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Your search keyword '"Janaína M. Santos"' showing total 2 results
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2 results on '"Janaína M. Santos"'

1. Effect of

Author

Janaína M, Santos, Nathalia M, Cury, José A, Yunes, Jorge A, López, and Maria L, Hernández-Macedo

Subjects
Plant Leaves, Phenols, Caspase 3, Plant Extracts, Cell Line, Tumor, Cell Cycle, Humans, Anacardium, Apoptosis, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Antineoplastic Agents, Phytogenic
Published
2018

2. Effect of Anacardium occidentale leaf extract on human acute lymphoblastic leukaemia cell lines

Author

Nathalia Moreno Cury, José Andrés Yunes, Janaína M. Santos, Maria Lucila Hernández-Macedo, and Jorge Lopez

Subjects
Folk medicine, Traditional medicine, 010405 organic chemistry, Anacardium, Organic Chemistry, Plant Science, Biology, biology.organism_classification, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, Cell culture, Polyphenol, Apoptosis, Lymphoblastic leukaemia
Abstract

Anacardium occidentale leaves are used in folk medicine due its therapeutic properties attributed to phenolic compounds. Therefore, this study was undertaken on its hydroethanolic leaf extract (AoHE) to evaluate cytotoxicity and apoptosis induction on acute lymphoblastic leukaemia cells. Results indicated that AoHE interfered in the cell cycle progression, inducing apoptosis by activation of casp3 at lower concentrations, thence, a promising candidate for the development of new cancer drugs.

Published
2018
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