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Your search keyword '"Hanyu, Masayuki"' showing total 8 results
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8 results on '"Hanyu, Masayuki"'

1. Additional file 1 of Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin

Author

Ohkubo, Takayuki, Kurihara, Yusuke, Ogawa, Masanao, Nengaki, Nobuki, Fujinaga, Masayuki, Mori, Wakana, Kumata, Katsushi, Hanyu, Masayuki, Furutsuka, Kenji, Hashimoto, Hiroki, Kawamura, Kazunori, and Zhang, Ming-Rong

Abstract

Additional file 1: Figure S1. The system diagram of automated multi-purpose synthesizer developed in-house (Fukumura et al. 2007). Figure S2. The preparative HPLC chromatogram of [18F]FMISO synthesized by 18F-fluorination using 1 and [18F]F-, followed by the removal of the protecting group in [18F]3. The HPLC conditions were as follows: XBridge C18 column (5 μm, 10 mm i.d. × 250 mm length; Waters), with a mixture of ethanol and water (2:98, vol./vol.) as the mobile phase, a flow rate of 5.0 mL/min, and UV detection at 325 nm. Figure S3. The preparative HPLC chromatograms of [18F]PM-PBB3 synthesized by 18F-fluorination using 2 and [18F]F-, followed by the removal of the protecting group in [18F]4. The HPLC conditions were as follows: Capcell Pak C18 column (5 μm, 10 mm i.d. × 250 mm length; Shiseido, Tokyo, Japan), the mixture of acetonitrile, water and triethylamine (40:60:0.1, v/v/v) as the mobile phase, 5.0 mL/min flow rate, and UV detection at 365 nm.

Published
2021
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2. Developing native peptide-based radiotracers for PD-L1 PET imaging and improving imaging contrast by pegylation

Author

Kuan, Hu, Hu, Kuan, Masayuki, Hanyu, Hanyu, Masayuki, Lin, Xie, Yiding, Zhang, Kotaro, Nagatsu, Nagatsu, Kotaro, Hisashi, Suzuki, Suzuki, Hisashi, and Ming-Rong, Zhang

Subjects
chemistry.chemical_classification, Biodistribution, biology, 010405 organic chemistry, Metals and Alloys, Peptide, General Chemistry, Pet imaging, Pharmacology, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, Pharmacokinetics, PD-L1, Materials Chemistry, Ceramics and Composites, biology.protein, PEGylation, In vivo pharmacokinetics
Abstract

Herein, a PD-L1 targeted native peptide was developed for PET imaging. 18F and 64Cu were utilized to label the peptide. To improve the pharmacokinetics and biodistribution of the tracers, the peptide was further pegylated to form star-like tetramers. Consequently, four tracers were synthesized with acceptable radiochemical characteristics and their in vivo pharmacokinetics and PD-L1 imaging capability were systematically evaluated. This proof-of-principle study may provide new possibilities for PD-L1 PET imaging in cancers.

Published
2019

3. Additional file 4: Figure S3. of Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Author

Koga, Kazumi, Maeda, Jun, Tokunaga, Masaki, Hanyu, Masayuki, Kawamura, Kazunori, Ohmichi, Mari, Nakamura, Toshio, Nagai, Yuji, Seki, Chie, Kimura, Yasuyuki, Minamimoto, Takafumi, Ming-Rong Zhang, Fukumura, Toshimitsu, Suhara, Tetsuya, and Higuchi, Makoto

Abstract

Analytical HPLC chromatogram of [11C]TASP0390136. (PDF 557 kb)

Published
2016
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4. Additional file 2: Figure S1. of Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Author

Koga, Kazumi, Maeda, Jun, Tokunaga, Masaki, Hanyu, Masayuki, Kawamura, Kazunori, Ohmichi, Mari, Nakamura, Toshio, Nagai, Yuji, Seki, Chie, Kimura, Yasuyuki, Minamimoto, Takafumi, Ming-Rong Zhang, Fukumura, Toshimitsu, Suhara, Tetsuya, and Higuchi, Makoto

Abstract

Analytical HPLC chromatogram of [11C]TASP0410457. (PDF 527 kb)

Published
2016
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5. Additional file 2: Figure S1. of Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Author

Koga, Kazumi, Maeda, Jun, Tokunaga, Masaki, Hanyu, Masayuki, Kawamura, Kazunori, Ohmichi, Mari, Nakamura, Toshio, Nagai, Yuji, Seki, Chie, Kimura, Yasuyuki, Minamimoto, Takafumi, Ming-Rong Zhang, Fukumura, Toshimitsu, Suhara, Tetsuya, and Higuchi, Makoto

Abstract

Analytical HPLC chromatogram of [11C]TASP0410457. (PDF 527 kb)

Published
2016
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6. Additional file 3: Figure S2. of Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Author

Koga, Kazumi, Maeda, Jun, Tokunaga, Masaki, Hanyu, Masayuki, Kawamura, Kazunori, Ohmichi, Mari, Nakamura, Toshio, Nagai, Yuji, Seki, Chie, Kimura, Yasuyuki, Minamimoto, Takafumi, Ming-Rong Zhang, Fukumura, Toshimitsu, Suhara, Tetsuya, and Higuchi, Makoto

Abstract

Analytical HPLC chromatogram of [11C]TASP0434988. (PDF 542 kb)

Published
2016
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7. Additional file 4: Figure S3. of Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Author

Koga, Kazumi, Maeda, Jun, Tokunaga, Masaki, Hanyu, Masayuki, Kawamura, Kazunori, Ohmichi, Mari, Nakamura, Toshio, Nagai, Yuji, Seki, Chie, Kimura, Yasuyuki, Minamimoto, Takafumi, Ming-Rong Zhang, Fukumura, Toshimitsu, Suhara, Tetsuya, and Higuchi, Makoto

Abstract

Analytical HPLC chromatogram of [11C]TASP0390136. (PDF 557 kb)

Published
2016
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8. Additional file 3: Figure S2. of Development of TASP0410457 (TASP457), a novel dihydroquinolinone derivative as a PET radioligand for central histamine H3 receptors

Author

Koga, Kazumi, Maeda, Jun, Tokunaga, Masaki, Hanyu, Masayuki, Kawamura, Kazunori, Ohmichi, Mari, Nakamura, Toshio, Nagai, Yuji, Seki, Chie, Kimura, Yasuyuki, Minamimoto, Takafumi, Ming-Rong Zhang, Fukumura, Toshimitsu, Suhara, Tetsuya, and Higuchi, Makoto

Abstract

Analytical HPLC chromatogram of [11C]TASP0434988. (PDF 542 kb)

Published
2016
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