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Lukyanchuk O. V., Moskalenko A. M., Glass I. I., Gozhenko A. I. ENDOTHELIAL DYSFUNCTION IN CERVICAL CANCER PATIENTS. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2019;3(57):51-57. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.3465381 http://aptm.org.ua УДК 616-006:616-018 ENDOTHELIAL DYSFUNCTION IN CERVICAL CANCER PATIENTS Lukyanchuk O.V.1, Moskalenko A.M.1, Glass I.I.1, Gozhenko A.I.2 1Odessa Regional Oncology Center 2GP Scientific Research Institute of Transport Medicine, Odessa Summary The degree of endothelial damage in patients with cervical cancer during radiotherapy was studied in 11 patients aged 25 to 65 years. It has been shown that cervical cancer, like other oncological diseases, is associated with an increase in the degree of desquamation of the endothelium, which is manifested by an increase in the number of circulating endothelial cells. The severity of desquamation of the endothelium is always aggravated after radiation therapy to patients and does not depend on the type of tumor, the stage of the tumor process and the treatment option. The absence of significant violations of hemostasis in patients with cervical cancer indicates the priority role of endothelial damage in possible thrombotic complications. The change in the number of circulating endothelial cells in patients with radiation therapy for cervical cancer can be used to monitor the occurring endothelial dysfunction in order to prevent thrombotic complications. Keywords: cervical cancer, endothelium, radiation therapy, prevention of thrombotic complications

Lukyanchuk O. B., Moskalenko A. M., Glass I. I., Yatskiv V. B., Gozhenko A. I. ENDOTHELIAL DYSFUNCTION DURING RADIOTHERAPY IN ONCOLOGICAL PATIENTS. ВІСНИК МОРСЬКОЇ МЕДИЦИНИ. 2019;1(82):38-43. ISSN 0049-6804. DOI http://dx.doi.org/10.5281/zenodo.2639529 http://www.herald.com.ua УДК 616-006-085.849-06 :616-018.74 DOI http://dx.doi.org/10.5281/zenodo.2639529 ENDOTHELIAL DYSFUNCTION DURING RADIOTHERAPY IN ONCOLOGICAL PATIENTS Lukyanchuk O. B.1, Moskalenko A. M.1, Glass I. I.1, Yatskiv V. B.2, Gozhenko A. I.3 1Odessa Regional Oncology Center; 2Bukovinsky State Medical University, Chernivtsy; 3SE "Ukrainian Research Institute for Medicine of Transport of the Ministry of Health Care of Ukraine", Odessa; e-mail: prof_gozhenko@gmail.com. Summary. Lukyanchuk O. B.1, Moskalenko A. M.1, Glass I. I.1, Yatskiv V. B.2, Gozhenko A. I.3 ENDOTHELIAL DYSFUNCTION DURING RADIOTHERAPY IN ONCOLOGICAL PATIENTS. - 1Odessa Regional Oncology Center; 2Bukovinsky State Medical University, Chernivtsy; 3SE "Ukrainian Research Institute for Medicine of Transport of the Ministry of Health Care of Ukraine", Odessa; e-mail: prof_gozhenko@gmail.com. Ionizing radiation is one of the possible factors of endothelial damage. The objective: To study and evaluate the extent of endothelial damage in cancer patients during radiotherapy. We studied the content of CEC, general blood analysis data and coagulogram indices in 4 men and 8 women, average age 55.6 years. Radiotherapy was performed for all patients. Breast cancer was diagnosed in 7 patients, bladder cancer - in 1. Surgical treatment in a radical or cytoreductive volume was performed in 8 patients. Invasive ductal carcinoma was observed in 7 cases and urothelial invasive carcinoma in 1 case. In the initial state, all patients experience an increase in the level of endotheliocytes from 125 to 312 in 100 μl of blood (on average, 197.17 ± 28.31 in 100 μl of blood). After a course of radiotherapy in all patients, there was a further increase in the level of CEC, which indicates an increase in the severity of endothelial damage and an increase in endothelial desquamation. The increase in the number of CEC in the absence of significant deviations of the coagulogram indices can be considered as an early (preclinical) “marker” of the occurrence of endothelial dysfunction, which can lead to thrombotic complications. Key words: endothelium, endothelial desquamation, radiotherapy, oncological disease.

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In this work, a sample of luminous M-type giants in the Baade's Windows towards the inner Galactic Bulge is investigated in the near-infrared. The ISOGAL survey at 7 and 15 micron has given information concerning the mass-loss rates of these stars and their variability characteristics have been extracted from the MACHO database. Most are known to be semi-regular variables (SRVs). Here we discuss how their IJHK-region colours depend on period and the presence or absence of mass-loss, using results mainly taken from the DENIS and 2MASS surveys. In order to compare their colours with solar neighbourhood stars, photometric colours on the DENIS, 2MASS and ESO photometric systems have been synthesized for objects in the spectrophotometric atlas of Lancon and Wood (2000). In addition, they have been used to predict the differences in colour indicies when stars with strong molecular bands are observed using different photometric systems. The SRVs are found to inhabit the upper end of the J-K, K colour-magnitude diagram, lying just below the Miras. High mass-loss rates are associated with high luminosity. The near-infrared colours of the semi-regular variables increase in a general way with period and are reddest for the stars with significant mass-loss. The average colours of Mira variables, whose periods start at around 200 days in the Bulge, are bluer than those of the semi-regulars at this period, particularly in J-H, thanks to the association of deep water-vapour bands with large amplitude., Comment: 8 pages, 17 Postscript figures, accepted for publication in MNRAS

$^{12}CO(J=1 \to 0)$ observations of 34 blue compact and star burst galaxies are presented. Although these galaxies are experiencing vigorous star formation at the current epoch, CO has been detected in only five of them. The five detections reported in this paper are all in galaxies with relatively red colours, (B-V)_0 > 0.4. The new observations, when combined with previously published data on CO in BCGs, indicate that CO luminosity decreases with absolute luminosity of BCGs. Since the absolute luminosity of a galaxy is correlated with its metallicity, these results confirm that low metallicity BCGs have low abundances of CO gas. We also show that the star formation rate determined from the $H_{\beta}$ luminosity is lower than that determined from the far infrared luminosity., Comment: 10 pages, 2 postscript figures, A&A style, to be published by Astronomy and Astrophysics

The fragile X syndrome is the most common cause of familial mental retardation and is characterized by a fragile site at the end of the long arm of the X chromosome. The unusual genetics and cytogenetics of this X-linked condition make genetic counseling difficult. DNA studies were of limited value in genetic counseling, because the nearest polymorphic DNA loci had recombination fractions of 12% or more with the fragile X mutation, FRAXA. Five polymorphic loci have recently been described in this region of the X chromosome. The positions of these loci in relation to FRAXA were defined in a genetic linkage study of 112 affected families. The five loci--DXS369, DXS297, DXS296, IDS, and DXS304--had recombination fractions of 4% or less with FRAXA. The closest locus, DXS296, was distal to FRAXA and had a recombination fraction of 2%. The polymorphisms at these loci can be detected in DNA enzymatically digested with a limited number of restriction endonucleases. A strategy for DNA studies which is based on three restriction endonucleases and on five probes will detect one or more of these polymorphisms in 94% of women. This strategy greatly increases the utility of DNA studies in providing genetic advice to families with the fragile X syndrome.

BeppoSAX observed 8 times the gamma-ray bright blazar PKS 0528+134 in Feb. and Mar. 1997, during a multiwavelength campaign involving EGRET, onboard CGRO, and ground based telescopes. The source was in its faintest X-ray state observed so far, with an unabsorbed [2-10] keV flux of 2.5E-12 erg/cm2/s. The spectrum can be fitted with a power law, with energy index alpha_X=0.49+-0.07 between 0.1 and 10 keV. The high energy instrument PDS detected a flux in the 15-100 keV band which appears disconnected from the lower X-ray energies, most likely due to a contaminating source. We consider our findings in the context of the overall spectral energy distribution and discuss their implications for synchrotron and inverse Compton models., 9 pages, 6 figures, accepted for publication in A&A

This is an electronic version of an article published in The Astrophysical Journal. Clavel, J. et al. Steps toward determination of the size and structure of the broad-line region in active galactic nuclei. I. An 8 month campaign of monitoring NGC 5548 with IUE. The Astrophysical Journal 366 (1991): 64-81