111 results on '"Hui, J"'
Search Results
2. LoRa System with IOT Technology for Smart Agriculture System
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Leslie. Edwin, Hui J. Lee, Pin. J. Ker, Md Z. Jamaludin, Mohd Anif Akhmal Abu Bakar, Ramlah Awang, and Farah A.M. Yusuf
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- 2022
3. Power Over Fiber for Phone Charging Application
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Eric P. P. Amin, Najwan. A. Noorazmin, Hui J. Lee, Pin. J. Ker, Md Z. Jamaludin, Ramlah Awang, and Farah A.M. Yusof
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- 2022
4. The Future PoF in Energy Industry
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Eric P. P. Amin, Hui J. Lee, Pin J. Ker, Md Z. Jamaludin, Ramlah Awang, and Farah A. M. Yusof
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- 2022
5. Past and current drug repurposing clinical trials to treat cognition in methamphetamine use: a scoping review of pharmacotherapy candidates
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Megan M. St. Peters, Chun Hui J. Park, Alyna Turner, Alexandre A. Guerin, and Jee Hyun Kim
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- 2023
6. Additional file 1 of Common genetic variants do not predict recurrent events in coronary heart disease patients
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Thompson, P. L., Hui, J., Beilby, J., Palmer, L. J., Watts, G. F., West, M. J., Kirby, A., Marschner, S., Simes, R. J., Sullivan, D. R., White, H. D., Stewart, R., and Tonkin, A. M.
- Abstract
Additional file 1: SNPs included in the custom designed Illumina Gold Gate array of 384 SNPs with minor allele frequency (MAF) > 1 plus additional SNPs included in the panel derived by Mega et al [8].
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- 2022
- Full Text
- View/download PDF
7. Method and device for annihilation of methicillin-resistant Staphylococcus aureus
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Cheng, J. X., Seleem, Mohamed N., Dong, P. T., Hui, J., Cheng, JX, Seleem, Mohamed, Dong, PT, and Hui, J
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biochemical phenomena, metabolism, and nutrition - Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) possesses array of strategies to evade antibiotics through mutational inactivation, hiding inside host immune cells or concealing inside the biofilm in a sessile form. We report a drug-free approach to eradicate MRSA through blue-light bleaching of staphyloxanthin ( STX ), an anti-oxidative carotenoid residing inside the cell membrane of S. aureus. The photobleaching process, uncovered through a transient absorption imaging study and quantitated by mass spectrometry, decomposes STX and sensitizes MRSA to reactive oxygen species attack. Consequently, photobleaching using low-level blue light exhibits high-level synergy when combined with low-concentration of hydrogen peroxide. Anti microbial effectiveness of this synergistic therapy is validated in MRSA culture, MRSA-infected macrophage cells, biofilm, and a mouse wound infection model. Collectively, these findings highlight broad applications of STX photo bleaching for MRSA-infected diseases.
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- 2021
8. Contralateral Hemispheric Cerebral Blood Flow Measured With Arterial Spin Labeling Can Predict Outcome in Acute Stroke
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Tudor G Jovin, Maarten G Lansberg, Michael P. Marks, Soren Christensen, Gregory W. Albers, Bart P Keogh, Jia Guo, Tie Liang, Michael Mlynash, Stephanie Kemp, Emma Adair, Irina Eyngorn, Huy M. Do, Greg Zaharchuk, Thoralf Thamm, Jarrett Rosenberg, and Hui J Chen
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Male ,medicine.medical_specialty ,Neuroimaging ,Perfusion scanning ,Article ,Brain Ischemia ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Modified Rankin Scale ,Interquartile range ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Prospective Studies ,Prospective cohort study ,Stroke ,Aged ,Advanced and Specialized Nursing ,medicine.diagnostic_test ,business.industry ,Brain ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Clinical trial ,Treatment Outcome ,Cerebral blood flow ,Cerebrovascular Circulation ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery - Abstract
Background and Purpose— Imaging is frequently used to select acute stroke patients for intra-arterial therapy. Quantitative cerebral blood flow can be measured noninvasively with arterial spin labeling magnetic resonance imaging. Cerebral blood flow levels in the contralateral (unaffected) hemisphere may affect capacity for collateral flow and patient outcome. The goal of this study was to determine whether higher contralateral cerebral blood flow (cCBF) in acute stroke identifies patients with better 90-day functional outcome. Methods— Patients were part of the prospective, multicenter iCAS study (Imaging Collaterals in Acute Stroke) between 2013 and 2017. Consecutive patients were enrolled after being diagnosed with anterior circulation acute ischemic stroke. Inclusion criteria were ischemic anterior circulation stroke, baseline National Institutes of Health Stroke Scale score ≥1, prestroke modified Rankin Scale score ≤2, onset-to-imaging time Results— Seventy-seven patients (41 women) met the inclusion criteria with median (interquartile range) age of 66 (55–76) yrs, onset-to-imaging time of 4.8 (3.6–7.7) hours, and baseline National Institutes of Health Stroke Scale score of 13 (9–20). Median cCBF was 38.9 (31.2–44.5) mL per 100 g/min. Higher cCBF predicted good outcome at day 90 (odds ratio, 4.6 [95% CI, 1.4–14.7]; P =0.01), after controlling for baseline National Institutes of Health Stroke Scale, diffusion-weighted imaging lesion volume, and intra-arterial therapy. Conclusions— Higher quantitative cCBF at baseline is a significant predictor of good neurological outcome at day 90. cCBF levels may inform decisions regarding stroke triage, treatment of acute stroke, and general outcome prognosis. Clinical Trial Registration— URL: https://www.clinicaltrials.gov . Unique identifier: NCT02225730.
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- 2019
9. Spatiotemporal mapping of gene expression landscapes and developmental trajectories during zebrafish embryogenesis
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A. Chen, Shuo Wang, Xiaoshan Shi, Ma K, Liu S, Zhiqiang Dong, Liu L, Liu Q, Berberoglu Ma, Xueqiang Lin, Yeyang Ma, Li Y, Li R, Hui J, Yang X, Kai-Hong Zhao, Esteban Ma, Sahu Sk, Bao W, Fan G, Liu C, Xun Xu, Hao Wang, and Pei C
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Transcriptome ,Cell type ,Crosstalk (biology) ,Period (gene) ,Notch signaling pathway ,Embryo ,Computational biology ,Biology ,Cell fate determination ,biology.organism_classification ,Zebrafish - Abstract
SUMMARYVertebrate embryogenesis is a remarkably dynamic process during which numerous cell types of different lineages generate, change, or disappear within a short period of time. A major challenge in understanding this process is the lack of topographical transcriptomic information that can help correlate microenvironmental cues within the hierarchy of cell fate decisions. Here, we employed Stereo-seq, a high-definition spatially resolved transcriptomic technology, to dissect the spatiotemporal dynamics of gene expression and regulatory networks in the developing zebrafish embryos. We profiled 91 embryo sections covering six critical time points during the first 24 hours of development, obtaining a total of 139,391 spots at cellular size (∼100 μm2) with spatial coordinates. Meanwhile, we identified spatial modules and co-varying genes for specific tissue organizations. By performing the integrative analysis of the Stereo-seq and scRNA-seq data from each time point, we reconstructed the spatially resolved developmental trajectories of cell fate transitions and molecular changes during zebrafish embryogenesis. We further investigated the spatial distribution of ligand-receptor pairs for major signaling pathways and identified novel interactions that potentially crosstalk with the Notch signaling pathway during zebrafish development. Our study constitutes a fundamental reference for further studies aiming to understand vertebrate development.
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- 2021
10. Structural, mechanical and thermal properties of Ti1-xSixN/CrAlN (x = 0, 0.13 and 0.22) multilayers
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Chun Hu, Yu X. Xu, H. Wang, Li Chen, Yong Du, and Hui J. Liu
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Materials science ,Annealing (metallurgy) ,Mechanical Engineering ,Thermal decomposition ,Metals and Alloys ,Oxide ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,Thermal ,Materials Chemistry ,Composite material ,0210 nano-technology ,Oxidation resistance - Abstract
Nanoscaled Ti1-xSixN/CrAlN multilayers combining the cutting edges of Ti1-xSixN and CrAlN coatings are currently the focus of attention of researchers. Here, the structural, mechanical, and thermal properties of Ti1-xSixN/CrAlN multilayers with varied Si content were investigated. The hardness values of Ti1-xSixN/CrAlN multilayers are individually enhanced to 30.7 ± 1.0 GPa for x = 0, 36.0 ± 1.3 GPa for x = 0.13, and 35.9 ± 1.5 GPa for x = 0.22 from the 27.4 ± 0.3 GPa for CrAlN due to interfacial strengthening effect. Ti1-xSixN insertion layers retard the thermal decomposition process of CrAlN. After annealing at 1200 °C, the hardness of Ti1-xSixN/CrAlN (x = 0, 0.13, 0.22) multilayers is individually enhanced by ∼6.9, 12.9 and 13.6 GPa from the 18.7 ± 1.1 GPa for Cr0.32Al0.68N. However, Ti1-xSixN insertion layers lead to a drop in the oxidation resistance of CrAlN coatings due to their inferior oxidation resistance. Noticeable is that increasing Si content of Ti1-xSixN/CrAlN multilayers causes a decline in the thickness of oxide scales.
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- 2019
11. Context fear learning and renewal of extinguished fear are dissociated in juvenile female rats
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Chun Hui J. Park, Jee Hyun Kim, and Despina E. Ganella
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medicine.medical_specialty ,Context (language use) ,Audiology ,Affect (psychology) ,Extinction, Psychological ,Rats, Sprague-Dawley ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Developmental Neuroscience ,Conditioning, Psychological ,Developmental and Educational Psychology ,medicine ,Animals ,Juvenile ,0501 psychology and cognitive sciences ,Fear conditioning ,Behavior, Animal ,Recall ,05 social sciences ,Age Factors ,Fear ,Extinction (psychology) ,Rats ,Facilitation ,Conditioning ,Female ,Cues ,Psychology ,030217 neurology & neurosurgery ,050104 developmental & child psychology ,Developmental Biology - Abstract
Extinction is the decrease in emotion to a cue that was previously associated with an emotionally significant event. It involves repeated presentation of the cue without any consequences. In adult animals, extinguished fear to a cue can return if the cue is presented in a different environment/context to where extinction occurred, referred to as renewal. We have previously reported that developing female, but not male, rats show renewal. This study investigates whether the ability of developing female rats to show renewal is related to their ability in fear conditioning to the context. Additionally, facilitation of context conditioning by weaning previously shown in male rats was tested in developing female rats. In experiment 1, postnatal day 25 (P25) and P18 female rats showed renewal. P25 rats show more fear overall, suggesting a weaker extinction recall in this age. Experiment 2 tested context- and cue-elicited fear either immediately or 24 hr following conditioning. At the immediate test, P18 rats showed less context-fear compared with P25 rats. All rats showed low levels of context-fear at the 24 hr test. There were no age differences in cued fear. Weaning at P21 did not affect context or cue memory in P25 female rats. These findings suggest that the ability to form contextual fear memory is unrelated to the expression of renewal in juvenile female rats.
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- 2019
12. Improved properties of TiAlN coating by combined Si-addition and multilayer architecture
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Hui J. Liu, Fei Pei, Li Chen, Yu X. Xu, and Yong Du
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Nanocomposite ,Materials science ,Annealing (metallurgy) ,Spinodal decomposition ,Mechanical Engineering ,Metals and Alloys ,Oxide ,02 engineering and technology ,engineering.material ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Nanocrystalline material ,0104 chemical sciences ,Amorphous solid ,chemistry.chemical_compound ,Coating ,chemistry ,Mechanics of Materials ,Materials Chemistry ,engineering ,Composite material ,0210 nano-technology ,Wurtzite crystal structure - Abstract
Alloying a fourth element and multilayer architecture are efficient methods to tailor the structure and properties of aluminum-containing transition metal nitrides coatings. Here, we combine Si-addition and multilayer structure to improve the properties of TiAlN coating. Incorporation of Si into TiAlN leads to a nanocomposite structure with TiAlN nanocrystalline encapsulated by amorphous SiNx, and thereby an increased hardness from 29.1 ± 1.0 GPa for Ti0.52Al0.48N to 33.1 ± 1.2 GPa for Ti0.53Al0.38Si0.09N. In order to avoid the formation of undesired wurtzite (w) AlN in Ti0.53Al0.38Si0.09N, the c-Ti0.52Al0.48N template layer (∼5.2 nm) is used to stabilize Ti0.53Al0.38Si0.09N layer (∼7.5 nm) in its metastable cubic structure based on epitaxial growth. The Ti0.52Al0.48N/Ti0.53Al0.38Si0.09N multilayer with an overall cubic structure shows a hardness value of 35.6 ± 0.7 GPa. All coatings exhibit an age-hardening ability due to the spinodal decomposition. A peak hardness value of 36.7 ± 0.8 and 38.2 ± 0.5 GPa is achieved by Ti0.53Al0.38Si0.09N and Ti0.52Al0.48N/Ti0.53Al0.38Si0.09N, respectively, upon annealing at 1000 °C. In contrast, Ti0.52Al0.48N coating exhibits a maximum hardness increase to 33.5 ± 0.8 GPa at 800 °C. Furthermore, the Ti0.53Al0.38Si0.09N and Ti0.52Al0.48N/Ti0.53Al0.38Si0.09N coatings show oxide scales of ∼2.1 and 1.0 μm at 1000 °C for 10 h after exposure to air atmosphere, respectively, whereas the Ti0.52Al0.48N coating has already been completely oxidized at 850 °C.
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- 2019
13. Gene cloning and characterization of an organic solvent-stimulated β-glucosidase and its application for the co-production of ethanol and succinic acid
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Cui Y. Liang, Yu Zhang, Zhen H. Yuan, Hui J. Xu, Wen Luo, Wei Qi, Jing L. Xu, Xiao Y. Chen, and Zhong M. Wang
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Chromatography ,Ethanol ,Polymers and Plastics ,biology ,Bioconversion ,Chemistry ,Substrate (chemistry) ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,biology.organism_classification ,01 natural sciences ,Hydrolysate ,0104 chemical sciences ,Pichia pastoris ,Hydrolysis ,chemistry.chemical_compound ,Succinic acid ,0210 nano-technology ,Bagasse - Abstract
Enzymatic activity is a limiting factor for conducting the hydrolysis of lignocellulosic waste materials to generate renewable biofuels and biochemicals. A novel β-glucosidase (BGL) gene from Hypocrea sp. W63 was cloned and expressed in Pichia pastoris. The specific activity of the purified recombinant epB-BGL was 194.25 IU/mg using p-nitrophenyl-β-d-glucoside (pNPG) as a substrate. The optimum pH and temperature for epB-BGL were 5.0 and 70 °C, respectively. The activity of recombinant epB-BGL could be stimulated by 210% with the addition of 10% (v/v) ethanol. Furthermore, other organic solvents were also able to stimulate the activity of the enzyme at concentrations of 1% or 10% (v/v). Due to this distinctive performance, epB-BGL was used to release fermentable sugars from a sugarcane bagasse hydrolysate for ethanol and succinic acid co-production. In the experimental range, succinic acid was reached to 13.3 g/L with a higher yield of 0.91 g/g glucose and the ethanol was at a concentration of approximately 1.41 g/L, respectively. In addition, the by-product acetate, which could potentially be converted to other chemicals, was also produced at 9.745 g/L. This work demonstrates that recombinant epB-BGL can take advantage of incomplete hydrolysis to convert fermentable sugars, suggesting its potential application in lignocellulose bioconversion. Lignocellulose of sugarcane bagassese was hydrolysed to release fermentable sugars which with addition of epB-BGL for the co-production of ethanol and succinic acid.
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- 2019
14. Combined Alkylating Agents as a Resolution for Highly Selective N-Alkylation of 2-Hydroxybenzaldehyde Acylhydrazones
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Xin J. Cheng, Long F. Jin, La M. Wu, Hui J. Zhang, Xin Y. Zhao, and Qiao Y. Zhang
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chemistry.chemical_classification ,Resolution (mass spectrometry) ,010405 organic chemistry ,Organic Chemistry ,Alkyl bromide ,Regioselectivity ,Alkylation ,2-hydroxybenzaldehyde ,010402 general chemistry ,Highly selective ,01 natural sciences ,Combinatorial chemistry ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Salicylaldehyde ,lipids (amino acids, peptides, and proteins) ,Alkyl - Abstract
Although 2-hydroxybenzaldehyde acylhydrazones, such as salicylaldehyde acylhydrazones, are intriguing bioactive molecules, few of their N-alkylated derivatives are known, and only methyl analogues have been reported previously. We achieved selective N-alkylation of 2-hydroxybenzaldehyde acylhydrazones, as their Fe(III) complexes, by using combinations of alkylating agents (for example, an alkyl bromide and a dialkyl sulfate). Fifteen substrates were examined, and 45 new 2-hydroxybenzaldehyde acyl(alkyl)hydrazones were synthesized in moderate to good yields. In all cases, the target products were obtained exclusively, and no O-alkylation byproducts were produced. The method provides an efficient way of preparing 2-hydroxybenzaldehyde acyl(alkyl)hydrazones.
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- 2019
15. Osteomyelitis associated with Bartonella henselae infection in a young cat
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Rademacher, N., Breitschwerdt, E.B., Neupane, P., Ryan, K.A., and Hui, J.
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Small Animals - Abstract
Case summary A 1-year-old male intact domestic shorthair cat was evaluated for acute onset non-weightbearing left forelimb lameness and generalized peripheral lymphadenopathy. CT identified a monostotic aggressive bone lesion with an incomplete fracture of the left radial metaphysis. Bone aspirates yielded osteoblasts with minimal nuclear atypia. Abdominal ultrasound revealed a nodular spleen and lymphadenopathy; cytologically, both contained lymphoid hyperplasia. A urine histoplasma antigen test was negative. Bartonella henselae and Mycoplasma haemominutum DNA was amplified by PCR from peripheral blood. Indirect immunofluorescence documented strong B henselae immunoreactivity, with lower Bartonella vinsonii subspecies berkhoffii and Bartonella koehlerae antibody titers. After the administration of doxycycline and pradofloxacin for suspected Bartonella-induced osteomyelitis, lameness resolved rapidly. Six-week post-treatment radiographs identified healing of the affected bone, and Bartonella species enrichment blood culture was negative. B henselae antibody titers decreased four-fold over a year, supporting seroreversion. Relevance and novel information B henselae is a flea-transmitted, host-adapted species, not previously implicated as a cause of osteomyelitis in cats. B henselae subclinical bacteremia is highly prevalent among cats; however, bacteremia has been associated with lymphadenopathy and febrile illness in cats. This report describes a unique clinical presentation in association with B henselae infection in a cat.
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- 2022
16. Optimization of the JUNO liquid scintillator composition using a Daya Bay antineutrino detector
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Bay, Daya, collaborations, JUNO, Abusleme, A., Adam, T., Ahmad, S., Aiello, S., Akram, M., Ali, N., An, F. P., An, G. P., An, Q., Andronico, G., Anfimov, N., Antonelli, V., Antoshkina, T., Asavapibhop, B., de André, J. P. A. M., Babic, A., Balantekin, A. B., Baldini, W., Baldoncini, M., Band, H. R., Barresi, A., Baussan, E., Bellato, M., Bernieri, E., Biare, D., Birkenfeld, T., Bishai, M., Blin, S., Blum, D., Blyth, S., Bordereau, C., Brigatti, A., Brugnera, R., Budano, A., Burgbacher, P., Buscemi, M., Bussino, S., Busto, J., Butorov, I., Cabrera, A., Cai, H., Cai, X., Cai, Y. K., Cai, Z. Y., Cammi, A., Campeny, A., Cao, C. Y., Cao, G. F., Cao, J., Caruso, R., Cerna, C., Chakaberia, I., Chang, J. F., Chang, Y., Chen, H. S., Chen, P. A., Chen, P. P., Chen, S. M., Chen, S. J., Chen, X. R., Chen, Y. W., Chen, Y. X., Chen, Y., Chen, Z., Cheng, J., Cheng, Y. P., Cheng, Z. K., Chepurnov, A., Cherwinka, J. J., Chiarello, F., Chiesa, D., Chimenti, P., Chu, M. C., Chukanov, A., Chuvashova, A., Clementi, ., Clerbaux, B., Di Lorenzo, S. Conforti, Corti, D., Costa, S., Corso, F. D., Cummings, J. P., Dalager, O., De La Taille, C., Deng, F. S., Deng, J. W., Deng, Z., Deng, Z. Y., Depnering, W., Diaz, M., Ding, X. F., Ding, Y. Y., Dirgantara, B., Dmitrievsky, S., Diwan, M. V., Dohnal, T., Donchenko, G., Dong, J. M., Dornic, D., Doroshkevich, E., Dove, J., Dracos, M., Druillole, F., Du, S. X., Dusini, S., Dvorak, M., Dwyer, D. A., Enqvist, T., Enzmann, H., Fabbri, A., Fajt, L., Fan, D. H., Fan, L., Fang, C., Fang, J., Fatkina, A., Fedoseev, D., Fekete, V., Feng, L. C., Feng, Q. C., Fiorentini, G., Ford, R., Formozov, A., Fournier, A., Franke, S., Gallo, J. P., Gan, H. N., Gao, F., Garfagnini, A., Göttel, A., Genster, C., Giammarchi, M., Giaz, A., Giudice, N., Giuliani, F., Gonchar, M., Gong, G. H., Gong, H., Gorchakov, O., Gornushkin, Y., Grassi, M., Grewing, C., Gromov, M., Gromov, V., Gu, M. H., Gu, W. Q., Gu, X. F., Gu, Y., Guan, M. Y., Guardone, N., Gul, M., Guo, C., Guo, J. Y., Guo, L., Guo, W. L., Guo, X. H., Guo, Y. H., Guo, Z., Haacke, M., Hackenburg, R. W., Hackspacher, P., Hagner, C., Han, R., Han, Y., Hans, S., He, M., He, W., Heeger, K. M., Heinz, T., Heng, Y. K., Herrera, R., Higuera, A., Hong, D. J., Hor, Y. K., Hou, S. J., Hsiung, Y. B., Hu, B. Z., Hu, H., Hu, J. R., Hu, J., Hu, S. Y., Hu, T., Hu, Z. J., Huang, C. H., Huang, G. H., Huang, H. X., Huang, Q. H., Huang, W. H., Huang, X. T., Huang, Y. B., Huber, P., Hui, J. Q., Huo, L., Huo, W. J., Huss, C., Hussain, S., Insolia, A., Ioannisian, A., Ioannisyan, D., Isocrate, R., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Ji, X. Z., Jia, H. H., Jia, J. J., Jian, S. Y., Jiang, D., Jiang, X. S., Jin, R. Y., Jing, X. P., Johnson, R. A., Jollet, C., Jones, D., Joutsenvaara, J., Jungthawan, S., Kalousis, L., Kampmann, P., Kang, L., Karagounis, M., Kazarian, N., Kettell, S. H., Khan, A., Khan, W., Khosonthongkee, K., Kinz, P., Kohn, S., Korablev, D., Kouzakov, K., Kramer, M., Krasnoperov, A., Krokhaleva, S., Krumshteyn, Z., Kruth, A., Kutovskiy, N., Kuusiniemi, P., Lachacinski, B., Lachenmaier, T., Langford, T. J., Lee, J., Lee, J. H. C., Lefevre, F., Lei, L., Lei, R., Leitner, R., Leung, J., Li, C., Li, D. M., Li, F., Li, H. T., Li, H. L., Li, J., Li, J. J., Li, J. Q., Li, K. J., Li, M. Z., Li, N., Li, Q. J., Li, R. H., Li, S. C., Li, S. F., Li, S. J., Li, T., Li, W. D., Li, W. G., Li, X. M., Li, X. N., Li, X. L., Li, X. Q., Li, Y., Li, Y. F., Li, Z. B., Li, Z. Y., Liang, H., Liang, J. J., Liebau, D., Limphirat, A., Limpijumnong, S., Lin, C. J., Lin, G. L., Lin, S. X., Lin, T., Lin, Y. H., Ling, J. J., Link, J. M., Lippi, I., Littenberg, L., Littlejohn, B. R., Liu, F., Liu, H., Liu, H. B., Liu, H. D., Liu, H. J., Liu, H. T., Liu, J. C., Liu, J. L., Liu, M., Liu, Q., Liu, R. X., Liu, S. Y., Liu, S. B., Liu, S. L., Liu, X. W., Liu, Y., Lokhov, A., Lombardi, P., Loo, K., Lorenz, S., Lu, C., Lu, H. Q., Lu, J. B., Lu, J. G., Lu, S. X., Lu, X. X., Lubsandorzhiev, B., Lubsandorzhiev, S., Ludhova, L., Luk, K. B., Luo, F. J., Luo, G., Luo, P. W., Luo, S., Luo, W. M., Lyashuk, V., Ma, Q. M., Ma, S., Ma, X. B., Ma, X. Y., Ma, Y. Q., Malyshkin, Y., Mantovani, F., Mao, Y. J., Mari, S. M., Marini, F., Marium, S., Marshall, C., Martellini, C., Martin-Chassard, G., Caicedo, D. A. Martinez, Martini, A., Martino, J., Mayilyan, D., McDonald, K. T., McKeown, R. D., Müller, A., Meng, G., Meng, Y., Meregaglia, A., Meroni, E., Meyhöfer, D., Mezzetto, M., Miller, J., Miramonti, L., Monforte, S., Montini, P., Montuschi, M., Morozov, N., Muralidharan, P., Napolitano, J., Nastasi, M., Naumov, D. V., Naumova, E., Nemchenok, I., Nikolaev, A., Ning, F. P., Ning, Z., Nunokawa, H., Oberauer, L., Ochoa-Ricoux, J. P., Olshevskiy, A., Ortica, F., Pan, H. R., Paoloni, A., Park, J., Parkalian, N., Parmeggiano, S., Patton, S., Payupol, T., Pec, V., Pedretti, D., Pei, Y. T., Pelliccia, N., Peng, A. G., Peng, H. P., Peng, J. C., Perrot, F., Petitjean, P. A., Rico, L. F. Pineres, Popov, A., Poussot, P., Pratumwan, W., Previtali, E., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, S., Qian, X., Qian, X. H., Qiao, H., Qin, Z. H., Qiu, S. K., Rajput, M., Ranucci, G., Raper, N., Re, A., Rebber, H., Rebii, A., Ren, B., Ren, J., Reveco, C. M., Rezinko, T., Ricci, B., Robens, M., Roche, M., Rodphai, N., Rohwer, L., Romani, A., Rosero, R., Roskovec, B., Roth, C., Ruan, X. C., Ruan, X. D., Rujirawat, S., Rybnikov, A., Sadovsky, A., Saggese, P., Salamanna, G., Sangka, A., Sanguansak, N., Sawangwit, U., Sawatzki, J., Sawy, F., Schever, M., Schuler, J., Schwab, C., Schweizer, K., Selivanov, D., Selyunin, A., Serafini, A., Settanta, G., Settimo, M., Shahzad, M., Shi, G., Shi, J. Y., Shi, Y. J., Shutov, V., Sidorenkov, A., Simkovic, F., Sirignano, C., Siripak, J., Sisti, M., Slupecki, M., Smirnov, M., Smirnov, O., Sogo-Bezerra, T., Songwadhana, J., Soonthornthum, B., Sotnikov, A., Sramek, O., Sreethawong, W., Stahl, A., Stanco, L., Stankevich, K., Stefanik, D., Steiger, H., Steiner, H., Steinmann, J., Stender, M., Strati, V., Studenikin, A., Sun, G. X., Sun, L. T., Sun, J. L., Sun, S. F., Sun, X. L., Sun, Y. J., Sun, Y. Z., Suwonjandee, N., Szelezniak, M., Tang, J., Tang, Q., Tang, X., Tietzsch, A., Tkachev, I., Tmej, T., Treskov, K., Troni, G., Trzaska, W., Tse, W. -H., Tull, C. E., Tuve, C., van Waasen, S., Boom, J. Vanden, Vassilopoulos, N., Vedin, V., Verde, G., Vialkov, M., Viaud, B., Viren, B., Volpe, C., Vorobel, V., Votano, L., Walker, P., Wang, C., Wang, C. H., Wang, E., Wang, G. L., Wang, J., Wang, K. Y., Wang, L., Wang, M. F., Wang, M., Wang, N. Y., Wang, R. G., Wang, S. G., Wang, W., Wang, W. S., Wang, X., Wang, X. Y., Wang, Y., Wang, Y. F., Wang, Y. G., Wang, Y. M., Wang, Y. Q., Wang, Z., Wang, Z. M., Wang, Z. Y., Watcharangkool, A., Wei, H. Y., Wei, L. H., Wei, W., Wei, Y. D., Wen, L. J., Whisnant, K., White, C. G., Wiebusch, C., Wong, S. C. F., Wong, H. L. H., Wonsak, B., Worcester, E., Wu, C. H., Wu, D. R., Wu, F. L., Wu, Q., Wu, W. J., Wu, Z., Wurm, M., Wurtz, J., Wysotzki, C., Xi, Y. F., Xia, D. M., Xie, Y. G., Xie, Z. Q., Xing, Z. Z., Xu, D. L., Xu, F. R., Xu, H. K., Xu, J. L., Xu, J., Xu, M. H., Xu, T., Xu, Y., Xue, T., Yan, B. J., Yan, X. B., Yan, Y. P., Yang, A. B., Yang, C. G., Yang, H., Yang, J., Yang, L., Yang, X. Y., Yang, Y. F., Yang, Y. Z., Yao, H. F., Yasin, Z., Ye, J. X., Ye, M., Yegin, U., Yeh, M., Yermia, F., Yi, P. H., You, Z. Y., Young, B. L., Yu, B. X., Yu, C. X., Yu, C. Y., Yu, H. Z., Yu, M., Yu, X. H., Yu, Z. Y., Yuan, C. Z., Yuan, Y., Yuan, Z. X., Yuan, Z. Y., Yue, B. B., Zafar, N., Zambanini, A., Zeng, P., Zeng, S., Zeng, T. X., Zeng, Y. D., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, G. Q., Zhang, H. H., Zhang, H. Q., Zhang, J., Zhang, J. B., Zhang, J. W., Zhang, P., Zhang, Q. M., Zhang, T., Zhang, X. M., Zhang, X. T., Zhang, Y., Zhang, Y. H., Zhang, Y. M., Zhang, Y. P., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, F. Y., Zhao, J., Zhao, R., Zhao, S. J., Zhao, T. C., Zheng, D. Q., Zheng, H., Zheng, M. S., Zheng, Y. H., Zhong, W. R., Zhou, J., Zhou, L., Zhou, N., Zhou, S., Zhou, X., Zhu, J., Zhu, K. J., Zhuang, H. L., Zong, L., Zou, J. H., Abusleme A., Adam T., Ahmad S., Aiello S., Akram M., Ali N., An F.P., An G.P., An Q., Andronico G., Anfimov N., Antonelli V., Antoshkina T., Asavapibhop B., de Andre J.P.A.M., Babic A., Balantekin A.B., Baldini W., Baldoncini M., Band H.R., Barresi A., Baussan E., Bellato M., Bernieri E., Biare D., Birkenfeld T., Bishai M., Blin S., Blum D., Blyth S., Bordereau C., Brigatti A., Brugnera R., Budano A., Burgbacher P., Buscemi M., Bussino S., Busto J., Butorov I., Cabrera A., Cai H., Cai X., Cai Y.K., Cai Z.Y., Cammi A., Campeny A., Cao C.Y., Cao G.F., Cao J., Caruso R., Cerna C., Chang J.F., Chang Y., Chen H.S., Chen P.A., Chen P.P., Chen S.M., Chen S.J., Chen X.R., Chen Y.W., Chen Y.X., Chen Y., Chen Z., Cheng J., Cheng Y.P., Cheng Z.K., Chepurnov A., Cherwinka J.J., Chiarello F., Chiesa D., Chimenti P., Chu M.C., Chukanov A., Chuvashova A., Clementi C., Clerbaux B., Di Lorenzo S.C., Corti D., Costa S., Dal Corso F., Cummings J.P., Dalager O., De La Taille C., Deng F.S., Deng J.W., Deng Z., Deng Z.Y., Depnering W., Diaz M., Ding X.F., Ding Y.Y., Dirgantara B., Dmitrievsky S., Diwan M.V., Dohnal T., Donchenko G., Dong J.M., Dornic D., Doroshkevich E., Dove J., Dracos M., Druillole F., Du S.X., Dusini S., Dvorak M., Dwyer D.A., Enqvist T., Enzmann H., Fabbri A., Fajt L., Fan D.H., Fan L., Fang C., Fang J., Fatkina A., Fedoseev D., Fekete V., Feng L.C., Feng Q.C., Fiorentini G., Ford R., Formozov A., Fournier A., Franke S., Gallo J.P., Gan H.N., Gao F., Garfagnini A., Gottel A., Genster C., Giammarchi M., Giaz A., Giudice N., Giuliani F., Gonchar M., Gong G.H., Gong H., Gorchakov O., Gornushkin Y., Grassi M., Grewing C., Gromov M., Gromov V., Gu M.H., Gu W.Q., Gu X.F., Gu Y., Guan M.Y., Guardone N., Gul M., Guo C., Guo J.Y., Guo L., Guo W.L., Guo X.H., Guo Y.H., Guo Z., Haacke M., Hackenburg R.W., Hackspacher P., Hagner C., Han R., Han Y., Hans S., He M., He W., Heeger K.M., Heinz T., Heng Y.K., Herrera R., Higuera A., Hong D.J., Hor Y.K., Hou S.J., Hsiung Y.B., Hu B.Z., Hu H., Hu J.R., Hu J., Hu S.Y., Hu T., Hu Z.J., Huang C.H., Huang G.H., Huang H.X., Huang Q.H., Huang W.H., Huang X.T., Huang Y.B., Huber P., Hui J.Q., Huo L., Huo W.J., Huss C., Hussain S., Insolia A., Ioannisian A., Ioannisyan D., Isocrate R., Jaffe D.E., Jen K.L., Ji X.L., Ji X.P., Ji X.Z., Jia H.H., Jia J.J., Jian S.Y., Jiang D., Jiang X.S., Jin R.Y., Jing X.P., Johnson R.A., Jollet C., Jones D., Joutsenvaara J., Jungthawan S., Kalousis L., Kampmann P., Kang L., Karagounis M., Kazarian N., Kettell S.H., Khan A., Khan W., Khosonthongkee K., Kinz P., Kohn S., Korablev D., Kouzakov K., Kramer M., Krasnoperov A., Krokhaleva S., Krumshteyn Z., Kruth A., Kutovskiy N., Kuusiniemi P., Lachacinski B., Lachenmaier T., Landini C., Langford T.J., Lee J., Lee J.H.C., Lefevre F., Lei L., Lei R., Leitner R., Leung J., Li D.M., Li F., Li H.T., Li H.L., Li J., Li J.J., Li J.Q., Li K.J., Li M.Z., Li N., Li Q.J., Li R.H., Li S.C., Li S.F., Li S.J., Li T., Li W.D., Li W.G., Li X.M., Li X.N., Li X.L., Li X.Q., Li Y., Li Y.F., Li Z.B., Li Z.Y., Liang H., Liang J.J., Liebau D., Limphirat A., Limpijumnong S., Lin C.J., Lin G.L., Lin S.X., Lin T., Lin Y.H., Ling J.J., Link J.M., Lippi I., Littenberg L., Littlejohn B.R., Liu F., Liu H., Liu H.B., Liu H.D., Liu H.J., Liu H.T., Liu J.C., Liu J.L., Liu M., Liu Q., Liu R.X., Liu S.Y., Liu S.B., Liu S.L., Liu X.W., Liu Y., Lokhov A., Lombardi P., Loo K., Lorenz S., Lu C., Lu H.Q., Lu J.B., Lu J.G., Lu S.X., Lu X.X., Lubsandorzhiev B., Lubsandorzhiev S., Ludhova L., Luk K.B., Luo F.J., Luo G., Luo P.W., Luo S., Luo W.M., Lyashuk V., Ma Q.M., Ma S., Ma X.B., Ma X.Y., Ma Y.Q., Malyshkin Y., Mantovani F., Mao Y.J., Mari S.M., Marini F., Marium S., Marshall C., Martellini C., Martin-Chassard G., Caicedo D.A.M., Martini A., Martino J., Mayilyan D., McDonald K.T., McKeown R.D., Muller A., Meng G., Mednieks I., Meng Y., Meregaglia A., Meroni E., Meyhofer D., Mezzetto M., Miller J., Miramonti L., Monforte S., Montini P., Montuschi M., Morozov N., Muralidharan P., Napolitano J., Nastasi M., Naumov D.V., Naumova E., Nemchenok I., Nikolaev A., Ning F.P., Ning Z., Nunokawa H., Oberauer L., Ochoa-Ricoux J.P., Olshevskiy A., Ortica F., Pan H.R., Paoloni A., Park J., Parkalian N., Parmeggiano S., Patton S., Payupol T., Pec V., Pedretti D., Pei Y.T., Pelliccia N., Peng A.G., Peng H.P., Peng J.C., Perrot F., Petitjean P.A., Rico L.F.P., Popov A., Poussot P., Pratumwan W., Previtali E., Pun C.S.J., Qi F.Z., Qi M., Qian S., Qian X., Qian X.H., Qiao H., Qin Z.H., Qiu S.K., Rajput M., Ranucci G., Raper N., Re A., Rebber H., Rebii A., Ren B., Ren J., Reveco C.M., Rezinko T., Ricci B., Robens M., Roche M., Rodphai N., Rohwer L., Romani A., Rosero R., Roskovec B., Roth C., Ruan X.C., Ruan X.D., Rujirawat S., Rybnikov A., Sadovsky A., Saggese P., Salamanna G., Sangka A., Sanguansak N., Sawangwit U., Sawatzki J., Sawy F., Schever M., Schuler J., Schwab C., Schweizer K., Selivanov D., Selyunin A., Serafini A., Settanta G., Settimo M., Shahzad M., Shi G., Shi J.Y., Shi Y.J., Shutov V., Sidorenkov A., Simkovic F., Sirignano C., Siripak J., Sisti M., Slupecki M., Smirnov M., Smirnov O., Sogo-Bezerra T., Songwadhana J., Soonthornthum B., Sotnikov A., Sramek O., Sreethawong W., Stahl A., Stanco L., Stankevich K., Stefanik D., Steiger H., Steiner H., Steinmann J., Stender M., Strati V., Studenikin A., Sun G.X., Sun L.T., Sun J.L., Sun S.F., Sun X.L., Sun Y.J., Sun Y.Z., Suwonjandee N., Szelezniak M., Tang J., Tang Q., Tang X., Tietzsch A., Tkachev I., Tmej T., Treskov K., Troni G., Trzaska W., Tse W.-H., Tull C.E., Tuve C., van Waasen S., Boom J.V.D., Vassilopoulos N., Vedin V., Verde G., Vialkov M., Viaud B., Viren B., Volpe C., Vorobel V., Votano L., Walker P., Wang C., Wang C.H., Wang E., Wang G.L., Wang J., Wang K.Y., Wang L., Wang M.F., Wang M., Wang N.Y., Wang R.G., Wang S.G., Wang W., Wang W.S., Wang X., Wang X.Y., Wang Y., Wang Y.F., Wang Y.G., Wang Y.M., Wang Y.Q., Wang Z., Wang Z.M., Wang Z.Y., Watcharangkool A., Wei H.Y., Wei L.H., Wei W., Wei Y.D., Wen L.J., Whisnant K., White C.G., Wiebusch C., Wong S.C.F., Wong H.L.H., Wonsak B., Worcester E., Wu C.H., Wu D.R., Wu F.L., Wu Q., Wu W.J., Wu Z., Wurm M., Wurtz J., Wysotzki C., Xi Y.F., Xia D.M., Xie Y.G., Xie Z.Q., Xing Z.Z., Xu D.L., Xu F.R., Xu H.K., Xu J.L., Xu J., Xu M.H., Xu T., Xu Y., Xue T., Yan B.J., Yan X.B., Yan Y.P., Yang A.B., Yang C.G., Yang H., Yang J., Yang L., Yang X.Y., Yang Y.F., Yang Y.Z., Yao H.F., Yasin Z., Ye J.X., Ye M., Yegin U., Yeh M., Yermia F., Yi P.H., You Z.Y., Young B.L., Yu B.X., Yu C.X., Yu C.Y., Yu H.Z., Yu M., Yu X.H., Yu Z.Y., Yuan C.Z., Yuan Y., Yuan Z.X., Yuan Z.Y., Yue B.B., Zafar N., Zambanini A., Zeng P., Zeng S., Zeng T.X., Zeng Y.D., Zhan L., Zhang C., Zhang F.Y., Zhang G.Q., Zhang H.H., Zhang H.Q., Zhang J., Zhang J.B., Zhang J.W., Zhang P., Zhang Q.M., Zhang T., Zhang X.M., Zhang X.T., Zhang Y., Zhang Y.H., Zhang Y.M., Zhang Y.P., Zhang Y.X., Zhang Y.Y., Zhang Z.J., Zhang Z.P., Zhang Z.Y., Zhao F.Y., Zhao J., Zhao R., Zhao S.J., Zhao T.C., Zheng D.Q., Zheng H., Zheng M.S., Zheng Y.H., Zhong W.R., Zhou J., Zhou L., Zhou N., Zhou S., Zhou X., Zhu J., Zhu K.J., Zhuang H.L., Zong L., Zou J.H., Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), JUNO, Daya Bay, Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Abusleme, A, Adam, T, Ahmad, S, Aiello, S, Akram, M, Ali, N, An, F, An, G, An, Q, Andronico, G, Anfimov, N, Antonelli, V, Antoshkina, T, Asavapibhop, B, de Andre, J, Babic, A, Balantekin, A, Baldini, W, Baldoncini, M, Band, H, Barresi, A, Baussan, E, Bellato, M, Bernieri, E, Biare, D, Birkenfeld, T, Bishai, M, Blin, S, Blum, D, Blyth, S, Bordereau, C, Brigatti, A, Brugnera, R, Budano, A, Burgbacher, P, Buscemi, M, Bussino, S, Busto, J, Butorov, I, Cabrera, A, Cai, H, Cai, X, Cai, Y, Cai, Z, Cammi, A, Campeny, A, Cao, C, Cao, G, Cao, J, Caruso, R, Cerna, C, Chang, J, Chang, Y, Chen, H, Chen, P, Chen, S, Chen, X, Chen, Y, Chen, Z, Cheng, J, Cheng, Y, Cheng, Z, Chepurnov, A, Cherwinka, J, Chiarello, F, Chiesa, D, Chimenti, P, Chu, M, Chukanov, A, Chuvashova, A, Clementi, C, Clerbaux, B, Di Lorenzo, S, Corti, D, Costa, S, Dal Corso, F, Cummings, J, Dalager, O, De La Taille, C, Deng, F, Deng, J, Deng, Z, Depnering, W, Diaz, M, Ding, X, Ding, Y, Dirgantara, B, Dmitrievsky, S, Diwan, M, Dohnal, T, Donchenko, G, Dong, J, Dornic, D, Doroshkevich, E, Dove, J, Dracos, M, Druillole, F, Du, S, Dusini, S, Dvorak, M, Dwyer, D, Enqvist, T, Enzmann, H, Fabbri, A, Fajt, L, Fan, D, Fan, L, Fang, C, Fang, J, Fatkina, A, Fedoseev, D, Fekete, V, Feng, L, Feng, Q, Fiorentini, G, Ford, R, Formozov, A, Fournier, A, Franke, S, Gallo, J, Gan, H, Gao, F, Garfagnini, A, Gottel, A, Genster, C, Giammarchi, M, Giaz, A, Giudice, N, Giuliani, F, Gonchar, M, Gong, G, Gong, H, Gorchakov, O, Gornushkin, Y, Grassi, M, Grewing, C, Gromov, M, Gromov, V, Gu, M, Gu, W, Gu, X, Gu, Y, Guan, M, Guardone, N, Gul, M, Guo, C, Guo, J, Guo, L, Guo, W, Guo, X, Guo, Y, Guo, Z, Haacke, M, Hackenburg, R, Hackspacher, P, Hagner, C, Han, R, Han, Y, Hans, S, He, M, He, W, Heeger, K, Heinz, T, Heng, Y, Herrera, R, Higuera, A, Hong, D, Hor, Y, Hou, S, Hsiung, Y, Hu, B, Hu, H, Hu, J, Hu, S, Hu, T, Hu, Z, Huang, C, Huang, G, Huang, H, Huang, Q, Huang, W, Huang, X, Huang, Y, Huber, P, Hui, J, Huo, L, Huo, W, Huss, C, Hussain, S, Insolia, A, Ioannisian, A, Ioannisyan, D, Isocrate, R, Jaffe, D, Jen, K, Ji, X, Jia, H, Jia, J, Jian, S, Jiang, D, Jiang, X, Jin, R, Jing, X, Johnson, R, Jollet, C, Jones, D, Joutsenvaara, J, Jungthawan, S, Kalousis, L, Kampmann, P, Kang, L, Karagounis, M, Kazarian, N, Kettell, S, Khan, A, Khan, W, Khosonthongkee, K, Kinz, P, Kohn, S, Korablev, D, Kouzakov, K, Kramer, M, Krasnoperov, A, Krokhaleva, S, Krumshteyn, Z, Kruth, A, Kutovskiy, N, Kuusiniemi, P, Lachacinski, B, Lachenmaier, T, Landini, C, Langford, T, Lee, J, Lefevre, F, Lei, L, Lei, R, Leitner, R, Leung, J, Li, D, Li, F, Li, H, Li, J, Li, K, Li, M, Li, N, Li, Q, Li, R, Li, S, Li, T, Li, W, Li, X, Li, Y, Li, Z, Liang, H, Liang, J, Liebau, D, Limphirat, A, Limpijumnong, S, Lin, C, Lin, G, Lin, S, Lin, T, Lin, Y, Ling, J, Link, J, Lippi, I, Littenberg, L, Littlejohn, B, Liu, F, Liu, H, Liu, J, Liu, M, Liu, Q, Liu, R, Liu, S, Liu, X, Liu, Y, Lokhov, A, Lombardi, P, Loo, K, Lorenz, S, Lu, C, Lu, H, Lu, J, Lu, S, Lu, X, Lubsandorzhiev, B, Lubsandorzhiev, S, Ludhova, L, Luk, K, Luo, F, Luo, G, Luo, P, Luo, S, Luo, W, Lyashuk, V, Ma, Q, Ma, S, Ma, X, Ma, Y, Malyshkin, Y, Mantovani, F, Mao, Y, Mari, S, Marini, F, Marium, S, Marshall, C, Martellini, C, Martin-Chassard, G, Caicedo, D, Martini, A, Martino, J, Mayilyan, D, Mcdonald, K, Mckeown, R, Muller, A, Meng, G, Mednieks, I, Meng, Y, Meregaglia, A, Meroni, E, Meyhofer, D, Mezzetto, M, Miller, J, Miramonti, L, Monforte, S, Montini, P, Montuschi, M, Morozov, N, Muralidharan, P, Napolitano, J, Nastasi, M, Naumov, D, Naumova, E, Nemchenok, I, Nikolaev, A, Ning, F, Ning, Z, Nunokawa, H, Oberauer, L, Ochoa-Ricoux, J, Olshevskiy, A, Ortica, F, Pan, H, Paoloni, A, Park, J, Parkalian, N, Parmeggiano, S, Patton, S, Payupol, T, Pec, V, Pedretti, D, Pei, Y, Pelliccia, N, Peng, A, Peng, H, Peng, J, Perrot, F, Petitjean, P, Rico, L, Popov, A, Poussot, P, Pratumwan, W, Previtali, E, Pun, C, Qi, F, Qi, M, Qian, S, Qian, X, Qiao, H, Qin, Z, Qiu, S, Rajput, M, Ranucci, G, Raper, N, Re, A, Rebber, H, Rebii, A, Ren, B, Ren, J, Reveco, C, Rezinko, T, Ricci, B, Robens, M, Roche, M, Rodphai, N, Rohwer, L, Romani, A, Rosero, R, Roskovec, B, Roth, C, Ruan, X, Rujirawat, S, Rybnikov, A, Sadovsky, A, Saggese, P, Salamanna, G, Sangka, A, Sanguansak, N, Sawangwit, U, Sawatzki, J, Sawy, F, Schever, M, Schuler, J, Schwab, C, Schweizer, K, Selivanov, D, Selyunin, A, Serafini, A, Settanta, G, Settimo, M, Shahzad, M, Shi, G, Shi, J, Shi, Y, Shutov, V, Sidorenkov, A, Simkovic, F, Sirignano, C, Siripak, J, Sisti, M, Slupecki, M, Smirnov, M, Smirnov, O, Sogo-Bezerra, T, Songwadhana, J, Soonthornthum, B, Sotnikov, A, Sramek, O, Sreethawong, W, Stahl, A, Stanco, L, Stankevich, K, Stefanik, D, Steiger, H, Steiner, H, Steinmann, J, Stender, M, Strati, V, Studenikin, A, Sun, G, Sun, L, Sun, J, Sun, S, Sun, X, Sun, Y, Suwonjandee, N, Szelezniak, M, Tang, J, Tang, Q, Tang, X, Tietzsch, A, Tkachev, I, Tmej, T, Treskov, K, Troni, G, Trzaska, W, Tse, W, Tull, C, Tuve, C, van Waasen, S, Boom, J, Vassilopoulos, N, Vedin, V, Verde, G, Vialkov, M, Viaud, B, Viren, B, Volpe, C, Vorobel, V, Votano, L, Walker, P, Wang, C, Wang, E, Wang, G, Wang, J, Wang, K, Wang, L, Wang, M, Wang, N, Wang, R, Wang, S, Wang, W, Wang, X, Wang, Y, Wang, Z, Watcharangkool, A, Wei, H, Wei, L, Wei, W, Wei, Y, Wen, L, Whisnant, K, White, C, Wiebusch, C, Wong, S, Wong, H, Wonsak, B, Worcester, E, Wu, C, Wu, D, Wu, F, Wu, Q, Wu, W, Wu, Z, Wurm, M, Wurtz, J, Wysotzki, C, Xi, Y, Xia, D, Xie, Y, Xie, Z, Xing, Z, Xu, D, Xu, F, Xu, H, Xu, J, Xu, M, Xu, T, Xu, Y, Xue, T, Yan, B, Yan, X, Yan, Y, Yang, A, Yang, C, Yang, H, Yang, J, Yang, L, Yang, X, Yang, Y, Yao, H, Yasin, Z, Ye, J, Ye, M, Yegin, U, Yeh, M, Yermia, F, Yi, P, You, Z, Young, B, Yu, B, Yu, C, Yu, H, Yu, M, Yu, X, Yu, Z, Yuan, C, Yuan, Y, Yuan, Z, Yue, B, Zafar, N, Zambanini, A, Zeng, P, Zeng, S, Zeng, T, Zeng, Y, Zhan, L, Zhang, C, Zhang, F, Zhang, G, Zhang, H, Zhang, J, Zhang, P, Zhang, Q, Zhang, T, Zhang, X, Zhang, Y, Zhang, Z, Zhao, F, Zhao, J, Zhao, R, Zhao, S, Zhao, T, Zheng, D, Zheng, H, Zheng, M, Zheng, Y, Zhong, W, Zhou, J, Zhou, L, Zhou, N, Zhou, S, Zhou, X, Zhu, J, Zhu, K, Zhuang, H, Zong, L, Zou, J, Abusleme, A., Adam, T., Ahmad, S., Aiello, S., Akram, M., Ali, N., An, F. P., An, G. P., An, Q., Andronico, G., Anfimov, N., Antonelli, V., Antoshkina, T., Asavapibhop, B., de Andre, J. P. A. M., Babic, A., Balantekin, A. B., Baldini, W., Baldoncini, M., Band, H. R., Barresi, A., Baussan, E., Bellato, M., Bernieri, E., Biare, D., Birkenfeld, T., Bishai, M., Blin, S., Blum, D., Blyth, S., Bordereau, C., Brigatti, A., Brugnera, R., Budano, A., Burgbacher, P., Buscemi, M., Bussino, S., Busto, J., Butorov, I., Cabrera, A., Cai, H., Cai, X., Cai, Y. K., Cai, Z. Y., Cammi, A., Campeny, A., Cao, C. Y., Cao, G. F., Cao, J., Caruso, R., Cerna, C., Chang, J. F., Chang, Y., Chen, H. S., Chen, P. A., Chen, P. P., Chen, S. M., Chen, S. J., Chen, X. R., Chen, Y. W., Chen, Y. X., Chen, Y., Chen, Z., Cheng, J., Cheng, Y. P., Cheng, Z. K., Chepurnov, A., Cherwinka, J. J., Chiarello, F., Chiesa, D., Chimenti, P., Chu, M. C., Chukanov, A., Chuvashova, A., Clementi, C., Clerbaux, B., Di Lorenzo, S. C., Corti, D., Costa, S., Dal Corso, F., Cummings, J. P., Dalager, O., De La Taille, C., Deng, F. S., Deng, J. W., Deng, Z., Deng, Z. Y., Depnering, W., Diaz, M., Ding, X. F., Ding, Y. Y., Dirgantara, B., Dmitrievsky, S., Diwan, M. V., Dohnal, T., Donchenko, G., Dong, J. M., Dornic, D., Doroshkevich, E., Dove, J., Dracos, M., Druillole, F., Du, S. X., Dusini, S., Dvorak, M., Dwyer, D. A., Enqvist, T., Enzmann, H., Fabbri, A., Fajt, L., Fan, D. H., Fan, L., Fang, C., Fang, J., Fatkina, A., Fedoseev, D., Fekete, V., Feng, L. C., Feng, Q. C., Fiorentini, G., Ford, R., Formozov, A., Fournier, A., Franke, S., Gallo, J. P., Gan, H. N., Gao, F., Garfagnini, A., Gottel, A., Genster, C., Giammarchi, M., Giaz, A., Giudice, N., Giuliani, F., Gonchar, M., Gong, G. H., Gong, H., Gorchakov, O., Gornushkin, Y., Grassi, M., Grewing, C., Gromov, M., Gromov, V., Gu, M. H., Gu, W. Q., Gu, X. F., Gu, Y., Guan, M. Y., Guardone, N., Gul, M., Guo, C., Guo, J. Y., Guo, L., Guo, W. L., Guo, X. H., Guo, Y. H., Guo, Z., Haacke, M., Hackenburg, R. W., Hackspacher, P., Hagner, C., Han, R., Han, Y., Hans, S., He, M., He, W., Heeger, K. M., Heinz, T., Heng, Y. K., Herrera, R., Higuera, A., Hong, D. J., Hor, Y. K., Hou, S. J., Hsiung, Y. B., Hu, B. Z., Hu, H., Hu, J. R., Hu, J., Hu, S. Y., Hu, T., Hu, Z. J., Huang, C. H., Huang, G. H., Huang, H. X., Huang, Q. H., Huang, W. H., Huang, X. T., Huang, Y. B., Huber, P., Hui, J. Q., Huo, L., Huo, W. J., Huss, C., Hussain, S., Insolia, A., Ioannisian, A., Ioannisyan, D., Isocrate, R., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Ji, X. Z., Jia, H. H., Jia, J. J., Jian, S. Y., Jiang, D., Jiang, X. S., Jin, R. Y., Jing, X. P., Johnson, R. A., Jollet, C., Jones, D., Joutsenvaara, J., Jungthawan, S., Kalousis, L., Kampmann, P., Kang, L., Karagounis, M., Kazarian, N., Kettell, S. H., Khan, A., Khan, W., Khosonthongkee, K., Kinz, P., Kohn, S., Korablev, D., Kouzakov, K., Kramer, M., Krasnoperov, A., Krokhaleva, S., Krumshteyn, Z., Kruth, A., Kutovskiy, N., Kuusiniemi, P., Lachacinski, B., Lachenmaier, T., Landini, C., Langford, T. J., Lee, J., Lee, J. H. C., Lefevre, F., Lei, L., Lei, R., Leitner, R., Leung, J., Li, D. M., Li, F., Li, H. T., Li, H. L., Li, J., Li, J. J., Li, J. Q., Li, K. J., Li, M. Z., Li, N., Li, Q. J., Li, R. H., Li, S. C., Li, S. F., Li, S. J., Li, T., Li, W. D., Li, W. G., Li, X. M., Li, X. N., Li, X. L., Li, X. Q., Li, Y., Li, Y. F., Li, Z. B., Li, Z. Y., Liang, H., Liang, J. J., Liebau, D., Limphirat, A., Limpijumnong, S., Lin, C. J., Lin, G. L., Lin, S. X., Lin, T., Lin, Y. H., Ling, J. J., Link, J. M., Lippi, I., Littenberg, L., Littlejohn, B. R., Liu, F., Liu, H., Liu, H. B., Liu, H. D., Liu, H. J., Liu, H. T., Liu, J. C., Liu, J. L., Liu, M., Liu, Q., Liu, R. X., Liu, S. Y., Liu, S. B., Liu, S. L., Liu, X. W., Liu, Y., Lokhov, A., Lombardi, P., Loo, K., Lorenz, S., Lu, C., Lu, H. Q., Lu, J. B., Lu, J. G., Lu, S. X., Lu, X. X., Lubsandorzhiev, B., Lubsandorzhiev, S., Ludhova, L., Luk, K. B., Luo, F. J., Luo, G., Luo, P. W., Luo, S., Luo, W. M., Lyashuk, V., Ma, Q. M., Ma, S., Ma, X. B., Ma, X. Y., Ma, Y. Q., Malyshkin, Y., Mantovani, F., Mao, Y. J., Mari, S. M., Marini, F., Marium, S., Marshall, C., Martellini, C., Martin-Chassard, G., Caicedo, D. A. M., Martini, A., Martino, J., Mayilyan, D., Mcdonald, K. T., Mckeown, R. D., Muller, A., Meng, G., Mednieks, I., Meng, Y., Meregaglia, A., Meroni, E., Meyhofer, D., Mezzetto, M., Miller, J., Miramonti, L., Monforte, S., Montini, P., Montuschi, M., Morozov, N., Muralidharan, P., Napolitano, J., Nastasi, M., Naumov, D. V., Naumova, E., Nemchenok, I., Nikolaev, A., Ning, F. P., Ning, Z., Nunokawa, H., Oberauer, L., Ochoa-Ricoux, J. P., Olshevskiy, A., Ortica, F., Pan, H. R., Paoloni, A., Park, J., Parkalian, N., Parmeggiano, S., Patton, S., Payupol, T., Pec, V., Pedretti, D., Pei, Y. T., Pelliccia, N., Peng, A. G., Peng, H. P., Peng, J. C., Perrot, F., Petitjean, P. A., Rico, L. F. P., Popov, A., Poussot, P., Pratumwan, W., Previtali, E., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, S., Qian, X., Qian, X. H., Qiao, H., Qin, Z. H., Qiu, S. K., Rajput, M., Ranucci, G., Raper, N., Re, A., Rebber, H., Rebii, A., Ren, B., Ren, J., Reveco, C. M., Rezinko, T., Ricci, B., Robens, M., Roche, M., Rodphai, N., Rohwer, L., Romani, A., Rosero, R., Roskovec, B., Roth, C., Ruan, X. C., Ruan, X. D., Rujirawat, S., Rybnikov, A., Sadovsky, A., Saggese, P., Salamanna, G., Sangka, A., Sanguansak, N., Sawangwit, U., Sawatzki, J., Sawy, F., Schever, M., Schuler, J., Schwab, C., Schweizer, K., Selivanov, D., Selyunin, A., Serafini, A., Settanta, G., Settimo, M., Shahzad, M., Shi, G., Shi, J. Y., Shi, Y. J., Shutov, V., Sidorenkov, A., Simkovic, F., Sirignano, C., Siripak, J., Sisti, M., Slupecki, M., Smirnov, M., Smirnov, O., Sogo-Bezerra, T., Songwadhana, J., Soonthornthum, B., Sotnikov, A., Sramek, O., Sreethawong, W., Stahl, A., Stanco, L., Stankevich, K., Stefanik, D., Steiger, H., Steiner, H., Steinmann, J., Stender, M., Strati, V., Studenikin, A., Sun, G. X., Sun, L. T., Sun, J. L., Sun, S. F., Sun, X. L., Sun, Y. J., Sun, Y. Z., Suwonjandee, N., Szelezniak, M., Tang, J., Tang, Q., Tang, X., Tietzsch, A., Tkachev, I., Tmej, T., Treskov, K., Troni, G., Trzaska, W., Tse, W. -H., Tull, C. E., Tuve, C., van Waasen, S., Boom, J. V. D., Vassilopoulos, N., Vedin, V., Verde, G., Vialkov, M., Viaud, B., Viren, B., Volpe, C., Vorobel, V., Votano, L., Walker, P., Wang, C., Wang, C. H., Wang, E., Wang, G. L., Wang, J., Wang, K. Y., Wang, L., Wang, M. F., Wang, M., Wang, N. Y., Wang, R. G., Wang, S. G., Wang, W., Wang, W. S., Wang, X., Wang, X. Y., Wang, Y., Wang, Y. F., Wang, Y. G., Wang, Y. M., Wang, Y. Q., Wang, Z., Wang, Z. M., Wang, Z. Y., Watcharangkool, A., Wei, H. Y., Wei, L. H., Wei, W., Wei, Y. D., Wen, L. J., Whisnant, K., White, C. G., Wiebusch, C., Wong, S. C. F., Wong, H. L. H., Wonsak, B., Worcester, E., Wu, C. H., Wu, D. R., Wu, F. L., Wu, Q., Wu, W. J., Wu, Z., Wurm, M., Wurtz, J., Wysotzki, C., Xi, Y. F., Xia, D. M., Xie, Y. G., Xie, Z. Q., Xing, Z. Z., Xu, D. L., Xu, F. R., Xu, H. K., Xu, J. L., Xu, J., Xu, M. H., Xu, T., Xu, Y., Xue, T., Yan, B. J., Yan, X. B., Yan, Y. P., Yang, A. B., Yang, C. G., Yang, H., Yang, J., Yang, L., Yang, X. Y., Yang, Y. F., Yang, Y. Z., Yao, H. F., Yasin, Z., Ye, J. X., Ye, M., Yegin, U., Yeh, M., Yermia, F., Yi, P. H., You, Z. Y., Young, B. L., Yu, B. X., Yu, C. X., Yu, C. Y., Yu, H. Z., Yu, M., Yu, X. H., Yu, Z. Y., Yuan, C. Z., Yuan, Y., Yuan, Z. X., Yuan, Z. Y., Yue, B. B., Zafar, N., Zambanini, A., Zeng, P., Zeng, S., Zeng, T. X., Zeng, Y. D., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, G. Q., Zhang, H. H., Zhang, H. Q., Zhang, J., Zhang, J. B., Zhang, J. W., Zhang, P., Zhang, Q. M., Zhang, T., Zhang, X. M., Zhang, X. T., Zhang, Y., Zhang, Y. H., Zhang, Y. M., Zhang, Y. P., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, F. Y., Zhao, J., Zhao, R., Zhao, S. J., Zhao, T. C., Zheng, D. Q., Zheng, H., Zheng, M. S., Zheng, Y. H., Zhong, W. R., Zhou, J., Zhou, L., Zhou, N., Zhou, S., Zhou, X., Zhu, J., Zhu, K. J., Zhuang, H. L., Zong, L., and Zou, J. H.
- Subjects
organic compounds: admixture ,Nuclear and High Energy Physics ,Physics - Instrumentation and Detectors ,Liquid scintillator ,scintillation counter: liquid ,Analytical chemistry ,FOS: Physical sciences ,model: optical ,Scintillator ,Wavelength shifter ,antineutrino: detector ,01 natural sciences ,NO ,High Energy Physics - Experiment ,wavelength shifter ,High Energy Physics - Experiment (hep-ex) ,PE2_2 ,Daya Bay ,Neutrino ,0103 physical sciences ,fluorine: admixture ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,ddc:530 ,neutrino oscillation ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,010306 general physics ,Instrumentation ,Jiangmen Underground Neutrino Observatory ,Physics ,JUNO ,010308 nuclear & particles physics ,Settore FIS/01 - Fisica Sperimentale ,Detector ,Light yield ,Instrumentation and Detectors (physics.ins-det) ,Yield (chemistry) ,Scintillation counter ,Composition (visual arts) ,photon: yield - Abstract
To maximize the light yield of the liquid scintillator (LS) for the Jiangmen Underground Neutrino Observatory (JUNO), a 20 t LS sample was produced in a pilot plant at Daya Bay. The optical properties of the new LS in various compositions were studied by replacing the gadolinium-loaded LS in one antineutrino detector. The concentrations of the fluor, PPO, and the wavelength shifter, bis-MSB, were increased in 12 steps from 0.5 g/L and, 13 pages, 8 figures
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- 2021
17. Prevalence and risk factors of peripheral artery disease in a population with chronic kidney disease in Australia: A systematic review and meta-analysis
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Pranav S. Garimella, Shirley Jansen, Kunihiro Matsushita, Hui J Chih, Christopher M. Reid, and Chau L. B. Ho
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Male ,medicine.medical_specialty ,Arterial disease ,medicine.medical_treatment ,Population ,030232 urology & nephrology ,Disease ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Risk Assessment ,03 medical and health sciences ,Peripheral Arterial Disease ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Prevalence ,Humans ,Renal Insufficiency, Chronic ,education ,Dialysis ,Aged ,Aged, 80 and over ,education.field_of_study ,business.industry ,Absolute risk reduction ,Australia ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,body regions ,Blood pressure ,Nephrology ,Meta-analysis ,Female ,business ,Kidney disease - Abstract
There is a lack of clarity and guidance for screening peripheral artery disease (PAD) in persons with chronic kidney disease (CKD) and end stage kidney disease (ESKD) despite this group being at excess risk of cardiovascular disease (CVD). In this current study, we performed a systematic review and meta-analysis to examine the prevalence and risk factors for PAD in persons with CKD in Australian cohorts. We used the inverse variance heterogeneity meta-analysis with double arcsine transformation to summarize the prevalence of PAD (with 95% CIs). Nine studies and 18 reports from the Australia and New Zealand dialysis and transplant registry with 36 cohorts were included in the review. We found a substantially higher PAD prevalence in cohorts based on an ankle-brachial index (ABI) or toe systolic pressure (TBI) than cohorts based on self-reported history. Higher PAD prevalence was observed in ESKD persons than CKD persons without dialysis (PAD diagnosis based on ABI or TBI: 31% in ESKD persons and 23% in CKD persons, PAD diagnosis based on self-reported history: 17% in ESKD persons and 10% in CKD persons). Older age, Caucasian race, cerebrovascular disease and haemodialysis were associated with the presence of PAD in ESKD persons. Our findings indicated a considerable proportion of PAD in CKD and ESKD persons particularly in those with ESKD. To develop and provide an adequate plan to clinically manage CKD patients with PAD, evidence of cost-effectiveness and clinical benefit of early detection of PAD in persons with CKD in Australia is recommended for future studies.
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- 2021
18. Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation
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Lyle Babcock, Hui J. Wang, Joseph Recio, Amy D. Hanna, Susan L. Hamilton, and Chang Seok Lee
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Male ,0301 basic medicine ,Protein aggregation ,medicine.disease_cause ,Calsequestrin ,Biochemistry ,Article ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Muscular Diseases ,Genetics ,medicine ,Protein biosynthesis ,Animals ,Muscle, Skeletal ,Myopathy ,Molecular Biology ,Mutation ,Chemistry ,Endoplasmic reticulum ,Calcium-Binding Proteins ,Endoplasmic Reticulum Stress ,Cell biology ,Lysosomal Storage Diseases ,Sarcoplasmic Reticulum ,030104 developmental biology ,Proteasome ,Unfolded protein response ,Calcium ,medicine.symptom ,030217 neurology & neurosurgery ,Biotechnology - Abstract
Mice with a mutation (D244G, DG) in calsequestrin 1 (CASQ1), analogous to a human mutation in CASQ1 associated with a delayed onset human myopathy (vacuolar aggregate myopathy), display a progressive myopathy characterized by decreased activity, decreased ability of fast twitch muscles to generate force and low body weight after one year of age. The DG mutation causes CASQ1 to partially dissociate from the junctional sarcoplasmic reticulum (SR) and accumulate in the endoplasmic reticulum (ER). Decreased junctional CASQ1 reduces SR Ca(2+) release. Muscles from older DG mice display ER stress, ER expansion, increased mTOR signaling, inadequate clearance of aggregated proteins by the proteasomes, and elevation of protein aggregates and lysosomes. This study suggests that the myopathy associated with the D244G mutation in CASQ1 is driven by CASQ1 mislocalization, reduced SR Ca(2+) release, CASQ1 misfolding/aggregation and ER stress. The subsequent maladaptive increase in protein synthesis and decreased protein aggregate clearance are likely to contribute to disease progression.
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- 2021
19. Primary Cutaneous Extranodal NK/T Cell Lymphoma (Nasal Type): A Case Report and Review of Literatures
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Lijie W, Feng J, Qian Z, Hui J, Jie B, Yang L, Kaiping B, Ruijuan C, yue LQ, Jingjing W, Ziyan Z, Hanghang Z, Xin M, Xudong S, Liru D, Dan L, and Jie Y
- Abstract
A case of extranodal NK/T cell lymphoma (nasal type) with skin lesion as the first manifestation is reported. A 82 year old female presented with fever for 10 days, and mass with ulceration on right shoulder for 4 days. Clinically, a walnut-sized red mass with local ulceration and scab can be seen on the right shoulder. Part of the lesion had rupture scab. A circular-like infiltrated dark red plaque with a diameter of about 4cm can be seen on the right chest, with yellow and white dry secretion in the center. Multiple patches of dark red spots from coins to walnuts can be seen on the trunk and limbs. Based on skin lesions, histological, immunohistochemical staining and EBER in situ hybridization, a diagnose of primary cutaneous extranodal NK/T cell lymphoma, nasal type was made.
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- 2021
20. Effects of Peer Influences and Life-History Strategy on Chinese Junior High School Students’ Prosocial and Antisocial Behaviors
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Hui J. Lu, Nan Zhu, and Lei Chang
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migrant students ,peer influence ,media_common.quotation_subject ,Prestige ,05 social sciences ,prosociality ,050301 education ,lcsh:Education (General) ,050105 experimental psychology ,Education ,Life history theory ,Developmental psychology ,Friendship ,Prosocial behavior ,life history strategy ,friendship ,Peer influence ,adolescence ,0501 psychology and cognitive sciences ,lcsh:L7-991 ,Psychology ,0503 education ,media_common - Abstract
Peer influence and life-history strategy have been shown in previous research as facilitators of adolescents’ social conduct. The current research uses the data from a two-wave, nationally representative survey of Chinese junior high school students to examine how different aspects of peer influence and life-history strategy in Grade 7 might contribute to prosocial and antisocial behaviors in Grade 8. We also considered differences between local and migrant students. The results showed that friend prestige predicted more prosocial behaviors and less antisocial behaviors, whereas friend deviancy predicted less prosocial behaviors and more antisocial behaviors. Moreover, the facilitating effect of friend deviancy on antisocial behaviors was amplified in migrant students more than for local students. Slow life-history strategy predicted more prosocial behaviors and, especially for migrant students, less antisocial behaviors. These findings indicate adolescents’ migrant backgrounds deserve extra attention when investigating peer influence and life-history strategy as distinct contributors to adolescents’ social conduct.
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- 2020
21. Contralateral Hemispheric Cerebral Blood Flow Measured With Arterial Spin Labeling Can Predict Outcome in Acute Stroke
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Thamm, Thoralf, Guo, Jia, Rosenberg, Jarrett, Liang, Tie, Marks, Michael P, Christensen, Soren, Do, Huy M, Kemp, Stephanie M, Adair, Emma, Eyngorn, Irina, Mlynash, Michael, Jovin, Tudor G, Keogh, Bart P, Chen, Hui J, Lansberg, Maarten G, Albers, Gregory W, and Zaharchuk, Greg
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iCAS Study Investigators ,Male ,Clinical Sciences ,perfusion imaging ,Neuroimaging ,Cardiorespiratory Medicine and Haematology ,Brain Ischemia ,Clinical Research ,Humans ,magnetic resonance imaging ,Prospective Studies ,Aged ,screening and diagnosis ,Neurology & Neurosurgery ,Neurosciences ,Brain ,Middle Aged ,stroke ,Brain Disorders ,Detection ,Treatment Outcome ,Cerebrovascular Circulation ,Biomedical Imaging ,Female ,prognosis ,4.2 Evaluation of markers and technologies - Abstract
Background and Purpose- Imaging is frequently used to select acute stroke patients for intra-arterial therapy. Quantitative cerebral blood flow can be measured noninvasively with arterial spin labeling magnetic resonance imaging. Cerebral blood flow levels in the contralateral (unaffected) hemisphere may affect capacity for collateral flow and patient outcome. The goal of this study was to determine whether higher contralateral cerebral blood flow (cCBF) in acute stroke identifies patients with better 90-day functional outcome. Methods- Patients were part of the prospective, multicenter iCAS study (Imaging Collaterals in Acute Stroke) between 2013 and 2017. Consecutive patients were enrolled after being diagnosed with anterior circulation acute ischemic stroke. Inclusion criteria were ischemic anterior circulation stroke, baseline National Institutes of Health Stroke Scale score ≥1, prestroke modified Rankin Scale score ≤2, onset-to-imaging time
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- 2019
22. Quality control and conduct of genome-wide association meta-analyses
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Winkler, T, Day, F, Croteau Chonka, D, Wood, A, Locke, A, Mägi, R, Ferreira, T, Fall, T, Graff, M, Justice, A, Luan, J, Gustafsson, S, Randall, J, Vedantam, S, Workalemahu, T, Kilpeläinen, T, Scherag, A, Esko, T, Kutalik, Z, Heid, I, Loos, R, Abecasis GR, Absher D, Alavere H, Albrecht E, Allen HL, Almgren P, Amin N, Amouyel P, Anderson D, Arnold AM, Arveiler D, Aspelund T, Asselbergs FW, Assimes TL, Atalay M, Attwood AP, Atwood LD, Bakker SJ, Balkau B, Balmforth AJ, Barlassina C, Barroso I, Basart H, Bauer S, Beckmann JS, Beilby JP, Bennett AJ, Ben Shlomo Y, Bergman RN, Bergmann S, Berndt SI, Biffar R, Di Blasio AM, Boehm BO, Boehnke M, Boeing H, Boerwinkle E, Bolton JL, Bonnefond A, Bonnycastle LL, Boomsma DI, Borecki IB, Bornstein SR, Bouatia Naji N, Boucher G, Bragg Gresham JL, BRAMBILLA, PAOLO, Bruinenberg M, Buchanan TA, Buechler C, Cadby G, Campbell H, Caulfield MJ, Cavalcanti Proença C, CESANA, GIANCARLO, Chanock SJ, Chasman DI, Chen YD, Chines PS, Clegg DJ, Coin L, Collins FS, 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Zillikens MC, Zitting P, Zondervan KT, Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), Winkler, T, Day, F, Croteau Chonka, D, Wood, A, Locke, A, Mägi, R, Ferreira, T, Fall, T, Graff, M, Justice, A, Luan, J, Gustafsson, S, Randall, J, Vedantam, S, Workalemahu, T, Kilpeläinen, T, Scherag, A, Esko, T, Kutalik, Z, Heid, I, Loos, R, Abecasis, G, Absher, D, Alavere, H, Albrecht, E, Allen, H, Almgren, P, Amin, N, Amouyel, P, Anderson, D, Arnold, A, Arveiler, D, Aspelund, T, Asselbergs, F, Assimes, T, Atalay, M, Attwood, A, Atwood, L, Bakker, S, Balkau, B, Balmforth, A, Barlassina, C, Barroso, I, Basart, H, Bauer, S, Beckmann, J, Beilby, J, Bennett, A, Ben Shlomo, Y, Bergman, R, Bergmann, S, Berndt, S, Biffar, R, Di Blasio, A, Boehm, B, Boehnke, M, Boeing, H, Boerwinkle, E, Bolton, J, Bonnefond, A, Bonnycastle, L, Boomsma, D, Borecki, I, Bornstein, S, Bouatia Naji, N, Boucher, G, Bragg Gresham, J, Brambilla, P, Bruinenberg, M, 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Paternoster, L., Pawitan, Y., Pechlivanis, S., Peden, JF., Pedersen, NL., Pedersen, O., Pellikka, N., Peltonen, L., Penninx, B., Perola, M., Perry, JR., Person, T., Peters, A., Peters, MJ., Pichler, I., Pietiläinen, KH., Platou, CG., Polasek, O., Pouta, A., Power, C., Pramstaller, PP., Preuss, M., Price, JF., Prokopenko, I., Province, MA., Psaty, BM., Purcell, S., Pütter, C., Qi, L., Quertermous, T., Radhakrishnan, A., Raitakari, O., Randall, JC., Rauramaa, R., Rayner, NW., Rehnberg, E., Rendon, A., Ridderstråle, M., Ridker, PM., Ripatti, S., Rissanen, A., Rivadeneira, F., Rivolta, C., Robertson, NR., Rose, LM., Rudan, I., Saaristo, TE., Sager, H., Salomaa, V., Samani, NJ., Sambrook, JG., Sanders, AR., Sandholt, C., Sanna, S., Saramies, J., Schadt, EE., Scherag, A., Schipf, S., Schlessinger, D., Schreiber, S., Schunkert, H., Schwarz, PE., Scott, LJ., Shi, J., Shin, SY., Shuldiner, AR., Shungin, D., Signorini, S., Silander, K., Sinisalo, J., Skrobek, B., Smit, JH., Smith, AV., Smith, GD., Snieder, H., Soranzo, N., Sørensen, TI., Sovio, U., Spector, TD., Speliotes, EK., Stančáková, A., Stark, K., Stefansson, K., Steinthorsdottir, V., Stephens, JC., Stirrups, K., Stolk, RP., Strachan, DP., Strawbridge, RJ., Stringham, HM., Stumvoll, M., Surakka, I., Swift, AJ., Syvanen, AC., Tammesoo, ML., Teder-Laving, M., Teslovich, TM., Teumer, A., Theodoraki, EV., Thomson, B., Thorand, B., Thorleifsson, G., Thorsteinsdottir, U., Timpson, NJ., Tönjes, A., Tregouet, DA., Tremoli, E., Trip, MD., Tuomi, T., Tuomilehto, J., Tyrer, J., Uda, M., Uitterlinden, AG., Usala, G., Uusitupa, M., Valle, TT., Vandenput, L., Vatin, V., Vedantam, S., de Vegt, F., Vermeulen, SH., Viikari, J., Virtamo, J., Visscher, PM., Vitart, V., Van Vliet-Ostaptchouk JV., Voight, BF., Vollenweider, P., Volpato, CB., Völzke, H., Waeber, G., Waite, LL., Wallaschofski, H., Walters, GB., Wang, Z., Wareham, NJ., Watanabe, RM., Watkins, H., Weedon, MN., Welch, R., Weyant, RJ., Wheeler, E., White, CC., Wichmann, HE., Widen, E., Wild, SH., Willemsen, G., Willer, CJ., Wilsgaard, T., Wilson, JF., van Wingerden, S., Winkelmann, BR., Winkler, TW., Witte, DR., Witteman, JC., Wolffenbuttel, BH., Wong, A., Wood, AR., Workalemahu, T., Wright, AF., Yang, J., Yarnell, JW., Zgaga, L., Zhao, JH., Zillikens, MC., Zitting, P., and Zondervan, KT.
- Subjects
Quality Control ,Netherlands Twin Register (NTR) ,BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA ,media_common.quotation_subject ,quality control, GWAMAS ,Control (management) ,Medizin ,Genome-wide association study ,Biology ,Bioinformatics ,General Biochemistry, Genetics and Molecular Biology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Software ,SDG 17 - Partnerships for the Goals ,Meta-Analysis as Topic ,Comparable size ,Quality (business) ,030304 developmental biology ,media_common ,Protocol (science) ,0303 health sciences ,business.industry ,Software package ,Data science ,Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] ,Genome-Wide Association Study/methods ,Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5] ,quality control ,genome-wide association meta-analyses ,business ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
Item does not contain fulltext Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC at the study file level, the meta-level across studies and the meta-analysis output level. Real-world examples highlight issues experienced and solutions developed by the GIANT Consortium that has conducted meta-analyses including data from 125 studies comprising more than 330,000 individuals. We provide a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data. We also include details for the use of a powerful and flexible software package called EasyQC. Precise timings will be greatly influenced by consortium size. For consortia of comparable size to the GIANT Consortium, this protocol takes a minimum of about 10 months to complete.
- Published
- 2014
23. Juvenile female rats, but not male rats, show renewal, reinstatement, and spontaneous recovery following extinction of conditioned fear
- Author
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Jee Hyun Kim, Chun Hui J. Park, and Despina E. Ganella
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Male ,0301 basic medicine ,Cognitive Neuroscience ,Conditioning, Classical ,Spontaneous recovery ,Physiology ,Context (language use) ,Extinction, Psychological ,Rats, Sprague-Dawley ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Male rats ,medicine ,Animals ,Juvenile ,Freezing Reaction, Cataleptic ,Analysis of Variance ,Sex Characteristics ,Research ,Fear ,Recovery of Function ,Extinction (psychology) ,Rats ,030104 developmental biology ,Neuropsychology and Physiological Psychology ,Animals, Newborn ,Anxiety ,Female ,Analysis of variance ,medicine.symptom ,030217 neurology & neurosurgery ,Sex characteristics - Abstract
Anxiety disorders emerge early, and girls are significantly more likely to develop anxiety compared to boys. However, sex differences in fear during development are poorly understood. Therefore, we investigated juvenile male and female rats in the relapse behaviors following extinction of conditioned fear. In all experiments, 18-d-old rats first received three white-noise–footshock pairings on day 1. On day 2, extinction involved 60 white-noise alone trials. In experiment 1, we examined renewal by testing the rats in either the same or different context as extinction on day 3. Male rats did not show renewal, however, female rats showed renewal. Experiment 2 investigated reinstatement by giving rats either a mild reminder footshock or context exposure on day 3. When tested the next day, male rats did not show reinstatement, whereas female rats showed reinstatement. Experiment 3 investigated spontaneous recovery by testing the rats either 1 or 5 d following extinction. Male rats did not show any spontaneous recovery whereas female rats did. Taken together, fear regulation appear to be different in males versus females from early in development, which may explain why girls are more prone to suffer from anxiety disorders compared to boys.
- Published
- 2017
24. Diffusion tensor imaging tensor shape analysis for assessment of regional white matter differences
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Patricia I. Dickson, Hui J Lee, Dana M Middleton, N. Matthew Ellinwood, Steven Chen, Leonard E. White, James M. Provenzale, and Jonathan Y Li
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Physics ,Internal capsule ,medicine.diagnostic_test ,Brain ,Magnetic resonance imaging ,General Medicine ,Brain tissue ,White Matter ,030218 nuclear medicine & medical imaging ,White matter ,03 medical and health sciences ,Diffusion Tensor Imaging ,Dogs ,0302 clinical medicine ,medicine.anatomical_structure ,Nuclear magnetic resonance ,Region of interest ,Centrum semiovale ,medicine ,Animals ,Radiology, Nuclear Medicine and imaging ,Neurology (clinical) ,030217 neurology & neurosurgery ,Shape analysis (digital geometry) ,Diffusion MRI - Abstract
Purpose The purpose of this study was to investigate a novel tensor shape plot analysis technique of diffusion tensor imaging data as a means to assess microstructural differences in brain tissue. We hypothesized that this technique could distinguish white matter regions with different microstructural compositions. Methods Three normal canines were euthanized at seven weeks old. Their brains were imaged using identical diffusion tensor imaging protocols on a 7T small-animal magnetic resonance imaging system. We examined two white matter regions, the internal capsule and the centrum semiovale, each subdivided into an anterior and posterior region. We placed 100 regions of interest in each of the four brain regions. Eigenvalues for each region of interest triangulated onto tensor shape plots as the weighted average of three shape metrics at the plot's vertices: CS, CL, and CP. Results The distribution of data on the plots for the internal capsule differed markedly from the centrum semiovale data, thus confirming our hypothesis. Furthermore, data for the internal capsule were distributed in a relatively tight cluster, possibly reflecting the compact and parallel nature of its fibers, while data for the centrum semiovale were more widely distributed, consistent with the less compact and often crossing pattern of its fibers. This indicates that the tensor shape plot technique can depict data in similar regions as being alike. Conclusion Tensor shape plots successfully depicted differences in tissue microstructure and reflected the microstructure of individual brain regions. This proof of principle study suggests that if our findings are reproduced in larger samples, including abnormal white matter states, the technique may be useful in assessment of white matter diseases.
- Published
- 2017
25. Protective effects of breastfeeding against acute respiratory tract infections and diarrhoea: Findings of a cohort study
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Colin W. Binns, Raheema Abdul Raheem, and Hui J Chih
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Pediatrics ,medicine.medical_specialty ,Respiratory tract infections ,business.industry ,Breastfeeding ,Odds ratio ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Pediatrics, Perinatology and Child Health ,Infant morbidity ,Cohort ,Medicine ,Gestation ,030212 general & internal medicine ,Human research ,business ,Cohort study - Abstract
Aim The objective of this paper is to identify associations between breastfeeding and acute respiratory tract infections (ARTIs) and diarrhoea. Methods A cohort of 458 mothers was recruited at the antenatal clinics at Indira Gandhi Memorial and Abdul Rahman Dhon Kaleyfaanu Hospitals. Mothers were interviewed ‘face-to-face’ at 36 weeks of gestation and at 1, 3 and 6 months after delivery. The questionnaires included demographic information about parents, infant feeding methods and breastfeeding duration. The number of episodes of ARTIs and diarrhoea was also recorded. Ethics approval was obtained from the National Research Committee of the Maldives and Curtin University Human Research Ethics Committee. Descriptive, univariate, logistic and survival analyses were used to assess the effects of breastfeeding on infant ARTIs and diarrhoea. Results The partial, predominant and exclusive breastfeeding rates at 1 month were 98.9, 67.6 and 26.9%, respectively. The risk of acquiring ARTIs is significantly reduced when the infants were predominantly breastfed for 3 months (adjusted odds ratio (OR): 0.56, 95% of adjusted OR: 0.34–0.94) and 6 months (adjusted OR: 0.45, 95% of adjusted OR: 0.24–0.84). The risk of getting diarrhoea is significantly reduced even when the babies were partially breastfed for 6 months (adjusted OR): 0.31, 95% of adjusted OR: 0.11–0.90). Kaplan Meier curves demonstrated that the risk lowers with longer duration of breastfeeding. Conclusion Breastfeeding need to be promoted because the risk of infant morbidity is negatively associated with the duration of breastfeeding.
- Published
- 2017
26. Oligomeric form of C-terminal-binding protein coactivates NeuroD1-mediated transcription
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Andrew B. Leiter, Subir K. Ray, and Hui J. Li
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0301 basic medicine ,Mutant ,Biophysics ,KDM1A ,Cell Biology ,Biology ,Biochemistry ,Coactivation ,Molecular biology ,Cell biology ,03 medical and health sciences ,030104 developmental biology ,Structural Biology ,Transcription (biology) ,NEUROD1 ,Genetics ,Molecular Biology ,Transcription factor ,Corepressor ,Gene - Abstract
The mechanism underlying transcriptional coactivation by the corepressor C-terminal-binding protein (CtBP) is not established. We previously found that CtBP co-occupies several actively transcribed endocrine genes with the transcription factor NeuroD1 to paradoxically increase transcription by recruiting KDM1A and CoREST. While the importance of the oligomeric form of CtBP for corepression is well established, the role of oligomerization in transcriptional coactivation has received little attention. Here, we examined the importance of the oligomeric state of CtBP for coactivation of NeuroD1-dependent transcription by expressing a CtBP dimerization mutant in cells depleted of endogenous CtBP. Dimerization mutants failed to increase transcription or to associate with KDM1A and CoREST, suggesting that oligomeric, but not monomeric CtBP is required to recruit other proteins needed to activate transcription.
- Published
- 2016
27. Variability in donor organ offer acceptance and lung transplantation survival
- Author
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Matthew G. Hartwig, Michael S. Mulvihill, Muath Bishawi, Hui J. Lee, Morgan L. Cox, Jacob A. Klapper, Jeremy M. Weber, Babatunde A. Yerokun, Ashley Y. Choi, and Maragatha Kuchibhatla
- Subjects
Pulmonary and Respiratory Medicine ,Adult ,Male ,Tissue and Organ Procurement ,Waiting Lists ,medicine.medical_treatment ,030230 surgery ,Logistic regression ,Article ,Donor Selection ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,medicine ,Lung transplantation ,Humans ,Cumulative incidence ,Registries ,Risk factor ,Retrospective Studies ,Transplantation ,business.industry ,Hazard ratio ,Retrospective cohort study ,Fixed effects model ,Middle Aged ,Confidence interval ,Tissue Donors ,Transplant Recipients ,United States ,Survival Rate ,030228 respiratory system ,Surgery ,Female ,Cardiology and Cardiovascular Medicine ,business ,Demography ,Follow-Up Studies ,Lung Transplantation - Abstract
BACKGROUND Lung transplantation offers a survival benefit for patients with end-stage lung disease. When suitable donors are identified, centers must accept or decline the offer for a matched candidate on their waitlist. The degree to which variability in per-center offer acceptance practices impacts candidate survival is not established. The purpose of this study was to determine the degree of variability in per-center rates of lung transplantation offer acceptance and to ascertain the associated contribution to observed differences in per-center waitlist mortality. METHODS We performed a retrospective cohort study of candidates waitlisted for lung transplantation in the US using registry data. Logistic regression was fit to assess the relationship of offer acceptance with donor, candidate, and geographic factors. Listing center was evaluated as a fixed effect to determine the adjusted per-center acceptance rate. Competing risks analysis employing the Fine-Gray model was undertaken to establish the relationship between adjusted per-center acceptance and waitlist mortality. RESULTS Of 15,847 unique organ offers, 4,735 (29.9%) were accepted for first-ranked candidates. After adjustment for important covariates, transplant centers varied markedly in acceptance rate (9%–67%). Higher cumulative incidence of 1-year waitlist mortality was associated with lower acceptance rate. For every 10% increase in adjusted center acceptance rate, the risk of waitlist mortality decreased by 36.3% (sub-distribution hazard ratio 0.637; 95% confidence interval 0.592–0.685). CONCLUSIONS Variability in center-level behavior represents a modifiable risk factor for waitlist mortality in lung transplantation. Further intervention is needed to standardize center-level offer acceptance practices and minimize waitlist mortality.
- Published
- 2019
28. Comparative cost-effectiveness of 11 oral antipsychotics for relapse prevention in schizophrenia within Singapore using effectiveness estimates from a network meta-analysis
- Author
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Ying J. Zhao, Kang Sim, Ai L. Khoo, Boon Peng Lim, Liang Lin, Lay B. Soh, Hui J. Zhou, and Monica Teng
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Adult ,Male ,Olanzapine ,medicine.medical_specialty ,Time Factors ,Cost effectiveness ,Cost-Benefit Analysis ,Administration, Oral ,Relapse prevention ,Drug Costs ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,medicine ,Humans ,Pharmacology (medical) ,Ziprasidone ,Paliperidone ,030212 general & internal medicine ,Amisulpride ,Psychiatry ,health care economics and organizations ,Singapore ,business.industry ,030503 health policy & services ,Middle Aged ,Markov Chains ,Psychiatry and Mental health ,Models, Economic ,Treatment Outcome ,Emergency medicine ,Quality of Life ,Schizophrenia ,Quetiapine ,Female ,Schizophrenic Psychology ,Aripiprazole ,Quality-Adjusted Life Years ,0305 other medical science ,business ,Antipsychotic Agents ,medicine.drug - Abstract
This study modelled the cost-effectiveness of 11 oral antipsychotics for relapse prevention among patients with remitted schizophrenia in Singapore. A network meta-analysis determined the relative efficacy and tolerability of 11 oral antipsychotics (amisulpride, aripiprazole, chlorpromazine, haloperidol, olanzapine, paliperidone, quetiapine, risperidone, sulpiride, trifluoperazine and ziprasidone). The clinical estimates were applied in a Markov model to estimate lifetime costs and quality-adjusted life-years gained. Quality-of-life data were obtained from published literature. Resource utilization and cost data were retrieved from local hospital databases. The annual direct cost of healthcare services for a patient experiencing a relapse episode was three-fold that of a patient not in relapse of schizophrenia. The most favourable pharmacological treatment for relapse prevention was olanzapine with an annual probability of relapse of 0.24 (0.13-0.38) with placebo as a reference of 0.75 (0.73-0.78). Olanzapine emerged as the dominant treatment with the highest quality-adjusted life-years gained and lowest lifetime costs. Ziprasidone, aripiprazole and paliperidone incurred higher lifetime costs compared with no treatment. Probability and cost of relapse were key drivers of cost-effectiveness in sensitivity analyses. The data can help prescribers in choosing appropriate treatment and payers in allocating resources for the clinical management of this serious psychiatric disorder.
- Published
- 2016
29. Dissociated roles of dorsal and ventral hippocampus in recall and extinction of conditioned fear in male and female juvenile rats
- Author
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Chun Hui J. Park, Jee Hyun Kim, Christina J. Perry, and Despina E. Ganella
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Male ,0301 basic medicine ,medicine.medical_specialty ,Conditioning, Classical ,Hippocampus ,Context (language use) ,Biology ,Amygdala ,Extinction, Psychological ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Developmental Neuroscience ,Internal medicine ,medicine ,Animals ,Juvenile ,natural sciences ,GABA-A Receptor Agonists ,Prefrontal cortex ,Muscimol ,Fear ,social sciences ,Extinction (psychology) ,musculoskeletal system ,humanities ,Rats ,Infusions, Intraventricular ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,Neurology ,Prenatal stress ,chemistry ,Mental Recall ,Female ,geographic locations ,030217 neurology & neurosurgery - Abstract
Reduction of conditioned fear expression by extinction underlies cue exposure therapies that treat anxiety disorders. Extinction is context-specific. Renewal, for example, is the relapse of extinguished fear when subjects are tested in a different context to extinction. This context-specificity is developmentally regulated and sex-dependent, with renewal being observed in postnatal day (P) 18 female, but not in male, rats. Given the hippocampus (HPC) is critical for context-specific extinction in adult rodents, we investigated dorsal or ventral hippocampus (dHPC or vHPC) involvement in context-specific extinction in P18 male and female rats. We microinfused muscimol (GABAA agonist) to inactivate either structure before extinction, then tested rats for renewal the next day. Regardless of sex, dHPC inactivation accelerated extinction acquisition, while vHPC inactivation reduced fear expression during extinction and impaired extinction recall. Consistent with previous findings, renewal was observed in females but not in males. Surprisingly, inactivation of dHPC or vHPC had no effects on renewal in either sex, indicating that the hippocampus does not play a critical role in context-dependent extinction learning in juvenile rats. These findings are the first to demonstrate dissociated roles of dHPC and vHPC in conditioned fear expression and extinction in juvenile rats. In addition, context-specific extinction shown by juvenile females, but not males, likely is not due to potential sex differences in hippocampus involvement in extinction of conditioned fear in developing rats.
- Published
- 2020
30. Factors Associated With Maternal Depression in the Maldives: A Prospective Cohort Study
- Author
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Colin W. Binns, R Abdul Raheem, and Hui J Chih
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Adult ,medicine.medical_specialty ,Adolescent ,Mothers ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Indian Ocean Islands ,Pregnancy ,Risk Factors ,medicine ,Prevalence ,Humans ,030212 general & internal medicine ,Prospective Studies ,Risk factor ,Prospective cohort study ,Psychiatric Status Rating Scales ,030219 obstetrics & reproductive medicine ,Obstetrics ,business.industry ,Depression ,Stressor ,Public Health, Environmental and Occupational Health ,medicine.disease ,Edinburgh Postnatal Depression Scale ,Cohort ,Female ,business ,Postpartum period ,Perinatal Depression - Abstract
The aim of the study was to document perinatal depression in mothers in the Maldives and associated factors. A cohort of 458 mothers was recruited at the 2 major hospitals in Malé, the Maldives, and followed from 36 weeks of pregnancy to 3 months after birth. The Edinburgh Postnatal Depression Scale (EPDS) was used to measure maternal depression. Maternal sociodemographic factors and infant’s health were also recorded. The prevalence of depressive symptoms (EPDS score ≥13) at 36 weeks of pregnancy and at 1 and 3 months postpartum were 24%, 27%, and 12%, respectively. Having experienced stressful life events is an established risk factor for maternal depression across these time points. Having depressive symptoms during the postpartum period is significantly associated with presence of antenatal depressive symptoms. Future studies may look into effectiveness of strategies that cope with stressors in the management of maternal depression.
- Published
- 2018
31. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
- Author
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Sena Bluemel, Cristina Llorente, Karen E. Nelson, David A. Brenner, Rohit Loomba, Patrick M. Gillevet, Jun Xu, Derrick E. Fouts, Hui J. Wang, Masoumeh Sikaroodi, Tatsuo Inamine, Henrik Toft Sørensen, Jessica DePew, Samuel B. Ho, Bernd Schnabl, Xin Du, Tatiana Kisseleva, Peter Uhd Jepsen, Jasmohan S. Bajaj, Hendrik Vilstrup, Mitchell L. Schubert, and Lirui Wang
- Subjects
Alcoholic liver disease ,medicine.medical_specialty ,Science ,General Physics and Astronomy ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,Oral and gastrointestinal ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,lcsh:Science ,Multidisciplinary ,biology ,business.industry ,Liver Disease ,General Chemistry ,medicine.disease ,biology.organism_classification ,Publisher Correction ,Enterococcus ,030220 oncology & carcinogenesis ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Gastric acid ,030211 gastroenterology & hepatology ,lcsh:Q ,business ,Digestive Diseases - Abstract
In the original PDF version of this Article, which was published on 16 October 2017, the publication date was incorrectly given as 10 October 2017. This has now been corrected in the PDF; the HTML version of the paper was correct from the time of publication.
- Published
- 2017
32. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
- Author
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Sena Bluemel, Samuel B. Ho, Patrick M. Gillevet, Karen E. Nelson, Jun Xu, Masoumeh Sikaroodi, Derrick E. Fouts, Hendrik Vilstrup, Cristina Llorente, Jessica DePew, Xin Du, Peter Uhd Jepsen, Lirui Wang, Hui J. Wang, David A. Brenner, Mitchell L. Schubert, Tatiana Kisseleva, Bernd Schnabl, Tatsuo Inamine, Jasmohan S. Bajaj, Rohit Loomba, and Henrik Toft Sørensen
- Subjects
Male ,0301 basic medicine ,Alcoholic liver disease ,Cirrhosis ,General Physics and Astronomy ,Pharmacology ,Inbred C57BL ,Chronic liver disease ,Oral and gastrointestinal ,Hepatitis ,Alcohol Use and Health ,Substance Misuse ,Mice ,Liver disease ,0302 clinical medicine ,Non-alcoholic Fatty Liver Disease ,2.1 Biological and endogenous factors ,Aetiology ,lcsh:Science ,Multidisciplinary ,Liver Disease ,Incidence ,Liver Diseases ,Microbiota ,Fatty liver ,Alcoholic ,3. Good health ,Intestines ,Alcoholism ,Liver ,Biochemistry ,Disease Progression ,Female ,030211 gastroenterology & hepatology ,medicine.drug_class ,Science ,Chronic Liver Disease and Cirrhosis ,Proton-pump inhibitor ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,Gastric Acid ,03 medical and health sciences ,Genetics ,Journal Article ,medicine ,Animals ,Humans ,Liver Diseases, Alcoholic ,Proton Pump Inhibitors ,General Chemistry ,medicine.disease ,Good Health and Well Being ,030104 developmental biology ,Gastric acid ,lcsh:Q ,Steatohepatitis ,Digestive Diseases ,Enterococcus - Abstract
Chronic liver disease is rising in western countries and liver cirrhosis is the 12th leading cause of death worldwide. Simultaneously, use of gastric acid suppressive medications is increasing. Here, we show that proton pump inhibitors promote progression of alcoholic liver disease, non-alcoholic fatty liver disease, and non-alcoholic steatohepatitis in mice by increasing numbers of intestinal Enterococcus spp. Translocating enterococci lead to hepatic inflammation and hepatocyte death. Expansion of intestinal Enterococcus faecalis is sufficient to exacerbate ethanol-induced liver disease in mice. Proton pump inhibitor use increases the risk of developing alcoholic liver disease among alcohol-dependent patients. Reduction of gastric acid secretion therefore appears to promote overgrowth of intestinal Enterococcus, which promotes liver disease, based on data from mouse models and humans. Recent increases in the use of gastric acid-suppressive medications might contribute to the increasing incidence of chronic liver disease., Proton pump inhibitors (PPIs) reduce gastric acid secretion and modulate gut microbiota composition. Here Llorente et al. show that PPIs induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice and humans.
- Published
- 2017
33. Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism
- Author
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William R. Lagor, Chang Seok Lee, Dimitra K. Georgiou, Hui J. Wang, Robert T. Dirksen, Robia G. Pautler, Deric M. Griffin, Adan Dagnino-Acosta, and Susan L. Hamilton
- Subjects
CD36 Antigens ,Male ,medicine.medical_specialty ,Calcium Channels, L-Type ,CD36 ,Mice, Transgenic ,environment and public health ,Biochemistry ,Mice ,chemistry.chemical_compound ,Cav1.1 ,Ca2+/calmodulin-dependent protein kinase ,Internal medicine ,medicine ,Animals ,Muscle, Skeletal ,Molecular Biology ,chemistry.chemical_classification ,Muscle fatigue ,biology ,Fatty acid metabolism ,musculoskeletal, neural, and ocular physiology ,Calcium channel ,Fatty Acids ,Skeletal muscle ,Fatty acid ,Cell Biology ,Mitochondria, Muscle ,Endocrinology ,medicine.anatomical_structure ,nervous system ,chemistry ,cardiovascular system ,biology.protein ,Calcium ,Nitric Oxide Synthase ,Calcium-Calmodulin-Dependent Protein Kinase Type 2 ,Energy Metabolism ,tissues ,Oxidation-Reduction ,Signal Transduction - Abstract
Ca(2+) permeation and/or binding to the skeletal muscle L-type Ca(2+) channel (CaV1.1) facilitates activation of Ca(2+)/calmodulin kinase type II (CaMKII) and Ca(2+) store refilling to reduce muscle fatigue and atrophy (Lee, C. S., Dagnino-Acosta, A., Yarotskyy, V., Hanna, A., Lyfenko, A., Knoblauch, M., Georgiou, D. K., Poché, R. A., Swank, M. W., Long, C., Ismailov, I. I., Lanner, J., Tran, T., Dong, K., Rodney, G. G., Dickinson, M. E., Beeton, C., Zhang, P., Dirksen, R. T., and Hamilton, S. L. (2015) Skelet. Muscle 5, 4). Mice with a mutation (E1014K) in the Cacna1s (α1 subunit of CaV1.1) gene that abolishes Ca(2+) binding within the CaV1.1 pore gain more body weight and fat on a chow diet than control mice, without changes in food intake or activity, suggesting that CaV1.1-mediated CaMKII activation impacts muscle energy expenditure. We delineate a pathway (Cav1.1→ CaMKII→ NOS) in normal skeletal muscle that regulates the intracellular distribution of the fatty acid transport protein, CD36, altering fatty acid metabolism. The consequences of blocking this pathway are decreased mitochondrial β-oxidation and decreased energy expenditure. This study delineates a previously uncharacterized CaV1.1-mediated pathway that regulates energy utilization in skeletal muscle.
- Published
- 2015
34. Abstract 463: The Key Regulatory Elements for SM22 Transcription
- Author
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Maozhou Yang, Soren Warming, Jianbin Shen, Hong Jiang, Hui J Li, Steve Krawetz, and Li Li
- Subjects
Cardiology and Cardiovascular Medicine - Abstract
Gene transcription is controlled by an array of transcriptional regulatory elements. SM22 gene regulation has been widely used to characterize the molecular mechanisms of smooth muscle cell (SMC) phenotypic modulation during cardiovascular development and in vascular diseases. Our previous studies show that the proximal CArG box (CArGnear) in the SM22 promoter is required for its transcription in arterial smooth muscle cells (SMC). However, the role of the CArG box in visceral SMCs has not yet been explored. Here we aim to determine the role of CArG boxes in regulating S M22 transcription in both vascular and visceral SMCs. Using bacterial chromosome (BAC) recombineering, we knock-in a lacZ reporter into a SM22 BAC to trace SM22 transcriptional activities in transgenic mice. Anatomic/histology analyses show that the lacZ expression patterns in the BAC transgenic mice recapitulate that of the endogenous SM22 transcription during embryogenesis and in adult . Similar to the endogenous SM22 regulation, the expression of lacZ is highly sensitive to vascular remodeling: carotid injury abolishes lacZ expression in the arterial wall. Using seamless BAC recombineering mutagenesis, we generate mutations in the proximal and/or distal CArG box in the SM22-lacZ-BAC. Consistent with our previous results, we find that mutating the CArGnear box disrupts the lacZ expression in the aorta; this mutation also drastically reduces its expression in visceral SMCs including stomach, uterus and bladder. Interestingly, mutating the distal CArG (CArGfar) box does not affect the lacZ expression in arterial, venous and visceral SMCs. Mutating both CArG boxes nearly abolishes lacZ expression in all SMCs. This study provides evidence supporting the generation of SM22 knockout mice by mutating the CArG boxes in the SM22 promoter using the CRISPR technology.
- Published
- 2017
35. A dissociation between renewal and contextual fear conditioning in juvenile rats
- Author
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Despina E. Ganella, Chun Hui J. Park, and Jee Hyun Kim
- Subjects
Male ,Dissociation (neuropsychology) ,Conditioning, Classical ,Contextual fear ,Developmental psychology ,Extinction, Psychological ,Rats, Sprague-Dawley ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Developmental Neuroscience ,Developmental and Educational Psychology ,Juvenile ,Animals ,0501 psychology and cognitive sciences ,050102 behavioral science & comparative psychology ,Prefrontal cortex ,Cued speech ,Maternal deprivation ,Age differences ,Behavior, Animal ,05 social sciences ,Fear ,Rats ,Conditioning ,Psychology ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
We investigated whether juvenile rats do not express renewal following extinction of conditioned fear due to their inability to form a long-term contextual fear memory. In experiment 1, postnatal day (P) 18 and 25 rats received 3 white-noise and footshock pairings, followed by 60 white-noise alone presentations the next day. When tested in a different context to extinction, P25 rats displayed renewal whereas P18 rats did not. Experiments 2A and 2B surprisingly showed that P18 and P25 rats do not show differences in contextual and cued fear, regardless of the conditioning-test intervals and the number of white-noise-footshock pairings received. Finally, we observed age differences in contextual fear when P25 rats were weaned at P21 in experiment 3. These results indicate that the developmental dissociation observed in renewal of extinguished fear is not related to the widely believed late emergence of contextual fear learning.
- Published
- 2017
36. Factors Associated with Pressure Ulcer Risk in Spinal Cord Injury Rehabilitation
- Author
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Gerben DeJong, Patrick Brown, Randall J. Smout, Tara Bouchard, Pamela H. Ballard, Ching-Hui J. Hsieh, and Susan D. Horn
- Subjects
Adult ,Male ,Rehabilitation hospital ,medicine.medical_specialty ,medicine.medical_treatment ,Physical Therapy, Sports Therapy and Rehabilitation ,Rehabilitation Centers ,Severity of Illness Index ,Cohort Studies ,Young Adult ,Hospitals, Urban ,Injury Severity Score ,Predictive Value of Tests ,Risk Factors ,Severity of illness ,medicine ,Humans ,Prospective Studies ,Prospective cohort study ,Spinal cord injury ,Physical Therapy Modalities ,Spinal Cord Injuries ,Pressure Ulcer ,Rehabilitation ,Preexisting Condition Coverage ,business.industry ,Incidence ,Age Factors ,Length of Stay ,Middle Aged ,medicine.disease ,Functional Independence Measure ,Treatment Outcome ,Physical therapy ,Female ,business ,Follow-Up Studies ,Cohort study - Abstract
Objective The aim of this study was to identify patient and clinical factors most strongly associated with a spinal cord injury patient's risk for developing a pressure ulcer (PU) during rehabilitation. Design This is a prospective observational cohort study conducted at an urban rehabilitation hospital-based specialized spinal cord injury center. The main outcome measure was the onset of a stage 2 or higher PU. Results Study patients (N = 159) with new (n = 66) and patients with earlier (n = 99) spinal injuries had identical rates at which they acquired a new PU (stage ≥2) in rehabilitation--13.1%. The patients who came to rehabilitation with a PU or myocutaneous flap exhibited a higher rate of developing yet another PU while in rehabilitation (30.2%) than those who came to rehabilitation without an existing PU or flap (6.9%). Logistic regression analysis identified two variables that best predicted a patient's risk at admission for developing a PU during rehabilitation (c = 0.77)--entering rehabilitation with a PU and admission Functional Independence Measure transfers score of less than 3.5. Conclusions The greatest risk of developing a new PU in rehabilitation is being admitted with an existing PU followed by admission Functional Independence Measure transfers score of less than 3.5. Using these two variables, one can develop a patient PU risk algorithm at admission that can alert clinicians for the need to enhance vigilance, skin monitoring, and early patient education.
- Published
- 2014
37. Comparison of volatile compounds of hot‐pressed, cold‐pressed and solvent‐extracted flaxseed oils analyzed by SPME‐GC/MS combined with electronic nose: Major volatiles can be used as markers to distinguish differently processed oils
- Author
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Hui J. Zhang, Ya Y. Xu, Wan P. Xi, Wen Y. Liu, Dong Cao, Chang Q. Wei, Ming Ding, Ke X. Huang, and Lu Chen
- Subjects
Hexanoic acid ,Chromatography ,Electronic nose ,biology ,Nonanal ,Ethyl acetate ,General Chemistry ,biology.organism_classification ,Hexanal ,Sensory analysis ,Industrial and Manufacturing Engineering ,Acetic acid ,chemistry.chemical_compound ,chemistry ,Aroma ,Food Science ,Biotechnology - Abstract
Analysis of volatile profiles from differently processed flaxseed oils (FSO) was performed by SPME-GC-MS, electronic nose (E-nose) and descriptive sensory analysis. A total of 61 volatiles were tentatively identified and then quantified. Among these components, 51 volatiles were obtained from the hot-pressed FSO, 47 from cold-pressed FSO, and 40 by solvent extraction. Principal component analysis (PCA) demonstrated that three FSO samples tested resulted in significant differences of three treatments (p
- Published
- 2014
38. Serum Myostatin Levels are Elevated in Overweight Patients
- Author
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Hong B. Yang, Xiang Q. Wang, Hui Pan, Hui J. Zhu, Lin J. Wang, Nai S. Li, Dian X. Zhang, and Feng Y. Gong
- Subjects
medicine.medical_specialty ,Waist ,Adiponectin ,biology ,business.industry ,Endocrinology, Diabetes and Metabolism ,Myostatin ,Overweight ,Body weight ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Negatively associated ,Internal medicine ,Internal Medicine ,biology.protein ,Uric acid ,Medicine ,medicine.symptom ,business ,Serum adiponectin - Abstract
Objective: Myostatin has recently been proposed as an important factor that not only regulates skeletal muscle mass, but also body fat mass. The aim of our study is to explore serum myostatin levels in overweight patients and its association with metabolic-related characteristics. Methods: 40 overweight patients and 40 normal weight controls were recruited, and serum myostatin were measured by ELISA methods and the relationships between myostatin and metabolic-related parameters were investigated. Results: Serum myostatin concentrations were significantly increased in overweight patients compared with normal weight controls (10.99±1.99 vs. 9.75±0.96 ng/ml, P=0.001) and positively correlated with body weight (r = 0.272, P=0.015), BMI (r = 0.263, P=0.018), waist circumference (r = 0.291, P=0.009), hip circumference (r = 0.336, P=0.002) and TNF-α (r = 0.611, P Conclusion: Serum myostatin levels in overweight patients are notably increased and positively correlated with BMI, body weight, waist and hip circumference, TNF-α, suggesting myostatin is a metabolic regulatory factor.
- Published
- 2014
39. Ultrashort peptide nanofibrous hydrogels for the acceleration of healing of burn wounds
- Author
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Thiam Chye Lim, Anupama Lakshmanan, Elijah Z. Cai, Chuan-Han Ang, Hui J. Zhou, Yihua Loo, Ashvin Raju, Shabbir Moochhala, Alvin G. Koh, Yong-Chiat Wong, and Charlotte A. E. Hauser
- Subjects
Male ,Models, Molecular ,Materials science ,medicine.medical_treatment ,Nanofibers ,Biophysics ,Bioengineering ,Rats, Sprague-Dawley ,Biomaterials ,Hypertrophic scar ,Dermis ,medicine ,Animals ,Amino Acid Sequence ,Wound Healing ,Debridement ,integumentary system ,Regeneration (biology) ,Hydrogels ,medicine.disease ,Rats ,medicine.anatomical_structure ,Mechanics of Materials ,Nanofiber ,Self-healing hydrogels ,Ceramics and Composites ,Epidermis ,Burns ,Wound healing ,Oligopeptides ,Biomedical engineering - Abstract
There is an unmet clinical need for wound dressings to treat partial thickness burns that damage the epidermis and dermis. An ideal dressing needs to prevent infection, maintain skin hydration to facilitate debridement of the necrotic tissue, and provide cues to enhance tissue regeneration. We developed a class of 'smart' peptide hydrogels, which fulfill these criteria. Our ultrashort aliphatic peptides have an innate tendency to self-assemble into helical fibers, forming biomimetic hydrogel scaffolds which are non-immunogenic and non-cytotoxic. These nanofibrous hydrogels accelerated wound closure in a rat model for partial thickness burns. Two peptide hydrogel candidates demonstrate earlier onset and completion of autolytic debridement, compared to Mepitel(®), a silicone-coated polyamide net used as standard-of-care. They also promote epithelial and dermal regeneration in the absence of exogenous growth factors, achieving 86.2% and 92.9% wound closure respectively, after 14 days. In comparison, only 62.8% of the burnt area is healed for wounds dressed with Mepitel(®). Since the rate of wound closure is inversely correlated with hypertrophic scar formation and infection risks, our peptide hydrogel technology fills a niche neglected by current treatment options. The regenerative properties can be further enhanced by incorporation of bioactive moieties such as growth factors and cytokines.
- Published
- 2014
40. The management of food cravings and thirst in hemodialysis patients: A qualitative study
- Author
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Mooppil Nandakumar, Junhong Yu, Konstadina Griva, and Hui J Ng
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,030232 urology & nephrology ,Disease ,Thirst ,End stage renal disease ,Interviews as Topic ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Renal Dialysis ,medicine ,Humans ,030212 general & internal medicine ,Everyday life ,Set (psychology) ,Intensive care medicine ,Qualitative Research ,Applied Psychology ,Aged ,Craving ,business.industry ,digestive, oral, and skin physiology ,Disease Management ,Cognition ,Middle Aged ,Self Care ,Kidney Failure, Chronic ,Patient Compliance ,Female ,Hemodialysis ,medicine.symptom ,business ,Clinical psychology ,Qualitative research - Abstract
This study set out to explore the experience of food cravings and thirst, and their management strategies in patients on hemodialysis. Semi-structured interviews with N = 32 hemodialysis patients were analyzed thematically. Findings indicated that food cravings and thirst were common in everyday life of patients and resulted in different emotional responses. A combination of cognitive and behavioral strategies was employed, including avoidance, controlled consumption, and substitution. Self-monitoring and compensatory strategies were also used to prevent or compensate for lapses. These findings lay the groundwork for future work aimed to improve adherence in end-stage renal disease patients.
- Published
- 2014
41. Protective effects of breastfeeding against acute respiratory tract infections and diarrhoea: Findings of a cohort study
- Author
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Raheema Abdul, Raheem, Colin W, Binns, and Hui J, Chih
- Subjects
Adult ,Cohort Studies ,Diarrhea ,Young Adult ,Breast Feeding ,Adolescent ,Surveys and Questionnaires ,Acute Disease ,Humans ,Female ,Respiratory Tract Infections - Abstract
The objective of this paper is to identify associations between breastfeeding and acute respiratory tract infections (ARTIs) and diarrhoea.A cohort of 458 mothers was recruited at the antenatal clinics at Indira Gandhi Memorial and Abdul Rahman Dhon Kaleyfaanu Hospitals. Mothers were interviewed 'face-to-face' at 36 weeks of gestation and at 1, 3 and 6 months after delivery. The questionnaires included demographic information about parents, infant feeding methods and breastfeeding duration. The number of episodes of ARTIs and diarrhoea was also recorded. Ethics approval was obtained from the National Research Committee of the Maldives and Curtin University Human Research Ethics Committee. Descriptive, univariate, logistic and survival analyses were used to assess the effects of breastfeeding on infant ARTIs and diarrhoea.The partial, predominant and exclusive breastfeeding rates at 1 month were 98.9, 67.6 and 26.9%, respectively. The risk of acquiring ARTIs is significantly reduced when the infants were predominantly breastfed for 3 months (adjusted odds ratio (OR): 0.56, 95% of adjusted OR: 0.34-0.94) and 6 months (adjusted OR: 0.45, 95% of adjusted OR: 0.24-0.84). The risk of getting diarrhoea is significantly reduced even when the babies were partially breastfed for 6 months (adjusted OR): 0.31, 95% of adjusted OR: 0.11-0.90). Kaplan Meier curves demonstrated that the risk lowers with longer duration of breastfeeding.Breastfeeding need to be promoted because the risk of infant morbidity is negatively associated with the duration of breastfeeding.
- Published
- 2016
42. Effects of different sutures on fibrosis and wound healing in a rabbit model of corneal wounds
- Author
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Zhi Z. Ma, Ying Li, Hua Zhang, Yun T. Hu, Hui J. Chen, and Jian G. Wu
- Subjects
0301 basic medicine ,Cancer Research ,Pathology ,medicine.medical_specialty ,H&E stain ,Vimentin ,wound healing ,Biology ,sutures ,Extracellular matrix ,03 medical and health sciences ,Collagen Type III ,0302 clinical medicine ,Immunology and Microbiology (miscellaneous) ,Fibrosis ,Cornea ,cornea ,medicine ,integumentary system ,fibrosis ,General Medicine ,Articles ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,030221 ophthalmology & optometry ,biology.protein ,Wound healing ,Myofibroblast - Abstract
The aim of the study was to investigate wound healing and scar formation in rabbit corneal lamellar wounds repaired with simple interrupted sutures (SIS) or horizontal mattress sutures (HMS). Two parallel 'I'-shaped lamellar cornea wounds were created in one eye of 40 white New Zealand rabbits, while 5 uninjured rabbits were sacrificed to serve as normal controls. One side of the wounds, in the test rabbits, was closed with SIS, while the other side was treated with HMS. Ten days later, the stitches were removed under anesthesia. The animals were sacrificed on days 14 and 21, and months 3 and 6 after the suturing surgery, and corneal samples were subjected to histological and immunofluorescent studies: α-smooth muscle actin (α-SMA) and vimentin were used to detect myofibroblasts and fibroblasts, respectively, and collagen type I and III was used to detect extracellular matrix (ECM) deposition. Relevant mRNA levels were assessed by quantitative polymerase chain reaction (qPCR) to elucidate the differences in wound healing and formation of fibrosis. Macroscopic and hematoxylin and eosin staining observations showed that the two sides of the wounds developed the most prominent fibrotic tissue on day 21. The immunofluorescence and qPCR results showed that HMS wounds produced increased α-SMA, vimentin and collagen type III compared to the SIS wounds on day 14 or 21. The collagen type I expression showed no distinctive difference in SIS and HMS wounds. In conclusion, corneal lamellar wounds treated with SIS developed less fibrotic-related proteins and related mRNA in the early stages of wound healing than wounds treated with HMS. Although differences were not distinct after 3 months, the results of the present study suggest a benefit in choosing SIS over HMS, as at least the initial fibrotic process seems more benign with SIS. Corneal wounds should be carefully sutured, ensuring the tissue is well aligned.
- Published
- 2016
43. Addition of enzymes complex during olive oil extraction improves oil recovery and bioactivity of Western Australian Frantoio olive oil
- Author
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Hui J. Chih, Anthony P. James, Vijay Jayasena, and Satvinder S. Dhaliwal
- Subjects
chemistry.chemical_classification ,Enzyme ,Chromatography ,Chemistry ,Extraction (chemistry) ,Olive oil extraction ,Food science ,Control sample ,Health benefits ,Industrial and Manufacturing Engineering ,Food Science ,Olive oil - Abstract
Summary Olive oil consumption has increased as many studies revealed the health benefits of regular consumption of olive oil. There is a need to find effective oil extraction techniques capable of increasing oil recovery without compromising its quality. This study investigated the impact of adding enzymes complex Viscozymes during olive oil extraction on oil recovery, total phenolic compounds, antiradical activity and the standard quality parameters. It was found that at a concentration of 0.30 g mL−1, Viscozymes could significantly improve the oil recovery from 49 to 69% (P
- Published
- 2012
44. The usefulness of the story recall test in patients with mild cognitive impairment and Alzheimer's disease
- Author
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Jean Y. Chey, SangYun Kim, Hyun Jib Kim, Seoung H. Lee, Hui J. Ryu, YoungHee Chang, Hae R. Na, Seol Heui Han, and Min J. Baek
- Subjects
Male ,medicine.medical_specialty ,Clinical Dementia Rating ,Experimental and Cognitive Psychology ,Neuropsychological Tests ,Audiology ,Verbal learning ,behavioral disciplines and activities ,Discrimination, Psychological ,Alzheimer Disease ,mental disorders ,medicine ,Humans ,Dementia ,Psychiatry ,Aged ,Retrospective Studies ,Aged, 80 and over ,Analysis of Variance ,Korea ,Mini–Mental State Examination ,medicine.diagnostic_test ,Verbal Behavior ,Recall test ,Neuropsychology ,Reproducibility of Results ,Wechsler Adult Intelligence Scale ,Middle Aged ,Verbal Learning ,medicine.disease ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,ROC Curve ,Mental Recall ,Female ,Geriatrics and Gerontology ,Verbal memory ,Cognition Disorders ,Mental Status Schedule ,Psychology ,human activities - Abstract
The story recall test (SRT) is one of the most reliable neuropsychological assessments for evaluating verbal memory function in order to distinguish between individuals with normal aging, mild cognitive impairment (MCI), and Alzheimer's disease (AD). The SRT is analogous to the logical memory test in Wechsler Memory Scale-III, which has recently been developed and standardized to apply to older adults in Korea. The purpose of this study was to examine the usefulness of the SRT and its ability to discriminate between normal cognitive aging and patients with MCI or AD.One hundred and twelve patients with MCI, 97 patients with AD, and 53 healthy elderly adults participated in this study. The SRT was compared with the Clinical Dementia Rating (CDR), Global Deterioration Scale (GDS), Korean version of the Mini Mental State Examination (K-MMSE), and the Korean version of the Hopkins Verbal Learning Test (K-HVLT).The SRT was well-correlated with the dementia rating scales and the K-HVLT. However, the sensitivity and specificity of the SRT was greatly influenced by the level of education of the subjects.The SRT is a sensitive measurement of verbal memory function that can be used in clinical settings to discriminate between normal memory functioning and the very early and moderate stages of AD in a Korean population. Moreover, it is important to recognize that the SRT is more appropriate for subjects with a high level of education rather than a low level of education to differentiate normal cognitive aging from MCI or AD.
- Published
- 2011
45. Enantioselectivity of racemic metolachlor andS-metolachlor in maize seedlings
- Author
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Fei Xie, Wei D. Cai, and Hui J. Liu
- Subjects
Zea mays ,Superoxide dismutase ,chemistry.chemical_compound ,Acetamides ,Botany ,Poaceae ,Peroxidase ,Plant Proteins ,biology ,Herbicides ,Superoxide Dismutase ,Chemistry ,Stereoisomerism ,General Medicine ,Hill reaction ,biology.organism_classification ,Pollution ,Enzyme assay ,Horticulture ,Seedlings ,Seedling ,Catalase ,biology.protein ,Metolachlor ,Food Science - Abstract
Chiral herbicides may have enantioselective effects on plants. In this study, we assessed and compared the enantioselectivity of the chiral herbicides rac-metolachlor and S-metolachlor to maize seedlings. The superoxide dismutase activity (SOD) activity of roots and stem leaves treated by rac-metolachlor was 1.38 and 1.99 times that of roots and stem leaves treated by S-metolachlor. The peroxidase activity (POD) activity of roots and stem leaves was 1.48 and 2.79 times that of roots and stem leaves treated by S-metolachlor, respectively, while the catalase activity (CAT) activity was 4.77 and 8.37 times greater, respectively. The Hill reaction activity of leaves treated by rac-metolachlor were 1.45, 1.33, and 1.14 times those treated by S-metolachlor with treatments of 18.6, 37.2, and 74.4 μM. The differences observed between treatments of rac- and S-metolachlor were significant. Significant differences in maize seedling morphology were also observed between rac- and S-metolachlor treatments. The degradation rate of S-metolachlor in roots was greater than that of rac-metolachlor. The half-lives of rac- and S-metolachlor were 80.6 and 60.3 h at 18.6 μM; 119.5 and 90 h at 37.2 μM; and 169 and 164.8 h at 74.4 μM, respectively. Using the liquid chromatography-mass spectrometry method, hydroxymetolachlor, deschlorometolachlor and deschlorometolachlor propanol were considered to be possible metabolites. We determined the enantioselective toxicity of rac- and S-metolachlor to maize and speculated on the proposed metabolic pathway of metolachlor in maize roots. These results will help to develop an understanding of the proper application of rac- and S-metolachlor in crops, and give some information for environmental safety evaluation of rac- and S-metolachlor.
- Published
- 2010
46. Study of the Effects of Low-Temperature Oxidation on the Chemical Composition of a Light Crude Oil
- Author
-
Qing Y. Yang, Xin Zhang, Yao Lu, Hui J. Wu, and Bin Gui
- Subjects
Alkane ,chemistry.chemical_classification ,Light crude oil ,Chemistry ,General Chemical Engineering ,Energy Engineering and Power Technology ,Hopanoids ,Sterane ,chemistry.chemical_compound ,Fuel Technology ,Environmental chemistry ,Organic chemistry ,Composition (visual arts) ,Chemical composition ,Pyrolysis ,Asphaltene - Abstract
In this study, low-temperature oxidation (LTO) reactions of a light crude oil from the Daqing oil field at 175 and 225 °C were investigated and the changes of the composition and quantity of saturates, aromatics, resins, and asphaltenes (SARA) compounds, n-alkanes, terpanes, and steranes were analyzed, to determine the participation and generation of individual or groups of species in the LTO reactions. Pyrolysis experiments were conducted as a reference for heat effects. The results show that saturates and aromatics are converted to resins and asphaltenes. Both oxidation and heat effects in LTO reactions alter the distribution of n-alkanes, terpanes, and sterane. Oxidation effects cause the predominance of n-alkanes to shift to a lower carbon number, favor hopanes over tricyclic terpanes, and prefer high-molecular-weight steranes to lower molecular-weight ones. The changes of n-alkanes at higher LTO temperatures are controlled by oxidation effects. For terpanes and steranes, heat effects gain dominance a...
- Published
- 2010
47. Effect of short-term culture on functional and stress-related parameters in isolated human islets
- Author
-
Sung Hee Ihm, Jeffrey D. Ansite, Hui J. Zhang, Ippei Matsumoto, and Bernhard J. Hering
- Subjects
endocrine system ,Transplantation ,medicine.medical_specialty ,geography ,geography.geographical_feature_category ,biology ,Edmonton protocol ,Kinase ,p38 mitogen-activated protein kinases ,medicine.medical_treatment ,Islet ,biology.organism_classification ,Hsp70 ,Andrology ,Nude mouse ,Endocrinology ,Internal medicine ,Gene expression ,medicine - Abstract
The Edmonton protocol for islet transplantation utilizes fresh islet grafts but other protocols increasingly transplant short-term cultured grafts mainly for practical reasons. To improve our understanding of the impact of culture pretreatment of human islets, we assessed post-transplant function by nude mouse bioassay, islet ATP, activity of stress-activated MAP kinases, and expression of stress-related genes by focused cDNA array in freshly isolated and cultured islets. Mean blood glucose levels over 4 weeks after transplantation (2000 IE) of (i) freshly isolated, (ii) cultured and preculture counted (recovery rate; 78 +/- 6%), and (iii) cultured and postculture counted islets in diabetic mice were 330 +/- 40, 277 +/- 65, and 256 +/- 52 mg/dl (i versus ii, P = 0.004; i versus iii, P = 0.002). During culture, islet ATP/DNA and ATP/ADP increased; JNK and p38 MAPK activities decreased. Among 96 genes studied, mRNA expression of heat shock protein 70 genes decreased >twofold during culture in all four pairs; expression of cyclooxygenase-2, superoxide dismutase-2, interleukin-6 and cytochromes P450 1A1 genes increased. Our results show that culturing human islets before transplantation is not disadvantageous in regard of functional recovery from changes induced by nonphysiologic stimuli during islet isolation. The increase in expression of several stress-related genes during culture also shows that improving culture conditions may further enhance post-transplant islet function.
- Published
- 2008
48. Towards a physical XML independent XQuery/SQL/XML engine
- Author
-
Thomas Baby, Hui J. Chang, Zhen Hua Liu, and Sivasankaran Chandrasekar
- Subjects
Document Structure Description ,SQL ,XML Encryption ,Relational database ,computer.internet_protocol ,Computer science ,Efficient XML Interchange ,XML Signature ,Relational algebra ,computer.software_genre ,SQL/XML ,Oracle ,Simple API for XML ,Relational database management system ,XML Schema Editor ,Schema (psychology) ,Streaming XML ,RELAX NG ,Binary XML ,XML schema ,SGML ,computer.programming_language ,Database ,General Engineering ,InformationSystems_DATABASEMANAGEMENT ,XML validation ,computer.file_format ,XML framework ,XQuery ,XML Schema (W3C) ,XML database ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Tuple ,computer ,XML ,XML Catalog - Abstract
There has been a lot of research and industrial effort on building XQuery engines with different kinds of XML storage and index models. However, most of these efforts focus on building either an efficient XQuery engine with one kind of XML storage, index, view model in mind or a general XQuery engine without any consideration of the underlying XML storage, index and view model. We need an underlying framework to build an XQuery engine that can work with and provide optimization for different XML storage, index and view models. Besides XQuery, RDBMSs also support SQL/XML, a standard language that integrates XML and relational processing. There are industrial efforts for building hybrid XQuery and SQL/XML engines that support both languages so that users can manage and query both relational and XML data on one platform. However, we need a theoretical framework to optimize both SQL/XML and XQuery languages in one RDBMS. In this paper, we show our industrial work of building a combined XQuery and SQL/XML engine that is able to work and provide optimization for different kinds of XML storage and index models in Oracle XMLDB. This work is based on XML extended relational algebra as the underlying tuple-based logical algebra and incorporates tree and automata based physical algebra into the logical tuple-based algebra so as to provide optimization for different physical XML formulations. This results in logical and physical rewrite techniques to optimize XQuery and SQL/XML over a variety of physical XML storage, index and view models, including schema aware object relational XML storage with relational indexes, binary XML storage with schema agnostic path-value-order key XMLIndex, SQL/XML view over relational data and relational view over XML. Furthermore, we show the approach of leveraging cost based XML physical rewrite strategy to evaluate different physical rewrite plans.
- Published
- 2008
49. β1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts
- Author
-
Chong J. Park, Catherine C. Park, Mina J. Bissell, Evelyn Yao, and Hui J. Zhang
- Subjects
Cancer Research ,Blotting, Western ,Transplantation, Heterologous ,Apoptosis ,Breast Neoplasms ,Cell Separation ,Biology ,Article ,Cell Line ,chemistry.chemical_compound ,In vivo ,In Situ Nick-End Labeling ,medicine ,Humans ,Breast ,Protein kinase B ,Cell Proliferation ,Microscopy, Confocal ,Cell growth ,Integrin beta1 ,Cancer ,medicine.disease ,Molecular biology ,Treatment Outcome ,Oncology ,chemistry ,Cancer cell ,Signal transduction ,Growth inhibition - Abstract
β1 Integrin signaling has been shown to mediate cellular resistance to apoptosis after exposure to ionizing radiation (IR). Other signaling molecules that increase resistance include Akt, which promotes cell survival downstream of β1 integrin signaling. We previously showed that β1 integrin inhibitory antibodies (e.g., AIIB2) enhance apoptosis and decrease growth in human breast cancer cells in three-dimensional laminin-rich extracellular matrix (lrECM) cultures and in vivo. Here, we asked whether AIIB2 could synergize with IR to modify Akt-mediated IR resistance. We used three-dimensional lrECM cultures to test the optimal combination of AIIB2 with IR treatment of two breast cancer cell lines, MCF-7 and HMT3522-T4-2, as well as T4-2 myr-Akt breast cancer colonies or HMT3522-S-1, which form normal organotypic structures in three-dimensional lrECM. Colonies were assayed for apoptosis and β1 integrin/Akt signaling pathways were evaluated using Western blot. In addition, mice bearing MCF-7 xenografts were used to validate the findings in three-dimensional lrECM. We report that AIIB2 increased apoptosis optimally post-IR by down-regulating Akt in breast cancer colonies in three-dimensional lrECM. In vivo, addition of AIIB2 after IR significantly enhanced tumor growth inhibition and apoptosis compared with either treatment alone. Remarkably, the degree of tumor growth inhibition using AIIB2 plus 2 Gy radiation was similar to that of 8 Gy alone. We previously showed that AIIB2 had no discernible toxicity in mice; here, its addition allowed for a significant reduction in the IR dose that was necessary to achieve comparable growth inhibition and apoptosis in breast cancer xenografts in vivo. [Cancer Res 2008;68(11):4398–405]
- Published
- 2008
50. A MICROCALORIMETRIC METHOD TO STUDY THE EFFECT OF KANAMYCIN ON THE METABOLISM OF RECOMBINANTESCHERICHIA COLI
- Author
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Xiao X. Ma, Yu Mi, Li H. Wang, Long A. Shang, Li F. Gu, Kang Z. Xu, Hui J. Shi, and Dai D. Fan
- Subjects
Isothermal microcalorimetry ,Recombinant escherichia coli ,Chemistry ,General Chemical Engineering ,Kanamycin ,General Chemistry ,Metabolism ,biochemical phenomena, metabolism, and nutrition ,Bacterial growth ,law.invention ,Biochemistry ,Stationary phase ,law ,medicine ,Recombinant DNA ,bacteria ,IC50 ,medicine.drug - Abstract
A microcalorimetric technique based on the metabolic heat production from cultured cells was used to investigate the effect of kanamycin on the growth and metabolism of recombinant Escherichia coli. Power-time curves of growing recombinant Escherichia coli cell suspensions treated with different kanamycin doses were recorded and were described very accurately by the generalized logistic equation. The rate constant (k) is kanamycin concentration-dependent and the relationship between k and C (kanamycin dose) is nearly linear. The 50% inhibitory concentration IC50 was 88.49 µg/mL. The experimental results revealed that high doses of kanamycin inhibited the growth of recombinant E. coli during the log phase and promoted growth during the stationary phase. These results are important for deciding the optimum kanamycin dose for the maximal synthesis of human-like collagen.
- Published
- 2007
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