1. In vitro biocompatibility testing of polymeric nanofiber scaffolds: fine-tuning for a better prediction of the in vivo behaviour
- Author
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Khaimov Valeria, Klußmann-Fricke Bastian-Jesper, Illner Sabine, Siewert Stefan, and Schmitz Klaus-Peter
- Subjects
biocompatibility ,Biomedical Engineering ,Medicine ,hemocompatibility ,plla ,tspcu ,electrospinning ,endothelialization ,nonwovens - Abstract
Biomaterial research efforts focus on the development of biomaterials that mimic the natural extracellular environment. In addition, different strategies are applied to render materials for blood-contacting devices nonthrombogenic through surface modifications that would suppress activation of platelets, coagulation and the complement system. A confluent thin layer of endothelial cells lines all blood vessels and produces factors responsible for inhibition of coagulation, thrombosis and neointimal hyperplasia. Thus, the ability to rapidly form a healthy endothelium upon implantation represents a desired property of biomaterials used for cardiovascular devices. In this study we used advanced in vitro methods to investigate the biocompatibility of a biodegradable and a permanent electrospun nanofiber fabric, poly-L-lactic acid and polycarbonate-based silicone elastomer respectively, with the focus on endothelialization and hemocompatibility.
- Published
- 2021