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Your search keyword '"Hirokawa, S."' showing total 11 results
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11 results on '"Hirokawa, S."'

1. A case of body stalk anomaly arising in the second baby of a triplet pregnancy after in-vitro fertilization and embryo transfer

Author

Futatani T, Sasaki Y, Sakai M, Saito S, Ogawa J, Tsukada K, Hirokawa S, and Uotani H

Subjects
Infertility, Adult, medicine.medical_specialty, medicine.medical_treatment, Limb Deformities, Congenital, Fertilization in Vitro, Biology, Ultrasonography, Prenatal, Limb body wall complex, Fatal Outcome, Pregnancy, medicine, Triplet Pregnancy, Humans, Abnormalities, Multiple, reproductive and urinary physiology, In vitro fertilisation, Triplets, Obstetrics, Abdominal Wall, Infant, Newborn, General Medicine, medicine.disease, Embryo Transfer, Body-stalk, Embryo transfer, embryonic structures, Pediatrics, Perinatology and Child Health, Surgery, Female, Anomaly (physics), Pregnancy, Multiple, Amniotic Band Syndrome
Abstract

We report a case of body stalk anomaly arising in the second baby of a triplet pregnancy after in-vitro fertilization and embryo transfer (IVF-ET). Body stalk anomaly or limb-body wall complex is a rare congenital anomaly with a series of similar clinical manifestations and poor prognosis. IVF-ET is an effective treatment for various types of infertility. We summarize and discuss herein the relation with the sequence of genesis for such malformations and multiple pregnancies after IVF-ET.

Published
2003

2. Expression of non-hepatic-type S-adenosylmethionine synthetase isozyme in rat hepatomas induced by 3'-methyl-4-dimethylaminoazobenzene

Author

S, Horikawa, Y, Kobayashi, T, Sugiyama, H, Terashima, K, Wada, K, Tsukada, and S ], Hirokawa S [corrected to Horikawa

Subjects
Male, Carcinogenesis, Hepatocellular carcinoma, Blotting, Western, Molecular Sequence Data, Biophysics, Biology, medicine.disease_cause, Biochemistry, Isozyme, Rats, Sprague-Dawley, Liver Neoplasms, Experimental, Structural Biology, Gene expression, Genetics, medicine, Animals, Amino Acid Sequence, RNA, Messenger, Molecular Biology, Gene, Carcinogen, chemistry.chemical_classification, Methyldimethylaminoazobenzene, Messenger RNA, Cell Biology, Methionine Adenosyltransferase, medicine.disease, S-Adenosylmethionine synthetase, Rats, Isoenzymes, Enzyme, chemistry
Abstract

It is known that a high incidence of hepatocellular carcinoma in rat liver can be induced by such azo dye carcinogens as 3′-methyl-4-dimethylaminoazobenzene (3′-MeDAB). Mammalian S-adenosylmethionine (AdoMet) synthetase exists as two isozymes, non-hepatic-type and liver-type enzymes, which are the products of two different genes. We have examined the expression of two AdoMet synthetase isozyme proteins and mRNAs in rat hepatomas induced by 3′-Me-DAB. The levels of non-hepatic-type enzyme protein and mRNA are clearly induced by 3′-Me-DAB feeding. On the other hand, the levels of liver-type enzyme protein and mRNA are nearly the same or slightly decreased during hepatocarcinogenesis. These results indicate that the expression of the non-hepatic-type isozyme gene is obviously influenced with the progression of carcinogenesis and that the non-hepatic-type isozyme is useful as a oncodevelopmental marker in the liver.

Published
1993

3. Parmacokinetics of tow rectal dosage forms after anal surgery, especially in serum level Ketoprofen under local and spinal anesthesia

Author

I Kanamoto, Hirokawa S, Fujimaki M, T. Kasagi, Takemori S, Y. Suzuki, Tazawa K, H. Arai, I Horikoshi, S. Katsuyama, and K. Yamamoto

Subjects
Ketoprofen, medicine.medical_specialty, business.industry, Anesthesia, Gastroenterology, medicine, Spinal anesthesia, Anal surgery, Surgery, business, Dosage form, medicine.drug
Abstract

経直腸的に投与される坐剤は, 腰椎麻酔下では, 局所麻酔や非麻酔患者と比較して最高血中濃度到達時間が2時間延びる.この遅延が剤形別の差によるのかどうかを検討した.用いたケトプロフィンKP坐剤は脂質坐剤 (KP-FS) とゼラチンカプセル坐剤 (KP-GCS) の2種類である.腰椎麻酔患者29名, 局所麻酔患者12名, 非麻酔患者10名の合計51名の血中濃度推移をクロマトグラフィを用いて測定した.直腸からの吸収動態では, KP-FSとKP-GCSにおいて剤形による差がなく, 腰椎麻酔患者では吸収の速度が著しく低く, 最高濃度到達時間がやはり2倍に延長した.腰椎麻酔下ではHip-flop現象が認められ, 最高濃度が低く, 鎮痛効果を得るためには投与量に注意を要し, 一方では血中持続時間が2倍に延長するため臨床上はその鎮痛効果の良好なことを裏付ける結果であった.

Published
1989
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4. Predicting future ranking of online novels based on collective intelligence

Author

Shimizu, K., EISUKE ITO, and Hirokawa, S.

Subjects
Online novel, ranking, InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL, collective intelligence, User Generated Contents
Abstract

A large number of novels are being up- loaded as online novels. The present paper proposes a ranking algorithm based on the users’ favorite lists (bookmarks). Empirical evaluation has been conducted with respect to each genre of novels. In several genres, it is confirmed that the top ranked novels in July are predicted from the bookmarks of May.

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