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Carbonic anhydrase IX (CA IX) and, to a lesser extent. carbonic anhydrase XII (CA XII) are highly overexpressed in hypoxic tumors. In this study, the inhibitory effects of 11 different anticancer drugs including paclitaxel, amethopterin, etoposide, irinotecan, gemcitabine, 5-fluorouracil, oxaliplatin, epirubicin, cisplatin and carboplatin on the tumor-associated carbonic anhydrase isozymes CA IX and CA XII and cytosolic carbonic anhydrases I and II have been investigated. SX. 18MV-R Applied Photophysics stopped-flow instrument was used for measuring the initial velocities for the CO, hydration reaction catalyzed by different CA isozymes. by following the change in the absorbance of a pH indicator CA IX and CA XII were the Most affected by carboplatin and cisplatin amongst the panel of anticancer drugs. Moreover, the cytosolic carbonic anhydrases I and H can also be affected. Consequently, CA IX and CA XII are interesting targets for anticancer drug development, although more selective and powerful CA inhibitors could prove useful for elucidating the role of the protein in hypoxic cancers, for controlling the pH imbalance in tumor cells and for developing diagnostic or therapeutic applications for the management of hypoxic tumors, generally unresponsive to classical chemo- and radiotherapy Copyright 2008 Prous Science. S.A.U. or its licensors. All rights reserved.

BACKGROUND/AIMS: It has been shown that systemic bacteremia and endotoxemia in peritonitis is mainly related to lymphatic transport via the thoracic duct. This study was performed to investigate the effect on mortality of thoracic duct ligation in experimental peritonitis.

Functional movement deficiencies cause falls and injuries in adults. Functional strength training (FST) is emerging as a new training method for athletes, middle-aged and older adults, to improve functional movement: The present study was conducted in order to investigate the effects of FST on balance and functional movement in healthy and independent middle-aged adults. The sample for this study consisted of 46 physically active individuals (24 female and 22 male). A total of 46 subjects were divided based on randomly into the functional strength training (FST) group (n = 26) aged: 51.55 ± 3.73 years; height: 168.69 ± 8.8 cm; body mass: 75.88 ± 12.18; and traditional strength training (TST) group (n = 20) age: 52.85 ± 4.01; height: 166.9 ± 9.98; body mass: 76.15 ± 10.45. Each group performed 24 sessions of a training protocol three-time a week. The functional movement was assessed using the functional movement screen (FMS) protocol. Balance performance was determined by using the balance error scoring system (BESS). Bodyweight and body fat ratio were measured using bioelectric impedance. There was a significant statistical difference between FMS total scores after an eight-week FST in the FST group. After the intervention, the functional strength group tended to have significantly better balance control than the traditional strength group (p = 0.01). Statistically, significant differences were observed between pre-test and post-test in the intervention group on BMI, body fat, and body mass (p = 0.01). There were not found significant differences in balance control and FMS score in TST group. As a result of this study, FST positively affected the FMS total score and balance performance in middle-aged adults. Early detections of the deficiencies in functional movement and balance in the middle ages may reduce the risk of insufficiency and fall in adults through targeted functional strength training intervention.

Background: Physical fitness in youth is a predictor of health in adulthood. The main objective of the present study was to understand if an enriched sport activity program could increase physical fitness in a population of schoolchildren. Methods: In a sample of 672 children aged 10.0 &plusmn, 1.90 years, different motor skills were tested by the 1 kg and 3 kg ball throw (BT), the standing broad jump (SBJ), the 30 m sprint (30mS), the leger shuttle run (LSR), the illinois agility test (IGT), and the quadruped test (QT). Within the controlled-trial, the intervention group (ESA) underwent an additional warm-up protocol, which included cognitive enhancing elements, for 14 weeks while the control group continued with ordinary exercise activity. Results: A significant increase was present regarding the 1 kg and 3 kg BT, the SBJ, the 30mS, and the IGT, while no significant difference was shown regarding the QT and the LSR in the ESA group between pre and post intervention. In the control group, no differences were present for any test except for the QT and the LSR post-test. Conclusion: A 14-week structured physical intervention had moderate effects regarding throwing, jumping, sprinting, and agility in a sample of schoolchildren.