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Endometrial cancer is a prevalent gynecologic cancer in the United States, with high incidence and mortality rates, particularly among postmenopausal women. Obesity is a significant risk factor for endometrial cancer, and studies have shown significant racial disparities in endometrial cancer outcomes. We utilized the Women’s Health Initiative study to compare baseline demographic and lifestyle factors, e.g., physical activity, body mass index, diet, alcohol consumption, smoking, education, etc.) across the four United States census geographic regions among women who were diagnosed with endometrial cancer (N=1803) compared to those without endometrial cancer (N=92,054). Our analysis revealed moderate differences in self-reported race and BMI between women with and without endometrial cancer. When comparing endometrial cancer patients across geographic regions, similar BMI trends were observed, but significant differences in self-reported race were only apparent in the West and South. We also found that the incidence and survival of endometrial cancer did not exhibit substantial variations based on geographic location, suggesting that region may not strongly influence these outcomes. While the Northeast and West had slightly higher incidence rates compared to the South and Midwest, these differences did not reach statistical significance. Additionally, the analysis of histology and stage revealed geographic disparities in the prevalence of serous/papillary serous carcinoma and disease stage, with the highest proportion being in the Northeast. However, overall survival rates did not significantly vary across geographic regions. Overall, these findings enhance our understanding of endometrial cancer epidemiology and underscore the significance of considering racial disparities and histologic subtypes in the study of this disease.

Supplemental material, sj-pdf-1-ctj-10.1177_1740774520988298 for Clinical trials in a COVID-19 pandemic: Shared infrastructure for continuous learning in a rapidly changing landscape by Haley Hedlin, Ariadna Garcia, Yingjie Weng, Ziyuan He, Vandana Sundaram, Bryan Bunning, Vidhya Balasubramanian, Kristen Cunanan, Kristopher Kapphahn, Santosh Gummidipundi, Natasha Purington, Mary Boulos and Manisha Desai in Clinical Trials

Supplemental material, sj-pdf-2-ctj-10.1177_1740774520988298 for Clinical trials in a COVID-19 pandemic: Shared infrastructure for continuous learning in a rapidly changing landscape by Haley Hedlin, Ariadna Garcia, Yingjie Weng, Ziyuan He, Vandana Sundaram, Bryan Bunning, Vidhya Balasubramanian, Kristen Cunanan, Kristopher Kapphahn, Santosh Gummidipundi, Natasha Purington, Mary Boulos and Manisha Desai in Clinical Trials

Supplemental material, sj-pdf-2-ctj-10.1177_1740774520988298 for Clinical trials in a COVID-19 pandemic: Shared infrastructure for continuous learning in a rapidly changing landscape by Haley Hedlin, Ariadna Garcia, Yingjie Weng, Ziyuan He, Vandana Sundaram, Bryan Bunning, Vidhya Balasubramanian, Kristen Cunanan, Kristopher Kapphahn, Santosh Gummidipundi, Natasha Purington, Mary Boulos and Manisha Desai in Clinical Trials

Supplemental material, sj-pdf-1-ctj-10.1177_1740774520988298 for Clinical trials in a COVID-19 pandemic: Shared infrastructure for continuous learning in a rapidly changing landscape by Haley Hedlin, Ariadna Garcia, Yingjie Weng, Ziyuan He, Vandana Sundaram, Bryan Bunning, Vidhya Balasubramanian, Kristen Cunanan, Kristopher Kapphahn, Santosh Gummidipundi, Natasha Purington, Mary Boulos and Manisha Desai in Clinical Trials