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Introduction: Embarrassment is a social affect. Once experienced in social interactions (SIs), it can be a precursor of clinical symptoms like depersonalization and ruminative thinking. This experience sampling study investigated predictors of embarrassment in social phobia (SP), major depressive disorder (MDD), and controls. Methods: For seven days, a total of n = 165 patients (n = 47 SP, n = 118 MDD) and n = 119 controls completed five surveys per day on their smartphones. The effect of social anxiety and depression facets on embarrassment was examined in contemporaneous and time-lagged models. Results: Individuals with SP or MDD experienced more embarrassing SIs than controls. Among facets of depression, feelings of guilt, and low self-worth significantly predicted embarrassment in contemporaneous, but not in time-lagged models. Among facets of social anxiety, worries about other people's opinion and worries of saying or doing something wrong during a social interaction significantly predicted embarrassment (contemporaneous and time-lagged; all p < .05). Discussion: The study reveals important cognitive factors that accompany embarrassment in SIs and that connect social experience and clinical symptoms. Targeting these putative dysfunctions could be an important strategy in therapy. The differential patterns in SP and MDD are discussed.

Background Increasing globalization has led to more families with children being relocated each year, highlighting the importance of issues, such as adjustment and psychological well-being, in this population. These children, commonly known as third culture kids, often spend a significant part of their developmental years in countries and cultures foreign to them. Objective Our longitudinal study aims to examine the roles of cognitive, psychological, sociocultural, and family factors in the longitudinal trajectories of the well-being and sociocultural adjustment of third culture kids and their families over time. Methods This study adopts both quantitative and qualitative procedures. Data from both procedures will be collected at baseline and at a 1-year follow-up. We aim to recruit 150 to 200 participants between 7 and 17 years old and one of their primary caregivers. After providing informed consent, participants will complete an online survey. Outcome measures include validated questionnaires on well-being and sociocultural adjustment. Predictor measures include validated questionnaires on negative self-thoughts, emotion regulation, resilience, psychological attributes, self-esteem, stress, acculturative stress, cultural intelligence, couple satisfaction, and family functioning. A multiple regression model will be used to analyze quantitative data. In addition, 15 to 20 families who participate in the online survey will be randomly selected to take part in a family interview focusing on questions related to well-being, relocation experiences, cultural issues, and challenges. A concurrent triangulation mixed methods design will be used to analyze and interpret data from both quantitative and qualitative methods. Results As of March 15, 2022, a total of 138 children and 126 parents have completed the baseline online survey. In addition, 44 children and 48 parents have completed the 1-year follow-up online survey. A total of 8 families have completed the baseline family interview, while 4 families have completed the 1-year follow-up interview. Data analyses, transcription of the interview, and preparation for publication are on-going. Conclusions Findings from this study would enable us to understand the adjustment processes, and risk and protective factors associated with the well-being and sociocultural adjustment of third culture kids and their families in Switzerland, which could have implications on the development of intervention programs for individuals and families to address acculturation and adjustment issues. International Registered Report Identifier (IRRID) RR1-10.2196/30088

BACKGROUND Increasing globalization has led to more families with children being relocated each year, highlighting the importance of issues, such as adjustment and psychological well-being, in this population. These children, commonly known as third culture kids, often spend a significant part of their developmental years in countries and cultures foreign to them. OBJECTIVE Our longitudinal study aims to examine the roles of cognitive, psychological, sociocultural, and family factors in the longitudinal trajectories of the well-being and sociocultural adjustment of third culture kids and their families over time. METHODS This study adopts both quantitative and qualitative procedures. Data from both procedures will be collected at baseline and at a 1-year follow-up. We aim to recruit 150 to 200 participants between 7 and 17 years old and one of their primary caregivers. After providing informed consent, participants will complete an online survey. Outcome measures include validated questionnaires on well-being and sociocultural adjustment. Predictor measures include validated questionnaires on negative self-thoughts, emotion regulation, resilience, psychological attributes, self-esteem, stress, acculturative stress, cultural intelligence, couple satisfaction, and family functioning. A multiple regression model will be used to analyze quantitative data. In addition, 15 to 20 families who participate in the online survey will be randomly selected to take part in a family interview focusing on questions related to well-being, relocation experiences, cultural issues, and challenges. A concurrent triangulation mixed methods design will be used to analyze and interpret data from both quantitative and qualitative methods. RESULTS As of March 15, 2022, a total of 138 children and 126 parents have completed the baseline online survey. In addition, 44 children and 48 parents have completed the 1-year follow-up online survey. A total of 8 families have completed the baseline family interview, while 4 families have completed the 1-year follow-up interview. Data analyses, transcription of the interview, and preparation for publication are on-going. CONCLUSIONS Findings from this study would enable us to understand the adjustment processes, and risk and protective factors associated with the well-being and sociocultural adjustment of third culture kids and their families in Switzerland, which could have implications on the development of intervention programs for individuals and families to address acculturation and adjustment issues. INTERNATIONAL REGISTERED REPORT RR1-10.2196/30088

Dieses Kapitel gibt einen Uberblick uber die Transposition der grosen Arterien. Hierbei werden die Anatomie, die klinische Situation der betroffenen Patienten, die diagnostischen und therapeutischenoglichkeiten erortert. Zudem gibt es Informationen zu Assoziationen mit weiteren Fehlbildungen und Empfehlungen zur Endokarditisprophylaxe.

Dieses Kapitel gibt einen Uberblick uber deb Double Outlet Right Ventricle. Hierbei werden die Anatomie, die klinische Situation der betroffenen Patienten, die diagnostischen und therapeutischen Moglichkeiten erortert. Zudem gibt es Informationen zu Assoziationen mit weiteren Fehlbildungen und Empfehlungen zur Endokarditisprophylaxe.

Dieses Kapitel gibt einen Uberblick uber den Truncus arteriosus communis. Hierbei werden die Anatomie, die klinische Situation der betroffenen Patienten, die diagnostischen und therapeutischen Moglichkeiten erortert. Zudem gibt es Informationen zu Assoziationen mit weiteren Fehlbildungen und Empfehlungen zur Endokarditisprophylaxe.

Dieses Kapitel gibt einen Uberblick uber die Mitralstenose. Hierbei werden die Anatomie, die klinische Situation der betroffenen Patienten, die diagnostischen und therapeutischen Moglichkeiten erortert. Zudem gibt es Informationen zu Assoziationen mit weiteren Fehlbildungen und Empfehlungen zur Endokarditisprophylaxe.

Dieses Kapitel gibt einen Uberblick uber die Pulmonalatresie mit Ventrikelseptumdefekt. Hierbei werden die Anatomie, die klinische Situation der betroffenen Patienten, die diagnostischen und therapeutischen Moglichkeiten erortert. Zudem gibt es Informationen zu Assoziationen mit weiteren Fehlbildungen und Empfehlungen zur Endokarditisprophylaxe.

New technique of diffuse reflectance spectroscopic analysis of milk fat and total protein content in the visible (Vis) and adjacent near infrared (NIR) region (400-995nm) has been developed and tested. Sample analysis was performed through a probe having eight 200-µm fiber channels forming a linear array. One of the end fibers was used for the illumination and other seven - for the spectroscopic detection of diffusely reflected light. One of the detection channels was used as a reference to normalize the spectra and to convert them into absorbance-equivalent units. The method has been tested experimentally using a designed sample set prepared from industrial raw milk standards with widely varying fat and protein content. To increase the modelling robustness all milk samples were measured in three different homogenization degrees. Comprehensive data analysis has shown the advantage of combining both spectral and spatial resolution in the same measurement and revealed the most relevant channels and wavelength regions. The modelling accuracy was further improved using joint variable selection and preprocessing optimization method based on the genetic algorithm. The root mean-square errors of different validation methods were below 0.10% for fat and below 0.08% for total protein content. Based on the present experimental data, it was computationally shown that the full-spectrum analysis in this method can be replaced by a sensor measurement at several specific wavelengths, for instance, using light-emitting diodes (LEDs) for illumination. Two optimal sensor configurations have been suggested: with nine LEDs for the analysis of fat and seven - for protein content. Both simulated sensors exhibit nearly the same component determination accuracy as corresponding full-spectrum analysis.

Nowadays the Zika virus (ZIKV) has been one of the most studied vector-borne diseases due to the considerable outbreaks that have generated around the world as well as due to the new transmission mechanisms and health complications originated. According to statistics of the INS-Colombia for July 2016, 68% of the population infected by ZIKV (confirmed cases) are pregnant women. Furthermore, the Quindio department belongs to the states with more than 50% of the total infected persons being pregnant women. Taking into account those characteristics, a theoretical model is proposed and analyzed to describe the population dynamics considering the sexual and vectorial transmission of ZIKV, with special emphasis in the consequences of the non-vectorial transmission in the population. The obtained results with simulations through the beta parameter indicate that the probability of sexual transmission between susceptible women and infected men points out the importance of campaigns to inculcate prevention measures for the safe sexual relationships between ZIKV infected population.

Monitoring analytes during the transfer step from the first to the second dimension in multidimensional electrophoretic separations is crucial to determine and control the optimal time point for sample transfer and thus to avoid band broadening or unwanted splitting of the sample band with consequent sample loss. A spatially resolved intermediate on-chip LED-induced fluorescence detection system was successfully implemented for a hybrid capillary-chip glass interface. The setup includes a high-power 455-nm LED prototype as an excitation light source and a linear light fiber array consisting of 23 light fibers with a diameter of 100 μm for spatially resolved fluorescence detection in combination with a push-broom imager for hyperspectral detection. Using a basic FITC solution, the linear working range was determined to be 0.125 to 25 μg/ml for a single light guide and the absolute detection limit was 0.04 fmol at a signal-to-noise ratio of 4. With the setup presented here, labeled β-lactoglobulin focused via capillary isoelectric focusing was detectable on-chip with a sufficient intensity to monitor the analyte band transfer in the glass-chip interface demonstrating its applicability for full or intermediate on-chip detection. Fil: Sydes, Daniel. Eberhard Karls Universität Tübingen; Alemania Fil: Kler, Pablo Alejandro. Eberhard Karls Universität Tübingen; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; Argentina Fil: Meyer, Hans. J&M Analytik AG; Alemania Fil: Zipfl, Peter. University of Applied Sciences Aalen. Optoelectronics and Laser Technology Department; Alemania Fil: Lutz, Daniel. CalvaSens GmbH; Alemania Fil: Huhn, Carolin. Eberhard Karls Universität Tübingen; Alemania

It has been introduced and analyzed a mathematical model based on integral equations, which turns into a dynamical system of non-linear differential equations to account for the risk of microcephaly incidence caused by the Zika virus. A specific pregnant women susceptible group has been accounted for. The epidemic threshold (basic reproduction number) has been obtained by implementing the next generation matrix method. A sensitivity analysis with respect to each parameter has been applied to that threshold. Finally, the incidence to the exposure is obtained by performing several system simulations.

It is set and analyzed a simulation model based on non-linear ordinary differential equations to interpret the dynamics of the microcephaly incidence caused by the Zika virus in a risk group of pregnant women. This one is induced by a population of men in a reproductive age. Also, some parameters of the model were estimated for an average temperature of 23℃ and by using the adjusted functions from references [1] [2]. All system simulations were done with the Maple software and parameters values obtained from several sources (estimated, hypothetic, and form literature). It has been found that the application of contraceptive measures impacts the population of sexually active women. As result, the exposure to congenital abnormalities increases, particularly, microcephaly.

The German Federal Cartel Office and the Austrian Federal Competition Authority have recently published a draft "Guidance on Transaction Value Thresholds for Mandatory Pre-merger Notification (Section 35(1a) GWB and Section 9(4) KartG)" for public consultation. Prof. Dr. Christian Kersting, Prof. Dr. Hans Jurgen Meyer-Lindemann and Prof. Dr. Rupprecht Podszun of the Dusseldorf Institute for Competition Law evaluate the draft guidance. The draft of the guidance is available on the homepage of the Federal Cartel Office.

Three prototypes of mid-infrared (MIR) spectrometric sensor systems for simultaneous monitoring of ethanol and carbohydrates (in the present case glucose and fructose) in the course of biotechnological processes have been constructed based on recent developments in pyroelectric detection and fiber photonics. The sensors utilized were a grating spectrometer or a Fabry-Perot interferometer adjusted for the detection of analytes’ characteristic absorbance bands in the spectral region of “fingerprints” between 1050 and 950 cm −1 . The measurements were performed with an attenuated total reflection (ATR) probe connected to the spectrometer by a polycrystalline infrared fiber (PIR). Two probes with different ATR elements were tested: with a diamond crystal (for both spectrometers) and with a detachable PIR loop head (for grating spectrometer). The sensor performances were assessed and compared using partial least-squares (PLS) regression modeling and prediction statistics for two designed sample sets of binary ethanol–glucose and glucose–fructose aqueous solutions. The models based on the FT-IR spectroscopic analysis of the same designed samples using a diamond ATR probe (a “gold standard” method) were used as a benchmark. The system based on a grating spectrometer connected to an ATR probe with a PIR loop head was additionally tested under the process conditions of Saccharomyces cerevisiae fermentation. The resulting root mean-square errors of prediction were 4.74 and 13.33 g/L, for ethanol and glucose models, respectively. Simultaneously, NIR spectroscopy in the range 1100–2100 nm was used both for the analysis of designed samples and for the fermentation process monitoring. In the latter case a biomass content prediction model has been built along with those for ethanol and glucose. All tested full-spectroscopic and sensor-based methods of analysis have been compared and their practical applications discussed.

Contenu et objectifs de la geographie coloniale comme enseignement §1. La fureur de la guerre, dont le dechainement fait trembler la terre depuis neuf mois deja, a aussi embrase nos colonies. Meme la plus grande Allemagne en outre-mer a subi l’assaut conjoint de l’Angleterre, de la France et du Japon, apres que l’avidite et la perfidie britanniques ont declare nul et non avenu l’acte de navigation du Congo ratifie par l’Angleterre, qui etablissait la neutralite du bassin du Congo, du Cameroun...