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Background. Hirschsprung’s disease (HD) is one of the most common motility disorders in pediatric age groups and it is very important that it be differentiated from other types of motility disorders, especially intestinal neuronal dysplasia B (IND B). Although many studies regarding the differences between the two disorders by immunohistochemical studies exist, there is as yet no consistent result. The purpose of this research was to study the immunohistochemical findings of enteric nervous system in these two motility disorders in comparison with colectomies without motility disorder. Methods. Full wall thickness specimens of three groups of patients (HD, IND B and non motility disorders) were included in the study to be evaluated by immunohistochemistry (IHC). Markers were specific for neuronal cells and pace maker cells composed of PGP 9.5, c-kit, synaptophysin, S100 and CD56. The number of cells was evaluated in the muscularis properia, and myenteric plexus. Results. The number of all the IHC markers i.e. PGP9.5, c-kit, synaptophysin, S100 and CD56 was completely different in HD from the two other groups, while IND B was quite similar to control group. Conclusion. Our finding suggests that there is a marked and significant difference between HD and IND B by IHC markers, which can be used as an additional test for the diagnosis of HD with more accuracy. Further multicenter studies with a greater number of cases would be necessary to find a cut-off point for every IHC marker to differentiate HD and IND B.

Background: High psychiatric disorders frequency, especially mood disorders, among patients with skin diseases has been proved. Skin diseases can reduce the self-esteem and more suicidal thought and commitment have been reported among these patients. The aim of this study was to evaluate the psychological profile of patients with skin diseases. Methods: In this cross-sectional study, 250 patients with skin lesions aged from 16 to 60 years were submitted to survey by random convenience sampling. General health questionnaire-28 (GHQ-28) and Hospital anxiety depression scale (HADS) were used for measuring psychological profile. Data were analyzed using Mann-Whitney, chi-square, independent-t, Kruskal-Wallis and Spearman correlation tests. Findings: Psychiatric disorders prevalence, based on GHQ-28, was 60%. Social function disorder, anxiety and insomnia, somatic symptoms and depression had the higher average rank and frequency, respectively. HADS screening showed 27.6% of prevalence for psychological profile problems and 27.87% for anxiety and depression subscales. Sex and age had no significant correlation to the psychological profile of patients. On the other hand, the marriage status and body location of skin lesions were statistically correlated to psychological profile. Conclusion: This study confirms the correlation between impaired psychological profile and skin lesions. With regards to high amount of outpatient refer to dermatology clinics, psychological consideration of dermatologic outpatients for preventive and probable therapeutic measurements is recommended.