2,071 results on '"Himmel, A."'
Search Results
2. A Single Nucleotide Polymorphism in
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Matthew R, Alexander, Samuel, Hank, Bethany L, Dale, Lauren, Himmel, Xue, Zhong, Charles D, Smart, Daniel J, Fehrenbach, Yuhan, Chen, Nitin, Prabakaran, Brian, Tirado, Megan, Centrella, Mingfang, Ao, Liping, Du, Yu, Shyr, Daniel, Levy, and Meena S, Madhur
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Mice, Knockout ,Hypertension, Renal ,Angiotensin II ,Tryptophan ,CD8-Positive T-Lymphocytes ,Arginine ,Kidney ,Fibrosis ,Interleukin-12 ,Polymorphism, Single Nucleotide ,Mice, Inbred C57BL ,Interferon-gamma ,Mice ,Hypertension ,Animals ,Humans ,Adaptor Proteins, Signal Transducing ,Genome-Wide Association Study - Abstract
SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively regulates cytokine signaling and cell proliferation. A common missense single nucleotide polymorphism inWe used CRISPR-Cas9 technology to create mice homozygous for the major (Arg/Arg) and minor (Trp/Trp) alleles of thisTrp/Trp mice exhibit 10 mmHg higher systolic BP during chronic Ang II infusion compared to Arg/Arg controls. Renal injury and perivascular fibrosis are exacerbated in Trp/Trp mice compared to Arg/Arg controls following Ang II infusion. Renal and ex vivo stimulated splenic CD8Taken together, these results suggest that the Trp encoding allele of rs3184504 is causal for BP elevation and renal dysfunction, in part through loss of SH2B3-mediated repression of T cell IL-12 signaling leading to enhanced IFNg production.
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- 2023
3. Epidemiology and Survival of Systemic Sclerosis–Sarcoidosis Overlap Syndrome
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Megan Himmel, Meyer Balter, Zareen Ahmad, Elvira Bangert, Shafina Hasmani, Rhea Siddha, Mohammad Movahedi, and Sindhu R. Johnson
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Rheumatology ,Immunology ,Immunology and Allergy - Abstract
ObjectiveWe evaluated the epidemiology, manifestations, serology, comorbidities, and survival among patients with systemic sclerosis (SSc) with and without sarcoidosis.MethodsWe conducted a retrospective cohort study comparing patients with SSc with and without sarcoidosis. All patients fulfilled the American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for SSc. Sarcoidosis was based on physician diagnosis and/or confirmatory biopsy. The primary outcome was time from diagnosis to all-cause mortality. Survival was evaluated using Kaplan-Meier curves.ResultsWe included 1977 patients (1971 with SSc, 6 with SSc–sarcoidosis) with a SSc–sarcoidosis prevalence of 0.30%. Sarcoidosis frequently preceded SSc (66.66%). The most frequent sarcoidosis manifestations were pulmonary (66.66%), lymphadenopathy (66.66%), arthritis (50%), cutaneous (33.33%), and hepatic (16.66%). Patients with SSc and SSc–sarcoidosis had female to male sex ratios of 4.5:1 vs 5:1 and median ages of SSc onset of 48.3 vs 43.8 years, respectively. Interstitial lung disease (35% vs 66.66%) and pulmonary hypertension (24.91% vs 50%) tended to occur more frequently whereas abnormal nailfold capillaries (34.7% vs 16.66%) and digital ulcers (33.33% vs 16.66%) tended to occur less frequently among patients with SSc–sarcoidosis, but the differences were not significant. There was an increased frequency of stroke among the patients with SSc–sarcoidosis (relative risk 8.59, 95% CI 1.02-72.00). The median survival times were 23.4 years for SSc–sarcoidosis and 18.6 years for SSc, with no differences in survival curves (log-rank test,P =0.55).ConclusionSarcoidosis in SSc is rare but appears to occur more frequently than in the general population. It is associated with pulmonary, lymph node, cutaneous, joint, and hepatic involvement. Stroke occurs more frequently in patients with SSc–sarcoidosis but with no differences in survival.
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- 2023
4. Forschen mit Kindern
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Bärbel Amerein, Stefanie Greubel, Samuel Jahreiß, Ina Kaul, Sophie Klaes, and Roswitha Sommer-Himmel
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- 2023
5. Molecular and epidemiological surveillance of Plasmodium spp. during a mortality event affecting Humboldt penguins (Spheniscus humboldti) at a zoo in the UK
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Merit González-Olvera, Arturo Hernandez-Colina, Tanja Himmel, Lindsay Eckley, Javier Lopez, Julian Chantrey, Matthew Baylis, and Andrew P. Jackson
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Infectious Diseases ,Animal Science and Zoology ,Parasitology - Published
- 2022
6. Treatment satisfaction and oral health-related quality of life in patients with cleft lip and palate after secondary alveolar bone grafting
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H. Naujokat, A.-L. Himmel, E. Behrens, A. Gülses, J. Wiltfang, and H. Terheyden
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Cleft Palate ,Cross-Sectional Studies ,Bone Transplantation ,Otorhinolaryngology ,Alveolar Bone Grafting ,Patient Satisfaction ,Cleft Lip ,Quality of Life ,Humans ,Surgery ,Personal Satisfaction ,Esthetics, Dental ,Oral Surgery - Abstract
Secondary alveolar bone grafting (SABG) using autologous iliac crest cancellous bone is a standard procedure for patients with cleft lip and palate (CLP). The aim of this study was to evaluate patient satisfaction after bone grafting of the alveolar cleft. Patients who underwent SABG between 2000 and 2010 in one surgical centre were included in this cross-sectional study. Three questionnaires were used, one addressing functional and aesthetic outcomes (nine items), the second being the 14-item Oral Health Impact Profile (OHIP-G14), and the third addressing donor site morbidity. A total of 103 patients fulfilled the inclusion criteria, of whom 71 could be contacted, and 52 completed the questionnaires. The majority of the patients (98%) were satisfied with the aesthetic and functional results and reported low donor site morbidity. A significant correlation was found between scores from the patient satisfaction questionnaire and the OHIP-G14. Regarding overall patient satisfaction, the manifestation of the cleft had no significant influence. The questionnaires used allowed the assessment of subjective outcome parameters, but might not be absolutely specific and exclusive for the SABG procedure in the framework of comprehensive CLP therapy. Nevertheless, SABG using autologous iliac crest cancellous bone can be considered a highly satisfactory procedure.
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- 2022
7. A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage
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Matthew R. Alexander, Samuel Hank, Bethany L. Dale, Lauren Himmel, Xue Zhong, Charles D. Smart, Daniel J. Fehrenbach, Yuhan Chen, Nitin Prabakaran, Brian Tirado, Megan Centrella, Mingfang Ao, Liping Du, Yu Shyr, Daniel Levy, and Meena S. Madhur
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Physiology ,Cardiology and Cardiovascular Medicine - Abstract
Background: SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively regulates cytokine signaling and cell proliferation. A common missense single nucleotide polymorphism in SH2B3 (rs3184504) results in substitution of tryptophan (Trp) for arginine (Arg) at amino acid 262 and is a top association signal for hypertension in human genome-wide association studies. Whether this variant is causal for hypertension, and if so, the mechanism by which it impacts pathogenesis is unknown. Methods: We used CRISPR-Cas9 technology to create mice homozygous for the major (Arg/Arg) and minor (Trp/Trp) alleles of this SH2B3 polymorphism. Mice underwent angiotensin II (Ang II) infusion to evaluate differences in blood pressure (BP) elevation and end-organ damage including albuminuria and renal fibrosis. Cytokine production and Stat4 phosphorylation was also assessed in Arg/Arg and Trp/Trp T cells. Results: Trp/Trp mice exhibit 10 mmHg higher systolic BP during chronic Ang II infusion compared to Arg/Arg controls. Renal injury and perivascular fibrosis are exacerbated in Trp/Trp mice compared to Arg/Arg controls following Ang II infusion. Renal and ex vivo stimulated splenic CD8 + T cells from Ang II-infused Trp/Trp mice produce significantly more interferon gamma (IFNg) compared to Arg/Arg controls. Interleukin-12 (IL-12)-induced IFNg production is greater in Trp/Trp compared to Arg/Arg CD8 + T cells. In addition, IL-12 enhances Stat4 phosphorylation to a greater degree in Trp/Trp compared to Arg/Arg CD8 + T cells, suggesting that Trp-encoding SH2B3 exhibits less negative regulation of IL-12 signaling to promote IFNg production. Finally, we demonstrated that a multi-SNP model genetically predicting increased SH2B3 expression in lymphocytes is inversely associated with hypertension and hypertensive chronic kidney disease in humans.. Conclusions: Taken together, these results suggest that the Trp encoding allele of rs3184504 is causal for BP elevation and renal dysfunction, in part through loss of SH2B3-mediated repression of T cell IL-12 signaling leading to enhanced IFNg production.
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- 2022
8. Role of private prescriptions in the long‐term use of benzodiazepines and Z‐drugs: A patient‐related follow‐up study
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Thomas Grimmsmann and Wolfgang Himmel
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Epidemiology ,Pharmacology (medical) - Abstract
To analyse (1) how often patients insured under the statutory health insurance (SHI) scheme received repeated prescriptions for benzodiazepines or Z-drugs as private prescriptions and (2) how often doctors switched from SHI prescriptions to private prescriptions and vice versa when issuing repeat prescriptions.On basis of anonymized prescriptions from 874 ambulatory practices in Germany, we analysed the percentage of private prescriptions for Z-drugs, benzodiazepines/anxiolytics, and benzodiazepines/hypnotics and sedatives over 6 years (2014 to 2020).Of 2 200 446 prescriptions for a benzodiazepine or Z-drug, 38% were private prescriptions. In case of Z-drugs, the rate of private prescriptions was 44.1% for single prescriptions and 48.9% for refills. The difference was smaller for anxiolytics (23.3% vs. 26.0%) and, for benzodiazepine/hypnotics and sedatives, the proportion of private prescriptions for refills was even lower than for single prescriptions. In case of Z-drugs, the proportion of private prescriptions was, on average, 42.7% for the first prescription of a series of repeat prescriptions and 49.6% for the tenth prescription. The increase was smaller for anxiolytics and negligible for benzodiazepine/hypnotics and sedatives. Doctors stayed with their initial decision in more than three quarters of repeat prescriptions, be it a SHI or private prescription.While we observed a large number of private prescriptions for benzodiazepines and Z-drugs, the proportion was only slightly higher for refills than for single prescriptions. Doctors do not seem to issue private prescriptions as a strategy to mask especially long-term use of these substances.
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- 2022
9. Früherkennung primärer Sprachentwicklungsstörungen – zunehmende Relevanz durch Änderung der Diagnosekriterien?
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Christiane Kiese-Himmel
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Public Health, Environmental and Occupational Health - Abstract
ZusammenfassungSprachentwicklungsstörungen (SES) sind die häufigsten Entwicklungsstörungen im Kindesalter. Die „primären SES“ (Prävalenz etwa 7 %) werden im Unterschied zu „sekundären SES“ nicht durch andere Entwicklungsstörungen bzw. Erkrankungen (mit-)verursacht. In der deutschen Modifikation der Internationalen Statistischen Klassifikation der Krankheiten und verwandter Gesundheitsprobleme (ICD-10-GM-22) werden die primären SES als „Umschriebene Entwicklungsstörungen des Sprechens und der Sprache“ (USES) bezeichnet, wobei u. a. ein Intelligenzquotient (IQ) Deutschsprachige Sprachtherapeut*innen möchten nun den Terminus „USES“ durch „DLD“ ersetzen und dabei die Diagnosekriterien verwenden, die vom internationalen CATALISE-Consortium (Criteria and Terminology Applied to Language Impairments Synthesizing the Evidence) vorgeschlagen werden, in deren Bestreben, eine Neubestimmung des Störungsbildes vorzunehmen. Nach dieser Konzeption werden jedoch nur Kinder mit einer geistigen Behinderung (IQ Derzeit erfolgen Diagnostik (und Therapie) meist relativ spät. Der Ausweg könnte in der Anwendung neurobiologischer Parameter liegen. Dazu werden jedoch weitere Studien benötigt, die Kinderkohorten in einem prospektiven longitudinalen Design auf Frühindikatoren untersuchen. Auch die Bildung eines Früherkennungsindex aus mehreren Indikatoren ist zu erwägen.
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- 2022
10. Quantitative Electromerism of a Well‐defined Mononuclear Copper Complex Through Reversible Intramolecular Metal‐Ligand Electron Transfer
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Johanna Osterbrink, Petra Walter, Simone Leingang, Hanna Pfisterer, Elisabeth Kaifer, and Hans‐Jörg Himmel
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Organic Chemistry ,General Chemistry ,Catalysis - Published
- 2023
11. Data from A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor–Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention
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James P. Allison, Javid J. Moslehi, Justin M. Balko, Joe-Elie Salem, Padmanee Sharma, Lauren I.R. Ehrlich, Jing Wang, Yang Zhao, Xiayu Rao, Oluwatomisin T. Atolagbe, Yu Li, Jayashree Srinivasan, Bjorn C. Knollmann, Matthew J. Wleklinski, Benedicte Lebrun-Vignes, Lauren E. Himmel, James J. Mancuso, Pierre-Yves Courand, Lorenz Lehmann, Elizabeth Whitley, Douglas B. Johnson, Elizabeth C. Wescott, Elles M. Screever, Nana-Ama A.S. Anang, Margaret L. Axelrod, Wouter C. Meijers, and Spencer C. Wei
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Immune checkpoint inhibitors (ICI) targeting CTLA4 or PD-1/PD-L1 have transformed cancer therapy but are associated with immune-related adverse events, including myocarditis. Here, we report a robust preclinical mouse model of ICI-associated myocarditis in which monoallelic loss of Ctla4 in the context of complete genetic absence of Pdcd1 leads to premature death in approximately half of mice. Premature death results from myocardial infiltration by T cells and macrophages and severe ECG abnormalities, closely recapitulating the clinical and pathologic hallmarks of ICI-associated myocarditis observed in patients. Using this model, we show that Ctla4 and Pdcd1 functionally interact in a gene dosage–dependent manner, providing a mechanism by which myocarditis arises with increased frequency in the setting of combination ICI therapy. We demonstrate that intervention with CTLA4–Ig (abatacept) is sufficient to ameliorate disease progression and additionally provide a case series of patients in which abatacept mitigates the fulminant course of ICI myocarditis.Significance:We provide a preclinical model of ICI-associated myocarditis which recapitulates this clinical syndrome. Using this model, we demonstrate that CTLA4 and PD-1 (ICI targets) functionally interact for myocarditis development and that intervention with CTLA4–Ig (abatacept) attenuates myocarditis, providing mechanistic rationale and preclinical support for therapeutic clinical studies.See related commentary by Young and Bluestone, p. 537.This article is highlighted in the In This Issue feature, p. 521
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- 2023
12. Supplementary Data from A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor–Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention
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James P. Allison, Javid J. Moslehi, Justin M. Balko, Joe-Elie Salem, Padmanee Sharma, Lauren I.R. Ehrlich, Jing Wang, Yang Zhao, Xiayu Rao, Oluwatomisin T. Atolagbe, Yu Li, Jayashree Srinivasan, Bjorn C. Knollmann, Matthew J. Wleklinski, Benedicte Lebrun-Vignes, Lauren E. Himmel, James J. Mancuso, Pierre-Yves Courand, Lorenz Lehmann, Elizabeth Whitley, Douglas B. Johnson, Elizabeth C. Wescott, Elles M. Screever, Nana-Ama A.S. Anang, Margaret L. Axelrod, Wouter C. Meijers, and Spencer C. Wei
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2 tables and 10 figures
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- 2023
13. Biosecurity Risk Assessment in the Life Sciences: Towards a Toolkit for Individual Practitioners
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Mirko Himmel
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There are a number of potential risks and unintended consequences associated with research at the intersection of biological sciences and emerging technologies, including the risk of misuse for malicious purposes. While there are established biorisk management approaches to dealing with these dangers, gaps remain. This paper focuses on the role of individual practitioners in contributing to a larger culture of biosafety and biosecurity. It presents a proposed toolkit that involves a risk assessment process and strategies to manage potential risks. The paper outlines ways to motivate practitioners to proactively take responsibility for considering and managing the biorisks associated with their work, aiming to close the knowledge gap by equipping scientists with appropriate tools to implement a comprehensive biorisk mitigation strategy at the practical level. It concludes by deploying the approach using a potential application from nanobiotechnology for demonstration purposes and considers next steps.
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- 2023
14. Correspondence
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Thomas Grimmsmann, Karel Kostev, and Wolfgang Himmel
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General Medicine - Published
- 2023
15. Solvent-Induced Redox Isomerism of Cobalt Complexes with Redox-Active Bisguanidine Ligands
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Lukas Lohmeyer, Elisabeth Kaifer, and Hans-Jörg Himmel
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Inorganic Chemistry ,Physical and Theoretical Chemistry - Abstract
Redox-isomeric coordination compounds, in which the magnetic and optical properties could be varied by a stimulated intramolecular electron transfer between the metal and a redox-active ligand, are of interest for several applications in catalysis and materials science. In this work, the redox chemistry of cobalt complexes with redox-active bisguanidine ligands is studied; systematic modifications at the redox-active bisguanidine and the co-ligand units allow for fine-tuning of the electronic structure, which eventually leads to the first observation of redox isomerism for cobalt complexes with redox-active guanidine ligands. Redox isomerism is triggered by a change in the solvent properties.
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- 2022
16. Closed-loop real-time optimization for unsteady operating production systems
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Andreas Himmel, Rolf Findeisen, and Kai Sundmacher
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Control and Systems Engineering ,Modeling and Simulation ,Industrial and Manufacturing Engineering ,Computer Science Applications - Published
- 2022
17. Erfahrungen im Umgang mit Schlafmitteln: Gruppendiskussionen mit Auszubildenden in der Pflege über Benzodiazepine und Z-Substanzen
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Wolfgang Himmel, Anne-Kathrin Kasper-Deußen, Vivien Weiß, Stephanie Heinemann, and Gabriella Marx
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030504 nursing ,Hospital setting ,Pain management ,Focus group ,Hospital care ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Action (philosophy) ,Nursing ,Spite ,Sensibility ,030212 general & internal medicine ,Sleep (system call) ,0305 other medical science ,Psychology ,General Nursing - Abstract
Experiences when handling sleep medicines: Group discussions with nursing students about benzodiazepines and Z-drugs Abstract.Background and aims: Helping patients who have difficulties falling or staying asleep is one of the challenges of hospital care. The goal of this study was to explore how nursing students experience patients' sleeping problems as well as the usage of sleep-inducing drugs, especially benzodiazepines and Z-drugs in the hospital setting. Methods: In four focus group discussions, we collected data exploring the experiences of nursing students with regards to sleeping problems and sleep-inducing drugs. The transcripts of the discussion were analysed, using documentary method. Results were finally summarized to main categories, using qualitative content analysis. Results: Students experience a generous distribution of sleep-inducing drugs, which are considered as the best possible solution for sleeping problems - in spite of weak evidence. Non-drug alternatives are seldom taught, are often unavailable on the ward and their use is rarely trained. Pharmacological knowledge is too shallow and / or the transfer of theoretical knowledge to practical action is unsuccessful. Sleep and sleeping problems, e. g. in contrast to pain management, are not a topic of priority in the hospital setting. Conclusions: More knowledge and greater sensibility about sleeping problems is needed. For example, nurses' training should incorporate knowledge about medications and non-drug alternatives and how to apply them in critical situations. Doctors and nurses should offer nursing students good role models in these situations.
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- 2022
18. Im Zentrum des Corona-Wahnsinns
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Claudia Himmel and Johanna Blöcker
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General Materials Science - Abstract
Was ist zu diesem Thema bereits bekannt? Zu Beginn der Covid-19-Pandemie war weltweit kein Wissen über das Corona-Virus und seine Verbreitungswege bekannt, was überall zu großer Verunsicherung führte. Wie wird eine neue Perspektive eingebracht? Über 2000 Pflegefachpersonen, davon 658 psychiatrisch Pflegende, nahmen an der deutschlandweit ersten Online-Befragung zum Erleben der beruflichen Situation während des ersten Lockdowns teil. Was sind die Auswirkungen für die Praxis? Die professionelle Behandlung von Patient_innen sowie das Stationsmanagement auf einer psychiatrischen Station während der Corona-Pandemie stellt(e) für die Pflegefachpersonen eine sehr belastende Ausnahmesituation dar.
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- 2022
19. Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
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DUNE Collaboration, Abud, A. Abed, Abi, B., Acciarri, R., Acero, M. A., Adames, M. R., Adamov, G., Adamowski, M., Adams, D., Adinolfi, M., Aduszkiewicz, A., Aguilar, J., Ahmad, Z., Ahmed, J., Aimard, B., Ali-Mohammadzadeh, B., Alion, T., Allison, K., Monsalve, S. Alonso, AlRashed, M., Alt, C., Alton, A., Alvarez, R., Amedo, P., Anderson, J., Andreopoulos, C., Andreotti, M., Andrews, M., Andrianala, F., Andringa, S., Anfimov, N., Ankowski, A., Antoniassi, M., Antonova, M., Antoshkin, A., Antusch, S., Aranda-Fernandez, A., Arellano, L., Arnold, L. O., Arroyave, M. A., Asaadi, J., Asquith, L., Aurisano, A., Aushev, V., Autiero, D., Lara, V. Ayala, Ayala-Torres, M., Azfar, F., Babicz, M., Back, A., Back, H., Back, J. J., Backhouse, C., Bagaturia, I., Bagby, L., Balashov, N., Balasubramanian, S., Baldi, P., Baller, B., Bambah, B., Barao, F., Barenboim, G., Barker, G., Barkhouse, W., Barnes, C., Barr, G., Monarca, J. Barranco, Barros, A., Barros, N., Barrow, J. L., Basharina-Freshville, A., Bashyal, A., Basque, V., Batchelor, C., Chagas, E. Batista das, Battat, J., Battisti, F., Bay, F., Bazetto, M. C. Q., Alba, J. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Beigbeder, C., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Benekos, N., Montiel, C. Benitez, Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Berner, R. M., Bersani, A., Bertolucci, S., Betancourt, M., Rodríguez, A. Betancur, Bevan, A., Bezawada, Y., Bezerra, T. S., Bhardwaj, A., Bhatnagar, V., Bhattacharjee, M., Bhattarai, D., Bhuller, S., Bhuyan, B., Biagi, S., Bian, J., Biassoni, M., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Blaszczyk, F., Blazey, G., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bomben, L., Bonesini, M., Bongrand, M., Bonilla-Diaz, C., Bonini, F., Booth, A., Boran, F., Bordoni, S., Borkum, A., Bostan, N., Bour, P., Bourgeois, C., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Branca, A., Brandt, A., Bremer, J., Breton, D., Brew, C., Brice, S. J., Brizzolari, C., Bromberg, C., Brooke, J., Bross, A., Brunetti, G., Brunetti, M., Buchanan, N., Budd, H., Butorov, I., Cagnoli, I., Cai, T., Caiulo, D., Calabrese, R., Calafiura, P., Calcutt, J., Calin, M., Calvez, S., Calvo, E., Caminata, A., Campanelli, M., Caratelli, D., Carber, D., Carceller, J., Carini, G., Carlus, B., Carneiro, M. F., Carniti, P., Terrazas, I. Caro, Carranza, H., Carroll, T., Forero, J. F. Castaño, Castillo, A., Castromonte, C., Catano-Mur, E., Cattadori, C., Cavalier, F., Cavallaro, G., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. Cervera, Chalifour, M., Chappell, A., Chardonnet, E., Charitonidis, N., Chatterjee, A., Chattopadhyay, S., Neyra, M. Chavarry, Chen, H., Chen, M., Chen, Y., Chen, Z., Chen-Wishart, Z., Cheon, Y., Cherdack, D., Chi, C., Childress, S., Chirco, R., Chiriacescu, A., Chisnall, G., Cho, K., Choate, S., Chokheli, D., Chong, P. S., Christensen, A., Christian, D., Christodoulou, G., Chukanov, A., Chung, M., Church, E., Cicero, V., Clarke, P., Cline, G., Coan, T. E., Cocco, A. G., Coelho, J., Colton, N., Conley, E., Conley, R., Conrad, J., Convery, M., Copello, S., Cova, P., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Crisler, M., Cristaldo, E., Crnkovic, J., Cross, R., Cudd, A., Cuesta, C., Cui, Y., Cussans, D., Dalager, O., Da Motta, H., Peres, L. Da Silva, David, C., David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., De, S., Debbins, P., De Bonis, I., Decowski, M., De Gouvea, A., De Holanda, P. C., Astiz, I. L. De Icaza, Deisting, A., De Jong, P., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., Delmonte, N., De Lurgio, P., Neto, J. R. De Mello, DeMuth, D. M., Dennis, S., Densham, C., Deptuch, G. W., De Roeck, A., De Romeri, V., De Souza, G., Devi, R., Dharmapalan, R., Dias, M., Diaz, F., Diaz, J., Di Domizio, S., Di Giulio, L., Ding, P., Di Noto, L., Dirkx, G., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Doering, D., Dolan, S., Dolek, F., Dolinski, M., Domine, L., Donon, Y., Douglas, D., Douillet, D., Dragone, A., Drake, G., Drielsma, F., Duarte, L., Duchesneau, D., Duffy, K., Dunne, P., Dutta, B., Duyang, H., Dvornikov, O., Dwyer, D., Dyshkant, A., Eads, M., Earle, A., Edmunds, D., Eisch, J., Emberger, L., Emery, S., Englezos, P., Ereditato, A., Erjavec, T., Escobar, C., Eurin, G., Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, K., Falcone, A., Fani', M., Farnese, C., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Menendez, P. Fernandez, Morales, M. Fernandez, Ferraro, F., Fields, L., Filip, P., Filthaut, F., Fiorini, M., Fischer, V., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fogarty, S., Foreman, W., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Robayo, F. Fuentes, Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gabrielli, A., Gago, A., Gallagher, H., Gallas, A., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Gandrajula, R., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardiner, S., Gastler, D., Gauvreau, J., Ge, G., Geffroy, N., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Giammaria, P., Giammaria, T., Giangiacomi, N., Gibin, D., Gil-Botella, I., Gilligan, S., Girerd, C., Giri, A., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Gran, R., Granados, E., Granger, P., Grant, A., Grant, C., Gratieri, D., Green, P., Greenler, L., Greer, J., Grenard, J., Griffith, C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guardincerri, E., Guarino, V., Guarise, M., Guenette, R., Guerard, E., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Gupta, A., Gupta, V., Guthikonda, K., Gutierrez, R., Guzowski, P., Guzzo, M. 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M., Jain, V., James, E., Jang, W., Jargowsky, B., Jediny, F., Jena, D., Jeong, Y., Jesús-Valls, C., Ji, X., Jiang, L., Jiménez, S., Jipa, A., Johnson, R., Johnson, W., Johnston, N., Jones, B., Jones, S., Judah, M., Jung, C., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kakorin, I., Kalitkina, A., Kalra, D., Kamiya, F., Kaneshige, N., Kaplan, D. M., Karagiorgi, G., Karaman, G., Karcher, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Kemularia, O., Ketchum, W., Kettell, S. H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Klustova, A., Kobilarcik, T., Koehler, K., Koerner, L. W., Koh, D. H., Kohn, S., Koller, P. P., Kolupaeva, L., Korablev, D., Kordosky, M., Kosc, T., Kose, U., Kostelecky, V., Kothekar, K., Kralik, R., Kreczko, L., Krennrich, F., Kreslo, I., Kropp, W., Kroupova, T., Kubota, S., Kudenko, Y., Kudryavtsev, V. A., Kulagin, S., Kumar, J., Kumar, P., Kunze, P., Kurita, N., Kuruppu, C., Kus, V., Kutter, T., Kvasnicka, J., Kwak, D., Lambert, A., Land, B., Lane, C. E., Lang, K., Langford, T., Langstaff, M., Larkin, J., Lasorak, P., Last, D., Laundrie, A., Laurenti, G., Lawrence, A., Lazanu, I., LaZur, R., Lazzaroni, M., Le, T., Leardini, S., Learned, J., LeBrun, P., LeCompte, T., Lee, C., Lee, S., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. Leigui, Leitner, M., Lepin, L. M., Li, S., Li, Y., Liao, H., Lin, C., Lin, Q., Lin, S., Lineros, R. A., Ling, J., Lister, A., Littlejohn, B. R., Liu, J., Liu, Y., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Lord, T., LoSecco, J., Louis, W. C., Lu, X., Luk, K., Lunday, B., Luo, X., Luppi, E., Lux, T., Luzio, V. P., Maalmi, J., MacFarlane, D., Machado, A., Machado, P., Macias, C., Macier, J., Maddalena, A., Madera, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Major, A., Maloney, J. A., Mandrioli, G., Mandujano, R. C., Maneira, J. C., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Manyam, V. N., Manzanillas, L., Marchan, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marie, R., Marinho, F., Marino, A. D., Marsden, D., Marshak, M., Marshall, C., Marshall, J., Marteau, J., Martin-Albo, J., Martinez, N., Caicedo, D. A. Martinez, Miravé, P. Martínez, Martynenko, S., Mascagna, V., Mason, K., Mastbaum, A., Matichard, F., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mawby, I., Mazza, R., Mazzacane, A., Mazzucato, E., McAskill, T., McCluskey, E., McConkey, N., McFarland, K. S., McGrew, C., McNab, A., Mefodiev, A., Mehta, P., Melas, P., Mena, O., Mendez, H., Mendez, P., Méndez, D. P., Menegolli, A., Meng, G., Messier, M., Metcalf, W., Mettler, T., Mewes, M., Meyer, H., Miao, T., Michna, G., Miedema, T., Mikola, V., Milincic, R., Miller, G., Miller, W., Mills, J., Mineev, O., Minotti, A., Miranda, O. G., Miryala, S., Mishra, C., Mishra, S., Mislivec, A., Mitchell, M., Mladenov, D., Mocioiu, I., Moffat, K., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J. A., Bueno, L. Molina, Montagna, E., Montanari, A., Montanari, C., Montanari, D., Zetina, L. M. Montano, Moon, S., Mooney, M., Moor, A. F., Moreno, D., Moretti, D., Morris, C., Mossey, C., Mote, M., Motuk, E., Moura, C. A., Mousseau, J., Mouster, G., Mu, W., Mualem, L., Mueller, J., Muether, M., Mufson, S., Muheim, F., Muir, A., Mulhearn, M., Munford, D., Muramatsu, H., Murphy, S., Musser, J., Nachtman, J., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Nath, A., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Negishi, K., Nelson, J. K., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newton, H., Nichol, R., Nicolas-Arnaldos, F., Nikolica, A., Niner, E., Nishimura, K., Norman, A., Norrick, A., Northrop, R., Novella, P., Nowak, J. A., Oberling, M., Ochoa-Ricoux, J., Olivier, A., Olshevskiy, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Palacio, G., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Vazquez, W. Panduro, Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Parke, S., Parozzi, E., Parsa, Z., Parvu, M., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J., Perez, A. Pena, Pennacchio, E., Penzo, A., Peres, O. L., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Pia, V., Piastra, F., Pickering, L., Pietropaolo, F., Pimentel, V. L., Pinaroli, G., Plows, K., Plunkett, R., Poling, R., Pompa, F., Pons, X., Poonthottathil, N., Poppi, F., Pordes, S., Porter, J., Potekhin, M., Potenza, R., Potukuchi, B. V., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prest, M., Prince, S., Psihas, F., Pugnere, D., Qian, X., Raaf, J., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotonandrasana, A., Rakotondravohitra, L., Rameika, R., Delgado, M. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Raut, S., Razakamiandra, R., Rea, E., Real, J., Rebel, B., Rechenmacher, R., Reggiani-Guzzo, M., Reichenbacher, J., Reitzner, S. D., Sfar, H. Rejeb, Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Ribas, M., Riboldi, S., Riccio, C., Riccobene, G., Rice, L. C., Ricol, J., Rigamonti, A., Rigaut, Y., Rincón, E. V., Ritchie-Yates, H., Rivera, D., Robert, A., Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. Rodriguez, Bonilla, E. Rodriguez, Rondon, J. Rodriguez, Rosauro-Alcaraz, S., Rosenberg, M., Rosier, P., Roskovec, B., Rossella, M., Rossi, M., Rout, J., Roy, P., Rubbia, A., Rubbia, C., Russell, B., Ruterbories, D., Rybnikov, A., Saa-Hernandez, A., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Samios, N., Samoylov, O., Sanchez, M., Sandberg, V., Sanders, D. A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schefke, T., Schellman, H., Schifano, S., Schlabach, P., Schmitz, D., Schneider, A. W., Scholberg, K., Schukraft, A., Segreto, E., Selyunin, A., Senise Jr., C. R., Sensenig, J., Sergi, A., Sgalaberna, D., Shaevitz, M., Shafaq, S., Shaker, F., Shamma, M., Sharankova, R., Sharma, H. R., Sharma, R., Sharma, R. K., Shaw, T., Shchablo, K., Shepherd-Themistocleous, C., Sheshukov, A., Shin, S., Shoemaker, I., Shooltz, D., Shrock, R., Siegel, H., Simard, L., Sinclair, J., Sinev, G., Singh, J., Singh, L., Singh, P., Singh, V., Sipos, R., Sippach, F., Sirri, G., Sitraka, A., Siyeon, K., Skarpaas, K., Smith, A., Smith, E., Smith, P., Smolik, J., Smy, M., Snider, E., Snopok, P., Snowden-Ifft, D., Nunes, M. Soares, Sobel, H., Soderberg, M., Sokolov, S., Salinas, C. J. Solano, Söldner-Rembold, S., Soleti, S., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Sotnikov, A., Soto-Oton, J., Ugaldi, F. Soto, Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J. C., Spurgeon, K., Stancari, M., Stanco, L., Stanford, C., Stefan, D., Stein, R., Steiner, H., Lisbôa, A. F. Steklain, Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Strigari, L., Stuart, A., Suarez, J. G., Sunción, J. Suárez, Sulej, R., Sullivan, H., Summers, D., Surdo, A., Susic, V., Suter, L., Sutera, C., Svoboda, R., Szczerbinska, B., Szelc, A. M., Tanaka, H., Tang, S., Tapia, A., Oregui, B. Tapia, Tapper, A., Tariq, S., Tarpara, E., Tata, N., Tatar, E., Tayloe, R., Teklu, A., Tennessen, P., Tenti, M., Terao, K., Ternes, C. A., Terranova, F., Testera, G., Thakore, T., Thea, A., Thompson, J. L., Thorn, C., Timm, S., Tishchenko, V., Tomassetti, L., Tonazzo, A., Torbunov, D., Torti, M., Tortola, M., Tortorici, F., Tosi, N., Totani, D., Toups, M., Touramanis, C., Travaglini, R., Trevor, J., Trilov, S., Trzaska, W. H., Tsai, Y., Tsamalaidze, Z., Tsang, K., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uboldi, L., Uchida, M. A., Urheim, J., Usher, T., Uzunyan, S., Vagins, M. R., Vahle, P., Valder, S., Valdiviesso, G. A., Valencia, E., Valentim, R., Vallari, Z., Vallazza, E., Valle, J. W., Vallecorsa, S., Van Berg, R., Van de Water, R. G., Forero, D. 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J., Wisniewski, W., Wolcott, J., Wongjirad, T., Wood, A., Wood, K., Worcester, E., Worcester, M., Wresilo, K., Wret, C., Wu, W., Xiao, Y., Xie, F., Yaeggy, B., Yandel, E., Yang, G., Yang, K., Yang, T., Yankelevich, A., Yershov, N., Yonehara, K., Yoon, Y., Young, T., Yu, B., Yu, H., Yu, J., Yu, Y., Yuan, W., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhang, Y., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., Zwaska, R., Science and Technology Facilities Council (STFC), Science and Technology Facilities Council, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), DUNE, A. 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C., Fahey, K., Falcone, A., Fani’, M., Farnese, C., Farzan, Y., Fedoseev, D., Felix, J., Feng, Y., Fernandez-Martinez, E., Fernandez Menendez, P., Fernandez Morales, M., Ferraro, F., Fields, L., Filip, P., Filthaut, F., Fiorini, M., Fischer, V., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fogarty, S., Foreman, W., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuentes Robayo, F., Fuess, S., Furic, I. K., Furman, K., Furmanski, A. P., Gabrielli, A., Gago, A., Gallagher, H., Gallas, A., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Ganacim, F., Gandhi, R., Gandrajula, R., Gao, F., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardiner, S., Gastler, D., Gauvreau, J., Ge, G., Geffroy, N., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Giammaria, P., Giammaria, T., Giangiacomi, N., Gibin, D., Gil-Botella, I., Gilligan, S., Girerd, C., Giri, A., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Gomez Bermeo, L., Gomez Fajardo, L. S., Gonnella, F., Gonzalez-Diaz, D., Gonzalez-Lopez, M., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Gran, R., Granados, E., Granger, P., Grant, A., Grant, C., Gratieri, D., Green, P., Greenler, L., Greer, J., Grenard, J., Griffith, C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guardincerri, E., Guarino, V., Guarise, M., Guenette, R., Guerard, E., Guerzoni, M., Guffanti, D., Guglielmi, A., Guo, B., Gupta, A., Gupta, V., Guthikonda, K., Gutierrez, R., Guzowski, P., Guzzo, M. M., Gwon, S., Ha, C., Haaf, K., Habig, A., Hadavand, H., Haenni, R., Hahn, A., Haiston, J., Hamacher-Baumann, P., Hamernik, T., Hamilton, P., Han, J., Harris, D. A., Hartnell, J., Hartnett, T., Harton, J., Hasegawa, T., Hasnip, C., Hatcher, R., Hatfield, K. W., Hatzikoutelis, A., Hayes, C., Hayrapetyan, K., Hays, J., Hazen, E., He, M., Heavey, A., Heeger, K. M., Heise, J., Henry, S., Hernandez Morquecho, M., Herner, K., Hewes, J., Hilgenberg, C., Hill, T., Hillier, S. J., Himmel, A., Hinkle, E., Hirsch, L. R., Ho, J., Hoff, J., Holin, A., Hoppe, E., Horton-Smith, G. A., Hostert, M., Hourlier, A., Howard, B., Howell, R., Hoyos, J., Hristova, I., Hronek, M. S., Huang, J., Hulcher, Z., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ingratta, G., Ioannisian, A., Irwin, B., Isenhower, L., Itay, R., Jackson, C. M., Jain, V., James, E., Jang, W., Jargowsky, B., Jediny, F., Jena, D., Jeong, Y., Jesús-Valls, C., Ji, X., Jiang, L., Jiménez, S., Jipa, A., Johnson, R., Johnson, W., Johnston, N., Jones, B., Jones, S., Judah, M., Jung, C., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kakorin, I., Kalitkina, A., Kalra, D., Kamiya, F., Kaneshige, N., Kaplan, D. M., Karagiorgi, G., Karaman, G., Karcher, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Kemularia, O., Ketchum, W., Kettell, S. H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Klustova, A., Kobilarcik, T., Koehler, K., Koerner, L. W., Koh, D. H., Kohn, S., Koller, P. P., Kolupaeva, L., Korablev, D., Kordosky, M., Kosc, T., Kose, U., Kostelecky, V., Kothekar, K., Kralik, R., Kreczko, L., Krennrich, F., Kreslo, I., Kropp, W., Kroupova, T., Kubota, S., Kudenko, Y., Kudryavtsev, V. A., Kulagin, S., Kumar, J., Kumar, P., Kunze, P., Kurita, N., Kuruppu, C., Kus, V., Kutter, T., Kvasnicka, J., Kwak, D., Lambert, A., Land, B., Lane, C. E., Lang, K., Langford, T., Langstaff, M., Larkin, J., Lasorak, P., Last, D., Laundrie, A., Laurenti, G., Lawrence, A., Lazanu, I., Lazur, R., Lazzaroni, M., Le, T., Leardini, S., Learned, J., Lebrun, P., Lecompte, T., Lee, C., Lee, S., Lehmann Miotto, G., Lehnert, R., Leigui de Oliveira, M., Leitner, M., Lepin, L. M., Li, S., Li, Y., Liao, H., Lin, C., Lin, Q., Lin, S., Lineros, R. A., Ling, J., Lister, A., Littlejohn, B. R., Liu, J., Liu, Y., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Lord, T., Losecco, J., Louis, W. C., Lu, X., Luk, K., Lunday, B., Luo, X., Luppi, E., Lux, T., Luzio, V. P., Maalmi, J., Macfarlane, D., Machado, A., Machado, P., Macias, C., Macier, J., Maddalena, A., Madera, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Major, A., Maloney, J. A., Mandrioli, G., Mandujano, R. C., Maneira, J. C., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Manrique Plata, M., Manyam, V. N., Manzanillas, L., Marchan, M., Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marie, R., Marinho, F., Marino, A. D., Marsden, D., Marshak, M., Marshall, C., Marshall, J., Marteau, J., Martin-Albo, J., Martinez, N., Martinez Caicedo, D. A., Martínez Miravé, P., Martynenko, S., Mascagna, V., Mason, K., Mastbaum, A., Matichard, F., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mawby, I., Mazza, R., Mazzacane, A., Mazzucato, E., Mcaskill, T., Mccluskey, E., Mcconkey, N., Mcfarland, K. S., Mcgrew, C., Mcnab, A., Mefodiev, A., Mehta, P., Melas, P., Mena, O., Mendez, H., Mendez, P., Méndez, D. P., Menegolli, A., Meng, G., Messier, M., Metcalf, W., Mettler, T., Mewes, M., Meyer, H., Miao, T., Michna, G., Miedema, T., Mikola, V., Milincic, R., Miller, G., Miller, W., Mills, J., Mineev, O., Minotti, A., Miranda, O. G., Miryala, S., Mishra, C., Mishra, S., Mislivec, A., Mitchell, M., Mladenov, D., Mocioiu, I., Moffat, K., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J. A., Molina Bueno, L., Montagna, E., Montanari, A., Montanari, C., Montanari, D., Montano Zetina, L. M., Moon, S., Mooney, M., Moor, A. F., Moreno, D., Moretti, D., Morris, C., Mossey, C., Mote, M., Motuk, E., Moura, C. A., Mousseau, J., Mouster, G., Mu, W., Mualem, L., Mueller, J., Muether, M., Mufson, S., Muheim, F., Muir, A., Mulhearn, M., Munford, D., Muramatsu, H., Murphy, S., Musser, J., Nachtman, J., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Nath, A., Navrer-Agasson, A., Nayak, N., Nebot-Guinot, M., Negishi, K., Nelson, J. K., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newton, H., Nichol, R., Nicolas-Arnaldos, F., Nikolica, A., Niner, E., Nishimura, K., Norman, A., Norrick, A., Northrop, R., Novella, P., Nowak, J. A., Oberling, M., Ochoa-Ricoux, J., Olivier, A., Olshevskiy, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Palacio, G., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Panduro Vazquez, W., Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Parke, S., Parozzi, E., Parsa, Z., Parvu, M., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J., Pena Perez, A., Pennacchio, E., Penzo, A., Peres, O. L., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Pia, V., Piastra, F., Pickering, L., Pietropaolo, F., Pimentel, V. L., Pinaroli, G., Plows, K., Plunkett, R., Poling, R., Pompa, F., Pons, X., Poonthottathil, N., Poppi, F., Pordes, S., Porter, J., Potekhin, M., Potenza, R., Potukuchi, B. V., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prest, M., Prince, S., Psihas, F., Pugnere, D., Qian, X., Raaf, J., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotonandrasana, A., Rakotondravohitra, L., Rameika, R., Ramirez Delgado, M., Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Raut, S., Razakamiandra, R., Rea, E., Real, J., Rebel, B., Rechenmacher, R., Reggiani-Guzzo, M., Reichenbacher, J., Reitzner, S. D., Rejeb Sfar, H., Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Ribas, M., Riboldi, S., Riccio, C., Riccobene, G., Rice, L. C., Ricol, J., Rigamonti, A., Rigaut, Y., Rincón, E. V., Ritchie-Yates, H., Rivera, D., Robert, A., Rochester, L., Roda, M., Rodrigues, P., Rodriguez Alonso, M. J., Rodriguez Bonilla, E., Rodriguez Rondon, J., Rosauro-Alcaraz, S., Rosenberg, M., Rosier, P., Roskovec, B., Rossella, M., Rossi, M., Rout, J., Roy, P., Rubbia, A., Rubbia, C., Russell, B., Ruterbories, D., Rybnikov, A., Saa-Hernandez, A., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Samios, N., Samoylov, O., Sanchez, M., Sandberg, V., Sanders, D. A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schefke, T., Schellman, H., Schifano, S., Schlabach, P., Schmitz, D., Schneider, A. W., Scholberg, K., Schukraft, A., Segreto, E., Selyunin, A., Senise, C. R., Sensenig, J., Sergi, A., Sgalaberna, D., Shaevitz, M., Shafaq, S., Shaker, F., Shamma, M., Sharankova, R., Sharma, H. R., Sharma, R., Sharma, R. K., Shaw, T., Shchablo, K., Shepherd-Themistocleous, C., Sheshukov, A., Shin, S., Shoemaker, I., Shooltz, D., Shrock, R., Siegel, H., Simard, L., Sinclair, J., Sinev, G., Singh, J., Singh, L., Singh, P., Singh, V., Sipos, R., Sippach, F., Sirri, G., Sitraka, A., Siyeon, K., Skarpaas, K., Smith, A., Smith, E., Smith, P., Smolik, J., Smy, M., Snider, E., Snopok, P., Snowden-Ifft, D., Soares Nunes, M., Sobel, H., Soderberg, M., Sokolov, S., Solano Salinas, C. J., Söldner-Rembold, S., Soleti, S., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Sotnikov, A., Soto-Oton, J., Soto Ugaldi, F., Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J. C., Spurgeon, K., Stancari, M., Stanco, L., Stanford, C., Stefan, D., Stein, R., Steiner, H., Steklain Lisbôa, A. F., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Strigari, L., Stuart, A., Suarez, J. G., Suárez Sunción, J., Sulej, R., Sullivan, H., Summers, D., Surdo, A., Susic, V., Suter, L., Sutera, C., Svoboda, R., Szczerbinska, B., Szelc, A. M., Tanaka, H., Tang, S., Tapia, A., Tapia Oregui, B., Tapper, A., Tariq, S., Tarpara, E., Tata, N., Tatar, E., Tayloe, R., Teklu, A., Tennessen, P., Tenti, M., Terao, K., Ternes, C. A., Terranova, F., Testera, G., Thakore, T., Thea, A., Thompson, J. L., Thorn, C., Timm, S., Tishchenko, V., Tomassetti, L., Tonazzo, A., Torbunov, D., Torti, M., Tortola, M., Tortorici, F., Tosi, N., Totani, D., Toups, M., Touramanis, C., Travaglini, R., Trevor, J., Trilov, S., Trzaska, W. H., Tsai, Y., Tsamalaidze, Z., Tsang, K., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uboldi, L., Uchida, M. A., Urheim, J., Usher, T., Uzunyan, S., Vagins, M. R., Vahle, P., Valder, S., Valdiviesso, G. A., Valencia, E., Valentim, R., Vallari, Z., Vallazza, E., Valle, J. W., Vallecorsa, S., Van Berg, R., Van de Water, R. G., Vanegas Forero, D., Vannerom, D., Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasina, S., Vasseur, G., Vaughan, N., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., Vicenzi, M., Vieira de Souza, H., Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wallis, C., Wang, H., Wang, J., Wang, L., Wang, M. H., Wang, X., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Wawrowska, K., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, A., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wisniewski, W., Wolcott, J., Wongjirad, T., Wood, A., Wood, K., Worcester, E., Worcester, M., Wresilo, K., Wret, C., Wu, W., Xiao, Y., Xie, F., Yaeggy, B., Yandel, E., Yang, G., Yang, K., Yang, T., Yankelevich, A., Yershov, N., Yonehara, K., Yoon, Y., Young, T., Yu, B., Yu, H., Yu, J., Yu, Y., Yuan, W., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G., Zennamo, J., Zeug, K., Zhang, C., Zhang, S., Zhang, Y., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.
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data analysis method ,Physics - Instrumentation and Detectors ,Physics and Astronomy (miscellaneous) ,530 Physics ,neural network ,Physics::Instrumentation and Detectors ,FOS: Physical sciences ,Physics, Particles & Fields ,High Energy Physics - Experiment ,cascade: electromagnetic ,High Energy Physics - Experiment (hep-ex) ,neutrino ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,High Energy Physics ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Detectors and Experimental Techniques ,Neutrini, argon liquido ,numerical calculations ,physics.ins-det ,0206 Quantum Physics ,Engineering (miscellaneous) ,Science & Technology ,DUNE ,track data analysis ,hep-ex ,Physics ,Instrumentation and Detectors (physics.ins-det) ,time projection chamber: liquid argon ,Nuclear & Particles Physics ,efficiency ,neutrino detector, liquid argon TPC, particle identification ,Experimental High Energy Physics ,Physical Sciences ,0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics ,High Energy Physics::Experiment ,Particle Physics - Experiment ,performance - Abstract
Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments, and is the technology of choice for the Deep Underground Neutrino Experiment (DUNE). In order to perform high precision measurements of neutrinos in the detector, final state particles need to be effectively identified, and their energy accurately reconstructed. This article proposes an algorithm based on a convolutional neural network to perform the classification of energy deposits and reconstructed particles as track-like or arising from electromagnetic cascades. Results from testing the algorithm on experimental data from ProtoDUNE-SP, a prototype of the DUNE far detector, are presented. The network identifies track- and shower-like particles, as well as Michel electrons, with high efficiency. The performance of the algorithm is consistent between experimental data and simulation., Fermi Research Alliance, LLC (FRA) DE-AC02-07CH11359, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ) Fundacao de Amparo a Pesquisa do Estado do Goias (FAPEG) Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Canada Foundation for Innovation IPP, Canada Natural Sciences and Engineering Research Council of Canada (NSERC), CERN, Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government, ERDF, European Union H2020-EU, European Union MSCA, European Union, Centre National de la Recherche Scientifique (CNRS) French Atomic Energy Commission, Istituto Nazionale di Fisica Nucleare (INFN), Portuguese Foundation for Science and Technology European Commission, National Research Foundation of Korea, CAM, Spain La Caixa Foundation Junta de Andalucia-FEDER, Spain Ministry of Science and Innovation, Spain (MICINN) Spanish Government Xunta de Galicia, SERI, Switzerland Swiss National Science Foundation (SNSF), Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK), Royal Society of London UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC) United States Department of Energy (DOE) National Science Foundation (NSF) National Energy Research Scientific Computing Center (NERSC), a U.S. Department of Energy Office of Science User Facility DE-AC02-05CH11231
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- 2022
20. Lewis acid–base adducts of Al(N(C6F5)2)3 and Ga(N(C6F5)2)3 – structural features and dissociation enthalpies
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Julius F. Kögel, Denis A. Sorokin, Martin Scott, Klaus Harms, Daniel Himmel, Ingo Krossing, and Jörg Sundermeyer
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Inorganic Chemistry - Abstract
Herein we present the molecular structures of six neutral Lewis acid–base adducts of the Lewis superacid Al(N(C6F5)2)3 and its higher homolog Ga(N(C6F5)2)3 with the electron pair donors MeCN, CNtBu, THF and PMe3.
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- 2022
21. Toward low-cost biological and hybrid biological/catalytic conversion of cellulosic biomass to fuels
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Lee R. Lynd, Gregg T. Beckham, Adam M. Guss, Lahiru N. Jayakody, Eric M. Karp, Costas Maranas, Robert L. McCormick, Daniel Amador-Noguez, Yannick J. Bomble, Brian H. Davison, Charles Foster, Michael E. Himmel, Evert K. Holwerda, Mark S. Laser, Chiam Yu Ng, Daniel G. Olson, Yuriy Román-Leshkov, Cong T. Trinh, Gerald A. Tuskan, Vikas Upadhayay, Derek R. Vardon, Lin Wang, and Charles E. Wyman
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Nuclear Energy and Engineering ,Renewable Energy, Sustainability and the Environment ,Environmental Chemistry ,Pollution - Abstract
Hybrid processes, featuring biological conversion of lignocellulose to small molecules followed by chemo-catalytic conversion to larger molecules suitable for difficult-to-electrify transport modes, are a promising route to biomass-derived fuels in demand for climate stabilization.
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- 2022
22. Cationic Symmetrically and Unsymmetrically Substituted Diboranes and Bis(diboranes) with Direct Boron‐Boron Bond: Synthesis by Substitution, Stability and Properties
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Lucas Kistner, Erik Filbeck, Patrick Ihle, David Bučak Gasser, Sebastian W. H. Häussermann, Dario Kowatsch, Elisabeth Kaifer, and Hans‐Jörg Himmel
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Organic Chemistry ,Physical and Theoretical Chemistry - Published
- 2023
23. Pyridine Dimers and Their Low‐Temperature Isomerization: A High‐Resolution Matrix‐Isolation Spectroscopy Study
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Olaf Hübner, Jean Thusek, and Hans‐Jörg Himmel
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General Medicine ,General Chemistry ,Catalysis - Published
- 2023
24. Author response: Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins
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Nathaniel J Himmel and Richard Benton
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- 2023
25. Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila
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Nathaniel J Himmel, Akira Sakurai, Atit A Patel, Shatabdi Bhattacharjee, Jamin M Letcher, Maggie N Benson, Thomas R Gray, Gennady S Cymbalyuk, and Daniel N Cox
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General Immunology and Microbiology ,General Neuroscience ,General Medicine ,General Biochemistry, Genetics and Molecular Biology - Abstract
Individual sensory neurons can be tuned to many stimuli, each driving unique, stimulus-relevant behaviors, and the ability of multimodal nociceptor neurons to discriminate between potentially harmful and innocuous stimuli is broadly important for organismal survival. Moreover, disruptions in the capacity to differentiate between noxious and innocuous stimuli can result in neuropathic pain. Drosophila larval class III (CIII) neurons are peripheral noxious cold nociceptors and innocuous touch mechanosensors; high levels of activation drive cold-evoked contraction (CT) behavior, while low levels of activation result in a suite of touch-associated behaviors. However, it is unknown what molecular factors underlie CIII multimodality. Here, we show that the TMEM16/anoctamins subdued and white walker (wwk; CG15270) are required for cold-evoked CT, but not for touch-associated behavior, indicating a conserved role for anoctamins in nociception. We also evidence that CIII neurons make use of atypical depolarizing chloride currents to encode cold, and that overexpression of ncc69—a fly homologue of NKCC1—results in phenotypes consistent with neuropathic sensitization, including behavioral sensitization and neuronal hyperexcitability, making Drosophila CIII neurons a candidate system for future studies of the basic mechanisms underlying neuropathic pain.
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- 2023
26. Machine Learning for Process Control of (Bio)Chemical Processes
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Himmel, Andreas, Matschek, Janine, Kok, Rudolph, Morabito, Bruno, Nguyen, Hoang Hai, and Findeisen, Rolf
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Optimization and Control (math.OC) ,FOS: Electrical engineering, electronic engineering, information engineering ,FOS: Mathematics ,Systems and Control (eess.SY) ,Electrical Engineering and Systems Science - Systems and Control ,Mathematics - Optimization and Control - Abstract
The control of manufacturing processes must satisfy high quality and efficiency requirements while meeting safety requirements. A broad spectrum of monitoring and control strategies, such as model- and optimization-based controllers, are utilized to address these issues. Driven by rising demand for flexible yet energy and resource-efficient operations existing approaches are challenged due to high uncertainties and changes. Machine learning algorithms are becoming increasingly important in tackling these challenges, especially due to the growing amount of available data. The ability for automatic adaptation and learning from human operators offer new opportunities to increase efficiency yet provide flexible operation. Combining machine learning algorithms with safe or robust controls offers novel reliable operation methods. This chapter highlights ways to fuse machine learning and control for the safe and improved operation of chemical and biochemical processes. We outline and summarize both - learning models for control and learning the control components. We offer a general overview, including a literature review, to provide a guideline for utilizing machine learning techniques in control structures.
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- 2023
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27. Nach drei Semestern Online-Studium – Die Rückkehr zum Persönlichen
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Wolfgang Himmel
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- 2023
28. Alles hybrid, oder was? Versuch einer Klärung
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Wolfgang Himmel
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- 2023
29. Structural screens identify candidate human homologs of insect chemoreceptors and crypticDrosophilagustatory receptor-like proteins
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Nathaniel John Himmel and Richard Benton
- Abstract
Insect Odorant receptors and Gustatory receptors define a superfamily of seven-transmembrane domain ligand-gated ion channels (termed here 7TMICs), with homologs identified across Animalia except Chordata. Previously, we used sequence-based screening methods to reveal conservation of this family in unicellular eukaryotes and plants (DUF3537 proteins) (Bentonet al., 2020). Here we combine three-dimensional structure-based screening,ab initioprotein folding predictions, phylogenetics and expression analyses to characterize additional candidate homologs with tertiary but little or no primary structural similarity to known 7TMICs, including proteins in disease-causing Trypanosoma. Unexpectedly, we identify structural similarity between 7TMICs and PHTF proteins, a deeply-conserved family of unknown function, whose human orthologs display enriched expression in testis, cerebellum and muscle. We also discover divergent groups of 7TMICs in insects, which we term the Gustatory receptor-like (Grl) proteins. SeveralDrosophila melanogaster Grls display selective expression in subsets of taste neurons, suggesting that they are previously-unrecognized insect chemoreceptors. Although we cannot exclude the possibility of remarkable structural convergence, our findings support the origin of 7TMICs in a eukaryotic common ancestor, counter previous assumptions of complete loss of 7TMICs in Chordata, and highlight the extreme evolvability of this protein fold, which likely underlies its functional diversification in different cellular contexts.
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- 2022
30. A Multi-plex Protein Expression System for Production of Complex Enzyme Formulations in Trichoderma reesei
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Venkataramanan Subramanian, Samuel J Farmer, Kelsey L Heiland, Kyle T Moore, Todd A Vander Wall, Weiman Sun, Yogesh B Chaudhari, Michael E Himmel, and Stephen R Decker
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Bioengineering ,Applied Microbiology and Biotechnology ,Biotechnology - Abstract
Historically, heterologous protein production has been challenging using the hyper-cellulolytic fungus, Trichoderma reesei. T. reesei is known for poor transformation efficiency, low homologous recombination frequency, and marginal screening systems for identification of successful transformants. In this work, we have applied the 2A-peptide multi-gene expression system to co-express four enzymes, which include three cellulases, a cellobiohydrolase (CBH1), an endoglucanase (EG1), and a β-D-glucosidase (BGL1); as well as the enhanced Green Fluorescent Protein, (eGFP), used here as a marker for monitoring expression levels. We designed a new chassis vector, pTrEno-4X-2A for this work. Expression of these cellulase enzymes was confirmed by real-time quantitative reverse transcription PCR and immunoblot analysis. The activity of each of the cellulases was assessed using pNP glycosides and the chromogenic substrate, AZCL-HE-cellulose, which confirmed the functionality of the enzymes. Expression and activity of these enzymes was proportional to the level of eGFP fluorescence, thereby validating the reliability of this screening technique. Although all three cellulase proteins were successfully expressed, their expression levels varied significantly. Specifically, up to an 18-fold difference was observed between the first and the third gene within the 2A-peptide construct, based on protein quantitation. The availability of this new screening tool is expected to greatly impact multi-enzyme applications, such as production of complex commercial enzyme formulations and the study of metabolic pathway enzymes, especially those destined for cell free applications.
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- 2022
31. A Copper(I) Complex with Two Unpaired Electrons, Synthesised by Oxidation of a Copper(II) Complex with Two Redox‐Active Ligands
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Michael Zharnikov, Elisabeth Kaifer, Marco Werr, Hans-Jörg Himmel, Andika Asyuda, and Markus Enders
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Ligand ,Chemistry ,alcohol oxidation ,chemistry.chemical_element ,General Chemistry ,radicals ,Copper Complexes | Hot Paper ,Copper ,Redox ,Catalysis ,Dication ,Azine ,chemistry.chemical_compound ,Electron transfer ,urea azines ,Unpaired electron ,copper ,Polymer chemistry ,Homoleptic ,Research Articles ,Research Article ,redox-induced electron transfer - Abstract
Two homoleptic copper(II) complexes [Cu(L1)2] and [Cu(L2)2] with anionic redox‐active ligands were synthesised, one with urea azine (L1) and the other with thio‐urea azine (L2) ligands. One‐electron oxidation of the complexes initiates an unprecedented redox‐induced electron transfer process, leading to monocationic copper(I) complexes [Cu(L1)2]+ and [Cu(L2)2]+ with two oxidised ligands. While [Cu(L1)2]+ is best described as a CuI complex with two neutral radical ligands that couple antiferromagnetically, [Cu(L2)2]+ is a CuI complex with two clearly different ligand units in the solid state and with a magnetic susceptibility close to a diamagnetic compound. Further one‐electron oxidation of the complex with L1 ligands results in a dication [Cu(L1)2]2+, best described as a CuI complex with a twofold oxidised, monocationic ligand and a neutral radical ligand. The stability in at least three redox states, the accumulation of spin density at the ligands and the facile ligand‐metal electron transfer make these complexes highly attractive for a variety of applications; here the catalytic aerobic oxidation of alcohols to aldehydes is tested., Oxidation‐induced reduction: The oxidation of mononuclear CuII complexes with novel unsymmetric redox‐active urea azine or thio‐urea azine ligands leads to metal reduction and formation of complexes with intriguing electronic structures. The stability in several redox states is the basis for their first application in catalytic aerobic alcohol oxidation.
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- 2021
32. Synthese eines Kupfer(I)‐Komplexes mit zwei ungepaarten Elektronen durch Oxidation eines Kupfer(II)‐Komplexes mit zwei redoxaktiven Liganden
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Marco Werr, Andika Asyuda, Markus Enders, Hans-Jörg Himmel, Michael Zharnikov, and Elisabeth Kaifer
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Chemistry ,General Medicine - Published
- 2021
33. Stadtsoziologie
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Wolfgang Himmel
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Sociology and Political Science ,Social Psychology - Published
- 2021
34. Synthesis of Symmetrically and Unsymmetrically Substituted Cationic Diborane(4) Compounds with Distinct Structural Motifs and Properties
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Erik Filbeck, Lucas Kistner, Daniel Vogler, David Bučak Gasser, Lilliana Flórido Martins, Maximilian Schöner, Elisabeth Kaifer, and Hans‐Jörg Himmel
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Organic Chemistry ,Physical and Theoretical Chemistry - Published
- 2022
35. Harnessing the Potential of Digital Data for Infectious Disease Surveillance in sub-Saharan Africa
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Ahmad, Amena A., Ahmady-Moghaddam, Nima, Becher, Heiko, Belau, Matthias H., Boenecke, Juliane, Brinkel, Johanna, Clemen, Thomas, Dretvić, Daria, Himmel, Mirko, Kreppel, Katharina, Leal Filho, Walter, Lenfers, Ulfia A., May, Jürgen, Mustafa, Ummul-Khair, Nyambo, Devotha, Pacoe, Luba, Pohlmann, Jennifer, Reintjes, Ralf, Sauli, Elingarami, Streit, Wolfgang, and Ströbele, Jonathan
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Outbreak Detection ,Open Data ,Tanzania ,Digital Surveillance - Abstract
Despite efforts by the WHO to support local surveillance strategies in developing countries, there is a lack of robust public health surveillance frameworks. As a result, early infectious disease outbreak detection and response remain a significant challenge for local health systems in low-resource settings such as sub-Saharan African countries. In contrast, the growing digital infrastructure, especially in the mobile phone sector, and the global availability of extensive digital data offer promising solutions to enhance and strengthen epidemiological surveillance. Yet, there is little insight into concepts of utilisation and transfer into local public health practice. Using Tanzania as an example, a novel electronic surveillance and early outbreak alert framework is being developed that links signals on emerging diseases with relevant contextual Open Data for rapid outbreak risk assessment. The concept focuses on haemorrhagic fever diseases, specifically dengue virus disease, which is increasingly spreading in sub-Saharan Africa. A data stack framework forms the core of the system, which augments electronic information on the occurrence of acute haemorrhagic fever syndrome, e.g., collected via mobile phone-based surveillance tools, with openly available socio-ecological context data specific to dengue. Preliminary results on the data and information flow within the surveillance framework are presented and strategies for an automated indicator-based risk assessment for dengue outbreaks will be discussed, supplemented by an agent-based simulation framework to model possible short-term outbreak scenarios. In addition, adequate data inputs, identified through an appraisal of various data sources available for Tanzania, are outlined. The framework could serve as a blueprint for designing locally implementable early warning and decision support systems integrated with existing digital surveillance infrastructure., Corresponding Author: Juliane Boenecke (juliane.boenecke@bnitm.de) Funding: German Federal Ministry of Education and Research (BMBF) / CONNECT Education-Research-Innovation (Grant ID: 01DU20005), {"references":["Kostkova P, et al. Data and Digital Solutions to Support Surveillance Strategies in the Context of the COVID-19 Pandemic. Front Digit Health. 2021. doi: 10.3389/fdgth.2021.707902","Nyaruaba R, et al. Arboviruses in the East African Community partner states: a review of medically important mosquito-borne Arboviruses. Pathog Glob Health. 2019. doi: 10.1080/20477724.2019.1678939","Petzold S, et al. Dengue algorithms integrated into the IMCI guidelines: An updatedassessment in five Southeast-Asian countries. PLoS Negl Trop Dis. 2022. doi: 10.1371/journal.pntd.0010832","Akter R, et al. Joint effects of climate variability and socioecological factors ondengue transmission: epidemiological evidence. Trop Med Int Health. 2017. doi: 10.1111/tmi.12868"]}
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- 2022
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36. Author response: Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila
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Nathaniel J Himmel, Akira Sakurai, Atit A Patel, Shatabdi Bhattacharjee, Jamin M Letcher, Maggie N Benson, Thomas R Gray, Gennady S Cymbalyuk, and Daniel N Cox
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- 2022
37. Multiscale Engineering of Wood for a Sustainable Future
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Qiang Li, Richard Dixon, Peter Ciesielski, Michael Himmel, Breeanna Urbanowicz, Daxian Cao, and Hongli Zhu
- Abstract
Wood has served humanity by providing tools, fuels, and engineering materials since the Paleolithic period. The composite and hierarchical structure of wood, which is a direct embodiment of stored solar energy and sequestered CO2, exhibits versatile utility. Top-down approaches have enabled recent advances in the engineering, functionalization, and conversion of wood and its derivatives. Its inherent hierarchical structure can be modified by physical and 25chemical methods. Moreover, ‘bottom-up’, targeted genetic engineering approaches have facilitated the modification of wood from molecular scale to nano-, micro-, and bulk scales. Herein, the strategies for manipulating the emergent properties of wood at several scales are reviewed to present sustainable solutions for meeting the current and future demands for materials and energy.
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- 2022
38. Harnessing the potential of digital data for infectious disease surveillance in sub-Saharan Africa
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J Boenecke, J Brinkel, M Belau, M Himmel, and J Ströbele
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Public Health, Environmental and Occupational Health - Abstract
Despite efforts by the WHO to support local surveillance strategies in developing countries, there is a lack of robust public health surveillance frameworks. As a result, early infectious disease outbreak detection and response remain a significant challenge for local health systems in low-resource settings such as sub-Saharan African countries. In contrast, the growing digital infrastructure, especially in the mobile phone sector, and the global availability of extensive digital data offer promising solutions to enhance and strengthen epidemiological surveillance. Yet, there is little insight into concepts of utilisation and transfer into local public health practice. Using Tanzania as an example, a novel electronic surveillance and early outbreak alert framework is being developed that links signals on emerging diseases with relevant contextual Open Data for rapid outbreak risk assessment. The concept focuses on haemorrhagic fever diseases, specifically dengue virus disease, which is increasingly spreading in sub-Saharan Africa. A data stack framework forms the core of the system, which augments electronic information on the occurrence of acute haemorrhagic fever syndrome, e.g., collected via mobile phone-based surveillance tools, with openly available socio-ecological context data specific to dengue. Preliminary results on the data and information flow within the surveillance framework are presented and strategies for an automated indicator-based risk assessment for dengue outbreaks will be discussed, supplemented by an agent-based simulation framework to model possible short-term outbreak scenarios. In addition, adequate data inputs, identified through an appraisal of various data sources available for Tanzania, are outlined. The framework could serve as a blueprint for designing locally implementable early warning and decision support systems integrated with existing digital surveillance infrastructure. Key messages • Digital health surveillance and Open Data offer great potential for early outbreak detection and supporting health decisions but require tailored solutions to benefit low-resource settings. • Building on existing digital surveillance infrastructure, the framework may serve as a blueprint for designing an enhanced surveillance and decision support system for infectious disease outbreaks.
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- 2022
39. Estimating the Hot Rod and Wire Displacement in an Eddy-Current Sensor for Cross-Sectional Area Measurement
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Mario Radschun, Annette Elisabeth Jobst, Christoph Clemens, Olfa Kanoun, and Jorg Himmel
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- 2022
40. Frequency Spectroscopy of the Cross-Section Area of Hot Rods to Approximate Rolling Parameters
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Annette Elisabeth Jobst, Mario Radschun, Christoph Clemens, Olfa Kanoun, and Jorg Himmel
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- 2022
41. Modality specific roles for metabotropic GABAergic signaling and calcium induced calcium release mechanisms in regulating cold nociception
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Atit A. Patel, Akira Sakurai, Nathaniel J. Himmel, and Daniel N. Cox
- Subjects
Cellular and Molecular Neuroscience ,Molecular Biology - Abstract
Calcium (Ca2+) plays a pivotal role in modulating neuronal-mediated responses to multimodal sensory stimuli. Recent studies in Drosophila reveal class III (CIII) multidendritic (md) sensory neurons function as multimodal sensors regulating distinct behavioral responses to innocuous mechanical and nociceptive thermal stimuli. Functional analyses indicate that CIII-mediated multimodal behavioral output is dependent upon activation levels with stimulus-evoked Ca2+ displaying relatively low vs. high intracellular levels in response to gentle touch vs. noxious cold, respectively. However, the mechanistic bases underlying modality-specific differential Ca2+ responses in CIII neurons remain incompletely understood. We hypothesized that noxious cold-evoked high intracellular Ca2+ responses in CIII neurons may rely upon Ca2+-induced Ca2+ release (CICR) mechanisms involving transient receptor potential (TRP) channels and/or metabotropic G-protein coupled receptor (GPCR) activation to promote cold nociceptive behaviors. GABAB receptor mutants and CIII-specific knockdown resulted in impaired noxious cold-evoked behaviors. Gαq and Phospholipase C signaling are likewise required for noxious cold sensing. Additionally, ER localized Ca2+ channels including the Ryanodine receptor (RyR) and Inositol trisphosphate receptor (IP3R) are required for cold nociceptive behaviors. GPCR mediated signaling, through GABAB-R2 and IP3R, is not required in CIII neurons for innocuous touch evoked behaviors. However, CICR via RyR is required in CIII neurons for innocuous touch-evoked behaviors. Disruptions in GABAB-R2, IP3R and RyR in CIII neurons leads to significantly lower levels of cold-evoked Ca2+ responses indicating GPCR and CICR signaling mechanisms function in regulating Ca2+ release. CIII neurons exhibit bipartite cold-evoked firing patterns, where CIII neurons burst during rapid temperature change and tonically fire during steady state cold temperatures. GABAB-R2 knockdown in CIII neurons resulted in disorganized firing patterns during cold exposure. Upon ryanodine pharmacological application, CIII neurons exhibit increased bursting activity and with CIII specific RyR knockdown, there is an increase in cold-evoked tonic firing and decrease in bursting. Lastly, our previous studies implicated the TRPP channel Pkd2 in cold nociception, and here, we show that Pkd2 and IP3R genetically interact in regulating cold-evoked behavior. Collectively, these analyses support novel, modality-specific roles for metabotropic GABAergic signaling and CICR mechanisms in regulating intracellular Ca2+ levels and cold-evoked behavioral output from multimodal CIII neurons.
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- 2022
42. Prospects for engineering Ralstonia eutropha and Zymomonas mobilis for the autotrophic production of 2,3-butanediol from CO2 and H2
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Hui Wei, Wei Wang, Yat-Chen Chou, Michael E. Himmel, Xiaowen Chen, Yannick J. Bomble, and Min Zhang
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- 2023
43. The European Physical Journal C
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Abed Abud, Adam, Abi, Babak, Acciarri, Roberto, Acero, Mario, Adames, Marcio, Adamov, George, Adamowski, Mark, Adams, David, Adinolfi, Marco, Aduszkiewicz, Antoni, Aguilar, Jessica, Ahmad, Zubayer, Ahmed, Jhanzeb, Aimard, Benjamin, Ali-Mohammadzadeh, Behnam, Alion, Tyler, Allison, Kyle, Alonso Monsalve, Saul, AlRashed, Munera, Alt, Christoph, Alton, Andrew, Alvarez, Rodrigo, Amedo, Pablo, Anderson, John, Andreopoulos, Costas, Andreotti, Mirco, Andrews, Michael P., Andrianala, Fenompanirina, Andringa, Sofia, Anfimov, Nikolay, Ankowski, Artur, Antoniassi, Marcelo, Antonova, Maria, Antoshkin, Alexander, Antusch, Stefan, Aranda-Fernandez, Alfredo, Arellano, Luciano, Arnold, Lukas, Arroyave, Manuel, Asaadi, Jonathan, Asquith, Lily, Aurisano, Adam, Aushev, Vladimir, Autiero, Dario, Ayala Lara, Victor, Ayala-Torres, Marco Alberto, Azfar, Farrukh, Back, Ashley, Back, Henning, Back, John, Backhouse, Chris, Bagaturia, Iuri, Bagby, Linda, Balashov, Nikita, Balasubramanian, Supraja, Baldi, Pierre, Baller, Bruce, Bambah, Bindu, Barao, Fernando, Barenboim, Gabriela, Barham Alzas, Pablo, Barker, Gary J., Barkhouse, Wayne, Barnes, Christopher, Barr, Giles, Barranco Monarca, Juan, Barros, Adilson, Barros, Nuno, Barrow, Joshua, Basharina-Freshville, Anastasia, Bashyal, Amit, Basque, Vincent, Batchelor, Charlie, Batista das Chagas, Ewerton, Battat, J.B. R., Battisti, Federico, Bay, Fatih, Bazetto, Maria Cecilia, Bazo Alba, José Luis, Beacom, John, Bechetoille, Edouard, Behera, Biswaranjan, Beigbeder, Christophe, Bellantoni, Leo, Bellettini, Giorgio, Bellini, Vincenzo, Beltramello, Olga, Benekos, Nektarios, Benitez Montiel, Carlos, Bento Neves, Francisco, Berger, Joshua, Berkman, Sophie, Bernardini, Paolo, Berner, Roman, Bersani, Andrea, Bertolucci, Sergio, Betancourt, Minerba, Betancur Rodríguez, Amalia, Bevan, Adrian, Bezawada, Yashwanth, Bezerra, T.J. C., Bhardwaj, Akhil, Bhatnagar, Vipin, Bhattacharjee, Maharnab, Bhattarai, Devesh, Bhuller, Shyam, Bhuyan, Bipul, Biagi, Simone, Bian, Jianming, Biassoni, Matteo, Biery, Kurt, Bilki, Burak, Bishai, Mary, Bitadze, Alexander, Blake, Andrew, Blaszczyk, Flor de Maria, Blazey, Gerald C., Blucher, Edward, Boissevain, Jan, Bolognesi, Sara, Bolton, Timothy, Bomben, Luca, Bonesini, Maurizio, Bongrand, Mathieu, Bonilla-Diaz, Cesar, Bonini, Filiberto, Booth, Alexander, Boran, Fatma, Bordoni, Stefania, Borkum, Aran, Bostan, Nilay, Bour, Petr, Bourgeois, Christian, Boyden, Daniel, Bracinik, Juraj, Braga, Davide, Brailsford, Dominic, Branca, Antonio, Brandt, Andrew, Bremer, Johan, Breton, Dominique, Brew, Christopher, Brice, Stephen, Brizzolari, Claudia, Bromberg, Carl, Brooke, Jim, Bross, Alan, Brunetti, Giulia, Brunetti, Maria, Buchanan, Norman, Budd, Howard, Butorov, Ilia, Cagnoli, Irene, Cai, Tejin, Caiulo, Davide, Calabrese, Roberto, Calafiura, Paolo, Calcutt, Jacob, Calin, Marius, Calvez, Steven, Calvo, Enrique, Caminata, Alessio, Campanelli, Mario, Caratelli, David, Carber, Daniel, Carceller, J.C., Carceller, Juan Miguel, Carini, Gabriella, Carlus, Bruno, Carneiro, Mateus, Carniti, Paolo, Caro Terrazas, Ivan, Carranza, Hector, Carroll, Thomas, Castaño Forero, Javier, Castillo, Andrés, Castromonte, Cesar, Catano-Mur, Erika, Cattadori, Carla, Cavalier, Fabien, Cavallaro, Giuseppe, Cavanna, Flavio, Centro, Sandro, Cerati, Giuseppe, Cervelli, Alberto, Cervera Villanueva, Anselmo, Chalifour, Michel, Chappell, Andrew, Chardonnet, Etienne, Charitonidis, Nikolas, Chatterjee, Animesh, Chattopadhyay, Subhasish, Chavarry Neyra, Michael Steve, Chen, Hucheng, Chen, Mu-Chun, Chen, Yifan, Chen, Zheyang, Chen-Wishart, Zachary, Cheon, Yoolim, Cherdack, Daniel, Chi, Cheng-Yi, Childress, Sam, Chirco, Robert, Chiriacescu, Ana, Chisnall, Georgia, Cho, Kihyeon, Choate, Sarah, Chokheli, David, Chong, Pooi, Christensen, Anne, Christian, David, Christodoulou, Georgios, Chukanov, Artem, Chung, Moses, Church, Eric, Cicero, Valentina, Clarke, Peter, Cline, Gordon, Coan, Thomas, Cocco, Alfredo, Coelho, J.A. B., Colton, Nicole, Conley, Erin, Conley, Robert, Conrad, Janet M., Convery, Mark, Copello, Simone, Cova, Paolo, Cremaldi, Lucien, Cremonesi, Linda, Crespo-Anadón, José, Crisler, Michael, Cristaldo, Esteban, Crnkovic, Jason, Cross, Ryan, Cudd, Andrew, Cuesta, Clara, Cui, Yanou, Cussans, David, Dalager, Olivia, da Motta, Helio, da Silva Peres, Leonardo, David, Claire, David, Quentin, Davies, Gavin, Davini, Stefano, Dawson, Jaime, De, Kaushik, De, Shruti, Debbins, Paul, De Bonis, Isabelle, Decowski, M. Patrick, de Gouvea, Andre, de Holanda, Pedro, de Icaza Astiz, Iker, Deisting, Alexander, De Jong, Paul, Delbart, Alain, Delepine, David, Delgado, Maritza, Dell'Acqua, Andrea, Delmonte, Nicola, De Lurgio, Patrick, de Mello Neto, J.R. T., DeMuth, David, Dennis, Steve, Densham, Chris, Deptuch, Grzegorz, De Roeck, Albert, De Romeri, Valentina, de Souza, Greg, Devi, Ritu, Dharmapalan, Ranjan, Dias, Marco, Diaz, Felix, Diaz, Jorge S., Di Domizio, Sergio, Di Giulio, Letizia, Ding, Pengfei, Di Noto, Lea, Dirkx, Glenn, Distefano, Carla, Diurba, Richard, Diwan, Milind, Djurcic, Zelimir, Doering, Dionisio, Dolan, Stephen, Dolek, Furkan, Dolinski, Michelle J., Domine, Laura, Donon, Yann, Douglas, Daniel, Douillet, Denis, Dragone, Angelo, Drake, Gary, Drielsma, Francois, Duarte, Laura Cristina, Duchesneau, Dominique, Duffy, Kirsty, Dunne, Patrick, Dutta, Bhaskar, Duyang, Hongyue, Dvornikov, Olexiy, Dwyer, Daniel A., Dyshkant, Alexandre S., Eads, Michael, Earle, Antony, Edmunds, Daniel, Eisch, Jonathan, Emberger, Lorenz, Emery, Sandrine, Englezos, Panagiotis, Ereditato, Antonio, Erjavec, Tyler, Escobar, Carlos O., Eurin, Guillaume, Evans, Justin, Ewart, Erin, Ezeribe, Anthony, Fahey, Kevin, Falcone, Andrea, Fani', Mattia, Farnese, Christian, Farzan, Yasaman, Fedoseev, Dmitry, Felix, Julian, Feng, Yue, Fernandez-Martinez, Enrique, Fernandez Menendez, Pablo, Fernandez Morales, Miguel, Ferraro, Federico, Fields, Laura, Filip, Peter, Filthaut, Frank, Fiorini, Massimiliano, Fischer, Vincent, Fitzpatrick, Rory, Flanagan, Will, Fleming, Bonnie, Flight, Robert, Fogarty, Sam, Foreman, Will, Fowler, Jack, Fox, Walt, Franc, Jiri, Francis, Kurt, Franco, Domenico, Freeman, John, Freestone, Julian, Fried, Jack, Friedland, Alex, Fuentes Robayo, Freddy, Fuess, Stu, Furic, Ivan, Furman, Krzysztof, Furmanski, Andrew, Gabrielli, Alessandro, Gago, A.M., Gallagher, Hugh, Gallas, Alexandre, Gallego-Ros, Ana, Gallice, Niccolo, Galymov, Vyacheslav, Gamberini, Enrico, Gamble, Trevor, Ganacim, Francisco, Gandhi, Raj, Gandrajula, Reddy, Gao, Fan, Gao, Shanshan, Garcia-Gamez, Diego, García-Peris, Miguel, Gardiner, Steven, Gastler, Dan, Gauvreau, Jean-Luc, Ge, Guanqun, Geffroy, Nicolas, Gelli, Bruno, Gendotti, Adamo, Gent, Stephen, Ghorbani-Moghaddam, Zahra, Giammaria, Paola, Giammaria, Tommaso, Giangiacomi, Nico, Gibin, Daniele, Gil-Botella, Ines, Gilligan, Sean, Girerd, Claude, Giri, Anjan Kumar, Gnani, Dario, Gogota, Olga, Gold, Michael, Gollapinni, Sowjanya, Gollwitzer, Keith, Gomes, Ricardo, Gomez Bermeo, Laura Vanessa, Gomez Fajardo, L.S., Gonnella, Francesco, Gonzalez-Diaz, Diego, Gonzalez-Lopez, Manuel, Goodman, Maury, Goodwin, Owen, Goswami, Srubabati, Gotti, Claudio, Goudzovski, Evgueni, Grace, Carl, Gran, Rik, Granados, Everardo, Granger, Pierre, Grant, Alan, Grant, Christopher, Gratieri, Diego, Green, Patrick, Greenler, Leland, Greer, Joel, Grenard, Jean-Louis, Griffith, Clark, Groh, Micah, Grudzinski, James, Grzelak, Katarzyna, Gu, Wenqiang, Guardincerri, Elena, Guarino, Victor, Guarise, Marco, Guenette, Roxanne, Guerard, Eric, Guerzoni, Marco, Guffanti, Daniele, Guglielmi, Alberto, Guo, Bing, Gupta, Aseem, Gupta, Vikas, Guthikonda, K.K., Gutierrez, Rafael, Guzowski, Pawel, Guzzo, Marcelo, Gwon, Sunwoo, Ha, Chang Hyon, Haaf, Kevin, Habig, Alec, Hadavand, Haleh, Haenni, Roger, Hahn, Alan, Haiston, James, Hamacher-Baumann, Philip, Hamernik, Thomas, Hamilton, Philip, Han, Jiyeon, Harris, Deborah, Hartnell, Jeffrey, Hartnett, Trevor, Harton, John, Hasegawa, Takyua, Hasnip, Ciaran, Hatcher, Robert, Hatfield, Kaleb, Hatzikoutelis, Athanasios, Hayes, Christopher, Hayrapetyan, Karen, Hays, Jonathan, Hazen, Eric, He, Muyuan, Heavey, Anne, Heeger, Karsten, Heise, Jaret, Henry, Sarah, Hernandez Morquecho, Miguel Angel, Herner, Kenneth, Hewes, V., Hewes, Jeremy, Hilgenberg, Christopher, Hill, Tony, Hillier, Stephen, Himmel, Alexander, Hinkle, Elise, Hirsch, Luciana, Ho, Johnny, Hoff, James, Holin, Anna, Hoppe, Eric, Horton-Smith, Glenn, Hostert, Matheus, Hourlier, Adrien, Howard, Bruce, Howell, Ryan, Hoyos, Jaime, Hristova, Ivana, Hronek, Maxine, Huang, Junying, Hulcher, Zachary, Iles, Gregory, Ilic, Nikolina, Iliescu, Antoniu, Illingworth, Robert, Ingratta, Gianfranco, Ioannisian, Ara, Irwin, Burke, Isenhower, Larry, Itay, Ran, Jackson, Christopher, Jain, Vivek, James, Eric, Jang, Wooyoung, Jargowsky, Benjamin, Jediny, Filip, Jena, Deepika, Jeong, Yu Seon, Jesús-Valls, César, Ji, Xiangpan, Jiang, Libo, Jiménez, Sergio, Jipa, Alexandru, Johnson, Randy, Johnson, Walker, Johnston, Nicholas, Jones, Benjamin, Jones, Sebastian, Judah, Matthew, Jung, Chang Kee, Junk, Thomas, Jwa, Yeon-jae, Kabirnezhad, Monireh, Kaboth, Asher, Kadenko, I., Kakorin, Igor, Kalitkina, Anastasia, Kalra, Daisy, Kamiya, Felipe, Kaneshige, Nathaniel, Kaplan, Daniel, Karagiorgi, Georgia, Karaman, Gurkan, Karcher, Armin, Karolak, Mark, Karyotakis, Yannis, Kasai, Seiji, Kasetti, Siva, Kashur, Lane, Kazaryan, Narine, Kearns, Edward, Keener, Paul, Kelly, Kevin, Kemp, Ernesto, Kemularia, Otari, Ketchum, Wes, Kettell, Steve, Khabibullin, Marat, Khotjantsev, Alexei, Khvedelidze, Arsen, Kim, Doojin, King, Bonnie, Kirby, Brian, Kirby, Mike, Klein, Joshua, Klustova, Anezka, Kobilarcik, Thomas, Koehler, Kevin, Koerner, Lisa, Koh, D.H., Kohn, Sam, Koller, Patrick, Kolupaeva, Liudmila, Korablev, Denis, Kordosky, Mike, Kosc, Thomas, Kose, Umut, Kostelecky, V. Alan, Kothekar, Kunal, Kralik, Robert, Kreczko, Luke, Krennrich, Frank, Kreslo, Igor, Kropp, William, Kroupova, Tereza, Kubota, Shion, Kudenko, Yury, Kudryavtsev, Vitaly A., Kulagin, Sergey, Kumar, Jason, Kumar, Praveen, Kunze, Pablo, Kurita, Nadine, Kuruppu, Chatura, Kus, Vaclav, Kutter, Thomas, Kvasnicka, Jiri, Kwak, Donghyun, Lambert, Andrew, Land, Benjamin, Lane, Charles, Lang, Karol, Langford, Thomas, Langstaff, Mark, Larkin, Jacob, Lasorak, Pierre, Last, David, Laundrie, Andy, Laurenti, Giuliano, Lawrence, Andrew, Lazanu, Ionel, LaZur, Ryan, Lazzaroni, Massimo, Le, Trung, Leardini, Sara, Learned, John, LeBrun, Patrice, LeCompte, Thomas, Lee, Claire, Lee, Soo Yeon, Lehmann Miotto, Giovanna, Lehnert, Ralf, de Oliveira, M.A. Leigui, Leitner, Matthaeus, Lepin, Luis, Li, Shirley W., Li, Yichen, Liao, Heng-Ye, Lin, Cheng-Ju Stephen, Lin, Qing, Lin, Shih-Kai, Lineros, Roberto, Ling, Jiajie, Lister, Adam, Littlejohn, Bryce, Liu, Junze, Liu, Yinrui, Lockwitz, Sarah, Loew, Timothy, Lokajicek, Milos, Lomidze, Irakli, Long, Ken, Lord, Tom, LoSecco, John M., Louis, William, Lu, Xianguo, Luk, Kam-Biu, Lunday, Benjamin, Luo, Xiao, Luppi, Eleonora, Lux, Thorsten, Luzio, Vitor, Maalmi, Jihane, MacFarlane, David, Machado, Ana Amelia, Machado, Pedro, Macias, Christopher Thomas, Macier, Jolie R., Maddalena, Antonello, Madera, Alfonso, Madigan, Peter, Magill, Steve, Mahn, Kendall, Maio, Amélia, Major, Adryanna, Maloney, James, Mandrioli, Gianni, Mandujano, Roberto, Maneira, José, Manenti, Laura, Manly, Steve, Mann, Anthony, Manolopoulos, Konstantinos, Manrique Plata, Maria, Manyam, Venkata, Manzanillas, Luis, Marchan, Miquel, Marchionni, Alberto, Marciano, William, Marfatia, Danny, Mariani, Camillo, Maricic, Jelena, Marie, Rodolphe, Marinho, Franciole, Marino, Alysia, Marsden, David, Marshak, Marvin, Marshall, Chris, Marshall, John, Marteau, Jacques, Martin-Albo, Justo, Martinez, Norman, Martinez Caicedo, David, Martínez Miravé, Pablo, Martynenko, Sergey, Mascagna, Valerio, Mason, Katie, Mastbaum, Andrew, Matichard, Fabrice, Matsuno, Shigenobu, Matthews, James, Mauger, Christopher, Mauri, Nicoletta, Mavrokoridis, Konstantinos, Mawby, Isobel, Mazza, Roberto, Mazzacane, Anna, Mazzucato, Edoardo, McAskill, Tracy, McCluskey, Elaine, McConkey, Nicola, McFarland, Kevin, McGrew, Clark, McNab, Andrew, Mefodiev, Alexander, Mehta, Poonam, Melas, Pantelis, Mena, Olga, Mendez, Hector, Mendez, Patricia, Méndez, Diana, Menegolli, A., Meng, Guang, Messier, Mark, Metcalf, William, Mettler, Thomas, Mewes, Matthew, Meyer, Holger, Miao, Ting, Michna, Gregory, Miedema, Thijs, Mikola, Veera, Milincic, Radovan, Miller, Graham, Miller, William, Mills, Joshua, Mineev, Oleg, Minotti, Alessandro, Miranda, Omar, Miryala, Sandeep, Mishra, C. Shekhar, Mishra, Sanjib R., Mislivec, Aaron, Mitchell, Mote, Mladenov, Dimitar, Mocioiu, Irina, Moffat, Kristian, Moggi, Niccolo, Mohanta, Rukmani, Mohayai, Tanaz, Mokhov, Nikolai, Molina, Jorge, Molina Bueno, Laura, Montagna, Elisabetta, Montanari, Alessandro, Montanari, Claudio, Montanari, David, Zetina, L.M. Montañno, Moon, Seok Ho, Mooney, Michael, Moor, Alexandra, Moreno, Deywis, Moretti, Davide, Morris, Casandra, Mossey, Chris, Mitchell Mote, Motuk, Erdem, Moura, Célio, Mousseau, Joel, Mouster, Gwenn, Mu, Wei, Mualem, Leon, Mueller, Justin, Muether, Mathew, Mufson, Stuart, Muheim, Franz, Muir, Alan, Mulhearn, Mike, Munford, Donnie, Muramatsu, Hajime, Murphy, Sebastien, Musser, Jim, Nachtman, Jane, Nagu, Srishti, Nalbandyan, Mikayel, Nandakumar, Raja, Naples, Donna, Narita, Shinya, Nath, Atanu, Navrer-Agasson, Anyssa, Nayak, Nitish, Nebot-Guinot, Miquel, Negishi, Kentaro, Nelson, Jeff, Nesbit, Jake, Nessi, Marzio, Newbold, David, Newcomer, Mitch, Newton, Hannah, Nichol, Ryan, Nicolas-Arnaldos, Francisco, Nikolica, Adrian, Niner, Evan, Nishimura, Kurtis, Norman, Andrew, Norrick, Anne, Northrop, Rich, Novella, Pau, Nowak, Jaroslaw, Oberling, Michael, Ochoa-Ricoux, Juan Pedro, Olivier, Andrew, Olshevskiy, Alexander, Onel, Yasar, Onishchuk, Yuriy, Ott, Jordan, Pagani, Luca, Palacio, Guillermo, Palamara, Ornella, Palestini, Sandro, Paley, Jonathan, Pallavicini, Marco, Palomares, Carmen, Panduro Vazquez, William, Pantic, Emilija, Paolone, Vittorio, Papadimitriou, Vaia, Papaleo, Riccardo, Papanestis, Antonis, Paramesvaran, Sudarshan, Parke, Stephen, Parozzi, Elisabetta, Parsa, Zohreh, Parvu, Mihaela, Pascoli, Silvia, Pasqualini, Laura, Pasternak, Jaroslaw, Pater, Joleen, Patrick, Cheryl, Patrizii, Laura, Patterson, Ryan, Patton, Simon John, Patzak, Thomas, Paudel, Ajib, Paulos, Bob, Paulucci, Laura, Pavlovic, Zarko, Pawloski, Greg, Payne, David, Pec, Viktor, Peeters, S.J. M., Pena Perez, Aldo, Pennacchio, Elisabetta, Penzo, Aldo, Peres, Orlando, Perry, James, Pershey, Daniel, Pessina, Gianluigi, Petrillo, Gianluca, Petta, Catia, Petti, Roberto, Valerio Pia, Piastra, Francesco, Pickering, Luke, Pietropaolo, Francesco, Pimentel, Vinicius, Pinaroli, Giovanni, Plows, Komninos-John, Plunkett, Robert, Poling, Ronald, Pompa, Federica, Pons, Xavier, Poonthottathil, Navaneeth, Poppi, Francesco, Pordes, Stephen, Porter, Joshua, Potekhin, Maxim, Potenza, Renato, Potukuchi, B.V. K.S., Pozimski, Juergen, Pozzato, Michele, Prakash, Suprabh, Prakash, Tarun, Prest, Michela, Prince, Sebastien, Psihas, Fernanda, Pugnere, Denis, Qian, Xin, Raaf, Jennifer L., Radeka, Veljko, Rademacker, Jonas, Radics, Balint, Rafique, Aleena, Raguzin, Eric, Rai, Mousam, Rajaoalisoa, Miriama, Rakhno, Igor, Rakotonandrasana, Andrianjafy Michaël, Rakotondravohitra, Laza, Rameika, Regina, Ramirez Delgado, Manuel Alejandro, Ramson, Bryan, Rappoldi, A., Raselli, G.L., Ratoff, Peter, Raut, Sanil, Razakamiandra, Rado Fanantenana, Rea, Eran, Real, Jean-Sebastien, Rebel, Brian, Rechenmacher, Ronald, Reggiani-Guzzo, Marina, Reichenbacher, Juergen, Reitzner, S.D., Rejeb Sfar, Haifa, Renshaw, Andrew, Rescia, Sergio, Resnati, Filippo, Ribas, Marlos, Riboldi, Stefano, Riccio, Ciro, Riccobene, Giorgio, Rice, L.C. 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Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), DUNE, Apollo - University of Cambridge Repository, Abud, A Abed, Abi, B, Acciarri, R, Acero, M A, Adames, M R, Adamov, G, Adamowski, M, Adams, D, 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Da Silva Peres, L, David, C, David, Q, Davies, G S, Davini, S, Dawson, J, De, K, De, S, Debbins, P, De Bonis, I, Decowski, M P, De Gouvêa, A, De Holanda, P C, De Icaza Astiz, I L, Deisting, A, De Jong, P, Delbart, A, Delepine, D, Delgado, M, Dell'Acqua, A, Delmonte, N, De Lurgio, P, de Mello Neto, J R T, DeMuth, D M, Dennis, S, Densham, C, Deptuch, G W, De Roeck, A, De Romeri, V, De Souza, G, Devi, R, Dharmapalan, R, Dias, M, Diaz, F, Díaz, J S, Domizio, S Di, Giulio, L Di, Ding, P, Noto, L Di, Dirkx, G, Distefano, C, Diurba, R, Diwan, M, Djurcic, Z, Doering, D, Dolan, S, Dolek, F, Dolinski, M, Domine, L, Donon, Y, Douglas, D, Douillet, D, Dragone, A, Drake, G, Drielsma, F, Duarte, L, Duchesneau, D, Duffy, K, Dunne, P, Dutta, B, Duyang, H, Dvornikov, O, Dwyer, D, Dyshkant, A, Eads, M, Earle, A, Edmunds, D, Eisch, J, Emberger, L, Emery, S, Englezos, P, Ereditato, A, Erjavec, T, Escobar, C, Eurin, G, Evans, J J, Ewart, E, Ezeribe, A C, Fahey, K, Falcone, A, Fani', M, Farnese, C, Farzan, Y, Fedoseev, D, Felix, J, Feng, Y, Fernandez-Martinez, E, Menendez, P Fernandez, Morales, M Fernandez, Ferraro, F, Fields, L, Filip, P, Filthaut, F, Fiorini, M, Fischer, V, Fitzpatrick, R S, Flanagan, W, Fleming, B, Flight, R, Fogarty, S, Foreman, W, Fowler, J, Fox, W, Franc, J, Francis, K, Franco, D, Freeman, J, Freestone, J, Fried, J, Friedland, A, Robayo, F Fuente, Fuess, S, Furic, I K, Furman, K, Furmanski, A P, Gabrielli, A, Gago, A, Gallagher, H, Gallas, A, Gallego-Ros, A, Gallice, N, Galymov, V, Gamberini, E, Gamble, T, Ganacim, F, Gandhi, R, Gandrajula, R, Gao, F, Gao, S, Garcia-Gamez, D, García-Peris, M Á, Gardiner, S, Gastler, D, Gauvreau, J, Ge, G, Geffroy, N, Gelli, B, Gendotti, A, Gent, S, Ghorbani-Moghaddam, Z, Giammaria, P, Giammaria, T, Giangiacomi, N, Gibin, D, Gil-Botella, I, Gilligan, S, Girerd, C, Giri, A K, Gnani, D, Gogota, O, Gold, M, Gollapinni, S, Gollwitzer, K, Gomes, R A, Bermeo, L V Gomez, Fajardo, L S Gomez, Gonnella, F, Gonzalez-Diaz, D, Gonzalez-Lopez, M, Goodman, M C, Goodwin, O, Goswami, S, Gotti, C, Goudzovski, E, Grace, C, Gran, R, Granados, E, Granger, P, Grant, A, Grant, C, Gratieri, D, Green, P, Greenler, L, Greer, J, Grenard, J, Griffith, W C, Groh, M, Grudzinski, J, Grzelak, K, Gu, W, Guardincerri, E, Guarino, V, Guarise, M, Guenette, R, Guerard, E, Guerzoni, M, Guffanti, D, Guglielmi, A, Guo, B, Gupta, A, Gupta, V, Guthikonda, K K, Gutierrez, R, Guzowski, P, Guzzo, M M, Gwon, S, Ha, C, Haaf, K, Habig, A, Hadavand, H, Haenni, R, Hahn, A, Haiston, J, Hamacher-Baumann, P, Hamernik, T, Hamilton, P, Han, J, Harris, D A, Hartnell, J, Hartnett, T, Harton, J, Hasegawa, T, Hasnip, C, Hatcher, R, Hatfield, K W, Hatzikoutelis, A, Hayes, C, Hayrapetyan, K, Hays, J, Hazen, E, He, M, Heavey, A, Heeger, K M, Heise, J, Henry, S, Morquecho, M A Hernandez, Herner, K, Hewes, J, Hilgenberg, C, Hill, T, Hillier, S J, Himmel, A, Hinkle, E, Hirsch, L R, Ho, J, Hoff, J, Holin, A, Hoppe, E, Horton-Smith, G A, Hostert, M, Hourlier, A, Howard, B, Howell, R, Hoyos, J, Hristova, I, Hronek, M S, Huang, J, Hulcher, Z, Iles, G, Ilic, N, Iliescu, A M, Illingworth, R, Ingratta, G, Ioannisian, A, Irwin, B, Isenhower, L, Itay, R, Jackson, C M, Jain, V, James, E, Jang, W, Jargowsky, B, Jediny, F, Jena, D, Jeong, Y S, Jesús-Valls, C, Ji, X, Jiang, L, Jiménez, S, Jipa, A, Johnson, R, Johnson, W, Johnston, N, Jones, B, Jones, S, Judah, M, Jung, C K, Junk, T, Jwa, Y, Kabirnezhad, M, Kaboth, A, Kadenko, I, Kakorin, I, Kalitkina, A, Kalra, D, Kamiya, F, Kaneshige, N, Kaplan, D M, Karagiorgi, G, Karaman, G, Karcher, A, Karolak, M, Karyotakis, Y, Kasai, S, Kasetti, S P, Kashur, L, Kazaryan, N, Kearns, E, Keener, P, Kelly, K J, Kemp, E, Kemularia, O, Ketchum, W, Kettell, S H, Khabibullin, M, Khotjantsev, A, Khvedelidze, A, Kim, D, King, B, Kirby, B, Kirby, M, Klein, J, Klustova, A, Kobilarcik, T, Koehler, K, Koerner, L W, Koh, D H, Kohn, S, Koller, P P, Kolupaeva, L, Korablev, D, Kordosky, M, Kosc, T, Kose, U, Kostelecký, V A, Kothekar, K, Kralik, R, Kreczko, L, Krennrich, F, Kreslo, I, Kropp, W, Kroupova, T, Kubota, S, Kudenko, Y, Kudryavtsev, V A, Kulagin, S, Kumar, J, Kumar, P, Kunze, P, Kurita, N, Kuruppu, C, Kus, V, Kutter, T, Kvasnicka, J, Kwak, D, Lambert, A, Land, B, Lane, C E, Lang, K, Langford, T, Langstaff, M, Larkin, J, Lasorak, P, Last, D, Laundrie, A, Laurenti, G, Lawrence, A, Lazanu, I, LaZur, R, Lazzaroni, M, Le, T, Leardini, S, Learned, J, LeBrun, P, LeCompte, T, Lee, C, Lee, S Y, Miotto, G Lehmann, Lehnert, R, de Oliveira, M A Leigui, Leitner, M, Lepin, L M, Li, S W, Li, Y, Liao, H, Lin, C S, Lin, Q, Lin, S, Lineros, R A, Ling, J, Lister, A, Littlejohn, B R, Liu, J, Liu, Y, Lockwitz, S, Loew, T, Lokajicek, M, Lomidze, I, Long, K, Lord, T, LoSecco, J M, Louis, W C, Lu, X-G, Luk, K B, Lunday, B, Luo, X, Luppi, E, Lux, T, Luzio, V P, Maalmi, J, MacFarlane, D, Machado, A A, Machado, P, Macias, C T, Macier, J R, Maddalena, A, Madera, A, Madigan, P, Magill, S, Mahn, K, Maio, A, Major, A, Maloney, J A, Mandrioli, G, Mandujano, R C, Maneira, J, Manenti, L, Manly, S, Mann, A, Manolopoulos, K, Plata, M Manrique, Manyam, V N, Manzanillas, L, Marchan, M, Marchionni, A, Marciano, W, Marfatia, D, Mariani, C, Maricic, J, Marie, R, Marinho, F, Marino, A D, Marsden, D, Marshak, M, Marshall, C, Marshall, J, Marteau, J, Martín-Albo, J, Martinez, N, Caicedo, D A Martinez, Miravé, P Martínez, Martynenko, S, Mascagna, V, Mason, K, Mastbaum, A, Matichard, F, Matsuno, S, Matthews, J, Mauger, C, Mauri, N, Mavrokoridis, K, Mawby, I, Mazza, R, Mazzacane, A, Mazzucato, E, McAskill, T, McCluskey, E, McConkey, N, McFarland, K S, McGrew, C, McNab, A, Mefodiev, A, Mehta, P, Melas, P, Mena, O, Mendez, H, Mendez, P, Méndez, D P, Menegolli, A, Meng, G, Messier, M D, Metcalf, W, Mettler, T, Mewes, M, Meyer, H, Miao, T, Michna, G, Miedema, T, Mikola, V, Milincic, R, Miller, G, Miller, W, Mills, J, Mineev, O, Minotti, A, Miranda, O G, Miryala, S, Mishra, C S, Mishra, S R, Mislivec, A, Mitchell, M, Mladenov, D, Mocioiu, I, Moffat, K, Moggi, N, Mohanta, R, Mohayai, T A, Mokhov, N, Molina, J, Bueno, L Molina, Montagna, E, Montanari, A, Montanari, C, Montanari, D, Zetina, L M Montañno, Moon, S H, Mooney, M, Moor, A F, Moreno, D, Moretti, D, Morris, C, Mossey, C, Mote, M, Motuk, E, Moura, C A, Mousseau, J, Mouster, G, Mu, W, Mualem, L, Mueller, J, Muether, M, Mufson, S, Muheim, F, Muir, A, Mulhearn, M, Munford, D, Muramatsu, H, Murphy, S, Musser, J, Nachtman, J, Nagu, S, Nalbandyan, M, Nandakumar, R, Naples, D, Narita, S, Nath, A, Navrer-Agasson, A, Nayak, N, Nebot-Guinot, M, Negishi, K, Nelson, J K, Nesbit, J, Nessi, M, Newbold, D, Newcomer, M, Newton, H, Nichol, R, Nicolas-Arnaldos, F, Nikolica, A, Niner, E, Nishimura, K, Norman, A, Norrick, A, Northrop, R, Novella, P, Nowak, J A, Oberling, M, Ochoa-Ricoux, J, Olivier, A, Olshevskiy, A, Onel, Y, Onishchuk, Y, Ott, J, Pagani, L, Palacio, G, Palamara, O, Palestini, S, Paley, J M, Pallavicini, M, Palomares, C, Vazquez, W Panduro, Pantic, E, 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Ratoff, P, Raut, S, Razakamiandra, R F, Rea, E M, Real, J S, Rebel, B, Rechenmacher, R, Reggiani-Guzzo, M, Reichenbacher, J, Reitzner, S D, Sfar, H Rejeb, Renshaw, A, Rescia, S, Resnati, F, Ribas, M, Riboldi, S, Riccio, C, Riccobene, G, Rice, L C J, Ricol, J S, Rigamonti, A, Rigaut, Y, Rincón, E V, Ritchie-Yates, H, Rivera, D, Robert, A, Rochester, L, Roda, M, Rodrigues, P, Alonso, M J Rodriguez, Bonilla, E Rodriguez, Rondon, J Rodriguez, Rosauro-Alcaraz, S, Rosenberg, M, Rosier, P, Roskovec, B, Rossella, M, Rossi, M, Rout, J, Roy, P, Rubbia, A, Rubbia, C, Russell, B, Ruterbories, D, Rybnikov, A, Saa-Hernandez, A, Saakyan, R, Sacerdoti, S, Safford, T, Sahu, N, Sakashita, K, Sala, P, Samios, N, Samoylov, O, Sanchez, M C, Sandberg, V, Sanders, D A, Sankey, D, Santana, S, Santos-Maldonado, M, Saoulidou, N, Sapienza, P, Sarasty, C, Sarcevic, I, Savage, G, Savinov, V, Scaramelli, A, Scarff, A, Scarpelli, A, Schefke, T, Schellman, H, Schifano, S, Schlabach, P, Schmitz, D, Schneider, A W, Scholberg, K, Schukraft, A, Segreto, E, Selyunin, A, Senise, C R, Sensenig, J, Sergi, A, Sgalaberna, D, Shaevitz, M H, Shafaq, S, Shaker, F, Shamma, M, Sharankova, R, Sharma, H R, Sharma, R, Sharma, R K, Shaw, T, Shchablo, K, Shepherd-Themistocleous, C, Sheshukov, A, Shin, S, Shoemaker, I, Shooltz, D, Shrock, R, Siegel, H, Simard, L, Sinclair, J, Sinev, G, Singh, J, Singh, L, Singh, P, Singh, V, Sipos, R, Sippach, F W, Sirri, G, Sitraka, A, Siyeon, K, Skarpaas, K, Smith, A, Smith, E, Smith, P, Smolik, J, Smy, M, Snider, E, Snopok, P, Snowden-Ifft, D, Nunes, M Soare, Sobel, H, Soderberg, M, Sokolov, S, Salinas, C J Solano, Söldner-Rembold, S, Soleti, S R, Solomey, N, Solovov, V, Sondheim, W E, Sorel, M, Sotnikov, A, Soto-Oton, J, Ugaldi, F A Soto, Sousa, A, Soustruznik, K, Spagliardi, F, Spanu, M, Spitz, J, Spooner, N J C, Spurgeon, K, Stancari, M, Stanco, L, Stanford, C, Stein, R, Steiner, H M, Lisbôa, A F Steklain, Stewart, J, Stillwell, B, Stock, J, Stocker, F, Stokes, T, Strait, M, Strauss, T, Strigari, L, Stuart, A, Suarez, J G, Sunción, J M Suárez, Sullivan, H, Summers, D, Surdo, A, Susic, V, Suter, L, Sutera, C M, Svoboda, R, Szczerbinska, B, Szelc, A M, Tanaka, H, Tang, S, Tapia, A, Oregui, B Tapia, Tapper, A, Tariq, S, Tarpara, E, Tata, N, Tatar, E, Tayloe, R, Teklu, A M, Tennessen, P, Tenti, M, Terao, K, Ternes, C A, Terranova, F, Testera, G, Thakore, T, Thea, A, Thompson, J L, Thorn, C, Timm, S C, Tishchenko, V, Tomassetti, L, Tonazzo, A, Torbunov, D, Torti, M, Tortola, M, Tortorici, F, Tosi, N, Totani, D, Toups, M, Touramanis, C, Travaglini, R, Trevor, J, Trilov, S, Trzaska, W H, Tsai, Y, Tsai, Y-T, Tsamalaidze, Z, Tsang, K V, Tsverava, N, Tufanli, S, Tull, C, Tyley, E, Tzanov, M, Uboldi, L, Uchida, M A, Urheim, J, Usher, T, Uzunyan, S, Vagins, M R, Vahle, P, Valder, S, Valdiviesso, G D A, Valencia, E, Valentim, R, Vallari, Z, Vallazza, E, Valle, J W F, Vallecorsa, S, Berg, R Van, de Water, R G Van, Forero, D Vanega, Vannerom, D, Varanini, F, Oliva, D Varga, Varner, G, Vasel, J, Vasina, S, Vasseur, G, Vaughan, N, Vaziri, K, Ventura, S, Verdugo, A, Vergani, S, Vermeulen, M A, Verzocchi, M, Vicenzi, M, de Souza, H Vieira, Vignoli, C, Vilela, C, Viren, B, Vrba, T, Wachala, T, Waldron, A V, Wallbank, M, Wallis, C, Wang, H, Wang, J, Wang, L, Wang, M H L S, Wang, X, Wang, Y, Warburton, K, Warner, D, Wascko, M O, Waters, D, Watson, A, Wawrowska, K, Weatherly, P, Weber, A, Weber, M, Wei, H, Weinstein, A, Wenman, D, Wetstein, M, White, A, Whitehead, L H, Whittington, D, Wilking, M J, Wilkinson, A, Wilkinson, C, Williams, Z, Wilson, F, Wilson, R J, Wisniewski, W, Wolcott, J, Wongjirad, T, Wood, A, Wood, K, Worcester, E, Worcester, M, Wresilo, K, Wret, C, Wu, W, Xiao, Y, Xie, F, Yaeggy, B, Yandel, E, Yang, G, Yang, K, Yang, T, Yankelevich, A, Yershov, N, Yonehara, K, Yoon, Y S, Young, T, Yu, B, Yu, H, Yu, J, Yu, Y, Yuan, W, Zaki, R, Zalesak, J, Zambelli, L, Zamorano, B, Zani, A, Zazueta, L, Zeller, G P, Zennamo, J, Zeug, K, Zhang, C, Zhang, S, Zhang, Y, Zhao, M, Zhivun, E, Zhu, G, Zimmerman, E D, Zucchelli, S, Zuklin, J, Zutshi, V, Zwaska, R, Abud, A, Acero, M, Adames, M, Monsalve, S, Alrashed, M, Arnold, L, Arroyave, M, Lara, V, Back, J, Alzas, P, Monarca, J, Barrow, J, Chagas, E, Battat, J, Bazetto, M, Alba, J, Beacom, J, Montiel, C, Neves, F, Berner, R, Rodriguez, A, Bezerra, T, Blazey, G, Brice, S, Carceller, J, Carneiro, M, Terrazas, I, Forero, J, Villanueva, A, Neyra, M, Chong, P, Coan, T, Cocco, A, Coelho, J, Crespo-Anadon, J, Davies, G, Decowski, M, De Gouvea, A, De Holanda, P, De Icaza Astiz, I, de Mello Neto, J, Demuth, D, Deptuch, G, Diaz, J, Domizio, S, Giulio, L, Noto, L, Evans, J, Ezeribe, A, Menendez, P, Morales, M, Fitzpatrick, R, Robayo, F, Furic, I, Furmanski, A, Garcia-Peris, M, Giri, A, Gomes, R, Bermeo, L, Fajardo, L, Goodman, M, Griffith, W, Guthikonda, K, Guzzo, M, Harris, D, Hatfield, K, Heeger, K, Morquecho, M, Hillier, S, Hirsch, L, Horton-Smith, G, Hronek, M, Iliescu, A, Jackson, C, Jeong, Y, Jesus-Valls, C, Jimenez, S, Jung, C, Kaplan, D, Kasetti, S, Kelly, K, Kettell, S, Koerner, L, Koh, D, Koller, P, Kostelecky, V, Kudryavtsev, V, Lane, C, Lazur, R, Lebrun, P, Lecompte, T, Lee, S, Miotto, G, de Oliveira, M, Lepin, L, Li, S, Lin, C, Lineros, R, Littlejohn, B, Losecco, J, Louis, W, Lu, X, Luk, K, Luzio, V, Macfarlane, D, Machado, A, Macias, C, Macier, J, Maloney, J, Mandujano, R, Plata, M, Manyam, V, Marino, A, Martin-Albo, J, Caicedo, D, Mirave, P, Mcaskill, T, Mccluskey, E, Mcconkey, N, Mcfarland, K, Mcgrew, C, Mcnab, A, Mendez, D, Messier, M, Miranda, O, Mishra, C, Mishra, S, Mohayai, T, Bueno, L, Zetina, L, Moon, S, Moor, A, Moura, C, Nelson, J, Nowak, J, Paley, J, Vazquez, W, Patterson, R, Patton, S, Peeters, S, Perez, A, Peres, O, Pimentel, V, Potukuchi, B, Raaf, J, Razakamiandra, R, Rea, E, Real, J, Reitzner, S, Sfar, H, Rice, L, Ricol, J, Rincon, E, Alonso, M, Bonilla, E, Rondon, J, Sanchez, M, Sanders, D, Schneider, A, Senise, C, Shaevitz, M, Sharma, H, Sippach, F, Nunes, M, Salinas, C, Soldner-Rembold, S, Soleti, S, Sondheim, W, Ugaldi, F, Spooner, N, Steiner, H, Lisboa, A, Suarez, J, Suncion, J, Sutera, C, Szelc, A, Oregui, B, Teklu, A, Ternes, C, Thompson, J, Timm, S, Trzaska, W, Tsang, K, Uchida, M, Vagins, M, Valdiviesso, G, Valle, J, Berg, R, de Water, R, Forero, D, Oliva, D, Vermeulen, M, de Souza, H, Waldron, A, Wang, M, Wascko, M, Whitehead, L, Wilking, M, Wilson, R, Yoon, Y, Zeller, G, and Zimmerman, E
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Physics - Instrumentation and Detectors ,Science & Technology ,Physics and Astronomy (miscellaneous) ,Regular Article - Experimental Physics ,Physics::Instrumentation and Detectors ,530 Physics ,Physics ,Settore FIS/01 - Fisica Sperimentale ,FOS: Physical sciences ,neutrino detector, dual phase liquid argon TPC, scintillation light ,Instrumentation and Detectors (physics.ins-det) ,Nuclear & Particles Physics ,Settore FIS/04 - Fisica Nucleare e Subnucleare ,Physics, Particles & Fields ,neutrino ,DUNE Collaboration ,Physical Sciences ,SIMULATION ,0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,High Energy Physics ,Detectors and Experimental Techniques ,Engineering (miscellaneous) ,physics.ins-det ,0206 Quantum Physics - Abstract
Funder: Ministerio de Ciencia e Innovación; doi: http://dx.doi.org/10.13039/501100004837, Funder: Xunta de Galicia; doi: http://dx.doi.org/10.13039/501100010801, Funder: Conselho Nacional de Desenvolvimento Científico e Tecnológico; doi: http://dx.doi.org/10.13039/501100003593, Funder: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; doi: http://dx.doi.org/10.13039/501100004586, Funder: Instituto Nazionale di Fisica Nucleare; doi: http://dx.doi.org/10.13039/501100004007, Funder: Fundação Amazônia Paraense de Amparo à Pesquisa; doi: http://dx.doi.org/10.13039/501100005288, Funder: Junta de Andalucia-FEDER, Funder: Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; doi: http://dx.doi.org/10.13039/501100002790, Funder: “la Caixa” Foundation; doi: http://dx.doi.org/10.13039/100010434, Funder: Canada Foundation for Innovation; doi: http://dx.doi.org/10.13039/501100000196, Funder: UK Research and Innovation; doi: http://dx.doi.org/10.13039/100014013, Funder: Royal Society; doi: http://dx.doi.org/10.13039/501100000288, Funder: IPP, Funder: Centre National de la Recherche Scientifique; doi: http://dx.doi.org/10.13039/501100004794, Funder: CEA, Funder: National Science Foundation; doi: http://dx.doi.org/10.13039/100000001, Funder: Türkiye Bilimsel ve Teknolojik Arastirma Kurumu; doi: http://dx.doi.org/10.13039/501100004410, Funder: MSMT, Funder: CERN; doi: http://dx.doi.org/10.13039/100012470, Funder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; doi: http://dx.doi.org/10.13039/501100001711, Funder: Comunidad de Madrid; doi: http://dx.doi.org/10.13039/100012818, Funder: Fundação de Amparo à Pesquisa do Estado de Goiá s; doi: http://dx.doi.org/10.13039/501100005285, Funder: FCT, Funder: National Research Foundation; doi: http://dx.doi.org/10.13039/501100001321, Funder: U.S. Department of Energy; doi: http://dx.doi.org/10.13039/100000015, Funder: Marie Sklodowska-Curie Actions; doi: http://dx.doi.org/10.13039/100018694, Funder: Science and Technology Facilities Council; doi: http://dx.doi.org/10.13039/501100000271, Funder: European Regional Development Fund; doi: http://dx.doi.org/10.13039/501100008530, DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6 × 6 × 6 m 3 liquid argon time-projection-chamber (LArTPC) that recorded cosmic-muon data at the CERN Neutrino Platform in 2019-2020 as a prototype of the DUNE Far Detector. Charged particles propagating through the LArTPC produce ionization and scintillation light. The scintillation light signal in these detectors can provide the trigger for non-beam events. In addition, it adds precise timing capabilities and improves the calorimetry measurements. In ProtoDUNE-DP, scintillation and electroluminescence light produced by cosmic muons in the LArTPC is collected by photomultiplier tubes placed up to 7 m away from the ionizing track. In this paper, the ProtoDUNE-DP photon detection system performance is evaluated with a particular focus on the different wavelength shifters, such as PEN and TPB, and the use of Xe-doped LAr, considering its future use in giant LArTPCs. The scintillation light production and propagation processes are analyzed and a comparison of simulation to data is performed, improving understanding of the liquid argon properties.
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- 2022
44. Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage
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Fang Yu, Lauren E. Himmel, Karen A. Hasty, Craig L. Duvall, Hongsik Cho, Danielle D. Liu, Leslie J. Crofford, Juan M. Colazo, Meredith A. Jackson, and Sean K. Bedingfield
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Small interfering RNA ,Chemistry ,Angiogenesis ,Cartilage ,Biomedical Engineering ,Type II collagen ,Medicine (miscellaneous) ,Bioengineering ,Inflammation ,Osteoarthritis ,Matrix metalloproteinase ,medicine.disease ,Computer Science Applications ,Cell biology ,Extracellular matrix ,medicine.anatomical_structure ,medicine ,medicine.symptom ,Biotechnology - Abstract
The progression of osteoarthritis is associated with inflammation triggered by the enzymatic degradation of extracellular matrix in injured cartilage. Here we show that a locally injected depot of nanoparticles functionalized with an antibody targeting type II collagen and carrying small interfering RNA targeting the matrix metalloproteinase 13 gene (Mmp13), which breaks down type II collagen, substantially reduced the expression of MMP13 and protected cartilage integrity and overall joint structure in acute and severe mouse models of post-traumatic osteoarthritis. MMP13 inhibition suppressed clusters of genes associated with tissue restructuring, angiogenesis, innate immune responses and proteolysis. We also show that intra-articular injections of the nanoparticles led to greater reductions in disease progression than either a single injection or weekly injections of the steroid methylprednisolone. Sustained drug retention by targeting collagen in the damaged extracellular matrix of osteoarthritic cartilage may also be an effective strategy for the treatment of osteoarthritis with other disease-modifying drugs. An intra-articularly injected depot of nanoparticles targeting collagen and delivering small interfering RNA for matrix metalloproteinase 13 protects cartilage integrity and joint structure in mice with post-traumatic osteoarthritis.
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- 2021
45. The Dioxygen Complexes of VO 2
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Hans-Jörg Himmel and Olaf Hübner
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Inorganic Chemistry ,Chemistry ,Transition metal dioxygen complex ,Matrix isolation ,Infrared spectroscopy ,Vanadium ,chemistry.chemical_element ,Photochemistry - Published
- 2021
46. Proton‐Coupled Electron Transfer (PCET) with 1,4‐Bisguanidino‐Benzene Derivatives: Comparative Study and Use in Acid‐Initiated C‐H Activation
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Petra Walter, Olaf Hübner, Elisabeth Kaifer, and Hans-Jörg Himmel
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proton-coupled electron transfer ,proton affinity ,Hot Paper ,Electrons ,Protonation ,Redox ,C−H activation ,Catalysis ,redox potential ,Electron Transport ,Electron transfer ,chemistry.chemical_compound ,Computational chemistry ,Benzene Derivatives ,Reactivity (chemistry) ,Full Paper ,Organic Chemistry ,Chloranil ,General Chemistry ,Full Papers ,chemistry ,Intramolecular force ,Proton affinity ,Protons ,Proton-coupled electron transfer ,Oxidation-Reduction ,guanidines - Abstract
Proton‐coupled electron transfer (PCET) is of key importance in modern synthetic chemistry. Redox‐active guanidines were established by our group as valuable alternatives to toxic high‐potential benzoquinones in a variety of different PCET reactions. In this work, the PCET reactivity of a series of 1,4‐bisguanidino‐benzenes varying in their redox potentials and proton affinities is evaluated. The relevant redox and protonation states are fully characterized, and the compounds sorted with respect to their PCET reactivity by comparative PCET experiments supplemented by quantum‐chemical calculations. Depending on the studied reactions, the driving force is either electron transfer or proton transfer; thereby the influence of both processes on the overall reactivity could be assessed. Then, two of the PCET reagents are applied in representative oxidative aryl‐aryl coupling reactions, namely the intramolecular coupling of 3,3’’‐4,4’’‐tetramethoxy‐o‐terphenyl to give the corresponding triphenylene, the intermolecular coupling of N‐ethylcarbazole to give N,N’‐diethyl‐3,3’‐bicarbazole, and in the oxidative lactonization of 2‐[(4‐methoxyphenyl)methyl]‐benzoic acid. Under mild conditions, the reactions proceed fast and efficient. Only small amounts of acid are needed, in clear contrast to the corresponding coupling reactions with traditional high‐potential benzoquinones such as DDQ or chloranil requiring a large excess of a strong acid., 1,4‐Bisguanidino‐benzenes are versatile reagents in proton‐coupled electron transfer (PCET) reactions. In this work the effect of guanidino group modification on the PCET reactivity is evaluated (X=H or OMe) and the best performing two compounds applied in intra‐ and inter‐molecular aryl‐aryl coupling and oxidative lactonization test reactions. In difference to related reactions with high‐potential benzoquinones, only a small amount of acid is required to inititiate efficient reactions under mild conditions.
- Published
- 2021
47. Finding Temporal Paths Under Waiting Time Constraints
- Author
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Casteigts, Arnaud, Himmel, Anne-Sophie, Molter, Hendrik, and Zschoche, Philipp
- Subjects
parameterized algorithms ,General Computer Science ,Computer science ,Mathematics of computing → Graph algorithms ,NP-hard problems ,Parameterized complexity ,0102 computer and information sciences ,02 engineering and technology ,01 natural sciences ,restless temporal paths ,Pathwidth ,020204 information systems ,Algorithmics ,0202 electrical engineering, electronic engineering, information engineering ,timed feedback vertex set ,Time complexity ,Discrete mathematics ,Temporal graphs ,Applied Mathematics ,Computer Science Applications ,Vertex (geometry) ,disease spreading ,Constraint (information theory) ,waiting-time policies ,010201 computation theory & mathematics ,Theory of computation ,Path (graph theory) ,020201 artificial intelligence & image processing ,ddc:004 - Abstract
Computing a (short) path between two vertices is one of the most fundamental primitives in graph algorithmics. In recent years, the study of paths in temporal graphs, that is, graphs where the vertex set is fixed but the edge set changes over time, gained more and more attention. A path is time-respecting, or temporal, if it uses edges with non-decreasing time stamps. We investigate a basic constraint for temporal paths, where the time spent at each vertex must not exceed a given duration Δ, referred to as Δ-restless temporal paths. This constraint arises naturally in the modeling of real-world processes like packet routing in communication networks and infection transmission routes of diseases where recovery confers lasting resistance. While finding temporal paths without waiting time restrictions is known to be doable in polynomial time, we show that the "restless variant" of this problem becomes computationally hard even in very restrictive settings. For example, it is W[1]-hard when parameterized by the feedback vertex number or the pathwidth of the underlying graph. The main question thus is whether the problem becomes tractable in some natural settings. We explore several natural parameterizations, presenting FPT algorithms for three kinds of parameters: (1) output-related parameters (here, the maximum length of the path), (2) classical parameters applied to the underlying graph (e.g., feedback edge number), and (3) a new parameter called timed feedback vertex number, which captures finer-grained temporal features of the input temporal graph, and which may be of interest beyond this work., LIPIcs, Vol. 181, 31st International Symposium on Algorithms and Computation (ISAAC 2020), pages 30:1-30:18
- Published
- 2021
48. Mittendrin statt nur dabei
- Author
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Claudia Himmel and Johanna Blöcker
- Subjects
General Materials Science - Published
- 2022
49. Biorisk assessment of genetic engineering — lessons learned from teaching interdisciplinary courses on responsible conduct in the life sciences
- Author
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Mirko Himmel, Anastasia A. Malygina, and Marina S. Dukhinova
- Subjects
Ecology ,Health, Toxicology and Mutagenesis ,Genetics ,Biochemistry ,Agricultural and Biological Sciences (miscellaneous) ,Genetics (clinical) ,Ecology, Evolution, Behavior and Systematics ,Biotechnology - Abstract
Genetic engineering is one of the ground-breaking technologies developed in the 20th century with great prospects for improving human, animal, and plant health, providing food security as well as environmental protection in times of climate change. From the early beginning on, scientists were debating about benefits and risks of genetic engineering and actively proposed measures for safe use of this technology. This led to the concept of biosafety which aims at protecting humans and the environment from unwanted consequences of the use of genetic engineering. Genetic engineering could be misapplied for even enhancing the threat potential of pathogens or toxins. The concept of biosecurity has been introduced to protect biomedicine and the life sciences of being misused for criminal or hostile purposes by malicious actors. The new WHO Guidance framework for the responsible use of the life sciences is the most recent example for improving awareness among partitioners in science to strengthening biorisk assessment strategies [1]. But still, there is the need for implementing any of such proposed biorisk assessment frameworks on national and institutional levels. Ideally, comprehensive training of students in the life sciences in biosafety and biosecurity should be mandatory worldwide and embedded in the curricula of their bachelor and master study programmes [2]. But how to engage students and improve their understanding for cross-disciplinary approaches in strengthening biosafety and biosecurity? Which teaching techniques are appropriate? Is there an opportunity for innovation? [3] The work presented here addresses these questions and provides insights in joint teaching activities of the last two years.
- Published
- 2022
50. Interplay and Competition Between Two Different Types of Redox‐Active Ligands in Cobalt Complexes: How to Allocate the Electrons?
- Author
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Lukas Lohmeyer, Marco Werr, Elisabeth Kaifer, and Hans‐Jörg Himmel
- Subjects
Organic Chemistry ,General Chemistry ,Catalysis - Abstract
The field of molecular transition metal complexes with redox-active ligands is dominated by compounds with one or two units of the same redox-active ligand; complexes in which different redox-active ligands are bound to the same metal are uncommon. This work reports the first molecular coordination compounds in which redox-active bisguanidine or urea azine (biguanidine) ligands as well as oxolene ligands are bound to the same cobalt atom. The combination of two different redox-active ligands leads to mono- as well as unprecedented dinuclear cobalt complexes, being multiple (four or six) center redox systems with intriguing electronic structures, all exhibiting radical ligands. By changing the redox potential of the ligands through derivatisation, the electronic structure of the complexes could be altered in a rational way.
- Published
- 2022
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