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Objective To assess the long-term effectiveness and safety of trastuzumab in adjuvant therapy for Chinese patients with early-stage human epidermal growth factor 2 (HER2)-positive breast cancer in a real-world setting. Methods This retrospective observational study analyzed the medical records of HER2-positive breast cancer patients between 2000 and 2012 at the Chinese Academy of Medical Sciences. Patients who received adjuvant chemotherapy alone or adjuvant chemotherapy followed by/combined with trastuzumab were included. The Kaplan-Meier method was used to estimate disease-free survival (DFS) and overall survival (OS). Hazard ratios (HR) and 95% confidence intervals (95% CI) were calculated using the Cox regression model. Results Of the 1,348 patients analyzed, 909 received chemotherapy alone and 439 received chemotherapy plus trastuzumab. The 3-year, 5-year and 10-year DFS rates were 83.70%, 76.38% and 68.94%, respectively, in the chemotherapy-alone cohort, and 90.21%, 86.19% and 83.45% in the chemotherapy plus trastuzumab cohort. The 3-year, 5-year and 10-year OS rates were 96.10%, 91.40% and 81.88% in the chemotherapy-alone cohort, and 98.17%, 94.91% and 90.01% in the chemotherapy plus trastuzumab cohort. The chemotherapy plus trastuzumab group had a significantly lower risk of disease recurrence and death than the chemotherapy-alone group (DFS: HR=0.50, 95% CI, 0.37-0.68; P

During the measurement and analysis of Micro Total Analysis System (-TAS), the bulk of the injected sample is about nano-liter, so that the study of microfluidic sensor has been becoming an important aspect of the analytical instrument. The microfluidic sensor based on the principle of the thermal distribution could be used to measure the micro flow by measuring the asymmetry of temperature profile around the heater. The precision of micro flow measurement depends on the precise of the temperature measurement. Ni thin film was chosen as the material of the temperature sensor, and it was sputtered on different substrates by dc magnetron method. The adhesion between Ni thin film and different substrates were investigated by EPMA (Electron Probe Micro Analyzer). The results indicate that nickel thin film can be used as a suitable material for fabricating temperature sensor, and the arrangement order of the adhesion between Ni thin film and wafer are Si3N4/SiO2/Si, SiO2/Si and Si, respectively. The TCR of the Ni thin film temperature sensor fabricated in this paper is about 6.3 × 10 −3 ◦ C −1 , which has satisfied the requisition of microfluidic sensor, and it could be used in many fields. © 2006 Elsevier B.V. All rights reserved.