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2 results on '"Huot, Philippe"'

1. Development and validation of a sensitive HPLC-HESI-MS/MS method for quantitative determination of bitopertin in rat and marmoset plasma

Author

Frouni, Imane and Huot, Philippe

Subjects
marmoset plasma, Medical Sciences, Chemical and Pharmacologic Phenomena, animal diseases, bioanalysis, HPLC-HESI-MS/MS, Medicine and Health Sciences, Life Sciences, rat plasma, bitopertin, pharmacokinetics
Abstract

The objective of this study was to develop and validate a sensitive and selective high-performance liquid chromatography coupled with heat assisted electrospray ionisation tandem mass spectrometry (HPLC-HESI-MS/MS) assay to quantify bitopertin in the rat (Sprague-Dawley) and the common marmoset (Callithrix jacchus) plasma after administration of 1.0 mg/kg subcutaneously.

Published
2022
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2. Additional file 1 of Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer’s disease

Author

Tissot, Cécile, Benedet, Andréa L., Therriault, Joseph, Tharick A. Pascoal, Firoza Z. Lussier, Paramita Saha-Chaudhuri, Chamoun, Mira, Savard, Melissa, Sulantha S. Mathotaarachchi, Bezgin, Gleb, Wang, Yi-Ting, Arias, Jaime Fernandez, Rodriguez, Juan Lantero, Snellman, Anniina, Ashton, Nicholas J., Karikari, Thomas K., Blennow, Kaj, Zetterberg, Henrik, Villers-Sidani, Etienne De, Huot, Philippe, Gauthier, Serge, and Rosa-Neto, Pedro

Abstract

Additional file 1: Supplementary Figure 1. Correlations maps (R-maps) of cross-sectional analyses, in both CU and CI groups. Supplementary Figure 2. Longitudinal changes of plasma pTau181 in each individual. Supplementary Figure 3. Longitudinal plasma pTau181 changes among cognitively unimpaired and cognitively impaired individuals, stratified by Aβ status.

Published
2021
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