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3. OC-0533 Two Centre Feasibility study of single fraction lung stereotactic ablative radiotherapy (SABR)

Author

E. Aynsley, R. Akasha, A. Blower, H. Grimes, D. Johnson, S. Petkar, S. Moinuddin, S. Masinghe, N. Lalli, Z. Jani, Clive Peedell, C. Hiley, S. Dubash, M. Chiu, G. Kumar, and J. Wilson

Subjects
Lung, business.industry, medicine.medical_treatment, Hematology, SABR volatility model, Single fraction, Radiation therapy, medicine.anatomical_structure, Oncology, Ablative case, medicine, Radiology, Nuclear Medicine and imaging, Nuclear medicine, business
Published
2021
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4. Education Abroad Co-Curricular Experiences That Result in Intercultural Responsive Leadership Growth

Author

Lee H. Grimes and Teresa E. Simpson

Subjects
050106 general psychology & cognitive sciences, business.industry, Political science, Pedagogy, 05 social sciences, 050301 education, 050109 social psychology, 0501 psychology and cognitive sciences, Public relations, business, 0503 education
Abstract

To better prepare the educators who will guide students into their global future, educational leadership programs have become more focused on developing globally competent students who are not only more marketable, but who are also better prepared to make positive contributions to a global society. This chapter portrays that cross institutions in America there is a need to prepare students more adequately for the challenges of an increased global workforce. In the chapters, we follow the experiences of two scholars as they progressed through their development of becoming intercultural responsive educators by means of a study abroad program. From this experience, reflection questions encompass self-reflection about global perspectives. Also, interactions of others who hold various interests, values, and perspectives as they related to their growth in leadership. Situational leadership as a part of a critical skill set will also be examined.

Published
2020
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5. Corrigendum to '73 - Five years of stereotactic radiotherapy for early lung cancer: Biopsy rates, outcomes and implications' [Lung Cancer, 139, 1, (January 2020) Page S31]

Author

S. Lock, Neal Navani, A. Colori, U. Johnson, Z. Tan, Z. Jani, D. Carnell, H. Grimes, D. D’Souza, P. Bhudia, K. Quingua, C. Hiley, R. Mendes, P. Leonard, and K. McGeady

Subjects
Pulmonary and Respiratory Medicine, Cancer Research, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Early lung cancer, medicine.disease, Stereotactic radiotherapy, Oncology, Biopsy, medicine, Radiology, Lung cancer, business
Published
2020
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8. Immunoglobulins in healthy controls: HLA-B8 and sex differences Me HI rat wit ryl; riei ser

Author

H. Grimes, Eilis M. Cryan, Mary Bourke, Ciaran F. Mccarthy, Fiona M. Stevens, and Rena Skehill

Subjects
medicine.medical_specialty, biology, Incidence (epidemiology), Immunology, General Medicine, Human leukocyte antigen, Immunoglobulin E, biology.organism_classification, Biochemistry, Endocrinology, Antigen, Internal medicine, Tasa, Genetics, medicine, biology.protein, Immunology and Allergy, Antibody
Abstract

Serum immunoglobulins were measured in one hundred and eighty-four healthy controls. One hundred and fifty-nine of these were also HLA typed. IgG levels did not differ with sex or HLA-B8 status. IgM levels did not differ with HLA-B8 status but were significantly higher in females than males. IgA levels were lower in females than males; they were also lower in HLA-B8 positive compared with HLA-B8 negative individuals; the lowest IgA levels were found in HLA-B8 positive females. The IgA variation may be relevant to the higher incidence of certain disorders among HLA-B8 positive individuals and among females.

Published
2008
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10. THE INTERPRETATION AND MAPPING OF VEGETATION AND OTHER GROUND SURFACE FEATURES FROM AIR PHOTOGRAPHS OF MOUNTAINOUS AREAS IN NORTH WALES

Author

R. Goodier and B. H. Grimes

Subjects
Geography, Earth and Planetary Sciences (miscellaneous), Classification scheme, Vegetation, Computers in Earth Sciences, Engineering (miscellaneous), Cartography, Computer Science Applications
Abstract

The paper describes work undertaken in North Wales in 1967 and 1968 in which panchromatic and colour air photographs were used in the mapping of vegetation and in the study of other ground surface features. The problems of relating a priori classification schemes to the categories distinguished by air photo-interpretation are discussed and the case stated for developing classifications which enable more benefit to be derived from the advantages of air photo-ecology. Resume Cette communication decrit quelques etudes de la vegetation et d'autres proprietes de la surface terrestre faites dans le nord du pays des Galles en 1967 et 1968, au moyen des photos aeriennes panchrometiques et en couleur. Les auteurs discutent le probleme general de classification des formes par rapport aux photos aeriennes.

Published
2006
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11. Novel route to the synthesis of 4-quinolyl isothiocyanates

Author

Chuan Shih, Michal Vieth, Chafiq Hamdouchi, Boyu Zhong, Rima S. Al-awar, and John H. Grimes

Subjects
Thiocyanate, Organic Chemistry, General Medicine, Combinatorial chemistry, Biochemistry, Toluene, chemistry.chemical_compound, chemistry, Silver thiocyanate, Yield (chemistry), Drug Discovery, Isothiocyanate, Organic chemistry, Reactivity (chemistry)
Abstract

4-Quinolyl isothiocyanates were synthesized in a regiospecific fashion from the corresponding 4-chloroquinolines and silver thiocyanate in refluxing toluene. The products were isolated in quantitative yield and high purity (>95%) by simple filtration and concentration. Reactivity and mechanism of the reaction are discussed. The new approach would provide a new mean which had been lacking for the synthesis of functionalized 4-quinolinyl isothiocyanate.

Published
2006
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12. Solid-phase synthesis of a type II′ β-turn peptido-mimetic library

Author

John H. Grimes, Yvonne M. Angell, and Wayne David Kohn

Subjects
Pictet–Spengler reaction, Dipeptide, Chemistry, Stereochemistry, Organic Chemistry, Tryptophan, Combinatorial synthesis, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, Solid-phase synthesis, Drug Discovery, Aspartic acid, Moiety, Stereoselectivity
Abstract

The solid-phase synthesis of a dipeptide derived 2-amino-3-oxohexahydroindolizino[8,7-b]indole-5-carboxylate system (IBTM) is described. The IBTM moiety is formed via a solid-phase mediated Pictet–Spengler reaction of N-terminal tryptophan and the 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl (Dmab) ester of Fmoc protected aspartic acid β-aldehyde followed by γ-lactamization. This synthesis allows the regio- and stereoselective incorporation of a dipeptide surrogate of type II′ β-turns. The procedure is easily adaptable to combinatorial synthesis and a 576-member library was synthesized.

Published
2003
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13. DETECTION OF CRYPTOSPORIDIUM PARVUM AND GIARDIA LAMBLIA CARRIED BY SYNANTHROPIC FLIES BY COMBINED FLUORESCENT IN SITU HYBRIDIZATION AND A MONOCLONAL ANTIBODY

Author

Norman J. Pieniazek, Alexandre J. da Silva, Thaddeus K. Graczyk, Barbara H. Grimes, Duncan A. Veal, and Ronald Knight

Subjects
biology, animal diseases, fungi, Giardia, Cryptosporidium, biology.organism_classification, medicine.disease_cause, Virology, digestive system diseases, Microbiology, Apicomplexa, chemistry.chemical_compound, fluids and secretions, Infectious Diseases, Cryptosporidium parvum, chemistry, parasitic diseases, Genotype, medicine, Giardia lamblia, Protozoa, Parasitology, Fluorescein isothiocyanate
Abstract

Wild-caught synanthropic flies were tested for the presence of Cryptosporidium parvum and Giardia lamblia on their exoskeletons and in their digestive tracks by fluorescent in situ hybridization and fluorescein isothiocyanate (FITC)-conjugated monoclonal antibody (MAb) against Cryptosporidium and Giardia cell wall epitopes. The levels of C. parvum were positively correlated with the levels of G. lamblia, indicating a common source of contamination. The majority of oocysts and cysts were potentially viable (C. parvum = 80% and G. lamblia = 69%). More G. lamblia cysts occurred on the exoskeleton of the flies than within the digestive tracts; the opposite relationship was observed for C. parvum. No genotype other than C. parvum G2 was found to be associated with flies. Because filth flies carry viable C. parvum oocysts and G. lamblia cysts acquired naturally from unhygienic sources, they can be involved in the epidemiology of cryptosporidiosis and giardiasis. Fluorescent oligonucleotide probes used together with FITC-conjugated MAb represent a convenient and cost-effective technique for rapid and specific identification of human-infectious species of Cryptosporidium and Giardia mechanically transported by flies, and for the assessment of the viability of these pathogens.

Published
2003
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14. Effects of centralized and onsite wastewater treatment on the occurrence of traditional and emerging contaminants in streams

Author

G M, Ferrell and B H, Grimes

Subjects
Pharmaceutical Preparations, Rivers, North Carolina, Organic Chemicals, Wastewater, Waste Disposal, Fluid, Water Pollutants, Chemical
Abstract

The authors conducted a survey of small streams to evaluate the effects of centralized and onsite wastewater treatment on the occurrence of selected traditional and emerging contaminants in small streams in the upper Neuse River basin, North Carolina. An undeveloped site was included to assess effects of residential land use activities on stream quality. Concentrations of nutrients and ions were higher in samples from streams in residential sites than from the stream in an undeveloped area. Overall, streams draining residential areas showed relatively small differences with respect to type of wastewater treatment. Two sites, however--one in an area of centralized wastewater treatment apparently near a suspected sewer line leak, and the second in an area of onsite wastewater treatment--showed effects of wastewater. Organic wastewater compounds were detected more frequently in samples from these two sites than from the other sites. Optical brighteners levels were correlated (r2 = .88) with the number of organic wastewater and pharmaceutical compounds detected at the residential sites and could potentially serve as a screening method to assess wastewater effects on small streams.

Published
2014

15. EP-1664: Radiotherapy treatment verification in a cohort of limb sarcoma patients: an audit of departmental practice

Author

S. Petkar, S. Nash, F. Le Grange, H. Grimes, Beatrice Seddon, and S. Moinuddin

Subjects
medicine.medical_specialty, business.industry, General surgery, Hematology, Audit, medicine.disease, Surgery, Oncology, Radiology Nuclear Medicine and imaging, Cohort, medicine, Radiology, Nuclear Medicine and imaging, Radiotherapy treatment, Sarcoma, business
Published
2015
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16. Water-quality characteristics indicative of wastewater in selected streams in the upper Neuse River Basin, Durham and Orange Counties, North Carolina, from 2004 to 2013

Author

Alexandria K. Graves, Matthew S. Yearout, Michael T. Meyer, Barbara H. Grimes, Gloria M. Ferrell, and Sharon A. Fitzgerald

Subjects
Hydrology, geography, geography.geographical_feature_category, Wastewater, Drainage basin, Environmental science, STREAMS, Orange (colour), Water quality
Published
2014
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17. Tissue polypeptide specific antigen (TPS) in breast cancer—an initial evaluation

Author

Michael J. Kerin, C. J. O’Boyle, H. Grimes, D.M. O'Hanlon, and H.F. Given

Subjects
Oncology, medicine.medical_specialty, Pathology, Tissue Polypeptide Antigen, Breast Neoplasms, Metastasis, Breast Diseases, Breast cancer, Predictive Value of Tests, Recurrence, Internal medicine, Biomarkers, Tumor, Carcinoma, medicine, Humans, Disseminated disease, Prospective Studies, business.industry, General Medicine, medicine.disease, Tumor progression, Disease Progression, Female, Surgery, Breast disease, Neoplasm Recurrence, Local, Peptides, business, Breast carcinoma
Abstract

Tissue Polypeptide Specific-Antigen (TPS), a marker of cell proliferation, was evaluated in 258 patients, 216 with breast carcinoma and 42 with benign breast disease. TPS was measured pre-operatively in 98 patients and correlated with stage of disease showing a progression from Stage I through to Stage IV disease. TPS increased with increasing tumour size, however, TPS levels did not correlate with the number of involved lymph nodes. TPS was measured during follow-up in 118 patients, 64 had no evidence of recurrence, 23 had evidence of loco-regional recurrence and 31 had evidence of metastatic disease. TPS levels were significantly elevated in all categories of recurrence and were highest in patients with disseminated disease. Patients with elevated TPS during follow-up were more likely to experience disease progression on further follow-up. This preliminary study demonstrates that this marker may be useful as an index of tumour burden and deserves further evaluation in a large population to determine whether it can aid in the identification and follow-up of patients with recurrent disease.

Published
1996
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18. Irish Association for Cancer Research

Author

M. Lawler, A. Locasciulli, A. Bacigalupo, P. Humphries, P. Ljungman, S. R. McCann, N. Nolan, E. W. McDermott, J. R. Reynolds, A. McCann, R. Rafferty, P. Sweeney, D. Carney, N. J. O’Higgins, M. J. Duffy, C. Gardiner, D. J. Reen, M. A. O’Connell, D. Kelleher, N. Hall, L. A. J. O’Neill, A. Long, J. V. McCarthy, R. S. Fernandes, T. G. Cotter, E. Ryan, A. Kitching, P. MacMathuna, E. Mulligan, R. Merriman, P. Dervan, P. Kelly, T. F. Gorey, J. R. Lennon, J. Crowe, M. A. Bennett, E. W. Kay, B. Curran, D. P. O’Donoghue, M. Leader, D. T. Croke, J. M. O’Connor, V. J. McKelvey-Martin, P. G. McKenna, J. M. O’Riordan, A. Tobin, M. O’Mahoney, F. M. Keogh, J. O’Riordan, C. McNamara, P. McEneaney, P. A. Daly, M. Farrell, S. Young, D. Gibbons, P. McCarthy, H. Mulcahy, N. A. Parfrey, K. Sheahan, H. Lambkin, C. Mothersill, D. Chin, K. Sheehan, P. Kelehan, N. Parfrey, M. Morrin, F. Khan, P. Delaney, D. M. Rowan, W. J. Orminston, P. P. Donnellan, A. Khalid, M. Kerin, D. M. O’Hanlon, P. Kent, H. F. Given, S. M. Kennedy, G. McGeoch, N. K. Spurr, J. Barrett, G. O’Sullivan, J. K. Collins, T. Willcocks, S. Kennedy, J. Dolan, W. Gallagher, E. McDermott, N. O’Higgins, R. Hagan, R. McManus, W. Ormiston, P. Daly, O. Sheils, M. McDermott, D. S. O’Briain, D. Maher, P. Costello, F. Flanagan, J. Stack, J. Ennis, H. Grimes, A. Yanni, M. Harrison, W. S. Lowry, S. E. H. Russell, R. J. Atkinson, P. White, I. Hickey, D. W. Bell, D. Biggart, J. Doyle, M. J. Staunton, E. F. Gaffney, P. A. Dervan, M. M. McCabe, J. J. Fennelly, D. N. Carney, M. O’Reilly, J. N. McMahon, M. Moriarty, B. Hurson, A. J. O’Neill, H. Magee, J. O’Loughlin, P. Cremin, W. Orminston, J. McCarthy, P. Redmond, S. Duggan, S. Rea, D. Bouchier-Hayes, J. O’Donnell, C. Duggan, J. Crown, D. Bermingham, A. Nugent, C. Fleming, P. Crosby, S. Wolff, D. McCarthy, C. Barry Walsh, M. Cassidy, S. Husain, E. Kay, M. Thornhilll, D. Whelan, D. Barry, M. Turner, W. Prenderville, F. Murphy, W. Prendiville, G. Gibson, T. O’Grady, M. Carmody, J. Donohoe, J. Walshe, G. M. Murphy, J. O’Donoghue, K. Kerin, S. Ahern, K. Molloy, N. Goulden, D. H. Pamphilon, M. O’Connell, C. Power, A. Leroux, M. Perricaudet, D. Walls, F. Britton, L. Brennan, Y. A. Barnett, B. Madden, L. P. G. Wakelin, H. C. Loughrey, P. Corley, H. P. Redmond, R. W. G. Watson, I. Keogh, D. O’Hanlon, S. Walsh, J. Callaghan, M. McNamara, A. Benedict-Smith, C. Barnes, D. Neylon, M. Fenton, M. Searcey, C. M. Topham, L. G. Wakelin, N. M. Howarth, A. Purohit, M. J. Reed, B. V. L. Potter, W. J. Hatton, G. McKerr, D. Harvey, J. Carson, B. M. Hannigan, P. J. McCarthy, S. McClean, B. T. Hill, C. Costelloe, W. A. Denny, B. Fingleton, S. McDonnell, M. Butler, N. Corbally, J. F. Stephens, G. Martin, A. McGirl, E. Lawlor, N. Gardiner, S. Lynch, M. de Arce, F. O’Brien, A. Duggan, S. O’Herlihy, F. Shanahan, G. O’Keeffe, S. McCann, K. Sweeney, A. O. Neill, D. Pamphilon, M. Sheridan, I. Reid, C. B. Seymour, T. Walshe, T. P. Hennessy, A. O’Mahony, J. O’Connell’, C. Lawlor, S. Nolan, D. Morrisey, P. J. Pedlow, M. Walsh, S. W. Lowry, J. J. A. McAleer, S. R. McKeown, M. Afrasiabi, T. R. J. Lappin, B. Joiner, K. V. Hirst, D. G. Hirst, E. Sweeney, J. VanderSpek, J. Murphy, and F. Foss

Subjects
medicine.medical_specialty, Irish, business.industry, Association (object-oriented programming), Family medicine, medicine, language, General Medicine, business, language.human_language
Published
1995
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19. Sylvester O’halloran surgical scientific meeting

Author

F. Malone, Michael J. Duffy, W. A. Tanner, L. Young, Joseph Deasy, T. P. O≿dwyer, F. Flanagan, J. Drumm, R. G. Barclay, P. V. Delaney, J. McCarthy, Terry Boyle, J. A. Thornhill, T. M. Feeley, R. O≿donnel, S. Duggan, P. Sweeney, J. Callahan, G. M. Lennon, D. J. Hehir, J. M. O≿donoghue, F. Graham, H. S. Rogers, M. D. McCaigue, B. Strunz, O. Traynor, F. Jakoubek, H. Naama, P. R. O≿connell, S. J. Sheehan, H. Grimes, T. E. D. Mcdermott, I. Shuaib, M. Barry, Ivan Keogh, C. Campbell, Enda W. McDermott, P. Burke, R. O≿sullivan, Henry Paul Redmond, G. O. Sullivan, H. Mcloughlin, P. Horgan, P. A. Grace, T. Gorey, Seamus Morris, P. Broe, John Russell, M. A. Stokes, J. G. Johnston, Mary-Paula Colgan, M. I. Halliday, Q. Y. Ma, F. Loughnane, G. D. Magee, D. Kelly, J. Shou, Frank B. V. Keane, Jill J. F. Belch, F. Khan, D. O≿hanlon, T. Nyhan, A. Hennessy, P. W. Eustace, S. K. Al-Ghazal, H. F. Given, David Mulvin, P. J. Meagher, B. J. Rowlands, C. B. O. Suilleabhain, S. Baldota, J. Ennis, C. Waters, I. M. Halliday, M. D. Morasch, P. Madhavan, David Bouchier-Hayes, R. I. Holdsworth, M. Ahearne, H. Abdih, S. Dolan, P. Gillen, Alfred E. Wood, John M. Fitzpatrick, R. Vashisht, M. Akram, J. A. McKeever, D. Bouchier Hayes, C. J. Kelly, K. Stokes, P. Mohan, G. Mccluggage, John Hyland, T. Creagh, S. Reid, L. S. Young, C. Malone, N. Barrett, Hannah McGee, G. R. Campbell, R. B. Stephens, M.J. Kerin, Oliver J. McAnena, G. N. Collins, M. R. Butler, J. Dolan, T. Carroll, M. P. Brady, D. Waldron, Denis Evoy, A. R. Mundy, T. V. Keaveny, S. E. A. Attwood, M. Koppikar, P. Neary, Michael Walsh, P. Kent, K. S. Cross, W. D. B. Clements, B. Bulle, N. F. Couse, N. Williams, J. M. Fitzpatrick, C. O≿herlihy, D. Maher, M. C. Regan, J. K. Lyerly, John R. Kelly, B. Boyle, G. D. Shanik, K. F. McGeeney, Thomas F. Gorey, Conor Patrick Delaney, M. Durkan, Dermot J. Moore, J. H. Wang, Stewart R. Walsh, W. P. Joyce, R. Waldron, G. Lynch, R. Grainger, T. Smalley, C. A. O. Boyle, D. Mehigan, D. Mcavinchey, J. K. Collins, W. Norwood, J. A. O≿donnell, P. Mccarthy, J. Russell, N. H. Anderson, V. S. Donnelly, J. O≿donnell, P. M. Mercer, R. W. G. Watson, Peter T. McCollum, C. P. Delaney, S. Brown, J. Barrett, S. W. Macgowan, S. Kennedy, T. Hall, N. J. O≿higgins, D. M. O≿hanlon, D. Chin, Peter A. Stonebridge, M. Morrin, John M. Daly, J. Mccann, H. Gallagher, and J. Egan

Subjects
business.industry, Medicine, Art history, General Medicine, business
Published
1994
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20. National Scientific Medical Meeting 1994 Abstracts

Author

M. J. Turner, J. Upton, T. P. J. Hennessy, P. Kelehan, A. D. Crockard, Paul A. McGettigan, M. Grouden, Y. A. Cusack, Catherine Curran, B. Cryan, C. Pidgeon, T. G. Cooke, E. Shorten, B. M. Kinsella, P. Sweeney, A. Southey, S. G. Richardson, M. Sheehan, E. R. Horwitz, J. Belch, E. Griffin, E. Healy, A. Oakhill, H. Johnson, P. Shah, A. Kinsella, P. A O’Connell, P. Humphries, P. Lenehan, S. Fanning, C. N. Pidgeon, D. Pamphilon, M. T. P. Caldwell, B. Tuohy, P. Dack, J. Murphy, P. Gaffney, Fiona M. Stevens, C. Bergin, A. Locasciulli, G. Nolan, M. Kearns, D. F. Smith, J. P. H. Fee, I. Reid, Muiris X. Fitzgerald, T. Cawley, G. Swanwick, U. Kondaveeti, F. Davidson, A. Early, D. Noone, S. Farrell, A. Hale, C. M. Costello, L. English, Colm O'Herlihy, B. Crowley, J. F. Lyons, P. Kent, D. Coakley, M. Geary, L. J. Egan, M. Hogan, G. A. FitzGerald, P. White, R. Merriman, Mary Leader, M. Fitzgerald, N. AlAnsari, H. P. Singh, N. Mahmud, Sarah Rogers, T. Conlon, J. O’Shea, C. Larkin, Norman Delanty, L. Maguire, J. Mahady, J. T. Ennis, E. Creamer, R. P. Kernan, I. Temperley, M. Hargrove, J. Joseph Walshe, J. M. T. Redmond, B. Gilmer, Michael Hutchinson, J. Woof, K. D. Carson, C. Darby, D. Lyons, Michael T. Dawson, G. Gibson, A. B. Atkinson, J. A. Lawson, N. Ryall, D. S. O’Briain, R. Pilkington, W. Blunnie, T. Donoghue, D. M. O’Hanlon, S. Coulter-Smith, James R. Docherty, G. Mortimer, Enda W. McDermott, C. Conlon, T. Cooke, B. Hennelly, P. Boylan, P. Lawlor, S. Young, B. Marsh, R. J. Cunney, S. Lynch, W. O’Connor, M. C. Prabhakar, G. Dempsey, C. Fitzpatrick, L. Boissel, P. O’Callaghan, Terry J. Smith, B. P. McMahon, F. M. Ryan, D. Allcut, Sinead O’Neill, Emer Shelley, M. Coca-Prados, J. Lawson, E. G. Smyth, J. Geraghty, C. A. Whelan, M. Goggins, R.J. Cunney, B. McGeeney, A. J. Cunningham, P. Eustace, K. Carson, B. Sheridan, D. Powell, C. Foley-Nolan, P. M. Byrne, L. Barnes, G. King, C. Cullen, Maria A. O'Connell, Shaun Gallagher, G. J. Fitzpatrick, J. Mulhall, M. G. Mott, E. Shanahan, S. Murphy, D. Buggy, Cliona O'Farrelly, M. Buckley, T. M. Murray, G. McQuoid, D. O’Riordain, P. M. Bell, P. McNamara, P. Byrne, M. P. Colgan, S. Hone, T. J. McKenna, R. McManus, D. O’Neill, M. R. N. Darling, Aaj Adgey, P. Campbell, T. Finch, M. Robson, H. C. Loughrey, P. Foster, C. O’Keane, G. I. Adebayo, J. McEnri, J. D. Allen, Martin Cormican, C. Timon, E. O’Mongain, V. S. Donnelly, E. Corcoran, J. J. Gilmartin, M.J. Duffy, Brian J. Harvey, Peter P.A. Smyth, J. O. L DeLancey, Desmond J. Fitzgerald, J. Wang, T. Larkin, C. Barry-Kinsella, T. O’Connell, E. O’Callaghan, A Jefferson, G. D. Johnston, N. Shepard, A. L. Kennedy, I. M. Rea, C. F. McCarthy, D. Kerr, Margaret McLaren, G. Z. Kaminski, Hugh Staunton, P. Grainger, M. Norton, F. Lavin, B. F. McAdam, M. Maguire, R. Rafferty, M. Caldwell, R. Hone, C. M. MacDonagh-White, Dermot Kelleher, R. Namushi, G. MacKenzie, Michael J. Kerin, James Bernard Walsh, Mark Lawler, A. K. Cherukuri, U. Fearon, M. Doran, S. Orwa, J. Liu, N. Al fnAnsari, A. P. Heaney, K. Tipton, M. Glennon, H. Grimes, S. Hamilton, C. Smith, C. M. Kilgallen, Thomas Barry, R. Horgan, C. Saidtéar, V. Urbach, A. B. P. Cullinane, M. A. Christie, K. Daly, L. Madrigal, D. R. Hadden, C. McCreary, Q. Razza, Catherine Hayes, T. Walsh, T. Clarke, E. T. Burke, S. Liston, D. Mulherin, M. P. Reilly, D. Tansey, N. Cannon, V. P. Coffey, A. A. El-Magbri, D. P. O’Donoghue, P. W. N. Keeling, Jack Phillips, L. Condren, Jill J. F. Belch, J. R. Anderson, B. McAdam, Reza Mofidi, F. Hegarty, J. Kavanagh, Frances J. Hayes, D. Murray, E. Holmes, J. Fenton, J. Strattan, G. D. Wright, D. H. Hill, H. G. Nelson, A. C. Moloney, J. Goh, C. S. McArdle, G. Loughrey, J. Phillips, J. Fennell, T. Aherne, J. Stronge, S. Lewis, Kieran Sheahan, T. Markham, Madeline Murphy, P. J. Byrne, B. Harding, R. Hitchcock, M. Bourke, J. McSweeney, K. Colgan, Z. Johnson, D. Cotter, R. F. Harrison, Patricia Fitzpatrick, J. Feely, J. Crowe, H. F. Given, A. Mofidi, M. Hynes, E. B. McNamara, Michael J. Turner, T. Woods, Blánaid Hayes, J. Tyrrell, E. O’Toole, G. G. Lavery, A. M. Deveney, A. J. McShane, O. Bradley, B. Blackwood, O. White, L. W. Poulter, H. Maguire, E. S. Prosser, N. Dowd, Michael Kennedy, Peter J. Kelly, John J. O'Leary, K. Hickey, B. C. Morrow, P. Oslizlok, Malachi J. McKenna, J. Fabry, R. Chander, D. Clarke, C. O’Sullivan, M. O’Reilly, M. M. Young, F. Abuaisha, Clare O'Connor, N. A. Herity, J. Toland, D. Buckley, G. Kirk, E. Maguire, Cecily Kelleher, I. Hillary, H. D. Alexander, R. Keimowitz, L. H. Murray, S. Hennessy, D. Whyte, K. Holmes, M. S. Robson, J. Stratton, Conor T. Keane, B. Kanagaratnam, A. Heffernan, J. Golden, Anthony O'Grady, A. Tobin, J. I. O’Riordan, D. Sloan, Niall O'Higgins, A. Vance, A. Foot, B. Murphy, F. Mulvany, P. C. Sham, J. Higgins, P. M. Mercer, G. Browne, Y. Young, H. J. Gallagher, Thomas F. Gorey, A. Lane, Nollaig A. Parfrey, P. R. O’Connell, J. O’Neill, J. Adgey, Z. Imam, R. O’Sullivan, D. Maguire, L. Thornton, L. Drury, Douglas J. Veale, M. Reilly, M. Eljamel, A. W. Murphy, J. Laundon, M. Reidy, E. Ryan, A. Bacigalupo, C. O’Shaughnessy, B. Silke, R. A. Greene, J. P. McGrath, Connail McCrory, C. T. Keane, S. McMechan, J. Strangeways, T. O’Gorman, Malcolm D. Smith, M. Madden, G. Nicholson, B. O’Shea, A. McCann, M. Foley, G. Gearty, J. Hosseini, R. O’Moore, A. Taylor, A. M. Hetherton, Elizabeth Smyth, John V. Reynolds, J. A. B. Keogh, John Bonnar, D. Cafferty, D. Graham, J. R. Lennon, Barry Bresnihan, B. Denham, R. Holliman, M. B. O’Connor, Y. K. Tay, Padraic MacMathuna, M. S. Eljamel, H. Osborne, G. Shanik, S. M. Lavelle, R. Watson, Premkumar, M. Byrne, Fionnuala M. McAuliffe, S. Sharif, S. Killalea, E. Zimmermann, K. Kengasu, D. Duff, A. Hickey, D. McShane, J. Fogarty, M. Geoghegan, G. O’Reilly, T. Scott, P. Killeen, T. Kinsella, E. McIlrath, Helen M. Byrne, M. Borton, R. A. Rusk, J. M. McGinley, P. L. Yeoh, D. Warde, R. Stanwell-Smith, John Newell, M. Greer, David J. Brayden, E. M. Lavelle, C. D’Arrigo, J. McManus, R. Gonsalves, Barbara Murray, P. Murphy, G. D’Arcy, Camillus K. Power, N. Hughes, P. M. E. McCormack, R. Dwyer, N. Iman, R. B. Fitzsimons, S. C. Sharma, M. Carmody, Stewart R. Walsh, Gillian M. Murphy, E. McGuinness, L. Kevin, E. Barrett, S. K. Cunningham, A. Orren, S. Ni Scanaill, Karl Gaffney, P. McCormack, M. Martin, J. Malone, E. L. Egan, M. J. Walshe, D. Walsh, S. Kaf Al-Ghazal, M. Kuliszewski, S. Blankson, J. R. Sutherst, M. Lynch, M. T. Thornton, I. Boylan, Fiona Mulcahy, Oliver FitzGerald, T. N. Walsh, Y. Wen, K. McQuaid, D. R. McCance, M. Hall, U. Ni Riain, J. Hollyer, Michael Walsh, J. Donohoe, J. Doherty, D. Carney, D. J. Moore, S. E. Lawlor, K. Birthistle, H. S. Khoo Tan, A. M. Powell, G. Boyle, C. Burke, D. Veale, E. Lawlor, L. Zimmerman, M. Stewart, L. Hemeryck, Conor Burke, Irene B. Hillary, A. Pooransingh, K. Butler, P. W. Johnston, Daniel Rawluk, N. Foreman, M. J. Conran, B. L. Sheppard, P. Gilligan, D. Keane, E. Mulligan, D. Phelan, J. G. Kelly, J. Stack, Y. McBrinn, E. Sweeney, S. Calvert, E. A. Maguire, E. Keane, D. McKeogh, M. Post, S. N. Tham, P. Connolly, A. C. Gordon, Frank Gannon, Rosemarie Freaney, C. Collins, J. F. Malone, B. Moule, C. Saidlear, Seamus Sreenan, S. Teahan, J. McCann, J. Dixon, C. Quigley, J. L. Waddington, D. Maher, I. Graham, Diarmaid Hughes, S. Thomas, A. O’Leary, K. Carroll, A. M. Bourke, J. Candal Couto, N. Nolan, R. Harper, D. P. O’Brien, T. C. M. Morris, E. O’Leary, Michael M. Maher, M. White, C. Hallahan, N. Ni Scannlain, Colm O'Morain, E. Hayes, Luke Clancy, B. Stuart, P. Crean, J. Dowling, I. Cree, M. A. Heneghan, B. Cassidy, C. A. Barnes, Donald G. Weir, J. Flynn, E. Clarke, J. Stinson, N. Gardiner, R. Mulcahy, B. J. Harvey, Gerald C. O'Sullivan, G. S. A. McDonald, P. Costigan, P. O’Connor, D. Carrington, J. Goulding, C. Sheehan, A. Kitching, Conleth Feighery, M. LaFoy, E. Coleman, S. Pathmakanthan, C. Condon, S. B. Grimes, J. M. O’Donoghue, J. Hildebrand, Gerard Bury, A. W. Clare, S. Feely, S. R. McCann, J. A. O’Hare, B. E. Kelly, A. Moloney, M. Donnelly, D. O’Meara, and A. Chan

Subjects
medicine.medical_specialty, business.industry, Family medicine, Human immunodeficiency virus (HIV), Medicine, General Medicine, business, medicine.disease_cause
Published
1994
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21. 19th Sir peter freyer memorial lecture and surgical symposium 16th and 17th September 1994

Author

D. A. McEvoy, B. Connolly, V. Donohue, D. O’Halpin, H. Rowley, T. P. O’Dywer, C. Timon, J. A. McKeever, M. A. Stokes, J. G. Bannigan, M. J. Early, D. M. Baker, Van-Tam Nguyen, D. Bush, J. Jones, J. B. Bourke, K. S. Cross, G. Durkan, M. Stokes, T. Carroll, T. Gorey, K. O’Malley, D. Mulcahy, D. McCormack, J. McElwain, S. C. Natin, T. N. Walsh, T. P. J. Hennessy, K. Carson, R. Page, W. Blunnie, D. C. Moriarty, R. W. G. Watson, D. M. Bouchier-Hayes, H. Abdih, C. J. Kelly, M. Barry, P. Burke, A. Tanner, D. J. Bouchier-Hayes, T. O’Sullivan, A. F. Horgan, D. H. L. Chin, J. A. Mannick, M. L. Rodrick, N. Finnegan, S. T. O’Sullivan, S. F. Wolf, M. C. Barry, C. Condron, R. G. K. Watson, J. D. Evans, C. A. Maxwell-Armstrong, M. K. Barry, K. K. Singh, P. Ralston, C. D. Auld, M. Henderson, J. McCormick, A. D. F. Walls, I. Keogh, M. Kerin, D. O’Hanlon, S. Walsh, P. Kent, J. Callaghan, H. F. Given, P. Madhavan, B. Golden, F. Khan, E. Murphy, N. Couse, G. Burke, P. V. Delaney, R. McLoughlin, P. Kenny, D . O’Hanlon, H. Grimes, S. Reid, P. Neary, M. Nassralla, T. K. Neelamekam, P. Horgan, O. Traynor, P. G. Horgan, J. Hyland, D. M. O’Hanlon, C. O’Boyle, M. J. Duffy, E. W. M. McDermott, D. Reilly, J. J. Fennelly, N. J. O’Higgins, A. McNamara, H. Mullett, D. O’Riordan, E. McDermott, M. Sharp, N. O’Higgins, M. Murphy, M. Little, D. Maher, A. Khalid, P. McCarthy, I. F. Given, C. Bolger, J. P. Phillips, C. Gilligan, S. Zareb, C. Roake, D. S. O’Riordain, D. Farley, C. Grant, J. van Heerden, D. P. O’Brien, M. J. Flynn, F. B. V. Keane, B. Sweeney, D. O’Riordain, A. J. Curran, W. Joyce, D. Smith, H. Gallagher, M. A. Walsh, D. Bouchier-Hayes, J. Phillips, T. O’Brien, S. W. Yusuf, A. C. Perkins, M. Frier, P. W. Wenham, B. R. Hopkinson, G. S. Makin, R. Hind, W. Yusuf, S. C. Whitaker, R. E. Hind, T. A. M. Chuter, G. C. Durkan, M. J. Grenell, M. C. Regan, T. F. Gorey, C. F. Castineira, S. J. Sheehan, M. Wali, M. P. Colgan, D. J. Moore, G. D. Shanik, G. McGreal, J. Kelly, D. Hehir, M. P. Brady, D. M. Sibbering, P. A. M. Holland, A. R. M. Wilson, R. W. Blarney, M. Khurrum Baig, N. Mulligan, B. Farrell, F. O. Cunningham, M. Magd-Eldin, P. Keeling, Y. A. Gul, S. W. Yeo, U. D. Khan, F. Lennon, M. F. Shine, V. Kalidasan, O. Fulena, E. J. Guiney, R. J. Fitzgerald, M. Corbally, A. E. Wood, C. M. Reardon, G. T. McGreal, D. J. Hehir, J. A. O’Donnell, W. O. Kirwan, A. A. Mahomed, A. Keshgar, R. Surna, M. T. Corbally, S. O’Rourke, I. Beckingham, M. C. Bishop, J. Husain, N. Hegarty, J. Calleary, I. Rafi, M. Gilmore, S. M. Saleem, H. P. Singh, T. Aherne, H. P. Redmond, J. McCarthy, D. M. Mulcahy, P. Nicholson, P. Harrington, T. Sharif, H. Smyth, G. Fenelon, J. Pegum, J. Corrigan, A. Jenkinson, A. A. El-Magbri, M. A. Gussail, M. A. Smew, A. Martin, M. Bennett, M. A. Farrell, C. Curran, M. J. Kerin, M. T. P. Caldwell, P. J. Byrne, S. Duggan, A. S. Jones, J. K. Field, D. Monaghan, C. Condren, S. Crerand, M. Kavanagh, P. Dervan, B. Hurson, K. Aiyaswami, D. Evoy, M. Walsh, B. Garrihy, S. Kaf Al-Ghazal, J. O’Donoghue, J. McCann, S. Wagstaff, C. Conroy, M. Dolan, L. Smith, L. Klenerman, J. Noel, V. Waide, D. O’Sullivan, C. Biyani, C. Powell, M. Heal, R. Surana, A. Khan, T. Lynch, T. Sami, W. Baluch, D. Hickey, M. Donovan, P. McLean, D. Murphy, S. Johnston, V. Rastogi, J. Doyle, J. R. Flynn, P. Kelly, M. F. Neligan, S. W. MacGowan, O. Sharkey, A. Bhojwani, C. Barry Walsh, E. Kay, C. Milbum, M. Leader, J. McDermott, D. Moriarty, P. Caushaj, J. M. Fitzpatrick, D. Byrne, W. P. Hederman, N. K. O’Malley, K. H. Chan, P. Fleming, G. C. O’Sullivan, K. Aizaz, A. F. O’Donnell, D. A. Luke, E. M. McGovern, N. Patil, P. Gormley, and P. M. McCarthy

Subjects
medicine.medical_specialty, business.industry, medicine, Physiology, Medical physics, General Medicine, Session (computer science), business
Published
1994
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22. Simple method for comparing reliability of two serum tumour markers in breast carcinoma

Author

R Skehill, H Grimes, H F Given, D P O'Brien, and D. B. Gough

Subjects
CA15-3, Metastatic breast, medicine.medical_specialty, Pathology, ca15-3, monoclonal-antibodies, Mammary gland, mca, Breast Neoplasms, Sensitivity and Specificity, Gastroenterology, Pathology and Forensic Medicine, Antigens, Neoplasm, Internal medicine, Biomarkers, Tumor, medicine, Carcinoma, Humans, Cutoff, Antigens, Tumor-Associated, Carbohydrate, False Positive Reactions, Neoplasm Metastasis, disease, Receiver operating characteristic, Epithelioma, business.industry, carcinoembryonic antigen, General Medicine, medicine.disease, medicine.anatomical_structure, ROC Curve, Female, cancer patients, Breast carcinoma, business, Research Article
Abstract

AIMS--To compare the two breast tumour markers, CA15-3 and mucinous-like carcinoma associated antigen (MCA), using Receiver Operating Characteristic (ROC) curve analysis. METHODS--One hundred and ninety six patients "presenting" with breast carcinoma had serum CA15-3 and MCA concentrations measured. RESULTS--Using these markers as indicators of stage IV disease at the recommended laboratory level, true positive rates (TPR) and false positive rates (FPR) were obtained as follows: CA15-3 TPR = 75%, FPR = 7.4%, MCA TPR = 80%, FPR = 59.1%. By increasing the CA15-3 cutoff level to 45 U/ml, a TPR and FPR of 75% and 0.6%, respectively were obtained. By increasing the MCA cutoff level to 23 U/ml, a TPR and FPR of 65% and 2.3%, respectively, were obtained. CONCLUSIONS--Using ROC curve analysis shows that CA15-3 is a superior indicator of metastatic breast disease than MCA at recommended laboratory levels, and by altering the cutoff points, the specificity and sensitivity for both these markers can be improved.

Published
1994
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23. Irish cardiac society

Author

D. Sugrue, S. Leavey, C. Daly, Peter Crean, H. O'Kane, O'Donnell, Victor A. Umans, J. Gibson, P. W. Johnston, J. D. Laird, D. Gladstone, J. McComb, H. C. Mulholland, T. M. Higgins, M. J. Clarkson, A. Mannion, N. P. S. Campbell, R. Sheahan, R. Power, J. J. Crowey, Benno J. Rensing, R. W.F. Campbell, Barry Bresnihan, S. E. Abrams, P. C. Gillette, F. Mulcahy, J. H. Horgan, J. Adgey, A. B. Bridges, Ian D. Graham, S. W. Webb, B. G. Craig, J. D. Allen, J. McGinley, S. McKiernan, H. Bain, David P. Foley, Carol M. Wilson, P. J. Freyne, I. Temperley, P. Shah, Cormac McCarthy, R. Refsum, F. Lavin, P. de Jaegere, T. Graham, M. Keane, Margaret McLaren, A. Hennesy, G. P. Mcneill, W. Fennell, K. S. Tan, M. J. Tobin, L. Blair, J. Finn, T. Gumbrielle, T. Kinsella, P. J. Quigley, J. P. Herman, F. Chappuis, C. Wilson, J. Galvin, Mary B. Codd, D. B. O'Keeffe, J. R.L. Hamilton, S. O’Mahony, A. J. McNeil, P. Crowe, M. Ryan, B. O’Murchu, Stuart A. Lewis, F. Coakley, Barbara J. Knick, T. J. McMurray, G. Gearty, A. Forde, L. P.N. Henry, C. Cullen, Bernard J. Gersh, Hickey N, A. Simpson, R. Ferguson, F. A. Casey, G. Geary, C. Pye, D. Cochrane, M. M. Khan, E. McGovern, Hannah McGee, C. Collins, T. H. Pringle, William Wijns, K. P. Walsh, P. A. Joseph, R. ulcahy, P. J. De Feyter, J. Hurley, L. Daly, S. R. Vallely, K. Robinson, F. Fennell, M. Lonergan, D. J. Coehrane, J. Anderson, N. Rooney, J. O'Sullivan, J. Cleland, Patricia M. Kearney, B. M. McClements, R. Clarke, John P. Bourke, H. Grimes, L. O'Sullivan, Wolfgang Rutsch, C. Austin, B. Crowe, K. Daly, S. M. Donnelly, Walter R.M. Hermans, C. M. McDaid, Jill J. F. Belch, P. A. Sullivan, P. W. Serruys, C. L. Case, M. Neligan, Frank Gannon, G. Dempsey, Aaj Adgey, P. P. Kearney, D. J. McEneaney, A. J. Stewart, Jeroen Vos, N. Danchin, C. Wren, C. J. Hilton, B. McAdam, Gilbert MacKenzie, N. El Gaylani, David R. Holmes, N. McCabe, G. King, S. Duff, A. Hasan, J. H. Dark, K. M.P. Carroll, A. S. Phillips, P. C. Oslizlok, Oliver FitzGerald, K. R. Bailey, Javier Escaned, E. Shelley, B. Maurer, S. Hunter, P. Ueland, D. McEneaney, M. Diamond, Michael Walsh, and H. Emanuelsson

Subjects
Irish, business.industry, language, Medicine, General Medicine, Ancient history, business, language.human_language
Published
1993
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26. Irish society of gastroenterology

Author

A. Brannigan, N. N. Williams, M. Grahn, N. S. Williams, J. M. Fitzpatrick, P. R. O’Connell, C. V. Soong, P. Blair, M. I. Halliday, J. M. Hood, B. J. Rowlands, A. A. B. Barros D’sa, R. J. Cahill, S. Beattie, H. Hamilton, C. O’Morain, S. J. Kelly, K. E. O’Malley, W. A. Stack, D. O’Donoghue, A. W. Baird, K. J. Cronin, M. J. Kerin, J. Crowe, P. MacMathuna, J. Lennon, T. F. Gorey, A. Chua, V. O’Kane, T. G. Dinan, P. W. N. Keeling, E. Mulligan, K. L. Cronin, P. Dervan, A. Ireland, D. Murphy, G. O’Sullivan, E. Ryan, P. Kelly, J. Gilvarry, S. Sant, X. J. Fan, C. N. Shahi, M. O’Connell, D. G. Weir, D. Kelleher, J. McDevitt, J. M. O’Donoghue, P. G. Horgan, W. J. Byrne, M. McGuire, H. F. Given, M. A. Daw, P. Kavanagh, P. O’Mahony, T. Joy, F. Gleeson, A. Mullan, M. Gibney, Anne Mannion, F. M. Stevens, C. F. McCarthy, A. A. Killeen, P. M. Murchan, J. V. Reynolds, N. Leonard, P. Marks, F. B. V. Keane, W. A. Tanner, M. A. O’Connell, B. Corridan, R. Collins, R. Shannon, R. Cahill, W. P. Joyce, M. Goggin, J. Hyland, O. Traynor, A. Qureshi, M. DaCosta, N. Brindley, P. Burke, P. Grace, D. Bouchier-Hayes, A. L. Leahy, G. Courtney, H. Osbome, N. O’Donovan, M. O’Donoghue, J. K. Collins, D. Morrissey, J. E. McCarthy, H. P. Redmond, A. D. K. Hill, P. A. Grace, H. Naama, O. M. Austin, D. M. Bouchier-Hayes, J. M. Daly, D. Breslin, C. P. Delaney, S. T. O’Sullivan, G. C. O’Sullivan, W. O. Kirwan, C. D. Weir, L. T. McGrath, S. Maynard, N. H. Anderson, C. Gokulan, T. A. O’Gorman, E. Breshihan, Pin Yin Lam, R. Skehill, H. Grimes, J. A. McKeever, M. A. Stokes, D. Mehigan, T. V. Keaveny, J. Meehan, A. Molloy, C. Q’Farrelly, J. Scott, M. S. Dudeney, A. Leahy, P. A. Grace., G. McEntee, N. D. Hcaton, V. Douglas, R. Mondragon, J. O’Grady, R. Williams, K. C. Tan, H. X. Xia, C. T. Keane, C. A. O’Morain, A. O’Mahony, A. Corbett, P. Harte, H. Mulcahy, S. Patchett, W. Stack, M. Gallagher, K. Connolly, J. Doyle, J. R. Flynn, M. Maher, D. Hehir, A. Horgan, R. Stuart, M. P. Brady, P. W. Johnston, B. T. Johnston, B. J. Collins, J. S. A. Collins, A. H. G. Love, S. G. Marshall, T. G. Parks, R. A. J. Spence, H. J. O’Connor, K. Cunnane, M. Duggan, P. MacMalhuna, M. Kerin, S. E. A. Attwood, L. Viani, M. Jeffers, T. N. Walsh, P. J. Byrne, I. Frazer, T. P. J. Hennessy, G. L. Hill, W. Dickey, S. A. McMillan, C. Bharucha, K. G. Porter, H. Rolfe, J. Thornton, J. Coleman, R. B. Stephens, S. Hone, K. Holmes, I. P. Kelly, T. P. Corrigan, D. McCrory, M. McCaigue, G. R. Barclay, M. Quirke, J. E. Hegarty, D. P. O’Donoghue, D. O’Hanlon, and J. Byrne

Subjects
medicine.medical_specialty, Irish, business.industry, Ophthalmology, language, Medicine, Library science, General Medicine, business, language.human_language
Published
1992
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27. Sixteenth sir peter freyer memorial lecture and surgical symposium September 13th & 14th, 1991 Session I

Author

J. Coulter, R. G. Molloy, K. T. Moran, R. Waldron, W. O. Kirwan, C. O’Suilleabhain, A. Horgan, K. Mealy, P. Burke, J. Hyland, A. F. Horgan, M. Sheehan, R. M. Browne, O. Austin, A. P. Clery, J. M. Deasy, S. Sulaiman-Shoaib, J. Soeda, D. S. O’Briain, P. Puri, E. C. Coveney, V. McAllister, E. W. M. McDermott, N. J. O’Higgins, M. Maher, M. T. P. Caldwell, P. Murchan, W. Beesley, T. M. Feeley, W. A. Tanner, F. B. V. Keane, F. Abbasakoor, S. E. A. Attwood, L P. McGrath, R. B. Stephens, E. O’Broin, M. G. Davies, J. McGinley, C. Mannion, S. Gupta, M. F. Shine, F. Lennon, G. Ninan, R. J. Fitzgerald, E. J. Guiney, B. O’Donnell, A. F. O’Donnell, D. Luke, A. E. Wood, P. G. Murphy, T. N. Walsh, A. D. K. Hill, H. Li, T. P. J. Hennessy, N. Noonan, B. Breslin, P. W. N. Keeling, A. J. Curran, D. B. Gough, I. R. Davidson, P. Keeling, D. P. O’Leary, A. Smythe, N. C. Bird, A. G. Johnson, P. Nicholson, O. Traynor, K. Dawson, J. Aitken, B. A. Cooke, S. P. Parbhoo, N. N.Williams, J. M. Daly, M. Herlyn, D. Bouchier-Hayes, R. C. Stuart, M. J. Allen, W. D. Thompson, A. L. G. Peel, D. T. Hehir, K. Cronin, A. McCann, P. A. Dervan, S. J. Heffernan, W. P. Hederman, M. H. Galea, B. Dilks, A. Gilmour, L. O. Ellis, C. W. Elston, R. W. Blarney, S. O’Rourke, A. Mookens, R. Carter, D. Parkin, N. F. Couse, C. P. Delaney, P. G. Horgan, J. M. Fitzpatrick, T. F. Gorey, J. M. O’Byrne, J. P. McCabe, M. Stephens, F. McManus, J. L.Mangan, D. A. Barr, G. J. Mulvenna, P. Maginn, W. G. Kernohan, R. A. B. Mollan, S. J. O’Flanagan, J. P. Stack, P. Dervan, B. Hurson, S. Tierney, P. Fitzgerald, T. O’Sullivan, P. Grace, J. P. Wyatt, R. J. Evans, S. P. Cusack, S. McGowan, E. McGovem, S. D. Schwaitzberg, R. J. Connolly, R. P. Sullivan, G. Mortimer, J. G. Geraghty, P. J. O’Dwyer, B. S. McGlone, D. P. O’Brien, H. A. Younis, H. F. Given, C. Phelan, J. Byrne, K. Barry, D. Gough, L. Hanrahan, F. Given, J. P. Sweeney, A. M. Korebrits, J. V Reynolds, T. F Gorey, D. M. O’Hanlon, M. A. Stokes, H. P. Redmond, J. McCarthy, P. Losty, M. Murphy, P. E. M. Butler, P. G. Grace, J. R. Novell, S. K. Hobbs, O. Smith, G. Hazlehurst, B. Brozovic, K. Rolles, A. Burroughs, S. Mallett, A. Mehta, D. Buckley, D. Waldron, D. O’Brien, C. Curran, L. Grey, A. Leahy, A. Darzi, D. Leader, P. Broe, J. G. Geoghegan, C. A. Cheng, D. C. Lawson, T. N. Pappas, D. O’Sullivan, M. M. Lieber, T. V Colby, D. M. Barrett, E. Rogers, J. Greally, H. C. Bredin, M. O. Corcoran, M. Kenny, P. Horgan, D. Headon, A. Grace, P. A. Grace, S. Cross, D. Hehir, S. O’Briain, P. Hartigan, M. P. Colgan, D. Moore, G. Shanik, S. Z. Zaidi, D. J. Hehir, K. S. Cross, D. J. Moore, D. G. Shanik, P. Lacy, J. E. Coleman, C. S. McEnroe, J. A. Gelfand, T. F. O’Donnell, A. D. Callow, D. J. Buckley, D. S. O’Riordain, J. A. O’Donnell, P. Meagher, K. Boos, P. Gillen, T. Corrigan, R. Vashisht, M. Sian, E. J Sharp, M. K. O’Malley, M. J. Kerin, D. Wilkinson, A. Parkin, R. C. Kester, M. M. Maher, R. P. Waldron, D. J. Waldron, M. P. Brady, M. Allen, T. H Lyncy, B. Waymont, L. Emtage, G. R. Blackledge, M. A. Hughes, D. M. A. Wallace, L. Mynderse, H. Grimes, F. Chambers, D. Lowe, B. Prasad, D. C. O’Sullivan, M. Barry P. Gillen, M. McNicholas, H. Bredin, T. H. O’Dowd, M. Corcoran, J. M. O’Donoghue, M. McGuire, A. McNamara, T. Creagh, R. Grainger, T. B. D. McDermott, M. R. Butler, M. Gleeson, T. E. D. McDermott, J. P. Hurley, R. Hone, M. Neligan, J. Hurley, M. White, P. McDonagh, D. Phelan, E. McGovern, F. Quinn, F. Breatnach, A. O’Meara, J. P. McGrath, S. R. McCann, E. F. Gaffney, A Hennessy, M. Leader, F. S. Taleb, M. V. McKiernan, P. J. Leyden, J. J. McCann, J. Coleman, A. Quereshi, N. Ajayi, G. McEntee, H. Osborne, D. J. Bouchier-Hayes, S. Johnston, K. O’Malley, E. Smyth, D. L Bouchier-Hayes, P. R. O’Connell, T. Gorey, O. J. McAnena, M. W. Reed, J. L. Duncan, C. S. Reilly, C. McGibney, P. Lawlor, B. Lawless, E. McGuinness, and S. Leahy

Subjects
business.industry, Medicine, General Medicine, Session (computer science), business, Classics
Published
1992
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28. Endometrial response in oestrogenised postmenopausal women after treatment with oral progesterone: results of a prospective analysis

Author

E. M. O'dwyer, G. Mortimer, I. I. Bolaji, and H. Grimes

Subjects
Gynecology, medicine.medical_specialty, Postmenopausal women, business.industry, Low dose, Hormone replacement, Obstetrics and Gynecology, Physiology, Endometrium, Fixed dose, Prospective analysis, medicine.anatomical_structure, medicine, Progesterone treatment, business, After treatment
Abstract

SummaryIn an open, non-comparative, prospective 12 month trial of continuous oestrogen treatment, with the addition of low dose micronised oral progesterone for the first 23 days of each calendar month, endometrial biopsies were obtained from postmenopausal women (n = 40) before treatment, and during the 6th and 12th months of treatment in the late progesterone phase of the cycle (day 20–23), for histopathological analysis.The low fixed dose progesterone administered for 23 days each month resulted in endometrial atrophy in the majority of patients and produced suboptimal progestational effects in others but was not associated with any serious hyperstimulation. This result contradicts the hypothesis that duration of progesterone treatment is more important than the dose in protecting the endometrium in hormone replacement treatment. Both the dose and duration of progesterone administration are important in protecting oestrogenised endometrium.

Published
1992
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29. Irish Endocrine Society

Author

E. Barrett, T. J. McKenna, B. Sheridan, D. R. Hadden, D. G. Barry, D. Brennan, T. M. Fiad, R. Firth, A. I. Traub, G. H. Tomkin, D. P. Rooney, J. G. Jenkins, B. Wade, J. Golden, H. Grimes, F. P. Dunne, A. Johnson, J. C. Stinson, E. Trimble, E. R. Trimble, D. J. Carson, A. M. Hetherton, P. Scanlan, H. M. Whitehead, J. O’Hare, D. R. McCance, P. Dervan, H. Leslie, R. Ryan, R. Skehill, J. A. McKnight, D. Murphy, Y. O’Connell, T. Corrigan, D. Powell, A. L. Kennedy, A. B. Atkinson, N. C. Nevin, A. Smith, C. O. Herlihy, K. Ennis, Peter P.A. Smyth, R. D. G. Neery, O. Tighe, B. Abuaisha, G. Grealy, P. Tyndall, D. S. Gordon, P. M. Bell, M. Dowling, R. D. G. Neely, A. E. Hughes, J. Montwill, P. Keenan, S. Heffeman, M. D. Rollins, C. F. J. Russell, R. J. Atkinson, B. G. McClure, L. Kennedy, P. J. Morrison, Patrick Collins, J. B. Ferriss, S. K. Cunningham, T. F. Fannin, G. Roberts, C. N. Ennis, D. Owens, and D. Cregan

Subjects
medicine.medical_specialty, Irish, business.industry, Family medicine, language, Medicine, Endocrine system, General Medicine, business, language.human_language
Published
1991
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30. Irish Cardiac Society Proceedings of meeting held 23rd–24th November, 1990

Author

A. Stanton, S. Kilfeather, E. O’Brien, K. O’Malley, M. D. I. Donnelly, Y. Batchelor, B. McAleer, G. Dalton, E. Turkington, J. R. Williams, M. P. S. Varma, S. Okeefe, C. Redehan, P. Keane, K. Daly, N. C. Rollins, H. C. Mulholland, B. Craig, H. A. McCann, T. P. Walsh, H. C. Kittrick, E. Keelan, M. Codd, J. McCarthy, C. McCarthy, D. D. Sugrue, A. F. O’Donnell, M. Lonergan, L. Daly, E. M. McGovem, J. G. Murphy, R. S. Schwartz, K. Garratt, D. R. Holmes, B. Foley, R. Sheehan, A. Kinsella, G. Gearty, M. Walsh, P. Crean, J. J. Glazier, J. Piessens, F. Stammen, V. Vergauwen, H. De Geest, J. L. Willems, P. J. Quigley, M. Ohman, J. E. Smith, R. S. Stack, A. F. Rickards, E. McFadden, J. Clarke, G. Davies, A. Maseri, W. Dickey, A. A. J. Adgey, E. W. Chew, P. Morton, J. G. Murtagh, M. E. Scott, D. B. O’Keeffe, B. O’Murchu, M. Miller, J. C. Burnett, M. Rose, M. Gibney, P. O’Connor, S. O’Keeffe, H. Grimes, J. Finn, P. McMurrough, M. J. D. Roberts, J. A. Pruvis, A. J. McNeill, T. J. Trouton, T. G. W. N. Dalzell, G. W. N. Dalzell, D. J. Flannery, C. M. Wilson, G. C. Patterson, S. W. Webb, N. P. S. Campbell, M. M. Khan, A. O. Molajo, B. M. McClements, T. G. Trouton, A. J. O’Neill, J. Adgey, K. Walsh, N. Sreeram, R. Franks, R. Arnold, I. Graham, J. Hurley, M. C. Neligan, A. E. Wood, M. de Buitleir, J. Sousa, H. Calkins, S. Rosenheck, J. Langberg, F. Morady, H. A. Maghur, B. J. Gersh, P. Oslizok, M. Allen, R. N. Gillette, P. Oslizlok, C. Case, P. C. Gillette, D. Duff, and C. Mulholland

Subjects
Irish, business.industry, language, Medicine, Library science, General Medicine, business, language.human_language
Published
1991
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31. Fifteenth Sir Peter Freyer Memorial Lecture and Surgical Symposium Proceedings of meeting held 14th & 15th September, 1990 at University College, Galway

Author

C. Bolger, G. Fry, D. Coakley, J. Philips, N. Sheahan, J. Malone, W. P. Gray, M. O’Sullivan, T. F. Buckley, T. P. O’Dwyer, P. J. Gullane, B. P. Kneafsey, K. T. Moran, S. T. O’Sullivan, M. P. Brady, E. C. Coveney, J. G. Geraghty, N. J. O’Higgins, J. O’Beirne, P. Seighe, J. P. McElwain, J. P. McCabe, B. Waldron, J. Byme, N. Hickey, J. McCabe, J. McMahon, J. Colville, B. J. Moran, R. A. Frost, M. J. Kerin, J. J. Jaeger, C. J. Mitchell, J. MacFie, T. O’Hanrahan, N. A. Scott, D. Leinhardt, M. H. Irving, D. Gough, M. White, M. Morrin, W. Joyce, D. Phelan, J. Fitzpatrick, T. Gorey, D. Wilkinson, A. Parkin, R. C. Kester, E. J. Gibney, K. McGrath, A. J. Cunningham, D. Bouchier-Hayes, M. Barry, M. Farrell, W. Monkhouse, K. J. Dawson, D. Hehir, G. Hamilton, P. A. Grace, A. Quereschi, R. Keane, P. Broe, G. Stansby, B. Fuller, A. Connolly, J. O’Donnell, D. Little, R. M. Keane, M. Regan, P. G. Horgan, C. Curran, D. O’Brien, D. Waldron, E. Mooney, J. Greally, H. F. Given, M. J. Duffy, D. Reilly, E. Coveney, J. Geraghty, J. J. Fennelly, N. O’Higgins, C. M. O’Hare, P. L. Jones, T. A. Zoma, G. P. Hemstreet, R. G. Postier, J. E. Coleman, E. L. Chaikof, E. W. Merrill, A. D. Callow, N. N. Williams, J. M. Daly, M. Herlyn, R. Gaffney, M. Walsh, D. McShane, C. Timon, D. Hamilton, J. Connolly, P. J. Byrne, R. B. Stuart, E. Kay, T. P. J. Hennessy, D. P. O’Leary, M. Booker, T. E. Scott, W. W. LaMorte, J. G. Geraty, W. A. Angerson, D. C. Carter, J. Lyons, A. Stack, J. M. Fitzpatrick, C. Kelly, C. Augustine, J. Kennedy, T. Creagh, D. Mannion, P. Seigne, G. Fitzpatrick, M. Feeley, P. Butler, P. Grace, M. Leader, B. Curren, C. Barry-Walsh, R. Waldron, M. Shearer, S. O’Rourke, M. Galea, A. Gilmour, R. Carter, D. Parkin, R. W. Blarney, D. J. Hehir, S. P. Parbhoo, N. Rothnie, J. Crowe, C. Wells, F. Sherry, P. O’Grady, J. Byrne, S. England, J. O’Callaghan, H. Grimes, Ursula Mulcahy, P. P. A. Smyth, V. McAlister, M. J. Murray, M. J. O’Higgins, R. O. Laoide, J. B. Hourihane, E. F. Mooney, C. Brougham, D. R. Headon, C. Coleman, E. C. Coveny, S. Jazawi, T. N. Walsh, P. Lawlor, H. Li, H. Sanfey, W. P. Joyce, D. B. Gough, P. V. Delaney, T. F. Gorey, S. E. A. Attwood, A. Watson, E. Rogers, R. P. Waldron, G. Glynn, K. U. El-Bouri, J. Flynn, P. Keeling, M. G. Davies, J. Lavelle, M. F. Shine, F. Lennon, R. C. Stewart, T. P. Hennessy, M. V. McKiernan, J. G. Johnston, L. Hanrahan, H. C. Bredin, M. O. Corcoran, M. Norton, R. Flynn, M. Gleeson, R. Grainger, T. E. D. McDermott, D. Lanigan, P. McLean, B. Curran, M. J. Gleeson, D. P. Griffin, H. J. Gallagher, T. A. Creagh, D. M. Mulvin, M. G. Donovan, D. M. Murphy, P. A. McLean, D. W. Mulvin, A. O’Brien, K. L. O’Flynn, R. McDonagh, D. G. Thomas, T. H. Lynch, P. Anderson, A. T. M. Vaughan, R. P. Beaney, D. M. A. Wallace, L. Solomon, D. S. O’Riordain, P. R. O’Connell, W. O. Kirwan, Hui Li, R. C. Stuart, S. Jazrawi, T. N. Koh, S. J. Sheehan, J. McKeever, J. Donohoe, M. Carmody, D. H. Osborne, D. E. Waldron, E. Rodgers, F. Patel, P. Horgan, M. Corcoran, K. Walsh, J. M. O’Donoghue, O. J. McAnena, M. McGuire, J. Smyth, G. Keye, A. Bahadursingh, C. Delaney, A. J. Richie, J. R. P. Gibbons, M. Marples, J. Banacewicz, H. Troidl, L. Cassidy, E. J. Prenderville, P. E. Burke, M. -.P Colgan, B. L. Wee, D. J. Moore, G. D. Shanik, K. S. Cross, M. El-Sanadiki, J. J. Murray, E. Mikat, R. McCann, P. -O. Hagen, T. R. Cheatle, E. Steibe, P. D. Colebridge Smith, J. H. Scurr, K. Barry, E. Bresnihan, D. F. Courtney, D. S. Quill, D. Buckley, D. S. O’Riordan, J. A. O’Donncll, J. A. O’Donnell, A. D. K. Hill, P. J. O’Dwycr, D. P. MacErlean, N. F. Couse, D. Campbell, K. McBride, D. MacErlean, J. J. Murphy, K. Kaar, H. Docrat, S. Malik, J. Egan, I. R. Davidson, J. Hurley, and H. Rowley

Subjects
Artificial urinary sphincter, medicine.medical_specialty, Fifteenth, Chronic venous insufficiency, business.industry, Intestinal failure, General surgery, medicine, General Medicine, medicine.disease, business, Laparoscopic cholecystectomy
Published
1991
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32. Are elevated levels of the tumour marker CA19-9 of any clinical significance? — An evaluation

Author

Ray McLaughlin, H. Grimes, Deirdre M. O’Hanlon, Patrick J. Kenny, H. F. Given, and Michael J. Kerin

Subjects
Male, medicine.medical_specialty, Pathology, CA-19-9 Antigen, endocrine system diseases, Bilirubin, Adenocarcinoma, Sensitivity and Specificity, Gastroenterology, Diagnosis, Differential, chemistry.chemical_compound, Lactate dehydrogenase, Internal medicine, Pancreatic cancer, Biomarkers, Tumor, medicine, Humans, Clinical significance, Aged, Gastrointestinal Neoplasms, Retrospective Studies, business.industry, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, digestive system diseases, Pancreatic Neoplasms, chemistry, Alkaline phosphatase, Female, CA19-9, business
Abstract

CA 19-9 is a tumour marker which has been used widely in patients with pancreatic adenocarcinoma. Elevated levels are associated with advanced disease at presentation and disease progression during follow-up. CA19-9 levels may also be elevated in a variety of other malignant and benign conditions. This study examined the significance and implications of elevated CA19-9 levels. An analysis of all CA19-9 measurements performed over a 4 yr period was undertaken and 204 patients with elevated CA19-9 levels were identified. One hundred and thirty patients (63.7 per cent) had malignant conditions and 74 (36.3 per cent) had benign conditions or no definite cause was found. There was a significant correlation between CA19-9 levels and CEA (r = 0.3137; P0.001) as well as alkaline phosphatase, ALT, AST, bilirubin, gamma glutamyl transpeptidase and lactate dehydrogenase. CA19-9 levels were significantly lower in patients with benign pathology than those with malignant pathology. Similar differences were observed for CEA. CA19-9 levels were in fact highest in patients with pancreatic carcinoma (P0.05) while no significant differences were observed for CEA. In conclusion CA19-9 may be elevated in both benign as well as malignant conditions and interpretation of CA19-9 results must be made in light of the clinical condition of the patient.

Published
1999
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33. Evaluation of carboplatin dosage based on 4-variable modification of diet in renal disease equation

Author

P. Donnellan, A. Barry, H. Grimes, Roisin E. O'Cearbhaill, Damian G Griffin, and M. Keane

Subjects
Adult, Male, medicine.medical_specialty, Statistics as Topic, Urology, Renal function, Nutritional Status, Antineoplastic Agents, urologic and male genital diseases, Carboplatin, chemistry.chemical_compound, Impaired renal function, Internal medicine, medicine, Retrospective analysis, Humans, reproductive and urinary physiology, Calvert formula, Aged, Retrospective Studies, Body surface area, Aged, 80 and over, Creatinine, business.industry, Nutritional status, General Medicine, Middle Aged, female genital diseases and pregnancy complications, Diet, Endocrinology, chemistry, Female, Kidney Diseases, business, Glomerular Filtration Rate
Abstract

Traditionally, carboplatin dosage is based on the Calvert formula. Glomerular filtration rate (GFR) and creatinine clearance (CrCl) are often used interchangeably in this formula. The modification of diet in renal disease (MDRD) equation is now routinely available to estimate GFR (eGFR). We performed a retrospective analysis of carboplatin dosage in our institute. Calvert formula derived carboplatin dose using eGFR calculated from the MDRD equation was compared to estimated CrCl from the Cockcroft-Gault and Jelliffe equations. Ninety-two carboplatin treatment episodes were recorded. eGFR and CrCl correlated reasonably well with a correlation coefficient (r) of 0.88. The correlation was weakest at lower levels of serum creatinine. Correcting eGFR for body surface area resulted in a tighter correlation (r = 0.94). The MDRD derived eGFR is readily available and may prove very useful in calculating carboplatin dosage for patients with impaired renal function.

Published
2008

34. Irish endocrine society

Author

C. H. Walsh, A. L. Murphy, S. Cunningham, T. J. McKenna, B. Byrne, D. Igoe, S. K. Cunningham, M. Culliton, C. Costigan, J. A. McKnight, D. R. McCance, G. Roberts, B. Sheridan, A. B. Atkinson, O. Lanigan, P. O’Leary, T. Moran, P. P. A. Smyth, D. R. Hadden, L. Kennedy, D. Foley-Nolan, A. Foley-Nolan, D. Temperley, J. Devlin, P. M. Bell, R. D. G. Neely, D. P. Rooney, E. R. Trimble, J. D. M. Edgar, R. Doherty, A. B. Atkinsion, J. A. O’Hare, L. Rand, A. Krolewski, C. McKenna, J. McKieman, H. M. Whitehead, K. Buchanan, Davina Fillmore, Joy Ardill, C. Johnston, Wendy Robinson, G. Silvestri, J. A. Dunn, D. G. Dwyer, J. W. Baynes, T. J. Lyons, D. Owens, J. Stinson, P. Collins, A. Johnson, G. Tomkin, D. F. Smith, D. O’Carroll, M. Murray, N. J. O’Higgins, A. M. Hetherton, T. B. Counihan, D. B. R. Poole, D. K. O’Donovan, H. Grimes, and J. O’Donnell

Subjects
Metyrapone, business.industry, Physiology, General Medicine, Renal artery stenosis, medicine.disease, Plasma renin activity, language.human_language, Irish, medicine, language, Endocrine system, business, medicine.drug
Published
1990
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35. Royal academy of medicine in ireland section of biological sciences

Author

J. P. McCabe, R. P. Waldron, M. J. Kerin, D. F. Courtney, H. F. Given, O. J. McAnena, H. Grimes, P. M. Tymkewycz, P. S. Gascoine, P. J. Gaffney, P. Felle, S. Gaine, J. Cox, R. England, J. Walsh, D. Coakley, J. Feely, E. O’Brien, K. O’Malley, L. Daly, B. L. Sheppard, E. Carroll, B. Hennelly, J. Bonnar, M. M. Fahy, V. Carragher, M. T. Kane, S. McGuinness, I. Pratt, M. P. Ryan, P. A. Cahill, S. Daly, A. K. Keenan, R. P. Barrett, M. J. Rowan, Maria Smyth, G. O’Cuinn, S. C. Sharma, S. Feely, M. Kennedy, R. G. O’Regan, Gwen Hughes, J. M. Allen, N. G. McHale, K. D. Thombury, S. Croal, J. McC Anderson, J. D. Allen, J. P. Jamison, C. G. Mercer, A. E. Gracey, N. Flynn, D. P. Otoole, A. P. Clery, A. J. Cunningham, J. W. Dundee, R. G. Ghaly, Jing Yang, A. B. Etwebi, A. A. Alazreg, S. M. Lavelle, A. Etwebi, F. R. Comerford, N. Donohoe, Godeliver A. B. Kagashe, B. E. Leonard, J. P. Kelly, C. Bannon, P. Nolan, A. Bradford, H. McGlynn, B. Kavanagh, Caroline G. Bullock, Brigid A. O’Connor, Corinna J. Pippard, W. F. M. Wallace, P. C. Holland, M. Blake, E. Redmond, E. M. Redmond, M. Brennan, R. Anwyl, A. Gaynor, R. G. Luckwill, M. Caldwell, O. Lyons, D. McNamara, A. Lynott, F. Fleming, R. Walsh, L. Farrell, C. H. Homer, P. Glacken, M. O’Brien, J. Caird, A. Grogan, C. Y. Ng, A. Arora, M. Carroll, E. McKone, D. O’Gradaigh, P. M. R. O’Reilly, M. J. T. FitzGerald, S. Tierney, J. Russell, and J. C. Folan

Subjects
business.industry, Section (typography), Medicine, Library science, General Medicine, business, Biological sciences
Published
1990
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36. Delay fault simulation with bounded gate delay mode

Author

S. Bose, H. Grimes, and Vishwani D. Agrawal

Subjects
Delay calculation, Computer science, Elmore delay, Hardware_PERFORMANCEANDRELIABILITY, Fault (power engineering), Control theory, Bounded function, Logic gate, Path (graph theory), Hardware_INTEGRATEDCIRCUITS, Electronic engineering, AND gate, Hardware_LOGICDESIGN, Electronic circuit
Abstract

Previously reported work on path and gate delay tests fail to analyze path reconvergences when a bounded gate delay model is used. While robust path delay tests are of the highest quality, most path faults are only testable nonrobustly. Many non-robust tests are usually found but, in practice, are easily invalidated by hazards. The invalidation of non-robust tests occurs primarily due to non-zero delays of off-path circuit elements that may reconverge. Thus, non-robust tests are of limited value when process variations cause gate delays to vary. For gate delay faults, failure to recognize the correlations among the ambiguity waveforms at inputs of reconvergent gates cause fault coverages to be optimistic. This paper enhances a recently published ambiguity simulation algorithm [5] to accurately measure both non-robust path and gate delay coverages for the bounded delay model. Experimental results for the ISCAS circuits show accurate results are often 20-30% less than the optimistic ones that fail to analyze signal reconvergences.

Published
2007
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37. An audit of fiducial marker placement within the prostate for radiotherapy treatment verification; and its potential impact on margin generation

Author

Reena Davda, Heather Payne, S. Moinuddin, H. Grimes, P. Abi-Aad, and Anita Mitra

Subjects
Potential impact, medicine.medical_specialty, business.industry, Audit, medicine.anatomical_structure, Oncology, Prostate, Margin (machine learning), medicine, Radiology, Nuclear Medicine and imaging, Radiotherapy treatment, Radiology, Fiducial marker, business
Published
2015
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38. Bim expression in early DP thymocytes limits development of TCRαβ+DN thymocytes and CD8αα intestinal intraepithelial lymphocytes (HEM2P.243)

Author

Kun-Po Li, Eron Roy, Carla Cuda, H Grimes, Harris Perlman, and David Hildeman

Subjects
Immunology, Immunology and Allergy
Abstract

Thymocyte negative selection is thought to cull T cells with strong self-reactivity and maintain T cells with non-self-specificity. While initial work implicated Bim as a critical mediator of thymocyte negative selection, its role in the process has been controversial. Thus, we re-examined thymocyte development in mice with global and T cell specific loss of Bim. We found that global Bim-/- mice had a striking accumulation of DN4 thymocytes expressing high levels of surface TCR, which failed to generate DP cells in OP9-DL1 culture. Interestingly, CD4Cre-driven deletion of Bim promoted DN4 cells, but later, dLckCre-driven deletion of Bim did not. Combined, these data show that the aberrant DN4 cells in Bim-/- mice were once DP cells, but had lost co-receptor expression. Investigating the fate of these cells, we found that splenic DN T and gut CD8αα T cells were increased in Bim-/- mice. While IL-15 is critical for both DN/CD8αα T cells, the additional loss of Bim partially restored DN/CD8αα T cells in IL-15 deficient mice, suggesting that IL-15 signals antagonize Bim to promote DN T and CD8αα T cells. Finally, TCR or IL-15 signals were sufficient to promote expression of both CD8αα and the gut homing receptor CCR9 on splenic DN T cells. In conclusion, these data further delineate the role of Bim on thymocyte fate and DN/CD8αα T cell development; and show that dLckCre-Bimf/f mice can isolate the effects of Bim on peripheral T cell survival without affecting thymic selection.

Published
2015
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39. Mechanical transmission of Cryptosporidium parvum oocysts by flies

Author

Thaddeus K, Graczyk, Barbara H, Grimes, Ronald, Knight, Beata, Szostakowska, Wiesława, Kruminis-Lozowska, Maria, Racewicz, Leena, Tamang, Alexandre J, Dasilva, and Przemysław, Myjak

Subjects
Cryptosporidium parvum, Male, Feces, Diptera, Oocysts, Animals, Cattle Diseases, Cryptosporidiosis, Humans, Cattle, Host-Parasite Interactions, Insect Vectors
Abstract

Long term field studies and laboratory experiments demonstrated that synanthropic filth flies can mechanically transmit infectious oocysts of Cryptosporidium parvum, an anthropozoonotic protozoan parasite which significantly contributes to the mortality of immunocompromised or immunosuppressed people. C. parvum oocysts are acquired from unhygienic sources, and can pass trough fly gastrointestinal track without alteration of their infectivity and can be subsequently deposited on visited surfaces. Transmission of the oocysts by adult flies occurs via: (1) mechanical dislodgement from the exoskeleton; (2) fecal deposition; and (3) regurgitation, i.e., vomits. Filth flies can cause human or animal cryptosporidiosis via deposition of infectious oocysts on the visited foodstuf, and the biology and ecology of synanthropic filth flies indicate that their potential for mechanical transmission of C. parvum is high.

Published
2006

40. Vitamin d insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

Author

Eamon C Mulkerrin, C. McGreevy, N ni Chadhain, E DeLappe, H Grimes, and Timothy O'Brien

Subjects
medicine.medical_specialty, Hypercalcaemia, high prevalence, d deficiency, parathyroid-hormone, fracture risk, Population, Medicine (miscellaneous), postmenopausal women, Cohort Studies, secondary hyperparathyroidism, hypovitaminosis d, Internal medicine, medicine, Vitamin D and neurology, Humans, Prospective Studies, elderly-people, education, Prospective cohort study, Aged, Aged, 80 and over, education.field_of_study, Osteomalacia, Nutrition and Dietetics, Bone Density Conservation Agents, business.industry, vitamin d, medicine.disease, Vitamin D Deficiency, Surgery, Calcium, Dietary, Hospitalization, insufficiency, Treatment Outcome, Parathyroid Hormone, controlled-trial, Cohort, Dietary Supplements, supplementation, Secondary hyperparathyroidism, Calcium, Female, bone-mineral density, business, Cohort study
Abstract

Objectives: A significant proportion of the older population may exhibit vitamin D insufficiency. We sought to establish the proportion of 25-hydroxyvitamin D (25OHD) insufficient individuals in an older female cohort presenting for acute medical admission and how they responded to supplementation. Design: A prospective cohort study. Setting: Hospital admissions followed up as a population-based study. Subjects: A total of 114 consecutive female acute medical admissions aged over 65 years from November 2003 to January 2004 were enrolled. All admissions with hypercalcaemia, metabolic bone disease (other than osteoporosis/osteomalacia) and creatinine >= 150 mu mol/l were excluded. Interventions: iPTH, calcium and 25OHD levels were measured in each patient. Of the total, 22 were already receiving calcium and vitamin D supplementation at enrolment. The remaining 92 were commenced on 800 IU of vitamin D and 1 g calcium, and levels were reassessed after supplementation for 3 months. Results: 25-Hydroxyvitamin D insufficiency, as defined by a 25OHD concentration of < 50 nmol/l, was present in 86 (75.4%) patients at initial assessment (mean 35.8 nmol/l, s.d. 23.3). Secondary hyperparathyroidism was present in only 36.7% of those with 25OHD deficiency at baseline. Of the total, 51 (44.7%) patients presented for follow-up. 25-Hydroxyvitamin D concentration increased in this group from 42.1 nmol/l (s.d. 26.6) to 59.5 nmol/l (s.d. 27.4) after supplementation, P < 0.001, but 18(35.3%) still remained deficient. There was no significant change in iPTH or calcium following supplementation. Assessment of compliance revealed 6 (11.7%) admitted to partial or non-compliance. Conclusions: Insufficiency of 25OHD was very common in this cohort. Despite calcium and vitamin D supplementation, 25OHD concentrations failed to reach normality in a significant proportion. Maintaining vitamin D and calcium intake at the level of current recommended doses may not be sufficient to ensure adequate 25OHD stores.

Published
2006

41. Detection of Cryptosporidium parvum and Giardia lamblia carried by synanthropic flies by combined fluorescent in situ hybridization and a monoclonal antibody

Author

Thaddeus K, Graczyk, Barbara H, Grimes, Ronald, Knight, Alexandre J, Da Silva, Norman J, Pieniazek, and Duncan A, Veal

Subjects
Cryptosporidium parvum, Giardiasis, Diptera, Cryptosporidiosis, DNA, Protozoan, Insect Vectors, Dairying, Waste Management, North Carolina, Animals, Humans, Cattle, Giardia lamblia, In Situ Hybridization, Fluorescence
Abstract

Wild-caught synanthropic flies were tested for the presence of Cryptosporidium parvum and Giardia lamblia on their exoskeletons and in their digestive tracks by fluorescent in situ hybridization and fluorescein isothiocyanate (FITC)-conjugated monoclonal antibody (MAb) against Cryptosporidium and Giardia cell wall epitopes. The levels of C. parvum were positively correlated with the levels of G. lamblia, indicating a common source of contamination. The majority of oocysts and cysts were potentially viable (C. parvum = 80% and G. lamblia = 69%). More G. lamblia cysts occurred on the exoskeleton of the flies than within the digestive tracts; the opposite relationship was observed for C. parvum. No genotype other than C. parvum G2 was found to be associated with flies. Because filth flies carry viable C. parvum oocysts and G. lamblia cysts acquired naturally from unhygienic sources, they can be involved in the epidemiology of cryptosporidiosis and giardiasis. Fluorescent oligonucleotide probes used together with FITC-conjugated MAb represent a convenient and cost-effective technique for rapid and specific identification of human-infectious species of Cryptosporidium and Giardia mechanically transported by flies, and for the assessment of the viability of these pathogens.

Published
2003

42. Posture-related tachycardia in older patients with hyponatremia

Author

S. K. Biswas, H Grimes, D.A Power, D Jones, S Cannon, Eamon C Mulkerrin, and Hugh R. Brady

Subjects
Aging, Vasopressin, medicine.medical_specialty, Health (social science), Aldosterone, business.industry, Hemodynamics, medicine.disease, Plasma renin activity, chemistry.chemical_compound, Orthostatic vital signs, Endocrinology, chemistry, Atrial natriuretic peptide, Internal medicine, Renin–angiotensin system, medicine, Geriatrics and Gerontology, Hyponatremia, business, Gerontology
Abstract

Hyponatremia (HN) is the commonest electrolyte abnormality in elderly patients. Its etiology in this setting is poorly understood. In this study, the authors aim to compare the hemodynamic and hormonal responses of a group of older patients with a predisposition to HN with a group of age-matched controls. We assessed hemodynamic and hormonal responses to postural challenge in 15 patients over age 65 with serum sodium concentrations of less than 130 mM (mean 128.7 mM) and 15 age-matched controls with normal sodium concentrations. Patients remained recumbent for 1 h and stood for the second. Blood was drawn at baseline and at 15 min intervals. Blood pressure (BP) and pulse rates (PR) were monitored electronically. Plasma arginine vasopressin (AVP), atrial natriuretic peptide (ANP), renin and aldosterone were determined periodically during the study period. No difference in BP between groups was noted. PR increased significantly in the HN group only within 3 min of standing (from 71 +/- 4 to 86 +/- 5, P

Published
2001

43. The prognostic value of the tumor marker CA 15-3 at initial diagnosis of patients with breast cancer

Author

H. Grimes, J McGrath, H. F. Given, and Ray McLaughlin

Subjects
0301 basic medicine, CA15-3, Oncology, Cancer Research, medicine.medical_specialty, Clinical Biochemistry, CA 15-3, Breast Neoplasms, Disease, Sensitivity and Specificity, Disease-Free Survival, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Predictive Value of Tests, Internal medicine, medicine, Humans, Survival analysis, Tumor marker, Neoplasm Staging, business.industry, Mucin-1, Late stage, medicine.disease, Prognosis, Survival Analysis, 030104 developmental biology, 030220 oncology & carcinogenesis, Predictive value of tests, Female, business, Follow-Up Studies
Abstract

CA 15–3 has been most widely used as a serum tumor marker in follow-up and detection of breast cancer recurrence. In this study we have specifically focused upon the prognostic implications and utility of preoperative CA 15–3 levels. We have identified on our database 414 patients with breast cancer in whom serial levels of the serum tumor marker CA 15–3 had been determined at diagnosis and follow-up. We have analyzed the follow-up and clinical outcomes in these patients and from this data we have assessed the potential of CA 15–3 as a predictor of five-year overall and disease-free survival. Our results show that an initially elevated CA 15–3 level is associated with a very poor prognosis in both early and late stage disease. Elevated pre-biopsy CA 15–3 levels are associated with 14% five-year disease-free survival rates and 17% overall survival rates at five years. In contrast, normal CA 15–3 levels are associated with 47% five-year disease-free survival rates and 54% overall survival rates at five years (p

Published
2001

44. Mucin-like carcinoma associated antigen (MCA) at presentation with breast cancer

Author

H. Grimes, Mooney E, J. O’Donoghue, P. G. Horgan, H. F. Given, and J. Byrne

Subjects
Oncology, CA15-3, medicine.medical_specialty, Pathology, Radioimmunoassay, CA 15-3, Breast Neoplasms, Sensitivity and Specificity, Diagnosis, Differential, Breast cancer, Antigen, Antigens, Neoplasm, Reference Values, Internal medicine, medicine, Carcinoma, Biomarkers, Tumor, Humans, Antigens, Tumor-Associated, Carbohydrate, Fibrocystic Breast Disease, Neoplasm Staging, business.industry, Cancer, General Medicine, medicine.disease, Female, Breast disease, business, Precancerous Conditions
Abstract

The usefulness of serum measurements of mucin-like carcinoma associated antigen (MCA) in 100 women at presentation with breast cancer was evaluated. Peripheral venous blood was drawn and MCA values determined by radioimmunoassay. Twenty women presenting with benign breast disease and 20 normal women served as controls. There was no difference in the MCA values between the benign breast disease group and the normal group: 4.1 +/- 0.9 units/ml versus 5.0 +/- 0.75 units/ml (mean +/- sem). The following were the MCA values for patients by stage; stage 1: 11.2 +/- 1.02, stage 2: 11.0 +/- 1.29, stage 3: 20.2 +/- 6.7, stage 4: 31 +/- 5.0. Statistical analysis of stage versus controls showed significant elevations only in stage 3 and 4 disease (p0.05). We conclude that MCA may be a useful serum tumour marker only in advanced breast cancer but is unreliable in detection of early breast cancer.

Published
1997

45. Clinical value of cyfra 21.1, carcinoembryonic antigen, neurone-specific enolase, tissue polypeptide specific antigen and tissue polypeptide antigen in the diagnosis of lung cancer

Author

J J Gilmartin, J Finn, R Rutherford, H Grimes, J Bates, I O'Muircheartaigh, and M Divilly

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Lung Neoplasms, bronchoscopy, Tissue Polypeptide Antigen, Population, Sensitivity and Specificity, Diagnosis, Differential, Cytokeratin, Carcinoembryonic antigen, Antigen, Antigens, Neoplasm, Predictive Value of Tests, Biomarkers, Tumor, medicine, Humans, CYFRA 21-1, education, Tumor marker, lung diseases, Keratin-19, education.field_of_study, biology, business.industry, carcinoembryonic antigen, squamous-cell carcinoma, biological tumour markers, Tissue Polypeptide Specific Antigen, lung cancer, tumor-marker, Phosphopyruvate Hydratase, cyfra 21.1, biology.protein, Keratins, Peptides, business
Abstract

In this study we looked at what useful information cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 (CYFRA 21.1), carcinoembryonic antigen (CEA), neurone-specific enolase (NSE), tissue polypeptide specific antigen (TPS), and tissue polypeptide antigen (TPA) gave when measured prospectively. All patients who were suspected of having lung cancer and who underwent diagnostic bronchoscopy in this hospital between July 1994 and May 1995 were included in the study. Of 184 patients, 87 were subsequently found to have intrathoracic malignancy, 93 were found to have benign lung disease and four were lost to follow-up. CYFRA 21.1 was the most efficient marker in differentiating benign from malignant disease, with a sensitivity of 54% and a positive predictive value of 96%. Thirty seven patients who had a negative bronchoscopy subsequently turned out to have malignant disease. Either CYFRA 21.1 or CEA was elevated in 26 (70%) of such patients. Multivariate analysis showed that only CYFRA 21.1 and CEA contributed significantly to the discriminatory power of the data. We conclude that measurement of cytokeratin fragment detected by antibodies BM 19-21 and KS 19-1 and carcinoembryonic antigen at the time of bronchoscopy significantly increased the diagnostic yield in this population and was especially useful in those patients in whom tumour biopsy was not possible at bronchoscopy.

Published
1997

46. Clinical evaluation of near-continuous oral micronized progesterone therapy in estrogenized postmenopausal women

Author

E. M. O’Dwyer, D F Tallon, G. Mortimer, H. Grimes, Patrick F. Fottrell, and I. I. Bolaji

Subjects
Adult, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Administration, Oral, Asymptomatic, Gastroenterology, chemistry.chemical_compound, Endometrium, Endocrinology, Internal medicine, medicine, Humans, Vaginal bleeding, Prospective Studies, Progesterone, Aged, Climacteric, Gynecology, Estrogens, Conjugated (USP), Cholesterol, business.industry, Estrogen Replacement Therapy, Obstetrics and Gynecology, Hormone replacement therapy (menopause), Middle Aged, Postmenopause, Regimen, chemistry, Estrogen, Amenorrhea, Drug Therapy, Combination, Female, Uterine Hemorrhage, medicine.symptom, business, Lipoprotein
Abstract

In an open non-comparative prospective trial of 12 months' duration, we investigated the role of a novel hormone replacement therapy regimen in 40 post-menopausal women who sought hormone replacement therapy. The regimen consisted of continuous administration of 0.625 mg of conjugated equine estrogen coupled with a fixed low-dose of micronized oral progesterone administered for 23 days every calendar month. The regimen was well-tolerated, producing no major side-effects and was effective in relieving menopausal symptoms. The study showed that 40% of the women experienced side-effects and 20% withdrew from the study. Half of the 20% of the women who dropped out did so for reasons not related to treatment. All symptomatic women experienced improvement after the 1st month, and virtually all were asymptomatic by the 3rd month of treatment, persisting until the end of the trial with the average number of hot flushes per day declining from the pretreatment levels by 96%. Amenorrhea was observed in 47% of patients, amenorrhea and minimal vaginal bleeding in 78% but acyclic bleeding was present in 28% of those in whom bleeding was re-established. Endometrial atrophy was induced in the majority of patients and no atypical endometrial hyperplasia was encountered. No significant changes were observed in blood glucose or liver enzymes. The mean percentage changes from baseline for serum cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoproteins (LDL) and LDL/HDL ratio were -6%, +32% (p < 0.001), -16% (p < 0.05), +15% (p < 0.05) and -23% (p < 0.05), respectively. The regimen was clinically effective and its apparent lack of major side-effects, the protective effect on the endometrium, the added advantage of minimal vaginal bleeding and the beneficial effect on lipid/lipoprotein levels, offer an attractive therapy and improved compliance with postmenopausal hormone replacement therapy.

Published
1996

47. An evaluation of preoperative ca 15-3 measurement in primary breast carcinoma

Author

H. Grimes, Michael J. Kerin, D. Maher, H. F. Given, Deirdre M. O’Hanlon, and P. Kent

Subjects
tumors, Cancer Research, medicine.medical_specialty, Pathology, ca15-3, Mammary gland, monoclonal-antibodies, CA 15-3, Breast Neoplasms, Enzyme-Linked Immunosorbent Assay, Sensitivity and Specificity, Gastroenterology, Predictive Value of Tests, Internal medicine, medicine, Carcinoma, Humans, ca 15-3, Neoplasm Invasiveness, Neoplasm Metastasis, Stage (cooking), Lymph node, Neoplasm Staging, breast neoplasia, Epithelioma, business.industry, Mucin-1, Middle Aged, medicine.disease, df3, Postmenopause, antigen levels, medicine.anatomical_structure, Premenopause, Receptors, Estrogen, Oncology, Lymphatic Metastasis, Predictive value of tests, tumor marker, Female, Breast carcinoma, business, cancer patients, Research Article
Abstract

In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml(-1) has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.

Published
1995

48. A prospective evaluation of CA15-3 in stage I carcinoma of the breast

Author

D M, O'Hanlon, M J, Kerin, P J, Kent, R, Skehill, D, Maher, H, Grimes, and H F, Given

Subjects
Adult, Aged, 80 and over, Mucin-1, Bone Neoplasms, Breast Neoplasms, Middle Aged, Prognosis, Predictive Value of Tests, Biomarkers, Tumor, Humans, Female, Prospective Studies, Neoplasm Recurrence, Local, Aged, Neoplasm Staging
Abstract

Carcinoma of the breast is characterized by a variable course with prognosis dependent on disease stage at presentation. Paradoxically, some patients with early malignancy demonstrate disease progression within a short time. The role of tumor markers in the management of carcinoma of the breast is controversial. While CA15-3 is the most widely used tumor marker in carcinoma of the breast, its role in the management of patients with early disease is controversial.Since 1986, all patients presenting to our unit with carcinoma of the breast have had serial CA15-3 levels measured. This study evaluates the role of serial CA15-3 levels in the management of a consecutive series of 168 patients with Stage I disease at presentation.The mean preoperative CA15-3 levels at presentation were significantly elevated in patients with Stage I disease compared with patients with benign disease. Sixteen patients had either locoregional (five patients) or metastatic recurrence (11 patients). CA15-3 levels were not elevated in patients with locoregional disease and were significantly elevated in patients with bony metastases and gave a mean lead time of 6.3 months over bone scintigraphy.Serial CA15-3 measurements are an efficient and cost-effective method of monitoring disease progression and have advantages over conventional investigations in patients with early carcinoma of the breast.

Published
1995

49. EP-1504 DOSE CONTRIBUTION FROM COMPONENT ARCS IN DUAL ARC OPTIMISATION FOR LUNG SBRT; IMPLICATIONS FOR PATIENT DOSE DELIVERY

Author

C. Stacey, U. Johnson, and H. Grimes

Subjects
Arc (geometry), Oncology, Homogeneous, business.industry, Homogeneity (statistics), Robust optimization, Radiology, Nuclear Medicine and imaging, Patient dose, Hematology, Nuclear medicine, business, Mathematics, Homogeneity index
Abstract

errors up to 1 cm in the anterior direction. The resulting DVHs of the two methods were highly similar. When using IMRT for the three cases, robust optimization resulted in less homogeneity in the nominal scenario and more homogeneity in the shifted scenario than the virtual bolus method. For VMAT, robust optimization resulted in more homogeneous plans for all cases and scenarios. Mean dose statistics over the three patient cases are presented in Table 1. Table 1. Mean dose statistics over the three patient cases for the robust optimization method and the virtual bolus method in the nominal scenario and with the patient shifted 1 cm anteriorly (in parentheses). The homogeneity index (HI) is defined as (D2-D98)/D50 and denotes the mean dose.

Published
2012
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50. Seventeenth sir peter freyer memorial lecture and surgical symposium

Author

D. O’Gradaigh, P. J. Byrne, P. Gillen, P. Lawlor, T. N. Walsh, T. P. J. Hennessy, S. T. O’Sullivan, G. C. O’Sullivan, W. O. Kirwan, H. Li, M. T. P. Caldwell, S. Hone, S. E. A. Attwood, I. P. Kelly, T. P. Corrigan, E. Mulligan, M. J. Kerin, N. N. Williams, K. J. Cronin, M. El Sadar, P. Dervan, J. M. Fitzpatrick, T. F. Gorey, M. Maher, D. Hehir, A. Horgan, R. Stuart, J. A. O’Donnell, M. P. Brady, J. M. O’Donoghue, J. R. Flynn, J. Doyle, M. Gallagher, K. Connolly, M. Barry, M. G Davies, M. West, E. O’Broin, J. A. Connolly, D. Long, M. F. Shine, F. Lennon, K. J. Dawson, J. R. Novell, A. K. Burroughs, K. Rolles, W. P. Joyce, J. Dolan, J. Hyland, O. Traynor, M. Bennett, O. Tighe, H. Mulcahy, D. O’Donoghue, D. Bouchier-Hayes, D. T. Croke, G. Santos, G. Khoury, M. C. Winslet, A. A. M. Lewis, E. Beausang, K. Mealy, L. Joyce, M. McNicholls, D. McErlean, M. A. Stokes, K. Barry, R. Sullivan, J. Byrne, J. Callaghan, T. O’Gorman°, H. F. Given, M. S. Dudeney, M. P. Redmond, J. M. Deasy, V. K. Young, R. G. K. Watson, G. O’Kane, K. Murphy, C. McDowell, K. Khan, S. K. Al-Ghazal, J. McCann, R. C. Stuart, M. O’Connor, J. McCabe, J. O’Byrne, D. O’Farrell, M. Walsh, J. O’Beirne, S. O’Flannagan, A. McGuinness, O. Brady, W. Quinlan, J. P. McCabe, B. Curtin, M. Stephens, J. Stack, P. McCarthy, M. Schnall, H. Pollack, T. H. Lynch, B. Waymont, J. A. Dunn, M. A. Hughes, D. M. A. Wallace, T. E. D. McDermott, R. Grainger, E. Rogers, M. Corcoran, H. Bredin, H. Grimes, D. Lanigan, C. Roobottom, P. A. Dubbins, R. G. Choa, T. Creagh, M. R. Butler, K. J. O’Flynn, R. P. MacDonagh, D. G. Thomas, K. Dawson, J. Aitken, B. Cooke, S. P. Parbhoo, P. M. Cannon, S. C. Low, A. Dixon, I. O. Ellis, C. W. Elston, R. W. Blarney, E. D. Mulligan, K. Cronin, A. Stack, J. Ennis, F. Abbaskoor, M. K. O’Donoghue, G. Fulton, W. A. Tanner, F. B. V. Keane, B. V. Joseph, F. O. Cunningham, M. Dowling, E. Conveney, J. G. Geraghty, P. Byrne, G. Clarke, J. Duffy, N. O’Higgins, D. O’Hanlon, P. G. Horgan, D. O’Brien, C. Phelan, P. Given, P. Kent, S. Sheehan, M. P. Colgan, D. Moore, G. Shanik, P. Murphy, R. Vashisht, M. Sian, P. Franks, M. K. O’Malley, Y. Gul, D. Waldron, W. P. Hederman, H. P. Singh, S. Dias, T. Aherne, D. J. Hehir, J. A. McKeever, C. A. Bannon, D. Mehigan, T. V. Keaveney, T. F. Browne, U. M. Sivananthan, M. R. Rees, S. Whittaker, G. A. Davies, R. Vashisght, E. Sharp, A. Coady, A. Sterpetti, R. M. Greenhalgh, D. P. O’Brien, D. B. Gough, M. C. Regan, I. E. Efron, S. I. Kirk, M. Hurson, H. L. Wasserkrug, A. Barbul, S. Haynes, J. Thornton, J. Sparkes, A. D. K. Hill, C. J. Kelly, J. Gallagher, L. Modyka, H. P. Redmond, J. M. Daly, O. M. Austin, R. J. Cunney, P. A. Grace, C. Curran, J. O’Donoghue, M. Abernathy, N. Sharpe, M. Lucy, E. W. D. McDermott, P. M. Mercer, N. J. O’Higgins, G. Murugasu, A. Groeschel, M. Carmody, J. Donohue, D. H. Osborne, M. McLaughlin, J. Devlin, J. P. Phillips, Y. Ellias, M. Tahir, J. McKeever, M. Tighe, V. Lynch, M. Ahmed, P. P. A. Smyth, A. M. Hetherton, P. Horgan, M. Little, D. S. Quill, C. O. Duncan, M. O’Donnell, J. A. E. Hobby, D. Little, M. Murphy, P. Burke, P. Broe, M. McKiernan, S. J. Kirk, J. Crowe, P. MacMathuna, J. Lennon, T. Corrigan, R. O’Connell, A. Browne, A. Quershi, A. Leahy, G. Courtney, P. Grace, H. Osborne, D. J. Buckley, M. Goggin, T. A. Farrell, J. Geraghty, F. K. Keeling, P. R. O’Connell, H. Naama, E. Moore, E. Barry, C. Duffy, P. Hogan, G. Nee, M. Fahy, D. P. Kenny, V. Ellias, E. Gibney, W. Joyce, E. Gaffney, J. McMahon, M. McCabe, P. Kelly, M. Leader, C. I. Timon, P. Gullane, I. Dardick, I. McCarthy, N. F. Couse, M. Morrin, and P. V. Delaney

Subjects
General Medicine
Published
1994
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