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Indigestible fiber-protein-phytate complexes reduce feeding value of soy products. We investigated effects of multi-enzyme supplement (MES) on standardized ileal digestibility (SID) of AA and DE content in expeller soybean meal (ESBM) and roasted full fat soybean seed (FFSB) fed to growing pigs. The ESBM was a commercial product and FFSB was roasted at 118–120°C for 75 min in a local farm. The CP was 42.8 and 33.4% DM in ESBM and FFSB, respectively and corresponding values for crude fat were 11.8 and 17.4% DM. Semi-purified diets with 50% of either ESBM or FFSB as sole source of AA were prepared without or with MES supplying phytase, protease, xylanase, β-glucanase at 1,500, 5,625, 270 and 70 U/kg of feed, respectively. Diets had TiO(2) indigestible marker and ratio of cornstarch to sucrose and corn oil was identical to our published N-free diet to calculate DE by difference method. Eight ileal-cannulated barrows (BW = 22.1 ± 0.61 kg) were fed 4 diets in a replicated 4 × 4 Latin square design (n=8). Period lasted for 9 d; 5-d for acclimation, 2-d for fecal and 2-d for ileal digesta samples collection. Fixed effects of soy product, MES and two-way interactions were evaluated. There was no (P>0.05) interaction or MES effect on AID and SID of CP and AAs, except AID and SID of Phe (P0.05) interaction or MES effect on apparent total tract digestibility (ATTD) except on CF (P