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Radiotherapy (RT) for head and neck cancer is now guided by cone-beam computed tomography (CBCT). We aim to identify a CBCT radiomic signature predictive of progression to RT. A cohort of 93 patients was split into training (n = 60) and testing (n = 33) sets. A total of 88 features were extracted from the gross tumor volume (GTV) on each CBCT. Receiver operating characteristic (ROC) curves were used to determine the power of each feature at each week of treatment to predict progression to radio(chemo)therapy. Only features with AUC > 0.65 at each week were pre-selected. Absolute differences were calculated between features from each weekly CBCT and baseline CBCT1 images. The smallest detectable change (C = 1.96 �� SD, SD being the standard deviation of differences between feature values calculated on CBCT1 and CBCTn) with its confidence interval (95% confidence interval [CI]) was determined for each feature. The features for which the change was larger than C for at least 5% of patients were then selected. A radiomics-based model was built at the time-point that showed the highest AUC and compared with models relying on clinical variables. Seven features had an AUC > 0.65 at each week, and six exhibited a change larger than the predefined CI 95%. After exclusion of inter-correlated features, only one parameter remains, Coarseness. Among clinical variable, only hemoglobin value was significant. AUC for predicting the treatment response were 0.78 (p = .006), 0.85 (p p p We described a feature selection methodology for delta-radiomics that is able to select reproducible features which are informative due to their change during treatment. A selected delta radiomics feature may improve clinical-based prediction models.

Between April 1988 and December 1991 42 patients underwent a bilateral lower eyelid blepharoplasty. Depending on the etiology either a skin-muscle-flap or a skin-flap technique was used. When the lid was lax, it was shortened by a wedge-resection to prevent postoperative ectropion. The results were satisfactory with either technique.

From the anatomical and physiological point of view th eyelid may be divided into three layers: a deep layer, comprising the tarsi and the canthal tendons with the levator aponeurosis and the lower lid retractors, the orbicularis muscle layer, and the skin. The surgical particularities of each of these layers are outlined. In the management of eyelid injuries the meticulous reconstruction of the medial canthal tendon and canthus is of paramount importance. Only after this are the lids closed from medially to laterally and from deep to superficial tissues.

The eye is an effective and frequently used means of communication. Innate ocular signals express basic feelings and are identical all over the world. Acquired signals depend on cultural status, intelligence, and education. Eye diseases and orbital anomalies can provide misleading impressions, because they can be confused with true eye signals or because they can trigger innate reaction mechanisms. Surgically, the eye can often be improved as an emittor of signals; the message, however, has to be composed by the patient.

Twenty patients underwent intubation of the lacrimal system with silicone stents. The preliminary results are favourable. New indications for intubation in lacrimal surgery are discussed.

Three unusual cases of posttraumatic upper eyelid retraction are described. They were observed following orbital trauma without apparent involvement of the superior rectus muscle after latency periods ranging from several months to years. As other reasons for the lid retraction were ruled out the question arises as to whether peripheral neurogenic or muscular upper eyelid retraction must be assumed to be a consequence of trauma, although this has never been described before.

The technique of intubation of the lacrimal system is described. A silicone tube with stainless steel probes on either end is used. Special emphasis is placed on management of difficulties in finding the probe in the nose and guiding it with a lacrimal groove director.

In a 55-year-old woman patient with congenital Horner's syndrome the ptosis and miosis disappeared completely for a short time after a bout of coughing. Pharmacologically the defect was localized in the second neuron. No etiology or pathogenetic mechanism of the phenomenon could be identified.