Search

Background & aimsThe long-term prognosis of patients with metabolic syndrome (MS) and hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) after radical hepatectomy remains unclear. The purpose of this study was to elucidate the effect of MS on long-term survival for patients with HBV-related HCC after hepatectomy.MethodsPatients with HBV-HCC after hepatectomy were included. Patients were stratified into MS-HBV-HCC and HBV-HCC groups. Clinical features and surgical outcomes were compared between the two groups, and COX regression analysis was used to determine independent risk factors associated with overall survival (OS) and recurrence-free survival (RFS).Result389 patients (MS-HBV-HCC group: n=50, HBV-HCC group: n=339) were enrolled for further analysis. Baseline characteristics showed that patients with MS-HBV-HCC were associated with a high rate of elderly patients, ASA score, and co-morbid illness, but a lower rate of anatomy hepatectomy. There were no significant differences in perioperative complications. After excluding patients who relapsed or died within 90 days after surgery, multivariate Cox regression analysis showed MS was an independent risk factor of OS (HR 1.68, 95% CI 1.05-2.70, P = 0.032) and RFS (HR 1.78, 95% CI 1.24-2.57, P = 0.002).ConclusionMS is an independent risk factor for poor OS and RFS in HBV-infected HCC patients after radical hepatectomy. This suggests that we need to strengthen postoperative follow-up of the relevant population and encourage patients to develop a healthy lifestyle.

Additional file 3: Table S1. Univariable and multivariable Cox-regression analyses of predicting overall survival for patients with resected hepatocellular carcinoma who underwent adjuvant TACE in the developing cohort.

Additional file 2: Table S2. Univariable and multivariable Cox-regression analyses of predicting overall survival for patients with resected hepatocellular carcinoma who did not undergo adjuvant TACE in the developing cohort.

Supplemental material, sj-pdf-1-cmg-10.1177_2631774521993065 for Prognostic factors of resectable perihilar cholangiocarcinoma: a systematic review and meta-analysis of high-quality studies by Lei Liang, Chao Li, Hang-Dong Jia, Yong-Kang Diao, Hao Xing, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Dong-Sheng Huang, Cheng-Wu Zhang and Tian Yang in Therapeutic Advances in Gastrointestinal Endoscopy

Additional file 1. Patients and methods.

Additional file 2: Table S3. The corresponding score and the formula of our nomogram models.

Additional file 2: Figure S2. (A) Kaplan-Meier curves of overall survival between patients in the development and validation cohorts (log-rank test, P = 0.594); (B) Kaplan-Meier curves of overall survival between patients with and without adjuvant TACE in the developing cohort (log-rank test, P < 0.001); and (C) Kaplan-Meier curves of overall survival between patients with and without adjuvant TACE in the validation cohort (log-rank test, P < 0.001). Number of patients at risk and censoring were list in the box at the bottom of each plot.

Additional file 1.

Additional file 2: Figure S1. Flow chart of patient inclusion.

Supplemental material, sj-pdf-1-tag-10.1177_1756284820977693 for Survival benefits from adjuvant transcatheter arterial chemoembolization in patients undergoing liver resection for hepatocellular carcinoma: a systematic review and meta-analysis by Lei Liang, Chao Li, Yong-Kang Diao, Hang-Dong Jia, Hao Xing, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Dong-Sheng Huang, Cheng-Wu Zhang and Tian Yang in Therapeutic Advances in Gastroenterology

The excluded articles and the reasons for exclusion of the articles. (DOC 46 kb)

The pinholes on the surface of alignment layer was studied, which formed during the TFT-LCD manufacturing process and caused defects of the products. Herein, a vitally typical defect, black spot, was analyzed via FIB, SEM and OMS. The analysis results of statistical software BO (Business Objects) show that the pinhole is the main cause of the blackspot. Based on theoretical analysis and further experimental results, it is found that the hydrodynamic in stability of the solution may lead to the pinholes on the alignment layer surface, and the precure time of the alignment film solution is significantly responsible for hydrodynamic instability. It is noteworthy that the instability needs times to grow full enoughand then to influence the film structure. Therefore, the pinholes on the alignment layer surface will be reduced or eliminated if the precure time is less than or equal to that time.