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Among the various fused heterocyclic rings, benzothiazole and its analogs have been explored broadly in search of newer therapeutic medicinal agents. The benzothiazole scaffold has been associated with huge biological potential like anticancer, antidiabetic, anti-inflammatory, antitubercular, antiviral, anti-convulsant etc. The occurrence of benzothiazole core in various compounds proves its value in the sphere of pharmaceutical chemistry. The connected research and developments in benzothiazole based chemistry become an active topic for medicinal scientists. A large number of benzothiazole and its heterocyclic derivatives are available in the market and used for the treatment as clinical drugs have been extensively used in practice to treat diverse types of ailments with high therapeutic potential. This review presents the latest therapeutic developments of benzothiazole containing compounds in the medicinal chemistry.

The paper presents a non conventional technique to predict the constitutive behavior of materials by assessing the true stress–true strain relationship through miniature specimen tests. The miniature test was conducted on two different types of steel ring specimens (outer diameter14mm, inner diameter 8mm, thickeness 0.5mm) with V-notch (1mm depth) added diametrically to it. A finite element model was developed and validated to calculate the load–deflection curve obtained from the miniature specimen experiment. The constitutive behavior assigned to the specimen for the calculations was determined from the standard tensile test. Using an inverse methodology, it was possible to show that the constitutive behavior from the miniature tests using inverse FE procedure, and that from the conventional standard ASTM test bears close resemblance.