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1. Strumenti e indicazioni di governance transfrontaliera. Piano d’azione e linee guida del progetto IMPACT [Instruments et indications pour la gouvernance transfrontalière. Plan d’action et lignes directrices du projet IMPACT]

Author

Magaldi, M. G., Barbieri, L., Mantovani, C., Baratti, M., Bendoni, M., Berta, M., Berto, D., Bigongiari, N., Boccacci, A., Bramanti, L., Brandini, C., Calace, N., Caliani, I., Cannicci, S., Casini, S., Connès, C., Corgnati, L. P., Costanza, L., Coudray, S., Cristofori, S., Di Mento, R., Doronzo, B., Dumas, D., Fattorini, M., Femiano, R., Fratini, S., Galgani, F., Galli, T., Gozzini, B., Gramoullé, A., Grassini, I., Griffa, A., Guizien, K., Guérin, C. A., Iozzelli, M., Lapucci, C., Lenoble, V., Maltese, S., Mario, S., Mazoyer, C., Mengoni, A., Menonna, V., Molcard, A., Oliva, M., Ortolani, A., Ourmières, Y., Padrón, M., Piermarini, R., Pretti, C., Romanelli, G., Ruberti, G., Scarpato, A., Sciascia, R., Silvestri, C., Taddei, S., Ugolini, A., Vanneste, H., Vannucchi, V., and Xu, D.

Published
2021

3. Evidence of a new narrow state in anti-n p annihilation in flight

Author

Balestra, F., Bonazzola, G. C., Botta, E., Bressani, T., Bussa, M. P., Busso, L., Calvo, D., Cerello, P., Costa, S., D Isep, F., Fava, L., Feliciello, A., Ferrero, L., Filippi, A., Garfagnini, R., Grasso, A., Maggiora, A., Marcello, S., Panzieri, D., Piragino, G., Rossetto, E., Tosello, F., Zosi, G., Agnello, M., Iazzi, F., Minetti, B., Bertin, A., Bruschi, M., Capponi, M., Cereda, B., Castro, S., Galli, T. D., Giacobbe, B., Marconi, U., Massa, I., Piccinini, M., Semprini-Cesari, N., Spighi, R., Vecchi, S., Villa, M., Vitale, A., Zoccoli, A., Belli, G., Corradini, M., Donzella, A., Lodi Rizzini, E., Venturelli, L., Zenoni, A., Bendiscioli, G., Filippini, V., Fontana, A., Montagna, P., Rotondi, A., Saino, A., Salvini, P., Tretyak, V. I., Adamo, A., Cicalo, C., Masoni, A., Puddu, G., Serci, S., Temnikov, P., Gianluca Usai, Ableev, V., Denisov, D. Yu, Prakhov, S. N., Rozhdestvensky, A. M., Sapozhnikov, M. G., Poli, M., Leo, C., Gianotti, P., Guaraldo, C., Lanaro, A., Lucherini, V., Nichitiu, F., Boccaccio, P., Gastaldi, U., Lombardi, M., Maron, G., Ricci, R. A., Vannucci, L., Vedovato, G., Morando, M., Margagliotti, G. V., Pauli, G., Tessaro, S., and Santi, L.

5. TI-VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes

Author

Alessio Colombo, Maura Francolini, Thierry Galli, Loredana Riganti, Michela Matteoli, Claire Wilhelm, Matteo Bergami, Cinzia Cagnoli, Ursula Schenk, Marco Canossa, Emanuela Zuccaro, Carolina Frassoni, Lydia Danglot, Claudia Verderio, Verderio C, Cagnoli C, Bergami M, Francolini M, Schenk U, Colombo A, Riganti L, Frassoni C, Zuccaro E, Danglot L, Wilhelm C, Galli T, Canossa M, Matteoli M., Department of Medical Pharmacology and Consiglio Nazionale delle Ricerche - Istitute of Neuroscience, University of Milano, Consiglio Nazionale delle Ricerche [Roma] (CNR), Fondazione Filarete, Dpt of Neuroscience and Brain Technologies [Genova], NeuroEngineering & bio-arTificial Synergic SystemS Laboratory [Genova] (NetS3 Lab), Istituto Italiano di Tecnologia (IIT)-Istituto Italiano di Tecnologia (IIT), Epileptology and Experimental Neurophysiology Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Matière et Systèmes Complexes (MSC (UMR_7057)), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Don C. Gnocchi, Istituto Di Ricovero e Cura a Carattere Scientifico Fondazione Fon C. Gnocchi, and Cariplo 2008-3104, FISM 2010/R/39, Progetto CIPE/Limonte, INSERM (Avenir Program), European Commission 'Signalling and Traffic' [STREP 503229], Association pour la Recherche sur le Cancer, Agence Nationale pour la Recherche 'Astrex', Mairie de Paris Medical Research and Health Program, Fondation pour la Recherche Médicale, Association pour la Recherche sur le Cancer, Agence Nationale pour la Recherche

Subjects
Primary Cell Culture, chemistry.chemical_element, TI-VAMP/VAMP7, Down-Regulation, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Calcium, Transfection, Hippocampus, Membrane Fusion, Cathepsin B, Exocytosis, R-SNARE Proteins, 03 medical and health sciences, 0302 clinical medicine, Adenosine Triphosphate, Secretory lysosomes, Downregulation and upregulation, Lysosome, medicine, Animals, Humans, Secretion, RNA, Small Interfering, 030304 developmental biology, Cerebral Cortex, 0303 health sciences, Vesicle, Cell Biology, General Medicine, Glioma, Secretory lysosome, Embryo, Mammalian, Cell biology, Rats, ATP, medicine.anatomical_structure, Membrane protein, chemistry, Astrocytes, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Lysosomes, Neuroglia, 030217 neurology & neurosurgery, Protein Binding, Signal Transduction
Abstract

International audience; BACKGROUND INFORMATION: ATP is the main transmitter stored and released from astrocytes under physiological and pathological conditions. Morphological and functional evidence suggest that besides secretory granules, secretory lysosomes release ATP. However, the molecular mechanisms involved in astrocytic lysosome fusion remain still unknown. RESULTS: In the present study, we identify tetanus neurotoxin-insensitive vesicle-associated membrane protein (TI-VAMP, also called VAMP7) as the vesicular SNARE which mediates secretory lysosome exocytosis, contributing to release of both ATP and cathepsin B from glial cells. We also demonstrate that fusion of secretory lysosomes is triggered by slow and locally restricted calcium elevations, distinct from calcium spikes which induce the fusion of glutamate-containing clear vesicles. Downregulation of TI-VAMP/VAMP7 expression inhibited the fusion of ATP-storing vesicles and ATP-mediated calcium wave propagation. TI-VAMP/VAMP7 downregulation also significantly reduced secretion of cathepsin B from glioma. CONCLUSIONS: Given that sustained ATP release from glia upon injury greatly contributes to secondary brain damage and cathepsin B plays a critical role in glioma dissemination, TI-VAMP silencing can represent a novel strategy to control lysosome fusion in pathological conditions.

Published
2011

6. A common exocytotic mechanism mediates axonal and dendritic outgrowth

Author

Thierry Galli, Mauro Mezzina, Philipp Alberts, Michela Matteoli, Pascale Bouillé, Ursula Schenk, Daniel Louvard, Gaëll Mainguy, Sonia Martinez-Arca, Alain Prochiantz, Silvia Coco, Martinez Arca, S, Coco, S, Mainguy, G, Schenk, U, Alberts, P, Bouillé, P, Mezzina, M, Prochiantz, A, Matteoli, M, Louvard, D, and Galli, T

Subjects
Gene Expression, Dendrite, Hippocampal formation, Autoantigens, R-SNARE Proteins, Mice, Calcium-binding protein, Protein Isoforms, Axon, Membrane Protein, Cells, Cultured, Calcium-Binding Protein, Neurons, Endocytosi, Qa-SNARE Proteins, General Neuroscience, Luminescent Protein, Brain, Transfection, Endocytosis, Cell biology, Electroporation, medicine.anatomical_structure, Ribonucleoproteins, Neurite, Recombinant Fusion Proteins, Green Fluorescent Proteins, In Vitro Techniques, Biology, Green Fluorescent Protein, Exocytosis, Exocytosi, Autoantigen, R-SNARE Protein, medicine, Animals, ARTICLE, Qa-SNARE Protein, Animal, In Vitro Technique, Calcium-Binding Proteins, Membrane Proteins, Protein Isoform, Dendrites, Ribonucleoprotein, Neuron, Axons, Rats, Protein Structure, Tertiary, Luminescent Proteins, nervous system, Membrane protein, Rat, Calreticulin, Recombinant Fusion Protein
Abstract

Outgrowth of the dendrites and the axon is the basis of the establishment of the neuronal shape, and it requires addition of new membrane to both growing processes. It is not yet clear whether one or two exocytotic pathways are responsible for the respective outgrowth of axons and dendrites. We have previously shown that tetanus neurotoxin-insensitive vesicle-associated membrane protein (TI-VAMP) defines a novel network of tubulovesicular structures present both at the leading edge of elongating dendrites and axons of immature hippocampal neurons developing in primary culture and that TI-VAMP is an essential protein for neurite outgrowth in PC12 cells. Here we show that the expression of the N-terminal domain of TI-VAMP inhibits the outgrowth of both dendrites and axons in neurons in primary culture. This effect is more prominent at the earliest stages of the development of neuronsin vitro. Expression of the N-terminal domain deleted form of TI-VAMP has the opposite effect. This constitutively active form of TI-VAMP localizes as the endogenous protein, particularly concentrating at the leading edge of growing axons. Our results suggest that a common exocytotic mechanism that relies on TI-VAMP mediates both axonal and dendritic outgrowth in developing neurons.

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