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65 results on '"Giammona, Gaetano"'

1. Printable Thermo- and Photo-stable Poly(D,L-lactide)/Carbon Nanodots Nanocomposites via Heterophase Melt-Extrusion Transesterification

Author

Mauro, Nicolò, Andrea Utzeri, Mara, Sciortino, Alice, Cannas, Marco, Messina, Fabrizio, Cavallaro, Gennara, Giammona, Gaetano, Mauro, Nicolò, Andrea Utzeri, Mara, Sciortino, Alice, Cannas, Marco, Messina, Fabrizio, Cavallaro, Gennara, and Giammona, Gaetano

Subjects
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo, General Chemical Engineering, Settore FIS/01 - Fisica Sperimentale, Environmental Chemistry, carbon dots, polymer, nanocomposites, General Chemistry, Industrial and Manufacturing Engineering
Abstract

We propose for the first time an one-pot synthesis of carbon nanodots-poly(D,L-lactide) (CDs-PLA) nanocomposites, obtained by a simple reactive melt-extrusion process involving polar surface groups of multicolor CDs and ester bonds of PLA chains. Apart from providing an excellent method to produce polyester-coated CDs, our protocol allows obtaining perfect PLA@CDs blends giving rise to homogeneous extruded PLA@CDs filaments (ePLA@CDs) suitable for 3D printing applications (e.g., additive manufacturing for biomaterials and biodegradable encoded polymer ink technology). We demonstrate that ePLA@CDs filaments can be used to build a huge range of fluorescent objects with increasing architectural complexity (from grids to orthopedic screws). The designed nanocomposite synergistically combines the brilliant optical properties of hydrophilic N,S-CDs with the known biodegradable and biocompatible properties of PLA. Indeed, CDs endow PLA with peculiar thermo- and photo-stable multicolor emission (from blue to NIR) as well as good printability, avoiding typical self-quenching phenomena of CDs in solid-state. Besides, the use of CDs as probe-filler assumes a multifunctional role improving water uptake, degradation rate and also increasing material-cell interactions in comparison with the plain PLA. Overall, our results pave the way for the design of fluorescent implants providing real-time localization and monitoring of degradation state via non-invasive fluorescence imaging.

Published
2022
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2. Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying

Author

Bahijja Tolulope Raimi-Abraham, Laura Modica de Mohac, Roberto Caruana, Giammona Gaetano, Mariano Licciardi, De Mohac, Laura Modica, Raimi-Abraham, Bahijja, Caruana, Roberto, Gaetano, Giammona, and Licciardi, Mariano

Subjects
chemistry.chemical_classification, Materials science, Pharmaceutical Science, Excipient, 02 engineering and technology, Polymer, 021001 nanoscience & nanotechnology, 030226 pharmacology & pharmacy, Dosage form, 03 medical and health sciences, 0302 clinical medicine, Chemical engineering, chemistry, Spray drying, medicine, Dissolution testing, Solubility, 0210 nano-technology, Dispersion (chemistry), Multicomponent solid dispersion, Spray-drying, Dissolution rates, Dosage form, Polymers, medicine.drug
Abstract

The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In this review, we aimed to improve the definition of multicomponent solid dispersions as a new generation of solid dispersions capable to improve both formulation issues and the therapeutic effect of the final dosage form. As it is well-known the use of solid dispersions to improve drug dissolution rate and solubility, this review describes the field of solid dispersions as well as the formulation strategies available for their production. In particular, the review highlights the use of the spray-drying technique and the benefits provided by this method in the manufacturing of multicomponent solid dispersion.

Published
2020
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5. SIMPLE, BIOCOMPATIBLE AND COST-EFFECTIVE INULIN BASED SIRNA DELIVERY SYSTEMS

Author

SARDO, Carla, LICCIARDI, Mariano, SCIALABBA, Cinzia, GIAMMONA, Gaetano, CAVALLARO, Gennara, Farra, R, Dapas, B, Grassi, M, Grassi, G., Sardo, C, Licciardi, M, Scialabba, C, Giammona, G, Cavallaro, G, Farra, R, Dapas, B, Grassi, M, and Grassi, G

Subjects
INULIN, SIRNA DELIVERY, SIRNA DELIVERY, INULIN
Published
2014

7. MODIFICATION OF HYDROPHOBIC SURFACE WITH POLYASPARTAMIDE-BASED POLYCATIONS FOR BIOMEDICAL APPLICATION

Author

SARDO, Carla, LICCIARDI, Mariano, GIAMMONA, Gaetano, CAVALLARO, Gennara, Coudane, J, Nottelet, B, Sardo, C, Licciardi, M, Giammona, G, Coudane, J, Nottelet, B, and Cavallaro, G

Subjects
thiol-yne click reaction, PHEA, lipoic acid, antibacterial PLA surfaces, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo, PHEA, lipoic acid, antibacterial PLA surfaces, thiol-yne click reaction
Abstract

A convenient way for the achievement of polymer-based solid materials for specific biomedical applications is grafting the appropriate macromolecules onto the surfaces in order to confer them specific properties. To date many approaches have been used to covalently modify polymeric surfaces, and among them chemoselective coupling reactions, usually referred as “click” reactions, gained much attention thanks to simple procedure with high reaction rate under mild reaction conditions (at normal temperature and pressure) [1]. In particular, radical-initiated thiol-yne “photo-click” chemistry has been demonstrated as an effective way to functionalize efficiently surfaces. This method gives also the possibility to avoid the presence of residual metal impurities and to increase the density of surface functionalization, thanks to the possibility to yield bis-addition products on triple bonds [2]. In this frame, copper catalysed “click” chemistry was recently used to confer antibacterial and antibiofilm properties to propargylated PLA surfaces by immobilization of polyquaternary ammoniums.[3] Here, this approach was enlarged to thiol-yne “photo-click” chemistry that was used to link a polyaspartamide copolymer, bearing positive permanent charges to PLA surfaces. Therefore a copolymer of α,β-poly(N-2-hydroxyethyl)-DL-aspartamide bearing in the side chains ethylendiammine (EDA), carboxypropyl trimethylammonium (CPTA) groups and lipoic portions was synthesized (PHEA-EDA-CPTA-LA). In parallel, a hydrophobic “clickable” propargilated PLA94 surface was prepared according to a previously described procedure.[3] After proper reduction of the disulfide bridge, PHEA-EDA-CPTA-LA was conjugated to the propargilated PLA94 surface by photo-chemical reaction between free thiols and propargilic groups. To confirm the covalent surface modification and quantify the density of surface functionalization, SEC and XPS analysis were performed. Further, it was investigated on the biocompatibility of PHEA-EDA-CPTA-LA modified PLA94 surfaces monitoring in vitro the proliferation of mouse fibroblasts.

Published
2013

18. Cationic solid-lipid nanoparticles as vector for RNA delivery

Author

MONTANA G, BONDÌ ML, SAN BIAGIO PL, DI CARLO M., CARROTTA, Rita, PICONE, Pasquale, CRAPARO, Emanuela Fabiola, GIAMMONA, Gaetano, MONTANA G, BONDÌ ML, CARROTTA R, PICONE P, CRAPARO EF, SAN BIAGIO PL, GIAMMONA G, and DI CARLO M

Published
2006

34. Folate-mediated targeting of polymeric conjugates of gemcitabine

Author

Gennara, Cavallaro, Mariano, Licciardi, Licciardi, Mariano, Stefano, Salmaso, Paolo, Caliceti, Giammona, Gaetano, CAVALLARO G, LICCIARDI M, SALMASO S, CALICETI P, and GIAMMONA G

Subjects
Antimetabolites, Antineoplastic, Time Factors, Stereochemistry, Cell Survival, polyaspartamide, Chemical structure, Pharmaceutical Science, Receptors, Cell Surface, Conjugated system, Deoxycytidine, Drug Delivery Systems, Folic Acid, Cell Line, Tumor, folate-mediated targeting, Extracellular, Humans, Prodrugs, Incubation, Polyhydroxyethyl Methacrylate, Drug Carriers, Dose-Response Relationship, Drug, Chemistry, polymeric conjugate, Folate Receptors, GPI-Anchored, Succinates, Hydrogen-Ion Concentration, Gemcitabine, In vitro, Biochemistry, Cell culture, Carrier Proteins, Macromolecule, Conjugate
Abstract

The synthesis of two new macromolecular prodrugs for active tumor targeting was set up. Gemcitabine (2'-deoxy-2',2'-difluorocytidine) was conjugated to alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) through succinyl or diglycolyl hydrolysable spacers. The targeting agent folic acid was attached to the macromolecular backbone through the aminocaproic spacer. The two conjugates [PHEA-(5'-succinylgemcitabine)-1'-carboxypentyl-folamide and PHEA-(5'-diglycolyl-gemcitabine)-1'-carboxypentyl-folamide], were purified and extensively characterised by spectroscopic (UV, IR and NMR) and chromatographic analyses to determine the correct chemical structure, the purity degree and the reaction yield. In vitro studies demonstrated that the drug release depends on the spacer arm (diglycolyil or succinyl) and incubation pH. After 30 h incubation at pH 7.4, mimicking the plasma and extracellular compartments, the gemcitabine release from the succinyl and diglycolyl derivatives was 28 and 31%, respectively. After 30 h incubation at pH 5.5, mimicking the lisosomial compartment, the drug released from both bioconjugates was lower than 13%. In plasma, the polymer conjugation increased the drug stability and provided for a sustained drug release. In vitro citotoxicity studies performed using human nasopharyngeal epidermal carcinoma KB cells demonstrated that PHEA-(5'-succinylgemcitabine)-1'-carboxypentyl-folamide displays an higher dose dependent cytotoxic effect with respect to PHEA-(5'-diglycolyl-gemcitabine)-1'-carboxypentyl-folamide.

Published
2005

50. A multifunctional peptidomimetic macromolecule to fight polymicrobial infections

Author

Domenico Schillaci, Nicolò Mauro, Paola Varvarà, Cusimano, M., Daniela Maria Geraci, Mario Giuffre, Cavallaro, Gennara, Carmelo Maida, and Giammona, Gaetano

Subjects
Settore MED/38 - Pediatria Generale E Specialistica, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo, Settore BIO/19 - Microbiologia Generale, Settore MED/42 - Igiene Generale E Applicata, antimicrobial polymers, synthetic polypeptides, colistin, vancomycin, Pseudomonas aeruginosa, Staphylococcus aureus, biofilms

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