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2 results on '"Gauvreau, Kimberlee"'

1. Treatment Intensification in Patients With Kawasaki Disease and Coronary Aneurysm at Diagnosis

Author

Dionne, Audrey, Burns, Jane C, Dahdah, Nagib, Tremoulet, Adriana H, Gauvreau, Kimberlee, de Ferranti, Sarah D, Baker, Annette L, Son, Mary Beth, Gould, Patrick, Fournier, Anne, Newburger, Jane W, and Friedman, Kevin G

Subjects
Male, Adolescent, Clinical Trials and Supportive Activities, Immunoglobulins, Mucocutaneous Lymph Node Syndrome, Medical and Health Sciences, Pediatrics, Rare Diseases, Clinical Research, Risk Factors, hemic and lymphatic diseases, Humans, cardiovascular diseases, Child, Preschool, Retrospective Studies, Prevention, Psychology and Cognitive Sciences, Coronary Aneurysm, Infant, Infliximab, Treatment Outcome, 6.1 Pharmaceuticals, Antirheumatic Agents, Immunization, Female, Intravenous, Follow-Up Studies
Abstract

BackgroundCoronary artery aneurysms (CAA) are a serious complication of Kawasaki disease. Treatment with intravenous immunoglobulin (IVIg) within 10 days of fever onset reduces the risk of CAA from 25% to

Published
2019

2. Risk Model Development and Validation for Prediction of Coronary Artery Aneurysms in Kawasaki Disease in a North American Population

Author

Son, Mary Beth F, Gauvreau, Kimberlee, Tremoulet, Adriana H, Lo, Mindy, Baker, Annette L, de Ferranti, Sarah, Dedeoglu, Fatma, Sundel, Robert P, Friedman, Kevin G, Burns, Jane C, and Newburger, Jane W

Subjects
Male, Adolescent, coronary aneurysm, Mucocutaneous Lymph Node Syndrome, risk score, Cardiorespiratory Medicine and Haematology, Cardiovascular, Risk Assessment, California, Risk Factors, Predictive Value of Tests, Clinical Research, Humans, echocardiography, Prospective Studies, Child, Preschool, Heart Disease - Coronary Heart Disease, Retrospective Studies, Randomized Controlled Trials as Topic, Kawasaki disease, Prevention, Age Factors, Reproducibility of Results, Infant, C-Reactive Protein, Asian Americans, Heart Disease, Disease Progression, Female, Biomarkers, Boston
Abstract

Background Accurate prediction of coronary artery aneurysms ( CAAs ) in patients with Kawasaki disease remains challenging in North American cohorts. We sought to develop and validate a risk model for CAA prediction. Methods and Results A binary outcome of CAA was defined as left anterior descending or right coronary artery Z score ≥2.5 at 2 to 8weeks after fever onset in a development cohort (n=903) and a validation cohort (n=185) of patients with Kawasaki disease. Associations of baseline clinical, laboratory, and echocardiographic variables with later CAA were assessed in the development cohort using logistic regression. Discrimination (c statistic) and calibration (Hosmer-Lemeshow) of the final model were evaluated. A practical risk score assigning points to each variable in the final model was created based on model coefficients from the development cohort. Predictors of CAAs at 2 to 8weeks were baseline Z score of left anterior descending or right coronary artery ≥2.0, age 40-fold greater in the validation cohort (odds ratio, 44.0; 95% CI, 10.8-180 [ P

Published
2019

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