysis, Molecular biology, FOS: Biological sciences, digestive, oral, and skin physiology, Genetics, hormones, hormone substitutes, and hormone antagonists
Abstract

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P

Published
2016
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7. Interleukin 6 receptor alpha is expressed in the melanin-concentrating hormone-containing neurons of the human hypothalamus

Author

Jansson John-Olov

Subjects
medicine.medical_specialty, Chemistry, General Neuroscience, Interleukin 5 receptor alpha subunit, Interleukin, Interleukin 1 receptor, type II, Interleukin 10 receptor, alpha subunit, Endocrinology, Interleukin-4 receptor, Internal medicine, Interleukin-6 receptor, medicine, Interleukin 1 receptor, type I, Interleukin 12 receptor, beta 1 subunit
Published
2010

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