1. Outcome associated with prescription of cardiac rehabilitation according to predicted risk after acute myocardial infarction: Insights from the FAST-MI registries
- Author
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Debiec, Hanna, Dossier, Claire, Letouzé, Eric, Gillies, Christopher, Vivarelli, Marina, Putler, Rosemary, Ars, Elisabet, Jacqz-Aigrain, Evelyne, Elie, Valery, Colucci, Manuela, Debette, Stéphanie, Amouyel, Philippe, Elalaoui, Siham, Sefiani, Abdelaziz, Dubois, Valérie, Kretzler, Matthias, Ballarin, Jose, Emma, Francesco, Sampson, Matthew, Deschênes, Georges, Ronco, Pierre, Ederhy, Stephane, Cohen, Ariel, Boccara, Franck, Aissaoui, Nadia, Elbaz, Meyer, Bonnefoy-Cudraz, Eric, Druelles, Philipe, Andrieu, Stéphane, Angoulvant, Denis, Furber, Alain, Cottin, Yves, Puymirat, Etienne, Bonaca, Marc, Iliou, Marie-Christine, Tea, Victoria, Ducrocq, Grégory, Douard, Hervé, Labrunee, Marc, Plastaras, Philoktimon, Chevallereau, Pierre, Taldir, Guillaume, Bataille, Vincent, Ferrières, Jean, Schiele, François, Simon, Tabassome, Danchin, Nicolas, Centre de Ressources Biologiques APHP-SU (PASS-CRB-APHP-SU), Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé (PASS), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Male ,Time Factors ,MESH: Registries ,health care facilities, manpower, and services ,[SDV]Life Sciences [q-bio] ,medicine.medical_treatment ,Cardiac rehabilitation ,030204 cardiovascular system & hematology ,MESH: Risk Assessment ,MESH: Aged, 80 and over ,0302 clinical medicine ,Risk Factors ,MESH: Risk Factors ,Medicine ,Registries ,MESH: Cardiac Rehabilitation ,030212 general & internal medicine ,Myocardial infarction ,Atherothrombotic risk stratification ,Non-ST Elevated Myocardial Infarction ,health care economics and organizations ,Cancer ,MESH: Treatment Outcome ,Aged, 80 and over ,MESH: Aged ,education.field_of_study ,MESH: Middle Aged ,Framingham Risk Score ,Rehabilitation ,nephrotic syndrome ,MESH: Polymorphism, Single Nucleotide ,Hazard ratio ,Score ,genetic renal disease ,General Medicine ,Middle Aged ,MESH: Recovery of Function ,3. Good health ,In-hospital mortality ,Treatment Outcome ,Stratification risque athérothrombotique ,cardiovascular system ,Female ,France ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,pediatrics ,education ,Population ,Infarctus du myocarde ,Acute myocardial infarction ,Mortalité ,MESH: Phenotype ,Risk Assessment ,03 medical and health sciences ,Intensive care ,Internal medicine ,MESH: Spain ,Humans ,cardiovascular diseases ,Mortality ,Réadaptation cardiaque ,MESH: ST Elevation Myocardial Infarction ,Medical prescription ,Aged ,focal segmental glomerulosclerosis ,genome-wide association study ,MESH: Humans ,business.industry ,MESH: Time Factors ,MESH: Italy ,Recovery of Function ,medicine.disease ,MESH: Male ,MESH: Quantitative Trait Loci ,MESH: Steroids ,Confidence interval ,MESH: France ,MESH: Non-ST Elevated Myocardial Infarction ,gene expression ,Mortalité hospitalière ,ST Elevation Myocardial Infarction ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,MESH: Nephrotic Syndrome ,business ,MESH: Female - Abstract
Cardiac rehabilitation is strongly recommended in patients after acute myocardial infarction.To assess cardiac rehabilitation prescription after acute myocardial infarction according to predicted risk, and its association with 1-year mortality, using the FAST-MI registries.We used data from three 1-month French nationwide registries, conducted 5 years apart from 2005 to 2015, including 13130 patients with acute myocardial infarction admitted to coronary or intensive care units. Atherothrombotic risk stratification was performed using the Thrombolysis In Myocardial Infarction Risk Score for Secondary Prevention (TRS-2P). Patients were classified into three categories: Group 1 (low risk; no or one risk indicator; score of 0 or 1); Group 2 (intermediate risk; two risk indicators; score of 2); and Group 3 (high risk; at least three risk indicators; score of≥3).Among the 12291 patients, cardiac rehabilitation prescription was 43.6% (49.9% in Group 1; 43.0% in Group 2; 35.2% in Group 3). Using Cox multivariable analysis, cardiac rehabilitation prescription was associated with lower mortality at 1 year in the overall population (3.8% vs. 8.2%; hazard ratio [HR] 0.72, 95% confidence interval [CI] 0.61-0.85; P0.001). Cardiac rehabilitation was associated with improved 1-year mortality, with homogeneous relative risk reductions in low- and intermediate-risk categories (HR 0.70, 95% CI 0.51-0.94) compared with high-risk patients (HR 0.72, 95% CI 0.59-0.88). In absolute terms, however, mortality decrease associated with cardiac rehabilitation was positively correlated with risk level (Group 1, 0.9% vs. 2.4%; Group 2, 3.0% vs. 4.2%; Group 3, 10.5% vs. 17.3%).Cardiac rehabilitation prescription was inversely correlated with patient risk. A positive association between cardiac rehabilitation and 1-year survival after acute myocardial infarction was present whatever the risk level, but the greatest mortality reduction was observed in high-risk patients.
- Published
- 2019