Cancer-related genomic services (hereafter CRGS), are defined as clinical services including risk assessment for hereditary cancer risk, cancer genetic education or counseling, cancer genetic testing, and have impacted current cancer prevention strategies, treatment options, and patient care.1 For example, brief family history assessments endorsed by national (e.g., USPSTF) and public health organizations (e.g., CDC) now enable low-cost population-based screening to identify families at high risk for BRCA-associated cancers.2-4 Implementing this cancer screening is critical as women who carry a BRCA1/2 mutation have significantly increased lifetime risks for breast (50-80%) and ovarian cancer (10-40%).5-6 Life-saving prevention and treatment options are available to mutation carriers. 5-6 Unfortunately, current efforts to expand cancer genetic screening beyond urban cancer specialty settings that serve predominantly non-Hispanic white have been exceedingly slow and will likely lead to further entrenchment of health disparities.7-10 Cancer-related genetic risk screening has notable benefits particularly relevant for Latinos and Hispanic people (hereafter referred to as “Latinx”). Latinx is a gender-neutral term for Latino/a and signifies unity, coalition, and inclusivity among the heterogenous population.11 Compared to non-Hispanic Whites, Latinas are often diagnosed with breast cancer at younger ages and with tumor types (e.g., triple-negative disease) linked to hereditary genetic mutations.12-15 However, Spanish-speaking Latinas are half as likely as Whites to have discussed genetic counseling or testing with a health provider.10, 16 Several complexities must be considered when deciding how to best analyze the current literature on interventions designed to increase the uptake of cancer-related genomic services for Latinx communities in the United States. First, acculturation has documented positive results in Latinx populations and their health care use, uptake of cancer screening services, and self-perception of health.17 Acculturation is measured by factors such as socioeconomic status, educational level, language fluency, immigration status, and time/number of generations living in the United States.17 Second, current interventions increasing the uptake of CRGS are not classified by defining characteristics, such as whether the intervention was evidence-based, if adaptations to the intervention were made for Latinx individuals, or additional services offered to increase uptake (medical information in English and Spanish, minimizing cost of testing, transportation options available, etc.). Categorizing current interventions using the RE-AIM framework can allow for consistent reporting of research outcomes and help future organizations in implementing interventions that can maximize uptake of CRGS among Latinx populations. In order to understand how the heterogeneity of the Latinx community impacts the uptake of cancer screening services, a scoping review on interventions for uptake of cancer-related genomic services in the United States and Latin America will be conducted. Since acculturation can vary based on immigration experiences, education, and country of origin, this scoping review will address the current gap in literature in assessing differences in acculturation within the Latinx community, communication efforts among Latinx populations, and uptake of health services. Additionally, the goal of this study is to categorize interventions within the United States and Latin America by type to identify successful intervention strategies, areas of improvement, and understand the nature of interventions Latinx populations experience abroad as well as in the United States.