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OBJECTIVES: The aim of the study was to assess clinical presentation, endoscopic findings, antibiotic susceptibility and treatment success of Helicobacter pylori (H. pylori) infected pediatric patients. METHODS: Between 2013 and 2016, 23 pediatric hospitals from 17 countries prospectively submitted data on consecutive H. pylori-infected (culture positive) patients to the EuroPedHP-Registry. RESULTS: Of 1333 patients recruited (55.1% girls, median age 12.6 years), 1168 (87.6%) were therapy naïve (group A) and 165 (12.4%) had failed treatment (group B). Patients resided in North/Western (29.6%), Southern (34.1%) and Eastern Europe (23.0%), or Israel/Turkey (13.4%). Main indications for endoscopy were abdominal pain or dyspepsia (81.2%, 1078/1328). Antral nodularity was reported in 77.8% (1031/1326) of patients, gastric or duodenal ulcers and erosions in 5.1% and 12.8%, respectively. Primary resistance to clarithromycin (CLA) and metronidazole (MET) occurred in 25% and 21%, respectively, and increased after failed therapy. Bacterial strains were fully susceptible in 60.5% of group A, but in only 27.4% of group B. Primary CLA resistance was higher in Southern and Eastern Europe (adjusted odds ratio [ORadj] = 3.44, 95% confidence interval [CI] 2.22-5.32, P, SCOPUS: ar.j, info:eu-repo/semantics/published

The presentation will describe the project “Emerging Narratives on the Inclusive School from the Social Model of Disability: Resistance, resilience and social change”. The project aims to dismantle forms of oppression at the personal, relational, and structural levels through (a) life histories of people experiencing intersecting forms of oppression and (b) action-oriented narratives for the expansion of collective imaginations. In particular, the paper presents Sandra's life story (experiencing oppression at the intersections of disability, transgender, and drug addiction), the process of building a campaign for inclusive education generated by activist families, and the work of a very diverse group of students that generates proposals for other students to promote inclusion in their own schools. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.

Introduction: The COVID-19 pandemic has had detrimental impacts in non-rural Black and rural Appalachian populations. Yet despite the pandemic’s magnitude, there is a scarcity of research exploring potential influences of attitudes and social influences within these populations on their adherence to COVID-19 public health preventive behaviors. Purpose: This study examines the intention, attitudes, and social influences to adhere to COVID-19 preventive behaviors among non-rural Black and rural Appalachian congregants in Kentucky by integrating the Theory of Planned Behavior (TPB). Methods: Secondary analysis of cross-sectional data was used to assess the association between the TPB constructs and four key public health behaviors: obeying a stay-at-home order, social distancing, good hygiene practices, and wearing a mask in public. Generalized estimating equation-type logistic regression models were fit for all binary outcomes. Results: A total of 942 respondents completed the survey. Eighty-nine per cent were older than 36 years, and 73% were female. Of the respondents who were White, 97.7% lived in rural Appalachia Kentucky, and of those who were Black, 93.5% lived in non-rural Kentucky. Attitude towards the behavior was negatively associated with the stay-at-home order (p=0.003). Both attitude toward the behavior (p

Prenatal alcohol exposure (PAE) has been linked to neurological, behavioural, cognitive, and emotional problems. The neurocognitive impairments identified in individuals with PAE are prevalent and have a major impact on the quality of life of individuals living with the effects of PAE. Understanding the structural connectivity that underpins these neurocognitive deficits is crucial for furthering our understanding of PAE. This thesis aims to examine the relationships between frontoparietal and temporal white matter as assessed by diffusion tensor imaging (DTI) tractography, neurocognitive abilities, and age-related changes in children and youth with PAE. DTI was obtained from 31 participants with PAE and 31 unexposed controls aged 7-15 years. Mean diffusivity (MD) and fractional anisotropy (FA) were derived from tractography of the genu, body, and splenium of the corpus callosum (CC), bilateral cingulum, inferior longitudinal fasciculus (ILF), and superior longitudinal fasciculus (SLF). All participants completed three language subtests from the NEPSY-II. Executive functioning was measured using the Behavior Rating Inventory of Executive Functioning-Parental Report (BRIEF-PR), and verbal learning was assessed using the California Verbal Learning Test-Children's Version (CVLT-C) in the children with PAE only. The data presented in this thesis showed lower mean diffusivity values in the right superior longitudinal fasciculus in children and youth with PAE compared to unexposed peers. This cross-sectional analysis revealed positive linear correlations of fractional anisotropy versus age in white matter tracts except the genu of the corpus callosum, the right and left inferior longitudinal fasciculus, and negative linear correlations of mean diffusivity versus age in all white matter tracts. However, there were no significant age-group interactions. In addition, there were no significant associations between MD or FA of the tracts with age-standardized cognitive scores in either unexposed controls or children with PAE who scored lower than unexposed peers in language subtests and below population norms in tests that assess executive functioning and verbal learning. This thesis provides evidence of group differences in mean diffusivity of only one frontoparietal tract, the SLF, in children and youth with PAE, although these changes were not correlated to cognitive disability. Steeper decreases in mean diffusivity values with age have been observed in the SLF in children with PAE in previous research. This project also contributes to the existing limited literature that has identified similar age-related changes of diffusion metrics in white matter tracts in participants with PAE and typically developing peers, suggesting normative neurodevelopment in individuals with PAE.

The impact of exposure to astrophysical ionizing radiation on astronaut health is one of the main concerns in planning crewed missions to Mars. Astronauts will be exposed to energetic charged particles from Galactic and Solar origin for a prolonged period with little protection from a thin spacecraft shield in transit and from the rarefied Martian atmosphere when on the surface. Adverse impacts on astronaut health include, for example, Acute Radiation Syndrome, damage to the nervous system, and increased cancer risk. We rely on medical studies to assess the impact of enhanced radiation dose levels on various physiological systems and the overall health of astronauts. Using a combination of radiation measurements and numerical modeling with the GEANT4 package, we calculate the distribution of radiation dose in various human body organs for various expected scenarios simulated with a model human phantom. We suggest mitigation strategies, such as improved ways of shielding and dietary supplements, and make recommendations for the safety of astronauts in future crewed missions to Mars., Comment: Under Review

P. aeruginosa infections, like those caused by many other hospital bacteria, are becoming more difficult to treat because of the increasing development of antibiotic resistance processes and the fewer new antibiotics that are being developed. Currently the gold standard technology for diagnosis of infections is based on sample plate cultures, which have several limitations regarding sensitivity, especially in the case of previous antimicrobial therapy. In this context, we have developed a highly sensitive, specific and reliable immunochemical assay to detect pyocyanin (PYO), the most important virulence factor of P. aeruginosa. The assay uses a high affinity monoclonal antibody raised against the precursor 1-hydroxyphenazine (1-OHphz) hapten derivatives. PYO is a redox-active phenazine responsible of the characteristic blue-green color of these bacteria that has been demonstrated to induce neutrophil apoptosis, interleukin release and weakness of the immune system. The microplate-based ELISA developed is able to achieve a LoD of 0.07 nM which is much below the concentrations reported to be found in clinical samples (130 ¿M in sputa and 2.8 ¿M in ear secretions To our knowledge does not exist in the market any rapid and specific diagnostic kit to detect this biomarker. Thus, the validation of this assay from a clinical perspective would render a faster, reliable diagnostic tool, opening the possibility to apply more appropriate specific treatment, reducing adverse effects and the development of antimicrobial resistance mechanisms. With this aim, the tasks included in this valorization project have included the assessment of PYO as biomarker of P. aeruginosa respiratory infections and the validation of the immunoassay for its detection. Moreover, the market and the need for an in vitro diagnostic (IVD) method have be evaluated, studying the possible commercialization of this assay implemented as a point of care device.

Abstract:: The diagnosis of sacral neoplasms is often delayed because they tend to remain clinically silent for a long time. Imaging is useful at all stages of the management of sacral bone tumors, i.e., from the detection of the neoplasm to the long-term follow-up. Radiographs are recommended as the modality of choice to begin the imaging workup of a patient with known or suspected sacral pathology. More sensitive examinations, such as Computerized Tomography (CT), magnetic resonance (MRI), or scintigraphy, are often necessary. The morphological features of the lesions on CT and MRI help orientate the diagnosis. Although some imaging characteristics are helpful to limit the differential diagnosis, an imaging-guided biopsy is often ultimately required to establish a specific diagnosis. Imaging is of paramount importance even in the long-term follow-up, in order to assess any residual tumor when surgical resection remains incomplete, to assess the efficacy of adjuvant chemotherapy and radiotherapy, and to detect recurrence.

Purpose To describe an evaluation conducted by 39 state EHDI programs on how acceptable the reporting process and system audiologists had to use when reporting the hearing test results to the EHDI program and the barriers encountered during reporting. Methods Each author independently extracted numbers, percentages, and texts from the evaluation reports into an Excel spreadsheet, which then became the dataset. Authors then compared and cross-checked the datasets before coding. Texts conveying similar concepts were coded with the same name and organized into categories. Finally, thematic identification and analysis were performed when a theme(s) or concept(s) that pertained to similar challenges encountered by audiologists was identified and organized under a higher-order domain. Results Some audiologists reported no barriers when reporting hearing test results to the state EHDI programs. Among those audiologists who reported barriers, the most recurrent barrier was a non-user-friendly data system design. The second most recurrent barrier was not having adequate administrative time to report data as a busy clinician. The third most recurrent barrier was an incomplete understanding of the state EHDI reporting requirements. Finally, the method audiologists were required to use when reporting results also posed some challenges, such as no internet connection in rural areas when required to report via an internet portal. Conclusion: Because of the wide variety of barriers faced by audiologists, multiple strategies to improve the reporting process would likely be beneficial. Keywords: reporting hearing result, EHDI program, barriers to reporting, audiologist

Biomarcadores; Fenotipo clásico; Enfermedad de Fabry Biomarkers; Classic phenotype; Fabry disease Biomarcadors; Fenotip clàssic; Malaltia de Fabry Fabry disease (FD) is a lysosomal storage disorder caused by deficient alpha-galactosidase A activity in the lysosome due to mutations in the GLA gene, resulting in gradual accumulation of globotriaosylceramide and other derivatives in different tissues. Substrate accumulation promotes different pathogenic mechanisms in which several mediators could be implicated, inducing multiorgan lesions, mainly in the kidney, heart and nervous system, resulting in clinical manifestations of the disease. Enzyme replacement therapy was shown to delay disease progression, mainly if initiated early. However, a diagnosis in the early stages represents a clinical challenge, especially in patients with a non-classic phenotype, which prompts the search for biomarkers that help detect and predict the evolution of the disease. We have reviewed the mediators involved in different pathogenic mechanisms that were studied as potential biomarkers and can be easily incorporated into clinical practice. Some accumulation biomarkers seem to be useful to detect non-classic forms of the disease and could even improve diagnosis of female patients. The combination of such biomarkers with some response biomarkers, may be useful for early detection of organ injury. The incorporation of some biomarkers into clinical practice may increase the capacity of detection compared to that currently obtained with the established diagnostic markers and provide more information on the progression and prognosis of the disease. The research has not received any external funding.

ObjectivesDietary supplements may ameliorate SARS-CoV-2 infection, although scientific evidence to support such a role is lacking. We investigated whether users of the COVID-19 Symptom Study app who regularly took dietary supplements were less likely to test positive for SARS-CoV-2 infection.DesignApp-based community survey.Setting445 850 subscribers of an app that was launched to enable self-reported information related to SARS-CoV-2 infection for use in the general population in the UK (n=372 720), the USA (n=45 757) and Sweden (n=27 373).Main exposureSelf-reported regular dietary supplement usage (constant use during previous 3 months) in the first waves of the pandemic up to 31 July 2020.Main outcome measuresSARS-CoV-2 infection confirmed by viral RNA reverse transcriptase PCR test or serology test before 31 July 2020.ResultsIn 372 720 UK participants (175 652 supplement users and 197 068 non-users), those taking probiotics, omega-3 fatty acids, multivitamins or vitamin D had a lower risk of SARS-CoV-2 infection by 14% (95% CI (8% to 19%)), 12% (95% CI (8% to 16%)), 13% (95% CI (10% to 16%)) and 9% (95% CI (6% to 12%)), respectively, after adjusting for potential confounders. No effect was observed for those taking vitamin C, zinc or garlic supplements. On stratification by sex, age and body mass index (BMI), the protective associations in individuals taking probiotics, omega-3 fatty acids, multivitamins and vitamin D were observed in females across all ages and BMI groups, but were not seen in men. The same overall pattern of association was observed in both the US and Swedish cohorts.ConclusionIn women, we observed a modest but significant association between use of probiotics, omega-3 fatty acid, multivitamin or vitamin D supplements and lower risk of testing positive for SARS-CoV-2. We found no clear benefits for men nor any effect of vitamin C, garlic or zinc. Randomised controlled trials are required to confirm these observational findings before any therapeutic recommendations can be made.

Bacillus cereus es una especie bacteriana con miembros que pueden causar intoxicaciones en humanos fundamentalmente por la ingesta de alimentos contaminados. Estudios previos han demostrado la importancia de la esporulación en el ciclo de vida de B. cereus, sin embargo, poco se sabe sobre cómo la formación de biopelículas y la adquisición de factores de virulencia por transferencia horizontal de genes, afecta en la ecología de esta bacteria. En esta tesis hemos demostrado que cepas asporogénicas de B. cereus no persisten en huéspedes hostiles como la hoja de melón, sin embargo, sí que lo hacen en plantas ricas en nutrientes como la endivia, donde esta bacteria es capaz de sobrevivir a altas concentraciones en su forma vegetativa. Además, hemos encontrado que la esporulación no es estrictamente necesaria para causar trastornos intestinales en un hospedador mamífero. Por otro lado, hemos visto que los componentes de la biopelícula de B. cereus juegan un papel relevante en la colonización y distribución de la bacteria sobre hojas de plantas, siendo importante la influencia de la topografía y composición metabólica del huésped en el perfil de expresión de los componentes de la biopelícula. Finalmente, durante el desarrollo de esta tesis se identificó un morfotipo derivado de una cepa de B. cereus que, mediante la escisión y replicación de un profago en su citoplasma, es capaz de modular su fenotipo, convirtiéndose en una cepa más virulenta y siendo capaz de causar enfermedades de curso agudo e incluso la muerte del hospedador.

La vulneración del derecho a la educación del sistema educativo español es una realidad denunciada por reconocidos organismos internacionales. De ahí la necesidad de perfilar líneas de acción contra la exclusión y segregación escolar, principal objetivo del workshop celebrado en la Universidad de Málaga (España) en el marco de un proyecto de investigación nacional sobre educación inclusiva (RTI2018-099218-A-I00). Este evento, al que acudieron más de cien personas pertenecientes a la comunidad educativa (familias, profesionales y alumnado), sirvió de punto de encuentro para discutir cómo se aplica el principio de equidad al alumnado con discapacidad en nuestro sistema escolar. El análisis cualitativo del diálogo surgido durante este encuentro ha servido para realizar un diagnóstico de la situación, buscando arrojar luz sobre algunos de los factores que intervienen en la segregación escolar y favorecen su reproducción, así como sobre los efectos que produce.

The installation of electric vehicle charging stations (EVCS) will be essential to promote the acceptance by the users of electric vehicles (EVs). However, if EVCS are exclusively supplied by the grid, negative impacts on its stability together with possible CO2 emission increases could be produced. Introduction of hybrid renewable energy systems (HRES) for EVCS can cope with both drawbacks by reducing the load on the grid and generating clean electricity. This paper develops a methodology based on a weighted multicriteria process to design the most suitable configuration for HRES in EVCS. This methodology determines the local renewable resources and the EVCS electricity demand. Then, taking into account environmental, economic and technical aspects, it deduces the most adequate HRES design for the EVCS. Besides, an experimental stage to validate the design deduced from the multicriteria process is included. Therefore, the final design for the HRES in EVCS is supported not only by a complete numerical evaluation, but also by an experimental verification of the demand being fully covered. Methodology application to Valencia (Spain) proves that an off-grid HRES with solar PV, wind resources and batteries support would be the most suitable configuration for the system. This solution was also experimentally verified.

Background: The prospective phase IV AVAMET study was undertaken to correlate response evaluation criteria in solid tumors (RECIST)-defined response rates with computed tomography-based morphological criteria (CTMC) and pathological response after liver resection of colorectal cancer metastases. Methods: Eligible patients were aged &ge, 18 years, with Eastern Cooperative Oncology Group (ECOG) performance status 0/1 and histologically-confirmed colon or rectal adenocarcinoma with measurable liver metastases. Preoperative treatment was bevacizumab (7.5 mg on day 1) + XELOX (oxaliplatin 130 mg/m2, capecitabine 1000 mg/m2 bid on days 1&ndash, 14 q3w). After three cycles, response was evaluated by a multidisciplinary team. Patients who were progression-free and metastasectomy candidates received one cycle of XELOX before undergoing surgery 3&ndash, 5 weeks later, followed by four cycles of bevacizumab + XELOX. Results: A total of 83 patients entered the study, 68 were eligible for RECIST, 67 for CTMC, and 51 for pathological response evaluation. Of these patients, 49% had a complete or partial RECIST response, 91% had an optimal or incomplete CTMC response, and 81% had a complete or major pathological response. CTMC response predicted 37 of 41 pathological responses versus 23 of 41 responses predicted using RECIST (p = 0.008). Kappa coefficients indicated a lack of correlation between the results of RECIST and morphological responses and between morphological and pathological response rates. Conclusion: CTMC may represent a better marker of pathological response to bevacizumab + XELOX than RECIST in patients with potentially-resectable CRC liver metastases.

Scope Jurisdictional-based Early Hearing Detection and Intervention Information Systems (EHDI-IS) collect data on the hearing screening and follow-up status of infants across the United States. These systems serve as tools that assist EHDI programs’ staff and partners in their tracking activities and provide a variety of data reports to help ensure that all children who are deaf/hard of hearing (D/HH) are identified early and receive recommended intervention services. The quality and timeliness of the data collected with these systems are crucial to effectively meeting these goals. Methodology Forty-eight EHDI programs, funded by the Centers for Disease Control and Prevention (CDC), successfully evaluated the accuracy, completeness, uniqueness and timeliness of the hearing screening data as well as the acceptability (i.e. willingness to report) of the EHDI-IS among data reporters (2013-2016). This article describes the evaluations conducted and presents the findings from these evaluation activities. Conclusions: Most state EHDI programs are receiving newborn hearing screening results from hospitals and birthing facilities in a consistent way and data reporters are willing to report according to established protocols. However, additional efforts are needed to improve the accuracy and completeness of reported demographic data, results from infants transferred from other hospitals, and from infants admitted to the Neonatal Intensive Care Unit.

El alto nivel de desempleo es uno de los principales problemas económicos de España, con una situación notablemente peor en los últimos años que en otros países desarrollados. En septiembre de 2017, según datos de Eurostat, la tasa de paro española destacaba en el contexto europeo con un 16,5%, muy por encima de la media del 7,9%, y sólo por debajo de la de Grecia. Pese a la evolución positiva tras el máximo del 27% en 2013, la economía sigue lejos de la situación de 2007, antes del comienzo de la crisis, en la que una tasa de paro del 8,2% se situaba apenas un punto por encima de la media europea. Las diferencias, sin embargo, son menores si se mide el rendimiento del mercado de trabajo mediante la tasa de empleo, que a mediados de 2017 era en España de un 61,1%, frente a una media del 66,7%. Estos datos llevan a plantearse si esta elevada tasa de paro responde a dificultades generalizadas para encontrar empleo para todos los trabajadores por igual, o si bien existen diferencias entre distintos grupos, en función de características socioeconómicas como el nivel educativo, el género o la edad de los activos, entre otras. El presente trabajo utiliza datos de la EPA desde 2005 hasta 2017 para analizar cómo las características individuales de los trabajadores afectan a la probabilidad de que estén parados frente a ocupados, y cómo tales efectos han evolucionado desde el comienzo de la crisis. Los resultados permiten identificar los grupos con mayores problemas de desempleo y qué colectivos han encontrado mayores dificultades relativas para acceder al empleo en los últimos años. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.

Objective To determine the incidence and risk factors of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD). Methods Analysis of data after 2.5 years of follow-up from the prospective study CARMA project, that includes patients with CIRD [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA)] and matched individuals without CIRD from 67 hospitals in Spain. CVE cumulative incidence per 1000 patients was calculated after 2.5 years from the start of the project. Weibull proportional hazard model was used to calculate hazard ratio (HR) and 95% confidence interval (95% CI) of the risk factors. Results 2595 (89.1%) patients completed the 2.5 years of follow-up visit. Cumulative incidence of CVE in patients with CIRD was 15.30 cases per 1000 patients (95% CI: 12.93-17.67), being higher in the subgroup with AS; 22.03 (95% CI: 11.01-33.04). Patients with AS (HR: 4.11; 95% CI: 1.07-15.79), those with older age (HR: 1.09; 95% CI: 1.05-1.13), systolic hypertension (HR: 1.02; 95% CI: 1.00-1.04) and long duration of the disease (HR: 1.07; 95% CI: 1.03-1.12) were at higher risk of first CVE during the 2.5 years of follow-up. In contrast, female gender was a protective factor (HR: 0.43; 95% CI: 0.18-1.00). Conclusion Among CIRD patients prospectively followed-up at rheumatology outpatient clinics, those with AS show higher risk of first CVE. Besides cardiovascular risk factors, such as hypertension, being a man and older

The aim of our study was to characterize the etiology of prosthetic joint infections (PJIs)&mdash, including multidrug-resistant organisms (MDRO)&mdash, by category of infection. A multicenter study of 2544 patients with PJIs was performed. We analyzed the causative microorganisms according to the Tsukayama&rsquo, s scheme (early postoperative, late chronic, and acute hematogenous infections (EPI, LCI, AHI) and &ldquo, positive intraoperative cultures&rdquo, (PIC)). Non-hematogenous PJIs were also evaluated according to time since surgery: &lt, 1 month, 2&ndash, 3 months, 4&ndash, 12 months, &gt, 12 months. AHIs were mostly caused by Staphylococcus aureus (39.2%) and streptococci (30.2%). EPIs were characterized by a preponderance of virulent microorganisms (S. aureus, Gram-negative bacilli (GNB), enterococci), MDROs (24%) and polymicrobial infections (27.4%). Conversely, coagulase-negative staphylococci (CoNS) and Cutibacterium species were predominant in LCIs (54.5% and 6.1%, respectively) and PICs (57.1% and 15.1%). The percentage of MDROs isolated in EPIs was more than three times the percentage isolated in LCIs (7.8%) and more than twice the proportion found in AHI (10.9%). There was a significant decreasing linear trend over the four time intervals post-surgery for virulent microorganisms, MDROs, and polymicrobial infections, and a rising trend for CoNS, streptococci and Cutibacterium spp. The observed differences have important implications for the empirical antimicrobial treatment of PJIs.

Este número señala algunos de los desafíos que plantea la exploración crítica de las sexualidades en la investigación en Ciencias Sociales, así como las posibilidades que abre dicha exploración. Cada uno de los artículos es un ejemplo del carácter transver- sal de la pregunta por la sexualidad y una confirmación de la riqueza de la interpretación cuando se libera de límites disciplinares. Aunque estos estudios enfatizan o se vinculan a las lógicas de la antropología, los estudios legales, la ...

Multiple factors, namely amyloid, tau, inflammation, metabolic, and perfusion changes, contribute to the cascade of neurodegeneration and functional decline occurring in Alzheimer's disease (AD). These molecular and cellular processes and related functional and morphological changes can be visualized in vivo by two imaging modalities, namely positron emission tomography (PET) and magnetic resonance imaging (MRI). These imaging biomarkers are now part of the diagnostic algorithm and of particular interest for patient stratification and targeted drug development.In this field the availability of hybrid PET/MR systems not only offers a comprehensive evaluation in a single imaging session, but also opens new possibilities for the integration of the two imaging information. Here, we cover the clinical protocols and practical details of FDG, amyloid, and tau PET/MR imaging as applied in our institutions.

A continuación presentamos un Proyecto de Innovación Educativa desarrollado en la Universidad de Málaga (España) bajo el título "Miradas multimedia sobre resiliencia y educación". La idea de este proyecto surge en el contexto de crisis económica que comienza a padecer España a partir del año 2008, y que ha afectado sobremanera a la infancia, alcanzando ésta unas cotas insostenibles de riesgo de pobreza y exclusión social. En este caldo de cultivo nace nuestra iniciativa educomunicativa, de claro acento dialéctico, dialógico y democratizador, que trata de poner en relación a docentes y alumnos de distintas áreas de conocimiento y entidades sociales, con el fin de elaborar una serie de vídeos multimedia (spot, corporativo y web) y un cortometraje documental, que permitan dar a conocer y reflexionar sobre los procesos de exclusión social y resiliencia que rodean a la infancia de nuestro país. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.

Supplemental material, dvdres-sep-2017-00131-File003 for In vivo inhibition of nuclear factor of activated T-cells leads to atherosclerotic plaque regression in IGF-II/LDLR–/–ApoB100/100 mice by Fabiana Blanco, Suvi E Heinonen, Erika Gurzeler, Lisa M Berglund, Anna-Maria Dutius Andersson, Olga Kotova, Ann-Cathrine Jönsson-Rylander, Seppo Ylä-Herttuala and Maria F Gomez in Diabetes & Vascular Disease Research

Regular Finalizado FONDECYT-REGULAR FONDECYT FONDECYT

Presentación gráfica ajustada al formato del CIIE 2017 A continuación presentamos un Proyecto de Innovación Educativa desarrollado en la Universidad de Málaga (España) bajo el título “Miradas multimedia sobre resiliencia y educación”. La idea de este proyecto surge en el contexto de crisis económica que comienza a padecer España desde el año 2008, y que ha afectado sobremanera a la infancia, alcanzado ésta unas cotas insostenibles de riesgo de pobreza y exclusión social. En este caldo de cultivo nace nuestra iniciativa educomunicativa, de claro acento dialéctico, dialógico y democratizador, que pone en relación a 10 docentes y 268 alumnos de distintas áreas de conocimiento y a 27 entidades sociales, con el fin de elaborar 76 vídeos multimedia (spot, corporativo y web) y un cortometraje documental, que permitan dar a conocer y reflexionar sobre los procesos de exclusión social y resiliencia que rodean a la infancia de nuestro país. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.

Altres ajuts: The work was supported by Comunidad de Madrid CIFRA2 B2017/BMD-3686. Fabry disease is an inherited lysosomal disease in which defects in the GLA gene lead to α-galactosidase-A deficiency, and accumulation of glycosphingolipids, including lyso-Gb3, a podocyte stressor. Therapy is available as enzyme replacement therapy and, for some patients, the chaperone migalastat. A key decision is when to start therapy, given its costs and potential impact on some aspects of quality of life. The decision is especially difficult in otherwise asymptomatic patients. A delayed start of therapy may allow kidney injury to progress subclinically up to the development of irreversible lesions. Non-invasive tools to monitor subclinical kidney injury are needed. One such tool may be assessment of podocyturia. In this issue of CKJ, [Trimarchi H, Canzonieri R, Costales-Collaguazo C et al. Early decrease in the podocalyxin to synaptopodin ratio in urinary Fabry podocytes. Clin Kidney J 2019; doi.org/10.1093/ckj/sfy053] report on podocyturia assessment in Fabry nephropathy. Specifically, they report that podocalyxin may be lost from detached urinary podocytes.

Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates. Funding: The five studies have received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 634446 to conduct the study in individuals aged 65 years or more. ECDC has contributed to fund some study sites of the EU-PC study under the Framework contract No ECDC/2014/026 for the individuals aged less than 65 years. All study teams are very grateful to all patients, general practitioners, paediatricians, hospital teams, laboratory teams, regional epidemiologists who have contributed to the studies. We acknowledge the authors, originating and submitting laboratories of the sequences from GISAID’s EpiFlu Database used for this study. All submitters of data may be contacted directly via the GISAID website www.gisaid.org Sí

In Mexico obesity has become a public health problem, several plants have been used for weight loss, including the Artichoke (Cynarascolymus), with that the Aim of this research was focused on evaluating the effect of Cynarascolymus in homeopathic doses on body mass index in obese and overweight patients at a private clinic in the metropolitan area of Guadalajara Jalisco. Material and methods. We conducted an aleatory controlled clinical trial in 34 adults aged 20 to 52 years old, overweight and with obesity (BMI> 27 kg/m2), by random sampling. They were invited to participate and they signed a written informed consent form. They took blood samples and evaluated, cholesterol, triglycerides and glucose. Cynarascolymus was administered in homeopathic doses and the body mass index (BMI) was measured for 6 appointments once every 15 days. The data was analyzed using SPSS 17. Frequencies were compared by chi square and continuous quantitative data was performed on ANOVA and T tests. Results 80% of people suffer from gastrointestinal symptoms and had a family history in obesity. BMI had no significance in the analysis of independent samples t test. Significant difference was detected between the first and third visit, ANOVA with significant F critical for weight change. Conclusions: homeopathic doses of Cynarascolymus no impact on the body mass index compared to placebo, but significant weight change.

ContextMelissa officinalis subsp. inodora Bornm. (Lamiaceae) has been used since ancient times in folk medicine against various diseases, but it has not been investigated against protozoa.Objective To evaluate the activities of M. officinalis against Leishmania braziliensis, Leishmania infantum and Trypanosoma cruzi as well as its cytotoxicity in fibroblast cell line.Materials and methods The fresh leaves were chopped into 1cm(2) pieces, washed and macerated with 99.9% of ethanol for 72h at room temperature. Antiparasitic activity of M. officinalis was accessed by direct counting of cells after serial dilution, while the cytotoxicity of M. officinalis was evaluated in fibroblast cell line (NCTC929) by measuring the reduction of resazurin. The test duration was 24h. High-performance liquid chromatography (HPLC) was used to characterise the extract.Results The extract at concentrations of 250 and 125g/mL inhibited 80.39 and 54.27% of promastigote (LC50 value=105.78g/mL) form of L. infantum, 80.59 and 68.61% of L. brasiliensis (LC50 value =110.69g/mL) and against epimastigote (LC50 value =245.23g/mL) forms of T. cruzi with an inhibition of 54.45 and 22.26%, respectively, was observed. The maximum toxicity was noted at 500g/mL with 95.41% (LC50 value=141.01g/mL). The HPLC analysis identified caffeic acid and rutin as the major compounds.Discussion The inhibition of the parasites is considered clinically relevant (

Inhibition of sclerostin, a glycoprotein secreted by osteocytes, offers a new therapeutic paradigm for treatment of osteoporosis (OP) through its critical role as Wnt/catenin signaling regulator. This study describes the epigenetic regulation of SOST expression in bone biopsies of postmenopausal women. We correlated serum sclerostin to bone mineral density (BMD), fractures, and bone remodeling parameters, and related these findings to epigenetic and genetic disease mechanisms. Serum sclerostin and bone remodeling biomarkers were measured in two postmenopausal groups: healthy (BMD T-score>-1) and established OP (BMD T-score

Specific culture media and supplements required for optimum canine cell lines growth. EMEM - Eagle’s Minimal Essential Medium, DMEM - Dulbecco’s Modified Eagle Medium, RPMI - Royal Park Memorial Institute Medium, FBS – foetal bovine serum, NEAA – non-essential amino acids. Table S2. The effect of SG2000 on the survival of LMeC xenografted mice following different SG2000 dosage regimes. Table S3. The effect of SG2000 on the survival of CMeC-1 xenografted mice following different SG2000 dosage regimes. Figure S1. In vitro cytotoxicity of SG2000 against 12 canine tumour cell lines and two canine normal cell lines. Cell viability was assessed using the SRB assay (except for cell line C2 which was assessed using the MTT assay). Results shown are the mean (± SEM) calculated from three independent experiments, expressed as a percentage absorbance at A540 nm compared to untreated control cells. A) 1 h exposure to SG2000 followed by 96 h post-incubation in drug-free medium. B) Continuous (96 h) exposure to SG2000. (PDF 404 kb)

The economics of information is a relatively new and important field of economics. This dissertation analyzes the role of information in three case studies within three different branches of economics: health economics, environmental economics, and finance and banking. First I analyze parental nutritional label usage and its effect of children's dietary outcomes (i.e. Health Eating Index and Body Mass Index). I show that parental usage of nutritional labels is associated with a better quality of their children's diet as well as an overall improvement in their health as measured by their Body Mass Index. Secondly, I study the behavioral effect of length of residency on water demand in the arid cities of Reno and Sparks in Nevada. In this case, I observe that social interaction among households affects their water usage. In particular, newcomers' watering behaviors are influenced by the prevailing social norms among neighbors that have lived in the arid area for a longer period of time. Finally, I compare the performance of local versus larger national and regional lending institutions in the years leading to the 2007 mortgage crisis. I find that local or community lenders have a significantly lower foreclosure rate during these years. Local lenders presumably base their origination decisions on an interpersonal relationship with their customers. This provides them with information that is not contained within the standard risk metrics generally used in loan applications. I discuss the policy implications of these results for each case study. Ph. D.