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An important aspect of business process modelling is let non-professional users understand business processes, so that they can be involved not only in their understanding but even in their management. This paper introduces a business process editor geared to end users whose prerequisites are very elementary. The editor has been developed by the DIS of University of Naples “Federico II”, in a partnership with the IBM Software Group Lab in Rome. The application has been developed on Eclipse Ganymede platform, and the first release is currently beeing tested at DIS. Cooperative design and development was made using IBM Rational Team Concert [1].

A review is given of the studies aimed at extending to the thermodynamic limit stability results of Nekhoroshev type for nearly integrable Hamiltonian systems. The physical relevance of such an extension, i. e., of proving the persistence of regular (or ordered) motions in that limit, is also discussed. This is made in connection both with the old Fermi–Pasta–Ulam problem, which gave origin to such discussions, and with the optical spectral lines, the existence of which was recently proven to be possible in classical models, just in virtue of such a persistence.

// Adriana Amaro 1, * , Giovanna Angelini 1, * , Valentina Mirisola 1 , Alessia Isabella Esposito 1 , Daniele Reverberi 1 , Serena Matis 1 , Massimo Maffei 1 , Walter Giaretti 1 , Maurizio Viale 2 , Rosaria Gangemi 2 , Laura Emionite 3 , Simonetta Astigiano 4 , Michele Cilli 3 , Beatrice E. Bachmeier 5 , Peter H. Killian 5 , Adriana Albini 6 , Ulrich Pfeffer 1 1 Molecular Pathology, IRCCS AOU San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy 2 Biotherapy, IRCCS AOU San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy 3 Animal Facility, IRCCS AOU San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy 4 Immunology, IRCCS AOU San Martino – IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy 5 Institute of Laboratory Medicine, Ludwig-Maximilians-University, Munich, Germany 6 Scientific and Technology Park, IRCCS MultiMedica, Milan, Italy * These authors have contributed equally to the work Correspondence to: Adriana Albini, email: adriana.albini@multimedica.it Ulrich Pfeffer, email: patologia.molecolare.integrata@gmail.com Keywords: breast cancer, invasion, apocrine breast cancer, metastasis, aneuploidy Received: May 16, 2016 Accepted: August 13, 2016 Published: September 10, 2016 ABSTRACT The acquisition of an invasive phenotype is a prerequisite for metastasization, yet it is not clear whether or to which extent the invasive phenotype is linked to other features characteristic of metastatic cells. We selected an invasive subpopulation from the triple negative breast cancer cell line MDA-MB-231, performing repeated cycles of preparative assays of invasion through Matrigel covered membranes. The invasive sub-population of MDA-MB-231 cells exhibits stronger migratory capacity as compared to parental cells confirming the highly invasive potential of the selected cell line. Prolonged cultivation of these cells did not abolish the invasive phenotype. ArrayCGH, DNA index quantification and karyotype analyses confirmed a common genetic origin of the parental and invasive subpopulations and revealed discrete structural differences of the invasive subpopulation including increased ploidy and the absence of a characteristic amplification of chromosome 5p14.1-15.33. Gene expression analyses showed a drastically altered expression profile including features of apocrine breast cancers and of invasion related matrix-metalloproteases and cytokines. The invasive cells showed accelerated proliferation, increased apoptosis, and an altered pattern of chemo-sensitivity with lower IC50 values for drugs affecting the mitotic apparatus. However, the invasive cell population is significantly less tumorigenic in orthotopic mouse xenografts suggesting that the acquisition of the invasive capacity and the achievement of metastatic growth potential are distinct events.

The theoretical dispersion curves n(ω) (refractive index vs. frequency) of ionic crystals in the infrared domain are expressed, within the Green-Kubo theory, in terms of a time correlation function involving the motion of the ions only. The aim of this paper is to investigate how well the experimental data are reproduced by a classical approximation of the theory, in which the time correlation functions are expressed in terms of the ions orbits. We report the results of molecular-dynamics (MD) simulations for the ions motions of a LiF lattice of 4096 ions at room temperature. The theoretical curves thus obtained are in surprisingly good agreement with the experimental data, essentially over the whole infrared domain. This shows that at room temperature the motion of the ions develops essentially in a classical regime.