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2. Postantibiotic effects and postantibiotic sub-MIC effects of benzylpenicillin on viridans streptococci isolated from patients with infective endocarditis

Author

Totsuka K, Enari T, K. Shimizu, Y. Shibata, Ken Kikuchi, Katahira J, H. Hasegawa, Haruki K, and Minami S

Subjects
Pharmacology, Microbiology (medical), Time Factors, biology, medicine.drug_class, Antibiotics, Penicillin G, Endocarditis, Bacterial, Microbial Sensitivity Tests, medicine.disease, biology.organism_classification, Benzylpenicillin, Microbiology, Penicillin, Minimum inhibitory concentration, Infectious Diseases, Streptococcus oralis, Viridans streptococci, Infective endocarditis, medicine, Humans, Pharmacology (medical), Streptococcus sanguis, medicine.drug, Antibacterial agent
Abstract

We investigated the postantibiotic effects (PAEs) and the postantibiotic sub-MIC effects of benzylpenicillin on three strains of viridans streptococci isolated from infective endocarditis patients. The PAEs of benzylpenicillin on penicillin tolerant Streptococcus sanguis TW-70 (0.4-3.9 h), penicillin tolerant S. sanguis TW-80 (0.3-6.3 h) and nontolerant Streptococcus oralis TW-186 (0.5-3.1 h) were dependent on exposure time. The PAEs were not concentration dependent for S. sanguis TW-70 and S. sanguis TW-80 above the MIC, and for S. oralis TW-186 above 16 x MIC. The antimicrobial effects of benzylpenicillin at sub-MIC concentrations were examined in bacteria pretreated with benzylpenicillin (8 x MIC) for 2 h and compared with untreated bacteria. At the sub-MICs tested, the regrowth of pretreated S. oralis TW-186 cells was more prolonged than that of untreated cells and bactericidal action was seen only in pretreated cells. These effects (so-called 'postantibiotic' sub-MIC effects') were not observed in penicillin tolerant S. sanguis TW-70. The presence of the postantibiotic sub-MIC effect may be an important factor in determining the dosing regimen for infective endocarditis.

Published
1994

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