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Seismic reflection profiles combined with sediment cores reveal centennial changes in the proximal and distal sedimentation regime in the Rhone River delta system (Lake Geneva) which is dominated by sublacustrine channels. From detailed analyses of the thickness distribution of depositional units and the occurrence of turbidites at least two shifts of the primarily active sublacustrine channels are inferred for the past 1500 years. The first northward shift is dated at 1480 ± 20 cal AD and was likely linked to a centennial flood in the Swiss Rhone Valley that occurred in 1469 AD and acted either as a direct cause or as a preconditioning factor favoring the shifting. A shift back southward in 1720 ± 90 cal AD may have been caused either by long term human impact related to the first embankment constructions on the Rhone River or by a natural event such as the 1755 AD Brig earthquake or the centennial flood of 1640 AD. Another important change in the sedimentation regime occurs in 1775 ± 125 cal AD when the onset of Rhone turbidite deposition is recorded in the distal sediments. This relative “progradation” of the Rhone turbidites is certainly due to the disconnection of the Vieux Rhone branch before 1826 and the subsequent first Rhone River correction starting in 1863 that led to the present single active Rhone subaquatic channel.

A cat was presented with right head tilt and circling. The lack of expression of virus antigens did not support the postmortem diagnosis of encephalomyelitis pointing to a diffuse primary central nervous system T-cell lymphoma on the basis of CD3 and CD45R co-expression with absence of CD79α staining.

In the late 19th century, F.A. FOREL led investigations of the Rhone River delta area of Lake Geneva that resulted in the discovery of a textbook example of a river-fed delta system containing impressive subaquatic channels. Well ahead of the marine counterparts, scientific observations and interpretations of water currents shaping the delta edifice for the first time documented how underflow currents carry cold, suspension-laden waters from the river mouth all the way to the deep basin. These early investigations of the Rhone delta laid the basis for follow-up studies in the 20th and 21th centuries. Sediment coring, water-column measurements, manned submersible diving, seismic reflection profiling and bathymetric surveying eventually provided a rich database to unravel the key erosional and depositional processes, further documenting the impact of human-induced changes in the catchment. With the merging of old and new scientific knowledge, today a comprehensive understanding prevails of how a delta changes through time, how its channels are formed, and what potential natural hazards may be related to its evolution. New and efficient bathymetric techniques, paired with novel coring operations, provided a time-series of morphologic evolution showing and quantifying the high dynamics of the delta/channel evolution in an unprecedented temporal and spatial resolution. Future investigations will continue to further quantify these dynamic processes and to link the evolution of the subaquatic domain with changes and processes in the catchment and with natural hazards. Its size, easy access, and large variety of states and processes will continue to make the Rhone delta area a perfect ‘laboratory' in which general processes can be studied that could be upscaled or downscaled to other marine and lacustrine deltas.

Subaquatic canyons in deltas are major pathways for the transport of particles from rivers / the upper delta slops to the deep basins. They represent active environments with frequent deltaic failures and massmovements potentially bearing hazard-related (tsunami waves) and economic (infrastructure damages) implications. Understanding sedimentary processes and mass-movement triggering mechanisms is crucial to assess related consequences and to carry out geological risk assessments. The Rhone River delta in Lake Geneva (Switzerland, France) is a complex underwater structure with several active and inactive subaquatic canyons, similar to marine deltas but at a smaller scale. The difference between two bathymetric surveys in 1986 and 2002 revealed an inversion in the topography of the distal active canyon, as a former distal canyon was transformed into a mound-like structure. A 12 m-thick layer was deposited in the canyon and modified the sediment transfer conduit. Sediment cores from this deposit were retrieved in-situ in 2002 and 2011 via the “F.-A. Forel” and Russian MIR submersibles, respectively. These cores contained a homogeneous, sandy material. Its sediment texture, grain-size, high density and shear strength, and low water content suggests that it corresponds to a debris-flow deposit that possibly took place after the initiation of a mass movement due to a scarp failure in proximal areas of the canyon. In addition, in situ geotechnical tests on the modern canyon floor have shown a soft top layer above a stiffer substratum. This soft layer, which increases in thickness towards distal areas, may act as a basal surface for hydroplaning, and might have allowed the debrite to be transported 9 km away from the source of the scarp failure. Similarities in textures and grain-size of the debris flow and levee deposits hint at the proximal northern levee as the source of this material. Rapid sediment loading in this area, at the rate of >2.5cm/yr, steep slopes in the canyon walls and increased pore pressure due to high methane concentrations may have reduced the stability of the canyon wall in this area. Discrete sandy intervals show very high methane concentrations and thus could correspond to potentially weak layers prone to scarp failures. Nevertheless, the probable cause for the 2000 AD Rhone delta event was an exceptional flood in October 2000 which undercut the slope, and subsequently decreased the stability by increasing the shear stress and triggered the mass failure in the already unstable canyon walls. Besides economic and hazard-related implications, such mass failures represent significant and underestimated causes in morphological evolution of underwater canyons by damming the channel and, eventually, forming short-term meanders susceptible to further erosion, as seen in a recent multibeam bathymetric map obtained in 2012.

Bovine herpesvirus 1 (BoHV-1) and BoHV-5 are closely related pathogens of cattle, but only BoHV-5 is considered a neuropathogen. We engineered intertypic gD exchange mutants with BoHV-1 and BoHV-5 backbones in order to address their in vitro and in vivo host ranges, with particular interest in invasion of the brain. The new viruses replicated in cell culture with similar dynamics and to titers comparable to those of their wild-type parents. However, gD of BoHV-5 (gD5) was able to interact with a surprisingly broad range of nectins. In vivo , gD5 provided a virulent phenotype to BoHV-1 in AR129 mice, featuring a high incidence of neurological symptoms and early onset of disease. However, only virus with the BoHV-5 backbone, independent of the gD type, was detected in the brain by immunohistology. Thus, gD of BoHV-5 confers an extended cellular host range to BoHV-1 and may be considered a virulence factor but does not contribute to the invasion of the brain.

In Switzerland, dicrocoeliasis is regarded as the most significant parasitic infection of llamas and alpacas. Fasciola hepatica infestation is also a problem but less common. The aim of the present retrospective study was to evaluate the lungs of New World camelids (NWCs) for evidence of arterial hypertension in association with liver changes due to liver fluke infestation. The lungs of 20 llamas and 20 alpacas with liver fluke infestation were histologically evaluated. The hematoxylin and eosin and van Gieson (VG)–elastica stains as well as immunohistology for the expression of α–smooth muscle actin (α-SMA) were used to visualize the structures of arterial walls. Parasitology of fecal matter (11 llamas and 17 alpacas) confirmed that most of these animals were infested with both Dicrocoelium dendriticum and other gastrointestinal parasites. In most cases (10/12 llamas, 4/6 alpacas), liver enzyme activity in serum was elevated. Histologically, arteries in the lungs of 9 of 20 llamas (45%) and 3 of 20 alpacas (15%) showed severe intimal and adventitial and slight to moderate medial thickening, which was confirmed with α-SMA and VG-elastica staining. All animals exhibited typical liver changes, such as fibrosis and biliary hyperplasia, in association with the presence of liver flukes. This study shows that liver flukes can induce proliferative changes in lung arteries in NWCs that resemble those seen with pulmonary arterial hypertension due to liver parasites in humans. However, the degree of liver fluke infestation was not correlated with the extent of liver damage, or with the amount of thoracic or abdominal effusion or pulmonary arterial changes.