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BACKGROUND: During the coronavirus 2019 (COVID-19) pandemic, academicians were juggling their personal and professional life amid lockdown while trying to deliver maximum knowledge through online classes. This chronic stress is emotionally draining and can eventually lead to burnout. OBJECTIVE: To examine the levels of perceived stress and burnout and examine the effects of self-efficacy and coping in reducing stress and preventing burnout in academicians during the COVID-19 lockdown. METHODS: This survey included 63 physiotherapy academicians from various physiotherapy colleges in India. Assessments used to collect data were the Perceived Stress Scale, Oldenburg Burnout Inventory, General Perceived Self-Efficacy Scale, and the Brief Resilient Coping Scale. The data was collected through Google Forms and sent through an online mode via various social media apps. RESULTS: This study revealed that the majority of the physiotherapy academicians were experiencing moderate levels of stress eventually leading to burnout. Stress levels were higher in academicians with more than 10 years of experience. Also, self-efficacy and resilient coping were negatively correlated with perceived stress and burnout. CONCLUSION: Academicians experienced increasing amounts of stress during the COVID-19 pandemic, which, if not addressed on time, can lead to job burnout.

Infertility and obstetric complications have become global health issues in the past few years. Infertility is defined as the inability of a couple to conceive even after twelve months or more of regular and unprotected intercourse. According to WHO data published in the year 2020, 186 million people have infertility globally. Factors leading to infertility are variable in both males and females. But some common factors include smoking, alcohol consumption, obesity, and stress. Various synthetic drugs and treatment options are available that are effective in treating infertility, but their prolonged usage produces various unwanted adverse effects like hot flashes, mood swings, headaches, and weight gain. In extreme cases, these may also lead to the development of anxiety and depression. Herbal remedies have gained a lot of popularity over the years, and people’s inclination toward them has increased all over the world. The prime reason is that these show significant therapeutic efficacy and have fewer side effects. The therapeutic efficacy of plants can be attributed to the presence of diverse phytochemical classes of constituents like alkaloids, flavonoids, and volatile oils. These secondary metabolites, or phytomolecules, can be used to develop herbal formulations. The review highlights the applications and mechanisms of action of various phytochemicals for treating infertility. Also, it focuses on the various future prospects associated with it.

Objective: Long-lasting migraine pain is one of the most disabling neurological disorders and requires a quick onset of action from the administered dosage form. This study aimed to provide sublingual administration of the frequently used combination of NSAID and triptan in order to trigger their action immediately by escaping the first-pass metabolism, simultaneously improving patient compliance. Methods: In the present research, sublingual bilayer films were developed by joining the two loaded layers with zolmitriptan and piroxicam, respectively. Each layer was prepared and loaded separately using the traditional solvent casting method. Mechanical support was provided by the 1:1 combination of HPMC E-15 and pullulan, which were used as water-soluble film-forming polymers with polyethylene glycol 400 as a plasticizer. Films were evaluated for various physicochemical and mechanical properties. Finally, a pharmacokinetic study was performed on six healthy human volunteers to compare the PK parameters of the best formulation, BSTF-3, with those of a commercially available formulation. Sepitrap 80 and Sepitrap 4000 were used as bio-enhancers to achieve faster systemic delivery. Results: The thin, flexible bilayer films were observed to provide quick action alone with increase patient compliance by preventing the first-pass metabolism and dysphagia. Sepitrap 80 successfully increased the permeation of both drugs. Approximately 92 percent of zolmitriptan was released from the formed bilayer sublingual thin films within 3 min, whereas 92 percent of piroxicam was released within 4.5 min from the best formulation. Within 30 min of the commencement of the pharmacokinetic investigation, plasma concentrations of the active component began to rise rapidly. Conclusion: When compared to commercial formulations, the developed films had a greater AUC and Cmax with a shorter Tmax, indicating a faster trigger of action and higher bioavailability.

Urinary tract infections are gaining much importance among community acquired infections. Poor personal hygiene may act as a contributory factor in such frequent infections in developing countries. The condition becomes serious with antimicrobial resistance among uropathogens. Specifically, surge of Extended Spectrum beta Lactamase (ESBL) producers poses much concern in the available treatment options. Present work was aimed to observe the bacteriological profile and antimicrobial susceptibility pattern of uropathogens with special reference to ESBL producing strains. This study was carried out in the microbiology department, SGT University, Gurugram, Haryana. Total 600 samples were processed as per standard bacteriological procedures i.e, microscopy, culture and biochemical reactions followed by antibiotic susceptibility testing and interpreted as per CLSI guidelines. ESBL producer strains were spotted by double disc synergy testing (DDST). Out of 600 specimens, 128( 21.3%) showed culture positivity. Females contributed more compared to males. 21-40 years age group showed highest isolation rate. E.coli was predominant organism. Highest resistance towards amikacin was shown by gram negative organisms. Gram positive organisms demonstrated high resistance towards gentamicin, cotrimoxazole, ampicillin and ciprofloxacin. 34.4% ESBL producing E.coli strains were observed. Alarming rate of antibiotic resistance as well as beta lactamase production by strains and increasing urinary tract infections should be considered as potential threat to the community. Routine investigation should be done to see the burden in order to implicate advance treatment policies in order to treat such infections.

Coronavirus disease 2019 (COVID19) is the recently reported disease caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID19 spreads among population through the close/direct contact and nasal droplets when an infected person sneezes, coughs, talks or breaths. On an average, COVID19 infected patient develops clinical symptoms 5-6 days after the infection and some develops symptoms even after 14 days of infection. Detailed study on the symptoms shown by COVID19 patients can help in identifying individuals so that proper identification and isolation of patients can be done and transmission of virus can be reduced significantly. In this study, a total of 99 (66 males and 33 female) COVID19 infected symptomatic patients without any comorbidities were included. Nasopharyngeal and oropharyngeal swabs were used for the collection of samples from the suspected patients to extract total RNA and perform real time PCR for the detection of genetic material for SARS-CoV-2. Samples with Ct value ≤ 36 in case of Orf1ab gene and E gene with good sigmoidal curve were reported as positive for novel SARS-CoV-2. Fever, shortness of breath, dry cough and cough with sputum production persisted for longer timer and were more common symptoms reported by the COVID19 infected patients. In conclusion, understanding of the clinical symptoms shown by COVID19 infected patients can help in identification and isolation of patients so that transmission of virus can be reduced significantly.

The ketogenic diet, which is low in carbohydrates, may help diabetic people reduce their medication and improve their glycemia. Obesity and diabetes are two of the most well-known metabolic diseases connected with unfortunate dietary patterns and a stationary way of life. In the direst outcome imaginable, metabolic issues are a contributing reason to a wide range of diseases. The ketogenic diet replaces glucose with ketone bodies and is useful in various conditions, including metabolic disorders, epileptic seizures, peripheral neuropathy, kidney cancer, and skeletal muscle atrophy. Obesity is connected to a higher risk of type two diabetes. In obese people with glucose intolerance, it has been discovered that successful weight management and dietary adjustments, particularly in terms of carbohydrate content and glycemic index, have favorable benefi ts. We’ve already demonstrated that a ketogenic diet could help you to lose weight. Furthermore, even in hyperlipidemic obese people, it improves cardiac risk factors. For a period of 56 weeks, the eff ect of low carbs or ketogenic diet was evaluated in patients having obesity with high glucose levels of blood to those with moderate blood glucose levels in this study. In many circumstances, excess insulin treatment and protein limitation slow the onset of diabetic nephropathy, and very few therapies are known to reverse nephropathy. The Keto diet regulates glucose and insulin levels in the body, making it an effi cient diabetes treatment. As a result, the keto diet can be used to demonstrate the gap between diabetes treatment and obesity. Obesity is connected to a higher risk diabetes of type 2. In obese people with glucose intolerance, it has been discovered that successful weight management and dietary adjustments, particularly in carbohydrate content and glycemic index, have favorable eff ects. Diabetic nephropathy was entirely restored after two months of following a ketogenic diet, as measured by albumin/creatinine ratios and stress-induced gene expression. On the other hand, histological evidence of nephropathy was only partially reversed. This shows that diabetic nephropathy can be restored with a relatively straightforward dietary change. It’s still unclear if the ketogenic diet’s benefi cial eff ects are mediated by lower glucose metabolism. Glycemic levels are aff ected by dietary changes. The low-carb ketogenic diet was found to be quite promising in managing diabetic mellitus in preliminary investigations.

Mung bean is a short-duration ancient legume crop that can be grown as a sole or intercrop for grain and green manure in all three crop seasons, including winter, summer and rainy in various regions of the country. MYMV (Mungbean Yellow Mosaic Virus) disease is one of the most destructive diseases transmitted by whitefly (Bemisia tabaci Genn) persistently. Weather parameters have no direct effect on MYMV, but affect the whitefly population. Field experiments were conducted for three consecutive years from 2019-2021 as to know the effect of weather parameters on the whitefly population. Development of whitefly population and MYMV disease severity were recorded in mungbean crops at 7 days interval starting from 20 days after sowing (DAS). The present study showed that whitefly population builds up starting in July and reached to maximum at end of August to early September. There are various factors influencing the build-up of whitefly population viz., maximum temperature 36±2°C, minimum temperature 25±2°C, morning relative humidity more than 90 percent, more sunshine hours and no rainfall prevailing during that period. Whitefly population had positive significant correlation with maximum temperature and bright sunshine hours while evening relative humidity and rainfall were recorded as negatively significant. Three-year data is very helpful in guiding the farmers for timely and preventive sprays based on existing infections and the population of whitefly in a season.

Dormancy in seeds is defined as the failure of seeds to germinate despite the presence of all necessary conditions for germination. It is caused by the impermeability of the hard seed coat or a lack of availability and activity of germination-essential enzymes. Seeds undergo a variety of physical and chemical pre-treatments to break their dormancy. It results into lower seed germination rate and poor growth. To overcome this drawback various treatments are given to the seeds before sowing this study reviews some of the pre-sowing practices and the effects they have on seed germination and growth. Scientists are quite concerned about seed dormancy; hence it is a research topic of interest to develop an effective solution. All viable seeds are capable of germinating if the proper pre-sowing treatment is used.

This study demonstrates for the first time the different excitonic behaviour of snowlike and hexagonal MoSe2 at low temperatures along with the dominance of three-phonon (four-phonon) scattering for thermal transport in hexagonal (snowlike) MoSe2.

Structural analysis of guanidinium–amino acid interaction pairs in protein crystal structures is coupled with an effective scheme for classifying the optimized pairs, to gain understanding of the guanidinium:protein hydrogen bonding modes.

In this research study, iron nanoparticles (FeNPs) were synthesized using Gymnema sylvestre (Asclepiadaceae) leaves extract. Iron(III) ions present in ammonium ferrous sulphate hexahydrate were reduced to FeNPs by phytoconstituents in Gymnema sylvestre leaves extract. The characteristics of biosynthesized FeNPs were studied by using UV-visible absorption spectroscopy (UV-vis), transmission electron microscopy (TEM), particle size analyzer (PSA) and Fourier transform infrared spectroscopy (FTIR). The typical absorption peak was found to lie within 650-700 nm due to the excitation of surface plasmon vibration in FeNPs. The spherical structures of FeNPs were found in the range of 8-40 nm with average particle size of 405.8 nm. The antibacterial study of the biosynthesized FeNPs was performed against Gram-positive (B. subtilis) bacteria and Gram-negative (E. coli) bacteria by the agar well dispersion technique. The zone of inhibition of antibacterial activity of FeNPs against B. subtilis and E. coli bacteria was found to be 27.5 and 29 mm, respectively.

Researchers are very concerned about addressing or managing the growing problem of global warming or climate change. Global warming is caused by greenhouse gases, of which carbon dioxide (CO2) alone contributes 60%. By absorbing carbon dioxide (CO2) during photosynthesis and naturally storing it as biomass, trees serve as a sink for CO2 because trees have the ability to store carbon and can lessen the effects of climate change and global warming, planting trees or restoring forests may be a solution to this growing problem. This review paper can be helpful since it discusses the interaction between arbuscular mycorrhizal fungi (AMF) and the roots of trees, which benefits the plant for better germination and growth. dormancy of seeds or a delay in growth can be identified as a disadvantage in a plantation program. With the hope that this information would advance the field of research, we have concentrated on mycorrhizal association and its impact on different species of trees in this work. It can be useful for tree species that have lower biomass or slower growth.

In conquest to attain the goal of zero hunger as well as tackling the problem of malnutrition worldwide, fish proves to be one of the best functional food to humans. Along with the sense of good taste to humans, it ensures great nutritional value at an affordable price. Fish food plays an active role in providing nutrients to the body that are directly involved in metabolic activities. It is enriched with high quality protein containing all the essential amino acids, omega-3 polyunsaturated fatty acids including eicosapentanoic acid and docosahexaenoic acid. Also, it provides wide variety of micronutrients involving vitamins (fat soluble vitamins and several members of vitamin B complex) and minerals. Also, these have significant protective effects against the occurrences of several diseases such as cancer, cardiovascular diseases, inflammatory diseases, retinopathy, diabetes, arthritis and some other acute or chronic diseases. The bioactive peptides from fish food are reported for their positive effect on humans. Therefore, fish is an optimal choice of food to humans as it helps in their growth, development and maintenance of good health. However, care should be taken during processing of fish or fish products as the inappropriate handling can deteriorate the nutritional quality of the food.

Melia composita (Burma dek) is one of the multipurpose fast growing tree species applicable for the agri-silviculture system. In northern India, due to its fast growing and short rotation nature it has developed one of chosen tree species by the farmers under agroforestry. Melia composita occurs mostly in tropical moist and dry deciduous forest of Himalayas. The seed have Hard endocarp and therefore quite difficult to germinate. There are different types of seed dormancy and it helps in find out the better pre-sowing treatment to assure early and uniform germination of seeds. This leads to minimize the cost of large scale seedlings production. The present study was conducted at Laboratory of Seed Science and Technology, CCS Haryana Agricultural University during 2019 to evaluate the “Effect of pre-sowing treatments on seed germination of Melia composita”. Five pre-sowing treatments viz., normal water soaking (24, 48 and 72hr), conc. H2SO4 (5, 10 and 15 min.), cow dung slurry (5, 10 and 15 days), boiling water (5, 10 and 15 min.), mechanical scarification + GA3 (100 ppm) (8, 16 and 24hr). In laboratory conditions, maximum germination (64.67 %) and seed viability (74.67%) were recorded in concentrated H2SO4 treatment at 15 minute, whereas maximum root length (7.54 cm), shoot length (16.72 cm), root: shoot ratio and seedling dry weight (0.65g) were recorded in mechanical scarification + GA3 (100 ppm) at 24 hr.

The germplasms of African and French marigold were screened at Research Farm Area, Department of Horticulture, CCS Haryana Agricultural University, Hisar, Haryana against the two spotted spider mite, Tetranychus urticae (TSSM) in the winter season from first week of October to first week of March, 2018. The germplasm tall orange African sheltering lowest mite population (9.82 mites/leaf) was marked as the least susceptible and Hisar Jafari-2 French with 32.21 mites/leaf was categorized as highly susceptible for T. urticae infestation. Mite population was recorded weekly and significantly higher number of mites was recorded on grown up leaves followed by tender and older leaves of marigold plants. Irrespective of the germplasm, the mite number was found to significantly increase with each observation period till the attainment of peak in population in the month of January (35.51 mites/ leaf) while their least population was recorded in the month of October (6.65 mites/leaf). In general, French germplasms were comparatively more susceptible to T. urticae infestation as compared to African germplasms.

Since the beginning of the nineteenth century, the Narmada River Valley has been well known for discoveries of abundant vertebrate fossil localities, a wide range of prehistoric archaeological assemblages and the first-known hominin fossil site in India at Hathnora. The fossil and archaeological remains are found in various sedimentary contexts: boulder conglomerate, pebble-rich sand, cross-bedded, coarse-to-fine sand and reddish brown clay in the Early to Late Pleistocene deposits. Our preliminary field investigations in the Narsinghpur region of the basin mark the presence of 26 individual localities within a stretch of 70 km of the Narmada River and adjoining tributaries. Each location was documented by GPS and the geological details were recorded while collecting the fossils. Past and current palaeontological research has revealed that a variety of fauna adapted to the sub-humid climate of both aquatic and terrestrial landscapes that thrived in this area during the Pleistocene period. One of our long-term goals is to understand the reasons for the high number of palaeontological occurrences compared with other parts of India and use such information to predict the locations of new occurrences, including hominin fossils. Various taphonomic processes in this region are responsible for the preservation and destruction of fossil assemblages in different geological formations: soil type, climatic conditions, rich calcium carbonate presence, encrustation, patination and modern anthropogenic activities (among others). Most of the fossil localities are found at an elevation range of 310–350 m above mean sea level (AMSL). The Narmada Basin was inhabited by prehistoric human populations and a variety of fauna, as evidenced by the ample lithic and fossil assemblages across the region. There are definitive contextual patterns of occurrences of the Quaternary vertebrate fossils and archaeological assemblages in the landscape, which require detailed investigations and mapping to understand the spatial distribution pattern and nature of associated sedimentary environments. In addition, this uniquely fossil-rich area requires proper protection and long-term preservation as it is heavily impacted by modern anthropogenic factors such as agriculture, sand mining and other activities.

In this modern era, print consistency is being considered of greater significance which needs to be frequently evaluated. This print consistency is correlated to various technical aspects while printing, amongst these ink density of secondary colour, play an important role and contribute significantly during printing. Hence it becomes necessary to understand the behaviour of ink density while using different methodologies. This present analysis is to explicate the ink density behaviour and delineate the ink density variations on matt paper using different methodologies during printing.

Extensive dispersal of the pesticides to shield the different types of vegetation from pests has increased the production but at the same it has resulted in an increase in environmental pollution. Consequently, it is necessary to eliminate these undesired pollutants from the environment. The current investigation offers the synthesis of humic acid-coated magnetite nanoparticles towards effective removal of the most common insecticide, imidacloprid, from aqueous solution using a batch adsorption method. These synthesized nanoparticles were characterized with the help of several analytical and spectroscopic techniques. To acquire the maximum conceivable adsorption, effects of different influencing parameters like pH of the solution, time of contact, concentration of pesticide solution, amount of adsorbent and temperature were also examined. Moreover, the kinetic studies were found to be in good agreement with a pseudo-second-order kinetic model supporting the occurrence of chemisorption phenomenon. Additionally, isotherm modeling proved that the adsorption process was in accordance with the Langmuir model of isotherm. Thermodynamic parameters depicted the endothermic and spontaneous behavior of the adsorption process. Desorption studies were also carried out to examine the reusability of these nano-adsorbents. These verdicts confirmed that the surface modified magnetite nanoparticles may be treated as proficient material for exclusion of imidacloprid from the aqueous solution.

In the current work, sublingual bilayer thin films (SBTFs) containing piroxicam and zolmitriptan, were prepared by solvent casting technique using HPMC E15, pullulan afterwards evaluated for their physicomechanical properties, disintegration time and in-vitro drug release. A single dose of formulated SBTFs containing piroxicam (10mg) and Zolmitriptan (2.5mg) was administered to healthy volunteers and their blood samples were withdrawn at predefined time interval for in-vivo pharmacokinetic studies. Plasma concentration of drugs were analysed using a validated HPLC-MS/MS method. The pharmacokinetic parameters were obtained and compared with pharmacokinetic data of marketed formulation. The thickness, weight variation, folding endurance and pH of the films was found to be within the acceptable range. The in-vitro disintegration time varied from 27-45 sec and drug content was found to be 96.01- 100.62% for all the formulation. Formulation B3 showed drug release of 92% within 3-4.5 mins. The plasma concentration time curve helped in assessing the pharmacokinetic parameters i.e. AUC0-24, t1/2, Cmax, tmax, and Vd. The plasma concentration time profile of both drugs indicated the increase of AUC, bioavailability, elimination half-life and Vd when compared with the pharmacokinetic parameters of marketed formulation which helped in the rapid onset of action in the management of acute pain. The results suggested that plasma drug concentration of active ingredient started appearing in a significant amount within 30 minutes which indicated that the developed sublingual delivery system had effectively delivered the drug into the systemic circulation.

Whether scavenging or hunting, the consumption of large mammals is very prominent in the history of humankind. During the Lower Palaeolithic period, the abundance of large cutting tools found indicates increased meat consumption. Evidence has demonstrated this at various African and European sites where direct links between lithic and faunal assemblages have been made, for instance cut-marked bones and use-wear studies. On the Indian Subcontinent, there is a lack of direct evidence on animal remains in archaeological contexts (with one exception); however, there are numerous sites where animal fossils and lithic artefacts occur in shared contextual associations. The present paper is concerned with the relationships between the lithic and faunal assemblages in archaeological contexts, particularly the occurrence of bifaces and large mammalian fossils in Lower Palaeolithic assemblages with specific reference to the central Indian zone. Without the confirmation of anthropogenic signatures on Pleistocene faunal remains, it is not easy to assess whether a particular assemblage has the contemporaneous deposition of the two datasets or not. Here, we present a review of archaeological and faunal records in the central Narmada Valley and explore the possible associative evidence of human–animal interactions.

The aim of this research was to mask the bitter taste of Mebendazole using ion exchange resin and to formulate a taste masked chewable tablet. Kyron T-114 was used as a taste masking agent which was containing cross-linked polyacrylic backbone was used as taste masking agents. The drug resin complex was prepared by complexation of drug with resin using batch method. Maximum drug loading capacity of resins Kyron T-114 was calculated then Drug Resin Complexes were optimized by effect of drug resin ratio, Effect of stirring time. Effect of soaking time, effect of temperature and effect of pH on drug loading. Drug resin complex was evaluated for FTIR studies, drug release at salivary pH 6.8 and dissolution of drug resin complex at gastric pH. Taste masked chewable tablets of Mebendazole were prepared by direct compression method. Post compression evaluations used such as thickness, diameter, weight variation, hardness, disintegrating test, content uniformity test and in vitro dissolution test.

Background The pathophysiological changes following aneurysmal subarachnoid hemorrhage (aSAH) lead to a varied degree of neurological deficit and cognitive decline. The presence of comorbidities can contribute to the progression and course of the disease resulting in high morbidity and mortality. Methods A total of 140 patients with aSAH, scheduled for surgical clipping or endovascular coiling were included. The patients' comorbidities were recorded. The postoperative outcome was evaluated using Glasgow Outcome Scale at 1 month following discharge. Multiple logistic regression analysis was performed to identify variables predicting poor outcome, taking into consideration those variables which were significant in univariate analysis. Results Sixty-six percent of these patients with aSAH had associated comorbidities. In our patient cohort, we found that smoking and hypertension were associated with worse outcome (odds ratio [OR] = 4.63 [confidence interval [CI] = 1.83–11.7] and OR = 2.92 [CI = 1.41–6.01], respectively). Hypothyroidism, diabetes mellitus, coronary artery disease, and asthma did not influence the neurological outcome because of their small number. Conclusion Presence of comorbidities like smoking and hypertension significantly worsen the outcome of these patients with aSAH.

The increasing complexity of wound care in pediatric patients along with delay in the initiation of treatment predisposes these patients to many complications such as pressure ulcers, non-healing surgical wounds and skin damage. A retrospective study was conducted over a period of five years to gain insight into the etiology of pediatric wound infection. A total of 2819 wound culture positive cases were included. Most samples were from the burn ward (30.15%) followed by the general surgery ward (20.46%). Overall, the most common isolate was Staphylococcus aureus (39.73%) followed by Pseudomonas spp (19.12%). The prevalence of MRSA (Methicillin resistant S. aureus), CRE (Carbapenem-resistant Enterobacteriaceae), CRP (Carbapenem resistant Pseudomonas), CRAB (Carbapenem resistant Acinetobacter baumannii) was 47.3%, 62.5%, 70.5%, 96.4%, respectively. The high degree of resistance in children highlights the importance of regular surveillance for identification of common pathogens and optimization of antimicrobial treatment for multidrug resistant organisms.

Background: Chronic liver disease (CLD) is a condition of liver damage that includes cirrhosis and fibrosis of liver. It is a progressive destruction of liver functions due to inflammation, exertion of bile and detoxification of harmful products of metabolism. Objective : To assess the prescribing pattern in chronic liver disease patients and to facilitate rational use of medication. Method : A uni-centric prospective (observational) study was conducted for a period of 6 months for analyzing the prescribing pattern used in treating Chronic Liver Disease (CLD) patients. All the patients (both male and female) diagnosed with CLD visited to gastroenterology department were included in the study. Patients with pregnancy, age below 18 year and above 80 year were not involved in the study. Result: It was observed that the number of males accounted for the 64% of the total patients and rest 36% were females. CLD affected the age group of 48 – 58 years and the common causes were hepatitis C virus (55.55%) and alcohol consumption (26.19%).

Fortunately medical emergencies rarely occurs in daily dental practice. The risk of any serious complications can be reduced by ensuring that the basic life supporting drugs are in the appropriate place and the whole dental team should be well trained in basic life support measures. It is important for a dental practioner to have a thorough knowledge in recognizing and carrying out its initial management.

Approximately two-thirds of patients experience moderate to severe intensity pain following craniotomy. It is often undertreated due to fear of unfavorable side effects of commonly used analgesic drugs. The objectives of this review are to discuss the various aspects of acute and chronic post-craniotomy pain including its incidence, pathophysiology, diagnostic criteria, preventive strategies, and management in adult patients. The data have been consolidated based on our literature search from 1978 to 2021 using various databases including Google Scholar, Medline, and PubMed Central. We conclude that one must act at the earliest using various treatment modalities for post-craniotomy pain management.

Hypertonic saline (HTS) is a group of fluids containing sodium and chloride in a higher concentration as compared to physiological saline. The authors have conducted this review to evaluate the use of HTS in neuroanesthesia and neurocritical care. The articles for this narrative review on HTS were searched on databases like PubMed Central, EMBASE, and Google Scholar using the Medical Subject Headings keywords “Hypertonic Saline,” “Neuroanesthesia,” and “Neurocritical Care.” The review focuses on the mechanisms of HTS and its in routine clinical practice. The results of various comparative studies between HTS and mannitol and guidelines regarding the use of HTS have also been reviewed. HTS can be used to treat hyponatremia, reduce intracranial pressure, provide intraoperative relaxed brain, and aid in resuscitation during cardiogenic, neurogenic, and septic shock. Its side effects include renal toxicity in the case of hypernatremia, rebound intracranial hypertension, volume overload, dyselectrolytemia, phlebitis, local tissue damage, and osmotic demyelination syndrome in the case of rapid correction of serum sodium concentration.

Exosomes are secret intercellular messengers in the body, carrying crucial information from different organs. Different cargos can be packaged in exosomes including DNA, RNA, and proteins. The type of exosomal cargo can vary according to the tissue type, its pathophysiological state, and circadian rhythm. Therefore, exosomes have an immense potential to be utilized for diagnostic purposes if the conundrum of their cargo can be understood. Recent advances in exosome isolation and characterization have made it possible to define disease-specific cargo carried by these tiny messengers. We attempt to highlight disease-relevant exosomal cargos for diagnostic purposes.

Background: A worldwide outbreak of respiratory illnesses has been caused by coronavirus disease (COVID-19). Traditional healers have used herbs and dietary plants for centuries to treat various conditions. This review discusses the prevention of COVID-19, multiple herbs used in the treatment of COVID-19, and their future perspectives. Methodology: Various databases, such as PubMed, Web of Science, Scopus, Medline, and Google Scholar, were searched for articles related to herbal products' antiviral effects using different keywords: herbal, SARS-CoV-2, plant-derived drugs, COVID-19, coronavirus, etc. Results: Herbal treatment has been used as a contemporary alternative medicine for COVID-19. By inhibiting the replication and entry of SARS-CoV-2 into host cells, herbs can inhibit the pathogenesis of COVID-19. Conclusion: This article discusses COVID-19 infection, its salient features, spread, the life cycle of coronavirus, active response to coronavirus, proposed treatment, and herbal drugs used in the prevention and treatment of COVID-19.

Thrips are major pests of agricultural and horticultural crops worldwide. In addition to causing direct damage, thrips are the most common vector of tospoviruses. Currently, thrips control is mostly based on chemical insecticides, but effective control can be difficult to achieve because it has developed resistance to various insecticides. Therefore, there is an urgent need for novel alternative management options. A viable strategy for the management of the virus-vector complex involves understanding the molecular links between thrips and viruses and disrupting their association. RNA interference, a sequence-specific method to suppress target gene expression, is a conserved process in all eukaryotic organisms and has emerged as a new tool for reverse genetics and potential pest control. Advancements in RNA interference-based gene silencing techniques in the past few years could potentially be utilized in the management of the thrips-tospovirus complexes. RNA interference-mediated plant protection strategies have the potential to revolutionize pest management practices in a sustainable and effective way if development is carried out profoundly by discerning bioinformatics identification, in-silico designing of RNAi trigger molecules, laboratory and field-based toxicity and biosafety investigations.

Abstract: Wastage of food is a big concern for the world. In summers, several fruits are available like watermelon, muskmelon, etc. Muskmelons are fruits that are consumed all over the world. Around 32 % of muskmelon is wasted; it includes 5 % seeds and 27 % peel of the total weight. Seeds of muskmelons have great nutritional benefits. They have a very large number of bioactive compounds like tocopherols, phospholipids, and sterols. Muskmelon seeds have antimicrobial, anti-inflammatory, antioxidant, antidiabetic, anti-Alzheimer, and diuretic properties and can be used to treat or prevent many diseases. Therefore, muskmelon seeds can be used as a functional food.

Abstract: Enzymes are proteins and bio-catalysts. They are responsible for initiating a specific response to a specific outcome. In the dairy industry, numerous enzymes are used, such as rennet and proteolytic enzymes. These enzymes are used for the coagulation and ripening of cheese. Enzymes are also used to increase the nutritional value of dairy products to alleviate the state of malnutrition. This review paper converges on the utilization of different enzymes in the dairy processing industry.

Users often post on content-sharing platforms in the hope of attracting high engagement from viewers. Some posts receive unusual attention and go "viral", eliciting a significant response (likes, views, shares) to the creator in the form of popularity shocks. Past theories have suggested a sense of reputation as one of the key drivers of online activity and the tendency of users to repeat fruitful behaviors. Based on these, we theorize popularity shocks to be linked with changes in the behavior of users. In this paper, we propose a framework to study the changes in user activity in terms of frequency of posting and content posted around popularity shocks. Further, given the sudden nature of their occurrence, we look into the survival durations of effects associated with these shocks. We observe that popularity shocks lead to an increase in the posting frequency of users, and users alter their content to match with the one which resulted in the shock. Also, it is found that shocks are tough to maintain, with effects fading within a few days for most users. High response from viewers and diversification of content posted is found to be linked with longer survival durations of the shock effects. We believe our work fills the gap related to observing users' online behavior exposed to sudden popularity and has widespread implications for platforms, users, and brands involved in marketing on such platforms.

Polyhydroxybutyrate (PHB) is a biodegradable polymer accumulated as carbon and energy reserve granules by several bacteria and is ideal substitute for petroleum-based polymers. The present study aimed to isolate PHB producing bacteria and optimize medium components and growth conditions to enhance PHB yield. Potent PHB accumulating bacterial strain was isolated from oil spilled soil and identified as Bacillus endophyticus based on its 16S rRNA analysis. Sudan Black B staining method was used to detect PHB granules and affirmed by using Fourier Transform Infrared Spectroscopy. Differential scanning calorimetry analysis was conducted for thermal analysis of extracted PHB polymer. Bacillus endophyticus showed highest PHB accumulation utilizing glucose as the carbon and potassium nitrate as the nitrogen source which were further optimized along with physical parameters like pH and temperature using Box and Behnken method. The highest biomass (7.49 g/L) and PHB (3.67 g/L) were observed at pH 7, temp. 37ºC, glucose 25 g/L and potassium nitrate 0.1 g/L. Bacillus endophyticus was found to accumulate up to 49% PHB under optimized conditions. These results indicate the potential application of Bacillus endophyticus at the industrial level for PHB production.