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Additional file 2: Table S1. Lack of 2 weeks improvement cut-offs as predictors of nonresponse to antipsychotics at endpoint.

Additional file 4: Table S3. Lack of 2 weeks improvement cut-offs as predictors of nonresponse in four antipsychotics.

Additional file 5: Table S4. Lack of 4 weeks improvement cut-offs as predictors of nonresponse in four antipsychotics.

Additional file 1. CONSORT checklist. The CONSORT checklist for reporting a randomized trial.

Additional file 3: Table S2. Lack of 4 weeks improvement cut-offs as predictors of nonresponse to antipsychotics at endpoint.

© 2014 Elsevier B.V. As an important part of a transition zone surrounding a lake, lakeshore plays a critical role in connecting hydrology and biochemistry between surface water and groundwater. The shape, slope, subsurface features, and seepage face of a lakeside slope have been reported to affect water and nutrient exchange and consequently the water quality of near-shore lake water. Soil tank experiments and Hydrus-2D model simulations were conducted to improve our understanding of the influence of slope revetment materials (SRMs) on water flow and solute transport in a lakeshore zone. The low hydraulic conductivity of SRMs affected flow patterns in the lakeshore zone and resulted in a local increase of the groundwater table near the slope face. Water and solute flux distributions on the slope face under bare-slope conditions followed an exponential function. Fluxes were concentrated within a narrow portion of the slope surface near the intersection point between the lake water level and the slope face. Surface pollutants (for example from fishponds and paddy fields surrounding a lake) were transported into the lake along shallow groundwater through both unsaturated and saturated zones. The SRMs on the slope face affected the ratio of water and solute fluxes in the unsaturated zone, increasing along with the decline of the hydraulic conductivity of SRMs. Furthermore, as the hydraulic conductivity of SRMs decreased, the retention time and the potential for oxygen reduction correspondingly increased, which affected the nitrogen transport and transformations in the lakeshore zone. Simulated and experimental results indicate that if concrete along the shoreline of Lake Taihu is replaced with a relatively high-conductivity lime or the slope is left bare, water fluxes will increase less than solute fluxes, which will rise significantly, in particular in the unsaturated zone and along the seepage face. On the other hand, the largest water and solute fluxes along the shoreline for the bare and lime-slope conditions will be located higher at the slope than for the concrete-slope conditions. Hydrus-2D provided a good description of complicated hydrodynamic and solute transport/transformation conditions in the lakeshore zone.

This paper discusses an unusual process of helping transform a traditional industry into one that can function in a totally new environment. The industry, traditional Chinese herbal pharmaceutical industry, is extremely “old” and fundamentally different from any pharmaceuticals in the western world. During the contemporary industrial and scientific development, it faces great challenges of entering the new industrial world with western-science paradigms. As one of the main pillars of the Traditional Chinese Medicine (TCM), the Chinese herbal medicine has unique characteristic in that it highlights the balance and interaction of all the ingredients from herbs for each patient, who are treated as an individual with unique prescription of herbal formulation. Following an herbal formulation, the herbal medicine is a cocktail of many herbs tailored to the individual patient. It is prepared by decocting pieces of herbals: The pharmacist weighs out a day's dosage of each herb and combines them in a bag; the crude herbs are boiled in water and then the decoction is ready. This method of preparing herbal medicine has exited in China for thousands of years. However, in nowadays it was challenged by its inaccuracy and randomness as well as its unfitness to modern industrial mess production. Two main solutions appeared in China. One way is to standardize the crude herbs with modern technology and turn them into “prepared drug in pieces”, which is called YINPIAN. The other way is to make batches of herbs into pills or concentrated powdered extracts for some common herbal prescriptions. China is trying to use the western-science paradigms to standardize and industrialize the pharmaceuticals of crude herbs. To limit our analysis, this study focuses on the development of the first way- traditional Chinese pharmaceuticals of YINPIAN. Based on reviewing the scenario of government’s promoting policies on YINPIAN, this paper investigates a case of university-firm collaboration in Southern China (Guangdong) in order to show how academic knowledge is transferred to industry and managed within the government, the university and the firm. Particularly, this paper traces the process of how their innovative YINPIANs are accepted by the modern market and thus the industrial development of YINPIANs is promoted. The findings suggest that incorporating with modern science and technology into a traditional and old industry can “renew” itself and help it enter the new industrial world. To do so, governments, universities and firms are all engines to promote the incorporation by collaboratively managing the knowledge transfer.