1. Synthesis of new β-lactams bearing the biologically important morpholine ring and POM analyses of their antimicrobial and antimalarial activities
- Author
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Jarrahpour, A., Heiran, R., Véronique Sinou, Latour, C., Bouktab, L. D., Brunel, J. M., Sheikh, J., Hadda, T. B., Shiraz University of Technology (SUTech), Membranes et cibles thérapeutiques (MCT), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées (IRBA), Centre de Recherche en Cancérologie de Marseille (CRCM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU), Dhote Bandhu Science College, Université Mohammed Premier [Oujda], Shiraz University Research Council for financial support(GrantNo. 94-GR-SC-23), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
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2-Azetidinones ,β-Lactam ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,[CHIM.ORGA]Chemical Sciences/Organic chemistry ,Acylation ,POM analyses ,[SDV]Life Sciences [q-bio] ,[CHIM]Chemical Sciences ,[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology ,biochemical phenomena, metabolism, and nutrition ,Antimalarial activities ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology - Abstract
International audience; Some new β-lactams bearing biologically important morpholine ring have been synthesized by acylation of amino β-lactams in the presence of morpholine-4-carbonyl chloride. These novel β-lactams were prepared under mild reaction conditions without any solvent in short reaction times. Their biological activities have been examined against microbial agents such as Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa) and fungi such as Candida albicans (C. albicans) and Candida glabrata (C. glabrata). They have been also tested against Plasmodium falciparum K14 resistant strain and showed moderate to good IC 50 values.