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Your search keyword '"Henderson, Bradford D."' showing total 2 results
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2 results on '"Henderson, Bradford D."'

1. Additional file 1 of Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC)

Author

Jackson, Isaac M., Lee, So Jeong, Sowa, Alexandra R., Rodnick, Melissa E., Bruton, Laura, Clark, Mara, Preshlock, Sean, Rothley, Jill, Rogers, Virginia E., Botti, Leslie E., Henderson, Bradford D., Hockley, Brian G., Jovany Torres, Raffel, David M., Brooks, Allen F., Frey, Kirk A., Kilbourn, Michael R., Koeppe, Robert A., Shao, Xia, and Scott, Peter J. H.

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2020
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2. An updated synthesis of [11 C]carfentanil for positron emission tomography (PET) imaging of the μ-opioid receptor

Author

Blecha, Joseph E., Henderson, Bradford D., Hockley, Brian G., VanBrocklin, Henry F., Zubieta, Jon-Kar, DaSilva, Alexandre F., Kilbourn, Michael R., Koeppe, Robert A., Scott, Peter J.H., and Shao, Xia

Subjects
Radiochemistry, C-11, Medicinal & Biomolecular Chemistry, Synthetic, Organic Chemistry, Receptors, Opioid, mu, Chemistry Techniques, Synthetic, Opioid, Chemistry Techniques, Pharmacology and Pharmaceutical Sciences, Article, PET radiochemistry, Fentanyl, Good Health and Well Being, mu, Positron-Emission Tomography, Receptors, radiosynthesis, Biomedical Imaging, Carbon Radioisotopes, carbon-11
Abstract

[(11)C]Carfentanil ([(11)C]CFN) is a selective radiotracer for in vivo positron emission tomography imaging studies of the μ-opioid system that, in our laboratories, is synthesized by methylation of the corresponding carboxylate precursor with [(11)C] MeOTf, and purified using a C2 solid-phase extraction cartridge. Changes in the commercial availability of common C2 cartridges have necessitated future proofing the synthesis of [(11)C]CFN to maintain reliable delivery of the radiotracer for clinical imaging studies. An updated synthesis of [(11)C]CFN is reported that replaces a now obsolete purification cartridge with a new commercially available version and also substitutes the organic solvents used in traditional production methods with ethanol.

Published
2017

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