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Supplemental material, sj-pdf-1-vmj-10.1177_1358863X211033649 for Exercise therapy referral and participation in patients with peripheral artery disease: Insights from the PORTRAIT registry by Tripti Gupta, Patrick Manning, Dhaval Kolte, Kim G Smolderen, Nancy Stone, Jessica G Henry, Jingyan Wang, Kensey L Gosch, Christopher J White, John Spertus and J Dawn Abbott in Vascular Medicine

Supplemental material, sj-pdf-1-vmj-10.1177_1358863X211033649 for Exercise therapy referral and participation in patients with peripheral artery disease: Insights from the PORTRAIT registry by Tripti Gupta, Patrick Manning, Dhaval Kolte, Kim G Smolderen, Nancy Stone, Jessica G Henry, Jingyan Wang, Kensey L Gosch, Christopher J White, John Spertus and J Dawn Abbott in Vascular Medicine

Supplemental material, sj-docx-1-vmj-10.1177_1358863X211033649 for Exercise therapy referral and participation in patients with peripheral artery disease: Insights from the PORTRAIT registry by Tripti Gupta, Patrick Manning, Dhaval Kolte, Kim G Smolderen, Nancy Stone, Jessica G Henry, Jingyan Wang, Kensey L Gosch, Christopher J White, John Spertus and J Dawn Abbott in Vascular Medicine

This study sought to describe the association between chronic total occlusion (CTO) revascularization (CTO percutaneous coronary intervention [PCI]) and health status in patients with and without cardiomyopathy.Prior PCI trials for cardiomyopathy have excluded CTO patients. Whether patients with reduced left ventricular ejection fraction (LVEF) receive similar health status benefit from CTO-PCI compared with patients with normal LVEF is unclear.We assessed health status change, using the Seattle Angina Questionnaire (SAQ) Summary, SAQ Angina Frequency, and Rose Dyspnea Scale scores, among patients undergoing successful CTO PCI in the OPEN-CTO (Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion) Registry. Participants were classified by LVEF (normal, ≥50%; mild-moderate, 30% to 49%; and severe, 30%), with higher SAQ and lower Rose Dyspnea Scale scores indicating better health status. Differences in 1-year outcomes were compared using hierarchical multivariable regression.Of 762 patients, 506 (66.4%), 193 (25.3%), and 63 (8.3%) had normal, mild-moderate, and severely reduced LVEF. SAQ Summary score improvements were observed in each group (27.1 ± 20.4, 26.7 ± 21.2, and 20.3 ± 18.1, respectively). Compared with patients with LVEF ≥50%, those with LVEF 30% had less improvement in SAQ Summary Score (-5.2 points; 95% confidence interval: -9.0 to -1.5; p = 0.01) and Rose Dyspnea Scale (+0.5 points; 95% confidence interval: 0.1 to 0.8; p = 0.01), with no difference in odds of angina (odds ratio: 1.3; 95% confidence interval: 0.6 to 3.0; p = 0.48). Health status improvement was similar between patients with LVEF ≥50% and LVEF 30% to 49%.Although health status improvement was less in patients with severely reduced LVEF compared with those with normal LVEF, each group experienced large health status improvements after CTO-PCI.