52 results on '"Hoffmann, U."'
Search Results
2. Allergic manifestation 15 years after early intervention with hydrolyzed formulas – the<scp>GINI</scp>Study
- Author
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von Berg, A., Filipiak-Pittroff, B., Schulz, H., Hoffmann, U., Link, E., Sußmann, M., Schnappinger, M., Brüske, I., Standl, M., Krämer, U., Hoffmann, B., Heinrich, J., Bauer, C.P., Koletzko, S., Berdel, D., and GINIplus Study Group ()
- Subjects
Male ,Pediatrics ,Allergy ,hydrolyzed infant formulas ,nutritional intervention ,0302 clinical medicine ,Odds Ratio ,Prevalence ,randomized trial ,Immunology and Allergy ,Cumulative incidence ,Child ,Incidence ,Incidence (epidemiology) ,Milk Proteins ,15‐year follow‐up from birth ,Infant Formula ,double‐blind ,Milk ,Experimental Allergy and Immunology ,Child, Preschool ,Female ,Original Article ,medicine.medical_specialty ,Adolescent ,Immunology ,15-year Follow-up From Birth ,Allergy Prevention ,Double-blind ,Hydrolyzed Infant Formulas ,Nutritional Intervention ,Randomized Trial ,03 medical and health sciences ,030225 pediatrics ,Hypersensitivity ,medicine ,Animals ,Humans ,Asthma ,allergy prevention ,business.industry ,Infant, Newborn ,Infant ,Odds ratio ,medicine.disease ,Confidence interval ,Patient Outcome Assessment ,030228 respiratory system ,Infant formula ,Spirometry ,Relative risk ,Cattle ,ORIGINAL ARTICLES ,business ,Follow-Up Studies - Abstract
Background Data on the long-term impact of hydrolyzed formulas on allergies are scarce. Objective To assess the association between early intervention with hydrolyzed formulas in high-risk children and allergic outcomes in adolescence. Methods GINI trial participants (n = 2252) received one of four formulas in the first four months of life as breastmilk substitute if necessary: partial or extensive whey hydrolyzate (pHF-W, eHF-W), extensive casein hydrolyzate (eHF-C) or standard cow′s milk formula (CMF) as reference. Associations between these formulas and the cumulative incidence and prevalence of parent-reported physician-diagnosed asthma, allergic rhinitis (AR) and eczema, as well as spirometric indices and sensitization, were examined using generalized linear models. Results Between 11 and 15 years, the prevalence of asthma was reduced in the eHF-C group compared to CMF (odds ratio (OR) 0.49, 95% confidence interval (CI) 0.26–0.89), which is consistent with the spirometric results. The cumulative incidence of AR was lower in eHF-C (risk ratio (RR) 0.77, 95% CI 0.59–0.99]) and the AR prevalence in pHF-W (OR 0.67, 95% CI 0.47–0.95) and eHF-C (OR 0.59, 95% CI 0.41–0.84). The cumulative incidence of eczema was reduced in pHF-W (RR 0.75, 95% CI 0.59–0.96) and eHF-C (RR 0.60, 95% CI 0.46–0.77), as was the eczema prevalence between 11 and 15 years in eHF-C (OR 0.42, 95% CI 0.23–0.79). No significant effects were found in the eHF-W group on any manifestation,nor was there an effect on sensitization with any formula. Conclusion In high-risk children, early intervention using different hydrolyzed formulas has variable preventative effects on asthma, allergic rhinitis and eczema up to adolescence.
- Published
- 2015
3. The External Validity of Prediction Models for the Diagnosis of Obstructive Coronary Artery Disease in Patients With Stable Chest Pain Insights From the PROMISE Trial
- Author
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Genders, TSS, Coles, A, Hoffmann, U, Patel, MR, Mark, DB, Lee, KL, Steyerberg, Ewout, Hunink, Myriam, Douglas, PS, Consortium, CAD, Public Health, Epidemiology, and Radiology & Nuclear Medicine
- Published
- 2018
4. Edoxaban versus warfarin in patients with atrial fibrillation
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Robert P. Giugliano, Christian T. Ruff, Eugene Braunwald, Sabina A. Murphy, Stephen D. Wiviott, Jonathan L. Halperin, Albert L. Waldo, Michael D. Ezekowitz, Jeffrey I. Weitz, Jind?ich ?pinar, Witold Ruzyllo, Mikhail Ruda, Yukihiro Koretsune, Joshua Betcher, Minggao Shi, Laura T. Grip, Shirali P. Patel, Indravadan Patel, James J. Hanyok, Michele Mercuri, Elliott M. Antman, Braunwald E, Antman EM, Giugliano RP, Ruff CT, Morin SE, Hoffman EB, Murphy SA, Deenadayalu N, Grip L, Mercuri M, Lanz H, Patel I, Curt V, Duggal A, Hanyok J, Davé J, Morgan D, Choi Y, Shi M, Jin J, Xie J, Crerand W, Kappelhof J, Maxwell W, Skinner M, Patel S, Betcher J, Selicato G, Otto C. Jr, Reissner C, Smith K, Ostroske J, Ron A, Giugliano R, Connolly S, Camm J, Ezekowitz M, Halperin J, Waldo A, Paolasso E, Aylward P, Heidbuchel H, Nicolau JC, Goudev A, Roy D, Weitz J, Corbalán R, Yang Y, Botero R, Bergovec M, Ŝpinar J, Grande P, Hassager C, Voitk J, Huikuri H, Nieminen M, Blanc JJ, LeHeuzey JY, Mitrovic V, Alexopoulos D, Sotomora G, Kiss R, SomaRaju B, Lewis B, Merlini P, Metra M, Koretsune Y, Yamashita T, García Castillo A, Ophuis T, White H, Atar D, Horna M, Babilonia N, Ruzyllo W, Morais J, Dorobantu M, Ruda M, Ostojic M, Duris T, Dalby A, Chung N, Zamorano JL, Juul Möller S, Moccetti T, Chen SA, Sritara P, Oto A, Parkhomenko A, Senior R, Verheugt F, Skene A, Anderson J, Bauer K, Easton JD, Goto S, Wiviott S, Lowe C, Awtry E, Berger CJ, Croce K, Desai A, Gelfand E, Goessling W, Greenberger NJ, Ho C, Leeman DE, Link MS, Norden AD, Pande A, Rost N, Ruberg F, Silverman S, Singhal A, Vita JA, Vogelmann O, Gonzalez C, Ahuad Guerrero R, Rodriguez M, Albisu J, Rosales E, Allall O, Reguero M, Alvarez C, Garcia M, Ameriso S, Ameriso P, Amuchastegui M, Caceres M, Beloscar J, Petrucci J, Berli M, Budassi N, Valle M, Bustamante Labarta G, Saravia M, Caccavo A, Fracaro V, Cartasegna L, Novas V, Caruso O, Zarandon RS, Colombo H, Morandini M, Cuello J, Rosell M, Cuneo C, Bocanera M, D'Amico A, Cendali G, Dran R, Moreno V, Estol C, Davolos M, Facello A, Facello M, Falu E, Iriarte M, Femenia F, Arrieta M, Fuselli J, Zanotti A, Gant Lopez J, Meiller F, Garcia Duran R, Perlo D, Garrido M, Ceirano C, Giacomi G, Eden M, Giannaula R, Huerta M, Goicoechea R, von Wulffen M, Hominal M, Bianchini M, Jure H, Jure D, Kevorkian R, Monaco F, Lanternier G, Belcuore M, Liniado G, Iglesias M, Litvak B, Nigro A, Llanos J, Vignau S, Lorente C, Shatsky K, Lotti J, Raimondi G, Mackinnon I, Carne M, Manuale O, Calderon M, Marino J, Funes I, Muntaner J, Gandur H, Nul D, Verdini E, Piskorz D, Tommasi A, Povedano G, Casares E, Pozzer D, Fernandez E, Prado A, Venturini C, Ramos H, Navarrete S, Alvarez M, Sanchez A, Bowen L, Sanjurjo M, Codutti O, Saravia Toledo S, Formoso I, Schmidberg J, Goloboulicz A, Schygiel P, Buzzetti C, Severino P, Morara P, Sosa Liprandi M, Teves M, Vico M, Morell Y, Anderson C, Paraskevaidis T, Arstall M, Hoffmann B, Colquhoun D, Price Smith S, Crimmins D, Slattery A, Dart A, Kay S, Davis S, Silver G, Flecknoe Brown S, Roberts J, Gates P, Jones S, Lehman R, Morrison H, McKeirnan M, Li J, Paul V, Batta C, Purnell P, Perrett L, Szto G, O'Shea V, Capiau L, Banaeian F, De Bleecker J, de Koning K, De Tollenaere M, De Bruyne L, Desfontaines P, Tincani G, Meeusen K, Herzet J, Malmendier D, Mairesse G, Raepers M, Parqué J, Clinckemaille N, Scavée C, Huyberechts D, Stockman D, Jacobs C, Vandekerckhove Y, Derycker K, Vanwelden J, van Welden J, Vervoort G, Mestdagh I, Vrolix M, Beerts C, Wollaert B, Denie D, Amato Vincenzo de Paola A, Coutinho E, Andrade Lotufo P, de Melo RF, Atie J, Motta C, Augusto Alves da Costa F, Ferraz RF, Bertolim Precoma D, Sehnem E, Botelho R, Cunha S, Brondani R, Fleck N, Chaves Junior H, Silva J, Costantini C, Barroso D, De Patta M, Pereira V, Duda N, Laimer R, Dutra O, Morgado S, Faustino Saporito W, Seroqui M, Ferreira L, Araújo E, Finimundi H, Daitz C, Gagliardi R, Pereira G, Gomes M, Gomes A, Guimarães A, Ninho L, Jaeger C, Pereira L, Jorge J, Cury C, Kaiser S, Almeida A, Kalil C, Radaelli G, Kunz Sebba Barroso de Souza W, Morales K, Leaes P, Luiz RO, Pimenta Almeida J, Gozalo A, Reis G, Avellar K, Reis Katz Weiand L, Leipelt J, Rocha J, Barros R, Rodrigues L, Rocha MR, Rodrigues A, Rodrigues D, Rossi dos Santos F, Pagnan LG, Sampaio R, do Val R, Saraiva J, Vicente C, Simoes M, Carraro A, Sobral Filho D, Lustosa E, Villas Boas F, Almeida M, Zimmermann S, Zimmermann EB, Chompalova B, Parishev G, Denchev S, Milcheva N, Donova T, Gergova V, Georgiev B, Kostova E, Kinova E, Hergeldjieva V, Kamenova P, Manolova A, Vasilev I, Mihov A, Miteva B, Mincheva V, Stoyanovski V, Nikolov F, Vasilev D, Pencheva G, Kostov K, Petranov S, Milusheva T, Popov A, Staneva A, Momchilova Lozeva D, Todorov G, Nyagina M, Tumbev H, Tumbeva D, Tzekova M, Kitova M, Manoylov E, Archibald J, Antle S, Bhargava R, Stafford C, Bose S, Hundseth M, Cha J, Otis J, Chehayeb R, Lepage C, Chilvers M, Vansickle L, Cleveland D, Valley S, Constance C, Gauthier M, Costi P, Masson C, Coutu B, Denis I, du Preez M, Kubanska A, Dufresne M, Krider J, Eikelboom J, Zondag M, Fortin C, Viau C, Green M, Houbraken D, Hatheway R, Mabee J, Heath J, Scott L, Ho K, Ho V, Hoag G, Standring R, Huynh T, Perkins L, Kouz S, Roy M, Labonte R, Dewar C, Lainesse A, St Germain L, Lam S, Lam H, Lichtenstein T, Roberts P, Luton R, Douglas S, Ma P, Seib M, MacCallum C, Matthews J, Malette P, Vaillancourt T, Maranda C, Studenikow E, Mawji A, Morely A, Morrison D, Roth M, Mucha M, Najarali A, Lamoureux U, Nicholson R, O'Hara G, Banville P, O'Mahony W, Bolton R, Parkash R, Carroll L, Pesant Y, Sardin V, Polasek P, Turri L, Qureshi A, Nethercott C, Ricci J, Bozek B, Rupka D, Marchand C, Shu D, Silverio G, St Hilaire R, Morissette A, Sussman J, Kailey P, Syan G, Bobbie C, Talajic M, David D, Talbot P, Tremblay M, Teitelbaum I, Teitelbaum J, Velthuysen G, Giesbrecht L, Wahby R, Morley A, Wharton S, Caterini T, Woodford T, Balboa W, Matus LR, Bugueño C, Mondaca PM, Cobos J, Obreque C, Corbalan R, Parada A, Florenzano F, Diaz PA, Lopetegui M, Rebolledo C, Manriquez L, Silva LM, Martinez D, Llamas RR, Opazo M, Pérez MC, Pincetti C, Carrasco GT, Potthoff S, Staub JZ, Campisto Y, Stockins B, Lara CL, Yovaniniz P, Azua MG, Bai F, Xu GL, Chen JZ, Xie XD, Chen XP, Zhang X, Dong YG, Feng C, Fu GS, Zhang P, Hong K, You ZG, Hong L, Qiu Y, Jiang XJ, Qu Z, Li L, Liu H, Li TF, Kong YQ, Li WM, Liu B, Li ZQ, Liu Y, Liao DN, Gu XJ, Liu L, Lu ZH, Ma SM, Yang ZY, Wang DM, Qi SY, Wang GP, Shi XJ, Wei M, Huang D, Wu SL, Li YE, Xu JH, Gu JY, Xu YM, Liang YZ, Yang K, Li AY, Yang YJ, Zheng X, Zheng Y, Gao M, Yin YH, Xu YP, Yu B, Li LL, Yuan ZY, Qiang H, Zhang HQ, Lin YN, Zhang Z, Kang H, Zhao RP, Han RJ, Zhao XL, Wang JQ, Zheng ZQ, Li BG, Zhou SX, Zhang YL, Accini J, Accini M, Cano N, Pineda LL, Delgado Restrepo J, Arroyave C, Fernández Ruiz R, Diaz IA, Hernandez H, Delgado P, Jaramillo Muñoz C, Builes A, Manzur F, Rodriguez ER, Moncada Corredor M, Giraldo DL, Orozco Linares L, Fonseca J, Quintero A, Gonzales C, Sanchez Vallejo G, Mejia IP, Bagatin J, Carevic V, Car S, Jeric M, Ciglenecki N, Tusek S, Ferri Certic J, Romic I, Francetic I, Ausperger KM, Jelic V, Jurinjak SJ, Knezevic A, Buksa B, Samardzic P, Lukenda KC, Steiner R, Kirner D, Sutalo K, Bakliza Z, Vrazic H, Lucijanic T, Bar M, Brodova P, Berka L, Kunkelova V, Brtko M, Burianova H, Cermak O, Elbl L, Ferkl R, Florian J, Francek L, Golan L, Gregor P, Honkova M, Hubac J, Jandik J, Jarkovsky P, Jelinek Z, Jerabek O, Jirmar R, Kobza R, Kochrt M, Kostkova G, Kosek Z, Kovar P, Kuchar R, Kvasnicka J, Ludka O, Machova V, Krocova E, Melichar M, Nechanicky R, Olsr J, Peterka K, 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Pazier P, Riofrio K, Braun D, Robinson J, Cherrico M, Roehll W, Hollihan P, Rosado, Barnhorst M, Rosado J, Bamhorst M, Rosen R, Martin C, Ross S, Freeman R, Ruoff G, Nelson T, Sacco J, Ball E, Samal A, Schomburg J, Sandberg J, Lafave J, Savin V, Clifton R, Schaefer S, Fekete A, Schneider R, Schneider W, Schulman D, Mercer S, Seals A, Ullig T, Holt A, Seide H, Mather N, Shah G, Witt P, Shalaby A, Seese M, Shanes J, Fleets J, Shaoulian E, Hren A, Sheikh K, Hengerer T, Shih H, Browning J, Shoukfeh M, Stephenson L, Siler T, Champagne M, Simpson P, Meyer R, Singh N, Turner K, Singh V, Nelson M, Skierka R, Hughes B, Keene R, Smith R, Hodnett P, Spangenthal S, Thomason L, Sperling M, Vasquez E, Spivack E, McCartney P, Staniloae C, Liu M, Steljes A, Cox C, Struble R, Vittitow T, Suresh D, Frost J, Swerchowsky V, Freemyer D, Szulawski I, Herwehe S, Tahirkheli N, Springer K, Takata T, Bruton T, Talano J, Leo L, Tami L, Corchado D, Tatarko M, Swauger M, Tawney K, Dastoli K, Teague S, Young K, Tee H, Mitchell T, Teixeira J, Southam D, Torres M, Tucker P, Salas L, Updegrove J, Hanna K, Val Mejias J, Harrelson KG, Vemireddy D, Cardoza T, Verma S, Parsons T, Vicari R, Warren K, Vijay N, Washam M, Vossler M, Kilcup S, Walsh R, Renaud K, Ward S, Locklear T, Waxman F, Sanchez G, Weiss R, St Laurent B, Westcott J, Williams D, Gibson C, Williams R, Dowling C, Willis J, VonGerichten S, Wood K, Capasso Gulve E, Worley S, Pointer S, Yarows S, Sheehan T, Yasin M, Yi J, Dongas B, Yousuf K, Zakhary B, Curtis S, Zeig S, Mason T, Zellner C, Harden M, Roper E, Waseem M, Grammer M., PERRONE FILARDI, PASQUALE, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai [New York] (MSSM), University Hospitals Case Medical Center (CLEVELAND - UHCMC), University Hospitals Case Medical Center, Jefferson Medical College (JMC), Thomas Jefferson University Hospitals, Thrombosis and Atherosclerosis Research Institute (TARI), McMaster University [Hamilton, Ontario], University Hospital Brno, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Cardiology Research Center (MOSCOU - CRC), Cardiology Research Center, National Hopital Organization (OSAKA - NHO), Osaka National Hospital, Université de Brest (UBO), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Graduate School, Endocrinology, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Nursing, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, Giugliano, Rp, Ruff, Ct, Braunwald, E, Murphy, Sa, Wiviott, Sd, Halperin, Jl, Waldo, Al, Ezekowitz, Md, Weitz, Ji, Špinar, J, Ruzyllo, W, Ruda, M, Koretsune, Y, Betcher, J, Shi, M, Grip, Lt, Patel, Sp, Patel, I, Hanyok, Jj, Mercuri, M, Antman, Em, Comi, Giancarlo, ENGAGE AF TIMI 48, Investigators, Robert P., Giugliano, Christian T., Ruff, Eugene, Braunwald, Sabina A., 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Grammer, M.
- Subjects
Male ,Pyridines ,[SDV]Life Sciences [q-bio] ,Embolism ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Atrial Fibrillation ,MESH: Double-Blind Method ,030212 general & internal medicine ,MESH: Warfarin ,Stroke ,MESH: Aged ,MESH: Middle Aged ,Cardiovascular diseases [NCEBP 14] ,Hazard ratio ,General Medicine ,MESH: Follow-Up Studies ,Middle Aged ,3. Good health ,MESH: Atrial Fibrillation ,Cardiovascular Diseases ,Anesthesia ,Cardiology ,Female ,Adult ,Aged ,Anticoagulants ,Double-Blind Method ,Follow-Up Studies ,Hemorrhage ,Humans ,Thiazoles ,Warfarin ,MESH: Hemorrhage ,Andexanet alfa ,medicine.drug ,medicine.medical_specialty ,MESH: Enoxaparin ,MESH: Anticoagulants ,MESH: Stroke ,Dabigatran ,03 medical and health sciences ,Internal medicine ,medicine ,MESH: Kaplan-Meier Estimate ,Rivaroxaban ,MESH: Humans ,business.industry ,MESH: Cardiovascular Diseases ,MESH: Adult ,medicine.disease ,Confidence interval ,MESH: Male ,chemistry ,business ,MESH: Female ,MESH: Embolism - Abstract
Contains fulltext : 125374.pdf (Publisher’s version ) (Open Access) BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P
- Published
- 2013
5. Impact of Spontaneous Extracranial Bleeding Events on Health State Utility in Patients with Atrial Fibrillation: Results from the ENGAGE AF‐TIMI 48 Trial
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Senior, R., Paul, J., McKnight, T., Formoso, I., Saravia Toledo, S., Codutti, O., Sanjurjo, M., Bowen, L., Sanchez, A., Alvarez, M., Rodriguez, M., Navarrete, S., Ramos, H., Venturini, C., Prado, A., Fernandez, E., Pozzer, D., Casares, E., Povedano, G., Tommasi, A., Piskorz, D., Verdini, E., Nul, D., Gandur, H., Muntaner, J., Funes, I., Marino, J., Calderon, M., Manuale, O., Carne, M., Mackinnon, I., Raimondi, G., Lotti, J., Shatsky, K., Rodkey, K., Lorente, C., Vignau, S., Llanos, J., Nigro, A., Litvak, B., Iglesias, M., Liniado, G., Belcuore, M., Lanternier, G., Monaco, F., Kevorkian, R., Jure, D., Jure, H., Bianchini, M., Avery, D., Hominal, M., von Wulffen, M., McKenzie, M., Miranda, J., Wright, L., Pye, M., Flint, L., Newby, D., Andrews, A., Goicoechea, R., Huerta, M., Giannaula, R., Eden, M., Giacomi, G., Ceirano, C., Garrido, M., Perlo, D., Garcia Duran, R., Meiller, F., Gant Lopez, J., Zanotti, A., Fuselli, J., Arrieta, M., Femenia, F., Falu, E., Facello, M., Facello, A., Murdoch, D., Helliwell, L., More, R., Isted, C., Maxwell, T., Jones, D., Marazzi, P., McGhee, C., MacLeod, M., Ebano, P., MacCallum, P., Davolos, M., Estol, C., Moreno, V., Dran, R., Cendali, G., D'Amico, A., Bocanera, M., Cuneo, C., Rosell, M., Cuello, J., Morandini, M., Colombo, H., Brown, R., Saa Zarandon, R., Caruso, O., Novas, V., Cartasegna, L., Fracaro, V., Caccavo, A., Saravia, M., Bustamante Labarta, G., Valle, M., Budassi, N., Lip, G., Finlayson, M., Linker, N., McGuire, K., Atkinson, C., Lindsay, S., Ramasamy, V., Lie, F., Dickinson, D., Douglas, H., D'Costa, D., Wilmott, R., Cohen, A., Duff, J., Choy, A., Davies, D., Chapman, O., Dougal, K., Camm, J., Price, R., Blagden, M., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Rabadi-Marar, D., Dunn, S., Beeton, I., Smith, S., Aggarwal, R., Marar, I., Hernandez, S., Berli, M., Petrucci, J., Beloscar, J., Caceres, M., Amuchastegui, M., Ameriso, P., Ameriso, S., Garcia, M., Alvarez, C., Reguero, M., Allall, O., Rosales, E., Albisu, J., Ahuad Guerrero, R., Gonzalez, C., Vogelmann, O., Magnuson, Elizabeth A., Cohen, David J., Giugliano, Robert P., Mandviwala, M., Casas, R., Makam, S., Lisiecki, B., Mainigi, S., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Davids, M., Lone, B., Shah, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Simmons, T., Lang, J., Ferguson, D., Landau, C., Coyle, G. 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D., Herrod, J., Batchell, K., Hermany, P., Harkins, V., Henry, S., Millard, D., Henderson, D., Dandekar, U., Heiman, M., Krater, C., Hearne, S., Bobade, M., Harris, J., Cavanna, L., Han, M., Bentivenga, L., Hamroff, G., Morelli, L., Hack, T., McLean, R., Gvora, T., Felsman, D., Guthrie, R., Foster, B., Guerrero, Guerrero, Fisher, M., Guarnieri, T., Gabela, W., Guarino, J., Mabe, K., Grove, D., Davis, A., Grossman, C., Goodman, V., Griffin, J., Aull, L., Griffin, S., Bonora, M., Graham, S., Rafala, E., Gowda, S., Goldstein, M., Latteri, J., Goldscher, D., Ewing, B., Gogia, H., Keane-Richmond, P., Gillespie, E., Hinchion, N., Gerber, J., Valentine, H., George, F., Garb, J., Jones, J., Gaffney, M., Smith, K., Friedlander, I., Morales, C., French, W., Gentry, P., Franco, M., Thrope, C., Frais, M., Solis, A., Forman, S., Slayton, C., Flores, E., Donahue, S., Fishbein, G., Drew, B., Fischell, T., Lim, G., Finkelstein, S., Shriver, D., Finkel, M., Calvo, M., Fialkow, J., Prior, J., Felten, W., Tang, N., Feldman, J., Tameron, A., Feld, L., Watkins, D., Fahmy, R., DeSalle, D., Everhart, B., Shipp, A., Ettinger, N., O'Brien, J., Johnson, C., Erenrich, N., Cristaldi, J., Ellis, J., Quick, R., Eldadah, Z., Dunn, K., Eade, J., Cullen, T., D'Souza, A., Habibi, S., Drozdiak, R., Olson, A., Dotani, I., Rodriguez, L., Donovan, D., Tisdale, L., DiGiovanna, M., Ucik, S., Dhar, S., Briscoe, C., Devenport, S., Waters, L., Desire, A., Steward, A., Desai, A., Carey, J., DeGarmo, R., Warmack, D., Dean, J., Debes, C., De Lemos, J., Ebreo, N., Davuluri, A., Dave, B., Dave, K., Wulf, A., Datta, S., Leka, G., Daniels, S., Morgan, T., Dang, N., Sarpola, N., Curtis, B., Nelson, L., Cowan, L., Masson, E., Cottiero, R., Mullinax, K., Cossu, S., Svadbik, L., Corbett, B., Martinez, E., Concha, M., Cole, J., Salpas, S., Colan, D., Bossaers, J., Cohen, R., Dutka, C., McClelland, M., Clay, A., Clapp, T., Bagby, J., Ciaramita, J., Sawaya, K., Chaturvedi, S., Tamayo, M., Charlat, M., Hatfield, G., 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L., Fedotov, S., Malynovsky, Y., Gorna, O., Lizogub, V., Kyyak, Y., Kupnovytska, I., Stets, R., Kraydashenko, O., Usan, N., Kraiz, I., Kaplan, P., Koval', O., Ohirko, O., Koval, V., Dvoieglazova, M., Kotseruba, V., Petyunina, O., Kopytsya, M., Vasylets, V., Kolomyyits, S., Gerasimenko, N., Kaydashev, I., Blihar, O., Karpenko, Y., Nevolina, I., Karpenko, O., Samburg, Y., Godlevska, O., Husyev, V., Horbach, L., Dzublik, Y., Gavrysyuk, V., Sorokivskyy, M., Faynyk, A., Vasilyeva, L., Dzyak, G., Kulynych, R., Dotsenko, S., Lebedynskaya, M., Bereznyakov, I., Vlasyuk, Z., Bazylevych, A., Azhdari, M., Batushkin, V., Zoghi, M., Yigit, Z., Yigit, F., Tandogan, I., Turgut, O., Oto, A., Kanadasi, M., Kabul, K., Ermis, C., Erdogan, D., Ceyhan, C., Cayli, M., Calik, A., Cakmak, N., Bayata, S., Ata, N., Demir, H., Akilli, H., Acikel, M., Puripun, E., Vorasettakarnkij, Y., Mekara, W., Sukonthasarn, A., Panpunuan, P., Sritara, P., Sripracha, A., Piyayotai, D., Bamrungpong, P., Laothavorn, P., Sriprasert, S., Kiatchoosakun, S., Sinthusopa, W., Kaewsuwanna, P., Pornchaiyasit, K., Jirasirirojanakorn, K., Kuo, J. Y., Yeh, H. I., Tsai, W. C., Lee, S. C., Ueng, K. C., Pan, Y. F., Tseng, W. K., Chiu, C. Z., Shyu, K. G., Lin, K. H., Pai, P. Y., Lee, J. T., Lin, T. H., Lai, W. T., Wang, C. L., Kuo, C. T., Chen, Y. F., Huang, J. L., Chen, Y. P., Hsia, C. H., Yeh, T. C., Chiou, C. W., Wu, Y. W., Chiang, F. T., Yu, W. C., Chiang, C. E., Wu, W. S., Cheng, C. C., Slater, I. Petrova, Moccetti, T., Broberg, M., Thulin, J., Gunnarsson, A., Stenberg, A., Sundholm, C., Ronn, F., Johansson, M., Rautio, A., Moodh, J., Randers, F., Eriksson, G., Malmqvist, L., Edlund, M., Kozak, P., Hakansson, E., Koskinen, P., Jernhed, H., Juul-Moller, S., Winberg, L., Herlitz, J., Karlsson, L., Engdahl, J., Ostberg, S., Dettmann, S., Bengtsson, A. Stener, Carlsson, T., Persson, L., Blomstrom, P., Andersson, R., Blom, K. Berndtsson, Akerberg, A., Appelros, P., Astier, L., Villuendas, R., Dachs Delgado, M., Terns, M., Fernandez Alvarez, R., Fernandez, M., Arias, J., Diaz-Pintado, M., Merino, J., Blanco Abril, S., Manzano, L., Barquero, R., Lopez Garcia-Aranda, V., Delgado, A., Hernandez Madrid, A., Moure, M., Gonzalez Juanatey, J., Perez Guevara, M., Diez Tejedor, E., Asensio, A., De Arce Borda, A., Calvo, G., Calvo, C., Cabero, P., Bruguera Cortada, J., Puertas, I., Blanco Coronado, J., Manzanal Rey, A., Arcocha Torres, M., Kim, J. Y., Rim, S. J., Na, J. O., Rha, S. W., Kwak, J. J., Namgung, J., Shin, D. G., Lee, S. H., Joung, B. Y., Lee, M. H., Chun, M. Y., Kim, Y. J., Seo, J. B., Kim, S. H., Park, S. J., Kim, J. S., Park, J. H., Kim, J. H., Park, M. S., Kim, J. T., Cha, M. J., Kim, H. S., Seo, J. S., Kim, D. S., Jin, E. S., Kim, C. J., Choi, K. J., Kang, D. H., Lee, J. M., Jeon, H. K., Jung, J. W., Hyon, M. S., Lee, H. W., Hong, T. J., Lee, K. H., Han, S. H., Oh, Y. S., Chung, W. S., Hong, K. S., Choi, H. H., Ryu, D. R., Cho, B. R., Kim, D. H., Cha, J. K., Han, M. G., Bae, H. J., Wessels, L., Venter, T., Le Roux, M., Van Zyl, L., Goosen, Y., Van Der Merwe, N., Johnston, H., Soma, P., Munnik, M., Snyders, F., Duki, Y., Naidoo, D., Taljaard, J., Mitha, I., Kelfkens, Y., Wilson, L., Gani, M., Nunkoo, T., Essop, M., Mostert, M., Engelbrecht, J., Botha, L., Ellis, G., Allman, J., Dalby, A., Poynton, M., Basson, M., Erasmus, L., Badenhorst, J., Bollova, D., Zareczky, P., Kokles, M., Zachar, A., Kmec, J., Slanina, M., Morsky, J., Ruffini, L., Fedacko, J., Pella, D., Mazur, J., Reptova, A., Kasperova, V., Hofmanova, J., Hranai, M., Hatala, R., Hatalova, K., Dzupinova, M., Dzupina, A., Vankova, L., Duris, T., Dulka, T., Dulkova, K., Kosmalova, V., Dukat, A., Banikova, A., Ambrovic, I., Ambrovicova, V., Tesic, M., Golshmid, M., Ruda, M., Topolnitchi, O., Castro, C., Ostojic, M., Tesic, B. 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L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Han, R. J., Zhao, R. P., Kang, H., Zhang, Z., Lin, Y. N., Zhang, H. Q., Qiang, H., Yuan, Z. Y., Li, L. L., Yu, B., Xu, Y. P., Yin, Y. H., Gao, M., Zheng, Y., Zheng, X., Yang, Y. J., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Liao, D. N., Liu, Y., Li, Z. Q., Liu, B., Li, W. M., Kong, Y. Q., Li, T. F., Liu, H., Li, L., Qu, Z., Jiang, X. J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. L., Bai, F., Grandon Azua, M., Yovaniniz, P., Lara Lara, C., Stockins, B., Campisto, Y., Zapata Staub, J., Potthoff, S., Torres Carrasco, G., Pincetti, C., Carmona Perez, M., Opazo, M., Romero Llamas, R., Martinez, D., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Lopetegui, M., Arratia Diaz, P., Florenzano, F., Parada, A., Corbalan, R., Obreque, C., Cobos, J., Mondaca Mondaca, P., Bugueno, C., Retamal Matus, L., Balboa, W., Mabee, J., Woodford, T., Caterini, T., Wharton, S., Morley, A., Wahby, R., Giesbrecht, L., Velthuysen, G., Teitelbaum, J., Teitelbaum, I., Tremblay, M., Talbot, P., David, D., Talajic, M., Bobbie, C., Syan, G., Kailey, P., Sussman, J., St-Hilaire, R., Silverio, G., Shu, D., Marchand, C., Rupka, D., Bozek, B., Ricci, J., Nethercott, C., Qureshi, A., Mercado, A., Cervellione, K., Mendelson, R., Turri, L., Polasek, P., Sardin, V., Pesant, Y., Carroll, L., Parkash, R., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Najarali, A., Krider, J., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Malette, P., Matthews, J., MacCallum, C., Seib, M., Ma, P., Douglas, S., Luton, R., Roberts, P., Lichtenstein, T., Lam, H., Lam, S., St-Germain, L., Lainesse, A., Dewar, C., Labonte, R., Roy, M., Kouz, S., Perkins, L., Huynh, T., Standring, R., Hoag, G., Ho, V., Ho, K., Scott, L., Heath, J., Hatheway, R., Houbraken, D., Viau, C., Fortin, C., Zondag, M., Eikelboom, J., Dufresne, M., Kubanska, A., du Preez, M., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Chehayeb, R., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Wall, J., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., Wollaert, B., Beerts, C., Vrolix, M., Mestdagh, I., Vervoort, G., van Welden, J., Vanwelden, J., Derycker, K., Vandekerckhove, Y., Jacobs, C., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., Stockman, D., Huyberechts, D., Scavee, C., Clinckemaille, N., Parque, J., Raepers, M., Mairesse, G., Malmendier, D., Herzet, J., Meeusen, K., Heidbuchel, H., Tincani, G., Desfontaines, P., De Bruyne, L., De Tollenaere, M., de Koning, K., De Bleecker, J., Banaeian, F., Capiau, L., O'Shea, V., Szto, G., Perrett, L., Purnell, P., Batta, C., Paul, V., Li, J., McKeirnan, M., Morrison, H., Wright, J., Wright, A., Chung, A., Watkin, R., Gilchrist, M., Venkataraman, A., Lehman, R., Jones, S., Gates, P., Flecknoe-Brown, S., Silver, G., Davis, S., Kay, S., Dart, A., Slattery, A., Crimmins, D., Price-Smith, S., Colquhoun, D., Hoffmann, B., Arstall, M., Paraskevaidis, T., Anderson, C., Morell, Y., Vico, M., Teves, M., Sosa Liprandi, M., Morara, P., Severino, P., Buzzetti, C., Schygiel, P., Walker, M., Turner, W., Bridge, C., Storey, R., Goloboulicz, A., Schmidberg, J., Kennard, S., Sopher, M., McLaurin, B., Young, G., Kwong, Winghan J., Antman, Elliott M., Ruff, Christian T., Wang, J. H., Iriarte, M., Morissette, A., Wang, Kaijun, Li, Haiyan, and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Complications ,Time Factors ,Pyridines ,Health Status ,Embolism ,Hemorrhage ,Arrhythmias ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,In patient ,Prospective Studies ,030212 general & internal medicine ,anticoagulation ,Blood Coagulation ,Original Research ,Aged ,Aged, 80 and over ,Quality and Outcomes ,business.industry ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,bleeding ,medicine.disease ,Stroke ,Thiazoles ,Treatment Outcome ,quality of life ,utility ,Physical therapy ,Cardiology ,Female ,Warfarin ,Gastrointestinal Hemorrhage ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,Health Services and Outcomes Research ,Factor Xa Inhibitors - Abstract
Background The impact of different types of extracranial bleeding events on health‐related quality of life and health‐state utility among patients with atrial fibrillation is not well understood. Methods and Results The ENGAGE AF ‐ TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48) Trial compared edoxaban with warfarin with respect to the prevention of stroke or systemic embolism in atrial fibrillation. Data from the EuroQol‐5D ( EQ ‐5D‐3L) questionnaire, prospectively collected at 3‐month intervals for up to 48 months, were used to estimate the impact of different categories of bleeding events on health‐state utility over 12 months following the event. Longitudinal mixed‐effect models revealed that major gastrointestinal bleeds and major nongastrointestinal bleeds were associated with significant immediate decreases in utility scores (−0.029 [−0.044 to −0.014; P P =0.001], respectively). These effects decreased in magnitude over time, and were no longer significant for major nongastrointestinal bleeds at 9 months, but remained borderline significant for major gastrointestinal bleeds at 12 months. Clinically relevant nonmajor and minor bleeds were associated with smaller but measurable immediate impacts on utility (−0.010 [−0.016 to −0.005] and −0.016 [−0.024 to −0.008]; P Conclusions All categories of bleeding events were associated with negative impacts on health‐state utility in patients with atrial fibrillation. Major bleeds were associated with relatively large immediate decreases in utility scores that gradually diminished over 12 months; clinically relevant nonmajor and minor bleeds were associated with smaller immediate decreases in utility that persisted over 12 months. Clinical Trial Registration URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT00781391.
- Published
- 2017
6. Verhaltensauffälligkeiten mit 9 Jahren zur Vorhersage von Schulproblemen im Alter von 11 und 15 Jahren
- Author
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Ulrich Wahn, Fred Zepp, Hoffmann U, Christina Krause, Johannes Forster, Karl E. Bergmann, Renate L. Bergmann, Thomas Keil, Antje Schuster, C.P. Bauer, Susanne Lau, Reinhard Beyer, Cynthia Hohmann, and Linus Grabenhenrich
- Subjects
Gynecology ,Psychiatry and Mental health ,medicine.medical_specialty ,Behavior disorder ,business.industry ,Pediatrics, Perinatology and Child Health ,Developmental and Educational Psychology ,Medicine ,business - Abstract
Verhaltensauffälligkeiten im Kindesalter stellen einen Risikofaktor für psychische Auffälligkeiten und verminderte schulische Leistungsfähigkeit dar. Die Studie untersucht, ob eine geringere Funktionalität im Grundschulalter die Auftretenswahrscheinlichkeit von Schulproblemen in der Adoleszenz erhöht. Fragebogendaten der 9-, 11- und 15-Jahres Nachuntersuchungen der MAS-Geburtskohorte (N=1314 Baselineerhebung bei Geburt; 47.9 % Mädchen, 52.1 % Jungen) werden ausgewertet. Erhoben werden Funktionalität auf den Dimensionen Psychisches Wohlergehen, Körperlicher Status, Soziale Beziehungen und Alltagsfunktionsfähigkeit zu 9 Jahren sowie das Vorkommen von Schulproblemen mit 11 und 15 Jahren. Eine geringere Funktionalität im Alter von 9 Jahren geht mit einer erhöhten Auftretenswahrscheinlichkeit von Schulproblemen mit 11 (adjustierte Odds Ratio [aOR]=3.53, 95 %Konfidenzintervall [KI] 2.20 – 5.66) und 15 Jahren (aOR=3.22, 95 %KI 1.85 – 5.62) einher. Diese Effekte zeigen sich deutlicher für Jungen als für Mädchen. Bereits Grundschulkinder können Einschränkungen in ihrer Funktionalität zeigen, welche über Jahre stabil zu bleiben scheinen und mit Schulproblemen in der Adoleszenz einhergehen können.
- Published
- 2014
7. THE NEUTRALIZING ANTIBODY-RESPONSE AGAINST VESICULAR STOMATITIS-VIRUS
- Author
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ZINKERNAGEL, R, Bachmann, M, KALINKE, U, ROOST, H, HOFFMANN, U, BURKI, K, RULICKE, T, and HENGARTNER, H
- Published
- 2016
8. Stroke and Mortality Risk in Patients With Various Patterns of Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
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Jones, D., Gu, X. J., Liu, L., Grammer, M., Waseem, M., Roper, E., Harden, M., Zellner, C., Mason, T., Zeig, S., Curtis, S., Zakhary, B., Yousuf, K., Wharton, S., VonGerichten, S., Willis, J., Dowling, C., Williams, R., Gibson, C., Williams, D., Truva, C., Westcott, J., St Laurent, B., Weiss, R., Sanchez, G., Waxman, F., Locklear, T., Ward, S., Renaud, K., Walsh, R., Kilcup, S., Vossler, M., Washam, M., Vijay, N., Warren, K., Vicari, R., Parsons, T., Verma, S., Cardoza, T., Vemireddy, D., Harrelson, K. Gonzalez, Val-Mejias, J., Hanna, K., Updegrove, J., Salas, L., Tucker, P., Romero, N., Torres, M., Southam, D., Teixeira, J., Mitchell, T., Tee, H., Young, K., Teague, S., Dastoli, K., Tawney, K., Swauger, M., Tatarko, M., Corchado, D., Tami, L., Leo, L., Talano, J., Bruton, T., Takata, T., Springer, K., Tahirkheli, N., Herwehe, S., Szulawski, I., Freemyer, D., Swerchowsky, V., Frost, J., Suresh, D., Vittitow, T., Struble, R., Cox, C., Steljes, A., Liu, M., Staniloae, C., McCartney, P., Spivack, E., Vasquez, E., Sperling, M., Thomason, L., Spangenthal, S., Hodnett, P., Smith, R., Keene, R., Smith, S., Hughes, B., Skierka, R., Nelson, M., Singh, V., Turner, K., Singh, N., Meyer, R., Simpson, P., Champagne, M., Siler, T., Stephenson, L., Shoukfeh, M., Browning, J., Shih, H., Hengerer, T., Sheikh, K., Hren, A., Shaoulian, E., Fleets, J., Shanes, J., Seese, M., Shalaby, A., Witt, P., Shah, G., Mather, N., Seide, H., Holt, A., Ullig, T., Seals, A., Mercer, S., Schulman, D., Schneider, W., Schneider, R., Fekete, A., Schaefer, S., Clifton, R., Savin, V., Lafave, J., Sandberg, J., Schomburg, J., Samal, A., Ball, E., Sacco, J., Nelson, T., Ruoff, G., Freeman, R., Ross, S., Martin, C., Rosen, R., Barnhorst, M., Rosado, J., Hollihan, P., Roehll, W., Cherrico, M., Robinson, J., Braun, D., Riofrio, K., Roberts, J., Pazier, P., Richwine, R., Stanley, E., Renzi, M., Wroblewski, J., Redondo, V., Domingo, D., Rama, P., Hemmen, C., Quinn, J., Reed, C., Quinlan, E., Rafla, E., Quadrel, M., Ebert, J., Pugeda, J., Sham, L., Pudi, K., Lowe, K., Pribble, A., Neeper, L., Pratt, R., Cush, S., Poulathas, A., Kirk, D., Yovaniniz, P., Pezzella, S., Brown, F., Pettis, K., Morlando, F., Petruzziello, F., Chacon, L., Peters, P., Duncan, D., Pentz, W., Montayne, S., Pearlstein, R., Gorry, N., Pavon, H., Dennison, K., Patnam, S., Joseph, L., Oza, S., Gonzalez, M., Osborne, J., Garcia, L., Orchard, R., McCormick, J., Oppenheimer, K., Thakkar, N., Oberoi, M., Wilmot, M., Nielsen, R., Nomanee, S., Nguyen, T., Goza, J., Nallasivan, M., West, M., Naidu, J., Parker, A., Nadar, V., Oehmann, V., Murphy, A., Raziano, S., Mullen, P., Todd, S., Mowdy, M., Schuler, C., Mounsey, P., Parrott, N., Mouhaffel, A., Bowman, B., Morledge, J., Garner, S., Moran, J., Strugatsky, S., Mody, F., Gryczan, J., Miller, S., Sanchez, S., Miller, R., Sanders, D., Milas, J., Romero-Colon, J., Michlin, B., Cajulis, C., Mercado, A., Cervellione, K., Mendelson, R., Wall, J., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., McLaurin, B., Paul, J., McKnight, T., Rodkey, K., McKenzie, M., Miranda, J., McGuire, K., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Rabadi-Marar, D., Marar, I., Hernandez, S., Mandviwala, M., Casas, R., Makam, S., Lisiecki, B., Mainigi, S., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Davids, M., Lone, B., Shah, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Simmons, T., Lang, J., Ferguson, D., Landau, C., Coyle, G. 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- Subjects
Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,Pyridines ,medicine.medical_treatment ,Factor Xa Inhibitor ,Hemorrhage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Risk Factors ,Physiology (medical) ,Internal medicine ,Thromboembolism ,Atrial Fibrillation ,Medicine ,Humans ,atrial fibrillation ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Stroke ,Aged ,business.industry ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,thromboembolism ,bleeding ,medicine.disease ,mortality ,stroke ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,medicine.drug ,Factor Xa Inhibitors - Abstract
Background— Whether the pattern of atrial fibrillation (AF) modifies the risk/benefit of anticoagulation is controversial. In ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48), the factor Xa inhibitor edoxaban was noninferior to warfarin in preventing stroke or systemic embolic events and significantly reduced bleeding and cardiovascular mortality. However, detailed analyses by AF pattern have not been reported. Methods and Results— The 21 105 patients were categorized as having paroxysmal (P -adj =0.015) and permanent AF (1.95%/year; P -adj =0.004). Overall, all-cause mortality also was lower with paroxysmal (3.0%/year) compared with persistent (4.4%/year; P -adj P -adj Conclusions— In ENGAGE AF-TIMI 48 trial, patients with paroxysmal AF suffered fewer thromboembolic events and deaths compared with those with persistent and permanent AF. The efficacy and safety profile of edoxaban as compared with warfarin was consistent across the 3 patterns of AF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2016
9. Die German Infant Nutritional Intervention Study (GINI) zur präventiven Wirkung von Hydrolysatnahrungen bei Kindern mit Allergierisiko. Design und ausgewählte Ergebnisse
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C. P. Bauer, Joachim Heinrich, Sybille Koletzko, C. Beckmann, A. von Berg, E. Wichmann, Armin Grübl, Birgit Filipiak-Pittroff, Elke Link, Dietrich Berdel, Dietrich Reinhardt, Ulrich Kramer, and Hoffmann U
- Subjects
business.industry ,Rehabilitation ,Immunology and Allergy ,Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,business - Published
- 2012
10. GINIplus und LISAplus. Design und ausgewählte Ergebnisse zweier deutscher Geburtskohorten zum natürlichen Verlauf atopischer Erkrankungen sowie deren Determinanten
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C. P. Bauer, Hoffmann U, Sybille Koletzko, B. Schaaf, Markus Schnappinger, Joachim Heinrich, Ulrich Kramer, M. Borte, Irina Lehmann, Olf Herbarth, Dietrich Berdel, J. Ring, C. Beckmann, A. von Berg, Irene Brüske, C. Cramer, Armin Grübl, and Heidrun Behrendt
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business.industry ,Immunology and Allergy ,Medicine ,business - Published
- 2012
11. Limited clinical relevance of imaging techniques in the follow-up of patients with advanced chronic lymphocytic leukemia: results of a meta-analysis
- Author
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Eichhorst, Barbara F, Fischer, Kirsten, Fink, Anna Maria, Elter, Thomas, Wendtner, Clemens M, Goede, Valentin, Bergmann, Manuela, Stilgenbauer, Stephan, Hopfinger, Georg, Ritgen, Matthias, Bahlo, Jasmin, Busch, Raymonde, Hallek, Michael, Oduncu, F, Dreyling, M, Forstpointner, R, Schneller, F, Bogner, C, Peschel, C, Ringshausen, I, Götze, K, Goebeler, Me, Rückle, Lanz, Ritgen, M, Schawitzke, A, Heydrich, B, Kern, K, Böttcher, S, Irmer, S, Strack, U, Borries, V, Klima, Km, Scholz, C, Herold, M, Härtwig, K, Dürig, J, Dührsen, U, Müller Beissenhirtz, H, Noppeney, R, Schüttrumpf, S, Hohloch, K, Binder, C, Hasenkamp, J, Trümper, L, Bäsecke, J, Rieger, M, Witzens Harig, M, Friedrichs, B, Rieger, K, Uharek, L, Kubuschok, B, Murawski, N, Held, G, Zwick, C, Pfreundschuh, M, Fingerle Rowson, G, Reiser, M, Elter, T, Eichhorst, B, Pallasch, C, Hallek, M, Borchmann, P, Hacker, U, Schinkel, S, Wieker, K, Sökler, M, Wolf, Hh, Eucker, J, Staib, P, Schlegel, F, Kropff, M, Kahl, C, Hess, G, Beck, J, Wölfel, T, Bokemeyer, C, Schilling, G, Dierlamm, J, Schüler, F, Busemann, C, Dölken, G, Trendelenburg, Tk, Bühler, A, Stilgenbauer, S, Viardot, A, Greiner, J, Zenz, T, Gaidzik, V, Langer, C, Döhner, H, Werner, I, Dienst, A, Habersang, K, Härtel, N, Leitner, A, Kehrer, G, Middeke, H, Heinisch, K, Adorf, D, Ismer, B, Hering Schubert, C, Jäckle, J, Aulmann, C, Söllner, S, Majunke, P, Fuss, H, Käfer, G, Potenberg, J, Dietrich, G, Hartung, E, Pronath, A, Riedhammer, Fj, Zehrfeld, T, Prümmer, O, Gatter, J, Meier, A, Wattad, M, Heit, W, Sauer, I, Hilgers, K, Geissler, M, Bauer, J, Stein, W, Voigtmann, R, Natt, F, Nickelsen, M, Zeis, M, Schmitz, N, Lange, E, Stoltefuss, A, Schubert, J, Dürk, Ha, Kloke, O, Fauser, A, Roemer, E, Kraut, L, Musch, E, Kohl, S, Link, H, Kirsch, Jf, Schatz, M, Mezger, J, Kempf, B, Heil, G, Derigs, Hg, Roll, C, Kettner, E, Dübbers, Hw, Lutz, L, Hentrich, M, Hoffmann, U, Ibe, M, Falge, C, Schäfer Eckart, K, Rothmann, F, Raghavachar, A, Beckmann, K, Behringer, D, Stauder, H, Hempfling, C, Matzdorff, A, Hähling, D, Kaesberger, Kj, Mück, R, Waladkhani, Ar, Clemens, M, Kraft, J, Ehlert, T, N. N., Schloen, A, Sandritter, B, Scholz, Diekmann, C, Pflüger, Kh, Hausner, G, Fetscher, S, Aulitzky, W, Brugger, W, Frickhofen, N, Fuhr, Lange, C, Lambertz, H, Schulz, L, Schmier, M, Bentz, M, Tauchmann, Gm, Schmidt, M, Meiler, J, Sandmann, M, Kürschner, D, Maier Bay, B, Lindemann, W, Diers, J, Riemeier Sievers, C, Daun, M, Mergenthaler, Hg, Hiller, S, Schirmer, V, Kirchner, H, Langer, W, Günther, B, Gassmann, W, Franke, K, Burghardt, F, Abele, U, Celikel Becker, D, von Weikersthal LF, Brög, G, Hauch, U, Heinrich, B, Brudler, O, Häcker, B, Eckart, Mj, Bolouri, H, Göttler, B, Kindler, M, Zuchold, K, Strohbach, F, Plingen, Ml, Seibt Jung, H, Kirsch, A, Herrenberger, J, Doering, G, von Grünhagen, U, Franke, H, Weniger, J, Kerzel, W, Schmalfeld, M, Rohrberg, R, Hurtz, Hj, Gehbauer, G, Hahnfeld, S, Vehling Kaiser, U, Abenhardt, W, Bosse, D, Böning, L, Schmidt, B, Schick, Hd, Jacobs, G, Stauch, M, Hoffmann, R, Müller, S, Hahn, M, Freier, W, Dietzfelbinger, H, Rassmann, I, Söling, U, Siehl, S, Rudolph, R, Weinert, R, Sauer, A, Meyer, B, Eschenburg, H, Schadeck Gressel, C, Grabenhorst, U, Perker, M, Otremba, B, Reschke, D, Hinrichs, Hf, Zirpel, I, Höring, E, Respondek, M, Köppler, H, Heymanns, J, Weide, R, Hünermund, K, Thiel, C, Reiber, T, Spohn, C, Springer, G, Fiechtner, H, Hübner, A, Kurschel, E, Weiss, J, Schlag, R, Schäfer, E, Hartwich, G, Schmitz, S, Steinmetz, T, Kim, Ts, Lerchenmüller, C, Wehmeyer, J, Laubenstein, Hp, Rendenbach, B, Lebahn, H, Kröning, H, Uhle, R, Balló, H, Gaede, B, Zumbrink, S, Eckert, R, Kamp, T, Reimann, B, Burkhard, O, Mittermüller, J, Hansen, R, Hitz, H, Schliesser, G, Schmitt, Hr, Forstbauer, H, Grundeis, M, Schulze, M, Baldus, M, Lakner, V, Haen, M, Müller, C, Dörfel, S, Göhler, T, Welslau, M, Achtzehn, V, Culmann, H, Gerhardt, S, Ulshöfer, T, Koschuth, A, Schmidt, P, Müller, L, Schneider, M, Koniczek, K, Porowski, P, Glados, M, Knoblich, J, Ben Yehuda, D, Jäger, U, Gaiger, A, Schwarzmeier, J, Nösslinger, T, Smith, M, Patton, N, Gibbons, S, Bouabdallah, R, Gandhi, M, Marlton, P, Mills, T, Angelucci, E, Sorano, Gg, Casula, P, Berneman, Z, Kohser, P, Hudcova Burgetova, A, Machová, R, Papajik, T, Kubová, Z, Fineman, R, Mayer, J, Doubek, M, Brychtova, Y, Ciceri, F, Caligaris Cappio, F, Crocchiolo, R, Dauriac, C, Bernard, M, Escoffre Barbe, M, Lamy, T, Zikesova, E, Karban, J, Salkova, J, Trnený, M, Pytlik, R, Tiley, C, Forsyth, C, Vokurka, S, Koza, V, Van Hoof, A, Selleslag, D, Sebban, C, Baker, B, Belada, D, Jebavy, L, Smolej, L, Pavel, Z, Di Ianni, M, Castaigne, S, Del Poeta, G, Amadori, S, Catalano, J, Ganju, V, Hertzberg, M, Laurenti, L, Dalseg, Am, Bron, D, Morton, J, Durrant, S, Casado, Lf, Theunissen, K, Atias, D, Berkhan, L, Seymour, J, Wolf, M, Bosly, A, Osma Cordoba MM, Portois, C, Jaubert, J, Ferrant, A, Lambert, C, Maerevoet, E, Van den Neste, E, Gadeberg, O, Carney, B, Cannell, P, Eghbali, H, Legouffe, E, Bordessoule, D, Chaury, M, Moreau, S, Pierri, I, Gobbi, M, Berrebi, A, Lishner, M, Yerushazim, R, Yermiaku, T, Kosolov, V, Ambrosetti, Achille, Andreoli, Al, Huguet, F, Laurent, G, Orsucci, L, Forconi, F, Musuraca, G, Zinzani, Pl, Loscertales, J, Mcquillan, A, Cordingley, F, Leahy, M, Cazin, B, Taylor, Mulligan, S, Herbrecht, Cull, G, Seldon, M, Rowlings, P, Ludwig, H, Zojer, N, Solal Céligny, P, Pomponi, F, Savdkova, L, Kozák, T, Christiansen, I, Pérez, I, Campbell, P, Canales Albendea, M, De Paz, R, Arthur, C, Gisselbrecht, C., Eichhorst B.F., Fischer K., Fink A.M., Elter T., Wendtner C.M., Goede V., Bergmann M., Stilgenbauer S., Hopfinger G., Ritgen M., Bahlo J., Busch R., Hallek M., and Zinzani P.L.
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Male ,medicine.medical_specialty ,Cyclophosphamide ,Chronic lymphocytic leukemia ,Immunology ,Medizin ,Antineoplastic Combined Chemotherapy Protocols ,Blood Cell Count ,Disease Progression ,Disease-Free Survival ,Female ,Follow-Up Studies ,Humans ,Leukemia, Lymphocytic, Chronic, B-Cell ,Middle Aged ,Prognosis ,Recurrence ,Remission Induction ,Tomography, X-Ray Computed ,Physical examination ,Biochemistry ,Chemoimmunotherapy ,medicine ,Chronic ,Tomography ,Leukemia ,medicine.diagnostic_test ,business.industry ,B-Cell ,Cancer ,Cell Biology ,Hematology ,medicine.disease ,Lymphocytic ,imaging techniques ,X-Ray Computed ,Fludarabine ,Surgery ,chronic lymphocytic leukemia ,Radiology ,business ,Progressive disease ,medicine.drug - Abstract
The clinical value of imaging is well established for the follow-up of many lymphoid malignancies but not for chronic lymphocytic leukemia (CLL). A meta-analysis was performed with the dataset of 3 German CLL Study Group phase 3 trials (CLL4, CLL5, and CLL8) that included 1372 patients receiving first-line therapy for CLL. Response as well as progression during follow-up was reassessed according to the National Cancer Institute Working Group1996 criteria. A total of 481 events were counted as progressive disease during treatment or follow-up. Of these, 372 progressions (77%) were detected by clinical symptoms or blood counts. Computed tomography (CT) scans or ultrasound were relevant in 44 and 29 cases (9% and 6%), respectively. The decision for relapse treatment was determined by CT scan or ultrasound results in only 2 of 176 patients (1%). CT scan results had an impact on the prognosis of patients in complete remission only after the administration of conventional chemotherapy but not after chemoimmunotherapy. In conclusion, physical examination and blood count remain the methods of choice for staging and clinical follow-up of patients with CLL as recommended by the International Workshop on Chronic Lymphocytic Leukemia 2008 guidelines. These trials are registered at http://www.isrctn.org as ISRCTN 75653261 and ISRCTN 36294212 and at http://www.clinicaltrials.gov as NCT00281918.
- Published
- 2011
12. Is High-Frequency Flux Motion due to Respiration or to Vasomotion Activity?1
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A. Yanar, Franzeck Uk, A. Bollinger, and Hoffmann U
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business.industry ,Respiration ,Biophysics ,Medicine ,Vasomotion ,Flux motion ,business - Published
- 2015
13. Investigating a Model for Acute Ischemic Pain in Humans
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Abahji T, Kuhlencordt Pj, Kreth S, Irnich D, Lang Pm, Mussack T, Hoffmann U, Alexander Crispin, Freiberg Fj, and Thiel M
- Subjects
medicine.medical_specialty ,business.industry ,Arterial disease ,Inflammation ,Omics ,medicine.disease ,Ischemic pain ,Pathophysiology ,Surgery ,Peripheral ,medicine.anatomical_structure ,Tendinitis ,Internal medicine ,medicine ,Cardiology ,medicine.symptom ,Ankle ,business - Abstract
Background: The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies. We examined whether peripheral nerve damage and acute inflammation occur during short episodes of acute ischemia. Methods: Eleven patients with unilateral peripheral arterial disease (PAD) performed treadmill exercise until intolerable ischemic pain urged them to stop. Blood samples were taken before, immediately after treadmill exercise and after a period of recovery. S100B-serum was detected via Elecsys® S100B Immunoassay and IL-6 levels determined via COBAS® IL6 Elecsys 2010. Results: Treadmill exercise led to intolerable exercise-induced ischemic pain (Numeric Rating Scale) 9 ± 0.3 (0- 10, mean ± SEM)) in the PAD affected leg. Reduced ankle/brachial-index (ABI) (0.13 ± 0.05 mean ± SEM) with a mean ankle pressure of 26 ± 9 mmHg, pO2, pH and increased serum lactate indicated that severe ischemia occurred in the PAD affected leg. The inflammation marker IL-6 increased locally and systemically post exercise (n.s.). Conclusion: We present an effective method to examine acute ischemic pain in humans. By focusing on changes in metabolic parameters in the affected limb, this model could potentially help to evaluate and detect changes during acute ischemic pain and thus contribute to the understanding of the underlying pathophysiology.
- Published
- 2015
14. Die Oxytozin-Signalkaskade im Rahmen vorzeitiger Wehentätigkeit
- Author
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Friebe-Hoffmann U
- Subjects
medicine.medical_specialty ,Preterm labor ,Premature labor ,business.industry ,Decidua ,Myometrium ,Obstetrics and Gynecology ,Alpha (ethology) ,Paracrine signalling ,medicine.anatomical_structure ,Endocrinology ,Oxytocin ,Internal medicine ,medicine ,business ,Receptor ,medicine.drug - Abstract
Since 30 years the rate of preterm deliveries of 7% remained unchanged. This is due to a lack of understanding of the underlying pathomechanisms of preterm labor. Oxytocin (OT) as well as its receptor (OTR) play a key role in the process of (preterm) labor as part of a paracrine system that regulates myometrial contractility. Binding of OT to its corresponding receptor, OTR, leads to activation of actin-myosin interactions and therewith myometrial contractions as well as production of intrauterine prostaglandins (PGE(2), PGF(2 alpha)) mainly in decidua and myometrium. Oxytocin expression increases significantly at time of parturition, as does the expression of its receptor. Both can be influenced by diverse cellular substrates. The focus of our research group is based on the exploration of the influence of cytokines on OTR signaling.
- Published
- 2003
15. Cerebrovascular events in 21 105 patients with atrial fibrillation randomized to edoxaban versus warfarin: Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48
- Author
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Dougal, K., Venkataraman, A., Murdoch, D., Blagden, M., Dunn, S., MacCallum, P., Young, G., Lip, G., Senior, R., Brown, R., Sopher, M., Ebano, P., Linker, N., Atkinson, C., Lindsay, S., MacLeod, M., More, R., Ramasamy, V., Chapman, O., Lie, F., Beeton, I., McGhee, C., Wilmott, R., Dickinson, D., Douglas, H., Davies, D., D'Costa, D., Finlayson, M., Wright, A., Avery, D., Wright, L., Pye, M., Marazzi, P., Flint, L., Newby, D., Kennard, S., Andrews, A., Storey, R., Helliwell, L., Bridge, C., Choy, A., Turner, W., Walker, M., Wright, J., Smith, S., Jones, D., Maxwell, T., Chung, A., Isted, C., Cohen, A., Camm, J., Price, R., Watkin, R., Gilchrist, M., Duff, J., Aggarwal, R., Eldred, R., Adler, P., Chehayeb, R., Vandekerckhove, Y., Gordon, L., Jones, S., Young, C., Coyle, G. Stagi, Ferguson, D., Lang, J., Simmons, T., Langevin, E., Faucett, S., Ledbetter, L., Royse, H., Lentz, M., Smith, D., Lesser, M., Hartley, L., Lewis, D., Bonds, C., Lillestol, M., Miller, D., Ling, L., Murphy, R., Littlefield, R., Wofford, E., Lomnitz, D., Shah, D., Lone, B., Davids, M., Looby, R., Ault, S., Lui, H., Wright, H., Lurie, M., Edelstein, J., Macomber, J., Bush, D., Magee, A., Doctor, A., Mainigi, S., Lisiecki, B., Makam, S., Casas, R., Mandviwala, M., Hernandez, S., Marar, I., Rabadi-Marar, D., Marenberg, M., Bedenko, E., Massin, E., Hicks, T., McCartney, M., Stubbs, L., McGarvey, J., Schwarz, L., McGuire, K., Miranda, J., McKenzie, M., Rodkey, K., McKnight, T., Paul, J., McLaurin, B., Lack, A., Mega, J., Marti, J., Meholick, A., Skinner, J., Mehrle, A., Wall, J., Mendelson, R., Cervellione, K., Mercado, A., Cajulis, C., Michlin, B., Romero-Colon, J., Milas, J., Sanders, D., Miller, R., Sanchez, S., Miller, S., Gryczan, J., Mody, F., Strugatsky, S., Moran, J., Garner, S., Morledge, J., Bowman, B., Mouhaffel, A., Parrott, N., Mounsey, P., Schuler, C., Mowdy, M., Todd, S., Mullen, P., Raziano, S., Murphy, A., Oehmann, V., Nadar, V., Parker, A., Naidu, J., West, M., Nallasivan, M., Goza, J., Nguyen, T., Nomanee, S., Nielsen, R., Wilmot, M., Oberoi, M., Thakkar, N., Oppenheimer, K., McCormick, J., Orchard, R., Garcia, L., Osborne, J., Gonzalez, M., Oza, S., Joseph, L., Patnam, S., Dennison, K., Pavon, H., Gorry, N., Pearlstein, R., Montayne, S., Pentz, W., Duncan, D., Peters, P., Chacon, L., Petruzziello, F., Morlando, F., Pettis, K., Brown, F., Pezzella, S., Kirk, D., Poulathas, A., Cush, S., Pratt, R., Neeper, L., Pribble, A., Lowe, K., Pudi, K., Sham, L., Pugeda, J., Ebert, J., Quadrel, M., Rafla, E., Quinlan, E., Reed, C., Quinn, J., Hemmen, C., Rama, P., Domingo, D., Redondo, V., Wroblewski, J., Renzi, M., Stanley, E., Richwine, R., Pazier, P., Roberts, J., Riofrio, K., Braun, D., Robinson, J., Cherrico, M., Roehll, W., Hollihan, P., Rosado, J., Barnhorst, M., Rosen, R., Martin, C., Ross, S., Freeman, R., Ruoff, G., Nelson, T., Sacco, J., Ball, E., Samal, A., Schomburg, J., Sandberg, J., Lafave, J., Savin, V., Clifton, R., Schaefer, S., Fekete, A., Schneider, R., Schneider, W., Schulman, D., Mercer, S., Seals, A., Ullig, T., Holt, A., Seide, H., Mather, N., Shah, G., Witt, P., Shalaby, A., Seese, M., Shanes, J., Fleets, J., Shaoulian, E., Hren, A., Sheikh, K., Hengerer, T., Shih, H., Browning, J., Shoukfeh, M., Stephenson, L., Siler, T., Champagne, M., Simpson, P., Meyer, R., Singh, N., Turner, K., Singh, V., Nelson, M., Skierka, R., Hughes, B., Keene, R., Smith, R., Hodnett, P., Spangenthal, S., Thomason, L., Sperling, M., Vasquez, E., Spivack, E., McCartney, P., Staniloae, C., Liu, M., Steljes, A., Cox, C., Struble, R., Vittitow, T., Suresh, D., Frost, J., Swerchowsky, V., Freemyer, D., Szulawski, I., Herwehe, S., Tahirkheli, N., Springer, K., Takata, T., Bruton, T., Talano, J., Leo, L., Tami, L., Corchado, D., Tatarko, M., Swauger, M., Tawney, K., Dastoli, K., Teague, S., Young, K., Tee, H., Mitchell, T., Teixeira, J., Southam, D., Torres, M., Romero, N., Tucker, P., Salas, L., Updegrove, J., Hanna, K., Val-Mejias, J., Harrelson, K. Gonzalez, Vemireddy, D., Cardoza, T., Verma, S., Parsons, T., Vicari, R., Warren, K., Vijay, N., Washam, M., Vossler, M., Kilcup, S., Walsh, R., Renaud, K., Ward, S., Locklear, T., Waxman, F., Sanchez, G., Weiss, R., St Laurent, B., Westcott, J., Truva, C., Williams, D., Gibson, C., Williams, R., Dowling, C., Willis, J., VonGerichten, S., Wood, K., Capasso-Gulve, E., Worley, S., Pointer, S., Yarows, S., Sheehan, T., Yasin, M., Preston, S., Yi, J., Dongas, B., Yousuf, K., Fisher, M., Zakhary, B., Curtis, S., Zeig, S., Mason, T., Zellner, C., Harden, M., Roper, E., Waseem, M., Grammer, M., Ruff, Christian T., Giugliano, Robert P., Beerts, C., Vrolix, M., Mestdagh, I., Vervoort, G., van Welden, J., Vanwelden, J., Derycker, K., Jacobs, C., Stockman, D., Huyberechts, D., Scavee, C., Clinckemaille, N., Parque, J., Raepers, M., Mairesse, G., Malmendier, D., Herzet, J., Meeusen, K., Heidbuchel, H., Tincani, G., Desfontaines, P., De Bruyne, L., De Tollenaere, M., de Koning, K., De Bleecker, J., Banaeian, F., Capiau, L., O'Shea, V., Szto, G., Perrett, L., Purnell, P., Batta, C., Paul, V., Li, J., McKeirnan, M., George, F., Valentine, H., Gerber, J., Hinchion, N., Morrison, H., Lehman, R., Gates, P., Flecknoe-Brown, S., Silver, G., Davis, S., Kay, S., Dart, A., Slattery, A., Crimmins, D., Price-Smith, S., Colquhoun, D., Hoffmann, B., Arstall, M., Paraskevaidis, T., Anderson, C., Morell, Y., Vico, M., Teves, M., Sosa Liprandi, M., Morara, P., Severino, P., Buzzetti, C., Schygiel, P., Goloboulicz, A., Schmidberg, J., Formoso, I., Saravia Toledo, S., Codutti, O., Sanjurjo, M., Gillespie, E., Keane-Richmond, P., Gogia, H., Ewing, B., Goldscher, D., Latteri, J., Goldstein, M., Bowen, L., Sanchez, A., Alvarez, M., Rodriguez, M., Navarrete, S., Ramos, H., Venturini, C., Prado, A., Fernandez, E., Pozzer, D., Casares, E., Povedano, G., Tommasi, A., Piskorz, D., Verdini, E., Nul, D., Gandur, H., Muntaner, J., Funes, I., Marino, J., Calderon, M., Manuale, O., Carne, M., Mackinnon, I., Raimondi, G., Lotti, J., Shatsky, K., Lorente, C., Vignau, S., Llanos, J., Nigro, A., Litvak, B., Iglesias, M., Liniado, G., Belcuore, M., Lanternier, G., Monaco, F., Kevorkian, R., Jure, D., Jure, H., Bianchini, M., Hominal, M., von Wulffen, M., Goicoechea, R., Huerta, M., Giannaula, R., Eden, M., Giacomi, G., Ceirano, C., Garrido, M., Perlo, D., Garcia Duran, R., Meiller, F., Gant Lopez, J., Zanotti, A., Fuselli, J., Arrieta, M., Femenia, F., Iriarte, M., Falu, E., Facello, M., Facello, A., Davolos, M., Estol, C., Moreno, V., Dran, R., Cendali, G., D'Amico, A., Bocanera, M., Cuneo, C., Rosell, M., Cuello, J., Morandini, M., Colombo, H., Saa Zarandon, R., Caruso, O., Novas, V., Cartasegna, L., Fracaro, V., Caccavo, A., Saravia, M., Bustamante Labarta, G., Valle, M., Budassi, N., Berli, M., Petrucci, J., Beloscar, J., Caceres, M., Amuchastegui, M., Ameriso, P., Ameriso, S., Garcia, M., Alvarez, C., Reguero, M., Allall, O., Rosales, E., Albisu, J., Ahuad Guerrero, R., Gonzalez, C., 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L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Han, R. J., Zhao, R. P., Kang, H., Zhang, Z., Lin, Y. N., Zhang, H. Q., Qiang, H., Everhart, B., DeSalle, D., Fahmy, R., Watkins, D., Yuan, Z. Y., Li, L. L., Yu, B., Xu, Y. P., Yin, Y. H., Gao, M., Zheng, Y., Feld, L., Zheng, X., Tameron, A., Feldman, J., Tang, N., Felten, W., Yang, Y. J., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Liao, D. N., Liu, Y., Prior, J., Fialkow, J., Calvo, M., Li, Z. Q., Liu, B., Finkel, M., Shriver, D., Finkelstein, S., Fischell, T., Drew, B., Fishbein, G., Donahue, S., Flores, E., Slayton, C., Forman, S., Solis, A., Frais, M., Thrope, C., Franco, M., Gentry, P., French, W., Morales, C., Friedlander, I., Smith, K., Gaffney, M., Jones, J., Li, W. M., Kong, Y. Q., Li, T. F., Liu, H., Li, L., Qu, Z., Jiang, X. J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. L., Bai, F., Grandon Azua, M., Yovaniniz, P., Lara Lara, C., Stockins, B., Campisto, Y., Zapata Staub, J., Potthoff, S., Torres Carrasco, G., Pincetti, C., Carmona Perez, M., Opazo, M., Romero Llamas, R., Martinez, D., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Lopetegui, M., Arratia Diaz, P., Florenzano, F., Parada, A., Corbalan, R., Obreque, C., Cobos, J., Mondaca Mondaca, P., Bugueno, C., Retamal Matus, L., Balboa, W., Mabee, J., Woodford, T., Caterini, T., Wharton, S., Morley, A., Wahby, R., Giesbrecht, L., Velthuysen, G., Teitelbaum, J., Teitelbaum, I., Tremblay, M., Talbot, P., David, D., Talajic, M., Bobbie, C., Syan, G., Kailey, P., Sussman, J., Morissette, A., St-Hilaire, R., Silverio, G., Shu, D., Marchand, C., Rupka, D., Bozek, B., Ricci, J., Nethercott, C., Qureshi, A., Turri, L., Polasek, P., Sardin, V., Pesant, Y., Carroll, L., Parkash, R., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Garb, J., Najarali, A., Krider, J., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Malette, P., Matthews, J., MacCallum, C., Seib, M., Ma, P., Douglas, S., Luton, R., Roberts, P., Lichtenstein, T., Lam, H., Lam, S., St-Germain, L., Lainesse, A., Dewar, C., Labonte, R., Roy, M., Kouz, S., Perkins, L., Huynh, T., Standring, R., Hoag, G., Ho, V., Ho, K., Scott, L., Heath, J., Hatheway, R., Houbraken, D., Viau, C., Fortin, C., Zondag, M., Eikelboom, J., Dufresne, M., Kubanska, A., du Preez, M., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., and Wollaert, B.
- Subjects
Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,medicine.drug_class ,Pyridines ,Factor Xa Inhibitor ,Infarction ,chemistry.chemical_compound ,Double-Blind Method ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,Dose-Response Relationship, Drug ,business.industry ,Anticoagulant ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,medicine.disease ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Background and Purpose— The once-daily oral factor Xa inhibitor, edoxaban, is as effective as warfarin in preventing stroke and systemic embolism while decreasing bleeding in a phase III trial of patients with atrial fibrillation at moderate–high stroke risk. Limited data regarding cerebrovascular events with edoxaban were reported previously. Methods— We analyzed the subtypes of cerebrovascular events in 21 105 patients participating in Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48 (ENGAGE AF-TIMI 48) comparing outcomes among patients randomized to warfarin versus 2 edoxaban regimens (high dose, low dose). The primary end point for this prespecified analysis of cerebrovascular events was all stroke (ischemic plus hemorrhagic), defined as an abrupt onset of focal neurological deficit because of infarction or bleeding with symptoms lasting ≥24 hours or fatal in Results— Patients randomized to high-dose edoxaban had fewer strokes on-treatment (hazard ratio, 0.80; 95% confidence interval, 0.65–0.98) than warfarin (median time-in-therapeutic range, 68.4%); patients in the low-dose edoxaban group had similar rates (hazard ratio, 1.10 versus warfarin; 95% confidence interval, 0.91–1.32). Rates of ischemic stroke or transient ischemic attack were similar with high-dose edoxaban (1.76% per year) and warfarin (1.73% per year; P =0.81), but more frequent with low-dose edoxaban (2.48% per year; P Conclusions— In patients with atrial fibrillation, once-daily edoxaban was as effective as warfarin in preventing all strokes, with significant reductions in various subtypes of intracranial bleeding. Ischemic cerebrovascular event rates were similar with high-dose edoxaban and warfarin, whereas low-dose edoxaban was less effective than warfarin. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
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- 2014
16. Respiratory diseases are associated with molar-incisor hypomineralizations
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Kühnisch J, Mach D, Elisabeth Thiering, Brockow I, Hoffmann U, Neumann C, Heinrich-Weltzien R, Cp, Bauer, Berdel D, von Berg A, Koletzko S, Garcia-Godoy F, Hickel R, Heinrich J, and Gini, Plus Study Group
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Infant, Newborn ,Infant ,Causality ,Cohort Studies ,Breast Feeding ,Child, Preschool ,Germany ,Educational Status ,Humans ,Dental Enamel Hypoplasia ,Tobacco Smoke Pollution ,Prospective Studies ,Child ,Respiratory Tract Infections ,Follow-Up Studies - Abstract
SUMMARY The objective of our study was to evaluate the association of molar-incisor hypomineralizations (MIHs) with prospectively collected potential causative factors from the first 4 years of life, e.g. respiratory diseases, breastfeeding, maternal smoking and parental education. A total of 692 children (10 years old) from the GINI birth cohort study participated. The dental examination included the registration of enamel hypomineralizations (EHs) according to the EAPD criteria. Children with EH were sub-categorized into those with at least one EH (MIH/1), those with a minimum of one EH on at least one first permanent molar (MIH/2) and those with EH on at least one first permanent molar and a permanent incisor (MIH/3). All relationships between causative factors and caries or MIH were evaluated using simple and multiple logistic regression analyses. EHs were observed in 37.9% (MIH/1), 14.7% (MIH/2) and 9.2% (MIH/3) of all subjects. After adjustment for confounding factors, 10-year-old children with at least one episode of respiratory disease had a significantly higher risk (2.48 times, adjusted OR) for the development of MIH/3. In case of breastfeeding, a non-significant association was observed. None of the tested factors was associated with either MIH/1 or MIH/2. Early respiratory diseases seem to be directly or indirectly related to MIH/3 only. The role of (systemic) medications used for treatment of these diseases needs to be investigated in future studies.
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- 2014
17. Urinary excretion of apo(a) in patients after kidney transplantation
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Rainer Oberbauer, Bruno Watschinger, Thomas Stefenelli, Hoffmann U, Gerald Maurer, and Karam Kostner
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Male ,medicine.medical_specialty ,Renal function ,chemistry.chemical_compound ,Reference Values ,Internal medicine ,medicine ,Humans ,Postoperative Period ,Apolipoproteins A ,Aged ,Transplantation ,Kidney ,Creatinine ,biology ,business.industry ,Continuous ambulatory peritoneal dialysis ,Lipoprotein(a) ,Middle Aged ,medicine.disease ,Kidney Transplantation ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Nephrology ,biology.protein ,Female ,business ,Nephrotic syndrome ,Kidney disease - Abstract
case controlled studies [2‐6 ]. Protein and cDNA Background. Increased plasma Lipoprotein (a) (Lp(a)) sequencing of apo(a) revealed a high degree of homolevels are strongly associated with premature cardio- logy to plasminogen [7] and by inhibiting plasminogen vascular disease and stroke. The kidney is purported activation in a template-dependent manner, Lp(a) was to play an important role in apo(a) catabolism. found to inhibit fibrinolysis [8]. Lp(a) also has a high Therefore we investigated plasma Lp(a) levels in rela- aYnity for proteoglycans, which is probably the reason tion to kidney function and urinary apo(a) excretion. why it is found in high amounts in atherosclerotic Methods. One hundred and sixteen kidney transplant plaques [9]. Therefore Lp(a) has become one of the patients with normal or impaired renal function and most widely studied lipoproteins in atherosclerosis 109 age- and sex-matched healthy controls were investi- research. Despite this flurry of activity in Lp(a) gated. Plasma Lp(a) and urinary apo(a) levels were research, little is known about its physiological funcdetermined immunochemically and all other para- tion and catabolism. Lp(a) has been shown to bind to meters were determined by routine laboratory methods. the LDL-receptor in vitro, yet in vivo LDL-receptorResults. Transplant recipients were found to have sig- mediated catabolism seems to play only a minor role nificantly elevated total cholesterol and LDL-C values, in the removal of Lp(a) [10]. but equal HDL-C values compared to controls. Plasma There are several indications that the kidney plays Lp(a) values were higher and urinary apo(a) excretion an important role in Lp(a) metabolism. Following the was lower in transplant recipients compared to con- first report by Parra et al. in 1987 [11], various trols, independent of renal function. When the patient publications have appeared with the unanimous finding group was subdivided into ‘normal’ and ‘impaired that patients with uraemia and nephrotic syndrome creatinine clearance’, only the latter group secreted less have a three- to fivefold increase in their plasma Lp(a). apo(a) than normal controls. Patients with nephrotic syndrome, for example, exhibit Conclusion. These data suggest that urinary apo(a) excessively high plasma Lp(a) concentrations, which excretion is reduced in transplant recipients with can be reduced by antiproteinuric therapies [12‐14]. impaired excretory graft function, which may contrib- Patients with end-stage renal disease ( ESRD) treated ute to the elevation of plasma Lp(a) levels in these with haemodialysis are also found to have elevated patients. Lp(a) levels and these are even higher in patients treated with continuous ambulatory peritoneal dialysis
- Published
- 1997
18. Erste Erfahrungen bei Elektronenstrahl-CT-Untersuchungen des Herzens - ein Vergleich zu Herzkatheter und echokardiographischen Daten
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Weber P, Sylvia H. Heywang-Köbrunner, S. Kösling, H.-G. Schulz, Lieberenz S, Rother T, and Hoffmann U
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medicine.medical_specialty ,Electron Beam Computed Tomography ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Coronary artery patency ,medicine.disease ,Surgery ,Coronary arteries ,medicine.anatomical_structure ,Internal medicine ,Angiography ,Heart catheterization ,cardiovascular system ,medicine ,Cardiology ,Radiology, Nuclear Medicine and imaging ,Myocardial infarction ,business ,Perfusion - Abstract
AIM To evaluate the diagnostic value of ultrafast CT in comparison to established methods in cardiology. MATERIAL AND METHODS Cine and flow studies were performed in 30 patients with cardiac diseases on evolution CT. Cardiac structure and function were analysed visually and quantitatively (left ventricular ejection fraction, left ventricular myocardial mass, patency of coronary arteries, perfusion of left ventricular myocardium). The CT findings were compared with echocardiographic and angiographic findings. RESULTS Cardiac structure, functional parameters and disorders of myocardial contraction were clearly detectable by ultrafast CT, which proved inferior in assessing cardiac valves. The patency of the first and second third of normal main coronary arteries could be estimated correctly. The estimation of the distal third, of obstructed coronary arteries and of the role of collaterals was impossible. Ten of 16 areas of myocardial infarction showed low or no enhancement. CONCLUSIONS Ultrafast CT excellently reflects cardiac structure and function. It is an alternative to echocardiography. In view of the results of coronary artery patency one can hope that part of cardiac catheterisation would be avoidable in future.
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- 1995
19. Koronarkalksuche am Ultrafast-CT im Vergleich zur Koronarangiographie
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S. Kösling, Hoffmann U, Sylvia H. Heywang-Köbrunner, Lieberenz S, H.-G. Schulz, and Rother T
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medicine.medical_specialty ,business.industry ,medicine.disease ,Surgery ,Coronary artery disease ,Coronary arteries ,Stenosis ,medicine.anatomical_structure ,Internal medicine ,Coronary artery calcification ,Cardiology ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,Calcification - Abstract
The angiographical findings of 24 patients with coronary artery disease were compared with qualitative and quantitative detection of coronary calcification by ultrafast CT. Doubts concerning the capabilities of the ultrafast CT for a screening of coronary artery disease arise when the results of one third false positive and false negative findings are considered. Variations in the quantification of coronary calcification were too great to allow a realistic assessment of the degree of stenosis of the coronary arteries.
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- 1994
20. The German Infant Nutritional Intervention Study (GINI) for the preventive effect of hydrolyzed infant formulas in infants at high risk for allergic diseases. Design and selected results
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Dietrich Reinhardt, E. Wichmann, Hoffmann U, Sybille Koletzko, Joachim Heinrich, A. Grübl, Ursula Krämer, Dietrich Berdel, Elke Link, C.P. Bauer, Birgit Filipiak-Pittroff, von Berg A, and C. Beckmann
- Subjects
education.field_of_study ,Pediatrics ,medicine.medical_specialty ,Allergy ,business.industry ,Incidence (epidemiology) ,Hypoallergenic infant formula ,Population ,primary allergy prevention ,General Engineering ,Breastfeeding ,Hypoallergenic ,birth cohort ,prospective ,Cohort ,medicine ,General Earth and Planetary Sciences ,Cumulative incidence ,double-blind, randomised intervention study ,Family history ,education ,business ,hypoallergenic infant formula ,General Environmental Science ,Research Article - Abstract
In the complex interaction between certain environmental factors and genetic disposition, the early allergen exposure plays a major role in the development of allergic diseases. In aiming to reduce the allergen burden for the infant at risk during early infancy, cow's milk protein hydrolysate infant formulas (hypoallergenic infant formulas) are appropriate alternatives to breastfeeding for primary allergy prevention. The German Infant Nutritional Intervention-Program (GINI) was supported for the first 3 years by the German Ministry for Education and Research (BMBF) (FKZ 01 EE 9401-4). It is a birth cohort which was primarily scheduled until the children were 3 years old. The aim of the prospective, randomized, double-blind intervention study was to investigate the impact of different cow's milk protein hydrolysate infant formulas in the first 4 - 6 months on the development of allergic diseases in children at risk due to at least one parent or biological sibling with a history of allergic disease. The allocation to one of the 4 intervention formulas (partial whey hydrolysate, extensive whey hydrolysate, extensive casein hydrolysate or standard cow's milk formula) was randomised and stratified by family history (single/biparental) and the respective obstetric clinic. Recruitment was carried out by the three clinical centers (Research Institute Marien-Hospital Wesel, Children's Department, Ludwigs-Maximilians-University Munich and Children's Department Technical University Munich) in 18 obstetric clinics between 01.09.1995 and 30.06.1998. Along with the intervention study a non-interventional, complementary observational cohort of children with or without allergy risk was recruited and followed by annual self-reporting parental questionnaires. The GINI intervention study (GINI-I, N = 2.252) and the non-interventional observation study (GINI-NI, N = 3.739) are combined in the population-based GINIplus study (see article J. Heinrich et al. in this journal). The results of the GINI intervention study confirm that, cow's milk protein hydrolysate infant formulas have a preventive effect on allergic manifestation compared with a standard cow's milk formula, until school age. However, the dimension of the effect is different between the formulas. This effect, which is mainly driven by the effect on atopic eczema, develops in the first months of life and persists without rebound. In the formula groups the cumulative incidence of atopic eczema until school age is reduced between 26% and 45% compared with standard cow's milk formula. A beneficial effect of the hydrolysate formulas on the respiratory manifestations asthma and rhinoconjunctivitis, however, could not be shown. By comparing the GINI intervention and non-intervention arm of the GINIplus study it was demonstrated, that a family history for allergy doubles the risk for eczema in the offspring. Early intervention with cow's milk protein hydrolysate infant formulas is able to substantially compensate this risk for eczema until the age of 6 years. In contrast, by randomization to standard cow's milk formula this risk showed a trend towards a higher incidence compared with children at risk from the non-intervention group. Thus, the results of the GINIplus study have contributed to answer some of the controversially discussed questions.
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- 2011
21. FOXP3+ regulatory T-cells in renal allografts: correlation with long-term graft function and acute rejection
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Kollins D, Stoelcker B, Hoffmann U, Tobias Bergler, Reinhold S, Mc, Banas, Rümmele P, Farkas S, Bk, Krämer, and Banas B
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Graft Rejection ,Male ,Time Factors ,Biopsy ,Graft Survival ,Fluorescent Antibody Technique ,Forkhead Transcription Factors ,Middle Aged ,Kidney ,Kidney Transplantation ,T-Lymphocytes, Regulatory ,CD4 Lymphocyte Count ,Treatment Outcome ,Creatinine ,Germany ,Acute Disease ,Humans ,Transplantation, Homologous ,Female ,Transplantation Tolerance ,Prospective Studies ,Biomarkers ,Aged ,Glomerular Filtration Rate - Abstract
The interpretation of a cellular infiltrate as cytotoxic or tolerogen represents an unsolved challenge in current transplantation. The so-called regulatory CD4+ CD25+ T-cells which express the FOXP3 gene have received increasing interest with respect to this question. The existing studies concerning the role of FOXP3+ Tregs for transplant tolerance yielded contradictory results.We examined the numbers of the FOXP3+ Tregs in two groups of renal allograft biopsies both showing cellular infiltration, but either without (n=29) or with signs of acute cellular rejection (n=26), by means of immunofluorescence and correlated the amount of FOXP3+ Tregs to renal function at the time of biopsy and after 1 and 2 years of follow up.The number of FOXP3+ Tregs within infiltrates in non-rejecting biopsies did not correlate with renal function after 1 and 2 years. There were no significant differences in the numbers of FOXP3+ Tregs between biopsies with or without borderline infiltrates. Increased numbers of FOXP3+ Tregs were not associated with an ameliorated severity of graft rejection and did not correlate with outcome after the rejection episode and renal function after 1 and 2 years.The identification of the FOXP3+ regulatory cells within the allograft cannot be considered as an appropriate marker for the interpretation of infiltrates as cytotoxic or tolerogenic or as a prognostic marker for later transplant function.
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- 2011
22. Association between attendance of day care centres and increased prevalence of eczema in the German birth cohort study LISAplus
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Cramer, C., Link, E., Bauer, C.P., Hoffmann, U., von Berg, A., Lehmann, I., Herbarth, O., Borte, M., Schaaf, B., Sausenthaler, S., Wichmann, H.-E., Heinrich, J., Krämer, U., LISAplus Study Group (Wichmann, H.-E., Bolte, G., Belcredi, P., Jacob, B., Schoetzau, A., Mosetter, M., Schindler, J., Höhnke, A., Franke, K., Laubereau, B., Thaqi, A., Zirngibl, A., Zutavern, A.), and Malden, USA
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Male ,Incidence ,Eczema ,Germany, West ,Infant ,children ,day care attendance ,East ,West comparison ,eczema ,regional patterns ,Child Day Care Centers ,Social Environment ,Cohort Studies ,Risk Factors ,Child, Preschool ,Health Care Surveys ,Surveys and Questionnaires ,Absenteeism ,Prevalence ,Humans ,Female ,Germany, East ,Child ,Life Style - Abstract
Day care centre attendance is much more common in East than in West Germany. Although there is evidence that early day care might be protective against atopic diseases, several studies have shown a higher prevalence of childhood eczema in East Germany compared to West Germany. To compare prevalence and cumulative incidence of eczema in a birth cohort study in East and West Germany and to identify risk factors that are associated with eczema, which might explain regional differences. We used data from the ongoing population-based birth cohort study Influence of Life-style factors on the development of the Immune System and Allergies in East and West Germany Plus the influence of traffic emissions and genetics. In 1997, 3097 children from study areas in East and West Germany were recruited. Cumulative incidence and 1-year prevalences of eczema up to the age of 6 years were determined from yearly questionnaires. Cox regression and generalized estimating equations/logistic regression were used to quantify regional differences and to identify risk factors that might explain them. Prevalence and incidence of eczema were higher in children living in East Germany than those living in West Germany. We identified 11 risk factors that showed significant regional differences. From these factors, only 'day care attendance during the first 2 years of life' was significantly associated with eczema (odds ratio 1.56, 95% confidence interval CI 1.31-1.86). The regional differences in eczema could be explained by differences in early day care utilization. Day care centre attendance is associated with an increased prevalence and incidence of eczema. Regional differences in eczema prevalence could be explained by regional differences in utilization of early day care.
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- 2010
23. Bronchocoronary collateral circulation: clinical utility of cardiac computed tomography. Images in cardiovascular medicine
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Goetti, R, Candinas, R, Leschka, S, Hoffmann, U, Alkadhi, H, University of Zurich, and Alkadhi, H
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2737 Physiology (medical) ,10042 Clinic for Diagnostic and Interventional Radiology ,610 Medicine & health ,2705 Cardiology and Cardiovascular Medicine - Published
- 2010
- Full Text
- View/download PDF
24. Physical and chemical plasma pretreatment of indium tin oxide and influence on organic light emitting diodes
- Author
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Franke, S., May, C., Landgraf, H., Campo, M., and Hoffmann, U.
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- 2010
- Full Text
- View/download PDF
25. Validity of a swimming snorkel for metabolic testing
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Keskinen Kl, Hoffmann U, Kusch M, and Ferran A. Rodríguez
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Ecology ,Pulmonary Gas Exchange ,Physical Therapy, Sports Therapy and Rehabilitation ,Mechanics ,Simulation system ,Oxygen uptake ,Gas analyzer ,law.invention ,Respiratory Function Tests ,Europe ,Metabolism ,Oxygen Consumption ,law ,Ventilation (architecture) ,Gas analysis ,Environmental science ,Humans ,Orthopedics and Sports Medicine ,Expiratory tidal volume ,Swimming - Abstract
Two models of a swimming snorkel connected to a portable metabolic cart (Cosmed K4 b 2 , Rome, Italy) were assessed using a gas exchange simulation system. Four standardized testing protocols were designed to mimic different swimming conditions and were performed similarly in three conditions so that both snorkels could be compared to measured values obtained by connecting the simulator directly with the gas analyzer. Simulated and measured values were highly correlated (R 2 = 0.891 to 0.998) and in good agreement, with only a small overestimation of expiratory tidal volume (4 %, p = 0.005), not large enough to significantly affect the accuracy of ventilation or gas exchange parameters. Values measured using both swimming snorkels also highly correlated with simulated values, particularly for the ventilatory and primary gas exchange variables (R 2 = 0.996 and 0.998 in both models for V·O 2 and V·CO 2 , respectively). A moderate overestimation of F E O 2 was observed in both models (2.65 % and 2.48 % relative, p = 0.03) and attributed to minimal mixing of inspiratory and expiratory gases, although not affecting V·O 2 measurements. We conclude that both snorkels are valid devices for measuring pulmonary breath-by-breath gas exchange parameters in connection with the K4 b 2 across a wide physiological range.
- Published
- 2007
26. Accuracy of 16-slice multi-detector CT to quantify the degree of coronary artery stenosis: Assessment of cross-sectional and longitudinal vessel reconstructions
- Author
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Cury, RC, Ferencik, M, Achenbach, S, Pomerantsev, E, Nieman, Koen, Moselewski, F, Abbara, S, Jang, IK, Brady, TJ, Hoffmann, U, and Radiology & Nuclear Medicine
- Published
- 2006
27. Quantitative parameters of image quality in 64-slice computed tomography angiography of the coronary arteries
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Ferencik, M, Nomura, CH, Maurovich-Horvat, P, Hoffmann, U, Pena, AJ, Cury, RC, Abbara, S, Nieman, Koen, Fatima, U, Achenbach, S, Brady, TJ, and Radiology & Nuclear Medicine
- Published
- 2006
28. Der neue EHM Tauchen noch sicherer
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Ehm, O.F., Hoffmann, U., and Wenzel, J.
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Druckauswirkungen ,Tauchunfälle ,Tauchpsychologie ,Tauchausrüstung ,Dekompression ,Tieftauchen ,Tauchtauglichkeitsuntersuchung ,Tauchphysiologie ,Tauchpathophysiologie ,Langzeiteffekte - Published
- 2003
29. Vascular centers in Europe. Results of a panel discussion at the 14th Meeting of the European Chapter of the International Union of Angiology (Cologne, Germany, May 25, 2001)
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Duprez D, Allegra C, Bauersachs R, Jill JF Belch, Boccalon H, Hoffmann U, and Mahler F
- Subjects
Europe ,Evidence-Based Medicine ,Cardiovascular Diseases ,Humans ,Delivery of Health Care - Published
- 2002
30. Improved laboratory confirmation of heparin-induced thrombocytopenia type II. Time course of antibodies and combination of antigen and biologic assays
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Job Harenberg, Wang L, Hoffmann U, Huhle G, and Feuring M
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Immunoassay ,Male ,Serotonin ,Heparin ,Platelet Count ,Middle Aged ,Platelet Factor 4 ,Sensitivity and Specificity ,Thrombocytopenia ,Kinetics ,Humans ,Immune Complex Diseases ,Female ,Carbon Radioisotopes ,Antigens ,Aged ,Autoantibodies ,Fluorescent Dyes - Abstract
We studied whether laboratory confirmation of heparin-induced thrombocytopenia (HIT) can be improved after antigen clearance by determining free antibody and combining the results of an antigenic and a biologic assay. Blood samples taken over 40 days in 14 patients with HIT with thromboembolism underwent fluorescence-linked immunofiltration and the carbon 14-serotonin release assays. Of the 14 patients, 11 showed positive results in both assays at day 1 after stopping heparin. The 3 patients with negative results seroconverted in one or both assays during the subsequent 7 days. Combining the positive results of the assays increased the sensitivity from 85% at day 1 to 100% at day 7. Assay results became negative in all patients within 40 days. The platelet count normalized between days 2 and 9 after withdrawal of heparin. It is assumed that the free antibody can be detected after withdrawal of heparin and after clearance of the platelet factor 4-heparin complex in patients with HIT.
- Published
- 2001
31. Quantitation of serotonin from platelets using enzyme-immunoassay in the presence of serum from HIT-patients
- Author
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Job Harenberg, Koch S, Giese C, Lc, Wang, Hoffmann U, and Huhle G
- Subjects
Blood Platelets ,Immunoenzyme Techniques ,Serotonin ,Heparin ,Anticoagulants ,Humans ,Heparin, Low-Molecular-Weight ,Thrombocytopenia - Published
- 2000
32. Effects of Chronically Increased Ambient CO2 Concentrations on Aerobic Capacity
- Author
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Hoffmann, U., Schöllmann, C., Wackerhage, H., Leyk, D., and Wenzel, J.
- Subjects
aerobic capacity ,muscle metabolism ,CO2 exposure ,confined compartment ,cycle ergometry - Published
- 1998
33. Daempfung von Faserverbundwerkstoffen
- Author
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Hanselka, H. and Hoffmann, U.
- Published
- 1997
34. Exercise Capacity during and after Spaceflight
- Author
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Erdmann, R., Stegemann, J., Hoffmann, U., and Essfeld, D.
- Published
- 1997
35. Glycolytic ATP production during ischaemic exercise measured by 31P-MRS in vivo
- Author
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Wackerhage, H. (1), Zange, J., Müller, K., Hoffmann, U. (1), and Essfeld, D. (1)
- Subjects
magnetic resonance ,31P-MRS ,calf ,exercise ,muscle ,ischemia ,glycolysis ,metabolism - Published
- 1996
36. Analytische und experimentelle Ergebnisse zum Daempfungsverhalten polymerer Faserverbundwerkstoffe
- Author
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Hanselka, H. and Hoffmann, U.*)
- Published
- 1994
37. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
- Author
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Speliotes, E.K., Yerges-Armstrong, L.M., Wu, J., Hernaez, R., Kim, L.J., Palmer, C.D., Gudnason, V., Eiriksdottir, G., Garcia, M.E., Launer, L.J., Nalls, M.A., Clark, J.M., Mitchell, B.D., Shuldiner, A.R., Butler, J.L., Tomas, M., Hoffmann, U., Hwang, S.J., Massaro, J.M., O'Donnell, C.J., Sahani, D.V., Salomaa, V., Schadt, E.E., Schwartz, S.M., Siscovick, D.S., Voight, B.F., Carr, J.J., Feitosa, M.F., Harris, T.B., Fox, C.S., Smith, A.V., Kao, W.H., Hirschhorn, J.N., Borecki, I.B., and Heijer, M. den
- Subjects
Molecular epidemiology [NCEBP 1] ,Hormonal regulation [IGMD 6] - Abstract
Contains fulltext : 95930.pdf (Author’s version postprint ) (Open Access) Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomography (CT) measured hepatic steatosis, a non-invasive measure of NAFLD, in large population based samples. Using variance components methods, we show that CT hepatic steatosis is heritable ( approximately 26%-27%) in family-based Amish, Family Heart, and Framingham Heart Studies (n = 880 to 3,070). By carrying out a fixed-effects meta-analysis of genome-wide association (GWA) results between CT hepatic steatosis and approximately 2.4 million imputed or genotyped SNPs in 7,176 individuals from the Old Order Amish, Age, Gene/Environment Susceptibility-Reykjavik study (AGES), Family Heart, and Framingham Heart Studies, we identify variants associated at genome-wide significant levels (p
- Published
- 2011
38. Resuscitation fluid use in critically ill adults: an international cross sectional study in 391 intensive care units
- Author
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Finfer, S, Liu, B, Taylor, C, Bellomo, R, Billot, L, Cook, D, Du, B, Mcarthur, C, Myburgh, J, Jacobs, S, Gazzard, R, Edington, J, Ghelani, D, Blythe, D, Richards, B, Mccalman, C, Parr, M, Walker, C, Seppelt, I, Cole, L, Stevens, D, Cade, J, Webb, S, Woolfe, C, van Heerden PV, Cooper, J, Mitchell, I, Peake, S, French, C, Playford, H, Bannerjee, A, Berwanger, O, da Silva, N, Mario Teles, J, Guimarães, H, Rocha, M, Piras, C, Mcintyre, L, Bagshaw, Sm, Stelfox, T, Green, R, Hall, R, Son, W, Meade, M, Kumar, A, Wittman, R, Martin, C, Leblanc, M, Lim, S, Keenan, S, Magder, S, Chittock, D, Wang, W, Dong, J, Chen, X, Li, A, Zhuang, H, Liu, W, Liu, Y, He, Q, Wang, J, Zhou, N, Bai, Y, Wang, L, Lu, F, Chen, W, Wang, S, Zhou, J, Zhang, Z, Xu, Y, Li, T, Sun, X, Wang, B, Zhao, C, Song, Q, Pan, L, Ma, P, Li, Q, Li, G, Chen, D, Liu, L, Gao, K, Han, S, Wan, X, Zhang, Y, Chao, Y, Xi, X, Jiang, L, Han, C, Qin, T, Jiang, W, Li, Y, Liu, X, Hu, Z, Ding, Y, Li, W, Wang, X, Weng, L, Wang, D, Li, S, An, Y, Zhang, W, Luo, H, Luo, Y, Zhu, X, Li, H, Li, C, Qu, H, Mao, E, Min, D, Wang, C, Zhang, J, Ren, H, Liu, H, Wang, M, Zhao, M, Fei, D, Qian, C, Liu, R, Shi, B, Guo, H, Guan, X, Wu, J, Zhou, L, Yu, K, Wang, H, Wang, Y, Li, D, Huang, Q, Su, M, Dong, C, Zhang, X, Wu, B, Qin, Y, Zhang, N, Kang, Y, Deng, Y, Ai, Y, Guo, Y, Cui, Q, Jia, J, Chen, H, Yan, J, Xu, Q, Sun, R, Hong, J, Fang, Q, Zheng, X, Qiu, H, Liu, S, Zhou, Q, Li, J, Schonemann, N, Bendtsen, A, Thornberg, K, Boensen, H, Tousi, H, Bestle, M, Pawlowicz, M, Høen Beck, D, Carl, P, Ronholm, E, Welling, K, Strelitz, J, Kancir, C, Hostrup, A, Perner, A, Jensen, R, Westergard Nielsen, J, Bennett, S, Ball, A, Becker, H, Desikan, S, Watson, N, Watson, D, Smith, I, Wright, M, Millo, J, Morris, J, Williams, A, Peebles Brown, A, Grainger, K, Marsh, R, Christmas, D, Harling, D, Boulanger, C, Davenport, A, Goldsmith, A, Cook, B, Drage, S, Goodall, J, Higgins, D, Price, J, Margarson, M, Sherry, T, Mcauley, F, Syndercombe, A, Jones, G, Reid, J, Andrivet, P, Jamali, S, Rigaud, J, Gaffine, A, Kerkeni, Mejean, C, Drault, J, Beuret, P, Bourffandeau, B, Gasselin, J, de Jonghe, B, Mercat, A, Quenot, J, Broux, C, Timsit, J, Mokhtar, H, Jacobs, F, Pease, S, Mourvillier, B, Lasocki, S, Clabault, K, Rahmani, H, Cariou, A, Guerin, C, Combes, A, Duguet, A, Thuong, M, Janvier, G, Schortgen, F, Icahai, C, Megarbane, B, Payen, D, Leon, R, Gruson, D, Guidet, B, Tardu, D, Roch, A, Ridel, C, Fartoukh, M, Mentec, H, Guitton, C, Blot, F, Oppert, M, Spies, C, Gründling, M, Friesecke, S, Meier, A, Martin, J, Jaschinski, U, Gärtner, R, Weyland, W, Wappler, F, Bromber, H, Welte, T, Hadem, J, Fiedler, F, Peckelsen, C, Fritz, H, Rensing, H, Ragaller, M, Reinhart, K, Brunkhorst, Fm, Riessen, R, Gerlach, H, Hoffmann, U, Chow, Fl, Cheng, C, Joynt, G, Buckley, T, Auyeung, Kw, Young, K, Ching, Ck, Sigurdsson, S, Sigvaldason, K, Hreinsson, K, Kapadia, F, Donnelly, M, Bailie, R, Breen, D, Bates, J, Marsh, B, Motherway, C, Mcauley, D, Trinder, J, Manzoni, A, Mottura, G, Bonaccorso, G, Luzzani, A, De Blasio, E, Bonanno, R, Cardarelli, N, De Cristofaro, M, Mazzola, E, Monfregola, M, Isetta, M, Franchi, F, Trisolino, F, Marchetti, G, Piga, G, Todesco, L, Perno, S, Bianchin, A, Blasetti, A, Rossi, S, Salcuni, R, Greco, M, Beck, E, Antonini, B, Malacarne, P, Prandi, E, Negro, G, Cubeddu, G, Pasquinucci, G, Ferrari, E, Rotelli, S, Savioli, M, Mediani, T, Tognoli, E, Ribola, A, Laperchia, L, Meinardi, S, Cancellieri, F, Mancosu, S, Segala, V, Gamberini, E, Garofalo, G, Dentini, N, Carnevale, L, Bilotta, F, Brunod, F, Casagrande, L, Riva, I, Osti, D, Sitta, V, Alleva, S, Becattini, G, Munaron, S, Cavallo, R, Marzullo, A, Ferrari, F, Calicchio, G, Sucre, M, Quattrocchi, L, Breschi, C, Gratarola, A, Sciacca, P, Postiglione, M, Barattini, M, Rossi, M, Falcelli, C, Coaloa, M, Cattin, S, Palmese, S, David, Antonio, Calabrese, P, Dote, K, Ohashi, I, Morimatsu, H, Goto, Y, Hagioka, S, Mcguiness, S, Gibson, A, Henderson, S, Freebairn, R, Williams, T, Liang, J, Van Haren, F, Dinsdale, D, Serra, I, Arabi, Y, Qushmaq, I, Abouchala, N, Kherallah, M, Mandourah, Y, Cuthbertson, B, Willis, P, Cole, S, Macdougall, M, Andrews, P, Alcorn, D, Carins, C, Digby, B, Tan, Ck, Lee, P, Chan, Y, Petersen, P, Albert, J, Guldbrand, P, Juhlin Dannfeldt, M, Nielsen, N, Hjelmqvist, H, Nordlund, P, Berkius, J, Oldner, A, Konrad, D, Zatterman, R, Metcalf, K, Friberg, H, Chew, M, Lindgren, K, Aneman, A, Gatz, R, Blomqvist, H, Wizelius, I, Andersson, M, Rodling Wahlstrom, M, Stiernstrom, H, Lindgren, P, Elvstad, T, Hyddmark, U, Merz, T, Laube, M, Haberthuer, C, Jaeggi, M, Maggiorini, M, Stover, J, Ahmed, R, Kellum, J, Murugan, R, Salmon, A, Vlahakis, N, Cohn, S, and Chung, K.
- Subjects
Adult ,Male ,endocrine system ,medicine.medical_specialty ,Resuscitation ,Internationality ,Cross-sectional study ,Critical Illness ,Critical Care and Intensive Care Medicine ,complex mixtures ,Resuscitation fluid ,Intensive care ,medicine ,Humans ,Colloids ,Medical prescription ,Intensive care medicine ,Generalized estimating equation ,Aged ,critically ill adults ,business.industry ,Research ,digestive, oral, and skin physiology ,Odds ratio ,Middle Aged ,Confidence interval ,body regions ,Intensive Care Units ,Cross-Sectional Studies ,intensive care units ,Emergency medicine ,Commentary ,Fluid Therapy ,Female ,business ,Perfusion - Abstract
Introduction Recent evidence suggests that choice of fluid used for resuscitation may influence mortality in critically ill patients. Methods We conducted a cross-sectional study in 391 intensive care units across 25 countries to describe the types of fluids administered during resuscitation episodes. We used generalized estimating equations to examine the association between patient, prescriber and geographic factors and the type of fluid administered (classified as crystalloid, colloid or blood products). Results During the 24-hour study period, 1,955 of 5,274 (37.1%) patients received resuscitation fluid during 4,488 resuscitation episodes. The main indications for administering crystalloid or colloid were impaired perfusion (1,526/3,419 (44.6%) of episodes), or to correct abnormal vital signs (1,189/3,419 (34.8%)). Overall, colloid was administered to more patients (1,234 (23.4%) versus 782 (14.8%)) and during more episodes (2,173 (48.4%) versus 1,468 (32.7%)) than crystalloid. After adjusting for patient and prescriber characteristics, practice varied significantly between countries with country being a strong independent determinant of the type of fluid prescribed. Compared to Canada where crystalloid, colloid and blood products were administered in 35.5%, 40.6% and 28.3% of resuscitation episodes respectively, odds ratios for the prescription of crystalloid in China, Great Britain and New Zealand were 0.46 (95% confidence interval (CI) 0.30 to 0.69), 0.18 (0.10 to 0.32) and 3.43 (1.71 to 6.84) respectively; odds ratios for the prescription of colloid in China, Great Britain and New Zealand were 1.72 (1.20 to 2.47), 4.72 (2.99 to 7.44) and 0.39 (0.21 to 0.74) respectively. In contrast, choice of fluid was not influenced by measures of illness severity (for example, Acute Physiology and Chronic Health Evaluation (APACHE) II score). Conclusions Administration of resuscitation fluid is a common intervention in intensive care units and choice of fluid varies markedly between countries. Although colloid solutions are more expensive and may possibly be harmful in some patients, they were administered to more patients and during more resuscitation episodes than crystalloids were.
- Published
- 2010
39. Nonlinear dynamics of reactive distillation processes for the production of fuel ethers
- Author
-
Mohl, K. D., Achim Kienle, Gilles, E. D., Rapmund, P., Sundmacher, K., and Hoffmann, U.
40. Urinary apo(a) excretion is not altered by changes in glomerular filtration rate and renal plasma flow in healthy males
- Author
-
Kostner K, Clodi M, Bodlaj G, Hoffmann U, Hermann K, Gerald Maurer, Pacher R, and Wh, Hörl
- Subjects
Adult ,Male ,Analysis of Variance ,Renal Plasma Flow ,Sex Factors ,Age Factors ,Humans ,Infusions, Intravenous ,Somatostatin ,Apolipoproteins A ,Glomerular Filtration Rate ,Lipoprotein(a) - Abstract
Lipoprotein(a) (Lp(a)) is an independent risk factor for atherosclerotic disease. However, information concerning the site of Lp(a) catabolism and breakdown is scarce. Several studies have shown that, in renal insufficiency, plasma Lp(a) levels are elevated, and that after normalisation of kidney function they return to normal. We have recently shown that fragments of apo(a) are found in the urine of healthy individuals. Despite this evidence that apo (a) is excreted into the urine, the mode of excretion of apo(a) remains unclear. Since it has been reported that intravenous infusion of somatostatin can reduce glomerular filtration rate (GFR) and renal plasma flow (RPF), we analysed urinary apo(a) excretion in ten healthy volunteers receiving somatostatin infusions. The infusion of somatostatin led to reversible changes in GFR and RPF. Apo(a) excretion was constant in all 10 individuals over the entire time course when normalised for creatinine. There was a highly significant correlation between plasma Lp(a) levels and urinary apo(a) values. Changes in renal plasma flow and glomerular filtration rate did not alter urinary apo(a) excretion. We conclude that a constant amount of apo(a) is excreted into urine, depending on plasma Lp(a) levels, and that urinary apo(a) excretion is not altered by changes in GFR and RPF in healthy males.
41. From EEG Dependency Multichannel Matching Pursuit to Sparse Topographic Decomposition
- Author
-
Studer, D., Hoffmann, U., and Koenig, T.
- Subjects
dependency multichannel matching pursuit ,matching pursuit ,adaptive topographic time-frequency approximation ,energy distribution ,Physics::Medical Physics ,sparse topographic decomposition ,multichannel energy distribution ,EEG ,LTS1 ,BCI - Abstract
In this work we present a multichannel EEG decomposition model based on an adaptive topographic time-frequency approximation technique. It is an extension of the Matching Pur- suit algorithm and called Dependency Multichannel Matching Pursuit (DMMP). It takes the physiologically explainable and statistically observable topographic dependencies between the channels into account, namely the spatial smoothness of neighboring electrodes that is im- plied by the electric lead¯eld. DMMP decomposes a multichannel signal as a weighted sum of atoms from a given dictionary where the single channels are represented from exactly the same subset of a complete dictionary. The decomposition is illustrated on topographical EEG data during di®erent physiological conditions using a complete Gabor dictionary. Further the extension of the single-channel time-frequency distribution to a multichannel time-frequency distribution is given. This can be used for the visualization of the decomposition structure of multichannel EEG. A clustering procedure applied to the topographies, the vectors of the corresponding contribution of an atom to the signal in each channel produced by DMMP, leads to an extremely sparse topographic decomposition of the EEG.
42. Human-Brain Interface: Signal Processing and Machine Learning
- Author
-
Vesin, J., Hoffmann, U., and Ebrahimi, T.
- Subjects
LTS1 - Abstract
The Electroencephalogram (EEG) is a recording of the electrical potentials generated by brain activity on the scalp. It has been used for decades as a non-invasive tool both in fundamental brain research and in clinical diagnosis. But it is now widely used also in Brain-Computer Interfaces (BCI) to provide augmentative communication mainly for severely handicapped patients and, prospectively, in the general framework of human computer interaction. As in any communication system, the input (EEG activity) must be coded (feature extraction) before being sent, and the receiving device (the computer) must map the received data to actions classification). This article explores the main approaches used in the BCI community for completing these tasks.
43. Face Detection Using Discrete Gabor Jets And Color Information
- Author
-
Hoffmann, U., Jacek Naruniec, Yazdani, A., and Ebrahimi, T.
- Subjects
Colored Image Patch Model ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Face Detection ,Linear Discriminant Analysis ,Discrete Gabor Jets - Abstract
Face detection allows to recognize and detect human faces and provides information about their location in a given image. Many applications such as biometrics, face recognition, and video surveillance employ face detection as one of their main modules. Therefore, improvement in the performance of existing face detection systems and new achievements in this field of research are of significant importance. In this paper a hierarchical classification approach for face detection is presented. In the first step, discrete Gabor jets (DGJ) are used for extracting features related to the brightness information of images and a preliminary classification is made. Afterwards, a skin detection algorithm, based on modeling of colored image patches, is employed as a post- processing of the results of DGJ- based classification. It is shown that the use of color efficiently reduces the number of false positives while maintaining a high true positive rate. Finally, a comparison is made with the OpenCV implementation of the Viola and Jones face detector and it is concluded that higher correct classification rates can be attained using the proposed face detector.
44. Radiomics-based machine learning versus histogram analysis and visual assessment to identify advanced atherosclerotic lesions on coronary computed tomography angiography
- Author
-
Kolossvary, M., Karady, J., Kikuchi, Y., Ivanov, A., Schlett, C. L., Lu, M. T., Foldyna, B., Merkely, B., Hugo Aerts, Maurovich-Horvat, P., and Hoffmann, U.
45. RHEOOPTICAL FOURIER-TRANSFORM INFRARED AND RAMAN-SPECTROSCOPY OF POLYMERS (VOL 47, PG 1531, 1993)
- Author
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Hoffmann, U., Pfeifer, F., Merino, J. C., Okretic, S., José María Pastor, Rodriguezcabello, J. C., Volkl, N., Zahedi, M., and Siesler, H. W.
46. Spatial filters for the classification of event-related potentials
- Author
-
Hoffmann, U., Vesin, J., and Ebrahimi, T.
- Subjects
LTS1 - Abstract
Spatial filtering is a widely used dimension reduction method in electroencephalogram based brain-computer interface systems. In this paper a new algorithm is proposed, which learns spatial filters from a training dataset. In contrast to existing approaches the proposed method yields spatial filters that are explicitly designed for the classification of event-related potentials, such as the P300 or movement-related potentials. The algorithm is tested, in combination with support vector machines, on several benchmark datasets from past BCI competitions and achieves state of the art results.
47. 10 years' experience of interventional ASD closure with the Amplatzer septal occluder
- Author
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Fischer, G., Anselm Uebing, Hoffmann, U., Jung, O., Exarchos, A., and Kramer, H. H.
48. Direct Brain-Computer Communication Through EEG Signals
- Author
-
Garcia, G., Hoffmann, U., Vesin, J., and Ebrahimi, T.
- Subjects
LTS1
49. Candida albicans chorioamnionitis associated with preterm labor and sudden intrauterine demise of one twin: A case report
- Author
-
Friebe-Hoffmann, U., David Bender, Sims, C. J., and Rauk, P. N.
50. Computed tomographic coronary angiography: An alternative to invasive coronary angiography
- Author
-
Benjamin Chow, Hoffmann, U., and Nieman, K.
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