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1. Quality of bowel cleansing in hospitalized patients undergoing colonoscopy: A multicentre prospective regional study

Author

Rotondano, G, Rispo, A, Bottiglieri, Me, De, Luca, L, Lamanda, R, Orsini, L, BRUZZESE, EUGENIA, GALLORO, GIUSEPPE, Romano, M, Miranda, A, Loguercio, C, Esposito, P, NARDONE, GERARDO ANTONIO PIO, COMPARE, DEBORA, Magno, L, Ruggiero, S, Imperatore, N, De, Palma, Gennarelli, N, Cuomo, R, Passananti, V, Cirillo, M, Cattaneo, D, Bozzi, Rm, D'Angelo, V, Marone, P, Riccio, E, DE NUCCI, GERMANA, C, Monastra, S, CARAVELLI, ANTONELLA, Verde, C, Di, Giorgio, P, Giannattasio, F, Capece, G, Taranto, D, De, Seta, M, Spinosa, G, De, Stefano, S, Familiari, V, Cipolletta, L, Bianco, Ma, Sansone, S, Galasso, G, DE COLIBUS, PATRIZIA, Borgheresi, P, Ricco, Antonio, Martorano, M, Gravina, Ag, Marmo, R, Rea, M, Maurano, A, Labianca, O, Colantuoni, E, Iuliano, D, Trovato, C, Fontana, A, Pasquale, L, Morante, A, Perugini, B, Scaglione, G, Mauro, B., BRUZZESE DARIO, Rotondano, G, Rispo, A, Bottiglieri, Me, De, Luca, L, Lamanda, R, Orsini, L, Bruzzese, Eugenia, Galloro, Giuseppe, Romano, M, Miranda, A, Loguercio, C, Esposito, P, Nardone, GERARDO ANTONIO PIO, Compare, Debora, Magno, L, Ruggiero, S, Imperatore, N, De, Palma, Gd, Gennarelli, N, Cuomo, R, Passananti, V, Cirillo, M, Cattaneo, D, Bozzi, Rm, D'Angelo, V, Marone, P, Riccio, E, DE NUCCI, Germana, Monastra, S, Caravelli, Antonella, Verde, C, Di, Giorgio, P, Giannattasio, F, Capece, G, Taranto, D, De, Seta, M, Spinosa, G, De, Stefano, S, Familiari, V, Cipolletta, L, Bianco, Ma, Sansone, S, Galasso, G, DE COLIBUS, Patrizia, Borgheresi, P, Ricco, Antonio, Martorano, M, Gravina, Ag, Marmo, R, Rea, M, Maurano, A, Labianca, O, Colantuoni, E, Iuliano, D, Trovato, C, Fontana, A, Pasquale, L, Morante, A, Perugini, B, Scaglione, G, Mauro, B., Bruzzese, Dario, De Luca, L, Bruzzese, D, Galloro, G, SIED Campania PISCoPO study group, Investigator, Romano, Marco, Loguercio, Carmelina, Nardone, G, Compare, D, De Palma, Gd, De Nucci, C, Caravelli, G, Di Giorgio, P, De Seta, M, De Stefano, S, De Colibus, P, Ricco, G, and Scaglione, G.

Subjects
Male, Multivariate analysis, Hospitalized patients, Colonoscopy, Sex Factor, Gastroenterology, Body Mass Index, Cardiovascular Disease, Outpatients, Prospective Studies, Aged, 80 and over, Chronic constipation, education.field_of_study, medicine.diagnostic_test, Cathartics, Cathartic, Outpatient, Diabetes Mellitu, Middle Aged, Cardiovascular Diseases, Cleansing, Female, Inpatient, Human, Adult, medicine.medical_specialty, Population, Sex Factors, Bowel preparation, Internal medicine, Diabetes mellitus, Preoperative Care, Diabetes Mellitus, medicine, Humans, education, Aged, Inpatients, Hepatology, business.industry, Odds ratio, Hospitalized patient, medicine.disease, Endoscopy, Prospective Studie, Chronic Disease, business, Constipation
Abstract

Background Quality of bowel cleansing in hospitalized patients undergoing colonoscopy is often unsatisfactory. No study has investigated the inpatient or outpatient setting as cause of inadequate cleansing. Aims To assess degree of bowel cleansing in inpatients and outpatients and to identify possible predictors of poor bowel preparation in the two populations. Methods Prospective multicentre study on consecutive colonoscopies in 25 regional endoscopy units. Univariate and multivariate analysis with odds ratio estimation were performed. Results Data from 3276 colonoscopies were analyzed (2178 outpatients, 1098 inpatients). Incomplete colonoscopy due to inadequate cleansing was recorded in 369 patients (11.2%). There was no significant difference in bowel cleansing rates between in- and outpatients in both colonic segments. In the overall population, independent predictors of inadequate cleansing both at the level of right and left colon were: male gender (odds ratio, 1.20 [1.02–1.43] and 1.27 [1.05–1.53]), diabetes mellitus (odds ratio, 2.35 [1.68–3.29] and 2.12 [1.47–3.05]), chronic constipation (odds ratio, 1.60 [1.30–1.97] and 1.55 [1.23–1.94]), incomplete purge intake (odds ratio, 2.36 [1.90–2.94] and 2.11 [1.68–2.65]) and a runway time >12 h (odds ratio, 3.36 [2.40–4.72] and 2.53 [1.74–3.67]). Conclusions We found no difference in the rate of inadequate bowel preparation between hospitalized patients and outpatients.

Published
2015
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4. Long-term liver histology improvement in patients with chronic hepatitis C and sustained response to interferon

Author

Toccaceli, F, Laghi, V, Capurso, L, Koch, M, Sereno, S, Scuderi, M, Stellini, R, Cristini, G, Zammataro, M, Russello, M, Pizzigallo, E, Vecchiet, J, Guaglianone, L, Vigna, L, Frugiuele, Pl, Milani, S, Pignalosa, P, De Conca, V, Mesiti, S, Castellacci, R, Mignani, El, Artioli, Sl, De Luca Andrioli, E, Maci, Am, Ascione, A, De Luca, M, Persico, M, Palmentieri, B, Esposito, P, Iuliano, D, Tarantino, G, Conca, P, Scolastico, C, Stanzione, M, Colletta, C, Montalto, G, Vuturo, O, Tripi, S, Alessandri, A, Sabatella, C, De Stefano, G, Ceglia, T, Fornaciari, G, Castagnetti, E, Barlattani, A, Veglio, V, Bonasso, M, Starnini, G, Scotto, G, Toccaceli, Fabrizio, Laghi, V., Capurso, Mauro, Koch, M., Sereno, S., Scuderi, M., Stellini, R., Cristini, G., Zammataro, M., Russello, M., Pizzigallo, E., Vecchiet, J., Guaglianone, L., Vigna, L., Frugiuele, P. L., Milani, S., Pignalosa, P., De Conca, V., Mesiti, S., Castellacci, R., Mignani, E., Artioli, S., De Luca Andrioli, E. P., Maci, A. M., Ascione, A., De Luca, M., Persico, M., Palmentieri, B., Esposito, P., Iuliano, D., Tarantino, Giovanni, Conca, P., Scolastico, C., Stanzione, M., Colletta, C., Montalto, G., Vuturo, O., Tripi, S., Alessandri, A., Sabatella, C., De Stefano, G., Ceglia, T., Fornaciari, G., Castagnetti, E., Barlattani, A., Veglio, V., Bonasso, M., Starnini, G., and Scotto, G.

Subjects
Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Pathology, Hepacivirus, Biopsy, Alpha interferon, Infectious Disease, Chronic hepatitis C, Gastroenterology, Statistics, Nonparametric, Fibrosis, Recurrence, Virology, Internal medicine, medicine, Humans, Multicenter Studies as Topic, Aged, Retrospective Studies, Hepatology, medicine.diagnostic_test, biology, business.industry, Interferon-alpha, Retrospective cohort study, Alanine Transaminase, Hepatitis C, Liver biopsy, Hepatitis C, Chronic, Middle Aged, biology.organism_classification, medicine.disease, Infectious Diseases, Alanine transaminase, HCV, biology.protein, Interferon, RNA, Viral, Female, business, chronic hepatitis c, hcv, interferon, liver biopsy
Abstract

A retrospective multicentre survey was conducted to evaluate, in patients with chronic hepatitis C, the long-term liver histological changes induced by interferon (IFN). A total of 112 patients (mean age 46.4 years) were studied. All patients had received a 6-12-month IFN-alpha course (6-18 MU/week) and had successively undergone clinical, biochemical and virological follow-up for at least 36 months (range: 36-76). In each patient, two liver biopsies had been performed: 1-6 months before treatment and, 12-76 months after its completion. In 87 patients with biochemical and virological sustained response persisting for 12 months after therapy, post-treatment liver necroinflammation and fibrosis mean(+/-SD) scores (Knodell index) were significantly lower than pretreatment scores (2.9 +/- 2.2 vs 6.8 +/- 2.9 and 0.8 +/- 1.0 vs 1.2 +/- 1.1, respectively; P0.01). In 25 patients who relapsed within 1 year, necroinflammation and fibrosis post-treatment mean scores were similar to pretreatment scores (7.4 +/- 3.2 vs 6.9 +/- 3.1 and 1.8 +/- 1.3 vs 1.6 +/- 1.2, respectively; P0.05). On an individual basis, necroinflammation decreased in 87% of sustained responders but only in 36% of relapsers (P0.001), whereas fibrosis decreased in 44% of sustained responders but only in 14% of relapsers (P0.001). In sustained responders with biopsies performed 12-23 months (n=34), 24-35 months (n=26) or more than 36 months (n=27) after treatment, a progressive decrease of mean necroinflammatory score was observed (-2.6 +/- 2.1, -4.1 +/- 3.4 and -5.2 +/- 3.7 points, respectively; P0.01). A similar pattern was observed in fibrosis score (-0.3 +/- 0.6, -0.3 +/- 0.7 and -0.7 +/- 0.9 points, respectively; P0.05). Hence, among chronic hepatitis C patients treated with IFN, those with a 12-month sustained response, unlike those who relapse, have a long-term progressive reduction and, in some cases, a complete regression of liver histological damage.

Published
2003

5. An hybrid simulation model to support decision making in a manufacturing plant

Author

Elpidio Romano, Cesarano, C., Iuliano, D., Romano, Elpidio, C., Cesarano, and D., Iuliano

Subjects
decision suport system, Modeling and Simulation, System Dynamics Simulation
Abstract

The objective of the following paper is to determine a quantitative approach is generic enough and able to reproduce the logical steps for the construction of tools for decision support systems. The heart of the problem is the use of simulation techniques based on the concepts of System Dynamics. A further innovation is logged in the System Dynamics is to demonstrate how an efficient technique used in decision support systems, not only strategic, but also tactics. The paper will consist of five sections. First we will describe the main characteristics of the DSS and their role in decision-making. In the second section we focus will shift on the simulation, in particular, we highlight the differences between the various techniques and its role within the DSS . In the last few three sections it will be a case study, which will be exposed, as we were able to solve a problem using the System Dynamics. In particular, there will be an in-depth analysis of the problem. In the fourth will turn to an analysis of data and the description of the simulation model. Finally, in the fifth and final section, we discuss how the simulation was carried out and the results thereof, the latter will be analyzed and be put forward ideas for resolving the problem, the simulation will be performed again and will report the results of various scenarios.

6. Re-treatment of patients with chronic hepatitis C in clinical practice: Results of a multicenter retrospective survey,Ritrattamento dei pazienti con epatite cronica da HCV nella pratica clinica: Risultati di uno studio multicentrico retrospettivo

Author

Pizzigallo, E., Toccaceli, F., Vecchiet, J., Di Girolamo, A., Sereno, S., Koch, M., Capurso, L., Lagiii, V., Laghi, V., Santoro, L., Servillo, F., Brillanti, S., Stellini, R., Allegri, R., Filippis, V., Arbore, S., Zammataro, M., Russello, M., Santis, S., Martino, G., Frugiuele, P. L., Spagnuolo, V., Milani, S., Pignalosa, P., Vinelli, F., Cela, E. M., Conca, V., Mesiti, S., Castellacci, R., Mignani, E., Artioli, S., Luca Andrioli, E. P., Maci, A. M., Luca, M., Picciotto, F. P., Marcello Persico, Palmentieri, B., Esposito, P., Iuliano, D., Tarantino, G., Conca, P., Piccinino, F., Scolastico, C., Colletta, C., Montalto, G., Vuturo, O., Tripi, S., Bonfissuto, G., Petrelli, E., Stoppini, L., Marenco, G., Azzola, E., Sabatella, C., Stefano, G., Ceglia, T., Fornaciari, G., Castagnetti, E., Armignacco, O., Barlattani, A., Veglio, V., Bonasso, M., Araneo, A., Carretta, V., Bertuccio, S., Brogna, M., Starnini, G., Foresti, F., and Scaduti, S.

7. Re-treatment of patients with chronic hepatitis C in clinical practice: Results of a multicenter retrospective survey | Ritrattamento dei pazienti con epatite cronica da HCV nella pratica clinica: Risultati di uno studio multicentrico retrospettivo

Author

Pizzigallo, E., Toccaceli, F., Vecchiet, J., Di Girolamo, A., Sereno, S., Koch, M., Capurso, L., Lagiii, V., Laghi, V., Santoro, L., Servillo, F., Brillanti, S., Stellini, R., Allegri, R., Filippis, V., Arbore, S., Zammataro, M., Russello, M., Santis, S., Martino, G., Frugiuele, P. L., Spagnuolo, V., Milani, S., Pignalosa, P., Vinelli, F., Cela, E. M., Conca, V., Mesiti, S., Castellacci, R., Mignani, E., Artioli, S., Luca Andrioli, E. P., Maci, A. M., Luca, M., Picciotto, F. P., Persico, M., Palmentieri, B., Esposito, P., Iuliano, D., Tarantino, G., Conca, P., Piccinino, F., Scolastico, C., Colletta, C., Giuseppe MONTALTO, Vuturo, O., Tripi, S., Bonfissuto, G., Petrelli, E., Stoppini, L., Marenco, G., Azzola, E., Sabatella, C., Stefano, G., Ceglia, T., Fornaciari, G., Castagnetti, E., Armignacco, O., Barlattani, A., Veglio, V., Bonasso, M., Araneo, A., Carretta, V., Bertuccio, S., Brogna, M., Starnini, G., Foresti, F., and Scaduti, S.

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