4 results on '"Hajat, Cother"'
Search Results
2. Analysis of common methodological faws in the highest cited e‑cigarette epidemiology research
- Author
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Hajat, Cother, Stein, Emma, Selya, Arielle, Polosa, Riccardo, and The CoEHAR study group
- Abstract
The prevalence of vaping, also known as using e-cigarettes, vapes and vape pens, has prompted a demand for reliable, evidence-based research. However, published literature on the topic of vaping often raises concerns, characterized by serious flaws and a failure to adhere to accepted scientific methodologies. In this narrative review, we analyze popular vaping studies published in medical journals that purport to evaluate the association of vaping and smoking cessation, smoking initiation or health outcomes. We analyzed 24 included studies to identify the questions they claimed to address, stated methods, manner of implementation, discussions, and stated conclusions. After critical appraisal, we noted a multiplicity of flaws in these studies, and identified patterns as to the nature of such flaws. Many studies lacked a clear hypothesis statement: to the extent that a hypothesis could be inferred, the methods were not tailored to address the question of interest. Moreover, main outcome measures were poorly identified, and data analysis was further complicated by failure to control for confounding factors. The body of literature on “gateway” theory for the initiation of smoking was particularly unreliable. Overall, the results and discussion contained numerous unreliable assertions due to poor methods, including data collection that lacked relevance, and assertions that were unfounded. Many researchers claimed to find a causal association while not supporting such findings with meaningful data: the discussions and conclusions of such studies were, therefore, misleading. Herein, we identify the common flaws in the study design, methodology, and implementation found in published vaping studies. We present our summary recommendations for future vaping research. Our aim is to prompt future researchers to adhere to scientific methods to produce more reliable findings and conclusions in the field of vaping research.
- Published
- 2022
3. Critical analysis of common methodology flaws in e-cigarette surveys
- Author
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Phillips, Carl V, Hajat, Cother, Stein, Emma, Polosa, Riccardo, and The CoEHAR study group
- Abstract
The prevalence of vaping, also known as using e-cigarettes, vapes, vape pens, or electronic nicotine delivery systems (ENDS) has prompted a demand for reliable, evidence-based research.1However, published literature on the topic of vaping is often unreliable, characterized by serious flaws and a failure to adhere to accepted scientific methodologies. In this narrative review, we analyze 24 popular vaping studies, published in medical journals, that purport to evaluate the association of vaping and smoking initiation, smoking cessation or health outcomes. We analyzed these studies to identify the questions they claimed to address, stated methods, manner of implementation, discussions, and stated conclusions. After critical appraisal, we noted a multiplicity of flaws in these studies, and identified patterns as to the nature of such flaws. Many studies lacked a clear hypothesis statement: to the extent that a hypothesis could be inferred, the methods were not tailored to address the question of interest. Moreover, main outcome measures were poorly identified, and data analysis was further complicated by failure to control for confounding factors. The body of literature on “gateway” theory the for initiation of smoking was particularly unreliable. Overall, the results and discussion contained numerous unreliable assertions due to poor methods, including data collection that lacked relevance, and assertions that were unfounded. Many researchers claimed to find a causal association while not supporting such findings with meaningful data: the discussions and conclusions of such studies were therefore misleading. Herein, we identify the common flaws in the study design, methodology, and implementation found in published vaping studies. Our aim is to prompt future researchers to adhere to scientific methods to produce more reliable findings and conclusions in the field of vaping research
- Published
- 2021
4. The Health Impact of Smokeless Tobacco Products: A Systematic Review
- Author
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Hajat, Cother, Stein, Emma, Ramstrom, Lars, Shantikumar, Saran, and Polosa, Riccardo
- Subjects
Tobacco, Smokeless ,Snuff ,genetic structures ,Smoking ,Public Health, Environmental and Occupational Health ,Medicine (miscellaneous) ,Tobacco Products ,Review ,Cardiovascular disease ,Psychiatry and Mental health ,Tobacco Use ,Head and Neck Neoplasms ,Tobacco harm reduction ,Smokeless tobacco ,Tobacco ,Humans ,Mental health ,Public aspects of medicine ,RA1-1270 ,Snus ,Mortality ,Moist snuff ,Respiratory disease ,Cancer - Abstract
Introduction The objective was to systematically review studies on health outcomes from smokeless tobacco (SLT) products. Methods We analysed published literature on the health outcomes from SLT use between 01/01/2015 to 01/02/2020, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol using PubMed, Embase, Scopus, and Google Scholar. Results Of 53 studies included, six were global, 32 from Asia, Middle East and Africa (AMEA), nine from USA and six from Europe. ‘Poor’-rated studies predominated (23;43%), in particular, for global (4;66%) and AMEA (16;50%). Health outcomes differed between SLT-products and regions; those in AMEA were associated with higher mortality (overall, cancer, Coronary heart disease (CHD), respiratory but not cardiovascular disease (CVD)), and morbidity (CVD, oral and head and neck cancers), with odds ratios up to 38.7. European studies showed no excess mortality (overall, CVD, from cancers) or morbidity (ischemic heart disease (IHD), stroke, oral, head and neck, pancreatic or colon cancers) from several meta-analyses; single studies reported elevated risk of rectal cancer and respiratory disorders. Pooled study data showed protection against developing Parkinson’s disease. US studies showed mixed results for mortality (raised overall, CHD, cancer and smoking-related cancer mortality; no excess risk of respiratory or CVD mortality). Morbidity outcomes were also mixed, with some evidence of increased IHD, stroke and cancer risk (oral, head and neck). No studies reported on switching from cigarettes to SLT-products. Conclusion Our review demonstrates stark differences between different SLT-products in different regions, ranging from zero harm from European snus to greatly increased health risks in AMEA. The literature on the safety profile for SLT-products for harm reduction is incomplete and potentially misinforming policy and regulation.
- Published
- 2021
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