1. Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients
- Author
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Qi Song, Yanqiu Wang, Hao Wang, Dongxian Jiang, Chen Xu, Jieakesu Su, Yingyong Hou, Zhengzeng Jiang, Lijie Tan, and Xin Wang
- Subjects
0301 basic medicine ,Oncology ,Male ,Cancer Research ,Esophageal Neoplasms ,Gene Dosage ,0302 clinical medicine ,Esophageal squamous cell carcinoma (ESCC) ,Surgical oncology ,Gene duplication ,Fluorescence in situ hybridization (FISH) ,Medicine ,Copy-number variation ,Stage (cooking) ,In Situ Hybridization, Fluorescence ,Aged, 80 and over ,Tissue microarray ,medicine.diagnostic_test ,Hazard ratio ,Increased MET gene copy number ,Middle Aged ,Proto-Oncogene Proteins c-met ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,030220 oncology & carcinogenesis ,Female ,Esophageal Squamous Cell Carcinoma ,Research Article ,Adult ,medicine.medical_specialty ,lcsh:RC254-282 ,Disease-Free Survival ,03 medical and health sciences ,Esophagus ,Statistical significance ,Internal medicine ,Genetics ,Biomarkers, Tumor ,Humans ,Aged ,Neoplasm Staging ,Retrospective Studies ,business.industry ,Gene Amplification ,Survival Analysis ,Clinical stage ,030104 developmental biology ,Tissue Array Analysis ,business ,Fluorescence in situ hybridization - Abstract
Backgrounds Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, its clinical pathologic characteristics are not well known in esophageal squamous cell carcinoma (ESCC). Methods We investigated MET gene status with fluorescence in situ hybridization (FISH) assay in 495 ESCC cases using tissue microarrays. Prognostic significance as well as correlations with various clinicopathological parameters was evaluated. Results Among 495 patients, 28 (5.7%) cases were MET FISH positive, including 5 cases (1%) with true gene amplification. There were no statistically significant associations between MET FISH-positivity and clinicopathologic characteristics. A significantly poorer prognosis was observed in 28 patients with MET FISH-positivity (disease free survival/DFS, P
- Published
- 2018