1. Safety and Efficacy of
- Author
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Muendo Charity, Mutile, Mutiso Joshua, Muli, and Gicheru Michael, Muita
- Subjects
Balb/c mice ,Prosopis juliflora ,Sodium stibogluconate ,Original Article ,Leishmania donovani - Abstract
Background: Visceral Leishmaniasis caused by Leishmania donovani is a major health problem in the tropics and sub-tropic regions where it is endemic. We aimed in testing the leishmanicidal activity and toxicity of Prosopis juliflora leaf extract in BALB/c mice and in vitro test systems respectively. Methods: In the year 2017 until 2019, BALB/c mice of mixed sexes aged between 6 and 8 weeks in groups of 8 were used. Group I treated with 100 mg/kg of P. juliflora extract, Group II -1 mg/kg of Sodium stibogluconate (SSG) and Group III treated with normal saline. All mice were anaesthized and sacrificed to obtain blood, spleen samples for antibody measurements, and determination of parasite loads. Results: There was significant inhibitory effect (P
- Published
- 2021