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In a human case of Creutzfeldt-Jakob disease, fragments of membranes were seen within some vacuoles. They form accumulations of vesicular or curled structures and have to be differentiated from other membranous profiles that one can observe within the large spongy cavities.

The electron microscopic study of a cortical biopsy from a child presenting a Tuberous Sclerosis shows the importance of the astrocytic gliosis, the existence of abnormal cells of which two types can be recognized, and the presence of giant cells. All these cells are remarkable by the abundance of the ergastoplasm, the development of the Golgi apparatus, and the presence of membrane bound dense bodies. These cells are undoubtedly of astrocytic origin and appear very similar to the cells observed in a tumour of the caudate nucleus of another child affected by the same disease.