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2. Nonlinear time-dependent mechanical behavior of mammalian collagen fibrils

Author

Fan Yang, Debashish Das, Kathiresan Karunakaran, Guy M. Genin, Stavros Thomopoulos, and Ioannis Chasiotis

Subjects
Biomaterials, Biomedical Engineering, General Medicine, Molecular Biology, Biochemistry, Biotechnology
Abstract

The viscoelastic mechanical behavior of collagenous tissues has been studied extensively at the macroscale, yet a thorough quantitative understanding of the time-dependent mechanics of the basic building blocks of tissues, the collagen fibrils, is still missing. In order to address this knowledge gap, stress relaxation and creep tests at various stress (5-35 MPa) and strain (5-20%) levels were performed with individual collagen fibrils (average diameter of fully hydrated fibrils: 253 ± 21 nm) in phosphate buffered saline (PBS). The experimental results showed that the time-dependent mechanical behavior of fully hydrated individual collagen fibrils reconstituted from Type I calf skin collagen, is described by strain-dependent stress relaxation and stress-dependent creep functions in both the heel-toe and the linear regimes of deformation in monotonic stress-strain curves. The adaptive quasilinear viscoelastic (QLV) model, originally developed to capture the nonlinear viscoelastic response of collagenous tissues, provided a very good description of the nonlinear stress relaxation and creep behavior of the collagen fibrils. On the other hand, the nonlinear superposition (NSP) model fitted well the creep but not the stress relaxation data. The time constants and rates extracted from the adaptive QLV and the NSP models, respectively, pointed to a faster rate for stress relaxation than creep. This nonlinear viscoelastic behavior of individual collagen fibrils agrees with prior studies of macroscale collagenous tissues, thus demonstrating consistent time-dependent behavior across length scales and tissue hierarchies. STATEMENT OF SIGNIFICANCE: Pure stress relaxation and creep experiments were conducted for the first time with fully hydrated individual collagen fibrils. It is shown that collagen nanofibrils have a nonlinear time-dependent behavior which agrees with prior studies on macroscale collagenous tissues, thus demonstrating consistent time-dependent behavior across length scales and tissue hierarchies. This new insight into the non-linear viscoelastic behavior of the building blocks of mammalian collagenous tissues may serve as the foundation for improved macroscale tissue models that capture the mechanical behavior across length scales.

Published
2023

5. Interorganizational Knowledge Flows in Academia–Industry Collaboration: The Economic Impacts of Science-Based Firm Innovation

Author

Moren Lévesque and Aurora Liu Genin

Subjects
Entrepreneurship, Generality, ComputingMilieux_THECOMPUTINGPROFESSION, Strategy and Management, media_common.quotation_subject, Moderation, Originality, Economic impact analysis, Business, Electrical and Electronic Engineering, Practical implications, Industrial organization, Panel data, media_common
Abstract

We investigate the double-edged impacts of interorganizational knowledge flows in academia–industry collaboration on the innovation economic impacts of science-based firms. When a firm receives knowledge directly from more research institutes, its innovation economic impact improves subsequently. In contrast, when a firm receives knowledge indirectly from other firms through a research institute, its innovation economic impact declines subsequently. We also explore the moderation effects of firm technological originality and generality. We report empirical findings from a panel data of science-based firms in the United States. Our analysis yields theoretical implications for academia–industry collaborations in the science-based entrepreneurship literature and practical implications for management practitioners and policymakers in science-based firm creation and development.

Published
2023

9. C’est ça, la laïcité ?

Author

Vincent Genin

Subjects
Sociology and Political Science, General Arts and Humanities, Political Science and International Relations, Religious studies
Published
2023

10. Early management of presbycusis: recommendations from the French Society of Otorhinolaryngology and Head and Neck Surgery, the French Society of Audiology, and the French Society of Geriatrics and Gerontology

Author

Hung Thai-Van, Isabelle Mosnier, François Dejean, Emmanuelle Ambert-Dahan, David Bakhos, Joël Belmin, Damien Bonnard, Stéphanie borel, Jean-Charles Ceccato, Arnaud Coez, Maxime Damien, Matthieu Del Rio, Mohamed El Yagoubi, Arnaud Genin, Auriane Gros, Mélanie Harichaux, Samar Idriss, Eugen Ionescu, Charles-Alexandre Joly, Pierre Krolak Salmon, Rémi Marianowski, Mathieu Marx, Thierry Mom, Cécile Parietti-Winkler, Morgan Potier, Christian Renard, Stéphane Roman, Thomas Roy, Sophie Tronche, Frédéric Venail, Christophe Vincent, Pierre Reynard, Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 (MBLC - ADDS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon

Subjects
Neuropsychology and Physiological Psychology, [SDV]Life Sciences [q-bio], Neurology (clinical), General Medicine, Geriatrics and Gerontology, Biological Psychiatry
Abstract

National audience; Introduction. La presbyacousie correspond à la diminution physiologique de l’audition due à l’avancée en âge et commence bien avant la sixième décennie. Ces recommandations rappellent les principes du diagnostic précoce de la presbyacousie et les moyens de réhabilitation optimale dès l’apparition des premiers symptômes. Matériel et méthodes. Les recommandations sont basées sur une analyse systématique de la littérature réalisée par un groupe multidisciplinaire réunissant des médecins, des audiologistes et des audioprothésistes provenant de toute la France. Elles sont classées en grade A, B, C ou accord professionnel selon un niveau de preuve scientifique décroissant. Résultats. Le diagnostic de presbyacousie est plus difficile en début d’évolution, mais un certain nombre d’outils sont disponibles pour son diagnostic précoce et sa prise en charge en présentiel, voire à distance. Conclusion. En cas de profil clinique évocateur de presbyacousie chez un sujet jeune, surtout s’il y a plusieurs cas familiaux, il est recommandé de proposer une enquête génétique. Il est recommandé de réaliser l’audiométrie vocale dans le bruit en champ libre pour mesurer l’intelligibilité dans un environnement au plus proche de la réalité. Les questionnaires en supplément de l’audiométrie permettraient d’évaluer au mieux le handicap du patient. Il est recommandé de considérer que la réhabilitation auditive par prothèse auditive ou implant cochléaire peut ralentir ou prévenir le déclin cognitif. Une rééducation combinée auditive et cognitive devrait être proposée, quel que soit le temps écoulé depuis l’appareillage. Il est recommandé d’intégrer des programmes accessibles par smartphones, tablettes ou Internet intégrant différents domaines d’entraînement en complément des séances en présentiel.

Published
2023

11. Efficient Construction of Involutory Linear Combinations of Anticommuting Pauli Generators for Large-Scale Iterative Qubit Coupled Cluster Calculations

Author

Ilya G. Ryabinkin, Andrew J. Jena, and Scott N. Genin

Subjects
Chemical Physics (physics.chem-ph), Quantum Physics, Physics - Chemical Physics, FOS: Physical sciences, Physical and Theoretical Chemistry, Quantum Physics (quant-ph), Computer Science Applications
Abstract

We present an efficient method for construction of a fully anti-commutative set of Pauli generators (elements of the Pauli group) from a commutative set of operators that are composed exclusively from Pauli $\hat x_i$ operators (purely X generators) and sorted by an associated numerical measure, such as absolute energy gradients. Our approach uses the Gauss-Jordan elimination applied to a binary matrix that encodes the set of X generators to bring it to the reduced row echelon form, followed by the construction of an anti-commutative system in a standard basis by means of a modified Jordan-Wigner transformation and returning to the original basis. The algorithm complexity is linear in the size of the X set and quadratic in the number of qubits. The resulting anti-commutative sets are used to construct the qubit coupled cluster Ansatz with involutory linear combinations of anti-commuting Paulis (QCC-ILCAP) proposed in [J. Chem. Theory Comput. 2021, 17, 1, 66-78]. We applied the iterative qubit coupled cluster method with the QCC-ILCAP Ansatz to calculations of ground-state potential energy curves for symmetric stretching of the water molecule (36 qubits) and dissociation of N$_2$ (56 qubits).

Published
2023

12. Differential clearance rates of microbial phylotypes by four appendicularian species

Author

A Dadon-Pilosof, K Conley, F Lombard, KR Sutherland, A Genin, M Richter, FO Glöckner, and G Yahel

Subjects
Ecology, Aquatic Science, Ecology, Evolution, Behavior and Systematics
Abstract

Appendicularians are abundant planktonic filter feeders that play a significant role in the pelagic food web due to their high clearance rates. Their diet and feeding rates have typically been measured as bulk chlorophyll or cell removal, with some attention given to prey size but no differentiation between the microbial phylotypes. Using a combination of in situ and laboratory incubations with flow cytometry and next-generation sequencing, we found species-specific differences in clearance rates and diet compositions of 4 common species: Oikopleura albicans, O. fusiformis, O. longicauda, and O. dioica. While O. albicans most efficiently removed nano-eukaryotic algae, the other smaller species preferentially removed micron-sized pico-eukaryotic algae. Pico- and nano-eukaryotic cells constituted the major food source of the studied appendicularians despite their occurrence in oligotrophic water dominated by prokaryotic cells. Across species, pico- and nano-planktonic microalgae biomass comprised 45 to 75% of the appendicularian diets. Although non-photosynthetic bacteria were removed at lower rates than all other prey groups, their total contribution to the appendicularian diet was not trivial, representing 5 to 19% of the planktonic carbon in the appendicularian diet; pico-cyanobacteria contributed an additional 9 to 18%. Removal rates and efficiencies of pico-eukaryotes were higher than those of prokaryotes of similar size. Strikingly different clearance rates were observed for different prokaryotic phylotypes, indicating that factors other than size are involved in determining the capturability of the cells. Collectively, our findings provide additional evidence for differential retention of microbial prey among mucous-mesh grazers and its substantial effect on the upper-ocean microbial community.

Published
2023

14. Rambutan seed waste-derived nitrogen-doped carbon dots with <scp>l</scp>-aspartic acid for the sensing of Congo red dye

Author

Muhammad Zulfajri, Sri Sudewi, Rizki Damayanti, and Genin Gary Huang

Subjects
General Chemical Engineering, General Chemistry
Abstract

In this study, new nitrogen-doped carbon dots (N-CDs) were prepared by utilizing rambutan seed waste and l-aspartic acid as dual precursors (carbon and nitrogen sources) through a hydrothermal treatment method and applied as a fluorescent sensor toward Congo red.

Published
2023

15. Self-assembly of amino-terminated monolayers depending on the chemical structure

Author

Lisa Rouvière, Axelle Hachin, Svitlana Shinkaruk, Julien Hunel, Christian Aupetit, Thierry Buffeteau, Emilie Genin, and Luc Vellutini

Subjects
Materials Chemistry, General Chemistry, Catalysis
Abstract

Preparation of well-defined amino-terminated monolayers using a direct grafting strategy with phthalimide as a protecting amino group.

Published
2023

16. 2022 French Report Card on Physical Activity and Sedentary Behaviors in Children and Youth: From Continuous Alarming Conclusions to Encouraging Initiatives

Author

Alicia Fillon, Jeremy Vanhelst, Pauline Genin, Benjamin Larras, Michéle Tardieu, Marion Porcherie, Maxime Luiggi, Salomé Aubert, Charlotte Verdot, Olivier Rey, Lena Lhuisset, Julien E. Bois, Guillaume Y. Millet, Martine Duclos, David Thivel, Centre de Recherche en Nutrition Humaine Auvergne [CHU Clermont-Ferrand] (CRNH A), Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Observatoire national de l’activité physique et de la sédentarité (ONAPS), Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques (AME2P), Université Clermont Auvergne (UCA)-UFR Sciences et Techniques des Activités Physiques et Sportives - Clermont-Auvergne (UFR STAPS - UCA), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherches sur l'Action Politique en Europe (ARENES), Université de Rennes (UR)-Institut d'Études Politiques [IEP] - Rennes-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Centre National de la Recherche Scientifique (CNRS), École des Hautes Études en Santé Publique [EHESP] (EHESP), Apprentissage, Didactique, Evaluation, Formation (ADEF), Aix Marseille Université (AMU), Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Université de Pau et des Pays de l'Adour (UPPA), Environnement, Santé/Stic (E2S), Université de Bourgogne (UB), Mouvement, Équilibre, Performance, Santé (MEPS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
[SDV]Life Sciences [q-bio], active transportation, Orthopedics and Sports Medicine, adolescents, physical activity promotion
Abstract

Background: Scientific evidence and public health reports keep highlighting the continuous and alarming worldwide progression of physical inactivity and sedentary behaviors in children and adolescents. The present paper summarizes findings from the 2022 French Report Card (RC) on physical activity for children and youth and compares them to the 2016, 2018, and 2020 RCs. Methods: The 2022 edition of the French RC follows the standardized methodology established by the Active Healthy Kids Global Matrix. Ten physical activity indicators have been evaluated and graded based on the best available evidence coming from national surveys, peer-reviewed literature, government and nongovernment reports, and online information. The evaluation was also performed in children and adolescents with disabilities. Indicators were graded from A (high level of evidence) to F (very low level of evidence) or INC for incomplete. Results: The evaluated indicators received the following grades: overall physical activity: D−; organized sport participation and physical activity: C; active play: F; active transportation: C; sedentary behaviors: D−; family and peers: D; physical fitness: C; school: C−; community and the built environment: F; government: B. Conclusions: While this 2022 French RC shows progression for 7 out of the 10 indicators considered, it also underlines the continuous need for actions at the local, regional, and national levels to develop better surveillance systems and favor a long-term improvement of youth movement behaviors.

Published
2023

19. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

Author

Holstege, Henne, Hulsman, Marc, Charbonnier, Camille, Grenier-Boley, Benjamin, Quenez, Olivier, Grozeva, Detelina, van Rooij, Jeroen G. J., Sims, Rebecca, Ahmad, Shahzad, Amin, Najaf, Norsworthy, Penny J., Dols Icardo, Oriol, Hummerich, Holger, Kawalia, Amit, Amouyel, Philippe, Beecham, Gary W., Berr, Claudine, Bis, Joshua C., Boland, Anne, Bossù, Paola, Bouwman, Femke, Bras, Jose, Campion, Dominique, Cochran, J. Nicholas, Daniele, Antonio, Dartigues, Jean-François, Debette, Stéphanie, Deleuze, Jean-François, Denning, Nicola, DeStefano, Anita L., Farrer, Lindsay A., Fernández, Maria Victoria, Fox, Nick C., Galimberti, Daniela, Genin, Emmanuelle, Gille, Johan J. P., Le Guen, Yann, Guerreiro, Rita, Haines, Jonathan L., Holmes, Clive, Ikram, M. Arfan, Ikram, M. Kamran, Jansen, Iris E., Kraaij, Robert, Lathrop, Marc, Lemstra, Afina W., Lleó, Alberto, Luckcuck, Lauren, Mannens, Marcel M. A. M., Marshall, Rachel, Martin, Eden R., Masullo, Carlo, Mayeux, Richard, Mecocci, Patrizia, Meggy, Alun, Mol, Merel O., Morgan, Kevin, Myers, Richard M., Nacmias, Benedetta, Naj, Adam C., Napolioni, Valerio, Pasquier, Florence, Pastor, Pau, Pericak-Vance, Margaret A., Raybould, Rachel, Redon, Richard, Reinders, Marcel J. T., Richard, Anne-Claire, Riedel-Heller, Steffi G., Rivadeneira, Fernando, Rousseau, Stéphane, Ryan, Natalie S., Saad, Salha, Sánchez-Juan, Pascual, Schellenberg, Gerard D., Scheltens, Philip, Schott, Jonathan M., Seripa, Davide, Seshadri, Sudha, Sie, Daoud, Sistermans, Erik A., Sorbi, Sandro, van Spaendonk, Resie, Spalletta, Gianfranco, Tesi, Niccolo, Tijms, Betty, Uitterlinden, André G., van der Lee, Sven J., Visser, Pieter Jelle, Wagner, Michael, Wallon, David, Wang, Li-San, Zarea, Aline, Clarimón, Jordi, van Swieten, John C., Greicius, Michael D., Yokoyama, Jennifer S., Cruchaga, Carlos, Hardy, John, Ramirez, Alfredo, Mead, Simon, van der Flier, Wiesje M., van Duijn, Cornelia M., Williams, Julie, Nicolas, Gaël, Bellenguez, Céline, Lambert, Jean-Charles, Universitat Autònoma de Barcelona, Internal Medicine, Neurology, Epidemiology, Amsterdam Neuroscience - Neurodegeneration, VU University medical center, Human genetics, General practice, Amsterdam Neuroscience - Brain Imaging, APH - Personalized Medicine, APH - Methodology, Complex Trait Genetics, Human Genetics, and ACS - Pulmonary hypertension & thrombosis

Subjects
Adenosine Triphosphatases, rare damaging variants, Membrane Transport Proteins, genetics [Alzheimer Disease], Alzheimer's disease, ATP8B4 protein, human, genetics [Adenosine Triphosphatases], genetics [Exosomes], Settore MED/26 - NEUROLOGIA, SDG 3 - Good Health and Well-being, Alzheimer Disease, Risk Factors, ddc:570, Genetics research, ABCA1 protein, human, Genetics, SORL1 protein, human, Humans, genetics [ATP Binding Cassette Transporter 1], LDL-Receptor Related Proteins, Genome-Wide Association Study, ATP Binding Cassette Transporter 1
Abstract

Alzheimer’s disease (AD), the leading cause of dementia, has an estimated heritability of approximately 70%1. The genetic component of AD has been mainly assessed using genome-wide association studies, which do not capture the risk contributed by rare variants2. Here, we compared the gene-based burden of rare damaging variants in exome sequencing data from 32,558 individuals—16,036 AD cases and 16,522 controls. Next to variants in TREM2, SORL1 and ABCA7, we observed a significant association of rare, predicted damaging variants in ATP8B4 and ABCA1 with AD risk, and a suggestive signal in ADAM10. Additionally, the rare-variant burden in RIN3, CLU, ZCWPW1 and ACE highlighted these genes as potential drivers of respective AD-genome-wide association study loci. Variants associated with the strongest effect on AD risk, in particular loss-of-function variants, are enriched in early-onset AD cases. Our results provide additional evidence for a major role for amyloid-β precursor protein processing, amyloid-β aggregation, lipid metabolism and microglial function in AD.

Published
2022

20. Impact on renal function of daily and on-demand HIV pre-exposure prophylaxis in the ANRS-PREVENIR study

Author

Geoffroy Liegeon, Lambert Assoumou, Jade Ghosn, Mayssam El Mouhebb, Romain Palich, Christia Palacios, Laurence Slama, Laure Surgers, Michèle Genin, Lydie Beniguel, Lauriane Goldwirt, Claudine Duvivier, Daniela Rojas Castro, Dominique Costagliola, and Jean-Michel Molina

Subjects
Male, Adult, Pharmacology, Microbiology (medical), Anti-HIV Agents, HIV Infections, Kidney, Sexual and Gender Minorities, Infectious Diseases, Humans, Emtricitabine, Pre-Exposure Prophylaxis, Pharmacology (medical), Homosexuality, Male, Retrospective Studies
Abstract

Objectives To assess the impact on the estimated glomerular filtration rate (eGFR) of different tenofovir disoproxil/emtricitabine dosing regimens for HIV pre-exposure prophylaxis (PrEP). Patients and methods We included in the study individuals with baseline eGFR > 50 mL/min/1.73 m2 who initiated PrEP in the ongoing ANRS-PREVENIR PrEP cohort. We retrospectively classified PrEP users in three groups: ‘on-demand’ (reported at ≥75% of study visits), ‘daily’ (≥75% of study visits) or ‘switches’. We compared the area under curve (AUC) of the eGFR variation from baseline (ΔeGFR) between groups using analysis of covariance, and assessed factors associated with a negative AUC of ΔeGFR. Results From May 2017 to October 2020, 1253 PrEP-naïve participants (98% of MSM) were included in the study with a median follow-up of 22 months. 499 (40%), 494 (39%) and 260 (21%) users were in the group daily, on-demand and switches, respectively, for a median number of pills taken per week of 6, 1.7 and 4. The mean AUC of the ΔeGFR was −1.09 mL/min/1.73 m2 in the daily PrEP group, −0.69 mL/min/1.73 m2 in the switches group and +0.18 mL/min/1.73 m2 with on-demand PrEP. In a model adjusted on baseline age and eGFR, the AUC of the ΔeGFR was significantly higher with on-demand PrEP compared to daily PrEP (P = 0.037). Independent factors associated with a negative AUC of ΔeGFR were a daily PrEP regimen, a switches regimen, an age > 40 years and a baseline eGFR≥90 mL/min/1.73 m². Conclusions On-demand PrEP dosing had a smaller impact on eGFR evolution than daily PrEP, but the difference was not clinically relevant.

Published
2022

21. Acoustic radiation force on a long cylinder, and potential sound transduction by tomato trichomes

Author

Xiangjun Peng, Yifan Liu, Wei He, Ethan D. Hoppe, Lihong Zhou, Fengxian Xin, Elizabeth S. Haswell, Barbara G. Pickard, Guy M. Genin, and Tian Jian Lu

Subjects
Solanum lycopersicum, Biophysics, Animals, Trichomes, Acoustics
Abstract

Acoustic transduction by plants has been proposed as a mechanism to enable just-in-time up-regulation of metabolically expensive defensive compounds. Although the mechanisms by which this "hearing" occurs are unknown, mechanosensation by elongated plant hair cells known as trichomes is suspected. To evaluate this possibility, we developed a theoretical model to evaluate the acoustic radiation force that an elongated cylinder can receive in response to sounds emitted by animals, including insect herbivores, and applied it to the long, cylindrical stem trichomes of the tomato plant Solanum lycopersicum. Based on perturbation theory and validated by finite element simulations, the model quantifies the effects of viscosity and frequency on this acoustic radiation force. Results suggest that acoustic emissions from certain animals, including insect herbivores, may produce acoustic radiation force sufficient to trigger stretch-activated ion channels.

Published
2022

22. ANALYTICAL CALCULATIONS INVOLVING MAGNETIC FIELDS OF A MAGNETOELECTRIC VALVE MOTOR USING THE METHOD OF SEPARATION OF VARIABLES

Author

Aleksandr A. Afanasyev, Valeriy S. Genin, and Nadezhda N. Ivanova

Subjects
General Medicine
Abstract

An analytical method for calculating the magnetic field of a magnetoelectric valve motor is considered based on the division of its active region into a set of geometrically homogeneous sheets, at the boundaries of which the conditions for conjugating their magnetic fields are met: scalar magnetic potentials and normal components of magnetic induction do not undergo a jump (break). As sources of the magnetic field, in addition to permanent magnets and currents of the stator winding, the magnetization of ferromagnetic sections of its magnetic circuit is provided. When using the Fourier method of separation of variables, the conjugation conditions will be reduced to solving a system of linear equations to find the corresponding constants. The solution of the system of parametric equations describing the design scheme of the inductor of a slotless magnetoelectric valve motor is given, in general terms using the Maxima analytical (symbolic) calculation package. The solution obtained makes it possible to use the results to describe the magnetic potentials and inductions of valve motors of various design geometries.

Published
2022

23. EFFECT OF ROTOR MISALIGNMENT ON MAGNETOELECTRIC VALVE MOTOR PERFORMANCE

Author

Aleksandr A. Afanasyev, Valeriy S. Genin, and Nadezhda N. Ivanova

Subjects
General Medicine
Abstract

A mathematical model of the magnetic field in the working clearance of a magnetoelectric valve motor is presented when the rotor is misaligned relative to the stator axis, which occurs during manufacture, for example, due to defects in bearing panels or during operation due to bearing wear. Using the conformal transformation of an uneven air gap into a uniform (circular ring), a study of the magnetic field in the air gap of the engine was carried out. A case is considered when the section of the air gap with the minimum size is stationary and is associated with a specific place on the surface of the stator boring. The serrature of the stator was taken into account on average using the Carter coefficient. The magnetic field in the inhomogeneous air gap created by the rotor magnets and the current of the stator winding was assumed to be plane-parallel, having a two-dimensional character. It is obtained that the misalignment of the rotor associated with the rotational motion of the air gap section with a minimum size leads to the appearance of non-sinusoidal EMF and pulsations of electromagnetic moment with a frequency exceeding 3p times the rotational speed of the rotor (p is the number of pairs of poles). With fixed eccentricity, an alternating EMF is induced along the rotor shaft, causing alternating current in the circuit: shaft – bearings – bearing panels – stator housing. Pulsations of the moment of the electromagnetic moment of the engine are caused by the appearance of mainly the 3rd and 9th harmonics, the values of which increase with increasing misalignment according to a law close to linear. The constant component of the electromagnetic moment increases somewhat with increasing misalignment.

Published
2022

25. Transition to Comfort Care Only and End-of-Life Trajectories in an Acute Geriatric Unit: A Secondary Analysis of the DAMAGE Cohort

Author

Guillaume Deschasse, Anne Charpentier, Chloé Prod'homme, Michaël Genin, Celine Delecluse, Cedric Gaxatte, Charlotte Gérard, Zsofi Bukor, Perrine Devulder, Louis-Antoine Couvreur, Frédéric Bloch, François Puisieux, Fabien Visade, Jean-Baptiste Beuscart, CHU Amiens-Picardie, Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Université Grenoble Alpes - UFR Médecine - Département de Maïeutique (UGA UFRMDM), Université Grenoble Alpes (UGA), CHU Lille, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Pôle de gérontologie [CHRU de Lille], Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 (LNFP), Université de Picardie Jules Verne (UPJV), and Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
Terminal Care, Frailty, Health Policy, General Medicine, Death, hospital admission, end-of-life trajectory, Palliative care, Humans, Prospective Studies, Patient Comfort, Geriatrics and Gerontology, transition to comfort care only, acute geriatric unit, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, General Nursing, Aged, dementia
Abstract

International audience; OBJECTIVES: Comfort care for a dying patient increases the quality of the end of life. End-of-life situations are frequently managed in acute geriatric units (AGUs), and transition to comfort care only is often necessary. However, the frequency of transition to comfort care and the latter's putative link with the end-of-life trajectory (sudden death, cancer, organ failure, and frailty with or without dementia) have not previously been studied in acute geriatric units. We sought to (1) describe end-of-life trajectories and the transition to comfort care only, and (2) analyse the relationship between the two, prior to death in an AGU. DESIGN: A secondary analysis of a subgroup of the DAMAGE cohort (a prospective multicentre cohort of 3509 patients aged 75~years and over and admitted consecutively to an AGU). SETTING/PARTICIPANTS: DAMAGE patients who died in an AGU after a stay of at least 48~hours. METHODS: Data on the end-of-life trajectory and the transition to comfort care only were extracted from medical records. RESULTS: Of the 177 included patients, 123 (69.5%) transitioned to comfort care only in the AGU. A frailty trajectory (in patients living with dementia or not) accounted for nearly 70% of deaths. Paradoxically, only frailty among people living without dementia was not significantly associated with a more frequent transition to comfort care [odds ratio (95% confidence interval): 1.44 (0.44-4.76), relative to a patient dying suddenly]. CONCLUSIONS AND IMPLICATIONS: Transition to comfort care only is frequent in AGUs and is linked to the end-of-life trajectory (except for frail patients living without dementia). The frailty trajectory is one of the most frequent, and, therefore, physicians must be aware of the need to improve practice in this context.

Published
2022

26. US Accreditation as a World-Class Education Quality Indicator

Author

Steve Parscale, Lester C. Reams, and Tatiana Andrienko-Genin

Abstract

On the turning point of European and world history, it is extremely important to unveil and effectively utilize the potential of effective high-quality education to make the future better for generations to come. Higher education quality management through accreditation has a long history of development in the United States, and time-proven standards, stimulating accredited institutions to continually improve academic quality. The concepts, systems, principles and practices of accreditation arouse in the United States out of the need to meet the demands for quality, and evolved over decades, to form a coherent set of standards and frameworks of continuous improvement in all meaningful directions of the educational institutions’ life, striving for teaching excellence and high learning outcomes. At present, accreditation principles and processes, as exemplified by the Accreditation Council for Business Schools and Programs (ACBSP) programmatic accreditation, are implemented in the US and numerous countries of the world, to ensure high standard and continuous improvement of business education quality, to raise the competitiveness of educational institutions in response to the expectations of public (primarily, students and their families), governments, employers, universities/colleges, academics, and broader communities. This study establishes the correlation of the quality management system via ACBSP accreditation with the continuous improvement of business education quality. This study also provides statistical evidence that the application of quality management principles at institutions of higher education with accredited business programs did result in the association with enhanced student learning outcomes. Higher education quality management leads to higher employability of the institution’s graduates. Since the quality of education is crucial for the country’s economic growth and prosperity, the business education institutions and programs in Ukraine and other Central and Eastern European and Eurasian countries may benefit from implementing quality management through ACBSP accreditation for their undergraduate, graduate, and postgraduate (doctoral) business programs, to satisfy ever-rising expectations of candidates for top managerial and leadership positions. The research suggests that 51% of the institutions of higher education with business programs in the United States, and 93% of the institutions of higher education worldwide could benefit from implementing accreditation principles and processes to maintain and enhance their education quality and competitiveness in the world business education market, for the sake of highest recognition of their graduates’ diploma on the global job markets and significant increase of their employability.

Published
2022

27. High-dose influenza vaccine is associated with reduced mortality among older adults with breakthrough influenza even when there is poor vaccine-strain match

Author

Sandra S Chaves, Sarah Naeger, Kahina Lounaci, Yue Zuo, Matthew M Loiacono, Quentin Pilard, Joshua Nealon, Marie Genin, and Cedric Mahe

Subjects
Microbiology (medical), Infectious Diseases
Abstract

Background High-dose (HD) influenza vaccine offers improved protection from influenza virus infection among older adults compared with standard-dose (SD) vaccine. Here we explored whether HD vaccine attenuates disease severity among older adults with breakthrough influenza. Methods Retrospective cohort study among adults ≥65 years from U.S. claims data, for seasons 2016-17, 2017-18 and 2018-19 defined as October 1st through April 30th. After adjusting the different cohorts for the probability of vaccination conditional on patients’ characteristics, we compared 30-day mortality rate post-influenza among older adults experiencing breakthrough infection after receipt of HD or SD influenza vaccines and among those not vaccinated (NV). Results We evaluated 44,456 influenza cases: 23,109 (52%) were unvaccinated, 15,037 (33.8%) received HD vaccine and 6,310 (14.2%) received SD vaccine. Significant reductions in mortality rates among breakthrough cases were observed across all three seasons for HD vs NV, ranging from 17-29% reductions. A significant mortality reduction of 25% was associated with SD vaccination vs. NV in the 2016-17 season, when there was a good match between circulating influenza viruses and selected vaccine strains. When comparing HD vs. SD cohorts, mortality reductions were higher among those receiving HD in the last two seasons, when mismatch between vaccine strains and circulating H3N2 viruses were documented, albeit not significant. Conclusion HD vaccination was associated with lower post-influenza mortality among older adults with breakthrough influenza, even during seasons where antigenically drifted H3N2 circulated. Improved understanding of the impact of different vaccines on attenuating disease severity is warrant when assessing vaccine policy recommendations.

Published
2023

29. Transcriptomic profiling reveals host-specific evolutionary pathways promoting enhanced fitness in the broad host range pathogenRalstonia pseudosolanacearum

Author

Rekha Gopalan-Nair, Françoise Jardinaud, Ludovic Legrand, Céline Lopez-Roques, Olivier Bouchez, Stéphane Genin, and Alice Guidot

Abstract

The impact of host diversity on the genotypic and phenotypic evolution of broad-spectrum pathogens is a remaining issue. Here, we used populations of the plant pathogenRalstonia pseudosolanacearumthat were experimentally evolved on five types of host plants, either belonging to different botanical families or differing in their susceptibility or resistance to the pathogen. We investigated whether changes in transcriptomic profiles dissociated from genetic changes could occur during the process of host adaptation, and whether transcriptomic reprogramming was dependent on host type. Genomic and transcriptomic variations were established for 31 evolved clones that showed a better fitness in their experimental host than the ancestral clone. Few genomic polymorphisms were detected in these clones, but significant transcriptomic variations were observed, with a high number of differentially expressed genes (DEGs). In a very clear way, a group of genes belonging to the network of regulation of the bacterial virulence such asefpR, efpHorhrpB, among others, were deregulated in several independent evolutionary lineages and appeared to play a key role in the transcriptomic rewiring observed in evolved clones. A double hierarchical clustering based on the 400 top DEGs for each clone revealed two major patterns of gene deregulation that depend on host genotype, but not on host susceptibility or resistance to the pathogen. This work therefore highlights the existence of two major evolutionary paths that result in a significant reorganization of gene expression during adaptive evolution and underscore clusters of co-regulated genes associated to bacterial adaptation on different host lines.

Published
2023

30. RapaCaspase-9-based suicide gene applied to the safety of IL-1RAP CAR-T cells

Author

Lucie Bouquet, Elodie Bôle-Richard, Walid Warda, Mathieu Neto Da Rocha, Rim Trad, Clémentine Nicod, Rafik Haderbache, Delphine Genin, Christophe Ferrand, and Marina Deschamps

Subjects
Genetics, Molecular Medicine, Molecular Biology
Abstract

Even if adoptive cell transfer (ACT) has already shown great clinical efficiency in different types of disease, such as cancer, some adverse events consistently occur, and suicide genes are an interesting system to manage these events. Our team developed a new medical drug candidate, a chimeric antigen receptor (CAR) targeting interleukin-1 receptor accessory protein (IL-1RAP), which needs to be evaluated in clinical trials with a clinically applicable suicide gene system. To prevent side effects and ensure the safety of our candidate, we devised two constructs carrying an inducible suicide gene, RapaCasp9-G or RapaCasp9-A, containing a single-nucleotide polymorphism (rs1052576) affecting the efficiency of endogenous caspase 9. These suicide genes are activated by rapamycin and based on the fusion of human caspase 9 with a modified human FK-binding protein, allowing conditional dimerization. RapaCasp9-G- and RapaCasp9-A-expressing gene-modified T cells (GMTCs) were produced from healthy donors (HDs) and acute myeloid leukemia (AML) donors. The RapaCasp9-G suicide gene demonstrated better efficiency, and we showed its in vitro functionality in different clinically relevant culture conditions. Moreover, as rapamycin is not pharmacologically inert, we also demonstrated its safe use as part of our therapy.

Published
2023

34. PLASMONIC PHOTOTHERMAL THERAPY IN EXPERIMENTAL ONCOLOGY: PROBLEMS AND PROSPECTS

Author

Tuchin, V.V., Genina, E.A., Genin, V.D., Khlebtsov, B.N., Khlebtsov, N.G., Mudrak, D.A., Navolokin, N.A., Maslyakova, G.N., and Bucharskaya, A.B.

Abstract

Despite great advances in the treatment of cancer, the effectiveness of standard chemotherapy and radiation therapy for some malignant neoplasms remains insufficient. Plasmonic photothermal therapy (PPT) with plasmon resonance gold nanoparticles has been an intensively researched area in therapy in recent years [1, 2]. Successful PPT with nanoparticles for tumor treatment requires solving a number of problems associated with the potential toxicity and the bio-distribution of nanoparticles, including the development of the most efficient method of nanoparticle delivery, as well as optimization of their therapeutic protocol.

Published
2022

35. Directed cell migration towards softer environments

Author

Aleksi Isomursu, Keun-Young Park, Jay Hou, Bo Cheng, Mathilde Mathieu, Ghaidan A. Shamsan, Benjamin Fuller, Jesse Kasim, M. Mohsen Mahmoodi, Tian Jian Lu, Guy M. Genin, Feng Xu, Min Lin, Mark D. Distefano, Johanna Ivaska, and David J. Odde

Subjects
Cell Movement, Mechanics of Materials, Mechanical Engineering, General Materials Science, Actomyosin, General Chemistry, Condensed Matter Physics, Biomechanical Phenomena
Abstract

How cells sense tissue stiffness to guide cell migration is a fundamental question in development, fibrosis and cancer. Although durotaxis-cell migration towards increasing substrate stiffness-is well established, it remains unknown whether individual cells can migrate towards softer environments. Here, using microfabricated stiffness gradients, we describe the directed migration of U-251MG glioma cells towards less stiff regions. This 'negative durotaxis' does not coincide with changes in canonical mechanosensitive signalling or actomyosin contractility. Instead, as predicted by the motor-clutch-based model, migration occurs towards areas of 'optimal stiffness', where cells can generate maximal traction. In agreement with this model, negative durotaxis is selectively disrupted and even reversed by the partial inhibition of actomyosin contractility. Conversely, positive durotaxis can be switched to negative by lowering the optimal stiffness by the downregulation of talin-a key clutch component. Our results identify the molecular mechanism driving context-dependent positive or negative durotaxis, determined by a cell's contractile and adhesive machinery.

Published
2022

36. Differences in Glenohumeral Range of Motion and Humeral Torsion Between Right-Handed and Left-Handed Professional Baseball Pitchers

Author

Jeremy, Harris, Jacob, Maier, Jonathan, Freeston, Lonnie, Soloff, Daniel, Himmerick, Andrew, Pipkin, Jason A, Genin, Mark S, Schickendantz, and Salvatore J, Frangiamore

Subjects
Cross-Sectional Studies, Shoulder Joint, Humans, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, Humerus, Range of Motion, Articular, Baseball
Abstract

Background: Elite pitchers have demonstrated significant differences in glenohumeral range of motion and humeral torsion compared with the nonthrowing population. Furthermore, abnormal shoulder range of motion measurements have been associated with different injury risks and challenges in assessing rehabilitation progress. Variations in range of motion and torsion due to handedness in the asymptomatic professional population have yet to be investigated in the literature. Hypothesis: No significant differences in glenohumeral range of motion and humeral torsion would exist between asymptomatic right- and left-handed professional pitchers. Study Design: Cross-sectional study; Level of evidence, 3. Methods: 217 Major League Baseball pitchers from a single organization were evaluated over a 7-year period between 2013 and 2020. Range of motion was measured with a standard goniometer. Ultrasound scanning was used to determine neutral position of the shoulder, and the degree of humeral torsion was measured with a goniometer. Results: Right-handed pitchers demonstrated significantly greater values of glenohumeral external rotation (118.5° vs 112.7°; P < .001) in their throwing arms compared with their left-handed counterparts. Right-handed pitchers also showed greater values of glenohumeral internal rotation deficit (13.9° vs 4.8°; P < .001) and side-to-side differences in humeral retrotorsion (−23.1° vs −2.2°; P < .001). Left-handed pitchers demonstrated significantly greater flexion deficits in the throwing arm compared with their right-handed counterparts (7.5° vs 0.0°; P < .001). Conclusion: In the throwing arm, right-handed pitchers demonstrated significantly greater measures of external rotation, glenohumeral internal rotation deficit, and humeral retrotorsion compared with left-handed counterparts. Furthermore, right-handed pitchers demonstrated a significant side-to-side difference in retrotorsion, whereas left-handed pitchers did not. However, left-handed pitchers demonstrated a side-to-side shoulder flexion deficit that was not present in the cohort of right-handed pitchers. The correlation between humeral retrotorsion and increased external rotation indicates that osseous adaptations may play a role in range of motion differences associated with handedness. Additionally, these findings may explain observed differences in several throwing metrics between right- and left-handed pitchers. Knowledge of these differences can inform rehabilitation programs and shoulder maintenance regimens.

Published
2022

37. On the Importance of Well-Defined Thermal Correlation Functions in Simulating Vibronic Spectra

Author

Rami Gherib, Scott N. Genin, and Ilya G. Ryabinkin

Subjects
Chemical Physics (physics.chem-ph), Physics - Chemical Physics, FOS: Physical sciences, Physical and Theoretical Chemistry
Abstract

Two difficulties associated with the computations of thermal vibrational correlation functions are discussed. The first one is the lack of a well-behaved expression that is valid at both high-temperature and $T \to 0$ K limits. Specifically, if the partition function and the propagator are considered separately, then thermal vibrational correlation functions may have an indeterminate form 0/0 in the limit $T \to 0$ K. This difficulty is resolved when the partition function and the propagator are jointly considered in the harmonic approximation, which allows a problematic term that emanates from the zero-point energy to be cancelled out thereby producing a thermal correlation function with a determinate form in $T \to 0$ K limit. The second difficulty is related to the multivaluedness of the vibrational correlation function. We show numerically that an improper selection of branch leads to discontinuities in the computed correlation function and an incorrect vibronic spectra. We propose a phase tracking procedure that ensures continuity of both real and imaginary parts of the correlation function to recover the correct spectra. We support our findings by simulating the UV-vis absorption spectra of pentacene at 4 K and benzene at 298 K. Both are found to be in good agreement with their experimental counterparts.

Published
2022

38. A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo

Author

G. Pagliaroli, Kevin Barkett, Denis Martynov, Marco Bazzan, C. Ingram, L. Pinard, Nicolas Sanchis-Gual, I. Belahcene, A. K. Y. Li, Archana Pai, F. Paoletti, P. Ruggi, G. Vajente, S. M. Gaebel, C. Kr mer, K. W. Chung, I. Dorrington, I. Di Palma, A. Mullavey, T. J. N. Nelson, Filip Morawski, Xiaohui Fan, Richard O'Shaughnessy, B. Barr, B. D. Lackey, G. Eddolls, A. Cumming, P. Grassia, Kipp Cannon, F. Di Renzo, M. Steinke, Francesco Pannarale, Soichiro Morisaki, D. Ugolini, P. Clearwater, M. Haney, T. A. Callister, Zhihui Du, G. Ciani, Alessandro Bertolini, Olivier Minazzoli, M. Razzano, Mairi Sakellariadou, G. Pillant, S. H. R. Yuen, O. de Varona, A. L. Stuver, R. De Rosa, I. Nardecchia, M. Kasprzack, J. Baird, Frances Hellman, M. B. Shaner, Manel Molina-Ruiz, S. B. Coughlin, Jessica Steinlechner, A. Neunzert, M. Heurs, Reed Essick, S. Kandhasamy, B. Sorazu, A. Kutynia, Andrea Chincarini, T. Z. Summerscales, Tenglin Li, Robert J. McCarthy, Linqing Wen, D. Meacher, Leo Tsukada, E. Z. Hamilton, A. Parida, S. S. Eikenberry, E. Genin, D. Estevez, W. Katzman, B. Grace, S. M. Aronson, M. Llorens-Monteagudo, M. Nery, Ryan Lynch, Ettore Majorana, D. M. Wilken, A. Rocchi, B. Goncharov, R. Birney, P. Ehrens, Paul M. Ricker, E. J. Fauchon-Jones, M. Lormand, William Parker, D. J. Stops, J. S. H. Lee, Felix Wellmann, Shreya Anand, D. Huet, S. H. Huttner, Z. Tornasi, Andrew Melatos, M. Lorenzini, M. Bitossi, J.-G. Ducoin, J. Neilson, G. Bergmann, K. Wette, John J. Oh, Timothy Evans, M. G. Benjamin, E. Payne, Rory Smith, C. Adams, R. M. Blair, D. Sigg, S. W. Ballmer, Z. Yang, D. M. Shoemaker, Michelle E. Walker, J. Eichholz, G. Moreno, H. Inchauspe, J. Liu, A. Pasqualetti, M. Tse, D. M. Macleod, B. L. Swinkels, J. Warner, R. Passaquieti, C. Rajan, O. Durante, N. Krupinski, F. Martelli, Karan Jani, Jade Powell, V. Mangano, H. K. Gulati, David H. Reitze, Rahul Kashyap, C. McIsaac, Nergis Mavalvala, A. K. Lenon, S. Mastrogiovanni, P. A. Altin, Piotr Jaranowski, Florent Robinet, J. Zhang, F. Baldaccini, L. F. Ortega, Jerome Degallaix, R. C. Walet, V. P. Mitrofanov, Rosa Poggiani, V. Frey, T. Sadecki, V. Tiwari, Yann Bouffanais, A. C. Green, C. Casentini, R. Shink, E. Goetz, F. Magaña-Sandoval, J. McIver, Sebastian Khan, B. C. Barish, J. H. Briggs, Mark Hannam, L. Rei, Gijs Nelemans, Tanja Hinderer, Alejandro Torres-Forné, A. K. Zadrożny, P.H. Nguyen, V. Boschi, E. J. Son, M. van Beuzekom, S. Grunewald, R. Prasanna, A. Ain, Shubhanshu Tiwari, G. A. Prodi, R. DeSalvo, V. Kondrashov, F. Frasconi, A. K. Mehta, E. D. Hall, S. Farinon, E. Mejuto Villa, D. Barker, A. Samajdar, Jolien D. E. Creighton, A. Pele, D. Singh, Arunava Mukherjee, Fausto Acernese, J. C. Barayoga, B. F. Neil, R. Flaminio, Richard J. Abbott, D. W. Yeeles, Hartmut Grote, D. C. Vander-Hyde, P. Puppo, W. Del Pozzo, Y. Minenkov, P. Bacon, P. F. Cohadon, H. Heitmann, A. Strunk, N. Kijbunchoo, Piero Rettegno, K. A. Santiago, P. J. Sutton, M. Cieślar, Maria Ilaria Del Principe, P. Raffai, J. C. Bayley, H. Wittel, M. Deenadayalan, G. H. Ogin, T. J. Shaffer, Marcus E. Lower, L. Glover, G. Losurdo, S. Biscoveanu, O. V. Palashov, Sean T. McWilliams, F. Piergiovanni, Chang-Hwan Lee, D. E. Cohen, M. Agathos, J. H. Romie, S. Sitmukhambetov, G. Kuehn, K. Merfeld, M. Ar ne, M. Phelps, Archisman Ghosh, R. G. Ormiston, Andrew Matas, A. Chiummo, K. Holt, M. Mantovani, E. A. Huerta, A. Ramos-Buades, S. L. Danilishin, Tristan Briant, R. K. Lanza, P. Dupej, Sheelu Abraham, Eric B. Flynn, J. Betzwieser, Antoine Heidmann, J. Hanks, A. Sur, H. Overmier, R. Goetz, Tarun Souradeep, J. P. Zendri, L. Sun, C. De Rossi, D. Buskulic, Odylio D. Aguiar, James Healy, P. Brockill, Luca Gammaitoni, R. Fittipaldi, C. Horst, Alberto Vecchio, F. Cipriano, Michael Thomas, R. Tenorio, N. A. Holland, D. Sellers, P. Popolizio, Koji Arai, F. J. Raab, Devon S. Johnson, N. Mukund, L. R. Cominsky, Neil J. Cornish, Colm Talbot, Andreas Freise, M. Davier, Sebastiano Bernuzzi, O. Halim, S. Koley, M. Brinkmann, C. Affeldt, S. Appert, Y. Setyawati, E. J. Sanchez, Nicholas Demos, J. D. Lough, D. Pascucci, H. S. Chen, L. E. H. Datrier, M. Bawaj, R. L. Savage, A. S. Bell, M. Laxen, Anchal Gupta, J. Meidam, M. Gosselin, Riccardo Sturani, M. K. M. Bader, O. Chaibi, Wolfango Plastino, R. Taylor, C. L. Romel, Giovanni Carapella, P. Shawhan, I. Ferrante, Soma Mukherjee, Charalampos Markakis, G. Mo, J. K. Blackburn, C. J. Richardson, F. L. Linde, E. Chassande-Mottin, Sylvain Marsat, Sheila Rowan, B. Gateley, Howard Pan, Aaron Buikema, R. Kirchhoff, B. L. Pearlstone, V. Fafone, Paul D. Lasky, R. K. Hasskew, Jordan Camp, D. Tao, M. Muratore, M. C. Heintze, D. Sentenac, F. Carbognani, Patrick Brady, P. Fulda, J. M. Fishner, Will M. Farr, M. Montani, Nancy Aggarwal, R. Gustafson, A. Grimaldi, J. W. Westhouse, Matthew Pitkin, F. Lin, Tania Regimbau, Serena Vinciguerra, F. Garufi, Chandra Kant Mishra, Joseph D. Romano, R. Bhandare, R. Pedurand, Benno Willke, C. C. Wipf, V. Pierro, M. J. Cowart, I. Dave, Lee McCuller, O. J. Piccinni, Takuya Tsutsui, T. D. Abbott, Zoheyr Doctor, M. Fletcher, B. Hughey, K. W. Tsang, P. J. Veitch, M. Rakhmanov, Surendra Nadh Somala, Gregorio Carullo, R. Xu, C. Buy, M. Oliver, Kazuhiro Agatsuma, T. J. Hansen, N. Bode, Christopher P. L. Berry, T. Harder, Rico K. L. Lo, P. Charlton, Kejia Lee, Patrick Das Gupta, S. E. Barclay, J. L. Willis, M. Eisenmann, Ofek Birnholtz, John A. Clark, Ben Farr, W. S. Kim, Christophe Collette, L. Kuo, H. Yamamoto, J. C. Driggers, A. Schönbeck, B. Rajbhandari, Daniel Wysocki, J. Prasad, A. J. Pedersen, S. B. Anderson, Tim Dietrich, M. Pürrer, S. Kwang, Frank Ohme, Vicky Kalogera, K. Rose, M. Tonelli, E. Katsavounidis, Xiuling Li, R. Gray, Patrick Godwin, M. C. Araya, Srishti Tiwari, S. Frasca, Jonathan Richardson, Tyson Littenberg, Kai Staats, L. Conti, M. Chaturvedi, Yu Huang, Geert Raaijmakers, F. Y. Khalili, R. P. Fisher, A. Allocca, D. I. Jones, Guoying Zhao, Kendall Ackley, R. K. Nayak, S. Raja, H. Y. Chia, Sascha Husa, S. E. Strigin, S. Mitra, M. Granata, H. J. Bulten, Minchuan Zhou, Shao-Jiang Wang, T. D. Creighton, S. E. Gossan, Dániel Barta, G. Venugopalan, Karl Gill, V. Srivastava, M. Fays, S. Barnum, S. C. Tait, K. Shukla, Zifan Zhou, I. A. Bilenko, L. Haegel, D.B. DeBra, David J. Ottaway, C. J. Perez, Matthew Evans, B. D. O'Brien, Marek Szczepanczyk, C. Bradaschia, M. Standke, Deep Jariwala, C. Cahillane, Otto A. Hannuksela, C. Gray, H. Estelles, W. A. Campbell, H. Radkins, A. Bozzi, N. N. Janthalur, L. Wallace, A. Królak, R. Frey, E. A. Muñiz, B. Sassolas, S. Brunett, Monica Colpi, Albino Perego, A. Bisht, M. Boer, J. B. Kanner, Andrew Lundgren, S. Xiao, J. V. Vanheijningen, D. Fiorucci, Zachariah B. Etienne, D. Moraru, E. Floden, Jennifer Watchi, A. K. Prajapati, Gianpietro Cagnoli, A. R. Wade, A. Di Lieto, S. J. Chamberlin, M. Vasúth, C. M. Mow-Lowry, Sergey P. Vyatchanin, Jonathan Cripe, V. Bossilkov, A. Paoli, Ik Siong Heng, A. Rüdiger, R. Inta, Steven Bloemen, Jonathan R. Gair, S. Klimenko, Eric Howell, E. Cesarini, S. Márka, N. Sennett, Stephen Fairhurst, Carl Blair, V. Fiumara, M. F. Carney, C. Lazzaro, Patricia Schmidt, Ajay Kumar, Y. K. Lecoeuche, M. J. Yap, C. Whittle, Bala R. Iyer, Stefan Grimm, D. B. Tanner, Kevin M. Ryan, S. McCormick, C. Difronzo, G. M. Harry, C. Palomba, S. Ascenzi, A. L. Miller, K. Venkateswara, L. Aiello, R. Green, Giuseppe Intini, Kenneth A. Strain, Jimin George, M. Sieniawska, Gregory Ashton, K. Chakravarti, G. Valdes, Ken K. Y. Ng, E. E. Cowan, B. D'Angelo, Hongyu Shen, D. C. Coyne, T. Dal Canton, J. Casanueva Diaz, P. Couvares, H. Fong, G. Greco, J. Zweizig, M. S. Shahriar, M. Korobko, J. Brooks, K. Siellez, Shiuh Chao, C. Périgois, P. Astone, Carlos O. Lousto, T. Hardwick, D. Steinmeyer, David Coward, A. Miani, R. Cotesta, Rakesh Kumar, F. Travasso, Yuri Levin, T. P. Downes, Gor Oganesyan, A. F. Brooks, P. J. Quinonez, Fabio Marchesoni, P. Hello, J. Gniesmer, Kyungmin Kim, Debarati Chatterjee, A. Trovato, B. O'Reilly, P. Gruning, Sheon Chua, R. Bonnand, C. North, Mariana Fazio, F. Vetrano, Samuele Cortese, Thomas Dent, P. Corban, S. J. Cooper, S. Leavey, Hai-Ping Cheng, A. Iess, M. Pedraza, M. Chan, Francesco Chiadini, Michał Bejger, Charlie Hoy, P. Schale, J. Jiang, J. Hennig, J. Junker, C. Van Den Broeck, E. Sowell, V. Gayathri, V. Hui, S. Walsh, Miriam Cabero, Alexander C. Jenkins, A. Markowitz, Robert Stone, M. Was, M. M. Hanke, G. Cho, James Whelan, P. Ajith, P. Booker, A. Perreca, G. Gemme, M. Drago, M. Di Giovanni, A. Malik, S. Gaudio, G. Dálya, T. Prestegard, J. Scott, L. K. Nuttall, A. W. Jones, Alessandro Nagar, R. De Pietri, Rocco Romano, M. Kinley-Hanlon, Lindsay DeMarchi, K. A. Thorne, E. L. Merilh, S. E. Dwyer, David Keitel, L. Matone, Mandar Patil, Guenakh Mitselmakher, B. A. Boom, A. M. Sergeev, Karsten Danzmann, A. R. Williamson, H. Vocca, Mario Spera, Peter Aufmuth, Andrea H. Tapia, Hua Wang, F. Cavalier, A. Bals, Yang Yang, S. G. Crowder, J. Bosveld, N. Koper, S. Kaufer, C. I. Torrie, Jan Harms, A. S. Sengupta, Xing-Jiang Zhu, Rana X. Adhikari, R. A. Mercer, S. Ossokine, Jinsook Kim, Om Sharan Salafia, C. K. Cheong, A. Lartaux-Vollard, M. Punturo, Leopoldo Milano, Slawomir Gras, L. Sammut, F. Muciaccia, Anupam Sharma, Lionel London, Moritz Mehmet, S. W. S. Ng, Suvadeep Bose, R. Gouaty, Debnandini Mukherjee, B. Idzkowski, V. Loriette, V. Skliris, R. Macas, G. Billingsley, S. Macfoy, Rainer Weiss, Alessandra Buonanno, R. Metzdorff, Isabel Cordero-Carrión, R. A. Eisenstein, Hee-Suk Cho, Gabrielle Allen, J.-M. Isac, B. Irwin, F. Donovan, S. Doravari, F. Ricci, W. Z. Korth, R. Kennedy, G. Fronz, F. Aubin, G. Stratta, László Á. Gergely, A. Macquet, Jishnu Suresh, G. D. Meadors, P. G. Murray, A. K. Divakarla, S. J. Kapadia, J. M. Gonzalez Castro, Z. Márka, Daichi Tsuna, Geoffrey Lovelace, M. Merzougui, Innocenzo M. Pinto, Haocun Yu, E. Biggs, L. Zhang, T. Zelenova, Riccardo Bassiri, Sebastian Steinlechner, C. A. Rose, X. Liu, Torrey Cullen, Magnus Manske, Bernard F. Whiting, Jesper Munch, Fabien Kéfélian, J. H. Hough, P. W. F. Forsyth, S. R. Thondapu, Chris A. Collins, Achamveedu Gopakumar, M. De Laurentis, M. Bischi, M. C. Milovich-Goff, J. L. Wright, J. R. Palamos, P. T. Baker, Carl-Johan Haster, Alessandra Corsi, D. Laghi, S. D'Antonio, E. Maros, P. B. Covas, L. Rolland, N. Letendre, B. D. Cheeseboro, B. Lantz, David Blair, P. J. Easter, K. Mogushi, Michele Zanolin, I. Magaña Hernandez, T. J. Massinger, Kiran Prasai, M. Khursheed, L. Naticchioni, D. Töyr, G. Vedovato, D. B. Kozak, F. Brighenti, Aniello Grado, D. Stocks, C. Vorvick, T. Vo, E. J. Daw, Salvatore Vitale, P. J. King, G. D. Hammond, K. H. Lai, Aaron Viets, Javed Rana, Abhirup Ghosh, G. Kang, A. L. Urban, Maurizio Canepa, J. Feicht, Satya Mohapatra, Antonio Marquina, L. Errico, T. A. Ferreira, K. D. Giardina, E. M. Santos, Nikhil Sarin, Martin Obergaulinger, M. Mondin, F. 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Lartaux-Vollard, A, Lasky, P, Laxen, M, Lazzarini, A, Lazzaro, C, Leaci, P, Leavey, S, Lecoeuche, Y, Lee, C, Lee, H, Lee, J, Lee, K, Lehmann, J, Lenon, A, Leroy, N, Letendre, N, Levin, Y, Li, A, Li, J, Li, K, Li, T, Li, X, Lin, F, Linde, F, Linker, S, Littenberg, T, Liu, J, Liu, X, Llorens-Monteagudo, M, Lo, R, London, L, Longo, A, Lorenzini, M, Loriette, V, Lormand, M, Losurdo, G, Lough, J, Lousto, C, Lovelace, G, Lower, M, Luck, H, Lumaca, D, Lundgren, A, Lynch, R, Ma, Y, Macas, R, Macfoy, S, Macinnis, M, Macleod, D, Macquet, A, Hernandez, I, Magana-Sandoval, F, Magee, R, Majorana, E, Maksimovic, I, Malik, A, Man, N, Mandic, V, Mangano, V, Mansell, G, Manske, M, Mantovani, M, Mapelli, M, Marchesoni, F, Marion, F, Marka, S, Marka, Z, Markakis, C, Markosyan, A, Markowitz, A, Maros, E, Marquina, A, Marsat, S, Martelli, F, Martin, I, Martin, R, Martinez, V, Martynov, D, Masalehdan, H, Mason, K, Massera, E, Masserot, A, Massinger, T, Masso-Reid, M, Mastrogiovanni, S, Matas, A, Matichard, F, Matone, L, Mavalvala, N, Mccann, J, Mccarthy, R, Mcclelland, D, Mccormick, S, Mcculler, L, Mcguire, S, Mcisaac, C, Mciver, J, Mcmanus, D, Mcrae, T, Mcwilliams, S, Meacher, D, Meadors, G, Mehmet, M, Mehta, A, Meidam, J, Villa, E, Melatos, A, Mendell, G, Mercer, R, Mereni, L, Merfeld, K, Merilh, E, Merzougui, M, Meshkov, S, Messenger, C, Messick, C, Messina, F, Metzdorff, R, Meyers, P, Meylahn, F, Miani, A, Miao, H, Michel, C, Middleton, H, Milano, L, Miller, A, Millhouse, M, Mills, J, Milovich-Goff, M, Minazzoli, O, Minenkov, Y, Mishkin, A, Mishra, C, Mistry, T, Mitra, S, Mitrofanov, V, Mitselmakher, G, Mittleman, R, Mo, G, Moffa, D, Mogushi, K, Mohapatra, S, Molina-Ruiz, M, Mondin, M, Montani, M, Moore, C, Moraru, D, Morawski, F, Moreno, G, Morisaki, S, Mours, B, Mow-Lowry, C, Muciaccia, F, Mukherjee, A, Mukherjee, D, Mukherjee, S, Mukund, N, Mullavey, A, Munch, J, Muniz, E, Muratore, M, Murray, P, Nagar, A, Nardecchia, I, Naticchioni, L, Nayak, R, Neil, B, Neilson, J, Nelemans, G, Nelson, T, Nery, M, Neunzert, A, Nevin, L, Ng, K, Ng, S, Nguyen, C, Nguyen, P, Nichols, D, Nichols, S, Nissanke, S, Nocera, F, North, C, Nuttall, L, Obergaulinger, M, Oberling, J, O'Brien, B, Oganesyan, G, Ogin, G, Oh, J, Oh, S, Ohme, F, Ohta, H, Okada, M, Oliver, M, Oppermann, P, Oram, R, O'Reilly, B, Ormiston, R, Ortega, L, O'Shaughnessy, R, Ossokine, S, Ottaway, D, Overmier, H, Owen, B, Pace, A, Pagano, G, Page, M, Pagliaroli, G, Pai, A, Pai, S, Palamos, J, Palashov, O, Palomba, C, Pan, H, Panda, P, Pang, P, Pankow, C, Pannarale, F, Pant, B, Paoletti, F, Paoli, A, Parida, A, Parker, W, Pascucci, D, Pasqualetti, A, Passaquieti, R, Passuello, D, Patil, M, Patricelli, B, Payne, E, Pearlstone, B, Pechsiri, T, Pedersen, A, Pedraza, M, Pedurand, R, Pele, A, Penn, S, Perego, A, Perez, C, Perigois, C, Perreca, A, Petermann, J, Pfeiffer, H, Phelps, M, Phukon, K, Piccinni, O, Pichot, M, Piergiovanni, F, Pierro, V, Pillant, G, Pinard, L, Pinto, I, Pirello, M, Pitkin, M, Plastino, W, Poggiani, R, Pong, D, Ponrathnam, S, Popolizio, P, Porter, E, Powell, J, Prajapati, A, Prasad, J, Prasai, K, Prasanna, R, Pratten, G, Prestegard, T, Principe, M, Prodi, G, Prokhorov, L, Punturo, M, Puppo, P, Purrer, M, Qi, H, Quetschke, V, Quinonez, P, Raab, F, Raaijmakers, G, Radkins, H, Radulesco, N, Raffai, P, Raja, S, Rajan, C, Rajbhandari, B, Rakhmanov, M, Ramirez, K, Ramos-Buades, A, Rana, J, Rao, K, Rapagnani, P, Raymond, V, Razzano, M, Read, J, Regimbau, T, Rei, L, Reid, S, Reitze, D, Rettegno, P, Ricci, F, Richardson, C, Richardson, J, Ricker, P, Riemenschneider, G, Riles, K, Rizzo, M, Robertson, N, Robinet, F, Rocchi, A, Rolland, L, Rollins, J, Roma, V, Romanelli, M, Romano, J, Romano, R, Romel, C, Romie, J, Rose, C, Rose, D, Rose, K, Rosinska, D, Rosofsky, S, Ross, M, Rowan, S, Rudiger, A, Ruggi, P, Rutins, G, Ryan, K, Sachdev, S, Sadecki, T, Sakellariadou, M, Salafia, O, Salconi, L, Saleem, M, Samajdar, A, Sammut, L, Sanchez, E, Sanchez, L, Sanchis-Gual, N, Sanders, J, Santiago, K, Santos, E, Sarin, N, Sassolas, B, Sathyaprakash, B, Sauter, O, Savage, R, Schale, P, Scheel, M, Scheuer, J, Schmidt, P, Schnabel, R, Schofield, R, Schonbeck, A, Schreiber, E, Schulte, B, Schutz, B, Scott, J, Scott, S, Seidel, E, Sellers, D, Sengupta, A, Sennett, N, Sentenac, D, Sequino, V, Sergeev, A, Setyawati, Y, Shaddock, D, Shaffer, T, Shahriar, M, Shaner, M, Sharma, A, Sharma, P, Shawhan, P, Shen, H, Shink, R, Shoemaker, D, Shukla, K, Shyamsundar, S, Siellez, K, Sieniawska, M, Sigg, D, Singer, L, Singh, D, Singh, N, Singhal, A, Sintes, A, Sitmukhambetov, S, Skliris, V, Slagmolen, B, Slaven-Blair, T, Smith, J, Smith, R, Somala, S, Son, E, Soni, S, Sorazu, B, Sorrentino, F, Souradeep, T, Sowell, E, Spencer, A, Spera, M, Srivastava, A, Srivastava, V, Staats, K, Stachie, C, Standke, M, Steer, D, Steinke, M, Steinlechner, J, Steinlechner, S, Steinmeyer, D, Stevenson, S, Stocks, D, Stone, R, Stops, D, Strain, K, Stratta, G, Strigin, S, Strunk, A, Sturani, R, Stuver, A, Sudhir, V, Summerscales, T, Sun, L, Sunil, S, Sur, A, Suresh, J, Sutton, P, Swinkels, B, Szczepanczyk, M, Tacca, M, Tait, S, Talbot, C, Tanner, D, Tao, D, Tapai, M, Tapia, A, Tasson, J, Taylor, R, Tenorio, R, Terkowski, L, Thomas, M, Thomas, P, Thondapu, S, Thorne, K, Thrane, E, Tiwari, S, Tiwari, V, Toland, K, Tonelli, M, Tornasi, Z, Torres-Forne, A, Torrie, C, Toyr, D, Travasso, F, Traylor, G, Tringali, M, Tripathee, A, Trovato, A, Trozzo, L, Tsang, K, Tse, M, Tso, R, Tsukada, L, Tsuna, D, Tsutsui, T, Tuyenbayev, D, Ueno, K, Ugolini, D, Unnikrishnan, C, Urban, A, Usman, S, Vahlbruch, H, Vajente, G, Valdes, G, Valentini, M, Bakel, N, Beuzekom, M, Brand, J, Broeck, C, Vander-Hyde, D, Schaaf, L, Vanheijningen, J, Veggel, A, Vardaro, M, Varma, V, Vass, S, Vasuth, M, Vecchio, A, Vedovato, G, Veitch, J, Veitch, P, Venkateswara, K, Venugopalan, G, Verkindt, D, Vetrano, F, Vicere, A, Viets, A, Vinciguerra, S, Vine, D, Vinet, J, Vitale, S, Vo, T, Vocca, H, Vorvick, C, Vyatchanin, S, Wade, A, Wade, L, Wade, M, Walet, R, Walker, M, Wallace, L, Walsh, S, Wang, H, Wang, J, Wang, S, Wang, W, Wang, Y, Ward, R, Warden, Z, Warner, J, Was, M, Watchi, J, Weaver, B, Wei, L, Weinert, M, Weinstein, A, Weiss, R, Wellmann, F, Wen, L, Wessel, E, Wessels, P, Westhouse, J, Wette, K, Whelan, J, Whiting, B, Whittle, C, Wilken, D, Williams, D, Williamson, A, Willis, J, Willke, B, Winkler, W, Wipf, C, Wittel, H, Woan, G, Woehler, J, Wofford, J, Wright, J, Wu, D, Wysocki, D, Xiao, S, Xu, R, Yamamoto, H, Yancey, C, Yang, L, Yang, Y, Yang, Z, Yap, M, Yazback, M, Yeeles, D, Yu, H, Yuen, S, Zadrozny, A, Zanolin, M, Zelenova, T, Zendri, J, Zevin, M, Zhang, J, Zhang, L, Zhang, T, Zhao, C, Zhao, G, Zhou, M, Zhou, Z, Zhu, X, Zimmerman, A, Zucker, M, Zweizig, J, Laboratoire des matériaux avancés (LMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique 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Astrophysique Relativiste Théories Expériences Métrologie Instrumentation Signaux (ARTEMIS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut des Fonctions Optiques pour les Technologies de l'informatiON (Institut FOTON), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut 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Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Spectroscopies optiques des matériaux verres, amorphes et à nanoparticules (SOPRANO), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), LIGO Scientific Collaboration, Virgo Collaboration, Arène, M., Bécsy, B., Bustillo, J. Calderón, Diaz, J. Casanueva, Cavaglià, M., Cerdá-Durán, P., Cieślar, M., Cordero-Carrión, I., Dálya, G., D’Angelo, B., D’Antonio, S., Deléglise, S., Pozzo, W. Del, de Varona, O., Díaz, M. C., Vivanco, Francisco Hernandez, Fronzè, G., García-Quirós, C., Ghosh, Abhirup, Ghosh, Archisman, González, G., Gupta, Anchal, Hübner, M. T., Kéfélian, F., Kim, Chunglee, Krämer, C., Królak, A., Kumar, Rahul, Kumar, Rakesh, Lück, H., Hernandez, I. Magaña, Magaña-Sandoval, F., Márka, S., Márka, Z., Villa, E. Mejuto, Mukherjee, Arunava, Mukherjee, Subroto, Muñiz, E. A., O’Brien, B. D., Oram, Richard J., O’Reilly, B., O’Shaughnessy, R., Périgois, C., Pinto, I. M., Pürrer, M., Rana, Javed, Rosińska, D., Rüdiger, A., Schönbeck, A., Szczepańczyk, M. J., Tápai, M., Tiwari, Shubhanshu, Tiwari, Srishti, Torres-Forné, A., Töyrä, D., Bakel, N. van, Beuzekom, M. van, Brand, J. F. J. van den, Broeck, C. Van Den, Schaaf, L. van der, Veggel, A. A. van, Vasúth, M., Viceré, A., Weßels, P., Yu, Hang, Yu, Haocun, Zadrożny, A. K., Zadrożny, A., RS: FSE MSP, Grav. waves and fundamental physics, RS: FSE Grav. waves and fundamental physics, Faculty of Science, Gravitation and Astroparticle Physics Amsterdam, Other Research IHEF (IoP, FNWI), IoP (FNWI), and Astroparticle Physics (IHEF, IoP, FNWI)

Subjects
Gravitació, neutron star: binary, cosmological model, 010504 meteorology & atmospheric sciences, Astronomy, Gravitational Waves, Hubble constant, O2, LIGO, Virgo, detector: network, 01 natural sciences, Cosmology, General Relativity and Quantum Cosmology, LIGO, dark energy, 010303 astronomy & astrophysics, QC, Physics, Settore FIS/01, Hubble constant, Settore FIS/05, CATALOG, Physical Sciences, symbols, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Astrophysics - Cosmology and Nongalactic Astrophysics, Cosmology and Nongalactic Astrophysics (astro-ph.CO), DATA RELEASE, COSMOLOGICAL PARAMETERS, FOS: Physical sciences, O2, General Relativity and Quantum Cosmology (gr-qc), Astrophysics::Cosmology and Extragalactic Astrophysics, Astronomy & Astrophysics, LUMINOSITY FUNCTIONS, gravitational radiation: direct detection, Gravitational-wave astronomy, 1ST, Article, electromagnetic field: production, symbols.namesake, Binary black hole, 0103 physical sciences, DISTRIBUTIONS, K-CORRECTIONS, SDG 7 - Affordable and Clean Energy, Astrophysique, STFC, 0105 earth and related environmental sciences, Gravitational Waves, Science & Technology, Gravitational wave, Virgo, RCUK, Astronomy and Astrophysics, cosmology, gravitational waves, 310 Galaxies and Cosmology, Galaxy, EVOLUTION, Dewey Decimal Classification::500 | Naturwissenschaften::520 | Astronomie, Kartographie, gravitational radiation detector, VIRGO, black hole: binary, Space and Planetary Science, [SDU]Sciences of the Universe [physics], DENSITY, gravitational radiation: emission, Dark energy, Astronomia, ddc:520, galaxy, Gravitational wave astronomy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Hubble's law
Abstract

This paper presents the gravitational-wave measurement of the Hubble constant (H 0) using the detections from the first and second observing runs of the Advanced LIGO and Virgo detector network. The presence of the transient electromagnetic counterpart of the binary neutron star GW170817 led to the first standard-siren measurement of H 0. Here we additionally use binary black hole detections in conjunction with galaxy catalogs and report a joint measurement. Our updated measurement is H 0 = km s-1 Mpc-1 (68.3% of the highest density posterior interval with a flat-in-log prior) which is an improvement by a factor of 1.04 (about 4%) over the GW170817-only value of km s-1 Mpc-1. A significant additional contribution currently comes from GW170814, a loud and well-localized detection from a part of the sky thoroughly covered by the Dark Energy Survey. With numerous detections anticipated over the upcoming years, an exhaustive understanding of other systematic effects are also going to become increasingly important. These results establish the path to cosmology using gravitational-wave observations with and without transient electromagnetic counterparts., 0, info:eu-repo/semantics/published

Published
2021

39. Encoding and Storage of Information in Mechanical Metamaterials

Author

Zhiqiang Meng, Hujie Yan, Mingchao Liu, Wenkai Qin, Guy M. Genin, and Chang Qing Chen

Subjects
General Chemical Engineering, General Engineering, General Physics and Astronomy, Medicine (miscellaneous), General Materials Science, Biochemistry, Genetics and Molecular Biology (miscellaneous)
Published
2023

46. Limpact de la pandmie sur les jeunes

Author

Dsire Stocker, Jolanda Jggi, France Genin, and Lea Pucci-Meier

Subjects
Microbiology (medical), Immunology, Immunology and Allergy
Published
2023

47. A discrete shear lag model of the mechanics of hitchhiker plants, and its prospective application to tendon-to-bone repair

Author

Ethan D. Hoppe, Victor Birman, Iden Kurtaliaj, C. Matt Guilliams, Barbara G. Pickard, Stavros Thomopoulos, and Guy M. Genin

Subjects
General Mathematics, General Engineering, General Physics and Astronomy
Abstract

Tendon-to-bone repairs often fail when sutures pull through tendon, like a wire through cheese. Repair strength is maximized when loads are balanced equally among all sutures, relative to the pullout resistance of the tendon and the strength of the sutures. This problem of balancing loads across multiple, discrete attachment sites has been solved in nature by hitchhiker plants that proliferate by adhering relatively stiff fruit to relatively soft fur and fabrics through arrays of hooks. We, therefore, studied the fruits of such a plant, Harpagonella palmeri , and developed a discrete shear lag analysis of the force distributions in H. palmeri 's linear arrays of long, slender hooks of varied lengths and spacing. Results suggested that strategies were used by the plant to distribute loads, including variations in the spacing and stiffnesses of hooks that serve to equalize forces over attachment sites. When applying these models to suturing schemes for surgical reattachment of tendon to bone, results suggested that strategies exhibited by H. palmeri show promise for balancing forces over sutures, potentially doubling repair strength relative to what could be achieved with a uniform suture distribution. Results suggest a potential pathway for strengthening surgical repairs, and more broadly for optimizing fasteners for bi-material attachment.

Published
2023

48. In Vivo Porcine Model of Acute Iliocaval Deep Vein Thrombosis

Author

Sophia Roberts, Mohamed Zaghloul, Usama Ismail, Roger A. Rowe, Connor Engel, Rodrigo Meade, Santiago Elizondo-Benedetto, Guy M. Genin, and Mohamed A. Zayed

Abstract

Acute deep vein thrombosis (DVT) is a potentially life-threatening condition in which blood clots form in the venous system. Recently, a number of endovascular thrombectomy devices have been commercialized for the treatment of acute DVT. With variable efficacy and safety profiles, the current state-of-the-art has identified potential areas for further device innovation and opportunities for improvement. However, a major limitation in the testing, verification, and validation of new thrombectomy is a clinically representative large animal model of acute DVT. Unfortunately, existing approaches to creating DVT in porcine models are time consuming, technically challenging, and provide inconsistent results. We therefore developed a rapid and more reproducible protocol for induction of large-volume iliocaval DVTs in a living porcine host. This approach involves sequestering the iliocaval with standard balloon occlusion catheters, and a controlled and limited infusion of a 25% ethanol solution within the sequestered segment. We observed that this method was safe, technically straightforward, and reproducible in creating large-volume acute DVTs. We believe this model can be utilized in a standardized approach for the future testing of future endovascular venous thrombectomy devices.

Published
2023

50. AUTOMATION OF CONTROL OF ROOM DEEP OIL PUMP USINGTRACE MODE SCADA SYSTEMS

Author

Valeriy S. Genin, Lidia N. Vasileva, Nadezhda N. Ivanova, Elmira M. Artykaeva, and Tatiana V. Dmitrieva

Abstract

The issues of automation of technological processes are relevant for all industries. The article discusses the issues of automating the control of the operation of oil pumping units widely used in oil production using the TRACE MODE SCADA system from AdAstrA Research Group. To control the operation of a sucker rod pump of an oil pumping unit, the use of dynamometers is widespread in world practice. Technically, it is easier to carry out a more generalized control of the operation of an oil pumping unit using a wattmetergram, which displays the dependence of the active power consumed by the drive on time or the position of the polished rod. The results of power measurements are transmitted via communication channels to the computer of the SCADA system. Further, preliminary processing of the results of the control of the wattmeter diagram and the calculation of parameters characterizing the operation of the oil pumping unit are performed. At the stage of data preprocessing, noise filtering is performed using TRACE MODE tools that provide data exchange with MS Excel, MS Access, MS Visual Basic packages. The use of moving average, median filtering, and B-splines methods for this is considered. It is shown that cubic B-splines are an effective method of analytical description and graphical representation of experimental data, reducing the total mean square of the error. The use of splines in comparison with the polynomial approximation gives a slightly better approximation. The results of filtering and calculations by means of the SCADA system are displayed on the dispatcher’s monitor, archived, documented, etc. Thus, the related software products SCADA TRACE MODE and MS allow you to effectively implement complex data processing algorithms.

Published
2022

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