Search

Additional file 1: Table S1. Causes of death in the 17 patients who died in the first 30-days after randomization. Table S2. Receiver-Operating-Curve Analysis for serum albumin to predict survival. Area-under-curve=0.75, p=0.01. Figure Supplementary 1. Kaplan-meier survival curves showing time-to-event curves of oral ulcer recovery in the two groups. (log-rank test p =0.40, median estimate to mucositis recovery in days was 4, 5 days). Figure Supplementary 2. Kaplan-Meier survival curves showing time-to-event curves of WBC recovery (≥4 x 10^9/L) in the two groups. (log-rank test p =0.07, median estimate to WBC recovery in days was 4, 6 days). Figure Supplementary 3. Kaplan-meier survival curves showing time-to-event curves of partial platelet recovery (≥50 x 10^9/L) in the two groups.(log-rank test p =0.86, median estimate in days to platelet recovery in leucovorin 15 and 25 mg groups was 4, 4 days). Figure Supplementary 4. Kaplan-meier survival curves showing time-to-event curves of both WBC (≥4 x 10^9/L) and platelet recovery (≥50 x 10^9/L) in the two groups. (Log-rank test p=0.50, Median estimate in days in leucovorin 15 and 25 mg groups to both EBC and partial platelet recovery was 5, 6 days). Figure S5. Methotrexate polyglutamate 1-3 levels determined by HPLC.

Predictions are made for the jet substructure of one-jet events produced in electron-proton neutral current deep inelastic scattering at the future Electron-Ion Collider for exchanged four-momentum squared, $Q^2 > 125$ GeV$^2$. Data are simulated using Monte Carlo event generators PYTHIA 8.304 and RAPGAP 3.308 at the center of mass energies $\sqrt{s}$ = 63.2, 104.9 and 141 GeV. Jets and subjets are produced by longitudinally invariant $k_T$ cluster algorithm. The subjet multiplicity distributions and differential jet shapes are measured for different jet sizes and varying jet-resolution parameter. A comparison is presented between the $k_T$ and anti-$k_T$ cluster algorithms for the study of jets and subjets using the simulated data and the HERA data., 11 pages, 15 figures

Vibration due to mass imbalance in rotating parts such as in pump impellers is an important engineering problem. It is a very important factor to be considered in modern machine design, especially where high speed and reliability are significant considerations. Due to mass imbalance excessive vibration occurs and may lead to decrease in fluid velocity and pressure which may cause cavitation in the pump. Reducing rotor vibrations generally increases the service life of the rotating machinery. International Standard ISO 1940/1 is a widely accepted reference for selecting rigid rotor balance quality. This paper presents effect of balancing a Boiler Feed Pump (BFP) on two different grades G6.3 and G2.5 as specified by ISO 1940/1 and their effect on the pump performance considering the vibration as the parameter. &nbsp

We demonstrate multiple bandgap integration on the hybrid silicon platform using quantum well intermixing. A broadband DFB laser array and a DFB-EAM array are realized on a single chip using four bandgaps defined by ion implantation enhanced disordering. The broadband laser array uses two bandgaps with 17 nm blue shift to compensate for gain roll-off while the integrated DFB-EAMs use the as-grown bandgap for optical gain and a 30 nm blue shifted bandgap for modulation. The multi-channel DFB array includes 13 lasers with >90 nm gain-bandwidth. The transponder includes four DFB-EAMs with 14 dB DC extinction at 4 V bias.

We have demonstrated a traveling-wave electroabsorption modulator based on the hybrid silicon platform. For a device with a 100 μm active segment, the small-signal electro/optical response renders a 3 dB bandwidth of around 42 GHz and its modulation efficiency reaches 23 GHz/V. A dynamic extinction ratio of 9.8 dB with a driving voltage swing of only 2 V was demonstrated at a transmission rate of 50 Gb/s. This represents a significant improvement for modulators compatible with integration of silicon-based photonic integrated circuits.