145 results on '"Huijun Jiang"'
Search Results
2. Research on the influence of physical exercise on insomnia and suicide of college students
- Author
-
Huiming Xu and Huijun Jiang
- Subjects
Bioengineering ,Molecular Biology ,Biotechnology - Published
- 2023
3. Analysis of the characteristics of blood lipid metabolism in twin pregnancy
- Author
-
Yanqin Lou, Pei He, Huijun Jiang, Li Xiang, and Xuemei Gao
- Subjects
General Medicine ,General Biochemistry, Genetics and Molecular Biology - Abstract
Objective: This study aimed to investigate the characteristics of blood lipid metabolism in twin pregnancy and its combined with gestational diabetes mellitus (GDM) or pregnancy-induced hypertension (PIH). Methods: This study retrospectively analyzed 96 cases of twin pregnancy and 232 cases of full-term singleton pregnancy, and they were filed in our hospital, undergone antenatal examination and gave birth from March 2016 to March 2021. Among 96 cases of twin pregnancy, 22 cases had GDM, and 18 cases had gestational hypertension. Comparison of general data and blood lipid levels, including triglyceride (TG) and total cholesterol (TC), between twin pregnancy and singleton pregnancy was performed. Comparison of blood lipid levels between GDM group and non-GDM group in twin pregnancy was performed. Comparison of blood lipid levels between the PIH group and the non-PIH group in twin pregnancy was performed. Results For the twin pregnancy, the TG level in the third trimester was higher than that in the second and first trimester, and the TG level in the second trimester was higher than that in the first trimester (P 0.05). The TG level of twin pregnancy was higher than that of singleton pregnancy in the first, second and third trimesters (P 0.05). For the twin pregnancy, the TG level in the GDM group was higher than that in the non-GDM group (P 0.05). The TG level in the first, second and third trimester of twin pregnancy combined with PIH group was higher than that in the non-hypertensive group (P 0.05). Conclusions The lipid levels in twin pregnancy increased with the increase of gestational age, and the TG level in twin pregnancy complicated with GDM or PIH was higher than that in twin pregnancy without with GDM or PIH, indicating that the blood lipid metabolism was related to the occurrence of GDM and PIH in twin pregnancy to some extent.
- Published
- 2023
4. Lattice mismatch induced tunable dimensionality of transition metal Di-chalcogenides
- Author
-
Hanxiao Dong, Huijun Jiang, and Zhonghuai Hou
- Subjects
Physical and Theoretical Chemistry - Abstract
Low-dimensional materials have excellent properties which are closely related to their dimensionality. However, the growth mechanism underlying tunable dimensionality from 2D triangles to ID ribbons of such materials is still unrevealed. Here, we establish a general kinetic Monte Carlo model for transition metal dichalcogenides (TMDs) growth to address such an issue. Our model is able to reproduce several key ñndings in experiments, and reveals that the dimensionality is determined by the lattice mismatch and the interaction strength between TMDs and the substrate. We predict that the dimensionality can be well tuned by the interaction strength and the geometry of the substrate. Our work deepens the understanding of tunable dimensionality of low-dimensional materials and may inspire new concepts for the design of such materials with expected dimensionality.
- Published
- 2022
5. Profile design of twin screw air compressor for fuel cell
- Author
-
Maofei Geng, Le Wang, Dong Cui, Xiaosa Li, Jinlu Li, and Huijun Jiang
- Subjects
General Energy - Published
- 2022
6. Classification of disease recurrence using transition likelihoods with expectation‐maximization algorithm
- Author
-
Huijun Jiang, Quefeng Li, Jessica T. Lin, and Feng‐Chang Lin
- Subjects
Statistics and Probability ,Motivation ,Recurrence ,Epidemiology ,Humans ,Algorithms ,Markov Chains ,Probability - Abstract
When an infectious disease recurs, it may be due to treatment failure or a new infection. Being able to distinguish and classify these two different outcomes is critical in effective disease control. A multi-state model based on Markov processes is a typical approach to estimating the transition probability between the disease states. However, it can perform poorly when the disease state is unknown. This article aims to demonstrate that the transition likelihoods of baseline covariates can distinguish one cause from another with high accuracy in infectious diseases such as malaria. A more general model for disease progression can be constructed to allow for additional disease outcomes. We start from a multinomial logit model to estimate the disease transition probabilities and then utilize the baseline covariate's transition information to provide a more accurate classification result. We apply the expectation-maximization (EM) algorithm to estimate unknown parameters, including the marginal probabilities of disease outcomes. A simulation study comparing our classifier to the existing two-stage method shows that our classifier has better accuracy, especially when the sample size is small. The proposed method is applied to determining relapse vs reinfection outcomes in two Plasmodium vivax treatment studies from Cambodia that used different genotyping approaches to demonstrate its practical use.
- Published
- 2022
7. Perspective on This Article from Loss of Heterozygosity (LOH) Profiles—Validated Risk Predictors for Progression to Oral Cancer
- Author
-
Miriam P. Rosin, J. Jack Lee, Lang Wu, Huijun Jiang, Pamela J. Gardner, Ken Berean, Denise M. Laronde, Michele Williams, Catherine F. Poh, and Lewei Zhang
- Abstract
Perspective on This Article from Loss of Heterozygosity (LOH) Profiles—Validated Risk Predictors for Progression to Oral Cancer
- Published
- 2023
8. H2O2 Self-Supplementing and GSH-Depleting Nanoreactors Based on MoO3–x@Fe3O4-GOD-PVP for Photothermally Reinforced Nanocatalytic Cancer Therapy at the Second Near-Infrared Biowindow
- Author
-
Fan Wu, Changgao Huang, Baohong Sun, Zhihui Zhu, Wenquan Cheng, Yanjun Chen, Chenhao Liao, Ruping Xu, Mihai’ernisaguli Maimaititu’ersun, Ninglin Zhou, Feng Han, Zheng Cai, and Huijun Jiang
- Subjects
Renewable Energy, Sustainability and the Environment ,General Chemical Engineering ,Environmental Chemistry ,General Chemistry - Published
- 2022
9. Motility-induced phase separation is reentrant
- Author
-
Jie Su, Mengkai Feng, Yunfei Du, Huijun Jiang, and Zhonghuai Hou
- Subjects
General Physics and Astronomy - Abstract
Active Brownian particles (ABPs) with pure repulsion is an ideal model to understand the effect of nonequilibrium on collective behaviors. It has long been established that activity can create effective attractions leading to motility-induced phase separation (MIPS), whose role is similar to that of (inverse) temperature in the simplest equilibrium system with attractive inter-particle interactions. Here, we report that activity can lead to a counterintuitive reentrant MIPS, which is completely different from the phase behavior of equilibrium systems, shown by both simulations and theory. Our theoretical analysis based on a kinetic theory of MIPS shows that an additional term of activity-induced nonequilibrium vaporization is able to hinder the formation of dense phase when activity is large enough. Such effect along with the activity-induced effective attraction thus lead to the MIPS reentrance. Numerical simulations verify this nonequilibrium effect induced solely by activity on phase behaviors of ABPs, and further demonstrate the dependence of MIPS on activity and the strength of inter-particle interaction predicted by our theoretical analysis. Our findings highlight the particular role played by the nonequilibrium nature of activity on phase behaviors of active systems, which may inspire deep insights into the essential difference between equilibrium and nonequilibrium systems.
- Published
- 2023
10. The effect of a brief, unplanned treatment delay on neovascular age-related macular degeneration patients: a retrospective cohort study
- Author
-
Jason Adam Zehden, Arko Ghosh, Srinath Soundararajan, Tamy Harumy Moraes Tsujimoto, Huijun Jiang, Feng-Chang Lin, Tyler Blahnik, David Fleischman, and Alice Yang Zhang
- Subjects
Multidisciplinary - Abstract
Non-compliance to intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy can result in increased disease activity in neovascular age-related macular degeneration (nAMD). Our study aims to determine effects of unplanned delay in anti-VEGF injection treatment for nAMD. This retrospective observational study included patients with delays in receiving intravitreal injections for nAMD treatment from March to May 2020 by at least 21 days. Baseline demographic and clinical characteristics, visual acuity (VA), central macular thickness (CMT) measured on optical coherence tomography (OCT), and duration of delayed treatment were analyzed for 3 time points, the pre-delay visit (v1) and post-delay visits (v2 and v3). Data were compared to age-matched controls treated for nAMD in 2019 without delay. Demographic characteristics were compared using two-sample t-tests for continuous variables and Pearson’s chi-square tests for categorical variables. For the two primary outcomes of interest, VA and CMT, means and standard deviations were reported for each combination of group and time. Each outcome was modeled using a linear mixed model with the group, time and group-time interaction as fixed effects. A total of 69 patients (99 eyes) in the treatment delay group and 44 patients (69 eyes) in the control group were identified. Statistically significant differences between control and delayed groups were detected for VA (difference in mean logMAR = 0.16; 95% CI 0.06, 0.27; p = 0.002) and CMT (difference in mean CMT = 29; 95% CI 12, 47; p = 0.001) at v2. No differences were detected for v1 and v3 time points for both outcomes. An unplanned delay in intravitreal injection treatment for nAMD resulted in an increase in CMT and worsening of VA compared to controls observed at v2. At v3, CMT and VA recovered to near v1 levels. This study demonstrates that a one-time, brief interruption in treatment for nAMD results in reversible, temporary worsening.
- Published
- 2023
11. Surface Engineering on Commercial Cu Foil for Steering C2H4/CH4 Ratio in CO2 Electroreduction
- Author
-
Peiquan Ling, Yinghuan Liu, Zhiqiang Wang, Li Li, Jun Hu, Junfa Zhu, Wensheng Yan, Huijun Jiang, Zhonghuai Hou, Yongfu Sun, and Yi Xie
- Subjects
Mechanical Engineering ,General Materials Science ,Bioengineering ,General Chemistry ,Condensed Matter Physics - Published
- 2022
12. The Endosperm-Specific Expression of YUCCA Genes Enhances Rice Grain Filling
- Author
-
Huijun Jiang, Kaien Zhai, Xiaofan Ye, Tianwei Hu, Jieming Jiang, Xiaoqiu Dong, Weihuai Pan, Jianwei Pan, and Jianxin Shou
- Subjects
Physiology ,Plant Science ,Biochemistry - Published
- 2022
13. Cardiovascular Disease Risk Estimation for Transgender and Gender-Diverse Patients: Cross-Sectional Analysis of Baseline Data From the LITE Plus Cohort Study
- Author
-
Tonia C. Poteat, Ashleigh J. Rich, Huijun Jiang, Andrea L. Wirtz, Asa Radix, Sari L. Reisner, Alexander B. Harris, Christopher M. Cannon, Catherine R. Lesko, Mannat Malik, Jennifer Williams, Kenneth H. Mayer, and Carl G. Streed
- Published
- 2023
14. Nonequilibrium Dynamics of Chemically Active Particles
- Author
-
Zhonghuai Hou and Huijun Jiang
- Subjects
Chemical physics ,Chemistry ,Active particles ,Dynamics (mechanics) ,Non-equilibrium thermodynamics ,General Chemistry ,Multiscale modeling - Published
- 2021
15. Local Field Induced Mass Transfer: New Insight into Nano‐electrocatalysis
- Author
-
Zhonghuai Hou, Huijun Jiang, and Ying-Huan Liu
- Subjects
Electron transfer ,Chemistry ,Mass transfer ,Electric field ,Organic Chemistry ,Electrode ,Nano ,Nanotechnology ,General Chemistry ,Electrocatalyst ,Local field ,Catalysis ,Nanomaterial-based catalyst - Abstract
Unravelling the complex kinetics of electrocatalysis is essential for the design of electrocatalysts with high performance. Mass transfer and electron transfer are two primary factors that need to be optimized in order to enhance electrocatalytic reactions. The use of nanocatalysts proves to be a promising way of promoting the performance of electrocatalytic reactions, this improvement is usually attributed to their ability to enhance electron transfer. However, when catalysts are taken down to the nanoscale, their size is comparable to the thickness of an electrical double layer, so any curvature can lead to an inhomogeneous local electric field on the electrode, which then changes the mass transfer essentially. In this article, we introduce the new concept of local-field-induced mass transfer in nano-electrocatalytic systems, and provide a brief review of recent progress, revealing its effect on nano-electrocatalysis, which may bring new insight into the future design of nano-electrocatalysts.
- Published
- 2021
16. Design method of air compressor rotor profile for fuel cell
- Author
-
Maofei Geng, Le Wang, Dong Cui, Xiaosa Li, Jinlu Li, and Huijun Jiang
- Published
- 2022
17. Microchemical Engineering in a 3D Ordered Channel Enhances Electrocatalysis
- Author
-
Wei-Ran Huang, Zhonghuai Hou, Huijun Jiang, Ying-Huan Liu, Guanyin Gao, Zhen He, Shu-Hong Yu, Jian-Wei Liu, Jin-Long Wang, and Qing-Xia Chen
- Subjects
Chemistry ,Kinetics ,General Chemistry ,Electrocatalyst ,Biochemistry ,Redox ,Catalysis ,Reaction rate ,Colloid and Surface Chemistry ,Chemical engineering ,Mass transfer ,Electrode ,Microreactor - Abstract
The kinetics of electrode reactions including mass transfer and surface reaction is essential in electrocatalysis, as it strongly determines the apparent reaction rates, especially on nanostructured electrocatalysts. However, important challenges still remain in optimizing the kinetics of given catalysts with suitable constituents, morphology, and crystalline design to maximize the electrocatalytic performances. We propose a comprehensive kinetic model coupling mass transfer and surface reaction on the nanocatalyst-modified electrode surface to explore and shed light on the kinetic optimization in electrocatalysis. Moreover, a theory-guided microchemical engineering (MCE) strategy has been demonstrated to rationally redesign the catalysts with optimized kinetics. Experimental measurements for methanol oxidation reaction in a 3D ordered channel with tunable channel sizes confirm the calculation prediction. Under the optimized channel size, mass transfer and surface reaction in the channeled microreactor are both well regulated. This MCE strategy will bring about a significant leap forward in structured catalyst design and kinetic modulation.
- Published
- 2021
18. Electrospun chitosan oligosaccharide/polycaprolactone nanofibers loaded with wound-healing compounds of Rutin and Quercetin as antibacterial dressings
- Author
-
Jun Wang, Li Zhang, Huijun Jiang, Jin Chen, Shanwu Feng, Ling Cai, Yuan Wu, Liuzhu Zhou, and Hongjie Ruan
- Subjects
Staphylococcus aureus ,Polyesters ,Rutin ,Nanofibers ,Microbial Sensitivity Tests ,02 engineering and technology ,Biochemistry ,Chitosan ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Structural Biology ,Escherichia coli ,Animals ,Molecular Biology ,030304 developmental biology ,Wound Healing ,0303 health sciences ,integumentary system ,technology, industry, and agriculture ,Membranes, Artificial ,General Medicine ,equipment and supplies ,021001 nanoscience & nanotechnology ,Bandages ,Electrospinning ,Anti-Bacterial Agents ,Membrane ,chemistry ,Nanofiber ,Polycaprolactone ,NIH 3T3 Cells ,Quercetin ,0210 nano-technology ,Wound healing ,Hydrophobic and Hydrophilic Interactions ,Nuclear chemistry - Abstract
Burn injury has posed devastating burdens on the public health due to its inevitable damage to the skin structure resulting in the increased risk of infection. Therefore, it is highly demanding to develop efficacious antibacterial wound-healing dressing. Despite the favourable wound-healing activities, the curative efficacy of phytochemical compounds of quercetin (Qe) and its derivatives is limited by their poor water solubility. Here, we have fabricated a novel electrospun nanofiber membrane (ENM) consisting of polycaprolactone (PCL), chitosan oligosaccharides (COS), and Qe/Rutin (Ru) as the potential bioactive dressing for wound healing. The incorporation of chitosan oligosaccharides (COSs) in the PCL scaffold at the optimized molar ratio not only contributed to the improved hydrophilicity and water absorption performance of the ENM but effectively increased the specific surface area of the formed nanofibers. In particular, the antioxidant and antibacterial activities of the Qe/rutin-loaded nanofiber membranes were tested, which revealed that the PCL-COS-Qe membrane exhibited superior performance among all nanofiber membranes. Therefore, the developed PCL-COS-Qe/Ru nanofiber membranes hold enormous potential as healthcare products, such as wound dressings for burn injuries.
- Published
- 2021
19. Curcumin-stabilized silver nanoparticles encapsulated in biocompatible electrospun nanofibrous scaffold for sustained eradication of drug-resistant bacteria
- Author
-
Ling Cai, Xinyi Zhu, Hongjie Ruan, Jing Yang, Wei Wei, Yuan Wu, Liuzhu Zhou, Huijun Jiang, Minghui Ji, and Jin Chen
- Subjects
Environmental Engineering ,Health, Toxicology and Mutagenesis ,Environmental Chemistry ,Pollution ,Waste Management and Disposal - Published
- 2023
20. Deciphering the photoactive species-directed antibacterial mechanism of bismuth oxychloride with modulated nanoscale thickness
- Author
-
Liuzhu Zhou, Xinyi Zhu, Jing Yang, Ling Cai, Li Zhang, Huijun Jiang, Hongjie Ruan, and Jin Chen
- Subjects
Environmental Engineering ,General Medicine ,Management, Monitoring, Policy and Law ,Waste Management and Disposal - Published
- 2023
21. Characteristics of sudden death by clinical criteria
- Author
-
Christopher Sefton, Susan Keen, Caroline Tybout, Feng-Chang Lin, Huijun Jiang, Golsa Joodi, Jefferson G. Williams, and Ross J. Simpson
- Subjects
General Medicine - Published
- 2023
22. Hidden Mechanism Behind the Roughness‐Enhanced Selectivity of Carbon Monoxide Electrocatalytic Reduction
- Author
-
Yinghuan Liu, Huijun Jiang, and Zhonghuai Hou
- Subjects
Materials science ,010405 organic chemistry ,General Medicine ,General Chemistry ,Surface finish ,010402 general chemistry ,Electrocatalyst ,01 natural sciences ,Catalysis ,Nanomaterial-based catalyst ,0104 chemical sciences ,chemistry.chemical_compound ,Adsorption ,Chemical engineering ,chemistry ,Mass transfer ,Selectivity ,Carbon monoxide - Abstract
High roughness has been proved to be an effective design strategy for electrocatalyst in many systems. Especially, high selectivity of carbon monoxide reduction (CORR) in competition with the hydrogen evolution reaction has been observed on high roughness electrocatalysts. However, the two well-known mechanisms, i.e., decreasing the energy barrier of CORR and increasing local pH, failed to understand the roughness-enhanced selectivity in a recent experiment. Herein we unravel the hidden mechanism by establishing a comprehensive kinetic model for CORR on catalysts with different roughness factors. We conclude that the roughness-enhanced CORR selectivity is actually kinetic controlled by local-electric-field-directed mass transfer of adsorbed species on the electrode surface. Several ways to optimize CORR selectivity are predicted. Our work highlights the kinetics in electrocatalysis on nanocatalysts, and provides a conceptually new principle for future catalyst design.
- Published
- 2021
23. Simulation study of passive rod diffusion in active bath: Nonmonotonic length dependence and abnormal translation-rotation coupling
- Author
-
Zhonghuai Hou, Rui-kai Xu, and Huijun Jiang
- Subjects
Physics ,Condensed matter physics ,Isotropy ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Coupling (probability) ,Space (mathematics) ,Translation (geometry) ,Rotation ,01 natural sciences ,Length dependence ,0104 chemical sciences ,Normal diffusion ,Physical and Theoretical Chemistry ,Diffusion (business) ,0210 nano-technology - Abstract
Diffusion of tracer particles in active bath has attracted extensive attention in recent years. So far, most studies have considered isotropic spherical tracer particles, while the diffusion of anisotropic particles has rarely been involved. Here we investigate the diffusion dynamics of a rigid rod tracer in a bath of active particles by using Langevin dynamics simulations in a two-dimensional space. Particular attention is paid to how the translation (rotation) diffusion coefficient \begin{document}$ D_{ \rm{T}} $\end{document} ( \begin{document}$ D_{ \rm{R}} $\end{document} ) change with the length of rod \begin{document}$ L $\end{document} and active strength \begin{document}$ F_{ \rm{a}} $\end{document} . In all cases, we find that rod exhibits superdiffusion behavior in a short time scale and returns to normal diffusion in the long time limit. Both \begin{document}$ D_{ \rm{T}} $\end{document} and \begin{document}$ D_{ \rm{R}} $\end{document} increase with \begin{document}$ F_{ \rm{a}} $\end{document} , but interestingly, a nonmonotonic dependence of \begin{document}$ D_{ \rm{T}} $\end{document} ( \begin{document}$ D_{ \rm{R}} $\end{document} ) on the rod length has been observed. We have also studied the translation-rotation coupling of rod, and interestingly, a negative translation-rotation coupling is observed, indicating that rod diffuses more slowly in the parallel direction compared to that in the perpendicular direction, a counterintuitive phenomenon that would not exist in an equilibrium counterpart system. Moreover, this anomalous (diffusion) behavior is reentrant with the increase of \begin{document}$ F_{ \rm{a}} $\end{document} , suggesting two competitive roles played by the active feature of bath particles.
- Published
- 2021
24. Encapsulating MoS2-nanoflowers conjugated with chitosan oligosaccharide into electrospun nanofibrous scaffolds for photothermal inactivation of bacteria
- Author
-
Qilan Xu, Li Zhang, Yuhui Liu, Ling Cai, Liuzhu Zhou, Huijun Jiang, and Jin Chen
- Published
- 2022
25. One-pot synthesis of α-Linolenic acid nanoemulsion-templated drug-loaded silica mesocomposites as efficient bactericide against drug-resistant Mycobacterium tuberculosis
- Author
-
Ping Zhu, Ling Cai, Qiao Liu, Shanwu Feng, Hongjie Ruan, Li Zhang, Liuzhu Zhou, Huijun Jiang, Hongsheng Wang, Jianming Wang, and Jin Chen
- Subjects
Staphylococcus aureus ,Tuberculosis, Multidrug-Resistant ,Pharmaceutical Science ,Humans ,Nanoparticles ,alpha-Linolenic Acid ,Mycobacterium tuberculosis ,Rifampin ,Silicon Dioxide ,Anti-Bacterial Agents - Abstract
Nowadays, pathogenic infection has posed a severe threat to the public health and environmental sanitation, urging a continuous search of efficacious and safe bactericidal agents of various formulated forms. Here, a facile one-pot hydrothermal preparation of mesoporous silica nanoparticles using ultrasonication-assisted nanoemulsion of α-Linolenic acid (α-LA) as template was developed. The formed silica mesocomposite at water/fatty-acid surface provides an easy yet green synthesis route, which can be generalized for the further encapsulation of hydrophobic drugs such as antimycobacterial Rifampicin (RIF). The obtained α-LA nanoemulsion-templated silica nanoparticles (LNS NPs), with a weight content of ∼17% α-LA in the composite, showed apparent antibacterial effect against Staphylococcus aureus (S. aureus). By comparison, the removal of α-LA from the silica nanoparticles (LNS-1 NPs) resulted in the composite of enlarged pore size with negligible bactericidal activities. Notably, the Isoniazide (INH) and Rifampicin (RIF)-encapsulated LNS NPs exhibited outstanding antimycobacterial activity against both drug-sensitive and drug-resistant Mycobacterium tuberculosis (M. tuberculosis). The obtained highly biocompatible, biosafe and low-energy consumptive α-LA-contained mesostructured silica-based bactericide holds promising therapeutic potentials to tackle the emerging drug-resistant infectious microbes.
- Published
- 2022
26. A Stacked Plasmonic Metamaterial with Strong Localized Electric Field Enables Highly Efficient Broadband Light-Driven CO
- Author
-
Tianyi, Shao, Xiaonong, Wang, Hanxiao, Dong, Shengkun, Liu, Delong, Duan, Yaping, Li, Pin, Song, Huijun, Jiang, Zhonghuai, Hou, Chao, Gao, and Yujie, Xiong
- Abstract
Light utilization largely governs the performance of CO
- Published
- 2022
27. Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes
- Author
-
Boshen Zhou, Qian Tong, Luming Peng, Yuanyuan Duan, Xudong Hang, Huijun Jiang, Liu Qiao, Ling Cai, Jianming Wang, Peipei Luo, Hongkai Bi, Huang Yanqiang, Jin Chen, Jia Jia, Liping Zeng, Ping Zhu, Qilan Xu, Yujie Wen, Qian Wu, and Yanmei Yang
- Subjects
02 engineering and technology ,Drug resistance ,engineering.material ,010402 general chemistry ,medicine.disease_cause ,01 natural sciences ,Bacterial cell structure ,Microbiology ,medicine ,General Materials Science ,Electrical and Electronic Engineering ,Candida albicans ,biology ,Chemistry ,Biofilm ,Mesoporous silica ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Antimicrobial ,biology.organism_classification ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Staphylococcus aureus ,engineering ,Biopolymer ,0210 nano-technology - Abstract
Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health, especially among immunocompromised populations. Given the intricate problem of dramatic increase in resistance to common biocides, the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly demanding. In this study, Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine (e-PL) decorated aldehyde functionalized mesoporous silica SBA-15 (CHO-SBA-15) for the selective coordination of silver ions, which was affirmed by various physicochemical methods. Besides the identified broad-spectrum antibacterial activities, the as-prepared Schiff-base silver nanocomplex (CHO-SBA-15/e-PL/Ag, CLA-1) exhibited an improved inhibitory effect on infectious pathogen growth typified by Escherichia coli and Staphylococcus aureus in comparison with two control silver complexes without Schiff-base conjugates, SBA-15/e-PL/Ag and CHO-SBA-15/Ag, respectively. In addition, CLA-1 remarkably inhibited the growth of Mycobacterium tuberculosis due to the excellent antimicrobial activity of silver species. Significantly, CLA-1 kills Candida albicans cells, inhibits biofilm formation, and eliminates preformed biofilms, with no development of resistance during continuous serial passaging. The antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen species. In mouse models of multidrug-resistant C. albicans infection, CLA-1 exhibited efficient in vivo fungicidal efficacy superior to two antifungal drugs, amphotericin B and fluconazole. Moreover, CLA-1 treatment induces negligible toxicity against normal tissues with safety. Therefore, this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes.
- Published
- 2021
28. Evaluation of the gut microbiome alterations in healthy rats after dietary exposure to different synthetic ZnO nanoparticles
- Author
-
Xinyi, Zhu, Henghui, Li, Liuzhu, Zhou, Huijun, Jiang, Minghui, Ji, and Jin, Chen
- Subjects
General Medicine ,General Pharmacology, Toxicology and Pharmaceutics ,General Biochemistry, Genetics and Molecular Biology - Abstract
Although synthetic ZnO nanoparticles (Nano-ZnO) as an alternative of ZnO compounds have been extensively used such as in livestock production, the increased consuming of Nano-ZnO has raised considerable concerns in environmental pollution and public health. Because of the low digestion of Nano-ZnO, the systematic studies on their interactions with gut microbiota remain to be clarified.Nano-ZnOs were prepared by co-precipitation (ZnO-cp) and high temperature thermal decomposition (ZnO-td) as well as the commercial type (ZnO-s). Transmission electron microscopy (TEM) was used to monitor the morphology of Nano-ZnO. CCK-8 assay was used for cytotoxicity evaluation. Total antioxidant capacity assay, total superoxide dismutase assay, and lipid peroxidation assay were used to evaluate oxidative states of rats. 16S rRNA was used to study the impact of Nano-ZnO on the rat gut microbiome.Both ZnO-cp and ZnO-td exhibited low cytotoxicity while ZnO-s and ZnO-td exhibited prominent antibacterial activities. After a 28-day oral feeding with 1000 mg/kg Zn at dietary dosage, ZnO-s showed slight effect on causing oxidative stress in comparison with that of ZnO-cp and ZnO-td. Results of 16S rRNA sequencing analysis indicated that ZnO-td as a promising short-term nano-supplement can increase probiotics abundances like strains belonged to the genus Lactobacillus and provide the antipathogenic effect.The results of the gut microbiome alteration by synthetic Nano-ZnO not only provide solution to exposure monitoring of environmental hazard, but rationalize their large-scale manufacture as alternative additive in the food chain.
- Published
- 2023
29. Emergent swarming states in active particles system with opposite anisotropic interactions
- Author
-
Yong-liang Gou, Zhonghuai Hou, and Huijun Jiang
- Subjects
Physics ,Active particles ,Swarming (honey bee) ,Janus particles ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Suspension (chemistry) ,Chemical physics ,Phase (matter) ,Particle ,Physical and Theoretical Chemistry ,0210 nano-technology ,Anisotropy ,Langevin dynamics - Abstract
From the organization of animal flocks to the emergence of swarming behaviors in bacterial suspension, populations of motile organisms at all scales display coherent collective motion. Recent studies showed that the anisotropic interaction between active particles plays a key role in the phase behaviors. Here we investigate the collective behaviors of based-active Janus particles that experience an anisotropic interaction of which the orientation is opposite to the direction of active force by using Langevin dynamics simulations in two dimensional space. Interestingly, the system shows emergence of collective swarming states upon increasing the total area fraction of particles, which is not observed in systems without anisotropic interaction or activity. The threshold for emergence of swarming states decreases as particle activity or interaction strength increases. We have also performed basic kinetic analysis to reproduce the essential features of the simulation results. Our results demonstrate that anisotropic interactions at the individual level are sufficient to set homogeneous active particles into stable directed motion.
- Published
- 2020
30. A Kinetic View on Proximity-Dependent Selectivity of Carbon Dioxide Reduction on Bifunctional Catalysts
- Author
-
Zhonghuai Hou, Yi Luo, and Huijun Jiang
- Subjects
Chemistry ,Kinetics ,General Chemistry ,Photochemistry ,Kinetic energy ,Combinatorial chemistry ,Catalysis ,Bifunctional catalyst ,chemistry.chemical_compound ,Kinetic Monte Carlo ,Methanol ,Bifunctional ,Selectivity ,Electrochemical reduction of carbon dioxide - Abstract
Multifunctional catalysts with distinct functional components are known to have much improved selectivity. However, the well-known proximity-dependent selectivity observed in several high profile experiments is yet to be understood. Here, we reveal that such dependence is closely associated with the kinetics involved. Based on reaction-diffusion dynamics together with kinetic Monte Carlo simulation on a coarse-grained model, one famous example of bifunctional catalysis, namely the proximity-dependent selectivity from carbon dioxide to liquid fuels on a bifunctional catalyst composed of HZSM-5 and In2O3, has been systematically examined. It is found that the diffusion kinetics of the intermediate methanol generated on In2O3 plays a decisive role for the selectively. For different In2O3/HZSM-5 proximities, the local methanol concentration induce a shift of the dominant process for subsequent methanol-to-hydrocarbon reactions inside HZSM-5, resulting in a preferred reaction window to generate favorable liquid fuels with profound high selectivity. Our findings emphasize the importance of the largely overlooked kinetic in the design of multifunctional catalysts.
- Published
- 2020
31. Surface Engineering on Commercial Cu Foil for Steering C
- Author
-
Peiquan, Ling, Yinghuan, Liu, Zhiqiang, Wang, Li, Li, Jun, Hu, Junfa, Zhu, Wensheng, Yan, Huijun, Jiang, Zhonghuai, Hou, Yongfu, Sun, and Yi, Xie
- Abstract
Designing catalysts with high selectivity toward C
- Published
- 2022
32. Drug-loaded oleic-acid grafted mesoporous silica nanoparticles conjugated with α-lactalbumin resembling BAMLET-like anticancer agent with improved biocompatibility and therapeutic efficacy
- Author
-
Wei Pei, Ling Cai, Xing Gong, Li Zhang, Jiarong Zhang, Ping Zhu, Huijun Jiang, Chao Wang, Shoulin Wang, and Jin Chen
- Subjects
Biomaterials ,Biomedical Engineering ,Bioengineering ,Cell Biology ,Molecular Biology ,Biotechnology - Abstract
Despite its prominent therapeutic efficacy, chemotherapy has raised serious concerns due to the severe adverse effects and multidrug resistance evoked, which propels the search for safe and green therapeutic agents. BAMLET (bovine α-lactalbumin made lethal against tumor cell) is a well-known protein-based anticancer agent of selective tumoricidal activity. Here, we prepared oleic acid-modified mesoporous silica nanoparticles (OA-MSNs) conjugated with bovine α-lactalbumin, a lipoprotein complex resembling BAMLET formed on the surface of MSNs (MSN-BAMLET) to load the anticancer drug of docetaxel (DTX). Compared to that of OA-MSNs/DTX, the obtained MSN-BAMLET/DTX with a sustained and pH-responsive drug release behaviors exhibited good biocompatibility and enhanced cytotoxic effect against cancer cells. Moreover, the presence of lipoprotein complex in MSN-BAMLET contributed to the improved dispersion of the composite in solution and the inhibitory effect on the migration of cancer cells. Furthermore, the adsorption profiles of protein corona on the obtained nanoparticles were analyzed. It was found that the marked low amount and abundance of plasma proteins were adsorbed on the α-lactalbumin coated siliceous composite demonstrated its long circulation property. Finally
- Published
- 2022
33. Clinical Value of Early-pregnancy Glycated Hemoglobin, Fasting Plasma Glucose, and Body Mass Index in Screening Gestational Diabetes Mellitus
- Author
-
Yanqin Lou, Li Xiang, Xuemei Gao, and Huijun Jiang
- Subjects
Glycated Hemoglobin ,Blood Glucose ,Diabetes, Gestational ,endocrine system diseases ,Pregnancy ,Biochemistry (medical) ,Clinical Biochemistry ,Humans ,nutritional and metabolic diseases ,Female ,Fasting ,Prospective Studies ,Body Mass Index - Abstract
Objective To investigate clinical values of early-pregnancy (8–13 weeks) glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and body mass index (BMI) in screening gestational diabetes mellitus (GDM). Methods A total of 1120 cases underwent a 75 g oral glucose tolerance test (OGTT), of which 216 cases with GDM were selected as the study group, and 278 cases without GDM were selected as the control group. FPG, HbA1c, and BMI in early pregnancy were measured. The correlation between FPG, HbA1c and BMI in early pregnancy and the incidence of GDM was analyzed by binary logistic regression, and the value of each index in predicting GDM alone or in combination was evaluated. Results FPG, HbA1c, and BMI in early pregnancy in the GDM group were higher than those in the control group, and the differences were statistically significant (P < .05). Binary logistic regression analysis showed that FPG, HbA1c, and BMI were risk factors for GDM in early pregnancy (odds ratio [OR] values were 3.374 [P < .05], 4.644 [P < .001], and 1.077 [P < .001], respectively). The area under the receiver operating characteristic (ROC) curve of FPG, glycated hemoglobin, and BMI in screening GDM for early pregnancy were 0.647, 0.661, and 0.608, respectively, while the area under the ROC curve of the combination of these 3 indicators was 0.736. Conclusion We found that FPG, HbA1c, and BMI in early pregnancy might be the potential risk factors for the occurrence of GDM, and the combination of them had certain clinical predictive value for GDM. However, it is still necessary for more studies, especially prospective studies, to validate our findings in the future.
- Published
- 2022
34. Radial Nanowire Assemblies under Rotating Magnetic Field Enabled Efficient Charge Separation
- Author
-
Jin-Long Wang, Jian-Wei Liu, Shu-Hong Yu, Xi-Feng Ren, Huijun Jiang, Zhonghuai Hou, Rui Wang, Zhen He, Wei-Ran Huang, and Lan-Tian Feng
- Subjects
Fabrication ,Chemical substance ,Nanowire ,Electrons ,Bioengineering ,02 engineering and technology ,Electron ,General Materials Science ,Stochastic Processes ,Rotating magnetic field ,Nanowires ,business.industry ,Mechanical Engineering ,Energy conversion efficiency ,Electric Conductivity ,Equipment Design ,General Chemistry ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Magnetic field ,Magnetic Fields ,Semiconductor ,Semiconductors ,Optoelectronics ,0210 nano-technology ,business - Abstract
Developing efficient charge separation strategies is essential to achieve high-power conversion efficiency in the fields of chemistry, biology, and material science. Herein, we develop a facile strategy for fabrication of unique wafer-scale radial nanowire assemblies by exploiting shear force in rotary solution. The assembly mechanism can be well revealed by the large-scale stochastic dynamics simulation. Free electrons can be rapidly generated to produce quantitatively tunable current output when the radial nanowire assemblies rotate under the magnetic field. Moreover, the photoconductive performance of the radial semiconductor nanowire assemblies can be remarkably enhanced as the electron-hole recombination was retrained by the efficient charge separation under the rotating magnetic field. Such large-scale unique nanowire assemblies will facilitate the design of an efficient charge separation process in biosystem, sensors, and photocatalysis.
- Published
- 2020
35. A Sm(III) Coordination Polymer Containing 2,5-Furandicarboxylic Acid: Crystal Structure and Recognition of Oxalate in Water
- Author
-
J. Zhang, Zengli Zhang, Z.-Q. Wan, Huijun Jiang, Y. Yang, and Yichun Ju
- Subjects
010302 applied physics ,Aqueous solution ,Coordination polymer ,General Chemistry ,Food chemistry ,Crystal structure ,010403 inorganic & nuclear chemistry ,Condensed Matter Physics ,01 natural sciences ,Oxalate ,0104 chemical sciences ,chemistry.chemical_compound ,Ultraviolet visible spectroscopy ,chemistry ,0103 physical sciences ,Molecule ,General Materials Science ,2,5-Furandicarboxylic acid ,Nuclear chemistry - Abstract
The {[Sm2(FDC)2](FDC) · 10H2O}n complex, where H2FDC is a 2,5-furandicarboxylic acid, has been prepared by hydrothermal reaction and structurally characterized by X-ray single-crystal diffraction and elemental analyses. In the complex, each Sm3+ ion is nine-coordinated by four O atoms from two H2FDC ligands and five O atoms from five water molecules. Due to the crucial role of oxalate detection in food chemistry and clinical analysis, oxalate detecting properties were investigated in water by ultraviolet and visible spectroscopy. The results indicated that the complex is a potential candidate for oxalate detector in aqueous solution.
- Published
- 2020
36. Frontispiece: Local Field Induced Mass Transfer: New Insight into Nano‐electrocatalysis
- Author
-
Yinghuan Liu, Huijun Jiang, and Zhonghuai Hou
- Subjects
Organic Chemistry ,General Chemistry ,Catalysis - Published
- 2021
37. Water-Induced Chiral Separation on a Au(111) Surface
- Author
-
Yangfan Wu, Huijun Jiang, Mengxi Liu, Lina Shang, Xiaohui Qiu, Yuanqi Ding, Yinfu Liu, Donglin Li, Luye Sun, Lei Xie, Lifeng Chi, and Wei Xu
- Subjects
chemistry.chemical_classification ,Biomolecule ,General Engineering ,General Physics and Astronomy ,RNA ,Water ,Uracil ,Stereoisomerism ,Amino acid ,chemistry.chemical_compound ,chemistry ,Computational chemistry ,Cluster (physics) ,Molecule ,Nanotechnology ,General Materials Science ,Homochirality ,Amino Acids ,Chirality (chemistry) - Abstract
Facing the scientific question of the origin of chirality in life, water is considered to play a crucial role in driving many biologically relevant processes in vivo. Water has been demonstrated in vitro to be related to chiral generation, amplification, and inversion, while the underlying mechanism is still not fully understood. Real-space evidence at the single-molecule level is thus urgently required to understand the role of water molecules in biomolecular chirality related issues. Herein, we choose one of the RNA bases, the biomolecule uracil (U), which self-assembles into racemic hydrogen-bonded structures. Upon water exposure, surprisingly, racemic structures could be transformed to homochiral water-involved structures, resulting in an unexpected chiral separation on the surface. The origin of chiral separation is due to preferential binding between water and the specific site of U molecules, which leads to the formation of the energetically most favorable homochiral (U-H2O-U)2 cluster as seed for subsequent chiral amplification. Such a water-driven self-assembly process may also be extended to other biologically relevant systems such as amino acids and sugars, which would provide general insights into the role that water molecules may play in the origin of homochirality in vivo.
- Published
- 2021
38. Complications With Surgical Treatment of Pediatric Supracondylar Humerus Fractures: Does Surgeon Training Matter?
- Author
-
Mikaela H. Sullivan, Andrew T. Chen, Craig R. Louer, Alysa B. Nash, Matthew R. Stillwagon, Feng-Chang Lin, and Huijun Jiang
- Subjects
medicine.medical_specialty ,Humeral Fractures ,Multivariate analysis ,Referral ,Bone Nails ,Subspecialty ,Single Center ,medicine ,Humans ,Orthopedics and Sports Medicine ,Humerus ,Child ,Retrospective Studies ,business.industry ,General Medicine ,Odds ratio ,Perioperative ,Orthopedic Surgeons ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,business ,Cohort study - Abstract
INTRODUCTION National trends reveal increased transfers to referral hospitals for surgical management of pediatric supracondylar humerus (SCH) fractures. This is partly because of the belief that pediatric orthopaedic surgeons (POs) deliver improved outcomes compared with nonpediatric orthopaedic surgeons (NPOs). We compared early outcomes of surgically treated SCH fractures between POs and NPOs at a single center where both groups manage these fractures. METHODS Patients ages 3 to 10 undergoing surgery for SCH fractures from 2014 to 2020 were included. Patient demographics and perioperative details were recorded. Radiographs at surgery and short-term follow-up assessed reduction. Primary outcomes were major loss of reduction (MLOR) and iatrogenic nerve injury (INI). Complications were compared between PO-treated and NPO-treated cohorts. RESULTS Three hundred and eleven fractures were reviewed. POs managed 132 cases, and NPOs managed 179 cases. Rate of MLOR was 1.5% among POs and 2.2% among NPOs (P=1). Rate of INI was 0% among POs and 3.4% among NPOs (P=0.041). All nerve palsies resolved postoperatively by mean 13.1 weeks. Rates of reoperation, infection, readmission, and open reduction were not significantly different. Operative times were decreased among POs (38.1 vs. 44.6 min; P=0.030). Pin constructs were graded as higher quality in the PO group, with a higher mean pin spread ratio (P=0.029), lower rate of "C" constructs (only 1 "column" engaged; P=0.010) and less frequent crossed-pin technique (P
- Published
- 2021
39. Emergent spiral vortex of confined biased active particles
- Author
-
Deping Huang, Huijun Jiang, Zhonghuai Hou, and Yunfei Du
- Subjects
Physics ,Work (thermodynamics) ,Classical mechanics ,Spiral vortex ,Orientation (geometry) ,Active particles ,Boundary (topology) ,Concentric ,Anisotropy ,Vortex - Abstract
Confinement is known to have profound effects on the collective dynamics of many active systems. Here, we investigate a modeled active system in circular confinement consisting of biased active particles, where the direction of active force deviates a biased angle from the principle orientation of the anisotropic interaction. We find that such particles can spontaneously form a spiral vortex with two concentric and counter-rotating regions near the boundary. The emerged vortex can be measured by the vortex order parameter which shows nonmonotonic dependencies on both the biased angle and the strength of the anisotropic interaction. Our work can provide an understanding of such dynamic behaviors and enable different strategies for designing ordered collective behaviors.
- Published
- 2021
40. Self-assembled recombinant camel serum albumin nanoparticles-encapsulated hemin with peroxidase-like activity for colorimetric detection of hydrogen peroxide and glucose
- Author
-
Ling Cai, Xinyu Yu, Jin Chen, Jiarong Zhang, Qilan Xu, Wei Pei, and Huijun Jiang
- Subjects
Camelus ,Biocompatibility ,Serum albumin ,Biochemistry ,Horseradish peroxidase ,law.invention ,chemistry.chemical_compound ,Structural Biology ,law ,Biomimetics ,Limit of Detection ,Animals ,Hydrogen peroxide ,Molecular Biology ,Serum Albumin ,Peroxidase ,chemistry.chemical_classification ,Chromatography ,biology ,General Medicine ,Hydrogen Peroxide ,Recombinant Proteins ,Kinetics ,Enzyme ,Glucose ,chemistry ,Reagent ,biology.protein ,Recombinant DNA ,Hemin ,Nanoparticles ,Colorimetry - Abstract
The construction of enzyme mimics using protein protection layers possesses advantages of high biocompatibility and superior catalytic activity, which is desirable for biomedical applications including diseases diagnosis. Here, from E. coli expression system, recombinant protein of camel serum albumin (rCSA) from Camelus bactrianus was successfully obtained to encapsulate hemin via the self-assemble method without additional toxic organic reagents. As compared with that of horseradish peroxidase, the produced rCSA-hemin nanoparticles exhibited enhanced enzyme-mimicking activity and stability under harsh experimental conditions. Additionally, the steady-state kinetic analysis of rCSA-hemin in the solution revealed its higher affinity to the substrates. Therefore, a colorimetric detection method of H2O2 and glucose was constructed with a linear range of 2.5–500 μM with an LOD of 2.39 and 2.42 μM, respectively, which was also applied for the determination of glucose in the serum samples with satisfying recovery ratio ranging from 101.1% to 112.1%. The constructed camel protein-derived nanozyme system of remarkable stability holds promising potentials for the versatile biomedical uses.
- Published
- 2021
41. Abstract P113: Underestimation Of Sudden Death Due To Restrictive Sudden Cardiac Death Criteria
- Author
-
Huijun Jiang, Albert Chang, Golsa Joodi, Ross J. Simpson, Feng-Chang Lin, Sanjana Thota, Caroline Tybout, and Susan Keen
- Subjects
medicine.medical_specialty ,business.industry ,Physiology (medical) ,Incidence (epidemiology) ,Internal medicine ,Epidemiology ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business ,Sudden death ,Sudden cardiac death - Abstract
Background: Efforts to prevent sudden death may be hampered by restrictive case definitions impairing accurate estimates of incidence and risk factors of sudden death. Sudden cardiac death (SCD) definitions include requirements for presence of comorbid coronary artery disease (CAD) and various time criteria since onset of symptoms or when victims were last seen well. We compared prevalence of three SCD definitions within a registry of all-cause natural, sudden deaths. Hypothesis: We assessed the hypothesis that the restrictive criteria of three SCD definitions underestimate sudden death and exclude populations with increased medical comorbidities. Methods: Using a registry of 399 adjudicated sudden death cases among adults aged 18-64 in Wake County, North Carolina in 2013-2015, we included 271 cases after excluding for missing values, chronic kidney disease, or heart failure. Time since last seen alive was classified as less than one hour or 24 hours from scene reports. Presence of CAD and co-morbidities were defined from clinical or autopsy records. Prevalence of SCD using criteria defined by Atherosclerosis Risk in Communities (ARIC), the World Health Organization (WHO), and the Oregon Sudden Unexpected Death (SUD) registry were calculated. Prevalence of SCD risk factors were calculated for the 3 SCD subgroups and compared to the original 271 victims using two-sample t-test and Fisher’s exact test for continuous and categorical variables. Results: Among the 271 cases, criteria were met for the three SCD definitions for n (%): ARIC 28 (10%), WHO 54 (20%), and SUD 90 (33%) (Table 1). ARIC and WHO-defined SCD cases were younger than the original 271 cases. There were no significant differences in sociodemographic and clinical factors by any SCD group compared to the original 271 cases. Conclusion: Restrictive SCD definitions that require the presence of CAD or a specific time frame of identification of death underestimate the incidence of sudden death and hinder effective prevention efforts for sudden death.
- Published
- 2021
42. Tunable Sorting of Mesoscopic Chiral Structures by External Noise in Achiral Periodic Potentials
- Author
-
Jie Su, Huijun Jiang, and Zhonghuai Hou
- Subjects
Physics ,Mesoscopic physics ,High Energy Physics::Lattice ,Sorting ,FOS: Physical sciences ,Non-equilibrium thermodynamics ,Condensed Matter - Soft Condensed Matter ,External noise ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,General Energy ,Chemical physics ,Robustness (computer science) ,Path (graph theory) ,Thermal ,Soft Condensed Matter (cond-mat.soft) ,Physical and Theoretical Chemistry ,Chirality (chemistry) - Abstract
Efficient chirality sorting is now highly demanded to separate assembled mesoscopic chiral structures which are of very special physical properties rather than their achiral counterparts or those at the single-particle level. However, the efficiency of conventional methods usually suffers from the thermal or external noise. Here, we propose a mechanism utilizing external noise to attain a tunable sorting of mesoscopic chiral particles in an achiral periodic potential. The complete chirality-separation stems from the path selection by a noise-induced biased flux in a nonequilibrium landscape. Such mechanism provides a practicable way to control the motion of chiral particles by simply adjusting the noise intensity, which is demonstrated by simultaneous separation of several kinds of enantiomorphs with different degrees of chirality. The robustness and generalizability of noise-tuned chirality sorting is further verified in systems with other types of periodic potentials or spatially/temporally correlated noise., Comment: 7 figures
- Published
- 2019
43. Ordered Nanostructure Enhances Electrocatalytic Performance by Directional Micro-Electric Field
- Author
-
Zhen He, Huijun Jiang, Xi-Feng Ren, Jian-Wei Liu, Shu-Hong Yu, Zhonghuai Hou, Qing-Xia Chen, Xiao-Zhuo Qi, Ying-Huan Liu, and Jin-Long Wang
- Subjects
Nanostructure ,Chemistry ,Kinetics ,Nanotechnology ,General Chemistry ,Electrolyte ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Catalysis ,Nanomaterial-based catalyst ,0104 chemical sciences ,Colloid and Surface Chemistry ,Electric field ,Renewable energy system ,Molecule - Abstract
Designing high-efficiency catalyst is at the heart of a transition to future renewable energy systems. Great achievements have been made to optimize thermodynamics to reduce energetic barriers of the catalytic reactions. However, little attention has been paid to design catalysts to improve kinetics to enrich the local concentration of reactant molecules surrounding electrocatalysts. Here, we find that well-designed nanocatalysts with periodic structures can optimize kinetics to accelerate mass-transport from bulk electrolyte to the catalyst surface, leading to the enhanced catalytic performance. This achievement stems from regulation of the surface reactant flux due to the gradient of the microelectric field directing uniformly to the nearest catalyst on ordered pattern, so that all of the reactant molecules are utilized sufficiently for reactions, enabling the boost of the electrocatalytic performance. This novel concept is further confirmed in various catalytic systems and nanoassemblies, such as nanoparticles, nanorods, and nanoflakes.
- Published
- 2019
44. Two Rare-Earth Complexes (Sm, La) Based on a Carbon-Bridged Bis(phenolate): Synthesis and Crystal Structures
- Author
-
Liu Yuqing, Peng Chen, Yichun Ju, Huijun Jiang, B. Liu, Ke Wang, and X. M. Luo
- Subjects
Ionic radius ,Chemistry ,Ligand ,General Chemical Engineering ,chemistry.chemical_element ,Infrared spectroscopy ,General Chemistry ,Crystal structure ,010402 general chemistry ,010403 inorganic & nuclear chemistry ,01 natural sciences ,Toluene ,0104 chemical sciences ,Metal ,Crystallography ,chemistry.chemical_compound ,visual_art ,Yield (chemistry) ,visual_art.visual_art_medium ,Carbon - Abstract
Two rare earth metal complexes based on the carbon-bridged bis(phenolate) ligand, 2,2'-methylene-bis(6-tert-butyl-4-methyl-phenoxo) (LH2), have been synthesized. Reaction of LH2 with (C5H5)3Sm(THF) in a 1.5 : 1 molar ratio in THF at 50°C produced rare earth metal bis(phenolate) complex (C5H5)Sm(L)(THF)2 (I) in almost quantitative yields. Complex I reacted with 0.5 molar ratio of LH2 in toluene at 80°C afforded (L)Sm(LH)(THF)2 (II) as the final product in good yield. Reaction of LNa2 with LaCl3 in a 2 : 1 molar ratio in THF at room temperature produced hetero-nuclear rare earth metal bis(phenolate) complex (L)La(LH)(THF)2Na(THF)2 (III). In addition, II and III were characterized by X-ray single-crystal diffraction analysis (CIF file CCDC nos. 1500917 (II) and 1826699 (III)) as well as characterizations including elemental analyses and IR spectra of both complexes. Furthermore, detail reasons of the difference of structures are presented. The ionic radii of the rare earth metal plays a significant role in the structure difference of two complexes.
- Published
- 2019
45. Real-time cell analysis of the cytotoxicity of a pH-responsive drug-delivery matrix based on mesoporous silica materials functionalized with ferrocenecarboxylic acid
- Author
-
Luming Peng, Jin Chen, Ling Cai, Huijun Jiang, Yujie Wen, Yuan Wu, and Zhihui Xu
- Subjects
Time Factors ,Cell Survival ,Metallocenes ,Intracellular Space ,02 engineering and technology ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,Matrix (chemical analysis) ,medicine ,Humans ,Environmental Chemistry ,Molecule ,Doxorubicin ,Ferrous Compounds ,Cytotoxicity ,Spectroscopy ,Drug Carriers ,Chemistry ,010401 analytical chemistry ,Biological Transport ,Hydrogen-Ion Concentration ,Mesoporous silica ,Silicon Dioxide ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Drug Liberation ,Chemical engineering ,A549 Cells ,Drug delivery ,Amine gas treating ,Drug Screening Assays, Antitumor ,0210 nano-technology ,Mesoporous material ,Porosity ,HeLa Cells ,medicine.drug - Abstract
During the past decade, accumulating studies have been conducted on the mesoporous silica materials as the matrix of controlled drug-delivery, in which the complicated post-synthesis procedures are often involved with the molecular design to achieve the efficacy. In this study, a simplified drug delivery system of anti-cancer drug of doxorubicin (DOX) based on mesoporous SBA-15 functionalized with ferrocenecarboxylic acid (FCA) was constructed. Through a combination of physicochemical characterizations, the presence of FCA that was anchored inside the pore wall of amine groups grafted SBA-15 exhibits electron-accessible behavior without affecting the intactness of composite material. The pH-responsive release of drug molecules was achieved through the conjugation of DOX with FCA in the interior channels of mesoporous composites, which also favors the more coverage of DOX. Furthermore, the real-time cell analysis was performed to monitor the release of DOX from the mesopores and resulting cytotoxicity of cancer cell of A549 was evaluated, which results in a calculated IC50 of 43.8 μg/ml (24 h). The constructed mesoporous FCA-SBA-15 composite material provides an integrated nanoplatform to exert controlled-delivery of anti-cancer drug molecules.
- Published
- 2019
46. Assembled superlattice with dynamic chirality in a mixture of biased-active and passive particles
- Author
-
Huijun Jiang, Yong-liang Gou, and Zhonghuai Hou
- Subjects
Physics ,Range (particle radiation) ,Condensed matter physics ,Superlattice ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Active force ,Orientation (geometry) ,Particle ,0210 nano-technology ,Anisotropy ,Chirality (chemistry) ,Langevin dynamics - Abstract
We introduce a general model of biased-active particles (BAPs) with anisotropic interactions, where the direction of the active force has a nonzero biased angle from the principal orientation of the anisotropic interaction between particles, and investigate the self-assembly behaviors of a mixture of BAPs with passive particles by using Langevin dynamics simulations. Remarkably, a highly ordered superlattice consisting of small hexagonal clusters with dynamic chirality emerges within a proper range of active force, given that the biased angle is not too small. In addition, there exists an optimal level of particle activity, being dependent on the biased-angle, which is the most favorable for both the long-range order and global dynamic chirality of the system. Our results demonstrate that fascinating collective behaviors can be explored through a proper design of new active particle models.
- Published
- 2019
47. A Stacked Plasmonic Metamaterial with Strong Localized Electric Field Enables Highly Efficient Broadband Light‐Driven CO 2 Hydrogenation
- Author
-
Tianyi Shao, Xiaonong Wang, Hanxiao Dong, Shengkun Liu, Delong Duan, Yaping Li, Pin Song, Huijun Jiang, Zhonghuai Hou, Chao Gao, and Yujie Xiong
- Subjects
Mechanics of Materials ,Mechanical Engineering ,General Materials Science - Published
- 2022
48. Local concentration effect on nano-electrocatalytic CO2 reduction
- Author
-
Yinghuan Liu, Zhonghuai Hou, and Huijun Jiang
- Published
- 2022
49. Dissection of the antibacterial mechanism of zinc oxide nanoparticles with manipulable nanoscale morphologies
- Author
-
Xinyi, Zhu, Jun, Wang, Ling, Cai, Yuan, Wu, Minghui, Ji, Huijun, Jiang, and Jin, Chen
- Subjects
Environmental Engineering ,Biofilms ,Health, Toxicology and Mutagenesis ,Escherichia coli ,Nanoparticles ,Environmental Chemistry ,Microbial Sensitivity Tests ,Zinc Oxide ,Pollution ,Waste Management and Disposal ,Anti-Bacterial Agents - Abstract
Despite the extensive uses of ZnO nanoparticles as promising antimicrobial agents to tackle the severe microbial infections, the systematic antibacterial studies on ZnO nanoparticles with manipulable nanoscale morphologies at the genetic expression level remain ill-defined. In this study, via a controllable thermal decomposition, ZnO nanoparticles of different morphologies were facilely prepared. Additionally, the surface PEGylation of ZnO was conducted to obtain the nanoparticles of low biotoxicity. While all the prepared ZnO nanoparticles exhibited the significantly chemical activities, the pronounced antibacterial effect of obtained ZnO nanoparticles was also identified, in which the ultra-small ones (~5 nm) showed the best performance. Moreover, the antibacterial activities of ZnO nanoparticles were studied by bacterial nucleic acid leakage, alkaline phosphatase, biofilm and reactive oxygen species (ROS) assays. Furthermore, the transcriptome analysis of ZnO nanoparticles with different morphologies against Escherichia coli (E. coli) revealed the underlying antibacterial mechanism involved the signal transduction, material transport, energy metabolism and other biological processes. Therefore, the cost-effective preparation of ZnO nanoparticles with distinct morphological features provides insights for the development of application specific antibacterial agents.
- Published
- 2022
50. Desolvation-induced formation of recombinant camel serum albumin-based nanocomposite for glutathione colorimetric determination
- Author
-
Jiarong Zhang, Wei Pei, Qilan Xu, Huijun Jiang, and Jin Chen
- Subjects
Materials Chemistry ,Metals and Alloys ,Electrical and Electronic Engineering ,Condensed Matter Physics ,Instrumentation ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2022
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.