140 results on '"Gilda Cennamo"'
Search Results
2. Editorial: Ocular ultrasonography and optical coherence tomography in the optic nerve disease
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Nicola Rosa, Gilda Cennamo, and Maddalena De Bernardo
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General Medicine - Published
- 2023
3. Intravitreal dexamethasone implant versus anti-vascular endothelial growth factor therapy combined with cataract surgery in patients with diabetic macular oedema: a systematic review with meta-analysis
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Andrea Maugeri, Gilda Cennamo, Paola Marolo, Andrew J. Lotery, Martina Barchitta, Claudio Furino, Guglielmo Parisi, Michele Reibaldi, Antonella Agodi, Antonio Longo, Giuliana Favara, Vincenza Bonfiglio, Enrico Borrelli, Matteo Fallico, Teresio Avitabile, Andrea Russo, Fallico M., Lotery A., Maugeri A., Favara G., Barchitta M., Agodi A., Russo A., Longo A., Bonfiglio V., Avitabile T., Marolo P., Borrelli E., Parisi G., Cennamo G., Furino C., Reibaldi M., Fallico, M., Lotery, A., Maugeri, A., Favara, G., Barchitta, M., Agodi, A., Russo, A., Longo, A., Bonfiglio, V., Avitabile, T., Marolo, P., Borrelli, E., Parisi, G., Cennamo, G., Furino, C., and Reibaldi, M.
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Vascular Endothelial Growth Factor A ,medicine.medical_specialty ,genetic structures ,medicine.medical_treatment ,Visual Acuity ,Endothelial Growth Factors ,Macular Edema ,Dexamethasone ,Cataract ,Ophthalmology ,Diabetes Mellitus ,Humans ,Medicine ,In patient ,Diabetic Retinopathy ,business.industry ,DEX ,cataract surgery ,Cataract surgery ,Diabetic cataract ,Bevacizumab ,Anti–vascular endothelial growth factor therapy ,Diabetic macular oedema ,anti-VEGF ,diabetic macular oedema ,Meta-analysis ,sense organs ,Implant ,business ,medicine.drug - Abstract
Objective: to compare outcomes of cataract surgery combined with either anti-Vascular Endothelial Growth Factor (anti-VEGF) therapy or dexamethasone implant (DEX) in patients with diabetic macular oedema (DMO). Methods: Pubmed and Embase databases were searched for studies reporting outcomes of diabetic cataract surgery combined with either anti-VEGF or DEX, with a follow-up ≥3 months. The primary outcome was the mean change in central macular thickness (CMT). Mean change in best corrected visual acuity (BCVA) was considered as a secondary outcome. The mean difference between baseline and post-treatment values (MD) with 95%-Confidence Interval (95%CI) was calculated and meta-analyses were performed. Results: ninteen studies were included, 8 in the DEX group and 11 in the anti-VEGF group. A significant reduction of macular thickness was shown in the DEX group at 3 months (MD = −98.35 µm; 95% CI, −147.15/−49.54), while mean CMT change was non-significant in the anti-VEGF group (MD = −21.61 µm; 95% CI, −59.46/16.24; test of group differences, P < 0.001). At 3 months, no difference in visual gain was found between the two groups (P = 0.13). Conclusions: in DMO patients, cataract surgery combined with DEX seems to provide better anatomical outcomes compared with cataract surgery combined with anti-VEGF therapy. However, our evidence was limited by significant heterogeneity. Randomised trials comparing these two different combined approaches are warranted.
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- 2021
4. OCT-A in chronic central serous chorioretinopathy treated with oral eplerenone and half-fluence photodynamic therapy: A comparative study
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Lidia Clemente, Gilda Cennamo, Daniela Montorio, Federica Fossataro, Maria Laura Passaro, and Ciro Costagliola
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Ophthalmology ,General Medicine - Abstract
Purpose To evaluate retinal and choriocapillary vessel density (VD) changes in patients with chronic central serous chorioretinopathy (CSC) treated with half-fluence verteporfin photodynamic therapy (vPDT) or eplerenone, using optical coherence tomography angiography (OCTA). Methods Patients affected by CSC and treated with vPDT and eplerenone were retrospectively studied. At baseline and 3 months after each treatment, all patients underwent a complete ophthalmological examination, including an evaluation of best-corrected visual acuity (BCVA), slit-lamp biomicroscopy, fundus examination, fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain optical coherence tomography (SD-OCT) and OCTA. Results Forty-eight eyes of patients with CSC were analysed. Twenty-four eyes were placed in the vPDT group, and 24 eyes formed the eplerenone group. In both groups, OCTA showed a significant improvement in the VD of deep capillary plexus (DCP) and choriocapillaris (CC) after treatments with respect to baseline (p 0.05). The PDT group demonstrated a statistically significant increase in the VD of DCP and CC with respect to the eplerenone group (DCP p = 0.012; CC p = 0.004). A statistically significant reduction with respect to baseline in subfoveal choroidal thickness (SFCT) (p = 0.001 for vPDT group; p = 0.001 for eplerenone group) and in central foveal thickness (CFT) (p = 0.001 for vPDT group; p = 0.001 for eplerenone group) was also found. The SFCT was significantly thinnest in the PDT group with respect to the eplerenone group (p = 0.021). Conclusion OCTA allowed us to study retinal and choriocapillary vascular changes in patients with CSC treated with vPDT and eplerenone.
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- 2022
5. Morphovascular changes after anti-VEGF intravitreal injection for a choroidal neovascularization secondary to COVID-19 infection in a pediatric patient
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Gilda Cennamo, Luigi Massa, Lucia Montanaro, Adriano Magli, and Ciro Costagliola
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Oncology ,Biophysics ,Pharmacology (medical) ,Dermatology - Published
- 2023
6. An unusual association of macular retinoschisis with progressive familiar intrahepatic cholestasis: A multimodal imaging study
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Maria Laura Passaro, Daniela Montorio, Alberto Mazzucco, Luigifilippo Magno, Michele Attaguile, Gilda Cennamo, Passaro, M. L., Magno, L., Mazzucco, A., Attaguile, M., Montorio, D., and Cennamo, G.
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medicine.medical_specialty ,Retinal Disorder ,genetic structures ,progressive familiar intrahepatic cholestasi ,TJP2 mutation ,Nerve fiber layer ,Retinoschisis ,multimodal imaging ,Fundus (eye) ,Optical coherence tomography ,Cholestasis ,Foveal ,Ophthalmology ,Medicine ,medicine.diagnostic_test ,business.industry ,inherited retinal degeneration ,General Medicine ,medicine.disease ,retinoschisi ,eye diseases ,Autofluorescence ,medicine.anatomical_structure ,sense organs ,business - Abstract
Purpose To evaluate a case of macular retinoschisis associated with a TJP2 mutation in a young woman affected by a Progressive Familiar Intrahepatic Cholestasis (PFIC) using multimodal imaging. Methods Observational case report. Results A 35-year-old woman, undergone a liver transplant for PFIC, was referred to Eye Clinic for complete ophthalmological examination and multimodal imaging. Fundus examination showed no significant alterations in both eyes while multicolor image revealed the presence of several cystes in macular region. The autofluorescence image highlighted small areas of iperautofluorescence in macular region. En-face image showed a “coral shape pattern” and structural optical coherence tomography (OCT) revealed foveal hyporeflective cystic spaces in outer and inner nuclear layers, areas of splitting within the nerve fiber layer (schisis areas) and an initial preretinal fibrosis. Lastly, OCT-angiography (OCT-A) demonstrated small perifoveal teleangectasias and slight reduction of the foveal avascular zone area. Conclusion Multimodal imaging could help to highlight the presence of a rare retinal disorder associated with a gene related systemic disease.
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- 2021
7. The role of choriocapillaris vessel density in the pathogenesis of macular neovascularization associated with choroidal osteoma
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Gilda Cennamo, Giuseppe Iacucci, Maria Angelica Breve, Daniela Montorio, Claudio Xompero, and Ciro Costagliola
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Cellular and Molecular Neuroscience ,Ophthalmology ,Sensory Systems - Abstract
To detect the vessel density of choriocapillaris (CC) vascular network in eyes affected by choroidal osteoma and in eyes complicated by macular neovascularization (MNV), using optical coherence tomography angiography (OCTA).In this retrospective study, twenty-eight eyes of 28 patients were divided into three groups: group 1 including patients with calcified choroidal osteoma, group 2 including patients with decalcified choroidal osteoma, and group 3 including patients with decalcified choroidal osteoma complicated by MNV. OCTA analyzed the vessel density of CC in these lesions localized in the peripapillary region.We enrolled 12 eyes with calcified choroidal osteoma, 11 eyes with decalcified choroidal osteoma, and 5 eyes with decalcified choroidal osteoma complicated by MNV. The eyes with decalcified choroidal osteoma and MNV revealed a statistically significant reduction in vessel density of the CC respect to the other groups (p 0.001). Moreover, the vessel density of CC in decalcified choroidal osteoma was significantly reduced compared to calcified choroidal osteoma (p 0.001).OCTA allowed a quantitative evaluation of choriocapillaris vessel density in choroidal osteoma, in order to detect the changes of this vascular network, which could lead to the development of MNV. Therefore, OCTA could be a new diagnostic tool in the clinical management of the choroidal osteoma.ClinicalTrials.gov Identifier: NCT05342324.
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- 2022
8. Structural and vascular features in cavitary congenital optic disc anomaly associated with metaphyseal acroscyphodysplasia
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Gilda Cennamo, Luca Domenico D'Andrea, and Federica Fossataro
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Male ,0301 basic medicine ,Adolescent ,genetic structures ,Optic Disk ,Telecanthus ,Physical examination ,030105 genetics & heredity ,Fundus (eye) ,Short stature ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Optical coherence tomography ,medicine ,Humans ,Knee ,Eye Abnormalities ,Fluorescein Angiography ,Coloboma ,medicine.diagnostic_test ,business.industry ,Optic Nerve ,Retinal ,General Medicine ,Anatomy ,medicine.disease ,eye diseases ,Ganglion ,Ophthalmology ,medicine.anatomical_structure ,chemistry ,030221 ophthalmology & optometry ,sense organs ,medicine.symptom ,business ,Epiphyses ,Hand Deformities, Congenital ,Exostoses, Multiple Hereditary ,Tomography, Optical Coherence - Abstract
Purpose: To evaluate the radial peripapillary vascular plexus of a cavitary congenital optic disc anomaly in a young patient with recessive autosomal metaphyseal acroscyphodysplasia using optical coherence tomography angiography (OCTA). Methods: Observational case report. Results: A 17-year-old man, with diagnosis of metaphyseal acroscyphodysplasia was referred to Eye Clinic for fundus examination and multimodal imaging for retinal epithelium hypertrophy in the right eye. Clinical examination showed cup-shaped metaphyses, short stature, hyperthelorism, and telecanthus. An optic disc coloboma was detected in the right eye on fundus examination. Wide field en-face Optical Coherence Tomography (OCT) showed a hyporeflective area corresponding to the right optic disc coloboma. At OCTA examination, the whole papillary region revealed a rarefaction of the vascular network, while the ganglion cell complex’s and retinal fiber layers’ parameters were normal in both eyes. Conclusion: The presence of coloboma disc congenital defect linked to embryological abnormalities during the development process could pave the way for a wider understanding of the pathogenesis of metaphyseal acroscyphodysplasia by increasingly framing it as a systemic disease.
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- 2021
9. Anterior segment-optical coherence tomography and diabetic retinopathy: Could it be an early biomarker?
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Luca D'Andrea, Daniela Montorio, Marina Concilio, Mariapaola Giordano, Gilda Cennamo, and Ciro Costagliola
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Diabetic Retinopathy ,Oncology ,Diabetes Mellitus, Type 2 ,Photochemotherapy ,Biophysics ,Humans ,Pharmacology (medical) ,Dermatology ,Biomarkers ,Tomography, Optical Coherence - Abstract
To measure the corneal thickness (CT), corneal epithelial thickness (CET), and corneal stromal thickness (CST) in patients affected by type 2 diabetes mellitus with good glycemic control and without any signs of diabetic retinopathy using anterior-segment optical coherence tomography (AS-OCT).60 eyes of 30 diabetic patients and 60 normal eyes of 30 healthy subjects underwent AS-OCT, evaluation of best-corrected visual acuity (BCVA), intraocular pressure (IOP), slit-lamp biomicroscopy, tear film breakup time (TBUT), Schirmer I test and fundus examination. The CT, CET, and CST maps generated corresponded to a 6-mm diameter area of the cornea that was divided into 17 sectors. We compared the CT, CET, and the CST of each sector obtained in the diabetic group with those obtained in the control group.No significant difference in terms of age, gender, BCVA, IOP, TBUT, and Schirmer I test between the two study groups was observed. The CT, CET, and CST in the central section were significantly thickened in diabetic patients than in controls (p0.001). Also, each paracentral and midperipheral sector was significantly increased in patients compared to controls (p0.05).The evaluation of the CT, CET, and CST by AS-OCT could be a valid and non-invasive biomarker in patients effected by diabetes mellitus, useful in early diagnosis of diabetic retinopathy.
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- 2022
10. Dark halo, a new biomarker in macular neovascularization: comparison between OCT angiography and ICGA-a pilot prospective study
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Federica Fossataro, Gilda Cennamo, Daniela Montorio, Lidia Clemente, and Ciro Costagliola
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Indocyanine Green ,Vascular Endothelial Growth Factor A ,Choroid ,Visual Acuity ,Reproducibility of Results ,Angiogenesis Inhibitors ,Sensory Systems ,Choroidal Neovascularization ,Cellular and Molecular Neuroscience ,Ophthalmology ,Wet Macular Degeneration ,Humans ,Prospective Studies ,Fluorescein Angiography ,Coloring Agents ,Biomarkers ,Tomography, Optical Coherence - Abstract
Purpose To compare optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) in terms of reliability in detecting dark halo in patients affected by age-related macular degeneration (AMD) complicated with type 1 macular neovascularization (MNV). Methods Eighty-nine eyes of 89 patients were analyzed at the University of Naples Federico II between January 2018 and October 2021. Each patient underwent a complete ophthalmological evaluation including fluorescein angiography, ICGA, spectral domain optical coherence tomography (SD-OCT), and OCTA. OCTA and ICGA images of dark halo were compared. The paired Student’s test and intraclass correlation coefficients were used to evaluate the differences in dark halo measurements between OCTA and ICGA images. Results Thirty-six eyes of 36 patients were included in this prospective study. Dark halo area was significantly larger in OCTA than in ICGA (1.49 ± 1.8 mm2 vs. 0.54 ± 0.5 mm2; p = 0.001). Moreover, the agreement between the two types of devices for measuring dark halo areas was poor, with a low intraclass coefficient correlation (0.397). Conclusion OCTA could be a useful and necessary tool to investigate dark halo in neovascular AMD due to its ability to visualize the areas of reduced vessel density around MNV in greater detail compared to ICGA. Clinical trial registration ClinicalTrials.gov Identifier: NCT05108285
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- 2022
11. Long-Term Outcomes in Uveal Melanoma After Ruthenium-106 Brachytherapy
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Gilda Cennamo, Daniela Montorio, Luca D’ Andrea, Antonio Farella, Elide Matano, Mario Giuliano, Raffaele Liuzzi, Maria Angelica Breve, Sabino De Placido, Giovanni Cennamo, Cennamo, G., Montorio, D., D' Andrea, L., Farella, A., Matano, E., Giuliano, M., Liuzzi, R., Breve, M. A., and De Placido, S.
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survival rate ,Cancer Research ,complications ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,complication ,eye diseases ,ruthenium-106 brachytherapy ,Oncology ,metastasis ,metastasi ,sense organs ,uveal melanoma ,local recurrence ,RC254-282 ,Original Research - Abstract
Uveal melanoma is the most common primary intraocular malignancy. The aim of this retrospective study was to report the results after ruthenium-106 (Ru-106) plaque brachytherapy for uveal melanoma in terms of tumor control, visual acuity, radiation-related complications, tumor recurrence, metastases, and patients’ survival rate during 4 years’ follow-up. A total of 355 eyes from 355 patients have been treated with Ru-106 plaque brachytherapy for uveal melanoma between February 2011 and March 2020. Five patients were lost to follow-up, and then 350 eyes of 350 patients (mean age 58 ± 11 years) were enrolled in this retrospective study. All patients underwent a complete ophthalmic examination including echography and spectral domain–optical coherence tomography. The mean follow-up was 4 years (3 months to 9 years). After treatment, the mean tumor thickness was reduced to 1.75 ± 0.21 mm. Radiation complications were found in 63% of patients: 38% showed radiation maculopathy, 11% had optic neuropathy, and 14% developed cataracts. Cancer-free survival was 99%, 97%, and 85%, respectively, at 5, 7, and 9 years. Ru-106 plaque brachytherapy represents a reliable treatment of uveal melanoma. This technique is valid and safe with a low rate of ocular complications during a long-term follow-up.
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- 2022
12. Peripapillary vascular density in resolved non-arteritic anterior ischemic optic neuropathy: colocalization between structural and vascular parameters
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Mariapaola Giordano, Gilda Cennamo, Daniela Montorio, Vincenzo Brescia Morra, Marina Concilio, Giordano, M., Montorio, D., Concilio, M., Morra, V. B., and Cennamo, G.
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Male ,medicine.medical_specialty ,genetic structures ,Peripapillary vascular density ,Fundus Oculi ,Optic Disk ,Nerve fiber layer ,Dermatology ,Fundus (eye) ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Ophthalmology ,medicine ,Humans ,Optic Neuropathy, Ischemic ,030212 general & internal medicine ,Neuroradiology ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Optical coherence tomography angiography ,eye diseases ,Ciliary arteries ,Visual field ,Arteritic anterior ischemic optic neuropathy ,Psychiatry and Mental health ,medicine.anatomical_structure ,Anterior ischemic optic neuropathy ,sense organs ,Neurology (clinical) ,business ,Microvascular Density ,Non-arteritic anterior ischemic optic neuropathy ,Tomography, Optical Coherence ,030217 neurology & neurosurgery ,Human ,Optic disc - Abstract
Introduction/aims Non-arteritic anterior ischemic optic neuropathy (NAION) is an acute infarction of the prelaminar anterior optic disc, resulting from the occlusion of posterior ciliary arteries. Here, we evaluated the correlation between structural and vascular features in a case of resolved NAION. Methods Observational case report. Results A 50-year-old male patient was referred at an Eye clinic due to an altitudinal visual field defect in the left eye, occurred 9 months before. Fundus examination was unremarkable, while structural SD-OCT reveals retinal nerve fiber layer (RNFL), ganglion cell complex (GCC) thinning associated with reduction of peripapillary vascular density at OCT Angiography. Discussion We found a precise spatial correlation among RNFL and GCC thinning, peripapillary vascular reduction and visual field defects. This case demonstrates that OCTA represents a new, valid and non-invasive imaging technique in the diagnosis and follow-up of NAION, even after the resolution of the acute phase, in the absence of clinical signs at fundus examination.
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- 2021
13. Multimodal imaging in differential diagnosis between papilledema and choroidal neovascularization associated with morning glory syndrome
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Gilda Cennamo, Daniela Montorio, Vincenzo Brescia Morra, and Ciro Costagliola
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Ophthalmology ,General Medicine - Abstract
Purpose To describe the role of optical coherence tomography angiography (OCTA) to help in differential diagnosis between papilledema and a rare case of choroidal neovascularization (CNV) associated with Morning Glory Syndrome (MGS). Methods Observational case report. Results A 22-year old man was referred to Eye clinic from Neurological unit with a diagnosis of papilledema in right eye. OCTA scans on the optic disc revealed a dense radial peripapillary vascular network while two polypoidal choroidal vasculopathy (PCV) were present in peripapillary region at the edge of staphyloma in corrispondence of choriocapillary layer. Therefore, the patient underwent three-monthly intravitreal injections of anti-vascular endothelial growth factor. One and six months after loading phase, the PCVs showed no clinical activity at structural spectral domain-OCT and OCTA. Conclusion This case revealed the crucial role of OCTA as an efficace diagnostic technique in discriminating papilledema from MGS complicated by CNV, allowing to make differential diagnosis, useful in ophthalmological and neurological clinical practice.
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- 2022
14. Study of choroidal vasculature in open angle glaucoma patients
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Gilda, Cennamo, Emanuele, Malvone, Maddalena, Marotta, Maria Angelica, Breve, and Ciro, Costagliola
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Oncology ,Biophysics ,Pharmacology (medical) ,Dermatology - Abstract
To investigate the vessel density (VD) of the choriocapillary (CC) plexus in patients affected by preperimetric glaucoma (PPG), advanced glaucoma (AG) and in a healthy control group using Optical Coherence Tomography Angiography (OCTA) in order to clarify the pathogenetic mechanisms of this disease.In this prospective observational study, 19 eyes from 19 patients affected by preperimetric glaucoma (PPG) and 18 eyes from 18 patients affected by advanced glaucoma were studied from January 2022 to May 2022 at the University of Naples "Federico II". These patients had been compared with 20 eyes of 20 healthy subjects that represented the control group. All subjects underwent EDI-OCT to assess the subfoveal choroidal thickness (SFCT). OCTA was used to evaluate the vessel density (VD) of the CC in whole image in the studies groups.The PPG and AG groups showed a statistically significant reduction in CC vessel density parameters with respect to controls (p 0.001). Regarding EDI OCT results AG patients exhibited a statistically significant increase in the SFCT compared to healthy controls (p 0.001). Whereas,no statistically significant difference was between the PPG groups and to healthy controls (p 0.851).CC vessel density could represent a helpful and sensible biomarker to identify early choroidal microvascular changes in PPG and MCI in order to better understand the vascular pathophysiological mechanisms involved in glaucoma diseases.
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- 2022
15. Retinal and Choriocapillary Vascular Changes in Early Stages of Multiple Sclerosis: A Prospective Study
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Daniela Montorio, Roberta Lanzillo, Antonio Carotenuto, Maria Petracca, Marcello Moccia, Chiara Criscuolo, Antonio Luca Spiezia, Anna Lamberti, Federico Perrotta, Giuseppe Pontillo, Gilda Cennamo, Vincenzo Brescia Morra, Montorio, D., Lanzillo, R., Carotenuto, A., Petracca, M., Moccia, M., Criscuolo, C., Spiezia, A. L., Lamberti, A., Perrotta, F., Pontillo, G., Cennamo, G., and Morra, V. B.
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vessel density ,Medicine ,OCTA ,initial demyelinating event ,multiple sclerosis ,prospective study ,Multiple sclerosi ,Initial demyelinating event ,Multiple sclerosis ,Prospective study ,Vessel density ,General Medicine ,sense organs ,Article - Abstract
Optical Coherence Tomography Angiography (OCTA) abnormalities occur in multiple sclerosis (MS) over the course of the disease. OCTA investigations at early MS stages are lacking. We aimed to investigate vessel density in macular and papillary regions over two years after an initial demyelinating event (IDE). Vessel density was analyzed in superficial, deep, choriocapillaris and radial peripapillary plexus at baseline, and after one and two years. We also evaluated structural OCT parameter changes of the ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). We evaluated 30 eyes from 15 IDE patients (7 females, 8 males, mean age 28.4 ± 9.6 years) and 30 eyes from 15 healthy controls. After 2 years, we reported in the IDE group a reduced vessel density in the superficial capillary plexus, deep capillary plexus and radial peripapillary capillary plexus with respect to the baseline (coeff. β = −2.779, p = 0.013; coeff. β = −4.055, p = 0.018 and coeff. β = −2.687, p ≤ 0.001; respectively), while GCC and RNFL thicknesses did not change. Vessel density reduction was not associated with an expanded disability status scale (EDSS) change, relapse occurrence or magnetic resonance imaging activity. The analysis of healthy controls did not reveal any impairment in OCT and OCTA parameters over 2 years of follow-up. Retinal vascular loss occurs in patients with an IDE independently from clinical and radiological disease activity. Retinal vessel density could represent a novel early biomarker to monitor the MS pathological burden.
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- 2021
16. Structural and Vascular Changes of the Choroid in Polypoidal Choroidal Vasculopathy after Intravitreal Anti-VEGF Therapy
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Gilda Cennamo, Daniela Montorio, Marina Concilio, Mariapaola Giordano, Montorio, Daniela, Giordano, Mariapaola, Concilio, Marina, and Cennamo, Gilda
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medicine.medical_specialty ,genetic structures ,Eye Diseases ,Visual Acuity ,Angiogenesis Inhibitors ,Significant negative correlation ,Ophthalmology ,Ranibizumab ,medicine ,Humans ,In patient ,Prospective Studies ,Fluorescein Angiography ,Prospective cohort study ,Retrospective Studies ,Anti vegf ,business.industry ,Choroid ,Healthy subjects ,General Medicine ,eye diseases ,Sensory Systems ,medicine.anatomical_structure ,Close relationship ,Intravitreal Injections ,sense organs ,business ,Tomography, Optical Coherence ,medicine.drug - Abstract
Introduction: This study aimed to identify the changes in vessel density (VD) of the choriocapillaris (CC) and in subfoveal choroidal thickness (SFCT) and to evaluate their correlation with functional response after 3 monthly intravitreal injections of ranibizumab (loading phase [LP]) in patients affected by polypoidal choroidal vasculopathy (PCV). Methods: A total of 30 eyes of 30 PCV patients and 30 eyes of 30 healthy subjects as the control group were enrolled in this prospective study. The best-corrected visual acuity (BCVA) was measured at baseline and after 1 month from the third intravitreal injection in each patient. The VD of CC was evaluated in the macular area by means of optical coherence tomography angiography (OCTA). Central macular thickness (CMT) and SFCT were analyzed by enhanced depth imaging (EDI)-OCT. Results: The VD of CC showed statistically lower values in PCV patients at baseline with respect to after LP and normal eyes (p < 0.001). CMT and SFCT revealed a statistically significant reduction after LP (p < 0.001). Multiple regression analysis revealed a significant negative correlation between the reduced SFCT and CMT at baseline and the improvement of BCVA after LP (p < 0.05). Conclusion: The close relationship between the thinner SFCT and better visual outcome after LP reveals the role of the EDI-OCT assessment of the choroid as a predictive biomarker of functional response to anti-VEGF therapy. This tool could provide a quantitative evaluation of structural features of the choroid avoiding mistakes of evaluation at OCTA.
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- 2021
17. Radial peripapillary vessel density as early biomarker in preperimetric glaucoma and amnestic mild cognitive impairment
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Daniela Montorio, Chiara Criscuolo, Maria Angelica Breve, Roberta Lanzillo, Elena Salvatore, Vincenzo Brescia Morra, Gilda Cennamo, Montorio, D., Criscuolo, C., Breve, M. A., Lanzillo, R., Salvatore, E., Morra, V. B., and Cennamo, G.
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Radial peripapillary capillary plexu ,Mild cognitive impairment ,Retinal Vessels ,Glaucoma ,Optical coherence tomography angiography ,Sensory Systems ,Retina ,Cellular and Molecular Neuroscience ,Ophthalmology ,Preperimetric glaucoma ,Humans ,Cognitive Dysfunction ,sense organs ,Prospective Studies ,Fluorescein Angiography ,Vessel density ,Biomarkers ,Tomography, Optical Coherence - Abstract
Purpose To investigate the vessel density (VD) of the radial peripapillary capillary (RPC) plexus in patients affected by preperimetric glaucoma (PPG), amnestic mild cognitive impairment (aMCI) and in a healthy control group using optical coherence tomography angiography (OCTA) in order to clarify the pathogenetic mechanisms of these neurodegenerative diseases. Methods In this prospective study, we studied 54 eyes of 54 patients with PPG, 54 eyes of 54 patients with aMCI and 54 healthy controls. All subjects underwent structural spectral domain optical coherence tomography (SD)-OCT to assess the ganglion cell complex (GCC) and the retinal nerve fibre layer (RNFL). OCTA was used to evaluate the VD of the RPC in different regions (whole image, inside disc and peripapillary). Results The PPG and aMCI groups showed a statistically significant reduction in SD-OCT and parameters with respect to controls (p p > 0.05). At OCTA examination, PPG and aMCI patients exhibited a statistically significant reduction in the VD of the RPC in whole image, inside and peripapillary regions compared to healthy controls (p p Conclusions RPC vessel density could represent a helpful and sensible biomarker to identify early retinal microvascular changes in PPG and MCI in order to better understand the vascular pathophysiological mechanisms involved in these neurodegenerative diseases.
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- 2021
18. Correlation between Retinal Vascularization and Disease Aggressiveness in Amyotrophic Lateral Sclerosis
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Gilda Cennamo, Daniela Montorio, Francesco Pio Ausiello, Luigifilippo Magno, Rosa Iodice, Alberto Mazzucco, Valentina Virginia Iuzzolino, Gianmaria Senerchia, Vincenzo Brescia Morra, Maria Nolano, Ciro Costagliola, Raffaele Dubbioso, Cennamo, G., Montorio, D., Ausiello, F. P., Magno, L., Iodice, R., Mazzucco, A., Iuzzolino, V. V., Senerchia, G., Brescia Morra, V., Nolano, M., Costagliola, C., and Dubbioso, R.
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disease progression ,OCT ,vascular ,inflammation ,ALS ,biomarker ,eye ,angiography ,choroid ,retinal nerve fiber layer ,Medicine (miscellaneous) ,General Biochemistry, Genetics and Molecular Biology - Abstract
Abnormalities in retinal vascularization and neural density have been found in many neurodegenerative diseases; however, conflicting results are described in Amyotrophic Lateral Sclerosis (ALS). The aim of the present study was, therefore, to systematically analyze retinal layers and vascularization by means of spectral-domain (SD-OCT) and optical coherence tomography angiography (OCT-A) in ALS patients. We enrolled 48 ALS patients and 45 healthy controls. ALS patients were divided into three groups: slow progressors (n = 10), intermediate progressors (n = 24) and fast progressors (n = 14), according to the disease progression rate. For SD-OCT, we evaluated the Subfoveal choroidal thickness (SFCT), ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). Regarding the OCT-A, we assessed the vessel density (VD) in superficial and deep capillary plexuses, radial peripapillary capillary plexus, choriocapillary and the foveal avascular zone (FAZ) area. SD-OCT exam did not show any significant differences in GCC and RNFL thickness between patients and controls and among the three ALS groups. The SFCT was statistically greater in patients compared with controls (357.95 ± 55.15 µm vs. 301.3 ± 55.80 µm, p < 0.001); interestingly, the SFCT was thicker in patients with slow and intermediate disease progression than in those with fast disease progression (394.45 ± 53.73 µm vs. 393.09 ± 42.17 µm vs. 267.71 ± 56.24 µm, p < 0.001). OCT-A did not reveal any significant results. Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-r) and disease duration did not correlate with any of the OCT parameters, except for SFCT with ALSFRS-r (r = 0.753, p = 0.024). This study demonstrated the possible association between choroidal thickness and disease activity in ALS. OCT could be a useful biomarker in the management of the disease.
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- 2022
19. Correlation between the optic nerve pial diameter and radial peripapillary vascular changes in primary open-angle glaucoma
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Michele Reibaldi, Giovanni Cennamo, Vincenzo Brescia Morra, Maria Angelica Breve, Feliciana Menna, Daniela Montorio, Gilda Cennamo, Montorio, D., Cennamo, G., Breve, M. A., Menna, F., Reibaldi, M., and Morra, V. B.
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medicine.medical_specialty ,genetic structures ,Open angle glaucoma ,Optic Disk ,Nerve fiber layer ,Glaucoma ,A-scan ultrasound ,Optic nerve pial diameter ,Optical coherence tomography angiography ,Primary open angle glaucoma ,Optic neuropathy ,Cellular and Molecular Neuroscience ,Ophthalmology ,medicine ,Humans ,Prospective Studies ,Intraocular Pressure ,business.industry ,Ultrasound ,Reproducibility of Results ,Retinal Vessels ,medicine.disease ,eye diseases ,Sensory Systems ,Visual field ,Ganglion ,medicine.anatomical_structure ,Optic nerve ,sense organs ,business ,Glaucoma, Open-Angle ,Tomography, Optical Coherence - Abstract
Purpose To assess the optic nerve pial diameter (ONPD) in patients with primary open-angle glaucoma (POAG) using standardized A-scan ultrasound and to evaluate the correlation between the ONPD and structural, vascular optic nerve head features and visual field parameters in glaucomatous eyes. Methods In this prospective study, we enrolled 126 eyes of 63 POAG patients and 124 eyes of 62 healthy controls. In all subjects, the ONPD was evaluated by means of A-scan ultrasound. Spectral domain (SD)-OCT was used to assess ganglion cell complex (GCC), retinal nerve fiber layer (RNFL), thicknesses, and the optic nerve head (ONH) morphology. OCTA measured the vessel density (VD) of radial peripapillary capillary (RPC) plexus. Results The ONPD showed a statistically significant reduction in POAG group with respect to controls (p p p = 0.009) and an increased cup-to-disc area ratio (p = 0.013) and cup volume (p p = 0.006). Moreover, significant correlation was also found between ONPD and structural SD-OCT parameters (p = 0.001) and between ONPD and visual field parameters (p = 0.001). Conclusions The standardized A-scan ultrasound measurements of the ONPD showed a significant correlation with structural and vascular glaucomatous changes measured by means of SD-OCT and OCTA. These results confirm the diagnostic reliability of the ultrasound evaluation in glaucoma optic neuropathy.
- Published
- 2021
20. Case Report: Tear liquid for diagnosis of Alzheimer disease
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Daniela Marasco, Gilda Cennamo, Salvatore Del Prete, Salvatore Troisi, Rosalaura Sabetta, Antonio Del Prete, Mario Troisi, Renato Franco, and Federica Zito Marino
- Subjects
Text mining ,business.industry ,Medicine ,Alzheimer's disease ,business ,medicine.disease ,Bioinformatics - Abstract
Introduction: The common approaches at the diagnosis of Alzheimer Disease(AD) is made with an analysis of the cerebrospinal fluid or the last techniques use the study of retinal fundus and the plaques formation, through OCT or more simply with a fundus camera. Tears’ analysis is widely discussed in literature as an essential method to describe molecular and biochemical alterations in different diseases. The aim of our study was the identification with Immunocytochemistry of Amyloid Beta-42 in tears from patients with or without familiarity for Alzheimer disease, in order to make the diagnosis earlier and more accessible compared to other invasive methods. Case presentation: Our study was performed on tears from three phenotypically healthy subjects: two of them were Caucasian with Alzheimer familiarity (48 and 55 years old) and the other one was Asian without Alzheimer familiarity ( 45 years old) and affected by an adenoviral keratoconjunctivitis at the moment of the withdrawal. Tears samples were collected from eye fornix and were examinated by immunocytochemistry (ICC) assay using anti-Amyloid Beta X-42 antibody. Two out of three tears samples showed positive Amyloid Beta-42. Conclusions: Considering that our patients were phenotypically healthy, the identification of Amyloid Beta-42 by ICC could be a candidable method to make the diagnosis of the disease earlier and more accessible and available then other current and invasive methods and it could be candidate to screening method too.
- Published
- 2021
21. The role of OCT- angiography in predicting anatomical and functional recovery after endoscopic endonasal pituitary surgery: A 1-year longitudinal study
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Gilda Cennamo, Fausto Tranfa, Luigi D'Andrea, Domenico Solari, Luigi Maria Cavallo, Maria Rosaria Scala, Daniela Montorio, Cennamo, G., Solari, D., Montorio, D., Scala, M. R., Dandrea, L., Tranfa, F., and Cavallo, L. M.
- Subjects
Male ,Longitudinal study ,Visual acuity ,genetic structures ,Cardiovascular Procedures ,Vision ,Nerve fiber layer ,Visual Acuity ,Optic chiasm ,Social Sciences ,Longitudinal Studie ,Vascular Surgery ,Diagnostic Radiology ,chemistry.chemical_compound ,Nerve Fibers ,Medicine and Health Sciences ,Psychology ,Pituitary Neoplasm ,Longitudinal Studies ,Prospective Studies ,Fluorescein Angiography ,Prospective cohort study ,Tomography ,Visual Impairments ,Multidisciplinary ,Radiology and Imaging ,Middle Aged ,Ganglion ,medicine.anatomical_structure ,Treatment Outcome ,Nerve Fiber ,Medicine ,Female ,Sensory Perception ,medicine.symptom ,Anatomy ,Tomography, Optical Coherence ,Human ,Research Article ,Adenoma ,Adult ,Natural Orifice Endoscopic Surgery ,medicine.medical_specialty ,Imaging Techniques ,Science ,Surgical and Invasive Medical Procedures ,Research and Analysis Methods ,Retina ,Pituitary adenoma ,Diagnostic Medicine ,Ophthalmology ,Endoscopic Surgery ,Preoperative Care ,medicine ,Humans ,Pituitary Neoplasms ,business.industry ,Cognitive Psychology ,Biology and Life Sciences ,Retinal ,Endoscopy ,medicine.disease ,eye diseases ,Capillaries ,Prospective Studie ,chemistry ,Cardiovascular Anatomy ,Cognitive Science ,Blood Vessels ,Perception ,sense organs ,business ,Neuroscience - Abstract
Purpose The purpose of this study was to investigate the changes in structural spectral-domain optical coherence tomography (SD-OCT), OCT Angiography (OCTA) parameters, and visual acuity, 1 year after endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing optic chiasm and compare outcomes with 48 hours postoperative data. Methods Sixteen eyes of eight patients (4 males, 4 females, mean age 52 ± 11 years) were enrolled in this prospective study. The primary outcome was to evaluate the changes over time before and after surgery, analyzing the Best Corrected Visual Acuity (BCVA), Ganglion Cell Complex (GCC), Retinal Nerve Fiber Layer (RNFL) thicknesses, the retinal vessel density (VD) of Superficial Capillary Plexus (SCP), Deep Capillary Plexus (DCP), Radial Peripapillary Capillary (RPC) and the Foveal Avascular Zone (FAZ). The secondary outcome was to identify potential biomarkers that could predict visual acuity changes after 1-year follow-up. Results When comparing SD-OCT and OCTA measurements obtained after 1 year with those observed 48 hours after surgery, GCC and RNFL were significantly improved. After a significant reduction at 48 hours, GCC thickness showed a significant increase at 1 year after surgery (p = 0.007), while a significant restoration of RNFL thickness was found at 1 year (p = 0.005), as well as the VD of SCP, DCP, and RPC values. FAZ area did not change over time. BCVA significantly improved at each time after surgery (p = 0.037, p = 0.013). A statistically significant correlation was found between the preoperative BCVA, VD of SCP, DCP, RPC, and the postoperative BCVA at 1 year (p = 0.017, p = 0.029, p = 0.031, p = 0.023). Conclusion SD-OCT and OCTA provide helpful information to identify the retinal structural and vascular improvements 1 year after surgery. OCTA parameters could serve as potential predictive markers for visual acuity recovery at long-term follow-up.
- Published
- 2021
22. Optical coherence tomography angiography in Tuberous sclerosis complicated with macular choroidal neovascularization
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Angela Turtoro, Gilda Cennamo, Michele Fortunato, Chiara Nardella, Fortunato, M., Turtoro, A., Cennamo, G., and Nardella, C.
- Subjects
medicine.medical_specialty ,genetic structures ,CNV ,Tuberous sclerosis ,Oct angiography ,Ophthalmology ,Humans ,Medicine ,Fluorescein Angiography ,Child ,Choroid ,business.industry ,OCT angiography ,General Medicine ,Optical coherence tomography angiography ,medicine.disease ,Choroidal Neovascularization ,eye diseases ,Choroidal neovascularization ,Microvascular Network ,sense organs ,medicine.symptom ,Ranibizumab ,business ,Tomography, Optical Coherence ,medicine.drug - Abstract
This study describe the optical coherence tomography angiography (OCTA) features of a young patient with Tuberous sclerosis complicated with CNV unilateral macular choroidal neovascularization during the ranibizumab therapy. OCTA scans of macular region of right eye, revealed a dense microvascular network confirming the diagnosis of CNV. After four monthly intravitreal injections, OCTA revealed a decrease of size and activity of CNV. OCTA is a valid, non-invasive, dyeless, and reliable method that could improve the diagnosis and management of CNV in child with Tuberous sclerosis.
- Published
- 2020
23. Optical coherence tomography angiography in contractile morning glory syndrome
- Author
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Giovanni Cennamo, Gilda Cennamo, Vincenzo Brescia Morra, Maria Angelica Breve, Daniela Montorio, Cennamo, Gilda., Montorio, D., Breve, M. A., Morra, V. B., and Cennamo, G.
- Subjects
Male ,Adolescent ,genetic structures ,Optic Disk ,Optic disk ,optical coherence tomography angiography ,Peripapillary retina ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Optical coherence tomography ,Vascular plexus ,Humans ,Medicine ,Eye Abnormalities ,Fluorescein Angiography ,Morning ,Morning glory syndrome ,medicine.diagnostic_test ,business.industry ,Retinal Vessels ,Syndrome ,General Medicine ,Anatomy ,Optical coherence tomography angiography ,eye diseases ,Ophthalmology ,spectral domain optical coherence tomography ,Microvascular Network ,030221 ophthalmology & optometry ,Optic nerve ,Female ,sense organs ,business ,Tomography, Optical Coherence ,030217 neurology & neurosurgery - Abstract
This study describes the optical coherence tomography and optical coherence tomography angiography features of three eyes of three patients affected by contractile morning glory syndrome. Optical coherence tomography angiography scans of the peripapillary retina revealed a dense microvascular network without any vascular difference between the superficial vascular plexus and the deep vascular plexus around the optic nerve. These optical coherence tomography angiography findings confirm that the contractile movement could be due to the presence of an autonomic cholinergic muscular mechanism in the posterior part of the globe. In fact in our cases, the contractile movement seemed to be induced by massage of the eyeball. Optical coherence tomography angiography is a valid, non-invasive, dyeless, and reliable method that could shed light on the pathogenesis of this rare disease of the optic disk.
- Published
- 2019
24. Vitreous and intraretinal macular changes in diabetic macular edema with and without tractional components
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Gilda Cennamo, Immacolata Baronissi, Davide Allegrini, Stefano Schiemer, Mariantonia Ferrara, Chiara Della Guardia, Mario R. Romano, Romano, Mario R., Allegrini, Davide, Della Guardia, Chiara, Schiemer, Stefano, Baronissi, Immacolata, Ferrara, Mariantonia, and Cennamo, Gilda
- Subjects
0301 basic medicine ,Pars plana ,medicine.medical_specialty ,genetic structures ,medicine.medical_treatment ,Diabetic macular edema ,Visual Acuity ,Vitrectomy ,Macular Edema ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Atrophy ,Refractory ,Ophthalmology ,medicine ,Humans ,Macula Lutea ,Diabetic Retinopathy ,business.industry ,Internal limiting membrane ,Diabetic retinopathy ,Non-tractional macular edema ,medicine.disease ,eye diseases ,Sensory Systems ,Vitreous Body ,030104 developmental biology ,medicine.anatomical_structure ,030221 ophthalmology & optometry ,sense organs ,Ranibizumab ,Sensory System ,business ,Tomography, Optical Coherence ,Human ,medicine.drug - Abstract
Diabetic macular edema (DME) is still one of the main causes of visual impairment. Repeated intravitreal injections of ranibizumab are considered the gold standard treatment, but the efficacy in patients with prominent cystic characteristics remains uncertain. In diabetic retinas, the identification of both antero-posterior and, particularly, tangential tractions is crucial to prevent misdiagnosis of tractional and refractory DME, and therefore to prevent poor treatment outcomes. The treatment of tractional DME with anti-VEGF injections could be poorly effective due to the influence of a tractional force. Pars plana vitrectomy (PPV) is a surgical procedure that has been widely used in the treatment of diffuse and refractory DME. Anatomical improvement, although stable and immediate, did not result in visual improvement. PPV with internal limiting membrane (ILM) peeling for the treatment of non-tractional DME in patients with prominent cysts (> 390 μm) causes subfoveal atrophy, defined as "floor effect". Epiretinal tangential forces and intraretinal change evaluation by SD-OCT of non-tractional DME are essential for determining appropriate management.
- Published
- 2018
25. Fluocinolone acetonide vitreous insert for chronic diabetic macular oedema: a systematic review with meta-analysis of real-world experience
- Author
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Teresio Avitabile, Michele Reibaldi, Andrea Russo, Matteo Fallico, Gilda Cennamo, Antonella Agodi, Andrea Maugeri, Claudio Furino, Paola Marolo, Andrew J. Lotery, Paolo Caselgrandi, Martina Barchitta, Vincenza Bonfiglio, Luca Ventre, Antonio Longo, Fallico M., Maugeri A., Lotery A., Longo A., Bonfiglio V., Russo A., Avitabile T., Furino C., Cennamo G., Barchitta M., Agodi A., Marolo P., Ventre L., Caselgrandi P., and Reibaldi M.
- Subjects
medicine.medical_specialty ,Intraocular pressure ,genetic structures ,Science ,medicine.medical_treatment ,Anti-Inflammatory Agents ,Article ,Macular Edema ,03 medical and health sciences ,0302 clinical medicine ,Diabetes complications ,Fluocinolone acetonide ,Ophthalmology ,medicine ,Glaucoma surgery ,Humans ,030212 general & internal medicine ,Glucocorticoids ,Intraocular Pressure ,Drug Implants ,Diabetic Retinopathy ,Multidisciplinary ,business.industry ,Cataract surgery ,Retinal diseases ,eye diseases ,Confidence interval ,Fluocinolone Acetonide ,Diabetic macular oedema ,Meta-analysis ,030221 ophthalmology & optometry ,Medicine ,sense organs ,Implant ,business ,medicine.drug - Abstract
We conducted a meta-analysis of real-world studies on the 0.19 mg Fluocinolone Acetonide (FAc) intravitreal implant for chronic diabetic macular oedema (DMO), comparing these findings with the Fluocinolone Acetonide for Diabetic Macular Edema (FAME) study. The primary outcome was mean change of best corrected visual acuity (BCVA) at 24 months. Secondary outcomes were 36-month mean BCVA, mean central macular thickness (CMT) change, rates of eyes receiving supplementary intravitreal therapy, cataract surgery, intraocular pressure (IOP)-lowering drops and glaucoma surgery. Mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Nine real-world studies were included. The FAc implant yielded a significantly improved BCVA at 24 and 36 months (24-month MD = 4.52; 95% CI 2.56–6.48; 36-month MD = 8.10; 95% CI 6.34–9.86). These findings were comparable with the FAME study. The FAc implant yielded significantly reduced 24- and 36-month CMT. Pooled proportions of cataract surgery, IOP-lowering drops and glaucoma surgery were 39%, 27% and 3%, respectively, all lower than the FAME study. Pooled estimate of supplementary intravitreal therapy was 39%, higher than the 15.2% of the FAME study. This meta-analysis of real-world studies confirms favorable visual and anatomical outcomes following FAc insert for chronic DMO. In real-life studies more than one third of patients received supplementary intravitreal therapy, an issue that needs to be further explored.
- Published
- 2021
26. Retinal Vascular Assessment in Psoriasis: A Multicenter Study
- Author
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Rosa Maria D’urso, Teresio Avitabile, Guglielmo Parisi, Niccolò Castellino, Francesco Lacarrubba, Andrea Russo, Giuseppe Micali, Gabriella Fabbrocini, Francesco Petrillo, Antonio Longo, Michele Reibaldi, Vincenza Bonfiglio, Maria Letizia Musumeci, Matteo Fallico, Gilda Cennamo, Anna Balato, Federica Fossataro, Pietro Alosi, Castellino N., Longo A., Fallico M., Russo A., Bonfiglio V., Cennamo G., Fossataro F., Fabbrocini G., Balato A., Parisi G., D'urso R.M., Lacarrubba F., Musumeci M.L., Alosi P., Petrillo F., Micali G., Avitabile T., Reibaldi M., Castellino, N., Longo, A., Fallico, M., Russo, A., Bonfiglio, V., Cennamo, G., Fossataro, F., Fabbrocini, G., Balato, A., Parisi, G., D'Urso, R. M., Lacarrubba, F., Musumeci, M. L., Alosi, P., Petrillo, F., Micali, G., Avitabile, T., and Reibaldi, M.
- Subjects
retina ,Intraocular pressure ,medicine.medical_specialty ,vascular changes ,genetic structures ,macula ,optical coherence tomography angiography ,psoriasis ,lcsh:RC321-571 ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,Psoriatic arthritis ,0302 clinical medicine ,Ophthalmology ,Psoriasis ,Medicine ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,psoriasi ,Original Research ,Retina ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Retinal ,Optical coherence tomography angiography ,medicine.disease ,eye diseases ,medicine.anatomical_structure ,chemistry ,Multicenter study ,Eye examination ,030221 ophthalmology & optometry ,sense organs ,business ,Neuroscience - Abstract
PurposeTo investigate the vascular status of the macula in psoriasis patients without history of ocular inflammation by Optical Coherence Tomography Angiography (OCTA).MethodsThis prospective cross-sectional multicenter study included 55 psoriasis patients and 55 control healthy subjects. A complete eye examination and 6 mm × 6 mm OCTA imaging were performed. Retinal vascular status was evaluated by analyzing vascular density (VD) of superficial vascular plexus (superficial wVD) and deep vascular plexuses (deep wVD) in a 6 mm × 6 mm area and in foveal (superficial fVD and deep fVD) and parafoveal sectors (superficial pVD and deep pVD). In addition, foveal thickness (FT) and foveal avascular zone (FAZ) and clinical variables, including best corrected visual acuity (BCVA), intraocular pressure and refractive condition, were collected.ResultsBCVA, intraocular pressure and refractive condition were comparable between cases and controls. OCTA imaging showed that superficial wVD and superficial pVD were lower in the psoriasis group in comparison with controls (p = 0.009 and p = 0.01, respectively). Similarly, deep wVD and pVD were lower in the psoriasis group in comparison with control subjects (p = 0.03 and p = 0.01, respectively). In a sub-analysis of 47 patients affected by psoriasis without psoriatic arthritis, lower values of wVD and pVD in both superficial and deep capillary plexuses were registered.ConclusionOCTA is a useful tool which provides data on vascular status of the retina in psoriasis with no ocular involvement. VD data may suggest that vascular changes may occur earlier than clinical onset of posterior inflammation.
- Published
- 2021
27. Optical Coherence Tomography Angiography Findings After Intravitreal Ranibizumab in Patients With Coats Disease
- Author
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Chiara Comune, M.E. Lionetti, Gilda Cennamo, Maria Paola Laezza, Matteo Fallico, Daniela Montorio, and Michele Reibaldi
- Subjects
SD-OCT ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Coats disease ,anti-VEGF injections ,OCTA ,retinal vascular features ,Fundus (eye) ,03 medical and health sciences ,0302 clinical medicine ,Ophthalmology ,medicine ,In patient ,Coats' disease ,Original Research ,lcsh:R5-920 ,medicine.diagnostic_test ,business.industry ,Retrospective cohort study ,General Medicine ,Optical coherence tomography angiography ,Fluorescein angiography ,medicine.disease ,eye diseases ,030221 ophthalmology & optometry ,Medicine ,sense organs ,Ranibizumab ,medicine.symptom ,lcsh:Medicine (General) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
The aim of this retrospective study was to describe the vascular features in eyes with Coats disease, using optical coherence tomography angiography (OCTA), at baseline and after 3 monthly intravitreal injections of ranibizumab. Fifteen eyes of 15 consecutive patients affected by Coats' disease were recruited in this study. All patients underwent the best-corrected visual acuity (BCVA) evaluation, fundus examination, fluorescein angiography (FA), indocyanine green angiography (ICGA), multicolor imaging, structural Spectral Domain (SD)-OCT and OCTA at baseline and 1 month after the third monthly ranibizumab injection (loading phase). Fifteen patients completed the study, of whom nine were males and six females. Mean age was 20.4 ± 2 years. BCVA was 0.46 ± 0.11 logMar and 0.47 ± 0.12 logMar at baseline and after treatment, respectively (p = 0.164). SD-OCT revealed no significant decrease in central macular thickness (486.33 μm ± 93.37 at baseline vs. 483.4 μm ± 80.97 after treatment; p = 0.915). The subretinal exudates persisted in macular region after intravitreal injections. OCTA showed a general vascular rarefaction in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillary (CC) that did not change after loading phase. This study showed no functional and vascular improvement following 3 monthly ranibizumab injections. OCTA, non-invasive technique, could be useful during follow up of these patients and provide a better understand of pathogenesis of this disorder.
- Published
- 2021
28. Optical Coherence Tomography Angiography in patients with Neurofibromatosis type 1: a quantitative vascular prospective study
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Piera Giunta, Gilda Cennamo, Pasquale Fabio Barra, Iris Scala, Daniela Montorio, and Maria Paola Laezza
- Subjects
Male ,Retinal Ganglion Cells ,medicine.medical_specialty ,Neurofibromatosis 1 ,Adolescent ,Computed Tomography Angiography ,Nerve Fibers ,Retinal Diseases ,Humans ,Medicine ,In patient ,Prospective Studies ,Neurofibromatosis ,Child ,Prospective cohort study ,business.industry ,Optic Nerve Neoplasms ,Retinal Vessels ,General Medicine ,Optical coherence tomography angiography ,medicine.disease ,Ophthalmology ,Female ,Radiology ,business ,Tomography, Optical Coherence - Published
- 2021
29. Choriocapillary vascular density changes in choroidal neovascularization associated with choroidal nevus after anti-VEGF injections
- Author
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Luca Domenico D'Andrea, Gilda Cennamo, Federica Fossataro, D'Andrea, L., Fossataro, F., and Cennamo, G.
- Subjects
Anti vegf ,retinal and choriocapillaris vascular density ,medicine.medical_specialty ,genetic structures ,business.industry ,Choroidal nevu ,OCT angiography ,General Medicine ,Optical coherence tomography angiography ,eye diseases ,Choroidal nevus ,03 medical and health sciences ,Ophthalmology ,0302 clinical medicine ,Choroidal neovascularization ,Oct angiography ,030221 ophthalmology & optometry ,medicine ,sense organs ,medicine.symptom ,business ,030217 neurology & neurosurgery - Abstract
Purpose: To evaluate choriocapillary vascular density changes in choroidal neovascularization (CNV) type 2 associated with choroidal nevus using optical coherence tomography angiography (OCT-A) before and after anti-VEGF treatment. Methods: Observational case report. Results: A 25-year-old woman, was referred to Eye Clinic and presented a decreased visual acuity in right eye. Fundus examination showed a pigmented lesion located in macular region associated with subretinal hemorrhages adjacent to the mass in right eye. The diagnosis of choroidal nevus-associated with CNV was made and confirmed by spectral domain (SD)-OCT, OCT-A, and ultrasound examination. Two monthly ranibizumab intravitreal injections (IVT) were performed and a regression of the activity of neovascular lesion was noted. OCT-A showed a reduction of choriocapillaris vessel density (VD) before the treatment and an increase of VD after IVT injections. Conclusion: OCT-A could be a non-invasive and diagnostic tool to evaluate choriocapillaris vascular changes after IVT injections in CNV associated with choroidal nevus.
- Published
- 2020
30. Expanding the Clinical and Genetic Spectrum of
- Author
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Giancarlo, Iarossi, Valerio, Marino, Paolo Enrico, Maltese, Leonardo, Colombo, Fabiana, D'Esposito, Elena, Manara, Kristjana, Dhuli, Antonio Mattia, Modarelli, Gilda, Cennamo, Adriano, Magli, Daniele, Dell'Orco, and Matteo, Bertelli
- Subjects
Adult ,Male ,Adolescent ,Visual Acuity ,Middle Aged ,Article ,molecular dynamics ,Pedigree ,Young Adult ,Phenotype ,autosomal recessive cone-rod dystrophy ,rab GTP-Binding Proteins ,compound heterozygosis ,Mutation ,Humans ,Female ,Guanosine Triphosphate ,GTPase ,Cone-Rod Dystrophies ,Aged - Abstract
The small Ras-related GTPase Rab-28 is highly expressed in photoreceptor cells, where it possibly participates in membrane trafficking. To date, six alterations in the RAB28 gene have been associated with autosomal recessive cone-rod dystrophies. Confirmed variants include splicing variants, missense and nonsense mutations. Here, we present a thorough phenotypical and genotypical characterization of five individuals belonging to four Italian families, constituting the largest cohort of RAB28 patients reported in literature to date. All probands displayed similar clinical phenotype consisting of photophobia, decreased visual acuity, central outer retinal thinning, and impaired color vision. By sequencing the four probands, we identified: a novel homozygous splicing variant; two novel nonsense variants in homozygosis; a novel missense variant in compound heterozygous state with a previously reported nonsense variant. Exhaustive molecular dynamics simulations of the missense variant p.(Thr26Asn) in both its active and inactive states revealed an allosteric structural mechanism that impairs the binding of Mg2+, thus decreasing the affinity for GTP. The impaired GTP-GDP exchange ultimately locks Rab-28 in a GDP-bound inactive state. The loss-of-function mutation p.(Thr26Asn) was present in a compound heterozygosis with the nonsense variant p.(Arg137*), which does not cause mRNA-mediated decay, but is rather likely degraded due to its incomplete folding. The frameshift p.(Thr26Valfs4*) and nonsense p.(Leu13*) and p.(Trp107*) variants, if translated, would lack several key structural components necessary for the correct functioning of the encoded protein.
- Published
- 2020
31. The Retinal Vessel Density as a New Vascular Biomarker in Multisystem Involvement in Fabry Disease: An Optical Coherence Tomography Angiography Study
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Letizia Spinelli, Roberta Esposito, Camilla Russo, Eleonora Riccio, Daniela Montorio, Gilda Cennamo, Sirio Cocozza, Teodolinda Di Risi, Ciro Santoro, Massimo Imbriaco, Giuseppe Pontillo, Antonio Pisani, Cennamo, Gilda, Montorio, Daniela, Santoro, Ciro, Cocozza, Sirio, Spinelli, Letizia, Di Risi, Teodolinda, Riccio, Eleonora, Russo, Camilla, Pontillo, Giuseppe, Esposito, Roberta, Imbriaco, Massimo, and Pisani, Antonio
- Subjects
Vascular Alterations ,medicine.medical_specialty ,Central nervous system ,left atrial volume index ,Renal function ,lcsh:Medicine ,030204 cardiovascular system & hematology ,optical coherence tomography angiography ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,peak arterial pulmonary pressure ,Internal medicine ,Medicine ,echocardiography ,retinal vessel density ,Fabry disease ,business.industry ,lcsh:R ,Retinal ,TSVDS ,General Medicine ,Optical coherence tomography angiography ,medicine.disease ,Retinal vessel ,medicine.anatomical_structure ,chemistry ,030221 ophthalmology & optometry ,Cardiology ,Biomarker (medicine) ,business - Abstract
In this study, we evaluated the possible relationship between the changes in retinal vessel density (VD) by optical coherence tomography angiography (OCTA) and the vascular alterations involving renal, cardiovascular and central nervous systems in patients affected by Fabry disease (FD). In 50 FD patients, the retinal superficial capillary plexus (SCP) and deep capillary plexus (DCP) in macular region were evaluated by OCTA examination. The patients also underwent a brain magnetic resonance imaging scan, renal and echocardiographic examinations with quantification of systolic pulmonary arterial pressure (PAPs) and left atrial volume index (LAVi). The VD of SCP and DCP was inversely related with E/e&rsquo, ratio, LAVi, interventricular septal thickness, global longitudinal strain (GLS) and PAPs (p <, 0.05). No relationship was found, with a multivariate analysis, between OCTA parameters and kidney function and neuroradiological signs of central nervous system involvement. OCTA could be a new vascular biomarker in FD, revealing a strong correlation between retinal capillary damage and myocardial impairment, possibly preceding both renal dysfunction and cerebrovascular involvement.
- Published
- 2020
32. Multimodal Imaging in Choroidal Metastasis
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Marianna Carosielli, Mario R. Romano, Gilda Cennamo, Daniela Montorio, Giovanni Cennamo, Cennamo, Gilda, Montorio, Daniela, Carosielli, Marianna, Romano, Mario R, and Cennamo, Giovanni
- Subjects
medicine.medical_specialty ,Choroidal metastasis ,genetic structures ,Drusen ,Multimodal Imaging ,Lipofuscin ,Cellular and Molecular Neuroscience ,Optical coherence tomography ,Ophthalmology ,Medicine ,Humans ,Prospective Studies ,Fluorescein Angiography ,Prospective cohort study ,Retrospective Studies ,Multimodal imaging ,Retinal pigment epithelium ,medicine.diagnostic_test ,business.industry ,Choroid ,Choroid Neoplasms ,General Medicine ,Fluorescein angiography ,medicine.disease ,eye diseases ,Sensory Systems ,medicine.anatomical_structure ,sense organs ,business ,Tomography, Optical Coherence - Abstract
Background: Choroidal metastasis represents the most common malignant intraocular tumours. Objectives: The objective of this study is to detect the structural and vascular features of choroidal metastasis by multimodal imaging. Methods: Sixteen eyes of 16 patients with choroidal metastasis were enrolled in this prospective study. The multimodal imaging was performed in all patients: fluorescein angiography, indocyanine green angiography, enhanced depth imaging optical coherence tomography (EDI-OCT), OCT angiography (OCTA), and ultrasonography. Results: The choroidal metastasis was located in the macula region in 9 eyes (57%) and in the extramacular region in 7 eyes (43%). EDI-OCT showed a mean thickness of 950 ± 246 µm, a smooth anterior tumour surface in 5 eyes (31%), and a lumpy bumpy appearance in 11 eyes (69%). The most frequent EDI-OCT features were represented by choriocapillaris thinning (100%), shaggy photoreceptors (82%), subretinal fluid with speckles (69%), subretinal lipofuscin pigment (6%), absence of drusen (100%), optical shadowing (94%), low-internal optical reflectivity (75%), and retinal pigment epithelium alterations (43%). OCTA revealed an absence of intratumoral vascular network in all cases. Conclusions: The multimodal imaging contributed to greater insights into the anatomical and vascular features of choroidal metastasis. It allows for the collection of useful information to establish an appropriate diagnosis and follow-up.
- Published
- 2020
33. The role of OCT angiography in a rare case of malignant trasformation of an optic disc melanocytoma
- Author
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Gilda Cennamo, Giovanni Cennamo, Daniela Montorio, Luca Domenico D'Andrea, Cennamo, Gilda, Montorio, Daniela, D'Andrea, Luca, and Cennamo, Giovanni
- Subjects
SD-OCT ,Adult ,medicine.medical_specialty ,Skin Neoplasms ,genetic structures ,030303 biophysics ,Optic Disk ,Biophysics ,Pigmented tumor ,Dermatology ,optic disc melanocytoma ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Oct angiography ,Rare case ,Medicine ,Humans ,Pharmacology (medical) ,Fluorescein Angiography ,0303 health sciences ,Nevus, Pigmented ,Photosensitizing Agents ,business.industry ,Optic Nerve Neoplasms ,OCT angiography ,Optical coherence tomography angiography ,eye diseases ,medicine.anatomical_structure ,Oncology ,Photochemotherapy ,Female ,sense organs ,Radiology ,Melanocytoma ,business ,Tomography, Optical Coherence ,Optic disc - Abstract
The melanocytoma is a benign, highly pigmented tumor, localized on or adjacent to the optic disc. Its malignant trasformation represents a rare event. We describe a case of a 43-years old woman returned to our observation 29 years later with a malignant melanoma from an optic disc melanocytoma evaluated by Optical Coherence Tomography Angiography (OCTA). OCTA is a valid, non-invasive, dyeless and reliable method that could improve the diagnosis of this rare case of malignant trasformation of an optic disc melanocytoma.
- Published
- 2020
34. Intravitreal dexamethasone implant one month before versus concomitant with cataract surgery in patients with diabetic macular oedema: the dexcat study
- Author
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Francesco Boscia, Salvatore Cillino, Mariacristina Parravano, Valentina Sunseri Trapani, Vincenza Bonfiglio, Michele Reibaldi, Marco Lupidi, Paola Giorno, Andrea Russo, Adriano Carnevali, Chiara M. Eandi, Gilda Cennamo, Teresio Avitabile, Matteo Fallico, Monica Varano, Claudio Furino, Francesco Bandello, Niccolò Castellino, Maurizio Battaglia Parodi, Maria Vadalà, Giacomo Panozzo, Vincenzo Scorcia, Ermete Giancipoli, Francesca Parisi, Antonio Longo, Carlo Cagini, Tito Fiore, Yannick Le Mer, Fallico, M., Avitabile, T., Castellino, N., Longo, A., Russo, A., Bonfiglio, V., Parisi, F., Furino, C., Panozzo, G., Scorcia, V., Carnevali, A., Bandello, F., Parodi, M. B., Cennamo, G., Cillino, S., Vadala, M., Sunseri Trapani, V., Cagini, C., Fiore, T., Lupidi, M., Parravano, M., Varano, M., Giorno, P., Boscia, F., Giancipoli, E., Eandi, C., Le Mer, Y., Reibaldi, M., Fallico M, Avitabile T, Castellino N, Longo A, Russo A, Bonfiglio V, Parisi F, Furino C, Panozzo C, Scorcia V, Carnevali A, Bandello F, Battaglia Parodi M, Cennamo G, Cillino S, Vadala' M, Sunseri Trapani V, Cagini C, Fiore T, Lupidi T, Parravano MC, Varano M, Giorno P, Boscia F, Giancipoli E, Eandi C, Le Mer Y, Reibaldi M., and Battaglia Parodi, M.
- Subjects
Male ,Time Factors ,Visual acuity ,genetic structures ,medicine.medical_treatment ,Visual Acuity ,Dexamethasone ,0302 clinical medicine ,dexamethasone implant ,Drug Implants ,diabetes ,cataract surgery ,General Medicine ,Treatment Outcome ,diabetic macular oedema ,Intravitreal Injections ,Female ,medicine.symptom ,Tomography, Optical Coherence ,medicine.drug ,medicine.medical_specialty ,Cataract Extraction ,Cataract ,Macular Edema ,03 medical and health sciences ,Ophthalmology ,Diabetes mellitus ,medicine ,Humans ,Adverse effect ,Glucocorticoids ,Aged ,Retrospective Studies ,Diabetic Retinopathy ,Settore MED/30 - Malattie Apparato Visivo ,business.industry ,Retrospective cohort study ,Cataract surgery ,medicine.disease ,eye diseases ,diabete ,Concomitant ,030221 ophthalmology & optometry ,Implant ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Purpose: To report clinical outcomes of two different timings of intravitreal dexamethasone (DEX) implant administration for prevention of diabetic macular oedema (DME) worsening following cataract surgery. Methods: This multicentre, retrospective study included patients with DME who received an intravitreal DEX implant 1month before cataract surgery, ‘precataract DEX’ group, or at the time of cataract surgery, ‘concomitant treatments’ group. Inclusion criteria were a follow-up ≥3months and ophthalmological examination with optical coherence tomography (OCT) imaging at baseline (cataract surgery) and throughout follow-up. Anatomical improvement was considered to be a decrease in OCT central subfield (CSF) thickness ≥20% compared to baseline. The primary outcomes were anatomical and functional results at 3months. Results: Two hundred twenty-one patients were included: 136 in the ‘precataract DEX’ group and 85 in the ‘concomitant treatments’ group. At 3months, a reduction of CSF thickness≥20% was found in 7.3% of eyes in the ‘precataract DEX group’ and in 83.7% of eyes in the ‘concomitant treatments’ group (p 
- Published
- 2020
35. Optical coherence tomography angiography in quiescent choroidal neovascularization associated with choroidal nevus: 5 years follow-up
- Author
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Raffaella Carandente, Daniela Montorio, Lidia Clemente, Fausto Tranfa, Federica Fossataro, Gilda Cennamo, Cennamo, G., Montorio, D., Fossataro, F., Clemente, L., Carandente, R., and Tranfa, F.
- Subjects
medicine.medical_specialty ,Skin Neoplasms ,genetic structures ,Visual Acuity ,03 medical and health sciences ,0302 clinical medicine ,Oct angiography ,Ophthalmology ,medicine ,EDI-OCT ,Humans ,Fluorescein Angiography ,Nevus, Pigmented ,business.industry ,Choroid ,Choroidal nevu ,OCT angiography ,General Medicine ,Optical coherence tomography angiography ,Middle Aged ,eye diseases ,Choroidal nevus ,Choroidal Neovascularization ,Choroidal neovascularization ,030221 ophthalmology & optometry ,Female ,sense organs ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Tomography, Optical Coherence ,Follow-Up Studies - Abstract
Purpose: To report a case of quiescent choroidal neovascularization (CNV) associated with choroidal nevus using optical coherence tomography angiography (OCTA) during 5 years follow-up. Methods: Observational case report. Results: A 53-year old woman was referred our department with diagnosis of choroidal nevus. At 1 year follow-up, fundus autofluorescence revealed hyper/hypoautofluorescent area, infrared image showed hyperreflective area and enhanced depth imaging OCT presented a shallow pigment epithelium detachment without exudation or hemorrhage. Fluorescein angiography and indocyanine green angiography suspected the presence of CNV. Finally, OCTA confirmed a quiescent CNV with an increased flow area of the vascular lesion without any changes in best-corrected visual acuity. At 20 months and 5 years follow-up, the CNV remained quiescent showing no clinical activity on structural SD-OCT and no changes in CNV morphology on OCTA. Conclusion: This case shows the features of quiescent CNV secondary to choroidal nevus after long-term follow-up. OCTA represents a valid imaging technique that allows to identify the CNV and to monitor its progression over time.
- Published
- 2020
36. Evaluation of corneal structures in myopic eyes more than twenty-two years after photorefractive keratectomy
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Pasquale Napolitano, Piero Donna, Nicola Rosa, Feliciana Menna, Daniela Montorio, Giovanni Cennamo, Maria Angelica Breve, Gilda Cennamo, Ugo Fiore, Montorio, D., Cennamo, G., Menna, F., Donna, P., Napolitano, P., Breve, M. A., Fiore, U., and Rosa, N.
- Subjects
medicine.medical_specialty ,Noninvasive imaging ,genetic structures ,medicine.medical_treatment ,Scheimpflug principle ,General Physics and Astronomy ,Photoablation ,Photorefractive Keratectomy ,General Biochemistry, Genetics and Molecular Biology ,Cornea ,Ophthalmology ,medicine ,Myopia ,Humans ,General Materials Science ,corneal densitometry ,scheimpflug imaging system ,business.industry ,Significant difference ,General Engineering ,General Chemistry ,Ablation ,eye diseases ,Photorefractive keratectomy ,corneal epithelial thickness ,anterior segment-optical coherence tomography ,photorefractive keratectomy ,sense organs ,business ,corneal epithelial thickne ,Tomography, Optical Coherence - Abstract
The aim of this study is to evaluate corneal epithelial thickness (CET), corneal densitometry (CD) in 84 myopic eyes (57 patients) more than 22 years after photorefractive keratectomy, using anterior segment-optical coherence tomography (AS-OCT) and Scheimpflug imaging system. The CET was significantly higher in all operated eyes than in unoperated eyes in central sector. A statistically significant increase in CD in corneal anterior layer of central sector was shown in groups of operated eyes with greater ablation depth respect to unoperated eyes. While there was no significant difference in CD between the operated eyes groups with lower ablation depth and unoperated eyes. A significant trend toward higher values in anterior CD with deeper ablations in central sector was found. These noninvasive imaging techniques allow to better understand the corneal remodeling process after photoablation and to monitor the patients over time.
- Published
- 2020
37. Optical coherence tomography angiography findings in Huntington's disease
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Laura Giovanna, Di Maio, Daniela, Montorio, Silvio, Peluso, Pasquale, Dolce, Elena, Salvatore, Giuseppe, De Michele, and Gilda, Cennamo
- Subjects
Huntington Disease ,Humans ,Retinal Vessels ,Neurodegenerative Diseases ,Prospective Studies ,Fluorescein Angiography ,Tomography, Optical Coherence - Abstract
To evaluate the retinal and choriocapillaris vascular networks in macular region and the central choroidal thickness (CCT) in patients affected by Huntington disease (HD), using optical coherence tomography angiography (OCTA) and enhanced depth imaging spectral-domain OCT (EDI SD-OCT).We assessed the vessel density (VD) in superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC) using OCTA, while CCT was measured by EDI SD-OCT.Sixteen HD patients (32 eyes) and thirteen healthy controls (26 eyes) were enrolled in this prospective study. No significant difference in retinal and choriocapillaris VD was found between HD patients and controls while CCT turned to be thinner in patients respect to controls. There were no significant relationships between OCTA findings and neurological parameters.The changes in choroidal structure provide useful information regarding the possible neurovascular involvement in the physiopathology of HD. Choroidal vascular network could be a useful parameter to evaluate the vascular impairment that occurs in this neurodegenerative disease.
- Published
- 2020
38. Peripapillary Vessel Density as Early Biomarker in Multiple Sclerosis
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Gilda Cennamo, Roberta Lanzillo, Antonietta Melenzane, Giuseppe Servillo, Marcello Moccia, Antonio Luca Spiezia, Daniela Montorio, Chiara Criscuolo, Fausto Tranfa, Anna Lamberti, Vincenzo Brescia Morra, Martina Petruzzo, Marcello De Angelis, Maria Petracca, Antonio Carotenuto, Cennamo, Gilda, Carotenuto, Antonio, Montorio, Daniela, Petracca, Maria, Moccia, Marcello, Melenzane, Antonietta, Tranfa, Fausto, Lamberti, Anna, Spiezia, Antonio L., Servillo, Giuseppe, De Angelis, Marcello, Petruzzo, Martina, Criscuolo, Chiara, Lanzillo, Roberta, and Brescia Morra, Vincenzo
- Subjects
medicine.medical_specialty ,vascular pathology ,lcsh:RC346-429 ,03 medical and health sciences ,0302 clinical medicine ,Vessel density ,Clinical history ,Ophthalmology ,biomarker ,angio-optical coherence tomograph ,clinically isolated syndrome ,vessel density (VD) ,medicine ,In patient ,Optic neuritis ,lcsh:Neurology. Diseases of the nervous system ,Original Research ,Expanded Disability Status Scale ,Clinically isolated syndrome ,business.industry ,angio-optical coherence tomography ,Multiple sclerosis ,medicine.disease ,Neurology ,030221 ophthalmology & optometry ,Biomarker (medicine) ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background: To evaluate retinal vessel density (VD) in macular and in peripapillary regions in patients with recent onset of multiple sclerosis, at initial demyelinating event (IDE) and in matched relapsing-remitting multiple sclerosis (RRMS) patients. Methods: We evaluated VD in superficial capillary plexus, deep capillary plexus, choriocapillaris and radial peripapillary capillary plexus in IDE, RRMS patients and in matched healthy controls (HCs) through Optical Coherence Tomography Angiography (OCT-A). Clinical history, including history of optic neuritis, Expanded Disability Status scale and disease duration of patients were collected. Results: Thirty patients (20 with IDE and 10 with RRMS) and 15 HCs were enrolled. IDE patients showed a lower VD in radial peripapillary capillary plexus compared with controls (coeff. β = −3.578; p = 0.002). RRMS patients displayed a lower VD in both superficial capillary plexus and radial peripapillary capillary plexus compared with HCs (coeff. β = −4.955; p = 0.002, and coeff. β = −7.446; p < 0.001, respectively). Furthermore, RRMS patients showed a decreased VD in radial peripapillary capillary plexus compared with IDE patients (coeff. β = −3.868; p = 0.003). Conclusions: Peripapillary region vessel density reduction, revealed through OCT-A, might be considered as an early event in MS, and might be relevant as a biomarker of disease pathology.
- Published
- 2020
39. Novel
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Fabiana, D'Esposito, Viviana, Randazzo, Gilda, Cennamo, Nicola, Centore, Paolo Enrico, Maltese, Rita, Malesci, Luca, D'Andrea, Matteo, Bertelli, Elio, Marciano, Giuseppe, de Crecchio, Antonino, Pioppo, Adriano, Magli, and Maria Francesca, Cordeiro
- Subjects
Adult ,Phenotype ,Genotype ,Hearing Tests ,DNA Mutational Analysis ,Mutation, Missense ,Humans ,Female ,Nerve Tissue Proteins ,Multimodal Imaging ,Usher Syndromes ,Pedigree - Abstract
Usher syndrome (USH) is an autosomal recessive disorder characterized by congenital sensorineural hearing impairment and retinitis pigmentosa. Classification distinguishes three clinical types of which type I (USH1) is the most severe, with vestibular dysfunction as an added feature. To date, 15 genes and 3 loci have been identified with theA 26-year-old female patient with profound congenital sensorineural hearing loss, nyctalopia and retinitis pigmentosa was studied. Audiometric, vestibular and ophthalmologic examination was performed. A panel of 13 genes was tested by next-generation sequencing (NGS).While the hearing loss was confirmed to be profound, the vestibular function resulted normal. Although typical retinitis pigmentosa was present, the age at onset was unusually late for USH1 syndrome. A novel homozygous missense variation (c.1187TA, p.Leu396Gln) in theGenetic and phenotypic heterogeneity are very common in both isolated and syndromic retinal dystrophies and sensorineural hearing loss. Our findings widen the spectrum of USH allelic disorders and strength the concept that variants in genes that are classically known as underlying one specific clinical USH subtype might result in unexpected phenotypes.
- Published
- 2019
40. Macular peeling-induced retinal damage: clinical and histopathological evaluation after using different dyes
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Cesare Mariotti, Mario R. Romano, Mariantonia Ferrara, Giovanni Cennamo, Gilda Cennamo, Stefania Staibano, Gennaro Ilardi, Barbara Parolini, Romano, Mario R., Ilardi, Gennaro, Ferrara, Mariantonia, Cennamo, Gilda, Parolini, Barbara, Mariotti, Cesare, Staibano, Stefania, and Cennamo, Giovanni
- Subjects
Male ,Retinal Ganglion Cells ,Time Factors ,Visual acuity ,genetic structures ,Basement Membrane ,chemistry.chemical_compound ,0302 clinical medicine ,Vitrectomy ,Prospective Studies ,Fluorescein Angiography ,Coloring Agents ,Intraoperative Complications ,Aged, 80 and over ,Glial fibrillary acidic protein ,biology ,Inner limiting membrane ,Middle Aged ,Immunohistochemistry ,Sensory Systems ,medicine.anatomical_structure ,Female ,Trypan blue ,Epiretinal membrane ,medicine.symptom ,Pars plana ,medicine.medical_specialty ,Neurofilament ,Dye ,Fundus Oculi ,Ependymoglial Cells ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Ophthalmology ,medicine ,Humans ,Neurofilament protein ,Aged ,business.industry ,Müller cell ,Pars plana vitrectomy ,Macular peeling ,medicine.disease ,eye diseases ,chemistry ,030221 ophthalmology & optometry ,biology.protein ,sense organs ,Sensory System ,business ,Indocyanine green ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Purpose: To describe functional and histopathological findings after macular peeling using different dyes. Methods: Prospective, randomized, comparative, interventional, and immunohistochemical study. Forty-five eyes from 45 patients with idiopathic epiretinal membrane (ERM) underwent pars plana chromovitrectomy with ERM and inner limiting membrane (ILM) using trypan blue 0.15% + brilliant blue 0.05% + lutein 2% in group 1 (15 eyes), trypan blue 0.15% + brilliant blue 0.025% + polyethylene glycol 3350 4% in group 2 (15 eyes), and indocyanine green 0.05% in group 3 (15 eyes). We evaluated visual acuity (VA) and macular sensitivity (MS) preoperatively, 1, 3, and 6 months after surgery. The expression of glial fibrillary acidic protein (GFAP) and neurofilament protein (NF) was assessed immunohistochemically on the ILMs peeled as markers of glial and neuronal cells. Results: In group 1, both mean VA and MS were significantly better at 1 and 3 months after surgery (P < 0.05), whereas no significant difference was found after 6 months. GFAP and NF expression was significantly lower in group 1 (P < 0.05). Conclusions: The ERM/ILM peeling is thought to rip off the intraretinal tissue, based on the amounts of GFAP and NF in the specimens. The use of lutein dyes reduces iatrogenic stress to the retinal tissue and allows a faster functional recovery in the first 3 months after surgery, suggesting a less iatrogenic adhesion to the retinal tissue
- Published
- 2018
41. Multimodal Imaging in Autosomal Dominant Cone-Rod Dystrophy Caused by Novel CRX Variant
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Paolo Enrico Maltese, Lucia Ziccardi, Paolo Esposito Veneruso, Fabiana D'Esposito, Giovanni Cennamo, Gilda Cennamo, S. Cecchin, Matteo Bertelli, Adriano Magli, Giuseppe de Crecchio, and Maria Francesca Cordeiro
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Visual acuity ,genetic structures ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,Optical coherence tomography ,Ophthalmology ,medicine ,Scotopic vision ,Multimodal imaging ,Retinal pigment epithelium ,medicine.diagnostic_test ,business.industry ,Dystrophy ,General Medicine ,Phenotype ,eye diseases ,Sensory Systems ,030104 developmental biology ,medicine.anatomical_structure ,sense organs ,medicine.symptom ,business ,Retinal Dystrophies - Abstract
Aim: To characterize by multimodal approach the phenotype of patients from a 3 generations pedigree, affected by autosomal dominant cone-rod dystrophy (CRD), found to carry a novel pathogenic variant in the cone-rod homeobox-containing (CRX) gene. Methods: Examination of the adult patients included the following tests: visual acuity, multicolour imaging, spectral domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) and OCT angiography (OCT-A) recordings. In a 2.5-year-old child, cycloplegic refraction, fundoscopy, ocular motility evaluation and electrophysiological exams were performed. Next Generation Sequencing of patients’ DNA has been carried out. Results: A novel CRX pathogenic variant has been identified in our patients. The 2.5-year-old child in the third generation was found to have inherited the variant, with no clinical signs of the condition, but electroretinographic abnormalities in the scotopic component. In the adult patients, diffuse atrophy of the retinal pigment epithelium/photoreceptor complex in the macular region was evident at the OCT and FAF, while OCT-A showed choriocapillaris density reduction. Conclusions: Multimodal study allowed the characterization of a peculiar form of CRD. The novel pathogenic variant seems to have a different effect on the phenotype if compared with a previously described similar one, giving an insight into the pathogenic mechanism of CRX-related retinal dystrophies and offering valuable information that could lead to the development of possible future therapies.
- Published
- 2018
42. Retinal and choriocapillary vascular changes in early stages of multiple sclerosis: A prospective study
- Author
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Antonio Luca Spiezia, Roberta Lanzillo, Maria Petracca, Gilda Cennamo, Anna Lamberti, Daniela Montorio, Antonio Carotenuto, Marcello Moccia, Vincenzo Brescia Morra, and Chiara Criscuolo
- Subjects
medicine.medical_specialty ,chemistry.chemical_compound ,Neurology ,chemistry ,business.industry ,Ophthalmology ,Multiple sclerosis ,Medicine ,Retinal ,Neurology (clinical) ,business ,medicine.disease ,Prospective cohort study - Published
- 2021
43. Tear Liquid for Predictive Diagnosis of Alzheimer’s Disease
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Federica Zito Marino, Renato Franco, Salvatore Troisi, Salvatore Del Prete, Gilda Cennamo, Rosalaura Sabetta, Mario Troisi, Antonio Del Prete, and Daniela Marasco
- Subjects
Medicine (General) ,Pathology ,medicine.medical_specialty ,Amyloid ,Immunocytochemistry ,R895-920 ,Alzheimer familiarity ,Disease ,Fundus (eye) ,Medical physics. Medical radiology. Nuclear medicine ,R5-920 ,diagnostic method ,medicine ,Electrical and Electronic Engineering ,business.industry ,Fornix ,medicine.disease ,eye diseases ,Atomic and Molecular Physics, and Optics ,Adenoviral keratoconjunctivitis ,Alzheimer ,Tears ,conjunctival swab ,sense organs ,Alzheimer's disease ,business ,Amyloid Beta-42 - Abstract
The common approach of the diagnosis of Alzheimer’s Disease (AD) is made with an analysis of the cerebrospinal fluid or the study of retinal fundus and the plaques formation through optical corneal tomography (OCT), or more simply with a fundus camera. Tears analysis is widely discussed in literature as an essential method to describe molecular and biochemical alterations in different diseases. The aim of our study was the identification with immunocytochemistry of Amyloid Beta-42 in tears from patients with or without familiarity for Alzheimer Disease, in order to make the diagnosis earlier and more accessible compared to other invasive methods. Our study was performed on tears from three phenotypically healthy subjects: two of them were Caucasian with Alzheimer familiarity (48 and 55 years old) and the other one was Asian without Alzheimer familiarity (45 years old) and affected by an adenoviral keratoconjunctivitis at the moment of withdrawal. Tear samples were collected from eye fornix and were examinated by immunocytochemistry (ICC) assay using anti-Amyloid Beta X-42 antibody. Two out of three tears samples showed positive Amyloid Beta-42. Considering that our patients were phenotypically healthy, the identification of Amyloid Beta-42 by ICC could be a candidable method to make the diagnosis of the disease earlier and more accessible and available then other current and invasive methods and it could be a candidate for a screening method too.
- Published
- 2021
44. Anterior Segment-Optical Coherence Tomography features in Blau syndrome
- Author
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Maria Alessio, Nicola Ciampa, Federica Fossataro, Gilda Cennamo, Francesca Orlando, Marina Concilio, Luca Domenico D'Andrea, Roberta Naddei, Fausto Tranfa, Mariapaola Giordano, Concilio, M, Cennamo, G, Giordano, M, Fossataro, F, D'Andrea, L, Ciampa, N, Naddei, R, Orlando, F, Tranfa, F, and Alessio, M.
- Subjects
Male ,medicine.medical_specialty ,Sarcoidosis ,genetic structures ,030303 biophysics ,Biophysics ,Aqueous humor ,Dermatology ,Uveitis ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Optical coherence tomography ,Anterior Eye Segment ,Ophthalmology ,Cornea ,Female patient ,Humans ,Medicine ,Pharmacology (medical) ,Anterior cornea ,Child ,Blau syndrome ,0303 health sciences ,Photosensitizing Agents ,Synovitis ,medicine.diagnostic_test ,business.industry ,Arthritis ,Panuveitis ,medicine.disease ,Anterior Segment-Optical Coherence Tomography ,eye diseases ,medicine.anatomical_structure ,Photochemotherapy ,Oncology ,Child, Preschool ,Chronic anterior uveitis ,Female ,sense organs ,business ,Tomography, Optical Coherence - Abstract
Blau syndrome (BS) is a rare granulomatous auto-inflammatory disease, characterized by the classic clinical triad of joints, skin and ocular involvements. Ocular manifestation usually consists in a bilateral insidious chronic anterior uveitis with a potential evolution to panuveitis. We describe the case of two siblings, an 8-years old female and a 5-years old male, with a diagnosis of BS, evaluated by Anterior Segment-Optical Coherence Tomography (AS-OCT). In the female patient, slit-lamp examination revealed bilateral anterior granulomatous uveitis and inflammatory sequelae. AS-OCT revealed high intensity reflective layers in the anterior cornea, hyperreflective dots both in the aqueous humor and in the posterior corneal surface. In the male, no signs of inflammation were detected both on slit-lamp examination and AS-OCT scans. AS-OCT is a valuable, non-invasive tool that could improve the diagnosis of ocular involvement, better characterize and follow-up corneal alterations and anterior segment features in pediatric patients with BS.
- Published
- 2021
45. Retinal and Optic Disc Vascular Changes in Patients Using Long-Term Tadalafil: A Prospective Non-Randomized Matched-Pair Study
- Author
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Achille Aveta, Giuseppe Celentano, Chiara Comune, Gilda Cennamo, Marco Capece, Daniela Montorio, Ciro Imbimbo, Gianluigi Califano, Alberto Melchionna, Felice Crocetto, Capece, Marco, Montorio, Daniela, Comune, Chiara, Aveta, Achille, Melchionna, Alberto, Celentano, Giuseppe, Imbimbo, Ciro, Crocetto, Felice, Califano, Gianluigi, and Cennamo, Gilda
- Subjects
Medicine (General) ,medicine.medical_specialty ,erectile dysfunction ,Clinical Biochemistry ,Nerve fiber layer ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,R5-920 ,0302 clinical medicine ,Vascularity ,Ophthalmology ,Medicine ,In patient ,business.industry ,Retinal ,medicine.disease ,eye ,radical prostatectomy ,eye diseases ,Tadalafil ,Ganglion ,Erectile dysfunction ,medicine.anatomical_structure ,chemistry ,retinal vascularity ,030221 ophthalmology & optometry ,sense organs ,medicine.symptom ,business ,tadalafil ,030217 neurology & neurosurgery ,Optic disc ,medicine.drug - Abstract
Retinal, choroidal and optic disc vascularity has never been evaluated in patients taking PDE5is long-term. The aim of our study was to evaluate the neurostructural and vascular changes after long-term use of tadalafil, using spectral domain (SD)-optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). In the present clinical trial, 27 patients who have been taking tadalafil 20 mg on alternate days (OAD) for at least 6 months (Group A) were enrolled. The matched group consisted of 27 healthy men (Group B). Both groups of patients underwent SD-OCT to study ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) and choroidal thickness and OCTA for the evaluation of superficial capillary plexus (SCP), deep capillary plexus (DCP), choriocapillaris (CC) and radial peripapillary capillary (RPC). A reduction in SCP, DCP and RPC vessel density was found in patients using tadalafil long-term. Retinal and optic disc toxicity may be detected using modifications of capillary vessel density. Further studies are needed to investigate the possibility of a causal association.
- Published
- 2021
46. Association of neovascular age-related macular degeneration with month and season of birth in Italy
- Author
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Gilda Cennamo, Salvatore Cillino, Andrea Russo, Michele Reibaldi, Luca Pani, Vincenza Bonfiglio, Maurizio G. Uva, Alessandra Casuccio, Claudio Furino, Mariacristina Parravano, Entela Xoxi, Antonio Longo, Teresio Avitabile, Guglielmo Parisi, Longo, A., Casuccio, A., Pani, L., Avitabile, T., Cillino, S., Uva, M., Bonfiglio, V., Russo, A., Parisi, G., Cennamo, G., Furino, C., Parravano, M., Xoxi, E., Reibaldi, M., Longo, Antonio, Casuccio, Alessandra, Pani, Luca, Avitabile, Teresio, Cillino, Salvatore, Uva, Maurizio G, Bonfiglio, Vincenza, Russo, Andrea, Parisi, Guglielmo, Cennamo, Gilda, Furino, Claudio, Parravano, Mariacristina, Xoxi, Entela, and Reibaldi, Michele
- Subjects
Male ,Vascular Endothelial Growth Factor A ,Aging ,genetic structures ,Month of birth ,VEGF receptors ,neovascular AMD ,Angiogenesis Inhibitors ,Aptamers ,Macular Degeneration ,0302 clinical medicine ,Season of birth ,Receptors ,80 and over ,Medicine ,Registries ,Aged, 80 and over ,Neovascularization, Pathologic ,biology ,Vascular Endothelial Growth Factor ,Incidence ,Incidence (epidemiology) ,Aptamers, Nucleotide ,Bevacizumab ,Treatment Outcome ,Italy ,anti-VEGF ,Female ,Seasons ,Nucleotide ,Neovascular age-related macular degeneration ,Research Paper ,medicine.drug ,Anti-VEGF ,Neovascular AMD ,Aged ,Humans ,Ranibizumab ,Receptors, Vascular Endothelial Growth Factor ,Recombinant Fusion Proteins ,Cell Biology ,neovascular age-related macular degeneration ,03 medical and health sciences ,Age related ,Neovascularization ,Pathologic ,season of birth ,business.industry ,month of birth ,Macular degeneration ,medicine.disease ,eye diseases ,030221 ophthalmology & optometry ,biology.protein ,sense organs ,business ,030217 neurology & neurosurgery ,Demography - Abstract
In order to investigate the influence of season and month of birth on the risk of neovascular age-related macular degeneration (n-AMD) in Italy, we evaluated the month birth and sex of all patients, recorded in the anti-vascular endothelial growth factor (VEGF) monitoring registry of the Italian Medicines Agency, born between 1925-1944, who received intravitreal anti-VEGF injections for n-AMD between January 1, 2013 and July 29, 2015. The numbers of all births in Italy in the same years, extracted from the Italian National Institute of Statistics, were used to calculate the expected number of n-AMD cases. Overall, 45,845 patients (19,207 men, 26,638 women) received intravitreal anti-VEGF for n-AMD; in the same years, 20,140,426 people (10,334,262 male, 9,806,164 female) were born in Italy. Comparing the observed number of n-AMD cases with the expected number of n-AMD cases in each season, we found that the season-specific risk for n-AMD was 2.5% higher for those born in summer (OR= 1.03, Bonferroni-corrected P= 0.008) and 3% lower for those born in winter (OR= 0.96, Bonferroni-corrected P= 0.0004). When considering the month of birth, the risk of n-AMD was 5.9% lower for people born in January (OR= 0.93, Bonferroni-corrected P= 0.0012). The factors causing such differences should be determined.
- Published
- 2016
47. Multimodal Imaging of Optic Nerve Head Capillary Hemangioma
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Gilda Cennamo, Chiara Comune, Giuseppe de Crecchio, Giovanni Cennamo, Cennamo, Gilda, Comune, Chiara, Cennamo, Giovanni, and de Crecchio, Giuseppe
- Subjects
Male ,medicine.medical_specialty ,Fundus Oculi ,Optic Disk ,Multimodal Imaging ,Hemangioma ,medicine ,Humans ,Hemangioma, Capillary ,Fluorescein Angiography ,Multimodal imaging ,business.industry ,Optic Nerve Neoplasms ,Capillary hemangioma ,Optic Nerve Neoplasm ,General Medicine ,Middle Aged ,medicine.disease ,Ophthalmology ,Optic nerve ,Head (vessel) ,Radiology ,Tomography ,business ,Tomography, Optical Coherence ,Human - Published
- 2018
48. Optical coherence tomography angiography to assess vascular remodeling of the choriocapillaris after low-fluence photodynamic therapy for chronic central serous chorioretinopathy
- Author
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Pia Clara Pafundi, Giuseppe Caputo, Gilda Cennamo, Michela Cennamo, Giuseppe de Crecchio, Giovanni Cennamo, Federica Mirra, Cennamo, Gilda., Cennamo, M., Caputo, G., Mirra, F., Pafundi, P. C., de Crecchio, G., and Cennamo, Giovanni.
- Subjects
Adult ,Male ,medicine.medical_specialty ,genetic structures ,Chorioretinopathy ,medicine.medical_treatment ,Biophysics ,Visual Acuity ,Photodynamic therapy ,Foveal thickness ,Dermatology ,Vascular Remodeling ,Chronic central serous chorioretinopathy ,Ophthalmology ,medicine ,Humans ,Pharmacology (medical) ,CSCR ,Fluorescein Angiography ,Aged ,Photosensitizing Agents ,Low fluence ,medicine.diagnostic_test ,business.industry ,Choroid ,Verteporfin ,Optical coherence tomography angiography ,Middle Aged ,Fluorescein angiography ,eye diseases ,Oncology ,Central Serous Chorioretinopathy ,Photochemotherapy ,Female ,sense organs ,business ,OCTA ,After treatment ,Tomography, Optical Coherence ,medicine.drug - Abstract
Background To evaluate the efficacy of optical coherence tomography angiography (OCTA) in identifying changes in the choriocapillaris layer after low-fluence verteporfin photodynamic therapy (vPDT) in patients affected by chronic central serous chorioretinopathy (CSCR). Methods Low-fluence vPDT was performed on 28 eyes of 27 patients with CSCR. All patients underwent the following tests at baseline and 6 months after treatment: best corrected visual acuity (BCVA), fluorescein angiography, indocyanine green angiography, enhanced depth imaging OCT and OCTA. Results Subretinal fluid was completely absorbed in 18 of the 28 affected eyes (64.3%) after low-fluence vPDT (“responders”), and incompletely absorbed in 10 eyes (35.7%) (“non responders”). BCVA was significantly improved (p = 0.006) whereas central foveal thickness and choroidal foveal thickness were significantly decreased (p = 0.001 and p = 0.00 respectively) 6 months after treatment in responders. Conclusions OCTA revealed a different pattern of vascular remodeling of the choriocapillaris between CSC patients who responded and those who did not respond to low-fluence vPDT.
- Published
- 2019
49. A Preliminary Investigation on Human Tears by Means of Surface Enhanced Raman Spectroscopy
- Author
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Maria Lepore, Gilda Cennamo, Mikhail Lisitskiy, Daniela Montorio, Carlo Camerlingo, Salvatore Del Prete, and Marianna Portaccio
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Aqueous solution ,Materials science ,Analytical chemistry ,Surface-enhanced Raman spectroscopy ,Laser ,eye diseases ,law.invention ,Rhodamine 6G ,chemistry.chemical_compound ,chemistry ,law ,Colloidal gold ,Tears ,Organic component ,Volume concentration - Abstract
Tears are exceptionally reach sources of information on the health status of the eyes, as well as of the whole body functionality, due to the presence of a large variety of salts and organic components that can be altered by pathologies, eye's diseases and/or inflammatory processes. Surface enhanced Raman spectroscopy (SERS) provides an unique methods for analyzing low concentration organic fluids as tears. In this work, home made SERS substrates were prepared by using gold nanoparticles for investigating fluid samples excited by a HeNe laser (λ= 633 nm). The method was preliminary tested on Rhodamine 6G aqueous solutions at different concentrations, proving the possibility to sense substance concentration as low as the levels of the main organic components of the human tear. Tears were extracted from informed healthy patients by means of a not-invasive methods based on a direct collection of the tear fluid by means of a suitable micro-capillary tube. A clear SERS response was obtained for human tear samples. The SERS spectra were analyzed by using a “wavelet” based algorithm and a deconvolution procedure in terms of Lorentzian curves, in order to identify the contributions of biochemical components. The SERS spectra analysis allowed a preliminary insight on tear composition.
- Published
- 2018
50. The role of optical coherence tomography angiography in reticular pseudodrusen
- Author
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Gilda Cennamo, Nicola Mirto, Daniela Montorio, Luca Domenico D'Andrea, Montorio, D., D'Andrea, L., Mirto, N., and Cennamo, G.
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Male ,medicine.medical_specialty ,Reticular pseudodrusen ,genetic structures ,030303 biophysics ,Biophysics ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Vessel density ,Ophthalmology ,Humans ,Medicine ,Pharmacology (medical) ,Prospective Studies ,Fluorescein Angiography ,Prospective cohort study ,Aged ,0303 health sciences ,Photosensitizing Agents ,business.industry ,Healthy subjects ,Retinal ,Blood flow ,Optical coherence tomography angiography ,Macular degeneration ,medicine.disease ,eye diseases ,Photochemotherapy ,Oncology ,chemistry ,Early age-related macular degeneration ,Female ,sense organs ,OCTA ,business ,Tomography, Optical Coherence - Abstract
Background: To investigate the changes in retinal and choriocapillaris vessel density (VD) in patients effected by early age-related macular degeneration (AMD) and reticular pseudodrusen (RPD), using Optical Coherence Tomography Angiography (OCTA). Methods: A total of seventy-eight eyes of 78 patients (43 male, 35 female, mean age 72.61 ± 5.15) with non-neovascular AMD (38 eyes with early AMD and 40 eyes with RPD) was recruited in this observational prospective study. Forty eyes of 40 healthy subjects represented the control group. The VD was measured in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris in different macular regions. Results: There were no significant differences in VD of the SCP and DCP among the controls and the two study groups (p > 0.05). The VD of the choriocapillaris revealed a statistically significant reduction in early AMD and RPD groups respect to controls (p < 0.001). Furthermore, the patients with RPD showed a significantly decreased VD respect to patients with early AMD in different macular regions (p < 0.001). Conclusions: The quantitative analysis of retinal and choriocapillaris blood flow by OCTA provided useful information regarding the vascular changes in non-neovascular AMD patients suggesting that the choriocapillaris loss is mainly involved in the pathogenesis of RPD.
- Published
- 2021
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