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With the rapid development of Internet technology, online education has become a development trend of educational technology in China.Mixed teaching is an emerging teaching mode that combines computer technology with traditional teaching activities. Mixed teaching is a learning method that combines the advantages of offline teaching and online teaching to realize the complementary advantages.The teaching work in the new era promotes the development of online teaching mode. On this basis, we can try to build a hybrid online and offline teaching mode In the deep integration and development of education and Internet technology, students have adapted to use the Internet to find information to acquire knowledge, through the construction and use of network teaching platform, teachers can greatly promote the innovation of teaching methods and mobilize the enthusiasm of students, so as to improve students’ learning interest and innovation ability Based on the new development strategy and educational policy, "Curriculum Ideology" is integrated into the teaching of professional courses.This is a new concept for ideological and political education in colleges and universities in recent years. According to the spirit and requirements of the CPC Central Committee and relevant ministries and commissions on strengthening ideological and political education in schools, it is to develop and utilize the ideological and political education resources of relevant courses, so as to give full play to the ideological and political education functions contained in all courses.In this paper, through the online survey and data analysis, the mixed teaching mode in mathematics teaching is investigated and studied, and the application of Massive Open Online Courses (MOOC) teaching and internet education technology is analyzed by taking the course Probability Theory and Mathematical Statistics as an example. The mixed online and offline teaching mode is adopted in the teaching of Probability Theory and Mathematical Statistics, students participate in teaching in the whole process, fully reflecting the dominant position of students and the guiding role of teachers. Although teaching is impermanent, teaching methods can be improved and explored. First of all, teachers assign online learning tasks to students based on problem orientation. Students choose their own teachers to provide online learning materials or mooc of Chinese universities for online learning. Secondly, teachers and students interact with each other to complete the task of teaching and learning when offline teaching. Finally, through the general after-school assignments and project assignments to examine the students to master the content of the new course and cultivate students’ ability to solve practical problems. In this process, by introducing the online learning process of MOOC, students’ learning initiative and self-adaptability can be better promoted so as to achieve the purpose of making every student have development in the knowledge of Probability Theory and Mathematical Statistics.

Figure S1 Representative immunohistochemical staining for AHR intracellular distribution. Depending on the status of AHR expression and the availability of AHR ligands, which is presumably different among cells, AHR ligands would bind to cytoplasmic AHR for its activation and nuclear translocation dynamically. Compared with the normal AHRcKO which had little AHR immunoreactivity (B), the normal AHRflx/flx (A) showed predominantly nuclear distribution of AHR immunoreactivity, and to a lesser extent in the cytoplasm in Iba1-positive and Iba-1 negative cells. Figure S2 The expression levels of 84 candidate genes and 5 housekeeping genes from the ipsilesional hemisphere by neurogenesis array. (A) The array data obtained by real-time polymerase chain reaction (RT-PCR). Changes beyond 1 ± 0.5-fold are shown as differentially expressed genes. The WT-Vehicle group show the upregulated gene expression of S100β, Cxcl1, Bmp2, Tgfβ1, Odz1 and downregulated Mef2c, Ngn2 and Ngn1 at 48 h after MCAO. In contrast, the WT-TMF group downregulated the gene expression of S100β, Cxcl1, Bmp2, Tgfβ1, and Odz1 and upregulated Mef2c, Ngn2 and Ngn1 compared with vehicle treatment after MCAO. (B) On the other hand, in the AhRflx/flx group, upregulated S100β and Cxcl1 gene expression was observed after MCAO. In AhRcKO mice, downregulated S100β and Cxcl1 and upregulated Ngn2, Nr2e3 and Cdk5rap2 gene expression were noted compared with the AhRflx/flx group after MCAO (n = 3/each group). (C) In summary of the 84 gene expression regulation, the common changes by pharmacological inhibition (TMF, marked in blue) and AhRcKO mice (marked in pink) were S100β, Cxcl1, Ngn2, and Ngn1 (marked in purple). #p

For on-site clinical diagnosis of biomolecules, the detection performances of most point-of-care (POC) biosensor devices are limited by undesired cross-detection of other non-analyte proteins in patient serum samples and other complex samples. To conquer this obstacle, this work presents a fully integrated bottom-gate poly-silcion nanowire (polySi NW) biosensor system-on-chip (SoC) to enhance the detection performance of cardiac-specific troponin-I (cTnI) concentration levels in serum samples. By applying proper electrical potential at the bottom gate under polySi NW biosensor, the biosensor response to cTnI biomarker can be improved by at least 16 fold in 50% phantom serum samples. The experimental result shows its detection range is from 3.2 × 10 − 13 M ( mol l − 1 ) to 3.2 × 10 − 10 M . This enhancement can be attributed to the electrostatic interactions between target biomolecules and voltage-applied bottom gate electrodes. This is the first time that a polySi NW CMOS biosensor chip has shown feasibilities to detect specific biomarkers in serum samples. Therefore, the developed technology paves the way toward on-field applications of CMOS compatible SiNW biosensing technologies and it can be employed for future biomolecular analysis in on-site serum diagnosis applications.

HUANG Yu-jie, the famous TCM physician of Taiwan in the late Qing dynasty and early Republican period of China, was a physician with noble medical morality and perfect medical skill. He made distinguished contributions especially to the prevention and treatment of epidemic disease. During the time he undertook the medical work, he also actively took part in the social activities and made changes in customs and traditions to promote the development of society. His medical morality and skill not only were the model for the medical field at that time but also had an extensive and profound impact on the common people.