18 results on '"Irène Gallais Sérézal"'
Search Results
2. Treatment of dissecting cellulitis of the scalp with tumour necrosis factor inhibitors: a retrospective multicentre study
- Author
-
Muslih Alzahrani, Victor Coste, Maria Polina Konstantinou, Ziad Reguiai, Axel Villani, Claire Hotz, Manuelle Viguier, Christelle Pruvost-Balland, Alain Dupuy, Pierre Wolkenstein, Aurore Brun, François Aubin, and Irène Gallais Sérézal
- Subjects
Dermatology - Abstract
Although retinoids are considered as the most effective treatment, management of dissecting cellulitis of the scalp (DCS) is often challenging. A multicentre retrospective study was conducted to evaluate the efficacy of anti-tumour necrosis factor (TNF) agents in treating DCS after failure of other conventional treatments. Twenty-six patients were included. After a mean treatment duration of 19 months (SD 21), the median Physician’s Global Assessment score decreased from 3 to 1. The median number of inflammatory nodules and abscesses decreased from 7 to 0.5 and from 1 to 0, respectively. The median Dermatology Life Quality Index and numerical rating scale score for pain severity decreased from 10 to 8 and 6 to 1, respectively. The median treatment satisfaction was 7 out of 10 on the Patient Satisfaction Index. This study confirms the efficacy of anti-TNF agents in treating patients with DCS that is resistant to conventional therapies.
- Published
- 2023
3. T cells in resolved allergic contact dermatitis steer tissue inflammation and MMP-12-driven tissue modulation
- Author
-
Irène Gallais Sérézal, Poojabahen Tajpara, Trine Schonfeldt, Borislav Ignatov, Daniel Sortebech, Elena Hoffer, Tianqi Zhang, Elin Rooijackers, Marcus Ehrström, Susanne Nylén, Míhaly Matura, Keira Melican, and Liv Eidsmo
- Subjects
Inflammation ,Matrix Metalloproteinase 12 ,Immunology ,Dermatitis, Allergic Contact ,Immunology and Allergy ,Humans - Published
- 2022
4. The cardiometabolic conditions of psoriatic disease
- Author
-
Eric Toussirot, Irène Gallais-Sérézal, and François Aubin
- Subjects
Inflammation ,Methotrexate ,Cardiovascular Diseases ,Tumor Necrosis Factor-alpha ,Immunology ,Arthritis, Psoriatic ,Interleukin-17 ,Immunology and Allergy ,Cytokines ,Humans ,Psoriasis ,Interleukin-23 - Abstract
Psoriasis (PsO) and psoriatic arthritis (PsA), together known as psoriatic disease (PsD), are immune-mediated diseases with a chronic and relapsing course that affect the skin, the joints or both. The pathophysiology of PsO is complex and involves abnormal expression of keratinocytes and infiltration of the skin with dendritic cells, macrophages, neutrophils and T lymphocytes. Around 30% of patients with PsO develop arthritis with axial and/or peripheral manifestations. Both PsO and PsA share similar Th1- and Th17-driven inflammation, with increased production of inflammatory cytokines, including TNFα, IFN-γ, IL-17, IL-22, IL-23 in the skin and the synovial membrane. PsD is associated with a high burden of cardiometabolic diseases such as hypertension, diabetes, dyslipidemia, obesity, metabolic syndrome and cardiovascular (CV) complications as compared to the general population. These comorbidities share common immunopathogenic pathways linked to systemic inflammation, and are associated with the extent and severity of the disease. Morever, they can influence treatment outcomes in PsD. In this short review, we summarize the available evidence on the epidemiology, clinical aspects and mechanisms of cardiometabolic conditions in patients with PsD. We also discuss the impact of targeted treatments such as methotrexate and biological agents on these cardiometabolic conditions.
- Published
- 2022
5. miR-19a/b and miR-20a Promote Wound Healing by Regulating the Inflammatory Response of Keratinocytes
- Author
-
Xinling Bi, Sergiu-Bogdan Catrina, Changchun Xiao, Ola Rollman, Warangkana Lohcharoenkal, Xiaowei Zheng, Hongmei Peng, Queping Liu, Ning Xu Landén, Dongqing Li, Enikö Sonkoly, Le Qu, Li Zhou, Irène Gallais Sérézal, Aoxue Wang, Jacob Grünler, Xi Li, Mona Ståhle, Pehr Sommar, Tongbin Chu, Qing-Sheng Mi, Andor Pivarcsi, and Sofie Eliasson Angelstig
- Subjects
Keratinocytes ,Male ,0301 basic medicine ,Chemokine ,Cell- och molekylärbiologi ,Biochemistry ,Gene Knockout Techniques ,Mice ,0302 clinical medicine ,Conditional gene knockout ,Aged, 80 and over ,Mice, Knockout ,Pressure Ulcer ,Toll-like receptor ,integumentary system ,biology ,Middle Aged ,Diabetic Foot ,Healthy Volunteers ,Dermatology and Venereal Diseases ,Diabetic foot ulcer ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cytokines ,Female ,RNA, Long Noncoding ,medicine.symptom ,Keratinocyte ,Adult ,Adolescent ,Inflammation ,Dermatology ,Streptozocin ,Cell Line ,Diabetes Mellitus, Experimental ,03 medical and health sciences ,Downregulation and upregulation ,medicine ,Animals ,Humans ,Dermatologi och venereologi ,Molecular Biology ,Aged ,Wound Healing ,business.industry ,Immunology in the medical area ,Cell Biology ,medicine.disease ,Disease Models, Animal ,MicroRNAs ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,Gene Expression Regulation ,Immunologi inom det medicinska området ,Case-Control Studies ,biology.protein ,Cancer research ,business ,Wound healing ,Cell and Molecular Biology - Abstract
Persistent and impaired inflammation impedes tissue healing and is a characteristic of chronic wounds. A better understanding of the mechanisms controlling wound inflammation is needed. In this study, we show that in human wound-edge keratinocytes, the expressions of microRNA (miR)-17, miR-18a, miR-19a, miR-19b, and miR-20a, which all belong to the miR-17∼92 cluster, are upregulated during wound repair. However, their levels are lower in chronic ulcers than in acute wounds at the proliferative phase. Conditional knockout of miR-17∼92 in keratinocytes as well as injection of miR-19a/b and miR-20a antisense inhibitors into wound edges enhanced inflammation and delayed wound closure in mice. In contrast, conditional overexpression of the miR-17∼92 cluster or miR-19b alone in mice keratinocytes accelerated wound closure in vivo. Mechanistically, miR-19a/b and miR-20a decreased TLR3-mediated NF-κB activation by targeting SHCBP1 and SEMA7A, respectively, reducing the production of inflammatory chemokines and cytokines by keratinocytes. Thus, miR-19a/b and miR-20a being crucial regulators of wound inflammation, the lack thereof may contribute to sustained inflammation and impaired healing in chronic wounds. In line with this, we show that a combinatory treatment with miR-19b and miR-20a improved wound healing in a mouse model of type 2 diabetes.
- Published
- 2021
6. Caractérisation prospective du profil cytokinique lacrymal des patients présentant une dermatite atopique et traités par dupilumab
- Author
-
Irène Gallais Sérézal, François Aubin, Cécile Chagué, Louise Vuillemey, Eve Puzenat, Bernard Delbosc, Anne-Sophie Gauthier, and Camille Febvay
- Subjects
Ocean Engineering ,Safety, Risk, Reliability and Quality - Abstract
Introduction Le dupilumab est la premiere biotherapie disponible pour la dermatite atopique (DA). Il repose sur l’inhibition de l’IL-4 et de l’IL-13. Cette therapie peut entrainer des conjonctivites, dont l’incidence est evaluee a 5–28 % selon les etudes cliniques. Les mecanismes impliques dans la conjonctivite associee au dupilumab (CAD) ne sont pas elucides. Notre objectif etait d’etudier la faisabilite et de comparer les profils cytokiniques des larmes collectees de facon non invasive avant puis sous traitement par dupilumab, chez les patients avec et sans conjonctivite induite. Materiel et methodes Nous avons mene une etude prospective monocentrique de patients recevant du dupilumab pour une DA. Des echantillons lacrymaux etaient collectes par capillarite a l’initiation du traitement, puis a 4 mois et 8 mois apres l’instauration. Les patients ayant developpe une conjonctivite etaient suivis ensuite tous les deux mois. Une recherche de demodex sur les cils etait aussi effectuee a l’instauration. Les dosages d’IL-2, 4, 6, 10, 17A, d’IFNg et de TNFa etaient realises en cytometrie de flux. Une numeration et formule des leucocytes lacrymaux etait aussi effectuee. Resultats Vingt et un patients traites par dupilumab etaient inclus et 10 controles sains etaient aussi preleves pour comparaison. Cinq patients (24 %) ont developpe une conjonctivite induite, apres une moyenne de 2,3 mois. A l’instauration du dupilumab, le temps de rupture du film lacrymal au diagnostic etait plus court (6 secondes versus 4,5 s, NS) et le taux de lymphocytes lacrymaux etaient plus eleve chez les patients qui developpaient ensuite une conjonctivite. Les taux de cytokines lacrymales IL2, IL17A, IL10, IFNg semblaient plus eleves chez les patients qui ont ensuite developpe une CAD, mais non significatifs (p > 0,1), par rapport aux autres patients et temoins. L’IFNg, le TNF et l’IL-10 diminuaient sous traitement avec dupilumab (p Discussion Notre etude demontre la possibilite d’analyser de facon non invasive les cytokines dans les larmes de patients. Nos resultats preliminaires n’ont pas permis d’identifier de marqueur lacrymal significatif de CAD, probablement a cause d’un manque de puissance. Un taux eleve de lymphocytes et de polynucleaires eosinophiles au niveau lacrymal pourrait etre associe au developpement ulterieur d’une CAD.
- Published
- 2021
7. Iatrogenic recurrence of Kaposi sarcoma induced by the pharmacological interaction between periarticular injection of corticosteroids and ritonavir in a <scp>HIV</scp> ‐infected patient
- Author
-
Eve Puzenat, Laurent Hustache-Mathieu, Olivier Fakih, Christine Drobacheff-Thiebaut, François Aubin, and Irène Gallais Sérézal
- Subjects
medicine.medical_specialty ,business.industry ,Human immunodeficiency virus (HIV) ,Dermatology ,General Medicine ,medicine.disease ,medicine.disease_cause ,Gastroenterology ,Internal medicine ,Hiv infected ,medicine ,Ritonavir ,Sarcoma ,business ,Periarticular injection ,medicine.drug - Published
- 2020
8. Resident T Cells in Resolved Psoriasis Steer Tissue Responses that Stratify Clinical Outcome
- Author
-
Liv Eidsmo, Mauricio Barrientos-Somarribas, Ning Xu Landén, Susanne Nylén, Marcus Ehrström, Stanley Cheuk, Elisa Martini, Cajsa Classon, David Chang, Irène Gallais Sérézal, and Emma Wadman
- Subjects
Keratinocytes ,Male ,0301 basic medicine ,beta-Defensins ,Biopsy ,T cell ,Cell ,Human skin ,Dermatology ,Lymphocyte Activation ,Biochemistry ,Tissue Culture Techniques ,Transcriptome ,03 medical and health sciences ,Recurrence ,T-Lymphocyte Subsets ,Psoriasis ,Humans ,Medicine ,Molecular Biology ,Cells, Cultured ,Aged ,Skin ,integumentary system ,medicine.diagnostic_test ,biology ,Sequence Analysis, RNA ,business.industry ,Gene Expression Profiling ,Interleukin-17 ,Cell Biology ,Middle Aged ,medicine.disease ,Gene expression profiling ,Treatment Outcome ,030104 developmental biology ,medicine.anatomical_structure ,Immunology ,biology.protein ,Female ,Ultraviolet Therapy ,Antibody ,business ,Immunologic Memory ,Follow-Up Studies ,Muromonab-CD3 - Abstract
Psoriasis is driven by focal disruptions of the immune-homeostasis in human skin. Local relapse following cessation of therapy is common and unpredictable, which complicates clinical management of psoriasis. We have previously shown that pathogenic resident T cells accumulate in active and resolved psoriasis, but whether these cells drive psoriasiform tissue reactions is less clear. Here, we activated T cells within skin explants using the pan-T cell activating antibody OKT-3. To explore if T cells induced different tissue response patterns in healthy and psoriasis afflicted skin, transcriptomic analyses were performed with RNA-sequencing and Nanostring. Core tissue responses dominated by IFN-induced pathways were triggered regardless of the inflammatory status of the skin. In contrast, pathways induced by IL-17A, including Defensin beta 2 and keratinocyte differentiation markers, were activated in psoriasis samples. An integrated analysis of IL-17A and IFN-related responses revealed that IL-17 dominated tissue response correlated with early relapse following UVB treatment. Stratification of tissue responses to T cell activation in resolved lesions could potentially offer individualized prediction of disease relapse during long-term immunomodulatory treatment.
- Published
- 2018
9. A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis
- Author
-
Elena Hoffer, Liv Eidsmo, Borislav Ignatov, Elisa Martini, Marcus Ehrström, Irène Gallais Sérézal, and Beatrice Zitti
- Subjects
Keratinocytes ,Male ,0301 basic medicine ,Chemokine ,T-Lymphocytes ,Immunology ,Plasmacytoid dendritic cell ,C-C chemokine receptor type 6 ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Interferon ,Psoriasis ,medicine ,Humans ,Immunology and Allergy ,Skin ,integumentary system ,Epidermis (botany) ,biology ,business.industry ,medicine.disease ,Fungal antigen ,CCL20 ,030104 developmental biology ,biology.protein ,Female ,business ,medicine.drug - Abstract
Background Resident T cells are implicated in the maintenance and recurrence of psoriatic lesions. Whether skin that has not yet experienced psoriasis in patients with established disease harbors pathogenic T cells is less investigated. Objective We sought to analyze the composition of resident T cells and T cell–driven tissue responses in skin never affected by psoriasis from patients with mild disease. Methods Never-lesional skin from patients with psoriasis (NLP) was collected from those with mild disease. T-cell profiles were assessed by using confocal imaging and flow cytometry. Tissue responses to T-cell stimulation were measured by using multiplex and NanoString technology. Results T-cell activation ex vivo triggered psoriasiform and type I interferon tissue responses in NLP psoriasis. Accordingly, keratinocytes from NLP responded to IFN-γ stimulation with myxovirus 1 (MX1) expression and IFN-α release. Additionally, CCR6-expressing resident T cells poised to produce IFN-γ and IL-17 were enriched in epidermis from NLP, whereas dermal tissue responses and T-cell compositions were similar to those in healthy skin. Finally, keratinocytes from NLP exposed to IL-17 and skin explants exposed to common fungal antigens responded with upregulation of the CCR6 ligand CCL20. Conclusion Epidermal resident T cells capable of triggering psoriasiform tissue responses accumulate in epidermis from NLP. Our global analysis of NLP reveals that microbial interplay with genetically predisposed keratinocytes might shape the local pool of resident T cells.
- Published
- 2019
- Full Text
- View/download PDF
10. IL-22 binding protein regulates murine skin inflammation
- Author
-
Tomas Olsson, Pernilla Nikamo, André Ortlieb Guerreiro-Cacais, Liv Eidsmo, Elisa Martini, Mona Ståhle, Hannes Lindahl, Irène Gallais Sérézal, Maja Jagodic, and Susanna Brauner
- Subjects
Male ,0301 basic medicine ,Inflammation ,Imiquimod ,Dermatology ,Dermatitis, Contact ,Biochemistry ,Interleukin 22 ,Oxazolone ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Psoriasis ,medicine ,Animals ,Humans ,Aminoquinolines ,Molecular Biology ,business.industry ,Binding protein ,Receptors, Interleukin ,medicine.disease ,030104 developmental biology ,chemistry ,Case-Control Studies ,Immunology ,Female ,medicine.symptom ,business ,Contact dermatitis ,030215 immunology ,medicine.drug - Published
- 2017
11. MicroRNA-34 Family Enhances Wound Inflammation by Targeting LGR4
- Author
-
Dongqing Li, Xi Li, Eva K. Herter, Ning Xu Landén, Xiyun Ye, Jianmin Wu, Mengyao Qian, Anna-Maria Wintler, Mona Ståhle, Yijuan Li, Xiaolin Ren, Jakob D. Wikstrom, Ola Rollman, Maria-Alexandra Toma, and Irène Gallais Sérézal
- Subjects
Keratinocytes ,Male ,0301 basic medicine ,Chronic wound ,Chemokine ,Biopsy ,medicine.medical_treatment ,Biochemistry ,Receptors, G-Protein-Coupled ,Pathogenesis ,Mice ,0302 clinical medicine ,Cell Movement ,Medicine ,Phosphorylation ,Skin ,Aged, 80 and over ,Mice, Knockout ,integumentary system ,biology ,Middle Aged ,Healthy Volunteers ,Cytokine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,medicine.symptom ,Keratinocyte ,Signal Transduction ,Inflammation ,Dermatology ,Varicose Ulcer ,Proinflammatory cytokine ,03 medical and health sciences ,Animals ,Humans ,Molecular Biology ,Aged ,Cell Proliferation ,Wound Healing ,Glycogen Synthase Kinase 3 beta ,business.industry ,Transcription Factor RelA ,Cell Biology ,Disease Models, Animal ,MicroRNAs ,030104 developmental biology ,Gene Expression Regulation ,Cancer research ,biology.protein ,business ,Wound healing - Abstract
Venous ulcers are the most common type of human chronic nonhealing wounds and are stalled in a constant and excessive inflammatory state. The molecular mechanisms underlying the chronic wound inflammation remain elusive. Moreover, little is known about the role of regulatory RNAs, such as microRNAs, in the pathogenesis of venous ulcers. We found that both microRNA (miR)-34a and miR-34c were upregulated in the wound-edge epidermal keratinocytes of venous ulcers compared with normal wounds or the skin. In keratinocytes, miR-34a and miR-34c promoted inflammatory chemokine and cytokine production. In wounds of wild-type mice, miR-34a-mimic treatment enhanced inflammation and delayed healing. To further explore how miR-34 functions, LGR4 was identified as a direct target mediating the proinflammatory function of miR-34a and miR-34c. Interestingly, impaired wound closure with enhanced inflammation was also observed in Lgr4 knockout mice. Mechanistically, the miR-34-LGR4 axis regulated GSK-3β-induced p65 serine 468 phosphorylation, changing the activity of the NF-κB signaling pathway. Collectively, the miR-34-LGR4 axis was shown to regulate keratinocyte inflammatory response, the deregulation of which may play a pathological role in venous ulcers.
- Published
- 2020
12. Hereditary angioedema and lupus: A French retrospective study and literature review
- Author
-
Stéphane Gayet, Irène Gallais Sérézal, Laurence Bouillet, Robin Dhote, Arsène Mekinian, Olivier Fain, Pierre-Yves Jeandel, Claire Blanchard-Delaunay, and Ludovic Martin
- Subjects
medicine.medical_specialty ,Abdominal pain ,Immunology ,Complement C1 Inactivator Proteins ,Laryngeal Edema ,C1-inhibitor ,immune system diseases ,Humans ,Lupus Erythematosus, Systemic ,Immunology and Allergy ,Medicine ,skin and connective tissue diseases ,Danazol ,Systemic lupus erythematosus ,Angioedema ,biology ,business.industry ,Angioedemas, Hereditary ,Retrospective cohort study ,medicine.disease ,Dermatology ,Surgery ,Hereditary angioedema ,biology.protein ,Steroids ,France ,medicine.symptom ,business ,Complement C1 Inhibitor Protein ,medicine.drug - Abstract
Hereditary angioedema (HAE) is a rare genetic disorder that is primarily caused by a defect in the C1 inhibitor (C1-INH). The recurrent symptoms are subcutaneous edema and abdominal pain. Laryngeal edema, which can also occur, is life threatening if it goes untreated. HAE can be associated with some inflammatory and autoimmune disorders, particularly lupus. The aim of this study was to describe cases of lupus among HAE patients in France and to perform a literature review of lupus and HAE studies. Case detection and data collection (a standardized form) were performed, thanks to the French Reference Center for Kinin-related angioedema. Data were collected from 6 patients with type 1 HAE and lupus in France; no cases of systemic lupus erythematosus were reported. In the literature review, 32 cases of lupus combined with HAE were identified, including 26 female patients. The median patient age at the time of first reported HAE symptoms and at diagnosis were 17.5 years (range, 9-41 years) and 19 years (range, 9-64 years), respectively for our 6 patients and 14 years (range, 3-30 years) and 17 years (range, 7-48 years), respectively, for the literature review. The clinical manifestations of HAE were mainly abdominal pain (83% in our patients vs 47% in the literature) and edema of the limbs (83% vs 38%). The C4 levels were low (for 100% of our cases vs 93% in the literature). Eighteen patients in the literature demonstrated HAE symptoms prior to the lupus onset vs 5 for our patients. The mean patient age at lupus onset was 20 years (range, 13-76 years) for our patients and 19.5 years (range, 1-78 years) in the literature, respectively. In the literature, 81% of the patients had skin manifestations, 25% had renal involvement and 28% received systemic steroids to treat lupus. Treatment with danazol did not modify the clinical expression of lupus. The association between lupus and HAE is a rare but not unanticipated event. Patients are often symptomatic for HAE before developing lupus. Lupus cases associated with HAE share some characteristics of lupus cases related to other complement deficiencies, such as the absence of severity and the predominance of cutaneous symptoms.
- Published
- 2015
13. 633 Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration
- Author
-
Lara Kular, Dongqing Li, N. Xu Landén, Aoxue Wang, Maria-Alexandra Toma, David Berglund, Irène Gallais Sérézal, Lennart Blomqvist, Pehr Sommar, Maja Jagodic, L. Zhang, Magda Bienko, Manika Vij, Mona Ståhle, and Xi Li
- Subjects
Human skin ,Cell Biology ,Dermatology ,Biology ,Keratinocyte migration ,Wound healing ,Molecular Biology ,Biochemistry ,Long non-coding RNA ,Cell biology - Published
- 2019
14. CD49a Expression Defines Tissue-Resident CD8
- Author
-
Stanley, Cheuk, Heinrich, Schlums, Irène, Gallais Sérézal, Elisa, Martini, Samuel C, Chiang, Nicole, Marquardt, Anna, Gibbs, Ebba, Detlofsson, Andrea, Introini, Marianne, Forkel, Charlotte, Höög, Annelie, Tjernlund, Jakob, Michaëlsson, Lasse, Folkersen, Jenny, Mjösberg, Lennart, Blomqvist, Marcus, Ehrström, Mona, Ståhle, Yenan T, Bryceson, and Liv, Eidsmo
- Subjects
Cytotoxicity, Immunologic ,vitiligo ,Microscopy, Confocal ,Integrin alpha1 ,Cell Separation ,psoriasis ,CD8-Positive T-Lymphocytes ,Flow Cytometry ,Lymphocyte Activation ,CD49a ,Article ,IL-15 ,T-Lymphocyte Subsets ,granzyme B ,Humans ,cytotoxicity ,immunopathology ,Immunologic Memory ,tissue resident T cells ,perforin ,Skin - Abstract
Summary Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8+ Trm cells on a compartmental and functional basis. In human skin epithelia, CD8+CD49a+ Trm cells produced interferon-γ, whereas CD8+CD49a− Trm cells produced interleukin-17 (IL-17). In addition, CD8+CD49a+ Trm cells from healthy skin rapidly induced the expression of the effector molecules perforin and granzyme B when stimulated with IL-15, thereby promoting a strong cytotoxic response. In skin from patients with vitiligo, where melanocytes are eradicated locally, CD8+CD49a+ Trm cells that constitutively expressed perforin and granzyme B accumulated both in the epidermis and dermis. Conversely, CD8+CD49a– Trm cells from psoriasis lesions predominantly generated IL-17 responses that promote local inflammation in this skin disease. Overall, CD49a expression delineates CD8+ Trm cell specialization in human epithelial barriers and correlates with the effector cell balance found in distinct inflammatory skin diseases., Graphical Abstract, Highlights • CD49a expression marks CD8+ Trm cells poised for IFN-γ production in human skin • IL-15 drives potent cytotoxic capacity in CD49a+ Trm cells • IL-17 is preferentially produced by CD49a− CD8+ Trm cells in the skin • CD49a+ versus CD49- Trm cell functional dichotomy is preserved in vitiligo and psoriasis, Tissue-resident memory T (Trm) cells provide localized adaptive immunity in peripheral tissues. Cheuk et al. identify cytotoxic CD49a+CD8+ Trm cells and IL-17-producing CD49a−CD8+ Trm cells in healthy human skin. The functional dichotomy of pathogenic Trm cells based on CD49a expression is preserved in focal skin diseases vitiligo and psoriasis.
- Published
- 2016
15. Dynamic Changes in Resident and Infiltrating Epidermal Dendritic Cells in Active and Resolved Psoriasis
- Author
-
Elisa, Martini, Maria, Wikén, Stanley, Cheuk, Irène, Gallais Sérézal, Faezzah, Baharom, Mona, Ståhle, Anna, Smed-Sörensen, and Liv, Eidsmo
- Subjects
Microscopy, Confocal ,Biopsy, Needle ,Interleukin-17 ,Toll-Like Receptors ,Cell Differentiation ,Dendritic Cells ,Flow Cytometry ,Real-Time Polymerase Chain Reaction ,Immunohistochemistry ,Interleukin-23 ,Sampling Studies ,Statistics, Nonparametric ,Epidermal Cells ,Reference Values ,Langerhans Cells ,Cytokines ,Humans ,Psoriasis - Abstract
Epidermal Langerhans cells (LCs) are spatially separated from dermal dendritic cells (DCs) in healthy human skin. In active psoriasis, maintained by local production of IL-23 and IL-17, inflammatory DCs infiltrate both skin compartments. Here we show that CCR2
- Published
- 2016
16. Cutaneous metastasis of gastric adenocarcinoma at the site of a traumatic ecchymosis
- Author
-
Irène, Gallais Sérézal, Simona, Dumitru, Christine, Le Foll, and Brigitte, Hillion
- Subjects
Male ,Laparotomy ,Skin Neoplasms ,Stomach Neoplasms ,Humans - Published
- 2015
17. Images in clinical medicine. Atypical ulcerations of the penis
- Author
-
Irène, Gallais Sérézal and Brigitte, Hillion
- Subjects
Male ,Penile Diseases ,Sodium Hypochlorite ,Skin Ulcer ,Humans ,Aged ,Penis - Published
- 2015
18. Atypical Ulcerations of the Penis
- Author
-
Brigitte Hillion and Irène Gallais Sérézal
- Subjects
medicine.medical_specialty ,business.industry ,Diethylstilbestrol ,Urology ,Cancer ,Urinary incontinence ,General Medicine ,medicine.disease ,Surgery ,Prostate cancer ,medicine.anatomical_structure ,medicine ,medicine.symptom ,business ,Penis ,medicine.drug - Abstract
A 73-year-old man presented with a 3-month history of painful ulcers of the penis. He had a history of urinary incontinence after undergoing surgery for prostate cancer 6 years earlier; his cancer was being treated with diethylstilbestrol.
- Published
- 2015
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.