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Abstract: Uranium, the primary fuel source for nuclear power reactors, is one of the most crucial components in new energy production. Currently, uranium is mainly mined from land ore, which will be exhausted within 200 years. As the world's largest uranium reservoir, the ocean is an ideal source for people to obtain these industrial resources. However, the low concentration of uranium (typically about 3.3 ug/L) in seawater poses a great challenge for the project uranium extraction from seawater. The porous aromatic framework (PAF) is a new type of porous nano-solid material with chemical stability, robust framework, and inherent porosity, making itself being the promising material for uranium capturing from aqueous solutions. The progress and advancements of PAFs and PAF-based materials as adsorbents for uranium extraction from aqueous solutions are detailed in this review. Then, several common utilized ways to enhance PAF-based materials’ adsorption performance are discussed. Finally, the authors make a summary and perspective on the opportunities and challenges of this kind of nanomaterials to provide some relevant information on designing PAFs and PAF-based materials for Uranium Extraction from seawater.

Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis is a type of iron-mediated cell death that can suppress liver transformation. Previous studies have linked HBV to ferroptosis in liver fibrosis and acute liver failure. However, whether ferroptosis is involved in HBV-mediated liver cancer is poorly understood. Here, we identified heat shock protein family A member 8 (HSPA8) as a crucial host factor that modulates HBV replication and ferroptosis in liver cancer. Hepatitis B X protein (HBx) upregulated HSPA8 by coactivating the transcription factor heat shock factor 1 (HSF1) in cells. HSPA8 enhanced HBV replication by recruiting hepatitis B core protein (HBc) to the HBV covalently closed circular DNA (cccDNA) minichromosome, forming a positive feedback loop. Moreover, HSPA8 suppressed ferroptosis in liver cancer cells by upregulating the expression of SLC7A11/GPX4 and decreasing erastin-mediated reactive oxygen species and Fe2+ accumulation in cells in vitro and in vivo. Inhibition of HSPA8 reduced the growth of HBV-positive liver tumors and increased sensitivity to erastin. In conclusion, HBx-elevated HSPA8 regulates both HBV replication and ferroptosis in liver cancer. Targeting HSPA8 could be a promising strategy for controlling HBV and hepatocarcinogenesis. Significance: HBV-induced upregulation of HSPA8 promotes hepatocarcinogenesis by suppressing ferroptosis and stimulating HBV replication, identifying HSPA8 as a potential therapeutic target in liver cancer.

Xinhua Zou, Qingyu Xu, Ran You, Guowen Yin Department of Tumor Interventional Therapy, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing City, People’s Republic of ChinaCorrespondence: Guowen Yin, Tel +86-19868589105, Email jsnjgwy@163.comPurpose: To evaluate the efficacy and safety of TACE combined with regorafenib plus PD-1 inhibitor as a second-line therapy for hepatocellular carcinoma after sorafenib resistance.Materials and Methods: The clinical data of 76 patients with hepatocellular carcinoma who were drug-resistant to sorafenib from September 2018 to May 2022 in the tumor intervention department were collected. Among them, 35 patients used TACE combined with regorafenib plus PD-1 inhibitor (TACE-R-P) as second-line treatment, and the remaining 41 patients used TACE combined with regorafenib (TACE-R) as second-line treatment. The mRECIST (modified Response Evaluation Criteria in Solid Tumors) standard was used to evaluate the therapeutic effect. The progression-free survival (PFS) and overall survival (OS) of the two groups were compared. Blood samples were collected before and after treatment to detect the changes in biochemical indicators, and the adverse events (AEs) related to treatment were recorded.Results: A total of 76 patients were included in the study, including 35 patients receiving TACE-R-P treatment and 41 patients receiving TACE-R treatment. Patients in the TACE-R-P group had longer median OS (19.7months vs 15.2months, HR:0.7716, 95% CI:0.4767– 1.2490, P=0.03), longer median PFS (6.3months vs 3.8months, HR:0.6032, 95% CI:0.3727– 0.9763, P=0.0029), higher objective response rate (37.14% vs 19.51%, P=0.001) and higher disease control rate (71.43% vs 48.78%, P=0.001) than those in the TACE-R group. Multivariate analysis showed that Child–Pugh grade (B/A; HR=1.283, 95% CI: 0.623– 1.707, P=0.014), PVTT (Yes/No, HR=1.455, 95% CI: 0.977– 2.038, P=0.018), extrahepatic metastasis (Yes/No, HR=1.766, 95% CI: 1.135– 2.302, P=0.022) and treatment option (TACE-R/TACE-R-P, HR=1.930, 95% CI: 1.461– 2.850, P=0.017) were independent prognostic factors for OS. There was no significant difference in the incidence and severity of AEs between the two groups.Conclusion: TACE-R-P treatment can be more effective than TACE-R treatment for HCC after sorafenib resistance and can be given priority as a second-line treatment for HCC.Keywords: hepatocellular carcinoma, transarterial chemoembolization, regorafenib, sorafenib, PD-1 inhibitor

To reduce the cost of human and material resources and improve the collaborations among medical systems, research laboratories and insurance companies for healthcare researches and commercial activities, electronic medical records (EMRs) have been proposed to shift from paperwork to friendly shareable electronic records. To take advantage of EMRs efficiently and reduce the cost of local storage, EMRs are usually outsourced to the remote cloud for sharing medical data with authorized users. However, cloud service providers are untrustworthy. In this paper, we propose an efficient, secure, and flexible EMR sharing system by introducing a novel cryptosystem called dual-policy revocable attribute-based encryption and tamper resistance blockchain technology. Our proposed system enables EMRs to be shared at a fine-grained level and allows data users to detect any unauthorized manipulation. Moreover, the key generation center can revoke malicious users without affecting the honest users. We provide the formal security model as well as the concrete scheme with security analysis. The experimental simulation and experimental analysis of our proposed scheme demonstrate that our proposed system has superior performances to the most relevant solutions.

A biocompatible, injectable, and thermalsensitive hydrogel, HTA, exhibited tumor-killing and reprogramming of TAMs effects by photothermal therapy.

Herein, we report a green and sustainable Cu-catalysed Chan–Lam oxidative protocol for the synthesis of (hetero)aryl selenides/sulfides from diorganyl dichalcogenides and (hetero)aryl boronic acids in an aqueous micellar medium.

The coupled heat and moisture actions could easily cause deformation, cracking and corrosion problems in the slab ballastless track under operational conditions via China Railway Track System (CRTS) Ⅱ. In this paper, two one-quarter-scaled models of CRTS Ⅱ slab ballastless track under hygro-thermal environment were tested in a testing chamber, respectively. To study the effect of constrained conditions on the structural performance of track structure, temperature distribution, stress and displacement of two scaled models with constrained and free boundary conditions were also compared. Then, the temperature and stress field of the track structure was investigated by establishing a finite-element model. The results showed that the temperature transfer between layers has a temperature-lag effect. The positive and negative temperature gradients between the lower part of the track slab and the cement asphalt (CA) mortar layer of the constrained specimen are smaller than those of the free specimen. The longitudinal displacement of the track slab for the free specimen is significantly affected under the hygro-thermal environment and the longitudinal displacement of the concrete base and the track slab forms a displacement difference. Numerical-analysis results showed that the bottom of the concrete base is prone to produce a high-temperature core and that the temperature inside the track structure forms an agglomeration effect. KEYWORDS: Slab track, Hygro-thermal environment, Structural performance, Scale model, Finiteelement model.

The effect of steel and polypropylene fibers on chloride transport in saturated and unsaturated mortars was investigated. Meanwhile, the pore structure of fiber reinforced mortar and the micromorphology of the fiber–mortar interface were analyzed.

Benefiting from the powerful computing and storage capabilities of cloud services, data sharing in the cloud has been permeated across various applications including social networks, e-health and crowdsourcing transportation system. Intuitively, outsourcing data to untrusted cloud commonly raises concerns about data privacy breaches. To combat this, one approach is exploiting Broadcast Based Searchable Encryption (BBSE) for secure data sharing. Nevertheless, the latest proposed BBSE is still defective in either security or efficiency. In this paper, we propose ESPD, an Efficient, Scalable and Privacy-preserving Data sharing framework over encrypted cloud dataset. Different from previous works, ESPD supports sharing target data to multiple users with distinct secret keys, and keeps a constant ciphertext length with the changes of the amount of system users. This feature significantly improves search efficiency and makes ESPD scalable in real-world scenarios. We show a formal analysis to prove the security of ESPD in terms of file privacy, keyword privacy and trapdoor privacy. Also, extensive experiments on real-world dataset are conducted to indicate the desirable performance of ESPD compared to other similar schemes.

The population of cloud computing greatly facilitates the sharing of explosively generated image today. While benefiting from the convenient of cloud, the privacy protection mechanism that commonly applied in cloud service makes the spreading of illegal and harmful data very hard to be detected or controlled. Such a realistic threat should be seriously treated, yet is largely overlooked in the literature. To address this issue, we propose the first cloud service framework that can simultaneously provide privacy protection and content regulation for the cloud storage image. In specific, we design a secure multi-party computation (MPC) protocol to protect the data privacy via random projection. By leveraging the distance preserving properties residing in random projection, we propose a privacy-preserving principal component analysis (PCA)-based recognition approach over the random projection domain to achieve content matching while respecting the data privacy. To facilitate the efficiency, we implement our system under the compressive sensing (CS) framework. Due to the compression effect of CS, the proposed cloud service can achieve remarkable reduction on the computation and communication complexity of the content matching process. Theoretical analysis and experimental results both show that our system can achieve privacy assurance and acceptable recognition performance, while with high efficiency.

In the modern communication markets, thousands of communication methods are available for different situations, among these different means of communication, the ZigBee protocol, IEEE 802.15, and the derivative protocols provided possible solutions of cheap and energy-saving wireless communication methods, which were considered major members of modern communication. However, these technologies carried the drawbacks like low data rate and difficulties to build a complicated system. On one other hand, wired communications like Bus communications have features like high data rate and high data quality, on the other hand, the volume of hardware and the cost were the two biggest disadvantages of this technology. As communication measures are getting more and more important, discussion in this field is becoming more and more necessary. In this paper, multiple technologies would be discussed from the angles of principle, current situation, and advantages and flaws. Next, these technologies would be discussed under different scenarios that could be faced in the daily life of common people, industrial fields and other uses, then compared from several perspectives to select the one that fits the situation best.

High blood concentrations of nonesterified fatty acids (NEFAs) provoke various metabolic disorders and are associated with mammary tissue injury and decreased milk production in dairy cows. Nuciferine, an alkaloid found in

Abernethy malformation, also known as congenital extrahepatic shunt, is a rare anomaly characterized by partial or complete diversion of the portal blood into the systemic venous circulation. The clinical manifestations of Abernethy malformation during childhood include neonatal cholestasis, failure to thrive, mental retardation, and other congenital defects. We report a case of Abernethy malformation Type Ⅱ in a 9-year-old boy whose left ventricle was slightly enlarged because of several major aortopulmonary collateral arteries but normal laboratory examinations five years earlier. The characteristics of congenital heart disease in patients with Abernethy malformation are discussed. We propose that enlargement of the left ventricular with systemic-pulmonary collateral circulation should raise the suspicion of Abernethy malformation.

We report on studying tunnel junctions and an optical cavity structure for developing epitaxially-stacked high-efficiency 905 nm high-power laser diodes. The GaAs tunnel junctions were explored via simulations and experiments to realize a high peak current density of 7.7 × 104 A/cm2 and a low specific resistance of 1.5 × 10-5 Ωcm2 with a high n-doping concentration of 6 × 1019 cm-3. Employing a low-loss epitaxial structure design, single-, double-, and triple-cavity structure laser diodes demonstrated power scaling by epitaxial stacking. Triple-cavity laser diodes have a low optical loss (0.42 cm-1) and generate a peak power of 83 W with a short cavity length of 750 μm at a limited current of 30 A. © 2009-2012 IEEE.

Surface ozone concentrations typically peak during the daytime, driven by active photochemical production, and decrease gradually after sunset, due to chemical destruction and dry deposition. Here, we report that nocturnal ozone enhancement (NOE, defined as an ozone increase of more than 5 ppbv h−1 in 1 of any 2 adjacent hours between 20:00 and 06:00 LT, local time) events are observed at multiple monitoring sites in China at a high frequency, which has not been recognized in previous studies. We present an overview of the general characteristics of NOE events in China and explore the possible mechanisms based on 6 years of observations from the national monitoring network. We find that the mean annual frequency of NOE events is 41±10 % (i.e., about 140 d would experience an NOE event per year) averaged over all 814 Chinese sites between 2014 and 2019, which is 46 % larger than that over Europe or the United States. The NOE event frequency is higher in industrialized city clusters (>50 %) than in regions with lighter ozone pollution, and it is higher in the warm season (46 %) than in the cold season (36 %), consistent with the spatiotemporal evolution of ozone levels. The mean ozone peak during NOE events reaches 37±6 ppbv in the warm season. The ozone enhancements are within 5–15 ppbv h−1 during 85 % of the NOE events; however, in about 10 % of cases, the ozone increases can exceed 20 ppbv h−1. We propose that high photochemistry-induced ozone during the daytime provides a rich ozone source in the nighttime residual layer, determining the overall high frequency of NOE events in China, and that enhanced atmospheric mixing then triggers NOE events by allowing the ozone-rich air in the residual layer to mix into the nighttime boundary layer. This is supported by our analyses which show that 70 % (65 %) of the NOE events are associated with increases in friction velocity (planetary boundary layer height), indicative of enhanced atmospheric mixing, and also supported by the observed sharp decreases in surface NO2 and CO concentrations with ozone increases in NOE events, a typical signal of mixing with air in the residual layer. Three case studies in Beijing and Guangzhou show that synoptic processes such as convective storms and low-level jets can lead to NOE events by aggravating vertical mixing. Horizontal transport of ozone-rich plumes may also be a supplementary driver of NOE events. Our results summarize, for the first time, the characteristics and mechanism of NOE events in China based on nationwide and long-term observations, and our findings emphasize the need for more direct measurements and modeling studies on the nighttime ozone evolution from the surface to the residual layer.

Gangliogliomas are uncommon intracranial tumors that include neoplastic and abnormal ganglion cells, and show positive immunohistochemical staining for GFAP and syn. This type of lesion occurs more frequently in the temporal lobe than in other areas; they are extremely rare in the suprasellar region. To the best of our knowledge, including our case, 19 cases of GGs have been found in the suprasellar region. Among them, five tumors invaded the optic nerve, nine tumors invaded the optic chiasm, one tumor invaded the optic tract, and two tumors invaded the entire optic chiasmal hypothalamic pathway. In the present study, we describe the first case of suprasellar GGs arising from the third ventricle floor that was removed through the endoscopic endonasal approach. In addition, we summarize the clinical characteristics of GGs, such as age of onset, gender distribution, MRI signs, main clinical symptoms, and treatment methods for GG cases.

Cancer therapies usually suffer from poor targeting ability and serious side effects. Photoactivatable cancer therapy has the significant advantage of a high spatiotemporal resolution, but most photoactivatable prodrugs require decoration with stoichiometric photocleavable groups, which are only responsive to ultraviolet irradiation and suffer from low reaction efficiency. To tackle these challenges, we herein propose a photoactivation strategy with biogenic riboflavin as the photosensitizer to promote the in situ transformation of noncytotoxic dihydroalkaloid prodrugs dihydrochelerythrine (DHCHE), dihydrosanguinarine (DHSAN), and dihydronitidine (DHNIT) into anticancer alkaloid drugs chelerythrine (CHE), sanguinarine (SAN), and nitidine (NIT), respectively, which can efficiently kill cancer cells and inhibit in vivo tumor growth. Meanwhile, the photoactivatable transformation can be in situ monitored by green-to-red fluorescence conversion, which will contribute to easy controlling of the therapeutic dose. The proposed photoactivatable transformation mechanism was also explored by density functional theory (DFT) calculations. We believe this riboflavin-promoted and imaging-guided photoactivation strategy is promising for precise cancer therapy.