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1. brainlife.io: A decentralized and open source cloud platform to support neuroscience research

Author

Hayashi, Soichi, Caron, Bradley, Heinsfeld, Anibal S., Vinci-Booher, Sophia, McPherson, Brent C., Bullock, Daniel N., Berto, Giulia, Niso, J. Guiomar, Hanekamp, Sandra, Levitas, Daniel, Kitchell, Lindsey, Leong, Josiah, Silva, Filipi N., Koudoro, Serge, Willis, Hanna, Jolly, Jasleen, Pisner, Derek, Zuidema, Taylor, Kurzwaski, Jan, Mikellidou, Koulla, Bussalb, Aurore, Rorden, Christopher, Victory, Conner, Bhatia, Dheeraj, Aydogan, D. Baran, Yeh, Frank C., Delogu, Franco, Guaje, Javier, Veraart, Jelle, Fischer, Jeremy, Faskowitz, Joshua, Chaumon, Maximilien, Fabrega, Ricardo, Hunt, David, McKee, Shawn, Brown, Shaw T., Heyman, Stephanie, Iacovella, Vittorio, Mejia, Amanda, Marinazzo, Daniele, Craddock, Cameron, Olivetti, Emanuele, Hanson, Jamie, Avesani, Paolo, Garyfallidis, Eleftherios, Stanzione, Daniel, Carson, James P., Henschel, Robert, Hancock, David Y., Stewart, Craig A., Schnyer, David, Eke, Damian, Poldrack, Russell A., George, Nathalie, Bridge, Holly, Sani, Ilaria, Freiwald, Winrich, Puce, Aina, Port, Nicholas, and Pestilli, Franco

Subjects
FOS: Computer and information sciences, Computer Science - Distributed, Parallel, and Cluster Computing, Quantitative Biology - Neurons and Cognition, FOS: Biological sciences, Neurons and Cognition (q-bio.NC), Distributed, Parallel, and Cluster Computing (cs.DC), Quantitative Biology - Quantitative Methods, Quantitative Methods (q-bio.QM)
Abstract

Neuroscience research has expanded dramatically over the past 30 years by advancing standardization and tool development to support rigor and transparency. Consequently, the complexity of the data pipeline has also increased, hindering access to FAIR (Findable, Accessible, Interoperabile, and Reusable) data analysis to portions of the worldwide research community. brainlife.io was developed to reduce these burdens and democratize modern neuroscience research across institutions and career levels. Using community software and hardware infrastructure, the platform provides open-source data standardization, management, visualization, and processing and simplifies the data pipeline. brainlife.io automatically tracks the provenance history of thousands of data objects, supporting simplicity, efficiency, and transparency in neuroscience research. Here brainlife.io's technology and data services are described and evaluated for validity, reliability, reproducibility, replicability, and scientific utility. Using data from 4 modalities and 3,200 participants, we demonstrate that brainlife.io's services produce outputs that adhere to best practices in modern neuroscience research.

Published
2023
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2. Correction: Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study

Author

Sakr, Fatemah A, Grothe, Michel J, Teipel, Stefan, Perry, George, Ritchie, Craig, Rojkova, Katrine, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S, Sporns, Olaf, Toschi, Nicola, Verdooner, Steven R, Dubois, Bruno, Vergallo, Andrea, Villain, Nicolas, Welikovitch, Lindsay A, Woodcock, Janet, Younesi, Erfan, Hampel, Harald, group, INSIGHT-preAD study, Initiative, Alzheimer Precision Medicine, Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Cavedo, Enrica, Boukerrou, Nadia, Chiesa, Patrizia, Colliot, Olivier, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Habert, Marie-Odile, Jelistratova, Irina, Houot, Marion, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Lista, Simone, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Potier, Marie-Claude, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, de Schotten, Michel Thiebaud, Younsi, Nadjia, Aguilar, Lisi Flores, Dyrba, Martin, Babiloni, Claudio, Baldacci, Filippo, Benda, Norbert, Black, Keith L, Bokde, Arun L W, Bonuccelli, Ubaldo, Broich, Karl, Bun, René S, Cacciola, Francesco, Castrillo, Juan, Gonzalez-Escamilla, Gabriel, Ceravolo, Roberto, Chiesa, Patrizia A, Coman, Cristina-Maria, Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L, Depypere, Herman, Duggento, Andrea, Durrleman, Stanley, Escott-Price, Valentina, Federoff, Howard, Ferretti, Maria Teresa, Fiandaca, Massimo, Frank, Richard A, Garaci, Francesco, George, Nathalie, Locatelli, Maxime, Giorgi, Filippo S, Graziani, Manuela, Haberkamp, Marion, Herholz, Karl, Karran, Eric, Kim, Seung H, Koronyo, Yosef, Koronyo-Hamaoui, Maya, Lehericy, Stephane, Langevin, Todd, Lehéricy, Stéphane, Lorenceau, Jean, Mapstone, Mark, Neri, Christian, Nisticò, Robert, Nyasse-Messene, Francis, and O'bryant, Sid E

Subjects
Neurology, Cognitive Neuroscience, ddc:610, Neurology (clinical)
Published
2022

3. Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints

Author

Cavedo, Enrica, Chiesa, Patrizia A., Houot, Marion, Ferretti, Maria Teresa, Grothe, Michel J., Teipel, Stefan J., Lista, Simone, Habert, Marie-Odile, Potier, Marie-Claude, Dubois, Bruno, Hampel, Harald, Bakardjian, Hovagim, Benali, Habib, Bertin, Hugo, Bonheur, Joel, Boukadida, Laurie, Boukerrou, Nadia, Chiesa, Patrizia, Colliot, Olivier, Dubois, Marion, Epelbaum, Stéphane, Gagliardi, Geoffroy, Genthon, Remy, Kas, Aurélie, Lamari, Foudil, Levy, Marcel, Metzinger, Christiane, Mochel, Fanny, Nyasse, Francis, Poisson, Catherine, Revillon, Marie, Santos, Antonio, Andrade, Katia Santos, Sole, Marine, Surtee, Mohmed, de Schotten, Michel Thiebaud, Vergallo, Andrea, Younsi, Nadjia, Aguilar, Lisi Flores, Babiloni, Claudio, Baldacci, Filippo, Benda, Norbert, Black, Keith L., Bokde, Arun L. W., Bonuccelli, Ubaldo, Broich, Karl, Bun, René S., Cacciola, Francesco, Castrillo, Juan, Ceravolo, Roberto, Coman, Cristina-Maria, Corvol, Jean-Christophe, Cuello, Augusto Claudio, Cummings, Jeffrey L., Depypere, Herman, Duggento, Andrea, Durrleman, Stanley, Escott-Price, Valentina, Federoff, Howard, Fiandaca, Massimo, Frank, Richard A., Garaci, Francesco, George, Nathalie, Giorgi, Filippo S., Graziani, Manuela, Haberkamp, Marion, Herholz, Karl, Karran, Eric, Kim, Seung H., Koronyo, Yosef, Koronyo-Hamaoui, Maya, Langevin, Todd, Lehéricy, Stéphane, Lorenceau, Jean, Mapstone, Mark, Neri, Christian, Nisticò, Robert, Nyasse-Messene, Francis, O'Bryant, Sid E., Perry, George, Ritchie, Craig, Rojkova, Katrine, Rossi, Simone, Saidi, Amira, Santarnecchi, Emiliano, Schneider, Lon S., Sporns, Olaf, Toschi, Nicola, Verdooner, Steven R., Villain, Nicolas, Welikovitch, Lindsay A., Woodcock, Janet, and Younesi, Erfan

Subjects
Male, 0301 basic medicine, Apolipoprotein E, Oncology, Aging, aging, Alzheimer's disease, amyloid, APOE, basal forebrain, cognitively intact older individuals, cortical thickness, FDG-PET, hippocampus, metabolism, sex, epidemiology, health policy, developmental neuroscience, neurology (clinical), geriatrics and gerontology, cellular and molecular neuroscience, psychiatry and mental health, Epidemiology, Cognitively intact older individuals, Precuneus, Hippocampus, genetics [Alzheimer Disease], physiopathology [Brain], Cohort Studies, 0302 clinical medicine, genetics [Memory Disorders], Risk Factors, Neural Pathways, Medicine, Aged, 80 and over, Sex Characteristics, Health Policy, Settore FIS/07, Neurodegeneration, Brain, Human brain, Magnetic Resonance Imaging, diagnostic imaging [Neural Pathways], Psychiatry and Mental health, metabolism [Glucose], medicine.anatomical_structure, Female, Sex, Amyloid, medicine.medical_specialty, Rest, diagnostic imaging [Memory Disorders], physiopathology [Alzheimer Disease], Cortical thickness, Basal forebrain, Diagnostic Self Evaluation, 03 medical and health sciences, Cellular and Molecular Neuroscience, Apolipoproteins E, Sex Factors, Developmental Neuroscience, Alzheimer Disease, Internal medicine, physiopathology [Memory Disorders], Humans, ddc:610, diagnostic imaging [Brain], Metabolism, Anterior cingulate cortex, metabolism [Amyloid], Aged, Memory Disorders, Resting state fMRI, business.industry, physiopathology [Neural Pathways], medicine.disease, Glucose, 030104 developmental biology, psychology [Memory Disorders], Positron-Emission Tomography, Posterior cingulate, genetics [Apolipoproteins E], Neurology (clinical), Geriatrics and Gerontology, business, diagnostic imaging [Alzheimer Disease], 030217 neurology & neurosurgery
Abstract

Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers.Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose-positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers.Men compared with women showed higher anterior cingulate cortex amyloid load (P = .009), glucose hypometabolism in the precuneus (P = .027), posterior cingulate (P .001) and inferior parietal (P = .043) cortices, and lower resting-state functional connectivity in the default mode network (P = .024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant.Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.

Published
2018

5. Methods for protein labeling based on acyl carrier protein

Author

Johnsson, Kai and George, Nathalie

Subjects
TTO:6.0426
Abstract

A method for labeling acyl carrier protein (ACP) fusion proteins with a wide variety of different labels is disclosed. The method relies on the transfer of a label from a coenzyme A type substrate to an ACP fusion protein using a holo-acyl carrier protein synthase (ACPS) or a homologue thereof. The method allows detecting and manipulating the fusion protein, both in vitro and in vivo, by attaching molecules to the fusion proteins that introduce a new physical or chemical property to the fusion protein. Examples of such labels are, among others, spectroscopic probes or reporter molecules, affinity tags, molecules generating reactive radicals, cross-linkers, ligands mediating protein-protein interactions or molecules suitable for the immobilization of the fusion protein.

7. Protective anti‐prion antibodies in human immunoglobulin repertoires

Author

Senatore, Assunta, Frontzek, Karl, Emmenegger, Marc, Chincisan, Andra, Losa, Marco, Reimann, Regina, Horny, Geraldine, Guo, Jingjing, Fels, Sylvie, Sorce, Silvia, Zhu, Caihong, George, Nathalie, Ewert, Stefan, Pietzonka, Thomas, Hornemann, Simone, and Aguzzi, Adriano

Subjects
3. Good health

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