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Human taeniasis caused by tapeworms is an intestinal disease prevalent in many countries around the world. Taenia asiatica, Taenia saginata, and Taenia solium are the most common pathogens causing human taeniasis. Among the three species of tapeworms, T. saginata and T. asiatica share high similarity in their genomes and have been reported to be capable of hybridization with each other. Here, we reported a case of an 18-year-old male patient hospitalized in Yunnan Province, China, in 2019. Due to long-lasting abdominal distension and white tapeworm segments in the feces, the patient was diagnosed with taeniasis. He was treated with traditional Chinese medicine, and a tapeworm approximately 2.7 m long was expelled. The morphology of the eggs and gravid proglottids of the tapeworm was observed. Interestingly, the tapeworm was identified as a hybrid between T. saginata and T. asiatica according to molecular and phylogenetic analyses. This case is the first documented case of human taeniasis caused by a T. saginata and T. asiatica hybrid in Yunnan Province. Molecular evidence suggests that the hybrid of T. saginata and T. asiatica may have caused widespread infection in rural areas of Western China, and further investigation and research on these parasites in Western China are needed. The method described in this case may be helpful for future research.

New COVID-19 epidemic strains like Delta and Omicron with increased transmissibility and pathogenicity emerge and spread across the whole world rapidly while causing high mortality during the pandemic period. Early prediction of possible variants (especially spike protein) of COVID-19 epidemic strains based on available mutated SARS-CoV-2 RNA sequences may lead to early prevention and treatment. Here, combining the advantage of quantum and quantum-inspired algorithms with the wide application of deep learning, we propose a development tool named DeepQuantum, and use this software to realize the goal of predicting spike protein variation structure of COVID-19 epidemic strains. In addition, this hybrid quantum-classical model for the first time achieves quantum-inspired blur convolution similar to classical depthwise convolution and also successfully applies quantum progressive training with quantum circuits, both of which guarantee that our model is the quantum counterpart of the famous style-based GAN. The results state that the fidelities of random generating spike protein variation structure are always beyond 96% for Delta, 94% for Omicron. The training loss curve is more stable and converges better with multiple loss functions compared with the corresponding classical algorithm. At last, evidences that quantum-inspired algorithms promote the classical deep learning and hybrid models effectively predict the mutant strains are strong., Comment: 34 pages, 4 figures, 2 supplementary figures

Additional file 1: Figure S1. SKP2 protein expression in HCC cells. (A) The expressions of SKP2 proteins were reduced in mi-miR26a compared to mi-NC cells in both SNU-387 and Hep3B cell lines. (B) Co-transfected of ov-SKP2 or in-miR26a with sh-lincSCRG1could rescue the depletion of SKP2 protein inducing by sh-lincSCRG1 in 2 cell lines. Figure.S2. Different proteins expression in HCC cells. Sh-lincSCRG1 could down-regulate pro-proliferation related proteins (cyclin D1, CDK4/6) and ETM related proteins (MMPs, N-cadherin and Vimentin), and up-regulate E-cadherin, which could be reversed by co-transfection with ov-SKP2 and in-miR26a in SNU-387 and Hep3B cell lines.

In this thesis we build the parametric mathematical model of machine tool and solid models of traction gears using in subway locomotive by analyzing the machining process of involute gears and meshing principle of involute gears. The optimization design is done through deduce the relations between basic parameters of gear and loading capacity of transmission. On the base of analyzing optimization principles and methods for involute gear system the software is obtained by considering the contact fatigue strength of teeth surface, the bending fatigue strength of root fillet and scuffing strength of teeth surface. It is optimized that the best parameters decide the strength safety and loading capacity by analyzing the optimization results.

On the basis of network establishment, system architecture of warship’s information integral platform and XML distributed data exchange were researched. To focus on information system data and network resource on warship, the multilevel software architecture was adopted in simulation. On the data layer, circulated simulation data about manoeuvring, ship system, power and navigation were got. On the service layer, the software interface of all the simulated systems was supplied, which realized data collection and information storage. The last layer was for user by which human-computer interface was got through client software. To improve stability of ship’s local area network, double-ring topology was used as the main network, and very popular software named Wonderware in field of industry control was developed. With IAS platform, deployment of all the sub-stations was completed, and links between each collection and database were established. Multilevel computer network and information data integration frame on warship had many purpose, such as serving for oriented application system, data communication, information share and so on.

The underwater hovering of submarine is to keep and alter depth at zero speed, which is a complex nonlinear process. Traditional control methods affect the effect because of lacking of adaptive capability, while fuzzy control can solve the problem well. Here the structure of fuzzy controller was set up based on the principle of fuzzy control. Then the rule for hovering control was carried out according to the classic step response. At last, the anti-jamming differentiator was set up by Simulink. The result of two basic working condition simulation showed that fuzzy controller was able to fix the submarine depth well, and had the advantage of fast and robust.

To independently control the depth and trim of the submarine, a fuzzy control method on stern-rudder is proposed, and the advantage of a single stern-rudder in low noise control is elaborated. Taking into account the character of the single stern-rudder, a fuzzy controller is designed. The simulation results have shown that the algorithm has very good control precision, which decreases the rudder and radiated noise greatly.

The existence of seed electrons is the precondition of air breakdown induced by high power microwave (HPM). Seed electrons are usually assumed to exist in background atmosphere when simulating the air breakdown triggered by HPM. However, this assumption may lead to some large errors especially in lower atmosphere where the number of electrons is very small. We establish a physical model of seed electron production from O- detachment collision with air molecules using the Monte Carlo method. A three-dimensional Monte Carlo program is developed to simulate this process. The average energies of O- and the average generation time of seed electrons under different electric intensities, frequencies, air pressures and breakdown volumes are obtained through simulation. The simulations show that the average generation time of seed electrons becomes longer with the increase of air pressure or the HPM frequency. The average seed electron generation time becomes shorter with the increase of electric intensity or breakdown volume. Finally, we simulate the processes of O- detachment collision with air molecules under the same experimental conditions. The comparative results show that the seed electron generation from O- detachment can explain the experimental results when the HPM frequency is low, while at higher frequencies, the average seed electron generation time becomes so long that it cannot correspond to the experimental value. Therefore some other mechanisms should be considered in the higher frequency case.

Fecal samples of 945 dogs were examined microscopically in 2 refuge facilities in China from March 2010 to November 2011. In 8 dogs, oocysts, 9–14 μm in size, were found. Their morphology was similar to those of Hammondia heydorni and Neospora caninum . Sporulated Hammondia / Neospora -like oocysts were fed to 2 dogs, 2 gerbils, 2 guinea pigs, and 2 KM mice; tissues from these inoculated animals were then fed to coccidia-free dogs to determine species susceptibility to these oocysts. Oocysts were not excreted in the feces of dogs or rodents inoculated with oocysts. However, the dogs fed the tissues of gerbils or guinea pigs that were inoculated orally with oocysts excreted fresh oocysts. Dogs fed tissues from guinea pigs inoculated with brain and muscular homogenate from guinea pigs that were fed sporulated Hammondia / Neospora -like oocysts did not excrete oocysts. These findings indicated that the oocysts from naturally infected dogs had an obligatory 2-host life cycle, with gerbils and guinea pigs as intermediate hosts. DNA isolated from these oocysts could not be amplified using N. caninum - and Toxoplasma gondii -specific primers. However, positive amplification with the H. heydorni -specific primers confirmed the presence of H. heydorni DNA in the samples. A comparison of the intron 1 sequence of the alpha tubulin gene with those from H. heydorni from dogs and H. triffittae from foxes showed that dog-derived oocysts possessed a different alpha tubulin gene. Both our dog-derived sequence and 2 previous alpha tubulin gene sequences from H. triffittae from foxes contained a 9-bp insertion relative to 3 sequences of H. heydorni from dogs. However, when the 9-bp insertion from H. triffittae sequences were compared, the 9-bp insertion in our dog-derived sequence had a nucleotide substitution. The present study, therefore, provides new evidence of genetic diversity among isolates from dogs. This is the first survey for H. heydorni in dogs from China.